Ana Sofia Marques Travassos, Isaura Regadas, Mário Alfaiate, Eduardo Silva, Rui Proença, António Travassos,
Travassos, Ana S. MD; Regadas, Isaura MD; Alfaiate, Mário MD; Silva, Eduardo D. PhD; Proença, Rui PhD; Travassos, António MDEditor(s): Williams, George A. Author Information
Tópico(s): Intraocular Surgery and Lenses
2013 - Lippincott Williams & Wilkins | Retina
Antonin Bal, Mary‐Anne Trabaud, Jean‐Baptiste Fassier, Muriel Rabilloud, Kahina Saker, Carole Langlois‐Jacques, Nicolas Guibert, Adèle Paul, Dulce Alfaiate, Amélie Massardier-Pilonchéry, Virginie Pitiot, Florence Morfin‐Sherpa, Bruno Lina, Bruno Pozzetto, Sophie Trouillet-Assant, Jérôme Adnot, Alfaiate Dulce, Bal Antonin, BODERING Alain, Boibieux André, Bonnet Florent, Bourgeois Gaëlle, Brunel-Dalmas Florence, Caire Eurydice, Charbotel Barbara, Chiarello Pierre, Cotte Laurent, Constance d’Aubarede, Durupt François, Escuret Vanessa, Fascia Pascal, Fassier Jean-Baptiste, Fontaine Juliette, Gaillot-Durand Lucie, Gaymard Alexandre, Gillet Myriam, Godinot Matthieu, G François, Nicolas Guibert, Josset Laurence, Matthieu Lahousse, Lina Bruno, Lozano Hélène, Makhloufi Djamila, Massardier-Pilonchéry Amélie, Milon Marie-Paule, Moll Frédéric, Morfin Florence, N. Gnanamalar David, Nazare Julie-Anne, Oria Fatima, Paul Adèle, Perry Marielle, Pitiot Virginie, Prudent Mélanie, Muriel Rabilloud, Samperiz Audrey, Schlienger Isabelle, Chantal Simon, Trabaud Mary-Anne, Trouillet-Assant Sophie, V. Martine,
Tópico(s): COVID-19 epidemiological studies
2021 - Elsevier BV | Clinical Microbiology and Infection
Julie Lucifora, Dulce Alfaiate, Caroline Pons, Maud Michelet, Ricardo Ramírez, Floriane Fusil, Fouzia Amirache, Axel Rossi, Anne-Flore Legrand, Émilie Charles, Serena Vegna, Rayan Farhat, Michel Rivoire, Guillaume Passot, Nicolas Gadot, Barbara Testoni, C Bach, Thomas F. Baumert, Anastasia Hyrina, Rudolf K. Beran, Fabien Zoulim, André Boonstra, Hildegard Büning, Éloi R. Verrier, François-Loı̈c Cosset, Simon P. Fletcher, Anna Salvetti, David Durantel,
Background & Aims Chronic co-infection with hepatitis B and D viruses (HBV and HDV) leads to the most aggressive form of chronic viral hepatitis. Here, we aimed at elucidating the molecular mechanisms leading to the interference of HDV on HBV observed in most co-infected patients. Methods Patient liver tissues, primary human hepatocytes, HepaRG cells and human liver chimeric mice were used to analyze the effect of HDV on HBV using virological and RNA-seq analyses, as well as RNA synthesis, stability ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2023 - Elsevier BV | Journal of Hepatology
Hongchao Pan, Richárd Pető, Ana María Henao-Restrepo, Marie‐Pierre Préziosi, Vasee Moorthy, Quarraisha Abdool Karim, Marissa Alejandria, Patricia García, Marie-Paule Kiény, Reza Malekzadeh, Srinivas Murthy, K. Srinath Reddy, Mirta Roses Periago, Pierre Abi Hanna, Akaki Abutidze, Florence Ader, Abdullah Al-Bader, Almonther Alhasawi, Emma Allum, Adhra Al‐Mawali, Athari Alotaibi, Carlos Álvarez, Sheila Appadoo, Derk L. Arts, Abdullah M. Asiri, Pål Aukrust, Andreas Barratt‐Due, Abebe Genetu Bayih, H. Beaumont, Samir Bellani, Virginia Benassi, Balram Bhargava, Mattia Branca, Heike Cappel-Porter, Nery Cerrato, Fadima Cheick Haidara, Ting Soo Chow, Nadia Como, Joe Eustace, Tamar Gabunia, Patricia García, Sheela Godbole, Eduardo Gotuzzo, Laimonas Griškevičius, Rasha Hamra, Mariam Hassan, Mohamed Hassany, David W. Hutton, Irmansyah Irmansyah, Ligita Jančorienė, Faryal Khamis, Jana Kirwan, Suresh Kumar, Peter Lennon, Gustavo Lopardo, Patrick Lydon, Nicola Magrini, Suzana Manevska, Oriol Manuel, Sybil McGinty, Marco T. Medina, Maria Lucia Mesa Rubio, María Consuelo Miranda, Jeremy Nel, Estêvão Portela Nunes, Markus Perola, Antonio Portolés, Menaldi Rasmin, Aun Raza, Helen Rees, Paula Reges, Chris Rogers, Kolawole Salami, Marina I. Salvadori, Mamatha Sauermann, Narvina Sinani, Samba O. Sow, Jonathan A C Sterne, Milena Stevanoviкј, Evelina Tacconelli, Fernando Maltêz, Mekonnen Teferi, Kari A.O. Tikkinen, Sven Trelle, Tengiz Tsertsvadze, Hala Zaid, John-Arne Røttingen, Soumya Swaminathan, Michael P. Ryan, Nevila Gjermeni, Esmeralda Meta, Damian Águila, Ignacio Alonso, Marcos Altamirano, María López Álvarez, Rodrigo Alzola, Verónica Arce, Patricia Arribillaga, Rafael Ávila, Juan Pablo Balbuena, Laura Barcelona, José Barletta, María Benedetti, Verónica Berdiñas, Julieta Burgui, Sabrina Caimi, Juan Carrillo, Juan Carrizo, Juan Castelli, Alexis Cazaux, Flavia Cervellino, Angelo Chalco, Viviana Chediack, Eleonora Cunto, N. D'Amico, Lautaro De Vedia, Carolina Delgado, Debora Di Pilla, Miguel Ángel Díaz, Pablo Díaz Aguiar, Cecilia Domínguez, Leonor Ellero, Javier Farina, José Rodrigo Espinosa Fernández, Roxana Ferreyra, Maria Maddalena Filippi, Carolina Fogar, Pablo S. Frare, Celeste Giudiche, Mariana L. Golikow, María Georgina Gomez, Laura Hermida, Mariano Hurtado, Mariela Jacobo, Martin Jaume, Diego Laplume, María Lescano, Nicolás Lista, Flavia Loiacono, Ana Belen López, Marcelo Losso, Cecilia Luna, Sergio Lupo, Leonardo Marianelli, Anabella Martin, Florencia M. Masciottra, Analía Mykietiuk, L. Orellano, Valeria Pachioli, María José Padilla, Cecilia Pallavicini, Jazmin Patroso, Luz Perez Blanco, José Presas, Matias Provenzano, Lorena Lavera, Viviana Reichert, F José Luis Riveros, Alejandra Rodríguez, María José Rolón, Carolina Salvay, María Simonetta, Alicia Sisto, Sandra Themines, Fernando Tito, Javier Toibaro, Graciela Torales, Luciano Verón, Carla Vizzotti, Alexander Egle, Richard Greil, Michael Joannidis, Antoine Altdorfer, Leïla Belkhir, Vincent Fraipont, Maya Hites, Érico Arruda, Giovanni Luís Breda, Arthur Colussi, Miran Corradi, Júlio Croda, Helena Duani, Esaú João, Elizabeth S. Machado, Fernanda Carvalho de Queiroz Mello, Demócrito Miranda Filho, Poliana Monteiro, Ceuci Nunes, Luiz Carlos Pereira, Gustavo Pinto, Sônia Mara Raboni, M. Á. Barón Ramos, Leonardo Ruffing, Valdilea Santos, Tamara Souza, Melissa Soares Medeiros, Alexandre Vargas Schwarzbold, Karim Ali, Tanweer Azher, David Bellemare, Alexandra Binnie, Sergio Borgia, Yiorgos Alexandros Cavayas, Nicholas Chagnon, Matthew P. Cheng, Eve Cloutier, John Conly, Cecilia T. Costiniuk, Nick Daneman, James Douglas, Catarina Downey, Erick Duan, Medeline Durand, Shane English, George Farjou, Evadiki Fera, Patricia Fontela, Rob Fowler, Mike Fralick, David Gregory Gamble, Anna Geagea, Jennifer Grant, Luke B. Harrison, Thomas Havey, Holly Hoang, Lauren E. Kelly, Yoav Keynan, Kosar Khwaja, Marina B. Klein, Christophe Kolan, Nadine Kronfli, François Lamontagne, Nelson Lee, Todd A. Lee, Rachel Lim, Alexandra Lostun, Erika MacIntyre, Isabelle Malhamé, Francois Martin-Carrier, Marlee McGuinty, Matthew Munan, Conar O’Neil, Daniel Ovakim, Jesse Papenburg, Ken Kuljit S. Parhar, Seema Nair Parvathy, Santiago Pérez-Patrigeón, Asgar Rishu, Moira Rushton, Kim Scherr, Kevin L. Schwartz, Makeda Semret, M Silverman, Ameeta E. Singh, Wendy Sligl, Stephanie Smith, Ranjani Somayaji, Darrell H. S. Tan, Tuong-Vi Tran, Alain Tremblay, Jennifer Tsang, Alexis F. Turgeon, Erik Vakil, Jason Weatherald, Cédric P. Yansouni, Ryan Zarychanski, Claudia Aristizabal, Juan Carlos Bravo, Monica Caicedo‐Roa, J. Mateos Chacon, Diego Garzón, Freddy Guevara, Silvia Lozano-Gonzàlez, Hugo Macareno, Anita Montañez-Ayala, José Oñate, Jose Rojas-Gambasica, Fernando Rosso, Carlos Saavedra, Sandra Valderrama, Eliana Vàquiro-Herrera, Fabio Varón-Vega, I.C. Guzmán Zuluaga, Amin Abdel Baki, Akram Abdelbary, Wael Abdel‐Razek, Wagdi Amin, Noha Asem, Gehan Elassal, Marwa Elshesheny, Mohamed Fathy, Naglaa Fathy, Notaila Fayed, Ahmed Hammam, Sahar M. Hassany, Hamdy Ibrahim,
BackgroundThe Solidarity trial among COVID-19 inpatients has previously reported interim mortality analyses for four repurposed antiviral drugs. Lopinavir, hydroxychloroquine, and interferon (IFN)-β1a were discontinued for futility but randomisation to remdesivir continued. Here, we report the final results of Solidarity and meta-analyses of mortality in all relevant trials to date.MethodsSolidarity enrolled consenting adults (aged ≥18 years) recently hospitalised with, in the view of their doctor, ...
Elsevier BV
Kahina Saker, Bruno Pozzetto, Vanessa Escuret, Virginie Pitiot, Amélie Massardier-Pilonchéry, Bouchra Mokdad, Carole Langlois‐Jacques, Muriel Rabilloud, Dulce Alfaiate, Nicolas Guibert, Jean‐Baptiste Fassier, Antonin Bal, Sophie Trouillet‐Assant, Mary‐Anne Trabaud,
The virus neutralization test (VNT) is the reference for the assessment of the functional ability of neutralizing antibodies (NAb) to block SARS-CoV-2 entry into cells. New competitive immunoassays measuring antibodies preventing interaction between the spike protein and its cellular receptor are proposed as surrogate VNT (sVNT). We tested three commercial sVNT (a qualitative immunochromatographic test and two quantitative immunoassays named YHLO and TECO) together with a conventional anti-spike IgG ...
Tópico(s): COVID-19 Clinical Research Studies
2022 - Elsevier BV | Journal of Clinical Virology
Yanis Merad, Alexandre Gaymard, Laurent Cotte, Thomas Perpoint, Dulce Alfaiate, Matthieu Godinot, Agathe Becker, O Cannesson, Anne-Sophie Batalla, Fatima Oria-Yassir, Sophie Landré, Florence Morfin, Maude Bouscambert, Florent Valour, Florence Ader, Anne Conrad,
Modified vaccinia virus Ankara vaccine (MVA-BN; Bavarian Nordic) is recommended to contacts of mpox cases up to 14 days post-exposure but the effectiveness of this strategy is unknown. Among 108 adults (≥ 18 years old) who received one dose of MVA-BN after exposure to mpox, 11 (10%) cases of breakthrough mpox were observed. Sexual exposure was associated with the risk of breakthrough mpox (p = 0.0179). Samples taken from vaccinated breakthrough mpox cases had similar rates of infectious virus isolation ...
Tópico(s): Rabies epidemiology and control
2022 - European Centre for Disease Prevention and Control | Eurosurveillance
Florence Ader, Nathan Peiffer‐Smadja, Julien Poissy, Maude Bouscambert‐Duchamp, Drifa Belhadi, Alpha Diallo, Christelle Delmas, Juliette Saillard, Aline Dechanet, Noémie Mercier, Axelle Dupont, Toni Alfaiate, François-Xavier Lescure, F. Raffi, François Goehringer, Antoine Kimmoun, Stéphane Jauréguiberry, Jean Reignier, Saad Nseir, François Danion, Raphaël Clère-Jehl, Kévin Bouiller, Jean-Christophe Navellou, V. Tolsma, André Cabié, Clément Dubost, Johan Courjon, Sylvie Leroy, Joy Mootien, Rostane Gaci, Bruno Mourvillier, Emmanuel Faure, Valérie Pourcher, Sébastien Gallien, Odile Launay, Karine Lacombe, Jean‐Philippe Lanoix, Alain Makinson, Guillaume Martin‐Blondel, Lila Bouadma, Élisabeth Botelho-Nevers, Amandine Gagneux‐Brunon, Olivier Épaulard, Lionel Piroth, Florent Wallet, Jean‐Christophe Richard, Jean Reuter, Thérèse Staub, Bruno Lina, Marion Noret, Claire Andréjak, Minh Patrick Lê, Gilles Peytavin, Maya Hites, Dominique Costagliola, Yazdan Yazdanpanah, Charles Burdet, France Mentré,
Abstract Objectives We evaluated the clinical, virological and safety outcomes of lopinavir/ritonavir, lopinavir/ritonavir–interferon (IFN)-β-1a, hydroxychloroquine or remdesivir in comparison to standard of care (control) in coronavirus 2019 disease (COVID-19) inpatients requiring oxygen and/or ventilatory support. Methods We conducted a phase III multicentre, open-label, randomized 1:1:1:1:1, adaptive, controlled trial (DisCoVeRy), an add-on to the Solidarity trial (NCT04315948, EudraCT2020-000936-23). The ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Elsevier BV | Clinical Microbiology and Infection
Antonin Bal, Karen Brengel–Pesce, Alexandre Gaymard, Grégory Quéromès, Nicolas Guibert, Émilie Frobert, Maude Bouscambert, Mary‐Anne Trabaud, Florence Allantaz-Frager, Guy Oriol, Valérie Cheynet, Constance d’Aubarede, Amélie Massardier-Pilonchéry, Marlyse Buisson, Julien Lupo, Bruno Pozzetto, Pascal Poignard, Bruno Lina, Jean‐Baptiste Fassier, Florence Morfin, Sophie Trouillet‐Assant, Jerôme Adnot, Dulce Alfaiate, Alain Bergeret, André Boibieux, Florent Bonnet, Florence Brunel-Dalmas, Eurydice Caire, Barbara Charbotel, Pierre Chiarello, Laurent Cotte, Constance d’Aubarede, François Durupt, Vanessa Escuret, Pascal Fascia, Juliette Fontaine, Lucie Gaillot-Durand, Myriam Gillet, Matthieu Godinot, François Gueyffier, Laurence Josset, Matthieu Lahousse, Hélène Lozano, Djamila Makhloufi, Marie-Paule Milon, Frédéric Moll, D. Narbey, Julie‐Anne Nazare, Fatima Oria, Marielle Perry, Virginie Pitiot, Mélanie Prudent, Muriel Rabilloud, Audrey Samperiz, Isabelle Schlienger, Chantal Simon, Martine Valette,
A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Nature Portfolio | Scientific Reports
Vincent Soriano, Carmen de Mendoza, Pablo Barreiro, Ana Treviño, Octavio Corral,
... 5), 830 (2021).Crossref, Medline, CAS, Google Scholar12. Alfaiate D, Clément S, Gomes D, Goossens N, Negro ...
Tópico(s): Hepatitis C virus research
2021 - Future Medicine | Future Microbiology
Dulce Alfaiate, Sophie Clément, Diana Gomes, Nicolas Goossens, Francesco Negro,
•HDV infection is associated with an increased risk of HCC in HBV-infected patients. •The association is stronger in high quality and/or prospective cohort studies. •The association between HDV and HCC is stronger in the setting of HIV coinfection. Background & Aims Chronic hepatitis D (CHD) is the most severe form of chronic viral hepatitis but its role in the development of hepatocellular carcinoma (HCC) remains debated. We conducted a systematic review and meta-analysis of epidemiological studies to ...
Tópico(s): Hepatitis C virus research
2020 - Elsevier BV | Journal of Hepatology
Bruno Grollemund, C. Dissaux, P Gavelle, Carla Pérez Martínez, Jimmy Mullaert, Toni Alfaiate, Antoine Guédeney,
The objective of this prospective, multidisciplinary and multicenter study was to explore the effect of a cleft lip, associated or not with a cleft palate, on parents, on parent-infant relationship, and on the baby's relational development. It also highlighted how the type of cleft and the timing of the surgery could impact this effect.158 infants, with Cleft lip with or without Palate, and their parents participated in this multicenter prospective cohort. Clinical evaluations were performed at ...
Tópico(s): Breastfeeding Practices and Influences
2020 - BioMed Central | BMC Pediatrics
Natali Abeywickrama Samarakoon, Jc Cortay, Camille Sureau, Susanne Müller, Dulce Alfaiate, Francesca Guerrieri, A. Chaikuad, Martin Schröder, Philippe Merle, Massimo Levrero, Paul Dény,
Abstract Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single-stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected cells by cellular RNA polymerases with the assistance of the small hepatitis delta antigen (S-HDAg). Here we show that S-HDAg binds the bromodomain (BRD) adjacent to zinc finger domain 2B (BAZ2B) protein, a regulatory subunit of BAZ2B-associated remodeling factor (BRF) ISWI chromatin remodeling complexes. shRNA-mediated silencing of BAZ2B ...
Tópico(s): interferon and immune responses
2020 - Nature Portfolio | Nature Communications
... performed another systematic review and meta-analysis.[19]Alfaiate D. Clément S. Gomes D. Goossens N. Negro ...
Tópico(s): Hepatitis C virus research
2020 - Elsevier BV | Journal of Hepatology
Nathalie Mentha, Sophie Clément, Francesco Negro, Dulce Alfaiate,
Hepatitis delta virus (HDV) is a defective virus that requires the hepatitis B virus (HBV) to complete its life cycle in human hepatocytes. HDV virions contain an envelope incorporating HBV surface antigen protein and a ribonucleoprotein containing the viral circular single-stranded RNA genome associated with both forms of hepatitis delta antigen, the only viral encoded protein. Replication is mediated by the host cell DNA-dependent RNA polymerases. HDV infects up to72 million people worldwide and ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2019 - Elsevier BV | Journal of Advanced Research
Marco Frederico Marques, Sónia Rodrigues, Miguel Raimundo, José Costa, João Pedro Marques, Mário Alfaiate, João Figueira,
To describe the prevalence of lamellar hole-associated epiretinal proliferation (LHEP) and to correlate this finding with lamellar macular hole (LMH) morphology and prognosis after a surgical or conservative approach.This is a retrospective multicenter case series comprising consecutive LMH patients followed for ≥6 months. Serial spectral-domain optical coherence tomographies were evaluated for the presence of epiretinal membrane (ERM) and LHEP, diameter of the LMH aperture, base, and floor thickness. ...
Tópico(s): Glaucoma and retinal disorders
2018 - Karger Publishers | Ophthalmologica
Joana Pereira, Arminda Neves, Pedro Alfaiate, Mônica de Oliveira Santos, Henrique Aragão, João Paulo Castro Sousa,
Purpose: Comparison of biometric measurements and calculation of intraocular lens with a new biometer (Pentacam®-AXL, Oculus, Germany) and a reference biometer (Lenstar LS 900®, Haag-Streit AG, Switzerland), in order to assess the agreement between these two devices. Setting: Centro Hospitalar de Leiria, Portugal Materials and methods: Prospective, institutional study, in which measurements of axial length, anterior chamber depth from the corneal epithelium and endothelium to the anterior surface ...
Tópico(s): Intraocular Surgery and Lenses
2018 - SAGE Publishing | European Journal of Ophthalmology
Fabien Hyafil, Renata Chequer, Emmanuel Sorbets, Candice Estellat, Grégory Ducrocq, François Rouzet, Toni Alfaiate, Hamza Regaieg, Jérémie Abtan, S. Leygnac, Milan Milliner, Laëtitia Imbert, Samuel Burg, Rana Ben Azzouna, Louis Potier, Cédric Laouénan, Caroline Quintin, Ronan Roussel, Agnès Hartemann, Gilles Montalescot, Pierre‐Yves Marie, Philippe Gabríel Steg, Dominique Le Guludec,
Tópico(s): Advanced X-ray and CT Imaging
2018 - Springer Science+Business Media | Journal of Nuclear Cardiology
Narcisse Komas, S. Monty Ghosh, M. Abdou-Chekaraou, Pierre Pradat, Nasser Al Hawajri, Alexandre Manirakiza, Gina Laure Laghoe, Claudine Békondi, Ségolène Brichler, Jean-Omer Ouavéné, Abdoulaye Sépou, Brice Martial Yambiyo, Jean Chrysostome Gody, Valentin Fikouma, Athénaïs Gerber, Natali Abeywickrama Samarakoon, Dulce Alfaiate, Caroline Scholtès, Nora Martel, Frédéric Le Gal, Hugo Lo Pinto, Ikram Amri, O. Hantz, David Durantel, J. L. Lesbordes, Emmanuel Gordien, Philippe Merle, Tudor Drugan, Christian Trépo, Fabien Zoulim, Jc Cortay, Alan Kay, Paul Dény,
Hepatitis delta virus (HDV) increases morbidity in Hepatitis B virus (HBV)-infected patients. In the mid-eighties, an outbreak of HDV fulminant hepatitis (FH) in the Central African Republic (CAR) killed 88% of patients hospitalized in Bangui. We evaluated infections with HBV and HDV among students and pregnant women, 25 years after the fulminant hepatitis (FH) outbreak to determine (i) the prevalence of HBV and HDV infection in this population, (ii) the clinical risk factors for HBV and/or HDV infections, ...
Tópico(s): Hepatitis C virus research
2018 - Public Library of Science | PLoS neglected tropical diseases
C. Gonthier, Candice Estellat, Catherine Deneux‐Tharaux, Béatrice Blondel, Toni Alfaiate, Thomas Schmitz, Jean‐François Oury, Laurent Mandelbrot, Dominique Luton, Philippe Ravaud, Élie Azria,
Maternal social deprivation is associated with an increased risk of adverse maternal and perinatal outcomes. Inadequate prenatal care utilization (PCU) is likely to be an important intermediate factor. The health care system in France provides essential health services to all pregnant women irrespective of their socioeconomic status. Our aim was to assess the association between maternal social deprivation and PCU. The analysis was performed in the database of the multicenter prospective PreCARE ...
Tópico(s): Birth, Development, and Health
2017 - BioMed Central | BMC Pregnancy and Childbirth
C. Octávio, Daniel Dias‐da‐Costa, J. Alfaiate, Eduardo Júlio,
The use of Fibre Reinforced Concrete (FRC) is gradually wide-spreading due to the significant advantages relatively to Normal Concrete (NC). In the case of steel fibres, the quasi-brittle behaviour of plain concrete structures can be modified into an enhanced ductile behaviour as a direct result of this addition. Since the mechanical properties of both FRC and NC can be significantly different, this work aims at developing a finite element formulation to specifically address the simulation of the ...
Tópico(s): Innovative concrete reinforcement materials
2016 - Elsevier BV | Engineering Fracture Mechanics
Dulce Alfaiate, Julie Lucifora, Natali Abeywickrama Samarakoon, Maud Michelet, Barbara Testoni, Jc Cortay, Camille Sureau, Fabien Zoulim, Paul Dény, David Durantel,
Tópico(s): Liver Disease Diagnosis and Treatment
2016 - Elsevier BV | Antiviral Research
Benoît Coffin, V. Maunoury, François Pattou, Xavier Hébuterne, Stephen H. Schneider, Muriel Coupaye, Séverine Ledoux, F. Iglicki, François Mion, Maud Robert, Emmanuel Disse, J Escourrou, G. Tuyeras, Y. Le Roux, C. Arvieux, Philippe Pouderoux, N. Huten, Toni Alfaiate, David Hajage, Simon Msika,
Tópico(s): Body Contouring and Surgery
2016 - Springer Science+Business Media | Obesity Surgery
Octávio Moura, Marcelino Pereira, Cláudia Alfaiate, Eva Maria Lopes Fernandes, Boavida Fernandes, Susana Engelhard Nogueira, Joana Moreno, Mário R. Simões,
Introduction: This study aimed to investigate the neurocognitive functioning of children with developmental dyslexia (DD) and attention-deficit/hyperactivity disorder (ADHD). Method: Four groups of children between the ages of 8 and 10 years participated in the study: typically developing children (TDC; N = 34), children with DD-only (N = 32), children with ADHD-only (N = 32), and children with DD+ADHD (N = 18). Results: Children with DD and ADHD exhibited significant weaknesses on almost all neurocognitive measures ...
Tópico(s): Children's Physical and Motor Development
2016 - Taylor & Francis | Journal of Clinical and Experimental Neuropsychology
Pedro Neto, J. Alfaiate, Luís Valarinho, João R. Correia, Fernando A. Branco, João Vinagre,
This paper presents an experimental and numerical study about the bond behaviour between glass panes and glass fibre reinforced polymer (GFRP) laminates and the structural response of glass–GFRP beams. For this purpose, tests on glass–GFRP double-lap joints and tests on glass–GFRP hybrid beams were carried out. The finite element method was used and a discrete crack approach based on non-linear fracture mechanics was adopted. The bond between glass and GFRP is modelled by means of zero thickness ...
Tópico(s): Structural Response to Dynamic Loads
2015 - Elsevier BV | Engineering Structures
Dulce Alfaiate, Paul Dény, David Durantel,
An estimated 15–20 million individuals are co-infected by hepatitis B and hepatitis D virus worldwide and are at high risk of developing end-stage liver disease, including hepatocellular carcinoma. While HBV viremia can now be controlled in the vast majority of individuals by nucleoside analogs, leading to a delay of disease progression, HDV treatment has for long relied on the relatively inefficient and not well-tolerated interferon-alpha. While the epidemiology and pathogenesis of the disease ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2015 - Elsevier BV | Antiviral Research
Bruno Fautrel, Thao Pham, Toni Alfaiate, Frédérique Gandjbakhch, Violaine Foltz, Jacques Morel, Emmanuelle Dernis, Philippe Gaudin, Olivier Brocq, Elisabeth Solau‐Gervais, Jean‐Marie Berthelot, Jean‐Charles Balblanc, Xavier Mariette, Florence Tubach,
Tumour necrosis factor (TNF)-blocker tapering has been proposed for patients with rheumatoid arthritis (RA) in remission.The trial aims to compare the effect of progressive spacing of TNF-blocker injections (S-arm) to their maintenance (M-arm) for established patients with RA in remission.The study was an 18-month equivalence trial which included patients receiving etanercept or adalimumab at stable dose for ≥1 year, patients in remission on 28-joint Disease Activity Score (DAS28) for ≥6 months and patients ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2015 - BMJ | Annals of the Rheumatic Diseases
Pedro Neto, J. Alfaiate, Daniel Dias‐da‐Costa, João Vinagre,
A comprehensive literature review shows considerable dispersion in experimental data concerning the material properties of FRP-concrete bond connections. In pure shear models, the direction of FRP loading is usually assumed to be parallel to the axis of the concrete specimen. However, in practice, it is very difficult to prevent a load misalignment. This fact can have important consequences on the derivation of material properties from experimental data. This is why a parametric study is herein ...
Tópico(s): Structural Response to Dynamic Loads
2015 - Elsevier BV | Composite Structures
Daniel Dias‐da‐Costa, Ricardo do Carmo, R. Graça-e-Costa, Jónatas Valença, J. Alfaiate,
The development of lightweight aggregate concrete (LWAC) has brought new design opportunities. The high strength and simultaneous low densities can lead to economically competitive structural solutions, which has immediate impact on seismic construction and on the strengthening of existing structures. Currently, most studies are focused on the mechanical properties and the structural behaviour under ultimate limit states, lacking experimental and numerical data concerning the serviceability of LWAC ...
Tópico(s): Structural Load-Bearing Analysis
2014 - Elsevier BV | Engineering Structures
Pedro Neto, J. Alfaiate, João Vinagre,
In order to characterise the bond between FRP and concrete, several studies have been developed using two-dimensional tools. A considerable dispersion of the parameter values which characterise the bond behaviour has been found in the literature. The main purpose of this study is to investigate whether the non-uniform stress distribution across the width of the FRP–concrete interface can contribute to the dispersion of the shear strength found in the literature. For this purpose, a 3D numerical ...
Tópico(s): Structural Load-Bearing Analysis
2013 - Elsevier BV | Composites Part B Engineering
R. Graça-e-Costa, J. Alfaiate, Daniel Dias‐da‐Costa, Pedro Neto, L.J. Sluys,
Tópico(s): Numerical methods in engineering
2013 - Springer Science+Business Media | International Journal of Fracture