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... Advertising Items Cheyne Altwood Multiple Classified Advertising Items ANCA Citroen Huge Savings A Collectors Dream Superb Daimler ...
1994 - Gale Group | Sunday Times HA GDA
... a rethinkWas sind die Indikationen für Rescue-Verfahren?ANCA-assoziierte VaskulitidenCase 39-2018: An 18-Year-Old ... Proptosis of the Left EyePathogenesis and treatment of ANCA-associated vasculitis—a role for complementClinical trials in ... Society of Rheumatology for the induction therapy of ANCA-associated vasculitisOrbital inflammatory disease managementAirway Involvement in Granulomatosis ... Man With Dyspnea and HemoptysisRituximab Versus Cyclophosphamide for ANCA-Associated Vasculitis with Renal InvolvementRheumatologic ConditionsImmunologic Nonasthmatic Diseases ...
Tópico(s): Sarcoidosis and Beryllium Toxicity Research
1967 - American College of Physicians | Annals of Internal Medicine
S. J. MacKie, Prof. E. Suess, J. W. Kirkby, Edward Hull, Rev. H. B. Tristram, J. F. Whiteaves, Rev. Wm. Lister, W. Pengelly, Dr. Thomas Wright, Baron Anca De Mangalviti, Rev. W. S. Symonds, Rev. J. Dingle, J. A. Knipe, Charles Moore, Professor D. T. Ansted,
Frontmatter: The Geologist. Essay: On the Avicula Contorta Beds, and Lower Lias of the South of England, Summary of Paper on the Geological System of ...
1860 - Gale Group | NCCO-STM 1of2
Victor E. Pollak, Nina Mendoza,
Antineutrophil cytoplasmic antibodies (ANCA) are important serological markersfor the primary systemic vasculitides, including microscopic polyarteritis and necrotizing crescentic glomerulonephritis. Numerous reports have established the clinical utility of ANCA titer in monitoring disease activity, relapses, and response to treatment. ANCA, detected by indirect immunofluorescence (IIF) assays using patient' ... produce two common fluorescent staining patterns: cytoplasmic (C-ANCA), involving a 29-kD neutral serine protease termed ...
Tópico(s): Urticaria and Related Conditions
1971 - Elsevier BV | Medical Clinics of North America
Ronald J. Falk, Regina S. Terrell, L Charles, J. Charles Jennette,
Anti-neutrophil cytoplasmic autoantibodies (ANCA) are in the circulation of most patients with pauci-immune necrotizing vasculitis and pauci-immune crescentic glomerulonephritis. The current study ... of these autoantibodies on neutrophil function in vitro. ANCA cause normal human neutrophils to undergo an oxidative burst and degranulate. Both ANCA phenotypes (i.e., cytoplasmic-pattern ANCA and myeloperoxidase-specific ANCA) induce neutrophil activation. ANCA sera and purified immunoglobulins significantly increase the release ...
Tópico(s): Autoimmune and Inflammatory Disorders
1990 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Michael Venning, A. Quinn, V Broomhead, A. Graham Bird,
... were examined for antibodies to neutrophil cytoplasmic antigen (ANCA). An indirect immunofluorescence assay on ethanol fixed human neutrophils identified two types of autoantibody: C-ANCA, which produces diffuse cytoplasmic staining and P-ANCA, which produces an artefactual nuclear/perinuclear staining pattern. The diagnosis of patients in whom ANCA of either form was found was established following ... Forty of 45 patients whose sera contained C-ANCA at a titre of > 1/40 satisfied the ... microscopic polyarteritis. Twelve of 30 patients with P-ANCA at a titre of >1/40 were also ...
Tópico(s): Cell Adhesion Molecules Research
1990 - Oxford University Press | QJM
Jukka Mustonen, Esa Soppi, Amos Pasternack, Olavi H auml llstr ouml m,
The diagnostic significance of anticytoplasmic autoantibodies (ANCA) was studied in 71 renal patients. The ANCA test was positive in 67% of patients with Wegener's granulomatosis (WG), in 35% ... associated with unspecific collagenosis/vasculitis. Among WG patients ANCA positivity clearly correlated with the presence of active renal disease. Interestingly, both ANCA-positive and -negative patients were encountered in the ... infiltrates. The diagnostic and clinical significance of the ANCA test in these cases remains for the present ...
Tópico(s): Renal Diseases and Glomerulopathies
1990 - Karger Publishers | American Journal of Nephrology
Linda Charles, Ronald J. Falk, J. Charles Jennette,
Anti-neutrophil cytoplasmic autoantibodies (ANCA) react with antigens in the cytoplasm of neutrophils and monocytes, and are found in the blood of patients with necrotizing ... necrotizing and crescentic glomerulonephritis. The standard techniques for ANCA analysis use human polymorphonuclear leukocytes (PMN) as a source for antigen. A comparison was made between ANCA reactivity with human PMN and HL-60 cells. Fifty-five ANCA-positive and 17 ANCA-negative sera were reacted with HL-60 cells ... reactivity and between the two major types of ANCA. The HL-60 cell method agreed with a ...
Tópico(s): Cell Adhesion Molecules Research
1989 - Academic Press | Clinical Immunology and Immunopathology
Roel Goldschmeding, C. Ellen van der Schoot, Daan ten Bokkel Huinink, C. Erik Hack, M. E. van den Ende, C. G. M. Kallenberg, A E von dem Borne,
Anti-neutrophil cytoplasmic autoantibodies (ANCA) specifically associated with Wegener's granulomatosis were found to be directed against a saline-soluble glycoprotein triplet that migrates on ... was specifically recognized by all cytoplasmic-staining (C)-ANCA-positive sera from patients with Wegener's disease. C-ANCA antigen bound [3H]diisopropylfluorophosphate, which indicates that it ... treated neutrophils with FMLP induced release of C-ANCA antigen. This indicates that in vivo C-ANCA might interact with the C-ANCA antigen after ...
Tópico(s): Systemic Lupus Erythematosus Research
1989 - American Society for Clinical Investigation | Journal of Clinical Investigation
José A. Gómez‐Puerta, Xavier Bosch,
... to medium-sized vessels are commonly known as ANCA-associated vasculitis (AAV) and include Wegener's granulomatosis, ... trigger cross-reactive autoimmunity to a previously characterized ANCA antigen, lysosomal membrane protein-2, which is contained ... to medium-sized vessels are commonly known as ANCA-associated vasculitis (AAV) and include Wegener's granulomatosis, ... trigger cross-reactive autoimmunity to a previously characterized ANCA antigen, lysosomal membrane protein-2, which is contained ... as the major autoantigen accounting for the cytoplasmic ANCA pattern of WG.4Jenne DE Tschopp J Ludemann ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2009 - Elsevier BV | American Journal Of Pathology
Akiko Uehara, Tadasu Sato, Atsushi Iwashiro, S. Yokota,
Anti-neutrophil cytoplasmic antibodies (ANCA) is autoantibodies characteristic of vasculitis diseases. A connection between ANCA and Wegener's granulomatosis was well established. The interaction of both ANCA phenotypes (PR3-ANCA and MPO-ANCA) with leukocytes provoked cell activation, which might be involved in the pathogenesis of ANCA-related Wegener's granulomatosis.In this study, we examined whether PR3-ANCA sera and purified immunoglobulins from patients with Wegener' ... necrosis factor-alpha. On the other hand, PR3-ANCA-negative sera from patients with polyarteritis nodosa which ...
Tópico(s): Immune Response and Inflammation
2009 - BioMed Central | Diagnostic Pathology
Samih H. Nasr, Samar M. Said, Anthony M. Valeri, Michael B. Stokes, Naveed Masani, Vivette D. D’Agati, Glen S. Markowitz,
... concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been ... pathologic findings in 14 patients with MGN and ANCA-associated NCGN.The cohort consisted of eight men ... with a mean age of 58.7 yr. ANCA positivity was documented by indirect immunofluorescence or ELISA ... immunofluorescence was positive in 13 patients (seven P-ANCA, five C-ANCA, one atypical ANCA). ELISA was positive in nine of 10 patients ( ...
Tópico(s): Autoimmune Bullous Skin Diseases
2009 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
José A. Gómez‐Puerta, José Hernández‐Rodríguez, Alfonso López‐Soto, Xavier Bosch,
... medium-sized vessels that are commonly recognized as ANCA-associated vasculitis, which includes necrotizing granulomatous vasculitis (NGV) [ ... progresses to systemic disease with proteinase 3 (PR3)-ANCA-associated vasculitis, suggesting an aberrant cell-mediated immune ... may represent lymphoid structures ultimately responsible for PR3-ANCA production. In both NGV and MPA, necrotizing glomerulonephritis ... may well result from an injury orchestrated by ANCA. Untreated NGV and MPA normally are rapidly progressive ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Elsevier BV | CHEST Journal
Feng Yu, Ying Tan, Gang Liu, Suxia Wang, Wan-zhong Zou, Ming‐Hui Zhao,
... frequency of positive serum anti-neutrophil cytoplasmic antibody (ANCA) were each significantly higher, whereas complete remission rates ... term outcome was poor. The precise role of ANCA in the pathologic course of crescentic lupus nephritis ... frequency of positive serum anti-neutrophil cytoplasmic antibody (ANCA) were each significantly higher, whereas complete remission rates ... term outcome was poor. The precise role of ANCA in the pathologic course of crescentic lupus nephritis ... crescentic glomerulonephritis group were anti-neutrophil cytoplasmic antibodies (ANCA)-positive, including nine with p-ANCA and one ...
Tópico(s): Renal Diseases and Glomerulopathies
2009 - Elsevier BV | Kidney International
Rubal Patel, Sagar Naik, Alexey Amchentsev, Anthony Saleh,
... IU/mL), respectively. Cytoplasmic-staining antineutrophil cytoplasmic antibody (ANCA) and perinuclear-staining ANCA levels were < 6 units/mL. Aspergillus titers and ... nonnecrotizing granulomas with morphology typical of sarcoidosis. Serum ANCA levels were normal, and the patient did not ... IU/mL), respectively. Cytoplasmic-staining antineutrophil cytoplasmic antibody (ANCA) and perinuclear-staining ANCA levels were < 6 units/mL. Aspergillus titers and ... nonnecrotizing granulomas with morphology typical of sarcoidosis. Serum ANCA levels were normal, and the patient did not ...
Tópico(s): Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
2009 - Elsevier BV | CHEST Journal
... clinical observations suggests that anti-neutrophil cytoplasmic antibodies (ANCA) play a critical role in the vascular damage of ANCA-associated vasculitis (AAV).1 Understanding the key pathogenic ... rational therapeutic approach. Although the pathogenic role of ANCA in AAV has been studied extensively, it is ... triggers cross-reactive autoimmunity to a previously characterized ANCA antigen, lysosomal membrane protein 2 (LAMP-2), resulting ... were infected with the Ross River virus. Several ANCA autoantigens are leukocyte proteins implicated in host defense ...
Tópico(s): Inflammasome and immune disorders
2009 - American Society of Nephrology | Journal of the American Society of Nephrology
Renato Alberto Sinico, Paolo Bottero,
... classified among the so-called anti-neutrophil antibody (ANCA)-associated systemic vasculitides (AASVs) because of its clinical ... present in only 38% of patients. Moreover, the ANCA status was shown to segregate with clinical phenotype. ANCA-positive patients were significantly more likely to have ... vasculitis, including necrotising glomerulonephritis, mononeuritis and purpura, whereas ANCA-negative cases were significantly more likely to have ... was documented less frequently in histological specimens from ANCA-negative patients in comparison with ANCA-positive ones. ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Elsevier BV | Best Practice & Research Clinical Rheumatology
Hidehiro Tabata, Kazuho Honda, Takahito Moriyama, Mitsuyo Itabashi, Sekiko Taneda, Takashi Takei, Kazunari Tanabe, Satoshi Teraoka, Yutaka Yamaguchi, Hideaki Oda, Kosaku Nitta,
Two cases of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (ANCA-V) occurred in the transplanted kidney were reported. Case 1 was a 57 yr-old female whose original disease was MPO-ANCA-V. A relapse of necrotizing crescentic glomerulonephritis occurred ... after transplantation with positive serum reaction for MPO-ANCA. In spite of several immunosuppressive treatments, the disease ... after transplantation with positive serum reaction for MPO-ANCA. She returned to hemodialysis treatment five yr after ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Wiley | Clinical Transplantation
Elena Csernok, Peter Lamprecht, Wolfgang L. Gross,
Drugs and infections may induce antineutrophil cytoplasmic antibodies (ANCA) and vasculitic manifestations mimicking ANCA-associated vasculitides (AAV) and mechanisms relevant in their ... Drug-induced and infection-induced proteinase 3 (PR3)-ANCA and myeloperoxidase (MPO)-ANCA may be associated with a vasculitis clinically resembling ... for the break of tolerance and induction of ANCA (e.g. danger signals, superantigens, neutrophil extracellular traps, ... some extent between drug-induced and infection-induced ANCA-positive vasculitis and AAV, especially with regard to ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2009 - Lippincott Williams & Wilkins | Current Opinion in Rheumatology
Jan Damoiseaux, Ulf Steller, Michael Buschtez, Mia Vaessen, Anke Rosemann, Pieter van Paassen, W. Stöcker, Kaï Fechner, Jan Willem Cohen Tervaert,
The consensus on anti-neutrophil cytoplasmic antibody (ANCA) testing requires screening with indirect immunofluorescence (IIF) and confirmation in MPO- and PR3-ANCA specific assays. The EUROPLUS™ system combines in one incubation ... the diagnostic applicability of this new system for ANCA-associated vasculitis (AAV). To assess the diagnostic performance ... and capture ELISAs for both MPO- and PR3-ANCA. Based on the reference multi-testing algorithm 123 AAV patients were defined as having PR3-ANCA and 68 AAV patients as having MPO-ANCA ( ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Elsevier BV | Journal of Immunological Methods
Adrian Schreiber, Susanne Rolle, Ludmilla Peripelittchenko, Jörg Rademann, Wolfgang Schneider, Friedrich C. Luft, Ralph Kettritz,
Antineutrophil cytoplasmic autoantibodies (ANCA) are associated with necrotizing crescentic glomerulonephritis (NCGN) and systemic vasculitis. We examined the role of phosphoinositol 3 kinase-γ isoform (PI3Kγ) in ANCA-activated neutrophil functions. Further, we tested whether its inhibition protects a mouse model of ANCA NCGN from developing NCGN. We transplanted bone marrow ... model. AS605240 significantly abrogated myeloperoxidase- or proteinase 3-ANCA-stimulated superoxide production in vitro. Furthermore, ANCA-induced ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Elsevier BV | Kidney International
Wei Lin, Min Chen, Ming‐Hui Zhao,
Antineutrophil cytoplasmic antibodies (ANCA) are important serologic markers for ANCA-associated vasculitis (AAV). Our previous studies in propylthiouracil (PTU)-induced AAV demonstrated that ... decrease of avidity of PTU-induced myeloperoxidase (MPO)-ANCA. This study investigated the changes in avidity and titer of MPO-ANCA in sequential sera from some patients with primary ... Sequential sera samples of seven patients with MPO-ANCA-positive vasculitis at their initial onset, remission and relapse were collected. The avidity of MPO-ANCA was assessed by antigen-inhibition enzyme-linked immunosorbent ...
Tópico(s): Sarcoidosis and Beryllium Toxicity Research
2009 - Informa | Autoimmunity
Christos Bantis, Μaria Stangou, Christoph Schlaugat, Efstathios Alexopoulos, Aphroditi Pantzaki, Dimitrios Memmos, Katrin Ivens, Peter Heering,
... for ANCAs, compared with only one-third of ANCA-negative patients, presented with the clinical syndrome of rapid progressive glomerulonephritis. ANCA-positive patients reached a higher peak serum creatinine ... 9 ± 30.1 mL/min/1.73 m2). ANCA-positive patients with IgA nephropathy had a higher ... of crescentic glomeruli (54.3% ± 18%) compared with ANCA-negative patients with crescentic IgA nephropathy (34.5% ± 26%). ANCA-positive patients were treated using cyclophosphamide and corticosteroids. ... In contrast, no significant improvement was achieved in ANCA-negative patients. Conclusion Patients with IgA nephropathy, crescents, ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2009 - Elsevier BV | American Journal of Kidney Diseases
Yusuke Suzuki, Yukihiko Takeda, Daisuke Sato, Yasuhiko Kanaguchi, Yuichi Tanaka, S Kobayashi, Kazuo Suzuki, Hiroshi Hashimoto, Shoichi Ozaki, Satoshi Horikoshi, Yasuhiko Tomino,
Antineutrophil cytoplasmic antibody (ANCA)-associated small-vessel vasculitides are major causes of rapidly progressive glomerulonephritis (RPGN). Although recent papers suggest differences in clinicoepidemiological manifestations of ANCA-associated vasculitis between Japan [microscopic polyangiitis (MPA) ≫ Wegener’ ... more than 1 year, concerning the incidence of ANCA-related vasculitis, the presence of (MPO)/proteinase 3 (PR3)-ANCA and their clinical outcomes. As there were no PR3-ANCA single positive and/or WG patients, all patients ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2009 - Oxford University Press | Modern Rheumatology
De Riva Valentina, Celadin Marilena, Pittoni Marina, Mario Plebani, Paolo Angeli,
ABSTRACT Background: Anti‐neutrophil cytoplasm antibodies (ANCA) have been detected in serum from patients affected by autoimmune CLD, and to a lesser extent, in serum of patients affected by non autoimmune CLD. The clinical significance of ANCA in these disorders is still unclear. Aims: To explore the clinical and diagnostic significance of ANCA in CLD. Materials and methods: Forty‐five sera ... and ELISA. Results: A low correspondence between the ANCA positivity obtained by IFI and ELISA was observed. ...
Tópico(s): Systemic Lupus Erythematosus Research
2009 - Wiley | Liver International
Mária Papp, I Altorjay, Gabriella Lakos, Judit Tumpek, Sándor Sipka, Tamás Dinya, Károly Palatka, Gábor Veres, M. Udvardy, Péter L. Lakatos,
... IIF) detection and interpretation of antineutrophil cytoplasmic antibodies (ANCA) have been proposed for inflammatory bowel diseases (IBD). ... formalin-fixed neutrophil substrates to identify atypical perinuclear ANCA (P-ANCA) by IIF under routine laboratory circumstances. A total ... and formalin-fixed slides to detect atypical P-ANCA resulted in a lack of agreement between assays ( ... kappa, 0.42). After atypical and typical P-ANCA patterns were combined, the consensus improved greatly. A total of 26.9% of patients were P-ANCA positive by at least two tests (44.3% ...
Tópico(s): Renal Diseases and Glomerulopathies
2009 - American Society for Microbiology | Clinical and Vaccine Immunology
Jan C. Drooger, A Dees, A. J. G. Swaak,
... the data of all patients with a positive ANCA test between 1995 and 2005 at our hospital. ... on serology patients were divided in three subgroups (ANCA-Proteinase 3 (PR3), ANCA-Myeloperoxidase (MPO) and atypical ANCA), irrespective of the diagnosis. Patient survival was compared ... groups of specific ANCAs were determined.Fifty-four ANCA-positive patients were analyzed. Eighteen of these patients were ANCA-PR3-positive, 17 were ANCA-MPO-positive and 19 had a atypical ANCA. A random control group was created of matched ...
Tópico(s): Peripheral Neuropathies and Disorders
2009 - Bentham Science Publishers | The Open Rheumatology Journal
Antineutrophil cytoplasmic autoantibodies (ANCA) are present in patients with systemic vasculitis with or without renal involvement. These antibodies were first seen using indirect ... perinuclear pattern. The cytoplasmic pattern is called C-ANCA (classical or cytoplasmic ANCA) and the perinuclear, P-ANCA. Antibodies to a serine proteinase, called proteinase 3 or myeloblastin, give rise to the C-ANCA pattern, while antibodies to myeloperoxidase give rise to the P-ANCA pattern. Proteinase 3, as well as myeloperoxidase, is ...
Tópico(s): Eosinophilic Disorders and Syndromes
1991 - Elsevier BV | American Journal of Kidney Diseases