Produção Nacional
Revisado por pares
Danielle Brito e Cunha, Ana Frederico, Tamiris Azamor, Juliana Gil Melgaço, Patrícia Neves, A. P. K. P. BOM, Tatiana Martins Tilli, Sotiris Missailidis,
The depth and versatility of siRNA technologies enable their use in disease targets that are undruggable by small molecules or that seek to achieve a refined turn-off of the genes for any therapeutic area. Major extracellular barriers are enzymatic degradation of siRNAs by serum endonucleases and RNAases, renal clearance of the siRNA delivery system, the impermeability of biological membranes for siRNA, activation of the immune system, plasma protein sequestration, and capillary endothelium crossing. ...
Tópico(s): MicroRNA in disease regulation
2022 - Multidisciplinary Digital Publishing Institute | Pharmaceuticals
Produção Nacional
Revisado por pares
Cácio Luiz Boechat, Lizandra de Sousa Luz Duarte, Antonny Francisco Sampaio de Sena, Clístenes Williams Araújo do Nascimento, Ygor Jacques Agra Bezerra da Silva, Yuri Jacques Agra Bezerra da Silva, Ana Clécia Campos Brito, Paloma Cunha Saraiva,
Tópico(s): Radioactivity and Radon Measurements
2020 - Springer Science+Business Media | Environmental Monitoring and Assessment
Produção Nacional
Revisado por pares
Regina C. S. Álvala, Ana Paula Martins do Amaral Cunha, SHEILA S.B. BRITO, Marcelo E. Seluchi, José A. Marengo, Osvaldo L. L. Moraes, M. A. de Carvalho,
Drought is a natural and recurrent phenomenon. It is considered 'a natural disaster' whenever it occurs in an intensive manner in highly populated regions, resulting in significant damage (material and human) and loss (socioeconomic). This paper presents the efforts developed to monitor the impact of drought in the semiarid region of Northeast Brazil. In this scope, information from different sources is compiled to support the evaluation and identification of impacted municipalities, with the main ...
Tópico(s): Geography and Environmental Studies
2017 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Lia Selig, M Belo, Antônio José Lêdo Alves da Cunha, Eleny Guimarães Teixeira, Rossana Brito, Ana Lucia Luna, Anete Trajman,
INTRODUÇÃO:Em 1998, o Rio de Janeiro era o estado de maior incidência e mortalidade por tuberculose do Brasil. O Sistema de Informação de Agravos de Notificação em Tuberculose (SINAN-TB-RJ) não era confiável. OBJETIVO: Utilizar o estudo dos óbitos por tuberculose como instrumento de avaliação do programa de controle de tuberculose. MÉTODO: Foram realizados estudos descritivos do SINAN-TB-RJ e do Sistema de Informação de Mortalidade em tuberculose do Rio de Janeiro (SIM-TB-RJ) e os dois bancos de dados ...
Tópico(s): Data-Driven Disease Surveillance
2004 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Lia Selig, M Belo, Antônio José Lêdo Alves da Cunha, Eleny Guimarães Teixeira, Rossana Brito, Ana Lucia Luna, Anete Trajman,
Tópico(s): Public Health in Brazil
2004 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Produção Nacional
Revisado por pares
Bianca C. Martins, Emilio F. Rodrigues, Ana Letícia Groszewicz de Souza, Denise E. de Almeida, Fábio Luiz da Cunha Brito, Júlio Carlos Canola, Dennis E. Brooks, José Luiz Laus,
Ultrasonography of the lens and posterior segment is an indispensable step in the preoperative evaluation of dogs with cataracts, since ophthalmoscopy is not feasible when there is opacification of the lens. This study evaluated the echographic conditions of cataractous lens and fundus of the eye in dogs affected by cataracts. The study was conducted in 30 dogs (56 eyes), 10 males and 20 females, with different types of cataracts at different stages of development. Echography in A and B modes, simultaneously, ...
Tópico(s): Corneal surgery and disorders
2010 - Colégio Brasileiro de Patologia Animal (CBPA) | Pesquisa Veterinária Brasileira
Ana Figueiredo, Maria Amélia Almeida, Teresa Almodôvar, Paula M. Alves, António Araújo, D. Morchón Araujo, Fernando Barata, Lourdes Barradas, Ana Barroso, U Brito, E. Camacho, Dolores Canário, T Cardoso, A. Chaves, Luís Costa, J. Cunha, J Duarte, F. Estevinho, M. Felizardo, João Paulo S. Fernandes, L. Ferreira, L. Ferreira, Paula Fidalgo, Carolina Saliba de Freitas, P. Garrido, Nuno Gil, Direndra Hasmucrai, Eduarda Eugênia Dias de Jesus, José António Lopes, Joana Martins‐Macedo, A. Meleiro, R. Nêveda, Fábio César Sousa Nogueira, M. Pantorotto, B. Parente, Alice Pêgo, Maria João Rocha, João Roque, Carlos Roberto dos Santos, João Tomé Saraiva, Eike Lawrence Nascimento Soares e Silva, S. Silva, Sérgio Simões, Michellia Pereira Soares, E. Teixeira, T. Timóteo, Venceslau Hespanhol,
The main aim of the study was to evaluate the efficacy and safety profile of Nivolumab, an immune-checkpoint-inhibitor antibody, in advanced, previously treated, Non-Small Cell Lung Cancer (NSCLC) patients, in a real world setting. We performed a retrospective, multicentre data analysis of patients who were included in the Portuguese Nivolumab Expanded Access Program (EAP). Eligibility criteria included histologically or citologically confirmed NSCLC, stage IIIB and IV, evaluable disease, sufficient ...
Tópico(s): Lung Cancer Diagnosis and Treatment
2019 - Elsevier BV | Pulmonology
Produção Nacional
Revisado por pares
Momtchilo Russo, Maria Cássia Mendes-Corrêa, Bruna Bezerra Lins, Victor Kersten, Paulo C. A. Pernambuco Filho, Toni Ricardo Martins, Tânia Regina Tozetto‐Mendoza, Lucy Santos Vilas Boas, Brisa Moreira Gomes, Lívia Mendonça Munhoz Dati, Amaro Nunes Duarte‐Neto, Gustavo Roncoli Reigado, Ana Frederico, Danielle Brito e Cunha, Anderson Vicente de Paula, Josiane Ramos da Silva, Carlos Franciney Moreira Vasconcelos, Felipe S. Chambergo, Viviane Abreu Nunes, Ana Paula Dinis Ano Bom, Leda R. Castilho, Rodrigo A. P. Martins, Mário Hiroyuki Hirata, Luciana Mirotti,
Mucosal vaccination appears to be suitable to protect against SARS-CoV-2 infection. In this study, we tested an intranasal mucosal vaccine candidate for COVID-19 that consisted of a cationic liposome containing a trimeric SARS-CoV-2 spike protein and CpG-ODNs, a Toll-like receptor 9 agonist, as an adjuvant. In vitro and in vivo experiments indicated the absence of toxicity following the intranasal administration of this vaccine formulation. First, we found that subcutaneous or intranasal vaccination ...
Tópico(s): Bacterial Infections and Vaccines
2023 - Multidisciplinary Digital Publishing Institute | Vaccines
Produção Nacional
Revisado por pares
Paula Brito e Cabral, José Evandro Cunha Júnior, Alexandre Casimiro de Macedo, Alexandre Rodrigues Alves, Thially Braga Gonçalves, Tereza Cristina Brito e Cabral, Ana Paula Soares Gondim, Maria Isabel Moraes Pinto, Karen Oseki, Lília Maria Carneiro Câmara, Sílvia Helena Barem Rabenhorst, Aparecida Tiemi Nagao‐Dias,
ObjectivesLeprosy household contacts represent a group at high risk of developing the disease. The aim of this study was to detect Mycobacterium leprae subclinical infection in this group through serological and molecular parameters.MethodsSerum anti-PGL1 IgG/IgM and salivary anti-PGL1 IgA/IgM was investigated using an ELISA, and nasal carriage of M. leprae DNA was detected by PCR, in leprosy household contacts of paucibacillary (PB) and multibacillary (MB) household leprosy patients (n = 135), their ...
Tópico(s): Infectious Diseases and Tuberculosis
2013 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
José A. Marengo, Lincoln M. Alves, Regina C. S. Álvala, Ana Paula Martins do Amaral Cunha, Sheila B. Brito, Osvaldo L. L. Moraes,
This study discusses the climatological aspects of the most severe drought ever recorded in the semiarid region Northeast Brazil. Droughts are recurrent in the region and while El Nino has driven some of these events others are more dependent on the tropical North Atlantic sea surface temperature fields. The drought affecting this region during the last 5 years shows an intensity and impact not seen in several decades in the regional economy and society. The analysis of this event using drought ...
Tópico(s): Hydrology and Watershed Management Studies
2017 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
SHEILA S.B. BRITO, Ana Paula Martins do Amaral Cunha, C. C. Cunningham, Regina Célia dos Santos Alvalá, José A. Marengo, M. A. de Carvalho,
ABSTRACT Drought is the natural disaster that impacts the greatest number of people and produces the most significant economic losses. This work presents a quantitative assessment of drought events occurred in the Semiarid region of Northeast Brazil during 1981–2016. The purpose of this study is to provide an overview of drought intensity for the last 36 years, analysing their severity, frequency and duration, considering hydro‐meteorological and agricultural aspects. To evaluate these two aspects, ...
Tópico(s): Climate variability and models
2017 - Wiley | International Journal of Climatology
Produção Nacional
Revisado por pares
Nicole Cristine Rigonato‐Oliveira, Auriléia Aparecida de Brito, Luana Beatriz Vitoretti, Gabriel de Cunha Moraes, Tawany Gonçalves, Karine Zanella Herculano, Cíntia Estefano Alves, Adriana Lino‐dos‐Santos‐Franco, Flávio Aimbire, Rodolfo P. Vieira, Ana Paula Ligeiro de Oliveira,
Asthma is characterized by chronic inflammation in the airways. Several models have been proposed for the discovery of new therapies. Low-Level Laser Therapy (LLLT) is relatively new and effective, very low cost, with no side effects. However, there is still no consensus on the optimal dose to be used. In this sense, the objective of the present study was to evaluate the best dose in an experimental model of asthma induced by House Dust Mite (HDM). Balb/c mice received administration of 100 ug/animal ...
Tópico(s): Respiratory and Cough-Related Research
2019 - Hindawi Publishing Corporation | International Journal of Inflammation
Produção Nacional
Revisado por pares
Ana Letícia Rodrigues Costa, Andresa Gomes, Laís Brito Cangussu, Rosiane Lopes Cunha, Leandro S. Oliveira, Adriana S. Franca,
Oil-in-water (O/W) emulsions stabilized by cellulose nanocrystals (CNC) and/or sunflower proteins (SFP) were produced, aiming to study the effects of each and the mixture of these stabilizers on the interfacial behavior and physicochemical properties of O/W emulsions. The presence of CNC (non-surface activity compound) did not affect SFP solutions' adsorption kinetics since there were no differences in the interfacial tension curves of SFP and mixtures of stabilizers over time. However, either stabilizer ...
Tópico(s): Proteins in Food Systems
2021 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Juliana Gil Melgaço, Danielle Brito e Cunha, Tamiris Azamor, Andréa Marques Vieira da Silva, Luciana Tubarão, Rafael Braga Gonçalves, Robson Q. Monteiro, Sotiris Missailidis, Patrícia Neves, Ana Paula Dinis Ano Bom,
The severe acute respiratory syndrome caused by the new coronavirus (SARS-CoV-2), termed COVID-19, has been highlighted as the most important infectious disease of our time, without a vaccine and treatment available until this moment, with a big impact on health systems worldwide, and with high mortality rates associated with respiratory viral disease. The medical and scientific communities have also been confronted by an urgent need to better understand the mechanism of host-virus interaction aimed ...
Tópico(s): Dermatological and COVID-19 studies
2020 - Hindawi Publishing Corporation | Journal of Immunology Research
Alexandre de Freitas Azevedo, Ana Bernadete Lima Fragoso, José Lailson‐Brito, Haydée A. Cunha,
The franciscana (Pontoporia blainvillei) inhabits coastal waters of the western South Atlantic from Espirito Santo State (~18oS), Brazil (Siciliano, 1994) to Chubut Province (~42oS), Argentina (Crespo et al., 1998). Its distribution was assumed to be continuous. However recent studies have pointed out the existence of two discontinuities along the species range: between Ubatuba (23o20S) and Macae (22o25S) and between Barra de Itabapoana (21o18S) and Regencia (19o40S), southeastern Brazil (Siciliano and ...
Tópico(s): Ichthyology and Marine Biology
2002 - | Latin American Journal of Aquatic Mammals
Produção Nacional
Revisado por pares
Milena Morais Vieira, Francisco Macedo, José Nelson Belarmino Filho, Ana Carolina Leite Vieira Costa, Adriano França da Cunha, Edilberto R. Silveira, Gerly Anne de Castro Brito, Ronaldo A. Ribeiro,
To compare the classical uroprotective efficacy of mesna (2-mercaptoethanesulfonic acid) with ternatin (flavonoid isolated from Egletes viscosa Less.) in cyclophosphamide (CYP) and ifosfamide (IFS) induced hemorrhagic cystitis (HC). Male Wistar rats received an intraperitoneal injection of saline, CYP or IFS and were treated with saline or mesna, 5 min before, 4 and 8 h after CYP or IFS administration. In other animals, 1, 2 or 3 doses of mesna were replaced with ternatin or 3 doses of mesna were replaced ...
Tópico(s): Chemotherapy-induced organ toxicity mitigation
2004 - Wiley | Phytotherapy Research
Produção Nacional
Revisado por pares
Thaíse Gabriele da Silva Brito, Ana Paula Sant’Anna da Silva, Rebeca Xavier da Cunha, Caíque Silveira Martins da Fonseca, Tiago Ferreira da Silva Araújo, Janaína Karin de Lima Campos, Weber Melo Nascimento, Hallysson Douglas Andrade de Araújo, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Bianka Santana dos Santos, Vera Lúcia de Menezes Lima,
Plinia cauliflora (Mart.) Kausel, known in Brazil as jabuticaba or jaboticaba has been used by Brazilian native populations for medicinal purposes, including those related to inflammatory conditions, such as asthma, diarrhea, disorders in female genitourinary tract, and tonsillitis. Inflammation has emerged as a main factor for the oxidative stress, hyperglycemia, and dyslipidemia present in chronic noncommunicable diseases (NCDs). Such disturbances have been a leading cause of death worldwide for ...
Tópico(s): Phytochemistry Medicinal Plant Applications
2020 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Ana Paula Martins do Amaral Cunha, Javier Tomasella, Germano Ribeiro Neto, Matthew Brown, Sâmia Regina Garcia, Sheila B. Brito, M. A. de Carvalho,
In Northeast Brazil (NEB), severe droughts have high socioeconomic impacts. In this study, the spatial–temporal characteristics of drought were evaluated based on a new drought index at 4‐km spatial resolution, derived from regional empirical relationships between a remote sensing‐based index and rain‐gauge‐based standardized precipitation index (SPI), a well‐known drought meteorological index. This index was used to compare the spatial pattern of severe drought events (1982–1983, 1992–1993, 1997–1998, ...
Tópico(s): Flood Risk Assessment and Management
2018 - Wiley | Atmospheric Science Letters
Produção Nacional
Revisado por pares
José Lailson‐Brito, Paulo R. Dorneles, Cláudio E. Azevedo-Silva, Alexandre de Freitas Azevedo, Lara G. Vidal, R.C. Zanelatto, C.P.C. Lozinski, Antônio Azeredo, Ana Bernadete Lima Fragoso, Haydée A. Cunha, João Paulo Machado Torres, Olaf Malm,
Blubber samples from 33 Guiana dolphins (Sotalia guianensis) from three estuaries (Guanabara, Sepetiba/Ilha Grande and Paranaguá Bays) of Southern and Southeastern Brazil were analyzed for organochlorine compounds (DDTs, PCBs and HCB). The sampled individuals were incidentally captured in gillnet fishery between 1995 and 2005. The concentrations (in ng/g lipids) varied from 652 to 23 555 for SigmaDDT; from 765 to 99 175 for SigmaPCB; and from <4.4 to 156 for HCB. The results have shown that cetaceans ...
Tópico(s): Marine animal studies overview
2009 - Elsevier BV | Environmental Pollution
Produção Nacional
Revisado por pares
Ana Cecília Cavalcanti de Albuquerque, Débora Maria da Silva, Deyse Caroline Cabral Rabelo, Waldenia Agny Torres de Lucena, Paloma Cássia Silva de Lima, Maria Rosângela Cunha Duarte Coêlho, Guilherme Gustavo de Brito Tiago,
Os detentos apresentam maior vulnerabilidade ao HIV e outras Infecções Sexualmente Transmissíveis (IST) devido a fatores de risco como: compartilhamento de seringas e sexo desprotegido. O objetivo do presente trabalho foi determinar a soroprevalência e fatores de risco para o HIV-1/2 e sífilis entre presidiários do sexo masculino em Caruaru, Pernambuco, Brasil. Foi realizado um corte transversal no período de maio a julho de 2011, no qual 1097 detentos de uma penitenciária de Caruaru foram avaliados, ...
Tópico(s): Adolescent Sexual and Reproductive Health
2014 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Maysa F. Zampa, Ana Cristina Facundo de Brito, Igor Lebedenco Kitagawa, Carlos J. L. Constantino, Osvaldo N. Oliveira, Helder Nunes da Cunha, Valtencir Zucolotto, José Ribeiro dos Santos Júnior, Carla Eiras,
Natural gums have been traditionally applied in cosmetics and the food industry, mainly as emulsification agents. Due to their biodegradability and excellent mechanical properties, new technological applications have been proposed involving their use with conventional polymers forming blends and composites. In this study, we take advantage of the polyelectrolyte character exhibited by the natural gum Chichá (Sterculia striata), extracted in the Northeastern region of Brazil, to produce electroactive ...
Tópico(s): Conducting polymers and applications
2007 - American Chemical Society | Biomacromolecules
Produção Nacional
Revisado por pares
Camila Fonseca Bezerra, Érika Freitas Mota, Ana Claudia M. Silva, A.R. Tomé, Maria Z.R. Silva, Daniel Brito, Camila T.M.N. Porfírio, Ariclécio Cunha de Oliveira, José Vitor Lima‐Filho, Márcio V. Ramos,
Many thousands of plants are disseminated worldwide in traditional and folk medicines based on the belief that their leaves, roots, seeds, bark or secretions, when adequately handled, can treat, alleviate or ameliorate numerous disease symptoms. Calotropis procera (Apocynaceae) is a popular medicinal plant and the claims of this shrub's phytomedicinal properties have been scientifically validated. In this study, further prospects towards the in vivo toxicity and oral immunological tolerance of phytomodulatory ...
Tópico(s): Phytochemistry and Bioactive Compounds
2017 - Elsevier BV | Chemico-Biological Interactions
Produção Nacional
Revisado por pares
Laura C. Rodrigues, Susan Martins Pereira, Sérgio Souza da Cunha, Bernd Genser, Maria Yury Ichihara, Silvana C de Brito, Miguel Aiub Hijjar, Ãlvaro A. Cruz, Clemax Couto Sant’Anna, Ana Luiza Bierrenbach, Maurício L. Barreto, Inês Dourado,
Tópico(s): Immune responses and vaccinations
2005 - Elsevier BV | The Lancet
Produção Nacional
Revisado por pares
Ana Luiza Bierrenbach, Sérgio Souza da Cunha, Maurício L. Barreto, Susan Martins Pereira, Inês Dourado, Maria Yuri Ichihara, Silvana C de Brito, Laura C. Rodrigues,
OBJECTIVE: To investigate the influence of BCG vaccination or revaccination on tuberculin skin test reactivity, in order to guide the correct interpretation of this test in a setting of high neonatal BCG vaccination coverage and an increasing BCG revaccination coverage at school age. METHODS: We conducted tuberculin skin testing and BCG scar reading in 1148 children aged 7-14 years old in the city of Salvador, Bahia, Brazil. We measured the positive effect of the presence of one or two BCG scars ...
Tópico(s): Immune responses and vaccinations
2003 - Pan American Health Organization | Revista Panamericana de Salud Pública
Célia Costa, Isabel Rosmaninho, Arminda Guilherme, José Alberto Ferreira, Joana Antunes, Ana Ortins‐Pina, Sara Prates, João Gaspar Marques, Filomena Azevedo, Ana Paula Cunha Chaves, Celeste Brito, António Fernandes Massa, João Sousa, Glória Velho, Inês Raposo, Gabriela Marques Pinto, V. Teixeira de Sousa, Ana Rodrigues Martins,
Introduction: There is a paucity of information regarding chronic urticaria patients’ care in a real-world setting. The objective of this study was to report and evaluate the baseline characteristics of Portuguese chronic urticaria patients refractory to H1-antihistamines included in the AWARE study. Material and Methods: This is a non-interventional cohort study. Adult patients with a diagnosis of chronic urticaria with symptoms for at least two months, refractory to H1-antihistamines, consulting ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2019 - Ordem dos Médicos | Acta Médica Portuguesa
Produção Nacional
Revisado por pares
Ana Clécia Campos Brito, Cácio Luiz Boechat, Antonny Francisco Sampaio de Sena, Lizandra de Sousa Luz Duarte, Clístenes Williams Araújo do Nascimento, Yuri Jacques Agra Bezerra da Silva, Ygor Jacques Agra Bezerra da Silva, Paloma Cunha Saraiva,
Tópico(s): Radioactivity and Radon Measurements
2020 - Springer Science+Business Media | Water Air & Soil Pollution
Produção Nacional
Revisado por pares
Andrew Dauber, Marina Cunha-Silva, Delanie B. Macedo, Vinícius Nahime Brito, Ana Paula Abreu, Stephanie Roberts, Luciana Ribeiro Montenegro, Melissa Andrew, Andrew Kirby, Matthew T. Weirauch, Guillaume Labilloy, Danielle S. Bessa, Rona S. Carroll, Dakota C. Jacobs, Patrick E. Chappell, Berenice B. Mendonça, David Haig, Ursula B. Kaiser, Ana Claudia Latrônico,
Abstract Context: Central precocious puberty (CPP) results from premature activation of the hypothalamic–pituitary–gonadal axis. Few genetic causes of CPP have been identified, with the most common being mutations in the paternally expressed imprinted gene MKRN3. Objective: To identify the genetic etiology of CPP in a large multigenerational family. Design: Linkage analysis followed by whole-genome sequencing was performed in a family with five female members with nonsyndromic CPP. Detailed phenotyping ...
Tópico(s): Genomics and Chromatin Dynamics
2017 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Revisado por pares
Haydée A. Cunha, Vera Maria Ferreira da Silva, José Lailson‐Brito, Marcos César de Oliveira Santos, P.A.C. Flores, Anthony R. Martin, Alexandre de Freitas Azevedo, Ana Bernadete Lima Fragoso, R.C. Zanelatto, Antônio M. Solé‐Cava,
Tópico(s): Ichthyology and Marine Biology
2005 - Springer Science+Business Media | Marine Biology
Produção Nacional
Revisado por pares
Andréa Marques Vieira da Silva, Thiago Lazari Machado, Raphaela Delmondes do Nascimento, Miguel Tréfaut Rodrigues, Felipe Soares Coelho, Luciana Tubarão, L. De Rosa, Camilla Bayma, Vanessa Pimenta Rocha, Ana Frederico, Jane da Silva, Danielle Brito e Cunha, Alessandro Fonseca de Souza, Rosana Barros de Souza, Caroline A. Barros, Danielle da Silva Fiscina, Luiz Cláudio Pereira Ribeiro, Carlos Alberto Marques de Carvalho, B. Silva, Rodrigo Müller, Tamiris Azamor, Juliana Gil Melgaço, Rafael Braga Gonçalves, Ana Paula Dinis Ano Bom,
Lactoferrin (Lf) is an important immunomodulator in infections caused by different agents. During SARS-CoV-2 infection, Lf can hinder or prevent virus access to the intracellular environment. Severe cases of COVID-19 are related to increased production of cytokines, accompanied by a weak type 1 interferon response.
Tópico(s): SARS-CoV-2 and COVID-19 Research
2024 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Tamiris Azamor, Ingrid Horbach, Danielle Brito e Cunha, Juliana Gil Melgaço, Andréa Marques Vieira da Silva, Luciana Tubarão, Adriana de Souza Azevedo, Renata Tourinho Santos, Nathalia dos Santos Alves, Thiago Lazari Machado, Jane Silva, Alessandro Fonseca de Souza, Camilla Bayma, Vanessa Pimenta Rocha, Ana Frederico, Brenda de Moura Dias, Bruno Pimenta Setatino, Caio Bidueira Denani, Samir Pereira da Costa Campos, Waleska Dias Schwarcz, Michel Sucupira, Edinéa Pastro Mendes, Edimílson Domingos da Silva, Sheila Maria Barbosa de Lima, Ana Paula Dinis Ano Bom, Sotiris Missailidis,
Infections caused by SARS-CoV-2 induce a severe acute respiratory syndrome called COVID-19 and have led to more than six million deaths worldwide. Vaccination is the most effective preventative measure, and cellular and humoral immunity is crucial to developing individual protection. Here, we aim to investigate hybrid immunity against SARS-CoV-2 triggered by the ChAadOx1 nCoV-19 vaccine in a Brazilian cohort. We investigated the immune response from ChAadOx1 nCoV-19 vaccination in naïve (noCOVID- ...
Tópico(s): Vaccine Coverage and Hesitancy
2022 - Multidisciplinary Digital Publishing Institute | Viruses