Takashi Tagami, Hiroki Matsui, Yuuta Moroe, Reo Fukuda, Ami Shibata, Chie Tanaka, Kyoko Unemoto, Kiyohide Fushimi, Hideo Yasunaga,
Previous studies have suggested that antithrombin may be beneficial for treating coagulopathy in patients with severe burns. However, robust evidence for this idea is lacking. We examined the hypothesis that antithrombin may be effective in treating patients with severe burns.We performed propensity score-matched analyses of the nationwide administrative Japanese Diagnosis Procedure Combination inpatient database. We identified patients with severe burns (burn index ≥ 10) who were recorded in the database ...
Tópico(s): Cardiac Arrest and Resuscitation
2017 - Springer Nature | Annals of Intensive Care
Ami Shibata, Fumihiro Matano, Nobuyuki Saito, Yu Fujiki, Hisashi Matsumoto, Takayuki Mizunari, Akio Morita,
Initial management of severe traumatic brain injury is important and includes treatment decision-making and prediction of prognosis. We examined whether biomarkers at admission could be useful prognostic predictors. We focused on electrolytes and blood glucose, which can be measured easily at any facility and for which results can be obtained promptly, before those of other biomarkers, such as D-dimer.All trauma patients with head injuries treated at Chiba Hokusoh Hospital between 2014 and 2017 ...
Tópico(s): Cardiac Arrest and Resuscitation
2020 - Medknow | Journal of Nippon Medical School
Chie Tanaka, Takashi Tagami, Fumihiko Nakayama, Saori Kudo, Akiko Takehara, Reo Fukuda, Junya Kaneko, Yoshito Ishiki, Shin Sato, Ami Shibata, Masamune Kuno, Kyoko Unemoto, Masayuki Hojo, Tetsuya Mizoue, Yusuke Asai, Setsuko Suzuki, Norio Ohmagari,
Only a few studies have reported the association between age and mortality in COVID-19 patients who require invasive mechanical ventilation (IMV). We aimed to evaluate the effect of age on COVID-19-related mortality among patients undergoing IMV therapy.This cohort study was conducted using the COVID-19 Registry Japan database, a nationwide multi-centre study of hospitalized patients with laboratory-confirmed COVID-19. Of all 33,808 cases registered between 1 January 2020 to 28 February 2021, we ...
Tópico(s): Long-Term Effects of COVID-19
2021 - Springer Nature | Annals of Intensive Care
Junya Kaneko, Takashi Tagami, Kyoko Unemoto, Chie Tanaka, Kentaro Kuwamoto, Shin Sato, Shosei Tani, Ami Shibata, Saori Kudo, Akiko Kitahashi, Hiroyuki Yokota,
Little is known regarding functional outcome following poor-grade (World Federation of Neurosurgical Societies grades IV and V) aneurysmal subarachnoid hemorrhage (aSAH), especially in individuals treated aggressively in the early phase after ictus.We provided patients with aSAH with ultra-early definitive treatment, coiling or clipping, within 6 hours from arrival as per protocol. We classified the patients into 3 groups according to their computed tomography findings: Group 1, intraventricular hemorrhage ...
Tópico(s): Cerebrospinal fluid and hydrocephalus
2019 - Medknow | Journal of Nippon Medical School
TATSUHIKO IGARASHI, Riri Shibata, Futoshi Hasebe, Yasushi Ami, Katsuaki Shinohara, Toshihiko Komatsu, Christiane Stahl‐Hennig, Harald Petry, Gerhard Hunsmann, Takeo Kuwata, Minghao Jin, Akio Adachi, Takashi Kurimura, MINEYUKI OKADA, Tomoyuki Miura, Masanori Hayami,
A chimeric human and simian immunodeficiency virus carrying the tat, rev, vpu, env, and nef genes of human immunodeficiency virus type 1 was generated. The chimeric virus, NM-3n, grew competently in peripheral blood mononuclear cells from cynomolgus monkeys like the parental SIVmac. Two cynomolgus monkeys and one rhesus monkey inoculated with NM-3n raised antibodies to SIVmac Gag and HIV-1 Env. The antibodies raised in the cynomolgus monkeys persisted for at least 1.7 years. The antibodies contained ...
Tópico(s): Herpesvirus Infections and Treatments
1994 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
Frank D. Kolodgie, Renu Virmani, Aloke V. Finn, Maria Romero,
... role of CE.In this issue of Circulation, Shibata et al4 report on 1776 consecutive cases of new-onset AMI between 2001 and 2013 that were screened for ... of microvessels involved with AF-associated thromboembolism in AMI in the study by Shibata et al showed involvement of distal epicardial arteries ...
Tópico(s): Cardiac Arrhythmias and Treatments
2015 - Lippincott Williams & Wilkins | Circulation
E. Ito, Shinsuke Inuki, Yoshihiro Izumi, Masatomo Takahashi, Yuki Dambayashi, Lisa Ciacchi, Wael Awad, Ami Takeyama, Kensuke Shibata, Shotaro Mori, Jeffrey Y. W. Mak, David P. Fairlie, Takeshi Bamba, Eri Ishikawa, Masamichi Nagae, Jamie Rossjohn, Sho Yamasaki,
Mucosal-associated invariant T (MAIT) cells are innate-like T cells that recognize bacterial riboflavin–based metabolites as activating antigens. Although MAIT cells are found in tissues, it is unknown whether any host tissue–derived antigens exist. Here, we report that a sulfated bile acid, cholic acid 7-sulfate (CA7S), binds the nonclassical MHC class I protein MR1 and is recognized by MAIT cells. CA7S is a host-derived metabolite whose levels were reduced by more than 98% in germ-free mice. Deletion ...
Tópico(s): T-cell and B-cell Immunology
2024 - American Association for the Advancement of Science | Science Immunology
Kazunobu Ichikawa, Tsuneo Konta, Mitsuru Emi, Sayumi Toriyama, Satoshi Takasaki, Ami Ikeda, Yoko Shibata, Noriaki Takabatake, Yasuchika Takeishi, Takeo Kato, Sumio Kawata, Isao Kubota,
Paraoxonase-1 (PON1) is an HDL cholesterol–associated antioxidant enzyme, and some of its polymorphisms are linked with systemic oxidative stress and cardiovascular events. In this study, we genotyped seven single nucleotide polymorphisms (SNPs) within the PON1 gene and determined their association with chronic kidney disease in 2,968 individuals from the general Japanese population. We found that a missense SNP (rs662) with a G-to-A substitution leading to an amino acid substitution (G[Arg]/A[Gln]), ...
Tópico(s): Apelin-related biomedical research
2009 - Elsevier BV | Kidney International
Hiroshi Abiko, Tsuneo Konta, Zhimei Hao, Satoshi Takasaki, Kazuko Suzuki, Kazunobu Ichikawa, Ami Ikeda, Yoko Shibata, Yasuchika Takeishi, Sumio Kawata, Takeo Kato, Isao Kubota,
Tópico(s): Hormonal Regulation and Hypertension
2008 - Springer Science+Business Media | Clinical and Experimental Nephrology
Fumihiro Matano, Yasuo Murai, Takayuki Mizunari, Masahiro Yamaguchi, Toshimasa Yamada, Eiichi Baba, Ami Shibata, Tomonori Tamaki, Akio Morita,
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2019 - Springer Science+Business Media | Neurosurgical Review
Junya Kaneko, Takashi Tagami, Chie Tanaka, Kentaro Kuwamoto, Shin Sato, Ami Shibata, Saori Kudo, Akiko Kitahashi, Masamune Kuno, Shoji Yokobori, Kyoko Unemoto,
Rebleeding of aneurysmal subarachnoid hemorrhage (aSAH) is one of the significant risk factors for poor clinical outcome. The rebleeding risk is the highest during the acute phase with an approximate rebleeding rate of 9-17% within the first 24 h. Theoretically, general anesthesia can stabilize a patient's vital signs; however, its effectiveness as initial management for preventing post-aSAH rebleeding remains unclear. The purpose of this study was to determine the feasibility and safety of ultra- ...
Tópico(s): Neurosurgical Procedures and Complications
2021 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Kosuke Kudo, Tsuneo Konta, Yusuke Mashima, Kazunobu Ichikawa, Satoshi Takasaki, Ami Ikeda, Masato Hoshikawa, Kazuko Suzuki, Yoko Shibata, Tetsu Watanabe, Takeo Kato, Sumio Kawata, Isao Kubota,
Tópico(s): Acute Kidney Injury Research
2011 - Springer Science+Business Media | Clinical and Experimental Nephrology
Tsuneo Konta, Kosuke Kudo, Hiroko Sato, Kazunobu Ichikawa, Ami Ikeda, Kazuko Suzuki, Atsushi Hirayama, Yoko Shibata, Tetsu Watanabe, Makoto Daimon, Takeo Kato, Yoshiyuki Ueno, Takamasa Kayama, Isao Kubota,
Tópico(s): Dialysis and Renal Disease Management
2013 - Springer Science+Business Media | Clinical and Experimental Nephrology
Yosuke Ando, Takahiro Hayashi, Kaori Ito, Eri Suzuki, Naoyuki Mine, Ayumi Miyamoto, Miyuki Oya, H Matsuda, Ami Isaji, Toru Nakanishi, Kazuyoshi Imaizumi, Tomoyuki Shibata, Tatsuyoshi Okada, Kazuo Sakurai, Kensei Naito, Ichiro Uyama, Kenji Kawada, Hiroshi Takahashi, Shigeki Yamada,
We aimed to compare the preventive effect of 5-day administration of aprepitant with single administration of fosaprepitant meglumine against nausea and vomiting symptoms due to highly emetogenic chemotherapy regimens comprising cisplatin (CDDP).Subjects were inpatients who underwent chemotherapy for gastric cancer, esophageal cancer, lung cancer, or head and neck cancer with a regimen comprising 60 mg/m(2) or higher dose of CDDP. In this randomised, open-label, controlled study, the subjects were ...
Tópico(s): Anesthesia and Pain Management
2015 - Springer Science+Business Media | Supportive Care in Cancer
Tsuneo Konta, Mitsuru Emi, Sayumi Toriyama, Hideto Ariumi, Miho Ishii, Satoshi Takasaki, Ami Ikeda, Kazunobu Ichikawa, Yoko Shibata, Noriaki Takabatake, Yasuchika Takeishi, Takeo Kato, Sumio Kawata, Isao Kubota,
Tópico(s): Genetic Associations and Epidemiology
2008 - Springer Nature | Journal of Human Genetics
Mizue Ishikawa, Tsuneo Konta, Zhimei Hao, Satoshi Takasaki, Hiroshi Abiko, Toshiyuki Takahashi, Ami Ikeda, Kazunobu Ichikawa, Yoko Shibata, Yasuchika Takeishi, Takeo Kato, Sumio Kawata, Isao Kubota,
Tópico(s): Renal and Vascular Pathologies
2008 - Springer Science+Business Media | Clinical and Experimental Nephrology
Kazuma Sasaki, Takashi Tagami, Hirofumi Obinata, Chie Tanaka, Kosuke Otake, Yudai Yoshino, Akihiro Watanabe, Ami Shibata, Kentaro Kuwamoto, Junichi Inoue, Shoji Yokobori,
Tópico(s): Emergency and Acute Care Studies
2025 - BioMed Central | Critical Care
Ami Shibata, Fumihiro Matano, Yu Fujiki, Takayuki Mizunari, Yasuo Murai, Hiroyuki Yokota, Akio Morita,
The efficacy of thyrotropin-releasing hormone tartrate (TRH-T) for treating prolonged disturbance of consciousness due to aneurysmal subarachnoid hemorrhage (SAH) remains unclear. The purpose of the present study was to determine whether TRH-T was really effective, and what was the recovery factor when it was valid. This was a retrospective study of a single facility.We treated 208 patients with aneurysmal SAH at our hospital between 2011 and 2017. Among them, we investigated 97 cases in which TRH- ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2019 - Elsevier BV | Journal of Stroke and Cerebrovascular Diseases
Tatsuhiko Igarashi, Yasushi Ami, Takeo Kuwata, M. Hayami, K. Shinohara, Akio Adachi, Riri Shibata, Hiroshi Yamamoto, Toshihiko Komatsu, R Mukai,
Two simian immunodeficiency virus strain mac (SIVmac)/human immunodeficiency virus type 1(HIV-1) chimeric viruses (SHIVs), designated NM-3 and NM-3n, with env derived from HIV-1 and defective vpr (plus defective nef for NM-3), were inoculated into seven macaques. These macaques were transiently or persistently infected and most of them produced long-lasting neutralizing antibodies and Env-specific killer T cells to HIV-1 with no AIDS-like symptoms. When they were challenged with another SHIV with intact ...
Tópico(s): HIV/AIDS Research and Interventions
1997 - Microbiology Society | Journal of General Virology
Kazuko Suzuki, Tsuneo Konta, Satoshi Takasaki, Ami Ikeda, Kazunobu Ichikawa, Hitoshi Sato, Yoko Shibata, Tetsu Watanabe, Takeo Kato, Sumio Kawata, Isao Kubota,
Tópico(s): Sodium Intake and Health
2009 - Springer Science+Business Media | Clinical and Experimental Nephrology
Ami Ikeda, Tsuneo Konta, Satoshi Takasaki, Zhimei Hao, Kazuko Suzuki, Hiroko Sato, Yoko Shibata, Yasuchika Takeishi, Takeo Kato, Satoshi Kawata, I. Kubota,
Glomerular and tubular damage are important factors in the development of renal insufficiency. However, the interaction of these factors is largely unknown in the non-diabetic Japanese population. To clarify the relationship between renal insufficiency and both glomerular and tubular damage, we conducted a community-based study using albuminuria and urine beta 2-microglobulin as markers of glomerular and tubular damages, respectively.Subjects of this study were 2816 non-diabetic individuals >40 years ...
Tópico(s): Blood Pressure and Hypertension Studies
2008 - Oxford University Press | Nephrology Dialysis Transplantation
Yuki Tamaki, Yuria Shibata, Misaki Hayakawa, Nodoka Kato, Ami Machii, Yuma Ikeda, Eri Nanizawa, Yumi Hayashi, Hiroshi Suemizu, Hiroyasu Ito, Tetsuya Ishikawa,
Cell-based transplantation therapy using hepatocytes, hepatic stem cells, hepatocyte-like cells induced from stem cells, etc. is thought to be an attractive alternative to liver transplantation, and have been studied to date. For its clinical application, however, it is extremely important to develop a model that reproduces the pathological conditions with indication for treatment and enables the study for the ideal treatment strategy.The transgenic mice which express the thymidine kinase (TK) gene ...
Tópico(s): Liver Disease Diagnosis and Treatment
2022 - Elsevier BV | Biochemistry and Biophysics Reports
Takashi Otani, Ami Tsuyuki, Taiki Iwachi, Satoshi Someya, Kotaro Tateno, Hidetoshi Kawai, Takao Saito, Kyalo Stephen Kanyiva, Takanori Shibata,
Abstract A facile two‐step synthesis of aza[7]helicenes possessing a 6‐5‐6‐6‐6‐5‐6 skeleton from commercially available 2,9‐dichloro‐1,10‐phenanthroline via double amination with aniline derivatives followed by hypervalent iodine reagent‐mediated intramolecular double‐NH/CH couplings was developed. Single‐crystal X‐ray analyses of the helicenes revealed unique structures, including both a significantly twisted center and planar terminals of the skeleton. The azahelicenes show high fluorescent quantum ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2017 - Wiley | Angewandte Chemie
Takashi Otani, Ami Tsuyuki, Taiki Iwachi, Satoshi Someya, Kotaro Tateno, Hidetoshi Kawai, Takao Saito, Kyalo Stephen Kanyiva, Takanori Shibata,
Abstract A facile two‐step synthesis of aza[7]helicenes possessing a 6‐5‐6‐6‐6‐5‐6 skeleton from commercially available 2,9‐dichloro‐1,10‐phenanthroline via double amination with aniline derivatives followed by hypervalent iodine reagent‐mediated intramolecular double‐NH/CH couplings was developed. Single‐crystal X‐ray analyses of the helicenes revealed unique structures, including both a significantly twisted center and planar terminals of the skeleton. The azahelicenes show high fluorescent quantum ...
Tópico(s): Porphyrin and Phthalocyanine Chemistry
2017 - Wiley | Angewandte Chemie International Edition
Tsuneo Konta, Satoshi Takasaki, Kazunobu Ichikawa, Mitsuru Emi, Sayumi Toriyama, Hitoshi Satoh, Ami Ikeda, Kazuko Suzuki, Yusuke Mashima, Yoko Shibata, Tetsu Watanabe, Takeo Kato, Sumio Kawata, Isao Kubota,
Nephronophthisis (NPHP) 4 gene coding nephrocystin-4 is involved in the development of renal tubules and its congenital mutations cause juvenile end-stage renal disease, NPHP. To investigate the association between single-point single-nucleotide polymorphism (SNP) of NPHP4 gene and renal function, we conducted a cross-sectional study in Japanese population. The subjects of this study were non-diabetic general population consisting of 2604 individuals >40 years in Takahata town, Japan. We genotyped ...
Tópico(s): Biomedical Research and Pathophysiology
2010 - Springer Nature | Journal of Human Genetics
Y. Mashima, Tsuneo Konta, Kyousuke Kudo, Kazuko Suzuki, Ami Ikeda, Kunio Ichikawa, Yohei Shibata, Tadashi Watanabe, Gen Tamiya, Takeo Kato, Satoshi Kawata, I. Kubota,
Background. A cluster of proinflammatory cytokines plays an important role in the development of various renal diseases, and the expression of these cytokines is genetically modified. To examine the association between polymorphisms of proinflammatory cytokine genes and albuminuria, a cross-sectional study was conducted in the general population.
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Oxford University Press | Nephrology Dialysis Transplantation
Ryota Ushio, Masaki Yamamoto, Atsushi Miyasaka, Tatsuya Muraoka, Hiromi Kanaoka, Hironori Tamura, Ayami Kaneko, Ami Izawa, Nobuyuki Hirama, Shuhei Teranishi, Saki Manabe, Tatsuya Inoue, Kunihiko Shibata, Yasuyuki Sugiura, Makoto Kudo, Takeshi Kaneko,
A 58-year-old man was diagnosed with lung adenocarcinoma with a tumor proportion score of 10%. After six cycles of second-line chemotherapy with nivolumab, he achieved a complete response (CR) but developed uveitis and sensorineural hearing disorder, which were consistent with Vogt-Koyanagi-Harada (VKH)-like syndrome. Simultaneously, pituitary adrenocortical insufficiency was identified. Nivolumab discontinuation and systemic corticosteroid administration resolved these immune-related adverse events ( ...
Tópico(s): Myasthenia Gravis and Thymoma
2021 - The Japanese Society of Internal Medicine | Internal Medicine
Chizumi Yamada, Shimpei Fujimoto, Kaori Ikeda, Yuki Nomura, Ami Matsubara, Miwako Kanno, Kenichiro Shide, Kiyoshi Tanaka, Eri Imai, Tsutomu Fukuwatari, Katsumi Shibata, Nobuya Inagaki,
Aims/Introduction: To estimate nutritional risk factors for osteoporosis in patients with type 2 diabetes, bone mineral density, homocysteine level, and intakes and levels of Hcy-related vitamins including folate, vitamin B6 and vitamin B12 were analyzed in a cross-sectional study. Lumbar spine and femoral neck bone mineral density, serum concentrations of vitamin B6, vitamin B12, and folate and plasma homocysteine levels were measured in 125 Japanese patients with type 2 diabetes. Nutrient intake ...
Tópico(s): Nutrition and Health in Aging
2010 - Asian Association for the Study of Diabetes | Journal of Diabetes Investigation
Junya Kaneko, Ami Shibata, Akiko Kitahashi, Saori Kudo, Kyoko Unemoto, Hidenori Yamaguchi, Michio Yamazaki, Tomonori Tamaki, Gaku Matsumoto, Hiroyuki Yokota, Akio Hyodo,
Objective: Dural arteriovenous fistulae at craniocervical junction (CCJ dAVF) cause subarachnoid hemorrhage (SAH). We present a case of CCJ dAVF with SAH in which endovascular treatment was initially performed, followed by surgical management, leading to radical cure.
Tópico(s): Meningioma and schwannoma management
2017 - | Journal of Neuroendovascular Therapy
Kosuke Otake, Takashi Tagami, Chie Tanaka, Yudai Yoshino, Akihiro Watanabe, Ami Shibata, Kentaro Kuwamoto, Junichi Inoue, Shoji Yokobori,
Tópico(s): Pregnancy-related medical research
2024 - Elsevier BV | Journal of Vascular and Interventional Radiology