Ding Xin-sheng, Jinrong Tang, Hua Ye, Jianhua Su, Ping Zhang, Xuejiang Zhu, Le Wu, Qi Niu, Hang Xiao,
Background: Vasoactive drug alprostadil improves microcirculation and can be effective in treating disorders of peripheral nerves. Vascular endothelial growth factor (VEGF) has been ... Objectives: To study the effect of application of alprostadil on the pathological and functional repair of crush ... randomly divided into: Control; saline; saline + VEGF-antibody; alprostadil; and alprostadil + VEGF antibody groups. The SPSS 11.5 software ... PCR), immunohistochemistry, electromicroscope, and electrophysiology. The effects of alprostadil on expression of VEGF, repair of neural pathology, ...
Tópico(s): Nerve Injury and Rehabilitation
2009 - Medknow | Neurology India
Diane K. Wysowski, Joslyn Swann,
... United States for treatment of erectile dysfunction, namely alprostadil injection and urethral suppository, and sildenafil. MATERIALS AND ... Increases in the number of dispensed prescriptions for alprostadil injection and urethral suppository marketed in 1995 and ... 5 million to 14 million, while those for alprostadil injection decreased 33% from 239,000 to 159,000 and those for alprostadil suppository decreased 67% from 400,000 to 132, ... prescribed proportionately more frequently for younger men than alprostadil injection or suppository (p <0.0001). Compared with ...
Tópico(s): Urinary Bladder and Prostate Research
2003 - Lippincott Williams & Wilkins | The Journal of Urology
Andrew McCullough, Wayne J.G. Hellstrom, Run Wang, Herbert Lepor, Kristofer R. Wagner, Jason D. Engel,
... Radical Prostatectomy and Penile Rehabilitation With Nightly Intraurethral Alprostadil Versus Sildenafil Citrate Andrew R. McCullough, Wayne G. ... trial to compare the effectiveness of nightly intraurethral alprostadil vs sildenafil citrate after nerve sparing prostatectomy. Materials ... treatment within 1 month of surgery with intraurethral alprostadil or oral sildenafil citrate (50 mg) for 9 ... length. Results: Of 139 men who started intraurethral alprostadil and 73 who started sildenafil citrate, 97 and ...
Tópico(s): Genital Health and Disease
2010 - Lippincott Williams & Wilkins | The Journal of Urology
Thomas J. Beckman, Haitham S. Abu-Lebdeh, Lance A. Mynderse,
... 5 inhibitors and other medical treatments, including intraurethral alprostadil, penile injection therapy, and testosterone replacement. Most men ... 5 inhibitors and other medical treatments, including intraurethral alprostadil, penile injection therapy, and testosterone replacement. Male sexual ... Peyronie disease is important because it precludes intraurethral alprostadil and penile injection therapy.Can you engage in ... in the absence of sexual arousal (unlike intraurethral alprostadil and penile injection therapy). Remarkably, patients in whom ...
Tópico(s): Urinary Bladder and Prostate Research
2006 - Elsevier BV | Mayo Clinic Proceedings
Bianca Marasini, Marco Massarotti, B. Bottasso, Richard Coppola, Nicoletta Del Papa, Wanda Maglione, D.P. Comina, Claudio Maioli,
Objective: The prostanoids iloprost and alprostadil are widely used to treat ischaemic changes in patients with Raynaud's phenomenon (RP), but the optimal regimen is poorly defined. ... evaluated whether there are differences between iloprost and alprostadil, in terms of either clinical efficacy or of ... RP were given intravenous iloprost (11 patients) or alprostadil (10 patients) cyclically (5 consecutive days, followed by ... intervals.Results: The overall benefits of iloprost and alprostadil were similar. RP improved in 45% versus 90% ...
Tópico(s): Diagnosis and Treatment of Venous Diseases
2004 - Taylor & Francis | Scandinavian Journal of Rheumatology
MARK D. BENEVIDES, Culley C. Carson,
... UrologyCLINICAL UROLOGY: Original Articles1 Mar 2000INTRAURETHRAL APPLICATION OF ALPROSTADIL IN PATIENTS WITH FAILED INFLATABLE PENILE PROSTHESIS MARK ... cylinder rupture. In these patients intraurethral application of alprostadil may restore prosthesis function and permit satisfactory intercourse. ... erection (MUSE * VIVUS, Inc., Menlo Park, California. ) using alprostadil to restore function for men with a failed ... 2) with a penile prosthesis were treated with alprostadil. Of the patients 11 had penile prosthesis failure ( ...
Tópico(s): Hormonal and reproductive studies
2000 - Lippincott Williams & Wilkins | The Journal of Urology
Ronghe Xu, Guizhou Ma, Zhixiong Cai, Ping Chen, Zhidan Zhu, Wenliang Wang,
... effects of the combined use of hydration and alprostadil in the prevention of CIN following percutaneous coronary ... the ability of a combination of hydration and alprostadil to prevent CIN following PCI in elderly patients. ... control (22 cases), hydration (28 cases) and hydration + alprostadil (35 cases) group. Serum creatinine (SCr) levels were ... the control group but not in the hydration + alprostadil group after PCI. The reduction in the level of Ccr from baseline in the hydration + alprostadil group was the smallest among the three groups. ...
Tópico(s): Trauma, Hemostasis, Coagulopathy, Resuscitation
2013 - Spandidos Publishing | Experimental and Therapeutic Medicine
Bülent Demir, Murat Sinan Engịn, Musa Kemal Keleş, İsmail Küçüker, Engin Yosma,
... channels), piracetam (antiplatelet and regulator of microcirculation) and alprostadil (vasodilator, antiplatelet, rheological and cytoprotective) on flap survival ... piracetam group and 11.3 cm2 in the alprostadil group. When compared with the control group, all drugs except hydralazine improved flap survival; piracetam and alprostadil yielded significantly better results than nifedipine. Only the alprostadil group showed signs of improved vascularity in the ... mechanisms appear more beneficial than single action vasodilators. Alprostadil, a synthetic PGE-1 analogue, has combined antiplatelet ...
Tópico(s): Hemostasis and retained surgical items
2016 - Elsevier BV | Hand surgery & rehabilitation
Francesco Montorsi, Giorgio Guazzoni, Luigi Ferini‐Strambi, L. Da Pozzo, Luciano Nava, Luigi Barbieri, Patrizio Rigatti, G. Pizzini, A Miani,
... PROSTATECTOMY WITH AND WITHOUT EARLY INTRACAVERNOUS INJECTIONS OF ALPROSTADIL: RESULTS OF A PROSPECTIVE, RANDOMIZED TRIAL Francesco Montorsi, ... prospectively the effect of postoperative intracavernous injections of alprostadil on the recovery of spontaneous erectile function after ... radical retropubic prostatectomy and was subsequently randomized to alprostadil injections 3 times per week for 12 weeks ( ... 3 cases, 20%). Complications in patients treated with alprostadil injections accounted for 2 cases (13%) of a ...
Tópico(s): Urinary Bladder and Prostate Research
1997 - Lippincott Williams & Wilkins | The Journal of Urology
PETER Y. TAM, T Keller, R. Poppiti, Neil Gesundheit, Harin Padma-Nathan,
... Urology: Original Articles1 Oct 1998HEMODYNAMIC EFFECTS OF TRANSURETHRAL ALPROSTADIL MEASURED BY COLOR DUPLEX ULTRASONOGRAPHY IN MEN WITH ... Purpose: We evaluated the hemodynamic effects of transurethral alprostadil in 21 patients with erectile dysfunction using color ... compared following intraurethral administration of 500 micro g. alprostadil and intracavernosal injection of 10 micro g. alprostadil. Results: A dose of 500 micro g. transurethral alprostadil resulted in significant increases in corporeal blood flow ...
Tópico(s): Hormonal and reproductive studies
1998 - Lippincott Williams & Wilkins | The Journal of Urology
Wayne J.G. Hellstrom, Run Wang, Craig A. Peterson, John Varady, Neil Gesundheit, Suresh C. Sikka,
... of UrologyClinical Urology: Original Articles1 May 1998EFFECTS OF ALPROSTADIL AND PRAZOSIN ON MOTILITY, VIABILITY AND MEMBRANE INTEGRITY ... InTwitterEmail Abstract Purpose: We evaluated the effects of alprostadil, prazosin hydrochloride, and alprostadil/prazosin hydrochloride, agents used in the clinical treatment ... that were incubated with 0.4 mg./ml. alprostadil, 0.1 and 0.2 mg./ml. prazosin hydrochloride and 0.4 mg./ml. alprostadil plus 0.1 mg./ml. prazosin hydrochloride for ... the formulation vehicle for the clinical use of alprostadil and prazosin, and Ham's F-10 buffer. ...
Tópico(s): Sperm and Testicular Function
1998 - Lippincott Williams & Wilkins | The Journal of Urology
Jason D. Engel, Kevin T. McVary,
... We evaluated the efficacy and safety of transurethral alprostadil (MUSE) in patients experiencing erectile dysfunction who underwent prior ICI therapy (alprostadil, papaverine, phentolamine, or a combination of these). Methods. ... patients enrolled in a multicenter trial of transurethral alprostadil, 452 (30%) reported prior ICI therapy and its ... tested up to four dose levels of transurethral alprostadil in the clinic, and those who achieved an ... achieved an erection sufficient for intercourse following transurethral alprostadil therapy in the clinic; 47% of these responsive ...
Tópico(s): Hormonal and reproductive studies
1998 - Elsevier BV | Urology
Irène Buvat, P. Costa, D Morlier, Brigitte Lecocq, Barbara J. Stegmann, Detlef Albrecht,
... Original Articles1 Jan 1998DOUBLE-BLIND MULTICENTER STUDY COMPARING ALPROSTADIL α-CYCLODEXTRIN WITH MOXISYLYTE CHLORHYDRATE IN PATIENTS WITH ... Purpose: We compared the efficacy and safety of alprostadil alpha-cyclodextrin and moxisylyte chlorhydrate to induce erections ... receiving titrations of an individual optimum dose of alprostadil alpha-cyclodextrin or moxisylyte chlorhydrate. Erectile response was ... A total of 56 patients (75%) in the alprostadil alpha-cyclodextrin group and 32 patients (40%) in ... during the office period. Investigators assessed erections after alprostadil alpha-cyclodextrin to be adequate for sexual intercourse ...
Tópico(s): Sexuality, Behavior, and Technology
1998 - Lippincott Williams & Wilkins | The Journal of Urology
Craig A. Peterson, Alan H. Bennett, Wayne J.G. Hellstrom, Fran E. Kaiser, John E. Morley, Kerry J. Nemo, Harin Padma-Nathan, Virgil A. Place, J. Joseph Prendergast, PETER Y. TAM, Emil A. Tanagho, Leslie Todd, John Varady, Neil Gesundheit,
... Urology: Original Articles1 May 1998ERECTILE RESPONSE TO TRANSURETHRAL ALPROSTADIL, PRAZOSIN AND ALPROSTADIL-PRAZOSIN COMBINATIONS CRAIG A. PETERSON, ALAN H. BENNETT, ... favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Transurethral alprostadil has been shown to be efficacious in many men with erectile dysfunction. We compared transurethral alprostadil and prazosin alone, and in combination to treat ... placebo controlled study the erectile responses to transurethral alprostadil, prazosin and alprostadil-prazosin combinations were assessed in ...
Tópico(s): Hormonal and reproductive studies
1998 - Lippincott Williams & Wilkins | The Journal of Urology
Holger Lawall, A. Pokrovsky, Paweł Chęciński, A. Ratushnyuk, Grégory Hamm, Olaf Randerath, Frank Grieger, Jürgen W. G. Bentz,
... was to assess the efficacy and safety of alprostadil in patients with peripheral arterial occlusive disease (PAOD) ... were equally randomised to either 4 weeks of alprostadil treatment twice daily or to placebo treatment twice ... complete healing" was 18.4% in patients on alprostadil and 17.2% in patients on placebo. The ... major amputations" were 12.6% in patients on alprostadil and 14.6% in patients on placebo. The adjusted difference between alprostadil and placebo including their 95% confidence intervals was ...
Tópico(s): Coronary Interventions and Diagnostics
2017 - Elsevier BV | European Journal of Vascular and Endovascular Surgery
Xiu-Juan Yan, Yingxiu Li, Yun Ho Choi, Chongyang Wang, Yihua Piao, Jing Ye, Jingzhi Jiang, Liangchang Li, Huixian Xu, Qingsong Cui, Guanghai Yan, Minggen Jin,
... This study investigated the role and mechanism of alprostadil in acute respiratory distress syndrome (ARDS) induced by ... randomly divided into control, OA model, and OA + Alprostadil (2.5, 5, and 10 μg/kg, respectively) ... induced by femoral vein injection of OA, and alprostadil was administrated immediately. Lung injury was evaluated by ... deposition at 3 h after OA injection. However, alprostadil (10 μg/kg) treatment significantly reduced OA-induced ... TNF-α and IL-1β were suppressed by alprostadil. The OA-induced activation of nuclear factor (NF) ...
Tópico(s): Cardiac Ischemia and Reperfusion
2018 - International Scientific Information Inc. | Medical Science Monitor
Arthur L. Burnett, Ajay Nehra, Rodney H. Breau, Daniel J. Culkin, Martha M. Faraday, Lukman Hakim, Joel J. Heidelbaugh, Mohit Khera, Kevin T. McVary, Martin Miner, Christian J. Nelson, Hossein Sadeghi‐Nejad, Allen D. Seftel, A.W. Shindel,
... informed regarding the treatment option of intraurethral (IU) alprostadil, including discussion of benefits and risks/burdens. (Conditional ... ED who are considering the use of IU alprostadil, an in-office test should be performed. (Clinical ... delivery catheter into the meatus and depositing an alprostadil (prostaglandin E1) pellet in the urethra to induce an erection sufficient for intercourse. IU alprostadil is a treatment option for men for whom ... largest study to assess the efficacy of IU alprostadil reported that of the 461 men assigned to ...
Tópico(s): Urinary Bladder and Prostate Research
2018 - Lippincott Williams & Wilkins | The Journal of Urology
Luba A. Kielbasa, Karen L. Daniel,
... the pharmacology, pharmacokinetics, efficacy, and safety of topical alprostadil in the treatment of female sexual arousal disorder ( ... and International Pharmaceutical Abstracts with the search terms alprostadil, female, and sexual dysfunction/drug therapy.All published ... abstracts involving the efficacy and safety of topical alprostadil use in women were reviewed. Data on file with the manufacturer were also included.Topical alprostadil is a vasodilatory agent under development for the treatment of FSAD. In-clinic application of alprostadil increases genital vasocongestion, vaginal erythema, transudates, and some ...
Tópico(s): Urinary Bladder and Prostate Research
2006 - SAGE Publishing | Annals of Pharmacotherapy
Cheng-Chu Hsieh, Shu‐Chen Hsieh, Jen‐Hwey Chiu, Ying-Ling Wu,
... acetylcysteine (NAC) and the prostaglandin E1 (PGE1) analog alprostadil on hepatic I/R injury in rats. Thirty ... R group, I/R + NAC group, I/R + alprostadil group, and I/R + NAC + alprostadil group. The rats received injections of NAC (150 mg/kg) and/or alprostadil (0.05 μg/kg) over a period of ... were decreased in the groups with NAC treatment. Alprostadil decreased NO production, but had no effect on ... MPO. Histological results showed that both NAC and alprostadil were effective in improving liver tissue morphology during ...
Tópico(s): Liver Disease and Transplantation
2014 - Elsevier BV | Journal of Traditional and Complementary Medicine
Weijing Liu, Bu‐Chun Zhang, Rong Guo, Yidong Wei, Wei‐Ming Li, Yawei Xu,
Background The role of alprostadil and statins in contrast-induced acute kidney injury (CI-AKI) is controversial. The purpose of this study was to explore the efficacy of combined therapy with alprostadil and statins in protecting renal function and preventing ... statins before and after coronary angiography. In the alprostadil plus statins group, 76 patients were treated with statins and alprostadil before and after coronary angiography. Serum creatinine (SCr), ... CysC and NGAL were significantly lower in the alprostadil plus statins group than in the statins group ( ...
Tópico(s): Chronic Kidney Disease and Diabetes
2013 - Lippincott Williams & Wilkins | Chinese Medical Journal
Zhenbai Qin, Binghui Kong, Jing Zheng, Xiantao Wang, Lang Li,
... in progressive contractile dysfunction associated with cardiomyocyte apoptosis. Alprostadil injection improves microcirculation, which is effective in treating various cardiovascular disorders. However, the therapeutic effects of alprostadil in CME-induced myocardia injury remain unknown. Therefore, we evaluated the effects of alprostadil injection on cardiac protection in a rat model ... ventricle. After injection of microspheres, rats in the alprostadil group received alprostadil via tail vein within 2 ...
Tópico(s): Cardiovascular Function and Risk Factors
2020 - Dove Medical Press | Drug Design Development and Therapy
Daniel P. Andersson, L Landucci, Ylva Trolle Lagerros, Alessandra Grotta, Rino Bellocco, Mikael Lehtihet, Martin J. Holzmann,
... investigate the association between treatment with PDE5i or alprostadil and outcomes in men with stable coronary artery ... prior MI or revascularization who received PDE5i or alprostadil during 2006 through 2013 at >6 months after ... and stroke in men treated with PDE5i versus alprostadil. This study included 16,548 men treated with PDE5i and 1,994 treated with alprostadil. The mean follow-up was 5.8 years, ... the PDE5i group and 521 (26%) in the alprostadil group. PDE5i compared with alprostadil treatment was associated ...
Tópico(s): Pharmacology and Obesity Treatment
2021 - Elsevier BV | Journal of the American College of Cardiology
Michael W. Rooney, William Pfister, Mary C. Mahoney, Melissa Nelson, James L. Yeager, Christopher P. Steidle,
Alprostadil is approved for treatment of male erectile dysfunction (ED) by injection or urethral insertion. Topical delivery of alprostadil offers an improved alternative.To evaluate the long-term safety and efficacy of topical alprostadil cream.This was a multicenter, open-label, long- ... patients could administer eight doses of 200 mcg alprostadil to the penis meatus before intercourse (up to ... The majority of patients (73%) selected 300 mcg alprostadil as the final dose. The most common AEs ... adjusting dose strength to their individual responsiveness.Topical alprostadil cream was considered effective and safe by most ...
Tópico(s): Urinary Bladder and Prostate Research
2008 - Elsevier BV | The Journal of Sexual Medicine
To determine the physical compatibility of alprostadil with intravenous (IV) solutions, a parenteral nutrition (PN) solution, and other intravenous medications commonly used in the neonatal intensive care unit (NICU). ... PN solution were slowly mixed 1:1 with alprostadil 15 μg/mL at 25°C. The mixtures ... parenteral nutrition solution mixtures were not tested with alprostadil. The mixtures were examined for physical incompatibility as described above.Alprostadil was visually compatible with D5W 0.45% NaCl, ...
Tópico(s): Anesthesia and Sedative Agents
2006 - | The Journal of Pediatric Pharmacology and Therapeutics
Changqing Luo, Ting Li, Chun Zhang, Qing Chen, Zhenqiong Li, Jianshe Liu, Yumei Wang,
... nephropathy (DN) and the molecular mechanisms through which alprostadil protects renal function. Methods: DN was induced by streptozotocin and intraperitoneal injection of alprostadil was given to diabetic mice. After 2, 4 and 8 weeks of alprostadil treatment, the mRNA and protein expression of kidney ... were cultured in high glucose and treated with alprostadil. After transfection with an Ang-2-pcDNA and ... expression were measured by Western blot analyses. Results: Alprostadil treatment caused a significant decrease in the renal ...
Tópico(s): Angiogenesis and VEGF in Cancer
2014 - Karger Publishers | Cellular Physiology and Biochemistry
Albert J. Augustin, Curt Diehm, Frank Grieger, Jürgen W. G. Bentz,
... was to assess efficacy and safety of intravenous alprostadil infusion in patients with dAMD. Methods: This was ... treated with intravenous infusion of either 60 µg alprostadil or placebo over 3 weeks. Main efficacy outcomes ... analysis of variance-covariance (ANCOVA) resulted in the alprostadil group (n = 16) and a mean difference of - ... months after end of treatment. Thus, effectiveness of alprostadil infusion was numerically superior to placebo treatment by ... in line with the good safety profile of alprostadil. Conclusion: A numerical treatment effect in favor of ...
Tópico(s): Glaucoma and retinal disorders
2013 - Taylor & Francis | Expert Opinion on Investigational Drugs
Mustafa Arslan, Dilek Erer, Abdullah Özer, Hüseyin Demirtaş, İpek Işık Gönül, Halil Kara, Ayşe Hande Arpacı, Faruk Metin Çomu, Gürsel Levent Oktar, Ayşegül Küçük,
Objectives: To evaluate the effects of alprostadil (prostaglandin [PGE1] analog) and iloprost (prostacyclin [PGI2] analog) on renal, lung, and skeletal muscle tissues after ischemia reperfusion (I/R) injury in ... aorta clamping with subsequent 2 hours of reperfusion. Alprostadil and iloprost were given starting simultaneously with the ... tubular dilatation scores were significantly lower in the alprostadil-treated group than those found in the I/ ... edema, and hemorrhage scores were significantly lower in alprostadil- and iloprost-treated groups ( P =0.017 and ...
Tópico(s): Electrolyte and hormonal disorders
2016 - Dove Medical Press | Drug Design Development and Therapy
Min Liang, Shicheng Yang, Naikuan Fu, Chengzhi Lu, Fengshi Tian, Xing Xiaochun, Wenhua Lin, Jingjing Liu,
The role of alprostadil on the prevention of contrast-induced nephropathy (CIN) still remains controversial. The purpose of this study was to examine the effects of short-term alprostadil on the incidence of CIN in patients undergoing ... 240) was given only hydration therapy and the alprostadil group (n = 240) received intravenous administration of 20 ... incidence of CIN was significantly lower in the alprostadil group than that in the control group (6. ... 0.038). Multivariate logistic regression analysis showed that alprostadil was the protective factor of CIN (OR = 0. ...
Tópico(s): Renal and Vascular Pathologies
2017 - Wiley | Catheterization and Cardiovascular Interventions
Mehmet Ali Karagöz, Ömer Gökhan Doluoğlu, Hatǐce Ünverdǐ, Berkan Reşorlu, Melih Sunay, Arif Demirbaş, Tolga Karakan, Arif Aydın,
Objective: To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats. Materials ... T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. ... 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the ... T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p= ... 14%) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino ...
Tópico(s): Sperm and Testicular Function
2018 - Sociedade Brasileira de Urologia | International braz j urol
Tao Yu, Dan Dong, Jialiang Guan, Jialin Sun, Mingzhou Guo, Q Wang,
Abstract Background Clinical research has demonstrated that alprostadil has an anti-inflammatory effect; however, to date, its molecular mechanisms remain unclear. This study aimed to examine the anti-inflammatory activity and related mechanisms of alprostadil in lipopolysaccharide (LPS)-treated H9c2 cells. Methods Cell ... polymerase chain reaction (RT-PCR). The effects of alprostadil on the Wnt5a/JNK/NF-κB pathway in H9c2 cells was examined by Western blotting. Results Alprostadil increased the cell viability of LPS-stimulated H9c2 ...
Tópico(s): Neuropeptides and Animal Physiology
2019 - Springer Science+Business Media | Herz