W. Lionel Branche, J. E. R. Taylor, Mrs. H. Miller, Alice Maria, F. H. Johnson, J. T. Roberts, J. N. Lube Metzger,
Frontmatter: Sierra Leone Weekly News, The Sierra Leone Weekly News. Display ads: Mr. A. Lisk-Carew, The Don Association, Multiple Display Advertisements, ...
1907 - Gale Group | NCCO EuropeAfrica
Produção Nacional
Revisado por pares
Gdayllon Cavalcante Meneses, Pedro Eduardo Andrade de Carvalho Gomes, Gabriela Studart Galdino, Gabriela Freire Bezerra, Ranieri Sales de Souza Santos, Alice Maria Costa Martins, Geraldo Bezerra da Silva, Alexandre Braga Libório, Roberto da Justa Pires Neto, Elizabeth De Francesco Daher,
... more papers by this authorAlice Maria Costa Martins, Alice Maria Costa Martins Pharmacology Post-Graduate Program, Federal University ... more papers by this authorAlice Maria Costa Martins, Alice Maria Costa Martins Pharmacology Post-Graduate Program, Federal University ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2022 - Wiley | Tropical Medicine & International Health
G. H. Jones, C. Snodgrass, C. Tubiana, M. Küppers, Hideyo Kawakita, L. M. Lara, Jessica Agarwal, Nicolás André, N. Attree, U. Auster, S. Bagnulo, Michele T. Bannister, Arnaud Beth, Neil E. Bowles, A. J. Coates, L. Colangelí, C. Corral van Damme, V. Da Deppo, Johan De Keyser, Vincenzo Della Corte, N. J. T. Edberg, M. R. El‐Maarry, Sara Faggi, M. Fulle, Ryu Funase, M. Galand, Charlotte Goetz, O. Groussin, Aurélie Guilbert-Lepoutre, Pierre Henri, Satoshi Kasahara, Ákos Keresztúri, M. Kidger, Matthew M. Knight, Rosita Kokotanekova, Ivana Kolmašová, Konrad J. Kossacki, E. Kührt, Yuna G. Kwon, F. La Forgia, A. C. Levasseur-Regourd, M. Lippi, A. Longobardo, Raphael Marschall, Marek Morawski, Olga Muñoz, Antti Näsilä, H. Nilsson, Cyrielle Opitom, Mihkel Pajusalu, A. Pommerol, Lubomír Přech, N. Rando, F. Ratti, Hanna Rothkaehl, A. Rotundi, M. Rubı́n, Naoya Sakatani, Joan-Pau Sanchez Cuartielles, Cyril Simon Wedlund, A. Stankov, N. Thomas, I. Tóth, Gerónimo Villanueva, Jean‐Baptiste Vincent, M. Volwerk, P. Wurz, Arno Wielders, Kazuo Yoshioka, Konrad Aleksiejuk, F. Álvarez, C. Amoros, Shahid Aslam, B. Atamaniuk, Jędrzej Baran, Tomasz Barciński, T. Beck, Thomas Behnke, M. Berglund, Ivano Bertini, Marcin Bieda, Piotr Bińczyk, Martin-Diego Busch, Andrei Cacovean, M. T. Capria, C. Carr, J. M. Castro, Matteo Ceriotti, Paolo Chioetto, Agata Chuchra-Konrad, Lorenzo Cocola, Fabrice Colin, Chiaki Crews, V. Cripps, E. Cupido, Alberto Dassatti, B. Davidsson, Thierry De Roche, Jan Deca, Simone Del Togno, Frederik Dhooghe, K. L. Donaldson Hanna, A. I. Eriksson, A. Fedorov, E. Fernández-Valenzuela, Stefano Ferretti, Johan Floriot, Fabio Frassetto, Jesper Fredriksson, Philippe Garnier, Dorota Gaweł, V. Génot, T. Gerber, Karl‐Heinz Glaßmeier, Mikael Granvik, B. Grison, H. Gunell, Tedjani Hachemi, Christian Hagen, Rajkumar Hajra, Yuki Harada, J. Hasiba, Nico Haslebacher, Miguel Luis Herranz De La Revilla, Daniel Hestroffer, T. Hewagama, Carrie E. Holt, S. F. Hviid, Iaroslav Iakubivskyi, L. Inno, P. G. J. Irwin, Stavro Ivanovski, Jiri Jansky, I. Jernej, H. Jeszenszky, J. A. Juárez Jiménez, L. Jordá, Mihkel Kama, Shingo Kameda, Michael S. P. Kelley, K. Klepacki, T. Kohout, Hirotsugu Kojima, Tomasz Kowalski, Masaki Kuwabara, Michał Ładno, Gunter Laky, H. Lämmer, Radek Lán, B. Lavraud, M. Lazzarin, Olivier Le Duff, Qiu-Mei Lee, Cezary Lesniak, Zoe Lewis, Zhong-Yi Lin, Tim Lister, S. C. Lowry, W. Magnes, Johannes Markkanen, Ignacio Martinez Navajas, Zita Martins, Ayako Matsuoka, Barbara Matyjasiak, C. Mazelle, E. Mazzotta Epifani, Mirko Meier, H. Michaelis, M. Micheli, A. Migliorini, Aude-Lyse Millet, F. Moreno, S. Mottola, Bruno Moutounaick, K. Muinonen, Daniel Müller, Go Murakami, Naofumi Murata, Kamil Myszka, S. Nakajima, Zoltán Németh, Artiom Nikolajev, Simone Nordera, D. Ohlsson, Aire Olesk, H. Öttacher, Naoya Ozaki, C. Oziol, Manish Patel, Aditya Savio Paul, Antti Penttilä, Claudio Pernechele, Joakim Peterson, Enrico Petraglio, Alice Maria Piccirillo, Ferdinand Plaschke, Szymon Polak, Frank Postberg, Herman Proosa, S. Protopapa, W. Puccio, Sylvain Ranvier, Sean N. Raymond, Ingo Richter, Martin Rieder, Roberto Rigamonti, Irene Ruiz-Rodriguez, O. Santolı́k, Takahiro Sasaki, R. Schrödter, K. A. Shirley, Andris Slavinskis, Bálint Sódor, J. Souček, Peter Stephenson, Linus Leo Stöckli, Paweł Szewczyk, Gabor Troznai, Luděk Uhlíř, Naoto Usami, Aris Valavanoglou, Jakub Vaverka, Wei Wang, Xiao-Dong Wang, Gaëtan Wattieaux, Martin Wieser, Sebastián Wolf, Hajime Yano, Ichiro Yoshikawa, Vladimir Zakharov, Tomasz Zawistowski, Paola Zuppella, G. Rinaldi, Hantao Ji,
Abstract Here we describe the novel, multi-point Comet Interceptor mission. It is dedicated to the exploration of a little-processed long-period comet, possibly entering the inner Solar System for the first time, or to encounter an interstellar object originating at another star. The objectives of the mission are to address the following questions: What are the surface composition, shape, morphology, and structure of the target object? What is the composition of the gas and dust in the coma, its ...
Tópico(s): Planetary Science and Exploration
2024 - Springer Science+Business Media | Space Science Reviews
C Bravo, Alice Maria Giani, Jesus Madero-Perez, Zeping Zhao, Yuansong Wan, Avi J. Samelson, Man Ying Wong, Alessandro Evangelisti, Ethan Cordes, Li Fan, Pearly Ye, Daphne Zhu, Tatyana Pozner, Maria Mercédes, Tark Patel, Allan Yarahmady, Gillian Carling, Fredrik Sterky, Virginia M.‐Y. Lee, Edward B. Lee, Michael DeTure, Dennis W. Dickson, Manu Sharma, Sue‐Ann Mok, Wenjie Luo, Mingrui Zhao, Martin Kampmann, Shiaoching Gong, Li Gan,
Tauopathies are age-associated neurodegenerative diseases whose mechanistic underpinnings remain elusive, partially due to a lack of appropriate human models. Here, we engineered human induced pluripotent stem cell (hiPSC)-derived neuronal lines to express 4R Tau and 4R Tau carrying the P301S MAPT mutation when differentiated into neurons. 4R-P301S neurons display progressive Tau inclusions upon seeding with Tau fibrils and recapitulate features of tauopathy phenotypes including shared transcriptomic ...
Tópico(s): Medicinal Plants and Neuroprotection
2024 - Cell Press | Cell
Delphine Larivière, Linelle Abueg, Nadolina Brajuka, Cristóbal Gallardo Alba, Björn Grüning, Byung June Ko, Alexander Ostrovsky, Marc Palmada‐Flores, Brandon D. Pickett, K Siddique-e Rabbani, Agostinho Antunes, Jennifer Balacco, Mark Chaisson, Haoyu Cheng, Joanna Collins, Mélanie Couture, Alexandra A. Denisova, Olivier Fédrigo, Guido Roberto Gallo, Alice Maria Giani, Grenville MacDonald Gooder, Kathleen Horan, Nivesh Jain, Cassidy Johnson, Heebal Kim, Chul Lee, Tomàs Marquès‐Bonet, Brian I. O’Toole, Arang Rhie, Simona Secomandi, Marcella Sozzoni, Tatiana Tilley, Marcela Uliano‐Silva, Marius van den Beek, Robert W. Williams, Robert M. Waterhouse, Adam M. Phillippy, Erich D. Jarvis, Michael C. Schatz, Anton Nekrutenko, Giulio Formenti,
Scalable, accessible and reproducible reference genome assembly and evaluation in Galaxy T he Earth BioGenome Project aims to produce reference genomes for all ~1.8 million known eukaryotic species over the next decade [1][2][3][4] .Achieving this goal will require the current pace of reference genome production to increase by at least two orders of magnitude 1 .Automation of the assembly process with a pipeline that is widely accessible to any research group will be required to achieve this speed-up. ...
Tópico(s): Chromosomal and Genetic Variations
2024 - Nature Portfolio | Nature Biotechnology
Flora Tassone, Dragana Protić, Emily G. Allen, Alison D. Archibald, Anna Baud, Ted W. Brown, Dejan B. Budimirovic, Jonathan Cohen, Brett D. Dufour, Rachel Eiges, Nicola Elvassore, Lidia V. Gabis, Samantha J. Grudzien, Deborah A. Hall, David Hessl, Abigail L. Hogan, Jessica Ezzell Hunter, Peng Jin, Poonnada Jiraanont, Jessica Klusek, R. Frank Kooy, Claudine M. Kraan, Cecilia Laterza, Andrea Lee, Karen Lipworth, Molly Losh, Danuta Z. Loesch, Reymundo Lozano, Marsha R. Mailick, Apostolos Manolopoulos, Verónica Martínez‐Cerdeño, Yingratana McLennan, Robert M. Miller, Federica Alice Maria Montanaro, Matthew W. Mosconi, Sarah Nelson Potter, Melissa Raspa, Susan M. Rivera, Katharine E. Shelly, Peter K. Todd, Katarzyna Tutak, Jun Yi Wang, Anne Wheeler, Tri Indah Winarni, Marwa Zafarullah, Randi J. Hagerman,
The premutation of the fragile X messenger ribonucleoprotein 1 (
Tópico(s): Genetics and Neurodevelopmental Disorders
2023 - Multidisciplinary Digital Publishing Institute | Cells
Kathrin Theißinger, Carlos Fernandes, Giulio Formenti, Iliana Bista, Paul R. Berg, Christoph Bleidorn, Aureliano Bombarely, Angelica Crottini, Guido Roberto Gallo, José A. Godoy, Sissel Jentoft, Joanna Malukiewicz, Alice Mouton, Rebekah A. Oomen, Sadye Paez, Per J. Palsbøll, Christophe Pampoulie, María José Ruiz‐López, Simona Secomandi, Hannes Svardal, Constantina Theofanopoulou, Jan de Vries, Ann‐Marie Waldvogel, Guojie Zhang, Erich D. Jarvis, Miklós Bálint, Claúdio Ciofi, Robert M. Waterhouse, Camila J. Mazzoni, Jacob Höglund, Sargis A. Aghayan, Tyler Alioto, Isabel Almudí, Nadir Álvarez, Paulo C. Alves, Isabel R. Amorim, Agostinho Antunes, Paula Arribas, Petr Baldrián, Giorgio Bertorelle, Astrid Böhne, Andrea Bonisoli‐Alquati, Ljudevit Luka Boštjančić, Bastien Boussau, Catherine Breton, Elena Bužan, Paula F. Campos, Carlos Carreras, L. Filipe C. Castro, Luis J. Chueca, Fedor Čiampor, Elena Conti, Robert Cook‐Deegan, Daniel Croll, Mónica V. Cunha, Frédéric Delsuc, Alice B. Dennis, Dimitar Dimitrov, Rui Faria, Adrien Favre, Olivier Fédrigo, Rosa Fernández, Gentile Francesco Ficetola, Jean‐François Flot, Toni Gabaldón, D. Agius, Alice Maria Giani, M. Thomas P. Gilbert, Tine Grebenc, Katerina Guschanski, Romain Guyot, Bernhard Hausdorf, Oliver Hawlitschek, Peter D. Heintzman, Berthold Heinze, Michael Hiller, Martin Husemann, Alessio Iannucci, Iker Irisarri, Kjetill S. Jakobsen, Peter Klinga, Agnieszka Kloch, Claudius F. Kratochwil, Henrik Kusche, Kara K S Layton, Jennifer A. Leonard, Emmanuelle Lerat, Gianni Liti, Tereza Manousaki, Tomàs Marquès‐Bonet, Pável Matos‐Maraví, Michael Matschiner, Florian Maumus, Ann M. Mc Cartney, Shai Meiri, José Melo‐Ferreira, Ximo Mengual, Michael T. Monaghan, Matteo Montagna, Robert W. Mysłajek, Marco T. Neiber, Violaine Nicolas, Marta Novo, Petar Ozretić, Ferran Palero, Lucian Pârvulescu, Marta Pascual, Octávio S. Paulo, Martina Pavlek, Cinta Pegueroles, Loïc Pellissier, Graziano Pesole, Craig R. Primmer, Ana Riesgo, Lukas Rüber, Diego Rubolini, Daniele Salvi, Ole Seehausen, Matthias Seidel, Bruno Studer, Spyros Theodoridis, Marco Thines, Lara Urban, Anti Vasemägi, Adriana Vella, Noel Vella, Sonja C. Vernes, Cristiano Vernesi, David R. Vieites, Christophe Pampoulie, Gert Wörheide, Yannick Wurm, Gabrielle Zammit,
The availability of public genomic resources can greatly assist biodiversity assessment, conservation, and restoration efforts by providing evidence for scientifically informed management decisions. Here we survey the main approaches and applications in biodiversity and conservation genomics, considering practical factors, such as cost, time, prerequisite skills, and current shortcomings of applications. Most approaches perform best in combination with reference genomes from the target species or ...
Tópico(s): Molecular Biology Techniques and Applications
2023 - Elsevier BV | Trends in Genetics
Micaela Berni, Alice Maria Brancato, Camilla Torriani, Valentina Bina, Salvatore Annunziata, Elena Cornella, Michelangelo Trucchi, Eugenio Jannelli, Mario Mosconi, Giulia Gastaldi, Laura Caliogna, Federico Alberto Grassi, Gianluigi Pasta,
Low-level laser therapy (LLLT) is a treatment that is increasingly used in orthopedics practices. In vivo and in vitro studies have shown that low-level laser therapy (LLLT) promotes angiogenesis, fracture healing and osteogenic differentiation of stem cells. However, the underlying mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation and frequency of LLLT can influence the cellular mechanisms. Moreover, the effects of LLLT are different ...
Tópico(s): Laser Applications in Dentistry and Medicine
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Giulio Formenti, Linelle Abueg, Angelo Brajuka, Nadolina Brajuka, Cristóbal Gallardo Alba, Alice Maria Giani, Olivier Fédrigo, Erich D. Jarvis,
Abstract Motivation With the current pace at which reference genomes are being produced, the availability of tools that can reliably and efficiently generate genome assembly summary statistics has become critical. Additionally, with the emergence of new algorithms and data types, tools that can improve the quality of existing assemblies through automated and manual curation are required. Results We sought to address both these needs by developing gfastats, as part of the Vertebrate Genomes Project ( ...
Tópico(s): Chromosomal and Genetic Variations
2022 - Oxford University Press | Bioinformatics
Giulio Formenti, Kathrin Theißinger, Carlos Fernandes, Iliana Bista, Aureliano Bombarely, Christoph Bleidorn, Claúdio Ciofi, Angelica Crottini, José A. Godoy, Jacob Höglund, Joanna Malukiewicz, Alice Mouton, Rebekah A. Oomen, Sadye Paez, Per J. Palsbøll, Christophe Pampoulie, María José Ruiz‐López, Hannes Svardal, Constantina Theofanopoulou, Jan de Vries, Ann‐Marie Waldvogel, Guojie Zhang, Camila J. Mazzoni, Erich D. Jarvis, Miklós Bálint, Giulio Formenti, Kathrin Theißinger, Carlos Fernandes, Iliana Bista, Aureliano Bombarely, Christoph Bleidorn, Fedor Čiampor, Claúdio Ciofi, Angelica Crottini, José A. Godoy, Jacob Höglund, Joanna Malukiewicz, Alice Mouton, Rebekah A. Oomen, Sadye Paez, Per J. Palsbøll, Christophe Pampoulie, María José Ruiz‐López, Hannes Svardal, Constantina Theofanopoulou, Jan de Vries, Ann‐Marie Waldvogel, Goujie Zhang, Camila J. Mazzoni, Erich D. Jarvis, Miklós Bálint, Sargis A. Aghayan, Tyler Alioto, Isabel Almudí, Nadir Álvarez, Paulo C. Alves, Isabel R. Amorim, Agostinho Antunes, Paula Arribas, Petr Baldrián, Paul R. Berg, Giorgio Bertorelle, Astrid Böhne, Andrea Bonisoli‐Alquati, Ljudevit Luka Boštjančić, Bastien Boussau, Catherine Breton, Elena Bužan, Paula F. Campos, Carlos Carreras, L. Filipe C. Castro, Luis J. Chueca, Elena Conti, Robert Cook‐Deegan, Daniel Croll, Mónica V. Cunha, Frédéric Delsuc, Alice B. Dennis, Dimitar Dimitrov, Rui Faria, Adrien Favre, Olivier Fédrigo, Rosa Fernández, Gentile Francesco Ficetola, Jean‐François Flot, Toni Gabaldón, D. Agius, Guido Roberto Gallo, Alice Maria Giani, M. Thomas P. Gilbert, Tine Grebenc, Katerina Guschanski, Romain Guyot, Bernhard Hausdorf, Oliver Hawlitschek, Peter D. Heintzman, Berthold Heinze, Michael Hiller, Martin Husemann, Alessio Iannucci, Iker Irisarri, Kjetill S. Jakobsen, Sissel Jentoft, Peter Klinga, Agnieszka Kloch, Claudius F. Kratochwil, Henrik Kusche, Kara K S Layton, Jennifer A. Leonard, Emmanuelle Lerat, Gianni Liti, Tereza Manousaki, Tomàs Marquès‐Bonet, Pável Matos‐Maraví, Michael Matschiner, Florian Maumus, Ann M. Mc Cartney, Shai Meiri, José Melo‐Ferreira, Ximo Mengual, Michael T. Monaghan, Matteo Montagna, Robert W. Mysłajek, Marco T. Neiber, Violaine Nicolas, Marta Novo, Petar Ozretić, Ferran Palero, Lucian Pârvulescu, Marta Pascual, Octávio S. Paulo, Martina Pavlek, Cinta Pegueroles, Loïc Pellissier, Graziano Pesole, Craig R. Primmer, Ana Riesgo, Lukas Rüber, Diego Rubolini, Daniele Salvi, Ole Seehausen, Matthias Seidel, Simona Secomandi, Bruno Studer, Spyros Theodoridis, Marco Thines, Lara Urban, Anti Vasemägi, Adriana Vella, Noel Vella, Sonja C. Vernes, Cristiano Vernesi, David R. Vieites, Robert M. Waterhouse, Christophe Pampoulie, Gert Wörheide, Yannick Wurm, Gabrielle Zammit,
Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics.
Tópico(s): Genetic diversity and population structure
2022 - Elsevier BV | Trends in Ecology & Evolution
Produção Nacional
Revisado por pares
Estéfenson Marques Morais, Alex Silva, Francisco Wderson Araújo de Sousa, Izabelle Maria Barboza de Azevedo, Helane França Silva, Alice Maria Gonçalves Santos, José Evando Aguiar Beserra, Caroline Pais de Carvalho, Marcos N. Eberlin, Andréia M. Porcari, Francisca Diana da Silva Araújo,
The indiscriminate use of chemical pesticides increasingly harms the health of living beings and the environment. Thus, biological control carried out by microorganisms has gained prominence, since it consists of an environmentally friendly alternative to the use of pesticides for controlling plant diseases. Herein, we evaluated the potential role of endophytic Trichoderma strains isolated from forest species of the Cerrado-Caatinga ecotone as biological control agents of crop pathogenic fungi. ...
Tópico(s): Plant Pathogens and Fungal Diseases
2022 - Public Library of Science | PLoS ONE
Alice Maria Almeida, Maria João Martins, Manuel L. Campagnolo, Paulo Fernandez, Teresa Albuquerque, Saki Gerassis, José Carlos Gonçalves, Maria Margarida Ribeiro,
Abstract Climate change is a challenge for forests in the coming decades, with a major impact on species adaptation and distribution. The Mediterranean Basin is one of the most vulnerable hotspots for biodiversity conservation under climate change in the world. This research aimed at studying a Mediterranean species well adapted to the region: the Arbutus unedo L. (strawberry tree). The MaxEnt, a presence-only species-distribution software, was used to model A. unedo’s environmental suitability. ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2022 - Nature Portfolio | Scientific Reports
Laura Caliogna, Viviana Guerrieri, Salvatore Annunziata, Valentina Bina, Alice Maria Brancato, Alberto Castelli, Eugenio Jannelli, Alessandro Ivone, Federico Alberto Grassi, Mario Mosconi, Gianluigi Pasta,
Ehlers-Danlos syndromes (EDS) are an inherited heterogeneous group of connective tissue disorders characterized by an abnormal collagen synthesis affecting skin, ligaments, joints, blood vessels, and other organs. It is one of the oldest known causes of bruising and bleeding, and it was described first by Hippocrates in 400 BC. In the last years, multiple gene variants involved in the pathogenesis of specific EDS subtypes have been identified; moreover, new clinical diagnostic criteria have been ...
Tópico(s): Dupuytren's Contracture and Treatments
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Bruno Henrique Tondato Arantes, Victor Hugo Morães, Alaerson Maia Geraldine, Tavvs Micael Alves, Alice Maria Albert, Gabriel Jesus da Silva, Gustavo Castoldi,
ABSTRACT: Soybean is one of the main crop species grown in the world. However, there is a decline in productivity due to the various types of stress, including the nematodes Heterodera glycines and Pratylenchus brachyurus. The objectives were to determine the best spectral band for detecting H. glycines and P. brachyurus at the beginning of flowering (R1). Soil and root sampling was conducted at nine sampling sites in each of the five nematode-infested regions, totaling 45 sampling points. Flights ...
Tópico(s): Remote Sensing in Agriculture
2021 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Revisado por pares
Márcia Machado Marinho, Francisco Wagner Queiroz Almeida-Neto, Emanuelle Machado Marinho, Leonardo P. da Silva, Ramon Róseo Paula Pessoa Bezerra de Menezes, Ricardo P. dos Santos, Emmanuel Silva Marinho, Pedro de Lima‐Neto, Alice Maria Costa Martins,
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi, with approximately 6-7 million people infected worldwide, becoming a public health problem in tropical countries, thus generating an increasing demand for the development of more effective drugs, due to the low efficiency of the existing drugs. Aiming at the development of a new antichagasic pharmacological tool, the density functional theory was used to calculate the reactivity descriptors of amentoflavone, ...
Tópico(s): Bioactive Compounds and Antitumor Agents
2021 - Elsevier BV | Heliyon
Ilaria Ferrarotti, Stefania Ottaviani, Alice Maria Balderacchi, Valentina Barzon, Annalisa De Silvestri, Davide Piloni, Francesca Mariani, Angelo Guido Corsico,
The clinical manifestations of COVID-19 are heterogeneous: 46.4% of patients admitted into hospital reported to have at least one comorbidity. Comorbidities such as COPD, diabetes, hypertension and malignancy predispose patients with Covid-19 to adverse clinical outcomes. Alpha 1-antitrypsin deficiency (AATD) is a genetic disorder caused by pathological mutation(s) in the SERPINA1 gene resulting in an imbalance in proteinase activity which may lead to premature emphysema and COPD.Our aim was to investigate ...
Tópico(s): Cell death mechanisms and regulation
2021 - Elsevier BV | Respiratory Medicine
Laura Caliogna, Marta Medetti, Valentina Bina, Alice Maria Brancato, Alberto Castelli, Eugenio Jannelli, Alessandro Ivone, Giulia Gastaldi, Salvatore Annunziata, Mario Mosconi, Gianluigi Pasta,
In this article, we provide an extensive review of the recent literature of the signaling pathways modulated by Pulsed Electromagnetic Fields (PEMFs) and PEMFs clinical application. A review of the literature was performed on two medical electronic databases (PubMed and Embase) from 3 to 5 March 2021. Three authors performed the evaluation of the studies and the data extraction. All studies for this review were selected following these inclusion criteria: studies written in English, studies available ...
Tópico(s): Microbial Inactivation Methods
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Iraneide Nascimento dos Santos, Marília Lopes Pernambuco, Alice Maria Barbosa da Silva, Guilherme de Andrade Ruela, Adriana Sarmento de Oliveira,
Telework has been an alternative for companies to remain active in the market during the coronavirus disease 2019 (COVID 19) pandemic.To analyze the mains scientific evidence on the association between musculoskeletal pain and home office work during the COVID 19 pandemic.This is an integrative review guided by the following question: can workers present musculoskeletal pain due to home office work during the COVID 19 pandemic? The searches were conducted on the bases de dados MEDLINE (via PubMed), ...
Tópico(s): Ergonomics and Musculoskeletal Disorders
2021 - | Revista Brasileira de Medicina do Trabalho
Alice Maria Balderacchi, Valentina Barzon, Stefania Ottaviani, Alessandra Corino, Michele Zorzetto, Marion Wencker, Angelo Guido Corsico, Ilaria Ferrarotti,
Abstract Objectives Alpha1-antitrypsin deficiency (AATD) is an inherited condition that predisposes individuals to an increased risk of developing lung and liver disease. Even though AATD is one of the most widespread inherited diseases in Caucasian populations, only a minority of affected individuals has been detected. Whereas methods have been validated for AATD testing, there is no universally-established algorithm for the detection and diagnosis of the disorder. In order to compare different ...
Tópico(s): Enzyme Production and Characterization
2021 - De Gruyter | Clinical Chemistry and Laboratory Medicine (CCLM)
Produção Nacional
Revisado por pares
Renata Paoli Santos, Fernando N. Souza, Ana Cláudia Dumont Oliveira, Antônio Francisco de Souza Filho, Juliana Aizawa, Luisa Zanolli Moreno, Adriano França da Cunha, Adriana Cortéz, Alice Maria Melville Paiva Della Libera, Marcos Bryan Heinemann, M.M.O.P. Cerqueira,
In the present study, we aimed to determine the antimicrobial resistance and molecular typing of Staphylococcus aureus recovered from transient and persistent intramammary infections and nares/muzzles in dairy cows. We investigated the antimicrobial resistance of 189 S. aureus strains using a broad antimicrobial susceptibility profile. Furthermore, 107 S. aureus isolates were strain-typed using staphylococcal protein-A (spa) typing. A large proportion of strains exhibited multidrug resistance to ...
Tópico(s): Antimicrobial Resistance in Staphylococcus
2020 - Multidisciplinary Digital Publishing Institute | Animals
Produção Nacional
Revisado por pares
Janice Pacheco Dias Padilha, Carolina Serpa Brasil, Alice Maria Luderitz Hoefel, Pablo Brea Winckler, Karina Carvalho Donis, Ana Carolina Brusius‐Facchin, Jonas Alex Morales Saute,
Abstract Diagnostic yield of genetic studies for Charcot‐Marie‐Tooth disease (CMT) is little known, with a lack of epidemiological data to build better diagnostic strategies outside the United States and Europe. We aimed to evaluate the performance of two molecular diagnostic strategies for patients with CMT, and to characterize epidemiological findings of these conditions in southern Brazil. We performed a single‐center cross‐sectional study, in which 94 patients (55 families) with CMT suspicion ...
Tópico(s): Genetic Neurodegenerative Diseases
2020 - Wiley | Clinical Genetics
Produção Nacional
Revisado por pares
Danilo Rodrigues, Alice Maria Correia Pequeno, Antônio Germane Alves Pinto, Cleide Carneiro, Maria de Fátima Antero Sousa Machado, Antônio Germano Magalhães, Francisca Diana da Silva Negreiros,
ABSTRACT Objective: To analyze the understanding of the professionals working on the Family Health Support by about permanent education and matrix support in the daily routine of primary health care. Methods: Descriptive research with a qualitative approach. Data were collected through semi-structured interviews with the participation of 19 professionals from different backgrounds. The results were organized based on Thematic Content Analysis. Results: Thematic categories emerged from the analysis: ...
Tópico(s): Male Reproductive Health Studies
2020 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Produção Nacional
Revisado por pares
Polianna Lemos Moura Moreira Albuquerque, José Hícaro Hellano Gonçalves Lima Paiva, Alice Maria Costa Martins, Gdayllon Cavalcante Meneses, Geraldo Bezerra da Silva, Nicholas A. Buckley, Elizabeth De Francesco Daher,
Bothrops are one of the most common medically important snakes found in Latin America. Its venom is predominantly hemotoxic and proteolytic, which means that local lesion (edema and redness) and hemorrhagic symptoms are recurrent in envenoming by this snake. Although hemorrhage is usually the major cause of death, snakebite-related acute kidney injury is another potentially fatal clinical complication that may lead to chronic kidney disease. The present review highlights the main studies on Bothrops ...
Tópico(s): Bioactive Natural Diterpenoids Research
2020 - BioMed Central | The Journal of venomous animals and toxins including tropical diseases
Produção Nacional
Revisado por pares
Marília Lopes Monteiro, Dânya Bandeira Lima, Ramon Róseo Paula Pessoa Bezerra de Menezes, Tiago Lima Sampaio, Brenna Pinheiro Silva, João Victor Serra Nunes, Mariana Maciel Cavalcanti, Jean-Étienne Morlighem, Alice Maria Costa Martins,
Trypanosoma cruzi, the etiological agent of Chagas disease, is responsible for the infection of millions of people worldwide and it is a public health problem, without an effective cure. Four fragments with antimicrobial potential from the hemocyanin of Penaeus monodon shrimp were identified using a computer software AMPA. The present study aimed to evaluate the antichagasic effect of these four peptides (Hmc364-382, Hmc666-678, Hmc185-197 and Hmc476-498). The peptides were tested against the epimastigote, ...
Tópico(s): Insect symbiosis and bacterial influences
2020 - Elsevier BV | Experimental Parasitology
Produção Nacional
Revisado por pares
Bárbara Maria Lopes da Silva Brandão, Alice Maria Barbosa da Silva, Rafaella Queiroga Souto, Fábia Alexandra Pottes Alves, Gleicy Karine Nascimento de Araújo-Monteiro, Viviane Cristina Fonseca da Silva Jardim, Hulda Vale de Araújo,
ABSTRACT Objective: to assess cognitive functions and their association with quality of life among elderly people enrolled in a Family Health Unit (FHU) of Primary Health Care in Recife-PE. Methods: a quantitative, descriptive, cross-sectional study in which elderly aged 60 years and over were studied. Results: 76.7% of the elderly were women and the age group was less than or equal to 70 years. 68.6% had cognitive impairment, and in the quality of life assessment it was found that the social participation ...
Tópico(s): Dementia and Cognitive Impairment Research
2020 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Produção Nacional
Revisado por pares
Katielle Albuquerque Freire, Marcelo D. T. Torres, Dânya Bandeira Lima, Marília Lopes Monteiro, Ramon Róseo Paula Pessoa Bezerra de Menezes, Alice Maria Costa Martins, Vani Xavier Oliveira,
Chagas disease is caused by Trypanosoma cruzi and affects approximately 10 million people a year worldwide. The only two treatment options, benznidazole and nifurtimox, have low efficacy and high toxicity towards human cells. Mastoporan peptide (MP) a small cationic AMP from the venom of the wasp Polybia paulista has been reported as a potent trypanocidal agent. Thus, we evaluated the antichagasic effect of another AMP from the venom of the same wasp Polybia paulista, polybia-CP (ILGTILGLLSKL-NH2), ...
Tópico(s): Trypanosoma species research and implications
2020 - Elsevier BV | Toxicon
Produção Nacional
Revisado por pares
Adriano França da Cunha, Hélida Monteiro de Andrade, Fernando N. Souza, L.C. Fialho, Dalila Lapinha Silva Oliveira Rosa, Eduardo Milton Ramos-Sanchez, Magnus Gidlund, Hiro Goto, Maria Aparecida Vasconcelos Paiva Brito, Alessandro de Sá Guimarães, Andrey Pereira Lage, Luiza Campos Reis, Alice Maria Melville Paiva Della Libera, Marcos Bryan Heinemann, M.M.O.P. Cerqueira,
ABSTRACT Staphylococcus aureus is one of the pathogens most frequently isolated from cases of mastitis worldwide. To decrease the effect of S. aureus mastitis in dairy farming, alternative strategies for controlling mastitis are needed that depend on a better knowledge of cow-to-cow variations in S. aureus antibody production. The present study sought to explore the diversity of S. aureus antibodies produced by dairy cows with a distinct mastitis history and vaccinated with a polyvalent mastitis vaccine. ...
Tópico(s): Microbial infections and disease research
2020 - Elsevier BV | Journal of Dairy Science
Stefania Ottaviani, Valentina Barzon, Amaya Buxens, Marina Gorrini, Amaia Larruskain, Rachid El Hamss, Alice Maria Balderacchi, Angelo Guido Corsico, Ilaria Ferrarotti,
Abstract Background Alpha1‐antitrypsin deficiency (AATD) is an under‐diagnosed hereditary disorder characterized by reduced serum levels of alpha1‐antitrypsin (AAT) and increased risk to develop lung and liver diseases at an early age. AAT is encoded by the highly polymorphic SERPINA1 gene. The most common deficiency alleles are S and Z, but more than 150 rare variants lead to low levels of the protein. To identify these pathological allelic variants, sequencing is required. Since traditional sequencing ...
Tópico(s): Peptidase Inhibition and Analysis
2020 - Wiley | Journal of Clinical Laboratory Analysis
Produção Nacional
Revisado por pares
Fernando N. Souza, Maiara Garcia Blagitz, Camila Freitas Batista, Paulo Vitor Takano, Ronaldo Gomes Gargano, S.A. Diniz, M.X. Silva, José Augusto Ferronatto, Kamila Reis Santos, Marcos Bryan Heinemann, Sarne De Vliegher, Alice Maria Melville Paiva Della Libera,
We analyzed a large number of immune response parameters from quarter milk samples with distinct bacteriological and quarter somatic cell count (qSCC) statuses. Furthermore, we sought to explore and identify displayed immune response patterns in milk samples from mammary glands with nonspecific mastitis. Thus, 92 quarter milk samples from 28 cows were stratified into 4 groups, as follows: (1) 49 culture-negative control quarters with a low qSCC ( 2 × 105 cells/mL; so-called quarters with nonspecific mastitis) ...
Tópico(s): Animal Diversity and Health Studies
2020 - Elsevier BV | Journal of Dairy Science
Produção Nacional
Revisado por pares
Gdayllon Cavalcante Meneses, Geraldo Bezerra da Silva, Paulo Pacelli Bezerra Filizola Tôrres, Valeska Queiroz de Castro, Renata Lima Lopes, Alice Maria Costa Martins, Elizabeth De Francesco Daher,
Tropical diseases are mainly found in the tropical regions of Asia, Africa and Latin America. They are a major Public Health problem in these regions, most of them are considered neglected diseases and remain as important contributors to the development of AKI (Acute Kidney Injury), which is associated with increased patients' morbidity and mortality. In most countries, kidney disease associated to tropical diseases is attended at health services with poor infrastructure and inadequate preventive ...
Tópico(s): Mosquito-borne diseases and control
2020 - UNIVERSIDADE DE SÃO PAULO | Revista do Instituto de Medicina Tropical de São Paulo