Produção Nacional
Revisado por pares
Luciana Pellegrini Pisani, Cláudia Maria Oller do Nascimento, Allain Amador Bueno, Carolina Biz, Kelse Tibau de Albuquerque, Eliane Beraldi Ribeiro, Lila Missae Oyama,
Abstract We examine whether feeding pregnant and lactating rats hydrogenated fats rich in trans fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 90-day-old offspring. Pregnant and lactating Wistar rats were fed with either a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). Upon weaning, the male pups were sorted into four groups: CC, mothers were receiving C and pups ...
Tópico(s): Fatty Acid Research and Health
2008 - BioMed Central | Lipids in Health and Disease
Produção Nacional
Revisado por pares
Luciana Pellegrini Pisani, Lila Missae Oyama, Allain Amador Bueno, Carolina Biz, Kelse Tibau de Albuquerque, Eliane Beraldi Ribeiro, Cláudia Maria Oller do Nascimento,
We examined whether feeding pregnant and lactating rats hydrogenated fats rich in trans-fatty acids modifies the plasma lipid profiles and the expression of adipokines involved with insulin resistance and cardiovascular disease in their 21-d-old offspring.Pregnant and lactating Wistar rats were fed with a control diet (C group) or one enriched with hydrogenated vegetable fat (T group). After delivery, male offspring were weighed weekly and killed at day 21 of life by decapitation. Blood and retroperitoneal, ...
Tópico(s): Adipose Tissue and Metabolism
2008 - Elsevier BV | Nutrition
Produção Nacional
Revisado por pares
Carla Roberta de Oliveira Carvalho, Allain Amador Bueno, Ana Marcondez Mattos, Carolina Biz, Cristiane de Oliveira, Luciana Pellegrini Pisani, Eliane Beraldi Ribeiro, Cláudia Maria Oller do Nascimento, Lila Missae Oyama,
Fructose- or sucrose-rich diets can cause insulin resistance and increase the risk of cardiovascular disease. Adipokines are correlated with the development of these diseases in obesity. We hypothesize that fructose and sucrose induce insulin resistance via effects on adipokine gene expression in adipocytes. This study analyzed the effect of fructose or glucose on adiponectin, haptoglobin, and angiotensinogen gene expression in 3T3-L1 adipocytes. Ten days after differentiation, the cells were pretreated ...
Tópico(s): Metabolism, Diabetes, and Cancer
2010 - Elsevier BV | Nutrition Research
Produção Nacional
Revisado por pares
Allain Amador Bueno, Lila Missae Oyama, Cristiane de Oliveira, Luciana Pellegrini Pisani, Eliane Beraldi Ribeiro, Vera L.F. Silveira, Cláudia Maria Oller do Nascimento,
Tópico(s): Regulation of Appetite and Obesity
2007 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology
Produção Nacional
Revisado por pares
Débora Estadella, Lila Missae Oyama, Allain Amador Bueno, Carlos Alexandre Habitante, Gabriel Inacio de Morais Honorato de Souza, Eliane Beraldi Ribeiro, Caio SM Motoyama, Cláudia Maria Oller do Nascimento,
Abstract Background We have previously shown that either the continuous intake of a palatable hyperlipidic diet (H) or the alternation of chow (C) and an H diet (CH regimen) induced obesity in rats. Here, we investigated whether the time of the start and duration of these feeding regimens are relevant and whether they affect brain glucose metabolism. Methods Male Wistar rats received C, H, or CH diets during various periods of their life spans: days 30-60, days 30-90, or days 60-90. Experiments were ...
Tópico(s): Adipose Tissue and Metabolism
2011 - BioMed Central | Lipids in Health and Disease
Allain Amador Bueno, Kebreab Ghebremeskel, Khalid Hussein Bakheit, Mustafa I. Elbashir, I. Adam,
In Sudanese women with (n = 60) and without (n = 65) pre-eclampsia, circulating lipids, plasma and red cell saturated and monounsaturated fatty (MUFA) acids and dimethyl acetals (DMAs) were investigated. DMAs are an indirect marker of levels of plasmalogens, endogenous antioxidants, which play a critical role in oxidative protection, and cholesterol homeostasis. The pre-eclamptics had higher C18:1n-9 (p < 0.001) and ΣMUFA (p < 0.01) in plasma free fatty acids, C16:1n-7, C18:1n-9, ΣMUFA; 16:0/16:1n-7 (p < 0.01) in ...
Tópico(s): Birth, Development, and Health
2012 - Informa | Journal of Obstetrics and Gynaecology
Produção Nacional
Revisado por pares
Allain Amador Bueno, Lila Missae Oyama, Débora Estadella, Carlos Alexandre Habitante, B.S.S. Bernardes, E.B. Ribeiro, Cláudia Maria Oller do Nascimento,
We analyzed the effects of partial fat pad removal on retroperitoneal and epididymal fat depots and carcass metabolism of control (C) and MSG-obese (M) rats. Three-month-old C and M male Wistar rats were submitted to either partial surgical excision of epididymal and retroperitoneal fat tissue (lipectomy, L) or sham surgery (S) and studied after 7 or 30 days. Retroperitoneal and epididymal tissue re-growth after lipectomy was not observed, as indicated by the low pads weight of the L groups. The lipolysis ...
Tópico(s): Adipose Tissue and Metabolism
2005 - Institute of Physiology of the Czech Academy of Sciences | Physiological Research
Produção Nacional
Revisado por pares
Aline Corado Gomes, Allain Amador Bueno, Rávila Graziany Machado de Souza, João Felipe Mota,
Diabetes is a condition of multifactorial origin, involving several molecular mechanisms related to the intestinal microbiota for its development. In type 2 diabetes, receptor activation and recognition by microorganisms from the intestinal lumen may trigger inflammatory responses, inducing the phosphorylation of serine residues in insulin receptor substrate-1, reducing insulin sensitivity. In type 1 diabetes, the lowered expression of adhesion proteins within the intestinal epithelium favours a ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2014 - BioMed Central | Nutrition Journal
Allain Amador Bueno, Annette Brand, M. Neville, Catherine Lehane, Nina Brierley, M. A. Crawford,
The majority of children with Down syndrome (DS) develop Alzheimer's disease (AD) at an early age. Although long-chain n -3 fatty acids (FA) are protective of neurodegeneration, little is known about the FA status in DS. In the present study, we aimed to investigate whether children with DS presented altered plasma and erythrocyte membrane phospholipids (PL) FA composition, when compared with their non-affected siblings. Venous blood samples were analysed for plasma and erythrocyte membrane FA composition ...
Tópico(s): Diabetes Management and Research
2014 - Cambridge University Press | British Journal Of Nutrition
Rachel V. Gow, Frédéric Vallée‐Tourangeau, M. A. Crawford, Eric Taylor, Kebreab Ghebremeskel, Allain Amador Bueno, Joseph R. Hibbeln, Alexander Sumich, Katya Rubia,
A number of research studies have reported abnormal plasma fatty acid profiles in children with ADHD along with some benefit of n−3 to symptoms of ADHD. However, it is currently unclear whether (lower) long chain-polyunsaturated fatty acids (LC-PUFAs) are related to ADHD pathology or to associated behaviours. The aim of this study was to test whether (1) ADHD children have abnormal plasma LC-PUFA levels and (2) ADHD symptoms and associated behaviours are correlated with LC-PUFA levels. Seventy-two, ...
Tópico(s): Child Abuse and Trauma
2013 - Elsevier BV | Prostaglandins Leukotrienes and Essential Fatty Acids
Rachel V. Gow, Alexander Sumich, Frédéric Vallée‐Tourangeau, M. A. Crawford, Kebreab Ghebremeskel, Allain Amador Bueno, Joseph R. Hibbeln, Eric Taylor, Daniel A. Wilson, Katya Rubia,
Background In addition to the core symptoms, attention deficit hyperactivity disorder (ADHD) is associated with poor emotion regulation. There is some evidence that children and young adults with ADHD have lower omega-3 levels and that supplementation with omega-3 can improve both ADHD and affective symptoms. We therefore investigated differences between ADHD and non-ADHD children in omega-3/6 fatty acid plasma levels and the relationship between those indices and emotion-elicited event-related potentials ( ...
Tópico(s): Early Childhood Education and Development
2013 - Elsevier BV | Prostaglandins Leukotrienes and Essential Fatty Acids
Produção Nacional
Revisado por pares
Ana Paula Segantine Dornellas, Regina Watanabe, Gustavo D. Pimentel, Valter Tadeu Boldarine, Cláudia Maria Oller do Nascimento, Lila Missae Oyama, Kebreab Ghebremeskel, Y. Wang, Allain Amador Bueno, Eliane Beraldi Ribeiro,
Tópico(s): Dietary Effects on Health
2015 - Elsevier BV | Prostaglandins Leukotrienes and Essential Fatty Acids
Produção Nacional
Revisado por pares
Andrew Chao, Dan Linetzky Waitzberg, Rosângela Passos de Jesús, Allain Amador Bueno, Victor Kha, Karen Allen, Matthew R. Kappus, Valentina Medici,
Malnutrition is associated with alcoholic liver disease (ALD) and related complications such as hepatic encephalopathy and increased rate of infections. Avoidance of prolonged fasting and overly restrictive diets is important to avoid poor nutrition. Adequate intake of calories, protein, and micronutrients via frequent small meals and evening supplements and/or enteral and parenteral nutrition when indicated has been associated with reduced mortality and morbidity in patients with ALD. Modification ...
Tópico(s): Liver Disease and Transplantation
2016 - Springer Science+Business Media | Current Gastroenterology Reports
Produção Nacional
Revisado por pares
Heitor O. Santos, Allain Amador Bueno, João Felipe Mota,
Cardiovascular disease is a highly prevalent issue worldwide, and one of its main manifestations, dyslipidaemia, needs more attention. Cooked artichoke (Cynara scolymus) hearts or artichoke leaf extract (ALE) are believed to be helpful in the treatment of dyslipidaemia. In this narrative review, we provide a brief overview of the potential impact of artichoke consumption on lipid profile. We appraised the Cochrane, MEDLINE and Web of Science databases, and included articles published between 2000 ...
Tópico(s): Coenzyme Q10 studies and effects
2018 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Filipe Lopes Sakamoto, Rodrigo Metzker Pereira Ribeiro, Allain Amador Bueno, Heitor O. Santos,
Anxiety disorders are highly prevalent in modern societies, and are ranked the sixth most important contributor of non-fatal negative health outcomes. L-theanine is an amino acid naturally found in green tea (Camellia sinensis) and some other plant extracts, and recent clinical studies have proposed promising adjuvant effects of L-theanine for the negative impact of anxiety and psychological stress on health. In this integrative narrative review, we aimed to appraise and further discuss the effects ...
Tópico(s): GABA and Rice Research
2019 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Bruna Kelly Sousa Hirata, Maysa Mariana Cruz, Roberta D. C. C. de Sá, Talita S. M. Farias, Meira M.F. Machado, Allain Amador Bueno, Maria Isabel Cardoso Alonso‐Vale, Mônica Marques Telles,
Exacerbated expansion of adipose tissue seen in diet-induced obesity leads to endocrine dysfunction and disturbance in adipokine secretion, with such abnormal profile positively associated with type 2 diabetes and other mild chronic inflammatory conditions. Ginkgo biloba extract (GbE), a mixture of polyphenols with antioxidant properties, has been recently investigated in a variety of experimental models of endocrine dysfunction, with several potentially beneficial effects identified, including improvement ...
Tópico(s): Neurological Disease Mechanisms and Treatments
2019 - Frontiers Media | Frontiers in Endocrinology
Produção Nacional
Revisado por pares
Rafael Genário, Ediane Morello, Allain Amador Bueno, Heitor O. Santos,
Disorders of the female reproductive system, including those associated with hormone regulation, fertility rate and fetal health, are issues of great concern worldwide. More recently, melatonin supplementation has been suggested as a therapeutic approach in gynecological practice. In both animal models and in women, melatonin supplementation suggests a therapeutic and preventative potential, effects attributed mainly to its antioxidant properties and action as hormone modulator. The aim of this ...
Tópico(s): Birth, Development, and Health
2019 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Rafael Genário, José Cipolla‐Neto, Allain Amador Bueno, Heitor O. Santos,
Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In the present review, we have amalgamated the evidence so far available on physiological effects of melatonin supplementation in obesity therapies, addressing its effects upon neuroendocrine ...
Tópico(s): Sleep and Wakefulness Research
2020 - Elsevier BV | Pharmacological Research
Produção Nacional
Revisado por pares
Heitor O. Santos, James C. Price, Allain Amador Bueno,
Cardiovascular diseases remain a global challenge, and lipid-associated biomarkers can predict cardiovascular events. Extensive research on cardiovascular benefits of omega-3 polyunsaturated fatty acids (n3-PUFAs) is geared towards fish oil supplementation and fish-rich diets. Nevertheless, vegetarianism and veganism are becoming more popular across all segments of society, due to reasons as varied as personal, ethical and religious values, individual preferences and environment-related principles, ...
Tópico(s): Cholesterol and Lipid Metabolism
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
Valter Tadeu Boldarine, Amanda Paula Pedroso, Caroline Brandão‐Teles, E.G. Lo Turco, Cláudia Maria Oller do Nascimento, Lila Missae Oyama, Allain Amador Bueno, Daniel Martins‐de‐Souza, Eliane Beraldi Ribeiro,
Menopause is often accompanied by visceral obesity. With the aim of exploring the consequences of ovarian failure on visceral fat, we evaluated the effects of ovariectomy and estrogen replacement on the proteome/phosphoproteome and on the fatty acid profile of the retroperitoneal adipose depot (RAT) of rats. Eighteen 3-mo-old female Wistar rats were either ovariectomized or sham operated and fed with standard chow for 3 mo. A subgroup of ovariectomized rats received estradiol replacement. RAT samples ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2020 - American Physiological Society | AJP Endocrinology and Metabolism
Produção Nacional
Revisado por pares
Heitor O. Santos, Grant M. Tinsley, Guilherme Almeida Rosa da Silva, Allain Amador Bueno,
A scientific interest has emerged to identify pharmaceutical and nutritional strategies in the clinical management of coronavirus disease 2019 (COVID-19). The purpose of this narrative review is to critically assess and discuss pharmaconutrition strategies that, secondary to accepted treatment methods, could be candidates in the current context of COVID-19. Oral medicinal doses of vitamin C (1–3 g/d) and zinc (80 mg/d elemental zinc) could be promising at the first signs and symptoms of COVID-19 as ...
Tópico(s): Intensive Care Unit Cognitive Disorders
2020 - Multidisciplinary Digital Publishing Institute | Journal of Personalized Medicine
Produção Nacional
Revisado por pares
Heitor O. Santos, Theresa L. May, Allain Amador Bueno,
Omega-3 polyunsaturated fatty acids (n-3 PUFA) play a significant role in the prevention and management of cardiometabolic diseases associated with a mild chronic pro-inflammatory background, including type 2 diabetes, hypertension, hypertriglyceridaemia, and fatty liver disease. The effects of n-3 PUFA supplements specifically, remain controversial regarding reducing risks of cardiovascular events. n-3 PUFA supplements come at a cost for the consumer and can result in polypharmacy for patients on ...
Tópico(s): Diet, Metabolism, and Disease
2023 - Frontiers Media | Frontiers in Nutrition
Produção Nacional
Revisado por pares
Tatiane Correia Rios, Lucivalda Pereira Magalhães de Oliveira, Maria Lúcia Varjão da Costa, Ramona Souza da Silva Baqueiro Boulhosa, Anna Karla Carneiro Roriz, Lílian Barbosa Ramos, Allain Amador Bueno,
Abstract Rationale Quality of Life (QoL) is impaired in cancer, and the elderly are particularly vulnerable to malnutrition. A diagnosis of cancer in elderly patients further exacerbates risks of negative health outcomes. Here we investigated associations between QoL and nutritional status in a sample population of mostly socially deprived elderly cancer patients. Method 432 cancer patients were recruited for this cross-sectional study at point of admission to a tertiary referral hospital for cancer ...
Tópico(s): Cancer survivorship and care
2021 - BioMed Central | Health and Quality of Life Outcomes
Produção Nacional
Revisado por pares
Camila Ribeiro de Avelar, Beatriz Vieira Coelho Nunes, Betina da Silva Sassaki, Mariana dos Santos Vasconcelos, Lucivalda Pereira Magalhães de Oliveira, André Castro Lyra, Allain Amador Bueno, Rosângela Passos de Jesús,
Non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent liver diseases globally. Pharmacological treatments for NAFLD are still limited. Silymarin, a compound extracted from Silybum marianum, is an herbal supplement traditionally used in folk medicine for liver disorders. It has been proposed that silymarin may possess hepatoprotective and anti-inflammatory properties. The present trial aims to assess the efficacy of silymarin supplementation in the adjuvant treatment of NAFLD in adult ...
Tópico(s): Silymarin and Mushroom Poisoning
2023 - Springer Science+Business Media | Trials
Produção Nacional
Revisado por pares
Allain Amador Bueno, Lila Missae Oyama, Caio Sussumu de Macedo Motoyama, Carolina Biz, Vera L.F. Silveira, Eliane Beraldi Ribeiro, Cláudia Maria Oller do Nascimento,
Tópico(s): Diet, Metabolism, and Disease
2009 - Springer Science+Business Media | European Journal of Nutrition
Produção Nacional
Revisado por pares
Allain Amador Bueno, Carlos Alexandre Habitante, Lila Missae Oyama, Débora Estadella, Eliane Beraldi Ribeiro, Cláudia Maria Oller do Nascimento,
The effects of partial removal of epididymal (EPI) and retroperitoneal (RET) adipose tissues (partial lipectomy) on the triacylglycerol deposition of high fat diet induced obese rats were analyzed, aiming to challenge the hypothesized body fat regulatory system. Male 28-day-old wistar rats received a diet enriched with peanuts, milk chocolate and sweet biscuits during the experimental period. At the 90th day of life, rats were submitted to either lipectomy (L) or sham surgery. After 7 or 30 days, RET, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2010 - BioMed Central | The Journal of Physiological Sciences
Produção Nacional
Revisado por pares
Matthew Stults‐Kolehmainen, Miguel Blacutt, John B. Bartholomew, Daniel Boullosa, Petr Janata, Brian B. Koo, Paul McKee, Regina C. Casper, Christopher J. Budnick, Todd A. Gilson, Rebekah L. Blakemore, Alberto Filgueiras, Susannah Williamson, Nicholas J. SantaBarbara, Jessica L. Barker, Fabio Amador Bueno, Jennifer Heldring, Garrett I. Ash,
Motivation for bodily movement, physical activity and exercise varies from moment to moment. These motivation states may be “affectively-charged,” ranging from instances of lower tension (e.g., desires, wants) to higher tension (e.g., cravings and urges). Currently, it is not known how often these states have been investigated in clinical populations (e.g., eating disorders, exercise dependence/addiction, Restless Legs Syndrome, diabetes, obesity) vs. healthy populations (e.g., in studies of motor control; ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2022 - Frontiers Media | Frontiers in Psychology
N Ionescu, Caterina de Freitas, Allain Amador Bueno,
Docosahexaenoic (DHA) and arachidonic acids (AA) are polyunsaturated fatty acids (PUFAs), major components of brain tissue and neural systems, and the precursors of a number of biologically active metabolites with functions in inflammation resolution, neuroprotection and other actions. As PUFAs are highly susceptible to peroxidation, we hypothesised whether cigarette smokers would present altered PUFAs levels in plasma and erythrocyte phospholipids. Adult males from Indian, Sri-Lankan or Bangladeshi ...
Tópico(s): Cholesterol and Lipid Metabolism
2013 - Springer Nature | Indian Journal of Clinical Biochemistry
Alex J. Wadley, Adrian Holliday, Gareth Morgan, Kate J. Heesom, Sarah Aldred, D.M. Peters, Allain Amador Bueno, Steven Coles,
This study investigated immunophenotypic differences in intracellular thiol redox state of peripheral blood mononuclear cells (PBMCs) isolated from trained [ n = 9, means ± SD: age 28 ± 5 yr; (body mass index) BMI 23.2 ± 2.6 kg/m2; V̇o2max (maximal oxygen intake)56.9 ± 6.1 ml·kg-1·min-1] and recreationally active (RA, n = 11, means ± SD: age 27 ± 6 yr; BMI 24.2 ± 3.7 kg/m2; V̇o2max 45.1 ± 6.4 ml·kg-1·min-1) participants before and after a maximal aerobic exercise tolerance test. Blood samples were taken before (Pre), during ( ...
Tópico(s): Muscle metabolism and nutrition
2018 - American Physiological Society | Journal of Applied Physiology
Matthew Stults‐Kolehmainen, Todd A. Gilson, Nicholas J. SantaBarbara, Paul McKee, Rajita Sinha, John B. Bartholomew, Daniel Boullosa, Christopher J. Budnick, Fabio Amador Bueno, Adrian Haughton, Jessica L. Barker, Garrett I. Ash,
Motivation for physical activity and sedentary behaviors (e.g., desires, urges, wants, cravings) varies from moment to moment. According to the WANT model, these motivation states may be affectively-charged (e.g., felt as tension), particularly after periods of maximal exercise or extended rest. The purpose of this study was to examine postulates of the WANT model utilizing a mixed-methods approach. We hypothesized that: (1) qualitative evidence would emerge from interviews to support this model, and ( ...
Tópico(s): Physical Activity and Health
2023 - Frontiers Media | Frontiers in Sports and Active Living