Maurizio Brigotti, Xiaohua He, Domenica Carnicelli, Valentina Arfilli, Elisa Porcellini, Elisabetta Galassi, Pier Luigi Tazzari, Francesca Ricci, Stephanie Patfield, Sara Testa, Fabio Paglialonga, Damiano Picicco, Alfredo Caprioli, Gaia Scavia, Stefano Morabito, Gianluigi Ardissino,
Hemolytic uremic syndrome (HUS), the leading cause of acute renal failure in children (< 3 years), is mainly related to Shiga toxins (Stx)-producing Escherichia coli (STEC) infections. STEC are confined to the gut resulting in hemorrhagic colitis, whereas Stx are delivered in blood to target kidney and brain, with unclear mechanisms, triggering HUS in 5 to 15% of infected children. Stx were found on circulating cells, free in sera (soluble Stx) or in blood cell-derived microvesicles (particulate Stx), whereby ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2019 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis
Salvatore Alaimo, Vincenzo Bonnici, Damiano Cancemi, Alfredo Ferro, Rosalba Giugno, Alfredo Pulvirenti,
The identification of drug-target interactions (DTI) is a costly and time-consuming step in drug discovery and design. Computational methods capable of predicting reliable DTI play an important role in the field. Algorithms may aim to design new therapies based on a single approved drug or a combination of them. Recently, recommendation methods relying on network-based inference in connection with knowledge coming from the specific domain have been proposed. Here we propose a web-based interface ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2015 - Springer Science+Business Media | BMC Systems Biology
Silvia Messina, Claudio Solaro, Isabella Righini, Roberto Bergamaschi, Simona Bonavita, Roberto Bruno Bossio, Vincenzo Brescia Morra, Gianfranco Costantino, Paola Cavalla, Diego Centonze, Giancarlo Comi, Salvatore Cottone, Maura Danni, Ada Francia, Alberto Gajofatto, Claudio Gasperini, Mauro Zaffaroni, Loredana Petrucci, Elisabetta Signoriello, Giorgia Teresa Maniscalco, Gabriella Spinicci, Manuela Matta, Massimiliano Mirabella, Graziella Pedà, Letizia Castelli, Marco Rovaris, Edoardo Sessa, Daniele Spitaleri, Damiano Paolicelli, Alfredo Granata, Mario Zappia, Francesco Patti,
Background The approval of Sativex for the management of multiple sclerosis (MS) spasticity opened a new opportunity to many patients. In Italy, the healthcare payer can be fully reimbursed by the involved pharma company with the cost of treatment for patients not responding after a 4 week (28 days) trial period (Payment by Results, PbR), and 50% reimbursed with the cost of 6 weeks (42 days) treatment for other patients discontinuing (Cost Sharing, CS). The aim of our study was to describe the Sativex ...
Tópico(s): Biosimilars and Bioanalytical Methods
2017 - Public Library of Science | PLoS ONE
Domenico Albano, Antonio Bruno, Federico Bruno, Marco Calandri, Damiano Caruso, Alfredo Clemente, Pietro Coppolino, Diletta Cozzi, Riccardo De Robertis, Francesco Gentili, Irene Grazzini, Maria Laura Jannone, Carlo Liguori, Raffaele Natella, Genny Pace, Alessandro Posa, Paola Scalise, B Accarino, Corrado Bibbolino, Antonio Barile, Roberto Grassi, Carmelo Messina,
To perform an online survey aimed at evaluating the impact of COVID-19 on Italian radiology departments.
Tópico(s): Radiology practices and education
2020 - Springer Science+Business Media | European Radiology
Laura Ricci, Damiano Di Francesco Maesa, Alfredo Favenza, Enrico Ferro,
Several blockchain projects to help against COVID-19 are emerging at a fast pace, showing the potential of this disruptive technology to mitigate the multi-systemic threats the pandemic is posing on all phases of the emergency management and generate value for the economy and society as a whole. This survey investigates how blockchain technology can be useful in the scope of supporting health actions that can reduce the spread of COVID-19 infections and allow a return to normality. Since the prominent ...
Tópico(s): Privacy-Preserving Technologies in Data
2021 - Institute of Electrical and Electronics Engineers | IEEE Access
Tommaso D’Angelo, Andreas Bucher, Lukas Lenga, Christophe Arendt, Julia L. Peterke, Damiano Caruso, Silvio Mazziotti, Alfredo Blandino, Giorgio Ascenti, Mohamed I. A. Othman, Simon S. Martin, Doris Leithner, Thomas J. Vogl, Julian L. Wichmann,
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Springer Science+Business Media | European Radiology
Ciro Esposito, Mario Lima, Girolamo Mattioli, L. Mastroianni, Antonella Centonze, G Monguzzi, L. Montinaro, Giovanna Riccipetitoni, Alfredo Garzi, Antonio Savanelli, Rocco Damiano, Mario Messina, Alessandro Settimi, G. Amici, Vincenzo Jasonni,
... CENTONZE, GIAN LUCA MONGUZZI, LEONARDO MONTINARO, GIOVANNA RICCIPETITONI, ALFREDO GARZI, ANTONIO SAVANELLI, ROCCO DAMIANO, MARIO MESSINA, ALESSANDRO SETTIMI, GIUSEPPE AMICI, and VINCENZO ... LUCA MONGUZZI , LEONARDO MONTINAROLEONARDO MONTINARO , GIOVANNA RICCIPETITONIGIOVANNA RICCIPETITONI , ALFREDO GARZIALFREDO GARZI , ANTONIO SAVANELLIANTONIO SAVANELLI , ROCCO DAMIANOROCCO DAMIANO , MARIO MESSINAMARIO MESSINA , ALESSANDRO SETTIMIALESSANDRO SETTIMI , GIUSEPPE AMICIGIUSEPPE ... author GIOVANNA RICCIPETITONI More articles by this author ALFREDO GARZI More articles by this author ANTONIO SAVANELLI More articles by this author ROCCO DAMIANO More articles by this author MARIO MESSINA More ...
Tópico(s): Minimally Invasive Surgical Techniques
2003 - Lippincott Williams & Wilkins | The Journal of Urology
Vitale Sparacello, Osbjorn M. Pearson, Alfredo Coppa, Damiano Marchi,
Abstract Cross‐sectional geometrical (CSG) properties of an Iron Age Samnite group from the Alfedena necropolis (Abruzzo, Italy, 2600–2400 B.P.) are compared with a Ligurian Neolithic sample (6000–5500 B.P.). In the period under examination, Samnites were organized in a tribal confederation led by patrilinear aristocracies, indicating incipient social stratification. In comparison, Neolithic society lacked clear signs of social hierarchy. The subsistence of both groups was mainly based on pastoralism ...
Tópico(s): Paleopathology and ancient diseases
2010 - Wiley | American Journal of Physical Anthropology
Gian Paolo Rossi, Alfredo Sacchetto, Damiano Rizzoni, Sergio Bova, Enzo Porteri, Giuseppina Mazzocchi, Anna S. Belloni, Meltem Bahçelioğlu, Gastone G. Nussdorfer, Achille C. Pessina,
Abstract —We investigated the role of angiotensin II (Ang II) and endothelin-1 (ET-1) in transgenic (mREN2)27 rats, a model of the monogenic renin-dependent form of severe hypertension and cardiovascular disease. Four-week-old heterozygous male transgenic (mREN2)27 rats (n=24) were matched according to body weight (BW) and blood pressure (BP) and randomly allocated to receive a placebo (group P), the mixed endothelin type A and B receptor antagonist bosentan (100 mg/kg BW PO, group B), the Ang II type 1–specific ...
Tópico(s): Hormonal Regulation and Hypertension
2000 - Lippincott Williams & Wilkins | Arteriosclerosis Thrombosis and Vascular Biology
Elena Corradini, Paolo Ventura, Walter Ageno, Chiara Cogliati, María Lorenza Muiesan, Domenico Girelli, Mario Pirisi, Antonio Gasbarrini, Paolo Angeli, Patrizia Rovere‐Querini, Emanuele Bosi, Moreno Tresoldi, Roberto Vettor, Marco Cattaneo, Fabio Piscaglia, Antonio Brucato, Stefano Perlini, Paolo Martelletti, Roberto Pontremoli, Massimo Porta, Pietro Minuz, Oliviero Olivieri, Giorgio Sesti, Gianni Biolo, Damiano Rizzoni, Gaetano Serviddio, Francesco Cipollone, Davide Grassi, Roberto Manfredini, Guido Moreo, Antonello Pietrangelo, Elisabetta Tombolini, Thomas Teatini, Ernesto Crisafulli, Pier Paolo Sainaghi, Lorenzo Zileri Dal Verme, Salvatore Piano, Rebecca De Lorenzo, Gaetano Arcidiacono, Marco Podda, L. Muratori, Claudia Gabiati, Francesco Salinaro, Michelangelo Luciani, Cecilia Barnini, Stefania Cella, Andrea Dalbeni, Simonetta Friso, Michelangelo Luciani, Filippo Mearelli, Paolo Malerba, Francesco Cavallone, Damiano D’Ardes, Serena Notargiacomo, Alfredo De Giorgi, Marta Mansi, Elena Buzzetti, Andrea Ricci, Francesca Martelli,
During the COVID-19 2020 outbreak, a large body of data has been provided on general management and outcomes of hospitalized COVID-19 patients. Yet, relatively little is known on characteristics and outcome of patients managed in Internal Medicine Units (IMU). To address this gap, the Italian Society of Internal Medicine has conducted a nationwide cohort multicentre study on death outcome in adult COVID-19 patients admitted and managed in IMU. This study assessed 3044 COVID-19 patients at 41 referral ...
Tópico(s): COVID-19 and healthcare impacts
2021 - Springer Science+Business Media | Internal and Emergency Medicine
Federica Cosentino, Vittoria Moscatt, Andrea Marıno, Alessio Pampaloni, Daniele Scuderi, Manuela Ceccarelli, F. Benanti, Maria Gussio, Licia Larocca, Vincenzo Boscia, Giovanni Vinci, Aldo Zagami, Anna Onorante, Gaetano Lupo, Salvatore Torrisi, Silvana Grasso, Roberto Bruno, Carmelo Iacobello, Salvatore Bonfante, Luigi Guarneri, Antonio Cascio, Antonella Di Franco, R Vecchio, Maria Di Rosolini, Alfredo Pulvirenti, Damiano Larnè, Giuseppe Nunnari, Benedetto Maurizio Celesia, Bruno Cacopardo,
Since late December 2019, severe acute respiratory syndrome coronavirus 2 has spread across the world, which resulted in the World Health Organization declaring a global pandemic. Coronavirus disease 2019 (COVID-19) presents a highly variable spectrum with regard to the severity of illness. Most infected individuals exhibit a mild to moderate illness (81%); however, 14% have a serious disease and 5% develop severe acute respiratory distress syndrome (ARDS), requiring intensive care support. The mortality ...
Tópico(s): COVID-19 and Mental Health
2022 - Spandidos Publishing | Biomedical Reports
Marco Carini, Cesare Selli, A. Trippitelli, Paolo Rosi, Damiano Turini,
... Secondary to Renal Trauma Marco Carini, Cesare Selli, Alfredo Trippitelli, Paolo Rosi, and Damiano Turini Marco CariniMarco Carini More articles by this author , Cesare SelliCesare Selli More articles by this author , Alfredo TrippitelliAlfredo Trippitelli More articles by this author , Paolo ... author Cesare Selli More articles by this author Alfredo Trippitelli More articles by this author Paolo Rosi More articles by this author Damiano Turini More articles by this author Expand All ...
Tópico(s): Ureteral procedures and complications
1981 - Lippincott Williams & Wilkins | The Journal of Urology
Maria Antonietta Coschignano, Carolina De Ciuceis, Claudia Agabiti-Rosei, Valeria Brami, Claudia Rossini, Giulia Chiarini, Paolo Malerba, Francesca Famà, Deborah Cosentini, María Lorenza Muiesan, Massimo Salvetti, Alina Petelca, Sara Capellini, Chiara Arnoldi, Matteo Nardin, Salvatore Grisanti, Damiano Rizzoni, Alfredo Berruti, Anna Paini,
Objective: Antiangiogenic therapies (tyrosine kinase inhibitors-TKI and direct anti-VEGF monoclonal antibodies) are being increasingly used in the treatment of solid tumors; hypertension represents a common side effect of these agents. Several mechanisms are involved in the development of hypertension, including microvascular rarefaction and other microvascular alterations. Therefore, the aim of our study was to evaluate whether TKI and direct anti-VEGF agents may affect the structure of retinal ...
Tópico(s): Retinal Imaging and Analysis
2021 - Frontiers Media | Frontiers in Cardiovascular Medicine
Gian Paolo Rossi, Sergio Bova, Alfredo Sacchetto, Damiano Rizzoni, Enrico Agabiti‐Rosei, Giuliano Neri, G. G. Nussdorfer, A. C. Pessina,
We investigated the effects of MDL-100,240 in a transgenic rat model (TGRen2) of hypertension with severe cardiovascular damage (CVD) due to enhanced tissue synthesis of angiotensin II (Ang II).
Tópico(s): Hormonal Regulation and Hypertension
2002 - Oxford University Press | American Journal of Hypertension
Michele Ammendola, Ilaria Marech, Giuseppe Sammarco, Valeria Zuccalà, Maria Luposella, Nicola Zizzo, Rosa Patruno, Alberto Maria Crovace, Eustachio Ruggieri, Alfredo Zito, Cosmo Damiano Gadaleta, Rosario Sacco, Girolamo Ranieri,
While gastric cancer is a well established angiogenesis driven tumor, no data has been published regarding angiogenesis stimulated by mast cells (MCs) positive for tryptase in bone metastases from gastric cancer patients (BMGCP). It is well established that MCs play a role in immune responses and more recently it was demonstrated that MCs have been involved in tumor angiogenesis. We analyzed infiltrating MCs and neovascularization in BMGCP diagnosed by histology. A series of 15 stage T3-4N2-3M1 (by ...
Tópico(s): Hops Chemistry and Applications
2015 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Piero Ferollà, M.P. Brizzi, Tim Meyer, Wasat Mansoor, Julien Mazières, Christine Do Cao, H. Léna, Alfredo Berruti, V. Damiano, Wieneke A. Buikhuisen, Miona Stankovic, Neha Singh, E Chiodini, Gabriella Gislimberti, Kjell Öberg, Éric Baudin,
Advanced lung/thymus carcinoid is an area of high unmet medical need. In recent phase 3 RADIANT-4 study, everolimus (E) showed progression-free survival (PFS) benefit in patients (pts) with GI/lung NET. Pasireotide LAR (P, somatostatin analog [SSA]), has also shown potential antitumor activity in previous studies in NET. This phase 2 study evaluated efficacy and safety of E, P, and P + E in pts withprogressive carcinoids of lung/thymus. Adult pts with metastatic RECIST progressive carcinoids of lung/thymus ...
Tópico(s): Neuroblastoma Research and Treatments
2016 - Elsevier BV | Annals of Oncology
Piero Ferollà, Maria Pia Brizzi, Tim Meyer, Wasat Mansoor, Julien Mazières, Christine Do Cao, H. Léna, Alfredo Berruti, Vincenzo Damiano, Wieneke A. Buikhuisen, Henning Grønbæk, Catherine Lombard‐Bohas, Christian Grohé, Vincenzo Minotti, Marcello Tiseo, Javier de Castro, Nicholas Reed, Gabriella Gislimberti, Neha Singh, Miona Stankovic, Kjell Öberg, Éric Baudin,
There are no data from prospective studies focused exclusively on patients with advanced lung and thymic carcinoids. We aimed to assess the efficacy and safety of long-acting pasireotide and everolimus, administered alone or in combination, in patients with advanced carcinoids of the lung or thymus.LUNA was a prospective, multicentre, randomised, open-label, phase 2 trial of adult patients (aged >18 years) with advanced (unresectable or metastatic), well differentiated carcinoid tumours of the lung ...
Tópico(s): Pituitary Gland Disorders and Treatments
2017 - Elsevier BV | The Lancet Oncology
Ilaria Marech, Rosa Patruno, Nicola Zizzo, C. Gadaleta, Marcello Introna, Alfredo Francesco Zito, Cosmo Damiano Gadaleta, Girolamo Ranieri,
Masitinib mesylate (AB1010) is a novel potent and selective tyrosine kinase inhibitor, targeting mainly wild-type and mutated c-Kit receptor (c-KitR), Platelet Derived Growth Factor Receptor-alfa/beta (PDGFRa/ß), Lymphocyte-specific kinase (Lck), Lck/Yes-related protein (LYn), Fibroblast Growth Factor Receptor 3 (FGFR3) and Focal Adhesion Kinase (FAK). It is the first anticancer therapy approved in veterinary medicine for the treatment of unresectable canine mast cell tumors (CMCTs), harboring activating ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2013 - Elsevier BV | Critical Reviews in Oncology/Hematology
Marco Poeta, Valentina Cioffi, Vittoria Buccigrossi, Francesco Corcione, Roberto Peltrini, Angela Amoresano, Fabio Magurano, Maurizio Viscardi, Giovanna Fusco, Antonietta Tarallo, Carla Damiano, Andrea Lo Vecchio, Eugenia Bruzzese, Alfredo Guarino,
The pathophysiology of SARS-CoV-2-associated diarrhea is unknown. Using an experimental model validated for rotavirus-induced diarrhea, we investigated the effects of SARS-CoV-2 on transepithelial ion fluxes and epithelial integrity of human intestinal cells. The effect of the antidiarrheal agent diosmectite on secretion was also evaluated following its inclusion in COVID-19 management protocols.We evaluated electrical parameters (intensity of short-circuit current [Isc] and transepithelial electrical ...
Tópico(s): Long-Term Effects of COVID-19
2022 - Elsevier BV | Heliyon
Tommaso D’Angelo, Lukas Lenga, Christophe Arendt, Andreas Bucher, Julia L. Peterke, Damiano Caruso, Silvio Mazziotti, Giorgio Ascenti, Alfredo Blandino, Mohamed I. A. Othman, Simon S. Martin, Moritz H. Albrecht, Boris Bodelle, Thomas J. Vogl, Julian L. Wichmann,
Purpose Dedicated post-processing of dual-energy computed tomography angiography (DE-CTA) datasets has been shown to allow for increased vascular contrast. The goal of our study was to define optimal window settings for displaying virtual monoenergetic images (VMI) reconstructed from dual-energy carotid and cerebrovascular DE-CTA. Methods Fifty-seven patients who underwent clinically-indicated carotid and cerebrovascular third-generation dual-source DE-CTA were retrospectively evaluated. Standard ...
Tópico(s): Cardiac Imaging and Diagnostics
2020 - Elsevier BV | European Journal of Radiology
Maria Pia Sormani, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Antonio Zito, Paolo Confalonieri, Girolama Alessandra Marfia, Paola Perini, Matilde Inglese, Maria Trojano, Vincenzo Brescia Morra, Gioacchino Tedeschi, Gıancarlo Comı, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Beatrice Maria Allegri Rossi, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, A. Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Caniatti, Roberto Cantello, Ruggero Capra, Rocco Capuano, Patrizia Carta, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Grazia Chisari, Raffaella Clerici, Marinella Clerico, Gaia Cola, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Maura Danni, Alessia d’Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Stefano, Marco Della Cava, Mario Di Napoli, Alessia Di Sapio, Renato Docimo, A Dutto, Luana Evangelista, Salvatore Fanara, Ferraro Diana, Maria Teresa Ferrò, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Daniele Imperiale, María Teresa Infante, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, M.R. L'Episcopo, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, F. Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile‐Orazio, Agostino Nozzolillo, Marco Onofrj, Doriana Landi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Elisabetta Pedrazzoli, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M. Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Giuditta Ilaria Scarano, Valentina Scarano, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Consiglia Trotta, G. Turano, Monica Ulivelli, Valentino Manzo, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Luigi Zuliani,
It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19-related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population.Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population- ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Wolters Kluwer | Neurology Neuroimmunology & Neuroinflammation
Simona Sacco, Stefano Ricci, Raffaele Ornello, Paolo Eusebi, Luca Petraglia, Danilo Toni, Eugenia Rota, Gianluca Bruzzone, Lucia Testa, Roberta Bongioanni, Mara Rosso, Carmelo Labate, Roberto Tarletti, Roberto Cantello, Thomas Fleetwood, Fabio Melis, Daniele Imperiale, Salvatore Amarù, Monica Reggiani, Luigi Ruiz, Elia Cipriano, Delfina Ferrandi, Patrizia Julita, Liana Africa, Piero Meinieri, Maria Federica Grasso, Serena Servo, Roberto Cavallo, Gigliola Chianale, Andrea Naldi, Paolo Cerrato, Elisa Rubino, Alessia Giossi, Valentina Puglisi, Luisa Vinciguerra, Ignazio Santilli, Bianca Maria Bordo, Simona Marcheselli, Julia Bottini, Caterina Mariotto D’Alessandro, Giuseppe Micieli, Anna Cavallini, Isabella Canavero, Francesco Muscia, Graziamaria Nuzzaco, Alfonso Ciccone, Giorgio Silvestrelli, Andrea Salmaggi, Davide Sangalli, Carla Zanferrari, Simona Fanucchi, Michela Ranieri, Simone Beretta, Carlo Ferrarese, Francesco Pasini, Francesco Santangelo, Nicoletta Checcarelli, Sandro Beretta, Paola Bazzi, M. Camerlingo, Marcello Tognozzi, Giorgio Caneve, Alessandro Adami, R. Quatrale, Adriana Critelli, Luigi Bartolomei, Maela Masato, Francesco Perini, Antonella Boni, Caterina Disco, Claudio Baracchini, Alessio Pieroni, Roberto L’Erario, Monia Russo, Alberto Polo, Alessandra Danese, Luca Valentinis, Antonio Baldi, Simone Tonello, Francesco Paladin, Agnese Tonon, Bruno Bonetti, Manuel Cappellari, Francesco Teatini, Roberto Currò Dossi, Enrica Franchini, Bruno Giometto, Valeria Bignamini, Paolo Manganotti, Marcello Naccarato, Gian Luigi Gigli, Simone Lorenzut, Giovanni Merlino, Mariarosaria Valente, Michele Rana, Carolina Gentile, Tiziana Tassinari, Annalisa Sugo, Valentina Saia, Maurizio Balestrino, Alberto Coccia, Cinzia Finocchi, Franco Valzania, Marialuisa Zedde, Giulia Toschi, Marco Longoni, Matteo Paolucci, V. Tugnoli, Pietro Querzani, Marina Padroni, Stefano Meletti, Guido Bigliardi, Maria Luisa Dall’Acqua, Andrea Zini, Mauro Gentile, Ludovica Migliaccio, Alberto Chiti, Rossana Tassi, Giuseppe Martini, Patrizia Nencini, Maria Lamassa, Michelangelo Mancuso, Giovanni Orlandi, Elena Ferrari, Roberto Marconi, Simone Gallerini, Vincenzo Groggia, Gino Volpi, C. Menichetti, Stefano Spolveri, Mauro Silvestrini, Giovanna Viticchi, Laura Buratti, Giuseppe Pelliccioni, Eleonora Potente, Tatiana Mazzoli, E Marsili, Silvia Cenciarelli, Antonella Picchioni, Franco Costantini, Carlo Colosimo, Maurizio Paciaroni, Valeria Caso, Maurizia Rasura, Mario Beccia, Nicola Falcone, Marisa Di Stefano, Emanuela Cecconi, Sabrina Anticoli, Francesca Romana Pezzella, Marilena Mangiardi, M Plocco, Maria Magarelli, Carlo Emanuele Saggese, Irene Berto, Maria Concetta Altavista, Cinzia Roberti, Marina Diomedi, Fabrizio Sallustio, Alessandro Rocco, Letizia Maria Cupini, Novella Bonaffini, Maria Vittoria De Angelis, Anna Digiovanni, Marianna Gabriella Rispoli, Berardino Orlandi, Federica De Santis, Enrico Colangeli, Francesco Di Blasio, Caterina Di Carmine, Pierluigi Tocco, Maurizio Melis, Jessica Moller, Valeria Saddi, Antonio Manca, Antonio Baule, Antonello Caddeo, Nicola Iorio, Rosa Napoletano, Maria Di Gregorio, Giampiero Volpe, Florindo d’Onofrio, Daniele Spitaleri, Leonardo Barbarini, Gaetano Barbagallo, Marcella Caggiula, Bonaventura Ardito, Domenico Di Noia, Pietro Di Viesti, Maurizio Leone, Vincenzo Inchingolo, Marco Petruzzellis, Federica Rizzo, Mariantonietta Savarese, Alfredo Petrone, Franco Galati, Luciano Arcudi, Damiano Branca, Paolo Aridon, Valentina Arnao, Rosa Fortunata Musolino, Cristina Dell’Aera, Isabella Francalanza, Luigi Maria Grimaldi, Valentina Arnao, Matilde Gammino, Antonello Giordano, Giuseppe Zelante, Enzo Sanzaro, Antonio Gasparro,
We aimed to investigate the rate of hospital admissions for cerebrovascular events and of revascularization treatments for acute ischemic stroke in Italy during the coronavirus disease 2019 (COVID-19) outbreak.
Tópico(s): Climate Change and Health Impacts
2020 - Lippincott Williams & Wilkins | Stroke
Rosaria Maddalena Ruggeri, Alfredo Campennì, Massimiliano Siracusa, Giuseppe Frazzetto, Damiano Gullo,
Subacute thyroiditis (SAT) is an inflammatory thyroid disorder of viral origin, generally preceded by an upper respiratory tract infection. Since the disorder is self-limiting, it is frequently underdiagnosed. However, the disease should not be overlooked since the associated thyrotoxicosis may worsen the clinical course of concomitant disorders (e.g., respiratory distress) and long-term sequelae, such as autoimmune hypothyroidism, have been reported. Here we describe a woman who developed SAT with ...
Tópico(s): COVID-19 Clinical Research Studies
2020 - Springer Science+Business Media | HORMONES
Girolamo Ranieri, Luciano Grammatica, Rosa Patruno, Alfredo Zito, Paolo Valerio, S. Iacobellis, Cosmo Damiano Gadaleta, Giampietro Gasparini, Doménico Ribatti,
Abstract Thymidine Pi deoxyribosyltransferase (TP) is an enzyme involved in DNA synthesis up‐regulated in tumours and it is also a pro‐angiogenic factor. TP cannot activate capecitabine, because capecitabine first needs conversion by carboxylesterase and cytidine deaminase into 5‐deoxy‐fluorouridine. This compound can be activated by TP to 5‐fluorouracil (5‐FU). Although TP is not necessary for 5‐FU toxicity, experimental data suggest that high levels of TP correlate with an enhanced response to 5‐ ...
Tópico(s): Acute Myeloid Leukemia Research
2007 - Wiley | Journal of Cellular and Molecular Medicine
Niccolò Lombardi, Giada Crescioli, Monica Simonetti, Ettore Marconi, Alfredo Vannacci, Alessandra Bettiol, Damiano Parretti, Claudio Cricelli, Francesco Lapi,
Combination therapies are often needed to modify the concomitant risk factors for cardiovascular disease. Nonadherence to cardiovascular medications is a relevant concern, especially in polytherapy. We conducted a population-based, cohort study with the aim of quantifying the level of adherence and its related determinants in patients exposed to free 3-drug combination therapies, namely concurrent use of angiotensin-converting-enzyme inhibitor (ACEi), calcium channel blocker (CCB), and statin or of ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - Elsevier BV | The American Journal of Cardiology
Michela Russo, Stefania Cocco, Agnese Secondo, Annagrazia Adornetto, Antonella Bassi, Alfredo Nunziata, Giuliano Polichetti, Bruna De Felice, Simona Damiano, Rosalba Serù, Paolo Mondola, Gianfranco Di Renzo,
Tópico(s): Advanced Glycation End Products research
2009 - Springer Science+Business Media | Neurotoxicity Research
Vincenzo Di Nunno, Caterina Giannini, Sofia Asioli, Alfredo Conti, Julia Furtner, Damiano Balestrini, Alicia Tosoni,
Background: Meningiomas are the most common primary central nervous system malignancies accounting for 36% of all intracranial tumors. However, only 1% of meningioma is classified as malignant (anaplastic) meningioma. Due to their rarity, clinical management of these tumors presents several gaps. Methods: We carried out a narrative review aimed to investigate current knowledge of anaplastic meningioma focusing on their pathological and radiological diagnosis, molecular assessment, and loco-regional ...
Tópico(s): Head and Neck Surgical Oncology
2022 - Multidisciplinary Digital Publishing Institute | Cancers
Produção Nacional
Revisado por pares
Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Gıancarlo Comı, Mario Alberto Battaglia, Francesco Patti, Yára Dadalti Fragoso, Sedat Şen, Aksel Sıva, Roberto Furlan, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, R. Allegri, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario Alberto Battaglia, A. Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Caniatti, Roberto Cantello, Marco Capobianco, Ruggero Capra, Rocco Capuano, Luca Carmisciano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Grazia Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Gıancarlo Comı, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Cinzia Cordioli, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Maura Danni, Alessia d’Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Marco Della Cava, Mario Di Napoli, Alessia Di Sapio, Renato Docimo, A Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Paolo Immovilli, Daniele Imperiale, María Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Rita L’Episcopo Maria, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Mancinelli, Luca Mancinelli, Paolo Manganotti, Teresa Giorgia Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Alessandra Girolama Marfia, F. Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita Monti Bragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile‐Orazio, Agostino Nozzolillo, Marco Onofrj, Doriana Landi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Francesco Patti, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M. Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Marta Radaelli, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Marco Salvetti, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Ilaria Scarano Giuditta, Valentina Scarano, Irene Schiavetti, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Maria Pia Sormani, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Laura Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Gioacchino Tedeschi, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trojano, Maria Consiglia Trotta, G. Turano, Monica Ulivelli, Valentino Manzo, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani,
The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available.To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test.We evaluated the association between positive serological ...
SAGE Publishing | Multiple Sclerosis Journal
Produção Nacional
Revisado por pares
Yuxiang Jiang, Tal Oron, Wyatt T. Clark, Asma Bankapur, Daniel D’Andrea, Rosalba Lepore, Christopher S. Funk, Indika Kahanda, Karin Verspoor, Asa Ben‐Hur, Da Chen Emily Koo, Duncan Penfold-Brown, Dennis Shasha, Noah Youngs, Richard Bonneau, Alexandra J. Lin, Sayed Mohammad Ebrahim Sahraeian, Pier Luigi Martelli, Giuseppe Profiti, Rita Casadio, Renzhi Cao, Zhaolong Zhong, Jianlin Cheng, Adrian Altenhoff, Nives Škunca, Christophe Dessimoz, Tunca Doğan, Kai Hakala, Suwisa Kaewphan, Farrokh Mehryary, Tapio Salakoski, Filip Ginter, Hai Fang, Ben Smithers, Matt E. Oates, Julian Gough, Petri Törönen, Patrik Koskinen, Liisa Holm, Ching-Tai Chen, Wen−Lian Hsu, Kevin Bryson, Domenico Cozzetto, Federico Minneci, David T. Jones, Samuel Chapman, Dukka Bkc, Ishita Khan, Daisuke Kihara, Dan Ofer, Nadav Rappoport, Amos Stern, Elena Cibrián–Uhalte, Paul Denny, Rebecca E. Foulger, Reija Hieta, Duncan Legge, Ruth C. Lovering, Michele Magrane, Anna N. Melidoni, Prudence Mutowo, Klemens Pichler, Aleksandra Shypitsyna, Biao Li, Pooya Zakeri, Sarah ElShal, Léon-Charles Tranchevent, Sayoni Das, Natalie L. Dawson, David Lee, Jonathan Lees, Ian Sillitoe, Prajwal Bhat, Tamás Nepusz, Alfonso E. Romero, Rajkumar Sasidharan, Haixuan Yang, Alberto Paccanaro, Jesse Gillis, Adriana E. Sedeño-Cortés, Paul Pavlidis, Shou Feng, Juan Miguel Cejuela, Tatyana Goldberg, Tobias Hamp, Lothar Richter, Asaf Salamov, Toni Gabaldón, Marina Marcet‐Houben, Fran Supek, Qingtian Gong, Wei Ning, Yuanpeng Zhou, Weidong Tian, Marco Falda, Paolo Fontana, Enrico Lavezzo, Stefano Toppo, Carlo Ferrari, Manuel Giollo, Damiano Piovesan, Silvio C. E. Tosatto, Ángela del Pozo, José M. Fernández, Paolo Maietta, Alfonso Valencia, Michael L. Tress, Alfredo Benso, Stefano Di Carlo, Gianfranco Politano, Alessandro Savino, Hafeez Ur Rehman, Matteo Ré, Marco Mesiti, Giorgio Valentini, Joachim W. Bargsten, Aalt D. J. van Dijk, Branislava Gemović, Sanja Glišić, Vladimir Perović, Veljko Veljković, Nevena Veljković, Danillo C. Almeida-e-Silva, Ricardo Z. N. Vêncio, Malvika Sharan, Jörg Vogel, Lakesh Kansakar, Shanshan Zhang, Slobodan Vučetić, Zheng Wang, Michael J.E. Sternberg, Mark N. Wass, Rachael P. Huntley, María Martin, Claire O’Donovan, Peter N. Robinson, Yves Moreau, Anna Tramontano, Patricia C. Babbitt, Steven E. Brenner, Michal Linial, Christine Orengo, Burkhard Rost, Casey S. Greene, Sean D. Mooney, Iddo Friedberg, Predrag Radivojac,
A major bottleneck in our understanding of the molecular underpinnings of life is the assignment of function to proteins. While molecular experiments provide the most reliable annotation of proteins, their relatively low throughput and restricted purview have led to an increasing role for computational function prediction. However, assessing methods for protein function prediction and tracking progress in the field remain challenging.We conducted the second critical assessment of functional annotation ( ...
Tópico(s): Computational Drug Discovery Methods
2016 - BioMed Central | Genome biology
Giuseppe Milano, Antonio Gigante, Alfredo Schiavone Panni, Pier Damiano Mulas, C. Fabbriciani,
Tópico(s): Sports injuries and prevention
2000 - Springer Science+Business Media | Knee Surgery Sports Traumatology Arthroscopy