Produção Nacional
Revisado por pares
Priscila Lima Sequetto, Reggiani Vilela Gonçalves, Aloísio Silva Pinto, M. G. A. Oliveira, Izabel R.S.C. Maldonado, Tânia Toledo de Oliveira, Rômulo Dias Novaes,
Abstract By using an experimental model of dexamethasone-induced osteoporosis we investigated the effects of different therapeutic schemes combining sodium alendronate (SA) and simvastatin on bone mineral and protein composition, microstructural and mechanical remodeling. Wistar rats were randomized into eight groups: G1: non-osteoporotic; G2: osteoporotic; G3, G4, and G5: osteoporotic+SA (0.2, 0.4, and 0.8 mg/kg, respectively); G6, G7, and G8: osteoporotic+SA (0.2, 0.4, and 0.8 mg/kg, respectively)+ ...
Tópico(s): Bone health and treatments
2017 - Oxford University Press | Microscopy and Microanalysis
Mojgan Ahmadzadeh, Aloísio Felipe-Silva, Bianca Heemskerk, Daniel J. Powell, John R. Wunderlich, Maria J. Merino, Steven A. Rosenberg,
Abstract Regulatory T (Treg) cells are often found in human tumors; however, their functional characteristics have been difficult to evaluate due to low cell numbers and the inability to adequately distinguish between activated and Treg cell populations. Using a novel approach, we examined the intracellular cytokine production capacity of tumor-infiltrating T cells in the single-cell suspensions of enzymatically digested tumors to differentiate Treg cells from effector T cells. Similar to Treg cells ...
Tópico(s): Immunotherapy and Immune Responses
2008 - Elsevier BV | Blood
Daniel J. Powell, Aloísio Felipe-Silva, Maria J. Merino, Mojgan Ahmadzadeh, Tamika Allen, Catherine Lévy, Donald E. White, Sharon Mavroukakis, Robert J. Kreitman, Steven A. Rosenberg, Ira Pastan,
Abstract CD25+CD4+ T regulatory (Treg) cells regulate peripheral self tolerance and possess the ability to suppress antitumor responses, which may in part explain the poor clinical response of cancer patients undergoing active immunization protocols. We have previously shown that in vitro incubation of human PBMC with LMB-2, a CD25-directed immunotoxin, significantly reduced CD25+FOXP3+CD4+ Treg cells without impairing the function of the remaining lymphocytes. In the current study, eight patients ...
Tópico(s): T-cell and B-cell Immunology
2007 - American Association of Immunologists | The Journal of Immunology
Produção Nacional
Revisado por pares
Joanna D.C.C. Lima, Estefanía Simoes, Gabriela Salim de Castro, Mychel Morais, Emídio Marques de Matos‐Neto, Michele Joana Alves, Nelson Inácio Pinto Neto, Raquel Galvão Figuerêdo, Telma M.T. Zorn, Aloísio Felipe-Silva, Flávio Tokeshi, José Pinhata Otoch, Paulo Alcantara, Fernanda Janku Cabral, Emer S. Ferro, Alessandro Laviano, Marília Seelaender,
Abstract Background Cachexia is a paraneoplastic syndrome related with poor prognosis. The tumour micro‐environment contributes to systemic inflammation and increased oxidative stress as well as to fibrosis. The aim of the present study was to characterise the inflammatory circulating factors and tumour micro‐environment profile, as potentially contributing to tumour fibrosis in cachectic cancer patients. Methods 74 patients (weight stable cancer n = 31; cachectic cancer n = 43) diagnosed with colorectal ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2019 - Springer Science+Business Media | Journal of Cachexia Sarcopenia and Muscle
Produção Nacional
Revisado por pares
Cinthya dos Santos Cirqueira, Aloísio Felipe-Silva, Alda Wakamatsu, Lidiane Vieira Marins, Eziel Cavalcanti Rocha, Evandro Sobroza de Mello, Venâncio Avancini Ferreira Alves,
Multidrug resistance-associated protein 2 (MRP2) is a multi-specific organic anion transporter predominantly expressed in the canalicular membrane of hepatocytes, epithelial cells from gallbladder and apical membranes of proximal tubular kidney epithelium whereas multidrug resistance-associated protein 3 (MRP3) is present in the basolateral membrane of hepatocytes and cholangiocytes. This study aims to detect the expression of these transporters in hepatocellular carcinoma (HCC) and in cholangiocarcinoma ( ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2018 - Springer Science+Business Media | Pathology & Oncology Research
Produção Nacional
Revisado por pares
Mariana Maschietto, Laura Caroline Bastos, Ana Carolina Tahira, Elen Pereira Bastos, Verônica Euclydes, Alexandra Brentani, Günther Fink, Angélica de Baumont, Aloísio Felipe-Silva, Rossana Pulcineli Vieira Francisco, Gisele Rodrigues Gouveia, Sandra Josefina Ferraz Ellero Grisi, Ana María Escobar, Carlos Alberto Moreira‐Filho, Guilherme V. Polanczyk, Eurípedes C. Miguel, Helena Brentani,
Abstract Sex differences in the prevalence of psychiatric disorders are well documented, with exposure to stress during gestation differentially impacting females and males. We explored sex-specific DNA methylation in the cord blood of 39 females and 32 males born at term and with appropriate weight at birth regarding their potential connection to psychiatric outcomes. Mothers were interviewed to gather information about environmental factors (gestational exposure) that could interfere with the methylation ...
Tópico(s): Adolescent and Pediatric Healthcare
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Fernando Peixoto Ferraz de Campos, Vitor Sérgio Kawabata, Márcio Sommer Bittencourt, Silvana Maria Lovisolo, Aloísio Felipe-Silva, Ana Paula Silva de Lemos,
The incidence of severe complications of the Neisseria gonorrhoeae infection has presented variations over recent decades since the advent of penicillin. Gonococcal endocarditis (GE) still remains an ever-present threat afflicting the society's poor and sexually active young population. This entity frequently requires surgical intervention and usually exhibits a poor outcome. The interval between the onset of symptoms and the diagnosis does not usually exceed 4 weeks. One of the characteristics of ...
Tópico(s): Streptococcal Infections and Treatments
2016 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Revisado por pares
Gabriel Núncio Benevides, German Alcoba Salgado, Cristiane Rúbia Ferreira, Aloísio Felipe-Silva, Alfredo Elias Gilio,
The symptoms of a previously healthy 14-year-old female with an initial history of tooth pain and swelling of the left maxillary evolved to a progressive headache and altered neurological findings characterized by auditory hallucinations, sleep disturbances, and aggressiveness. She was brought to the emergency department after 21 days of the initial symptoms. An initial computed tomography (CT) scan showed frontal subdural empyema with bone erosion. The symptoms continued to evolve to brain herniation ...
Tópico(s): Infectious Diseases and Tuberculosis
2015 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Venâncio Avancini Ferreira Alves, Céline Pinheiro, Filipa Morais-Santos, Aloísio Felipe-Silva, Adhemar Longatto‐Filho, Fátima Baltazar,
AIM:To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma (HCC). METHODS: From a total of 5836 autopsies performed at the Pathology Department -University of Sao Paulo School of Medicine Hospital -from 2003 to 2009, 188 presented primary liver tumors.Immunohistochemical reactivity for monocarboxylate transporters (MCTs)-1, 2 and4, CD147 andglucose transporter-1 (GLUT1) was assessed in necropsies from 80 cases of HCC.Data ...
Tópico(s): Metabolism, Diabetes, and Cancer
2014 - Baishideng Publishing Group | World Journal of Gastroenterology
Produção Nacional
Revisado por pares
Gilney Figueira Zebende, Priscila Andrade da Silva, Aloísio Machado da Silva Filho,
We study in this paper the cross-correlation between self-affine time series of real variables recorded simultaneously in cases of taxi accidents. For this purpose, we apply the DCCA method and show that the cross-correlation can be divided into three distinct groups, if we look for the detrended covariance function, i.e., long-range cross-correlations, short-range cross-correlations and no cross-correlations. Finally, it will be seen that the detrended covariance function is robust, if compared ...
Tópico(s): Financial Risk and Volatility Modeling
2011 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Leonardo Ramos Paes de Lima, Tânia Toledo de Oliveira, Tânus Jorge Nagem, Aloisio da Silva PINTO, Paulo César Stringheta, Adelson Luiz Araújo Tinôco, José Francisco da Silva,
Os flavonóides apresentam diversas atividades biológicas (antioxidantes, antiinflamatórios, anticancerígenos, dentre outras) e estreitas correlações entre o consumo de alimentos ricos em flavonóides e doenças cardíacas.Pesquisas mostram que os flavonóides 7-glicosilapigenina, 7-bissulfato-apigenina, 7-glicosil-luteolina, 7-bissulfato-luteolina e os corantes bixina e norbixina foram isolados e identificadas suas estruturas de sementes de urucum.O objetivo deste estudo foi testar, isoladamente bixina, ...
Tópico(s): Bee Products Chemical Analysis
2001 - UNIVERSIDADE DE SÃO PAULO | Brazilian Journal of Veterinary Research and Animal Science
Produção Nacional
Revisado por pares
Kelly Fabiane Santos Ricardo, Tânia Toledo de Oliveira, Tânus Jorge Nagem, Aloísio da Silva Pinto, Maria Goreti Almeida Oliveira, José Francisco Soares,
Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. ...
Tópico(s): Natural Antidiabetic Agents Studies
2001 - Instituto de Tecnologia do Paraná (Tecpar) | Brazilian Archives of Biology and Technology
Produção Nacional
Revisado por pares
Vivian Helena Iida, Thiago Junqueira A. da Silva, Aloísio Souza F. da Silva, Luiz Fernando Ferraz da Silva, Venâncio Avancini Ferreira Alves,
INTRODUÇÃO: A cirrose hepática é muito prevalente em nosso meio, cursando freqüentemente com complicações como insuficiência e carcinoma hepatocelulares e hipertensão portal. OBJETIVOS: Analisar os aspectos clínicos e morfológicos das cirroses, relacionando-os com os principais padrões histológicos e suas complicações. MATERIAL E MÉTODO: Entre 35 fígados cirróticos provenientes de necropsias realizadas no Serviço de Verificação de Óbitos da Capital (SVOC-SP), estudados em cortes seqüenciais a cada ...
Tópico(s): Liver Disease Diagnosis and Treatment
2005 - Sociedade Brasileira de Patologia Clínica | Jornal Brasileiro de Patologia e Medicina Laboratorial
Produção Nacional
Revisado por pares
Marcus Fernandes da Silva, Éder Johnson de Area Leão Pereira, Aloísio Machado da Silva Filho, Arleys Pereira Nunes de Castro, José García Vivas Miranda, Gilney Figueira Zebende,
Tópico(s): Monetary Policy and Economic Impact
2016 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Marcus Fernandes da Silva, Éder Johnson de Area Leão Pereira, Aloísio Machado da Silva Filho, Arleys Pereira Nunes de Castro, José García Vivas Miranda, Gilney Figueira Zebende,
The objective of this paper is to demonstrate the influence of the blue-chips companies in the stock market. In this, we apply the detrended cross-correlation coefficient ρDCCA at the São Paulo stock market (Ibovespa, Brazil). Initially we found that there is a positive cross-correlation between these companies and the index. Afterwards, we show that the cross-correlation coefficient value depends on the time scale and the specific company (blue-chips). Thus, this type of analysis lets to infer what ...
Tópico(s): Market Dynamics and Volatility
2015 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Silvana Sandri, Luis Roberto Masao Watanabe, Érica Aparecida de Oliveira, Fernanda Faião‐Flores, Silene Migliorini, Manoela Tiago, Aloísio Felipe-Silva, Vinícius de Lima Vazquez, Paola da Costa Souza, Márcia Edilaine Lopes Consolaro, Ana Čampa, Silvya Stuchi Maria‐Engler,
Indoleamine 2,3-dioxygenase (IDO) is associated with the progression of many types of tumors, including melanoma. However, there is limited information about IDO modulation on tumor cell itself and the effect of BRAF inhibitor (BRAFi) treatment and resistance. Herein, IDO expression was analyzed in different stages of melanoma development and progression linked to BRAFi resistance. IDO expression was increased in primary and metastatic melanomas from patients' biopsies, especially in the immune cells ...
Tópico(s): Cancer, Stress, Anesthesia, and Immune Response
2020 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Fernanda Pessorrusso, Aloísio Felipe-Silva, Carlos Eduardo Jacob, Marcus Fernando Kodama Pertille Ramos, V. Ferreira, Evandro Sobroza de Mello, Bruno Zilberstein, Ulysses Ribeiro, Fauze Maluf‐Filho,
Tópico(s): Helicobacter pylori-related gastroenterology studies
2018 - Elsevier BV | Gastrointestinal Endoscopy
Produção Nacional
Revisado por pares
Vinícius Costa Almeida, José Marcelo Soriano Viana, Henrique Morais DeOliveira, Leonardo Alves Risso, Aloísio Fernando Silva Ribeiro, Rodrigo Oliveira DeLima,
Abstract Modern maize hybrid breeding is also focused on increasing nitrogen use efficiency ( NUE ) for grain production. The objectives of this study were to assess popcorn inbred lines for NUE , assess its genetic diversity for NUE and related traits, and investigate the relationship between vegetative and adult traits with NUE , under contrasting N levels. Nineteen inbreds were assessed for NUE and related traits under two contrasting N levels in a 2‐year experiment, using complete blocks with three ...
Tópico(s): Genetics and Plant Breeding
2018 - Wiley | Plant Breeding
Produção Nacional
Revisado por pares
Lívia Barreira Cavalcante, Aloísio Felipe-Silva, Fernando Peixoto Ferraz de Campos, João Augusto dos Santos Martinês,
Lung adenocarcinomas with a mixture of tubular or papillary pattern, sheet-like or trabecular architecture, eosinophilic cytoplasm with centrally located nuclei and alpha-fetoprotein-producing cells have been described as hepatoid adenocarcinomas. Hepatoid adenocarcinomas are mainly found in the stomach but rare cases in other organs have been described. Immunostaining for alpha-fetoprotein (AFP), hepatocyte paraffin 1 (HepPar-1) and thyroid transcription factor-1 (TTF-1) helps in the diagnostic workup. ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2013 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Revisado por pares
Everaldo Freitas Guedes, Aloísio Machado da Silva Filho, Gilney Figueira Zebende,
In this paper we implemented the detrended multiple cross-correlation coefficient with sliding windows approach in order to measure multiple cross-correlation between time series as a function of time scale n, and a sliding time τ. Faced with several non-stationary time series, a fixed size window will be defined by w, and the coefficients DMCx2 are calculated for different time scales (4≤n≤w4) and time τ. Following this methodology, it was possible to set up a DMCx2 cross-correlation color map for ...
Tópico(s): Chaos control and synchronization
2021 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Aloísio Machado da Silva Filho, Gilney Figueira Zebende, Arleys Pereira Nunes de Castro, Everaldo Freitas Guedes,
In this paper, we proposed a statistical test for the Multiple Detrended Correlation Coefficient DMCx2. The DMCx2 is a measure of total association between the dependent variable, Y, with other p independent variables, X all with the same length N. DMCx2 is based on the generalization of the ρ(Xi,Xj) cross-correlation coefficient. With this methodology, it is possible to evaluate the statistical significance of DMCx2 for different levels confidence. Findings on this research show that rejection ...
Tópico(s): Financial Risk and Volatility Modeling
2020 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Everaldo Freitas Guedes, Adriana Brito, Florêncio Mendes Oliveira Filho, B.F. Fernandez, Arleys Pereira Nunes de Castro, Aloísio Machado da Silva Filho, Gilney Figueira Zebende,
In this paper we propose a new statistical test for ΔρDCCA, Detrended Cross-Correlation Coefficient Difference, a tool to measure contagion/interdependence effect in time series of size N at different time scale n. For this proposition we analyzed simulated and real time series. The results showed that the statistical significance of ΔρDCCA depends on the size N and the time scale n, and we can define a critical value for this dependency in 90%, 95%, and 99% of confidence level, as will be shown ...
Tópico(s): Financial Risk and Volatility Modeling
2018 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Everaldo Freitas Guedes, Adriana Brito, Florêncio Mendes Oliveira Filho, B.F. Fernandez, Arleys Pereira Nunes de Castro, Aloísio Machado da Silva Filho, Gilney Figueira Zebende,
In this paper the algorithm for ΔρDCCA statistical test (Guedes et al., 2018) [1] is presented. Our test begins with the simulation of four time series pairs, by an ARFIMA process. These time series has N=250 , 500, 1000, and 2000 points, see Guedes et al. (2018) [1]. The probability distribution function (PDF) is made available for all 10,000 samples, that start from the original time series, in supplementary material.
Tópico(s): Time Series Analysis and Forecasting
2018 - Elsevier BV | Data in Brief
Produção Nacional
Revisado por pares
Gilney Figueira Zebende, Aloísio Machado da Silva Filho,
Based on the detrended cross-correlation coefficient, ρxa,xb, we propose in this paper to establish a Detrended Multiple Cross-Correlation coefficient, DMCx2, to be applied in order to quantify the relations between non-stationary signals on different time scales. This Detrended Multiple Cross-Correlation coefficient will be the measure of the total association between the dependent variable, y, with the others i independent variables, x. It will be the generalization of ρxa,xb, for more than two ...
Tópico(s): Chaos control and synchronization
2018 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Aloísio Machado da Silva Filho, M.F. da Silva, Gilney Figueira Zebende,
We propose in this paper to establish the relationship between homicides and attempted homicides by a non-stationary time-series analysis. This analysis will be carried out by Detrended Fluctuation Analysis (DFA), Detrended Cross-Correlation Analysis (DCCA), and DCCA cross-correlation coefficient, ρDCCA(n). Through this analysis we can identify a positive cross-correlation between homicides and attempted homicides. At the same time, looked at from the point of view of autocorrelation (DFA), this analysis ...
Tópico(s): Chaos control and synchronization
2014 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Vilma Takayasu, Lorena Silva Laborda, Raquel Bernardelli, Henrique Trombini Pinesi, Viviane Chiavelli, Angélica Braz Simões, Aloísio Felipe-Silva,
Amyloidosis comprises a group of diseases that occurs in five to nine cases per million patients per year worldwide irrespective of its classification. Although the hepatic involvement in primary amyloidosis is frequent, the clinical manifestations of liver amyloidosis are mild or even absent. The authors report the case of an aged man who complained of diffuse abdominal pain and marked weight loss and presented clinical signs of hepatopathy. Clinical workup revealed portal hypertension with ascites, ...
Tópico(s): Pancreatitis Pathology and Treatment
2016 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Revisado por pares
Rômulo Ribeiro do Vale, N B Conci, Alexandre Pinheiro Santana, Mauricio Baptista Pereira, Natália Yume Hissayasu Menezes, Vilma Takayasu, Lorena Silva Laborda, Aloísio Souza Felipe da Silva,
Celiac disease (CD)-also known as gluten-sensitive enteropathy-is a chronic, genetically predisposing and autoimmune entity with a wide range of clinical manifestations triggered by gluten ingestion, which affects 1% of the general population. Currently, up to 60% of the diagnosis of CD is in adults due to the atypical course of the disease. The severe acute onset of CD-also called celiac crisis-is very uncommon and is still not well documented in adults. We report the case of a 58-year-old man who ...
Tópico(s): Eosinophilic Esophagitis
2018 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Revisado por pares
Vilma Takayasu, Edna Harumi Goto, Mayra Zanon Casagrande, Paulo Guilherme de Arruda Miranda, Gabriela Bezerra de Freitas Diniz, Micaela Frasson Monteiro, Aloísio Felipe-Silva,
Gastric adenocarcinoma is a common neoplasia and is responsible for up to 30% of the overall deaths due to cancer. Advanced disease is mostly characterized by peritoneum, liver, and lung involvement. The spread of the disease to the bone is rare, and bone marrow dissemination is even rarer. In this setting, leukoerythroblastosis may be the initial manifestation of the disease. The authors report the case of a 64-year-old Caucasian man who sought medical care complaining of back pain, weakness, and ...
Tópico(s): Cancer-related molecular mechanisms research
2017 - UNIVERSIDADE DE SÃO PAULO | Autopsy and Case Reports
Produção Nacional
Aloísio da Silva Pinto, Tânia Toledo de Oliveira, Ricardo Junqueira Del Carlo, Tânus Jorge Nagem, Cláudio César Fonseca, George Henrique Kling de Moraes, Davilson Bragine Ferreira, Carlos Antonio Cardoso,
O objetivo deste trabalho foi estudar a influência das combinações: bifosfonato (alendronato de sódio) + estatina (atorvastatina cálcica), bifosfonato (alendronato de sódio) + flavonóide (ipriflavona) e estatina (atorvastatina cálcica) + flavonóide (ipriflavona) em ratas com osteoporose induzida pelo glicocorticóide dexametasona. As influências das associações dessas substâncias foram pesquisadas pela análise de testes dos marcadores bioquímicos de remodelação óssea, tais como, cálcio e fósforo sérico, fosfatase ...
Tópico(s): Bone Metabolism and Diseases
2006 - UNIVERSIDADE DE SÃO PAULO | Revista Brasileira de Ciências Farmacêuticas
Produção Nacional
Revisado por pares
Raquel Costa, Leonardo Barcelos de Paula, Emídio Marques de Matos‐Neto, Joanna D.C.C. Lima, Katrin Radloff, Michele Joana Alves, Rodolfo Gonzalez Camargo, Ana Flávia Marçal Pessoa, Estefanía Simoes, Patrı́cia Gama, Denise Carmona Cara, Aloísio S.F. da Silva, Welbert Oliveira Pereira, Linda Ferreira Maximiano, Paulo Sérgio Martins de Alcântara, José Pinhata Otoch, Giorgio Trinchieri, Alessandro Laviano, Maurizio Muscaritoli, Marília Seelaender,
Abstract Background Cachexia is a multifactorial and multiorgan syndrome associated with cancer and other chronic diseases and characterized by severe involuntary body weight loss, disrupted metabolism, inflammation, anorexia, fatigue, and diminished quality of life. This syndrome affects around 50% of patients with colon cancer and is directly responsible for the death of at least 20% of all cancer patients. Systemic inflammation has been recently proposed to underline most of cachexia‐related ...
Tópico(s): Vitamin C and Antioxidants Research
2019 - Springer Science+Business Media | Journal of Cachexia Sarcopenia and Muscle