Mónica Torres-Ruíz, Mercedes de Alba González, Mònica Morales, Raquel Martín-Folgar, María del Carmén González, Ana Cañas, Antonio De la Vieja,
Nanoplastics (NP) are present in aquatic and terrestrial ecosystems. Humans can be exposed to them through contaminated water, food, air, or personal care products. Mechanisms of NP toxicity are largely unknown and the Zebrafish embryo poses an ideal model to investigate them due to its high homology with humans. Our objective in the present study was to combine a battery of behavioral assays with the study of endocrine related gene expression, to further explore potential NP neurotoxic effects on ...
Tópico(s): Nanoparticles: synthesis and applications
2023 - Elsevier BV | The Science of The Total Environment
Cortés Melissa Paola, Amaya María Camila, Cañas Ana, Osorio Marlon, Sánchez Diego, Robín Zuluaga, Beatriz Gómez, Castro Cristina,
Collagen is the most abundant fibrous protein in animal's body and is widely used for biomedical and pharmaceutical applications. The principal sources of this protein are bovine, porcine and fish skin and bones. In Colombia, bovine bones are waste from meat industry, this material have potential as an alternative source of collagen isolation. The aim of this study was to evaluate the composition and some properties of type I collagen (COL I) extracted of bovine bones of Zebu-Bos Primigenius Indicus ...
Tópico(s): Bone and Dental Protein Studies
2019 - Elsevier BV | Heliyon
Juan Pedro Arrebola, Juan José Ramos, Mónica Bartolomé, Marta Esteban, Olga Huetos, Ana Cañas, Ana López-Herranz, Eva Calvo, Beatriz Pérez‐Gómez, Argelia Castaño,
Hyperuricemia is becoming a serious public health issue, which is highly influenced by environmental factors, although there is still controversial information on the potential influence of the exposure to Persistent Toxic Substances (PTSs) in the general population. In this study we aimed to assess the association. PTS exposure with uric acid homeostasis in a sample of the Spanish population. Participants were recruited during 2009-2010 in all the main geographical areas of Spain. Exposure to 34 ...
Tópico(s): Bone and Joint Diseases
2019 - Elsevier BV | Environment International
Raquel Martín-Folgar, María del Carmén González, Mónica Torres-Ruíz, Ana Cañas, Mercedes de Alba González, Isabel Liste, Mònica Morales,
Nanoplastics (NPs) have been found in many ecological environments (aquatic, terrestrial, air). Currently, there is great concern about the exposition and impact on animal health, including humans, because of the effects of ingestion and accumulation of these nanomaterials (NMs) in aquatic organisms and their incorporation into the food chain. NPs´ mechanisms of action on humans are currently unknown. In this study, we evaluated the altered molecular mechanisms on human neural stem cell line (hNS1) ...
Tópico(s): Nanoparticles: synthesis and applications
2024 - Public Library of Science | PLoS ONE
María del Carmén González, Mercedes de Alba González, Mónica Torres-Ruíz, Patricia Iglesias-Hernández, Verónica Zapata, María C. Terrón, Martin Sachse, Mònica Morales, Raquel Martín-Folgar, Isabel Liste, Ana Cañas,
Global plastic production has increased exponentially in recent decades, and a significant part of it persists in the environment, where it degrades into microplastics and nanoplastics (MPs and NPs). These can enter in humans by ingestion, inhalation, and dermal routes, and there is scientific evidence that they are able to reach the systemic circulation and penetrate and accumulate in various tissues and organs. Neurodevelopmental toxicity of NPs is one of the most worrying effects, as they can ...
Tópico(s): Nanoparticles: synthesis and applications
2024 - Elsevier BV | Chemosphere
Ángel Borque‐Fernando, J. Rubio‐Briones, Luis Esteban, Yan Dong, Ana Calatrava, Á. Gómez-Ferrer, Enrique Gómez‐Gómez, Jesús M. Gil Fabra, Nuria Rodríguez-García, P.Á. López González, J. Garcı́a Rodrı́guez, M. Rodrigo-Aliaga, Bernardo Herrera‐Imbroda, Juan Soto-Villalba, S. Martínez-Breijo, Virginia Hernández-Cañas, Ana M. Soto-Poveda, Carlos Sánchez-Rodríguez, Carlos Carrillo-George, Yumaira E. Hernández-Martínez, David Okrongly,
Tópico(s): Urologic and reproductive health conditions
2018 - Springer Nature | Prostate Cancer and Prostatic Diseases
J. A. Cañas, Ana Tabares, Claudia Barbero, Daniel García‐Sánchez, Beatriz Sastre, José M. Rodrigo‐Muñoz, Ignacio Mahíllo, Ana Rayo, Belén Borrell, M L Cilleruelo, Enriqueta Román, Sonia Fernández‐Fernández, Carolina Gutiérrez‐Junquera, Victoria del Pozo,
ABSTRACT Objectives: Eosinophilic esophagitis (EoE) is a chronic esophageal disease characterized by eosinophilic inflammation. Proton‐pump inhibitors (PPI) induce disease remission but no predictive factors of PPI‐responsiveness have been identified yet. So, a biomarker must be found to differentiate between responders (PPI‐R) and nonresponder patients (PPI‐NR) to PPI. Aims were to identify any molecular biomarker that could predict PPI responsiveness and to study molecular remission after PPI therapy. ...
Tópico(s): IL-33, ST2, and ILC Pathways
2020 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition
Lupe Carolina Espinoza, Marcelle Silva-Abreu, Beatriz Clares, María J. Rodríguez-Lagunas, Lyda Halbaut, María-Alexandra Cañas, Ana C. Calpena,
Donepezil (DPZ) is widely used in the treatment of Alzheimer's disease in tablet form for oral administration. The pharmacological efficacy of this drug can be enhanced by the use of intranasal administration because this route makes bypassing the blood⁻brain barrier (BBB) possible. The aim of this study was to develop a nanoemulsion (NE) as well as a nanoemulsion with a combination of bioadhesion and penetration enhancing properties (PNE) in order to facilitate the transport of DPZ from nose-to-brain. ...
Tópico(s): Drug Solubulity and Delivery Systems
2019 - Multidisciplinary Digital Publishing Institute | Pharmaceutics
Paula M. Canas, Ana Patrícia Simões, Ricardo J. Rodrigues, Rodrigo A. Cunha,
Alzheimer's disease (AD) is characterized phenotypically by memory impairment, neurochemically by accumulation of β-amyloid peptide (such as Aβ1–42) and morphologically by an initial loss of nerve terminals in cortical and hippocampal regions. However, it is not known what nerve terminals are mostly affected in early AD. We now used a mouse model of AD, based on the intra-cerebral administration of soluble Aβ1-42, that leads to memory impairment and loss of nerve terminal markers within 2 weeks, to ...
Tópico(s): Memory and Neural Mechanisms
2013 - Elsevier BV | Neuropharmacology
Delfín Rupérez Cañas, Ana Lucila Sandoval Orozco, Luis Javier García Villalba, P.-S. Hong,
Mobile ad hoc networks (MANETs) are formed by wireless mobile devices that do not require a predefined infrastructure and where all nodes are at the same level without the need of a central coordinator. The routing is an important task in this kind of networks because of highly dynamic environments and other characteristics. Routing consists of sending the information from sender nodes to destination nodes in a multihop manner. There are different techniques to solve the routing problem. We rely ...
Tópico(s): UAV Applications and Optimization
2013 - Hindawi Publishing Corporation | International Journal of Distributed Sensor Networks
Luis Javier García Villalba, Delfín Rupérez Cañas, Ana Lucila Sandoval Orozco,
A mobile ad hoc network (MANET) is a non-centralised, multihop, wireless network that lacks a common infrastructure. It therefore needs self-organisation. The MANETs are autonomous, adaptive and dynamic. In MANETs, multihop routing allows multiple routes between the source and destination to be established. This study speaks about a bio-inspired routing protocol for these networks based on AntHocNet. The design for the protocol lies in a heuristic, based on swarm intelligence, which takes into account ...
Tópico(s): Energy Efficient Wireless Sensor Networks
2010 - Institution of Engineering and Technology | IET Communications
Argelia Castaño, Jinny Sánchez-Rodríguez, Ana Cañas, Marta Esteban, Carmen Navarro, Ana C. Rodríguez-García, Misericordia Arribas, Gema Díaz, José A. Jiménez-Guerrero,
Human biomonitoring is a well-recognized tool for estimating the exposure of human populations to environmental pollutants. However, information regarding biomarker concentrations of many environmental chemicals in the general population is limited for many countries. The Spanish Environment Ministry has recently funded a human biomonitoring study on the Spanish general population. This study aims to determine reference levels for several biomarkers, especially heavy metals, persistent organic pollutants ( ...
Tópico(s): Heavy metals in environment
2011 - Elsevier BV | International Journal of Hygiene and Environmental Health
Raquel Martín-Folgar, Celia Sabroso, Ana Cañas, Mónica Torres-Ruíz, María del Carmén González, Helena Dorado, Ignacio Velasco, Mònica Morales,
In this work, we analyzed the early molecular effects of polystyrene (PS) nanoplastics (NPs) on an aquatic primary consumer (larvae of Chironomus riparius, Diptera) to evaluate their potential DNA damage and the transcriptional response of different genes related to cellular and oxidative stress, endocrine response, developmental, oxygen transport, and immune response. After 24-h exposures of larvae to doses of PS NPs close to those currently found in the environment, the results revealed a large genotoxic ...
Tópico(s): Marine Biology and Environmental Chemistry
2023 - Elsevier BV | Chemosphere
Jinny Sánchez-Rodríguez, Mónica Bartolomé, Ana Cañas, Olga Huetos, Carmen Navarro, A. Carolina Rodríguez, Misericordia Arribas, Marta Esteban, Ana Laura López, Argelia Castaño,
Anti-smoking legislation has been associated with an improvement in health indicators. Since the cadmium (Cd) body burden in the general population is markedly increased by smoke exposure, we analyzed the impact of the more restrictive legislation that came into force in Spain in 2011 by measuring Cd and cotinine in first morning urine samples from 83 adults in Madrid (Spain) before (2010) and after (2011) introduction of this law. Individual pair-wise comparisons showed a reduction of creatinine corrected ...
Tópico(s): Mercury impact and mitigation studies
2014 - Elsevier BV | Environmental Research
Birgit Schindler, Marta Esteban, Holger M. Koch, Argelia Castaño, Stephan Koslitz, Ana Cañas, Ludwine Casteleyn, Marike Kolossa‐Gehring, Gerda Schwedler, Greet Schoeters, Elly Den Hond, Ovnair Sepai, Karen Exley, Louis Bloemen, Milena Horvat, Lisbeth E. Knudsen, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Ana Laura López, Olga Huetos, Andromachi Katsonouri, Katja Maurer-Chronakis, Lucie Kašparová, Karel Vrbík, Péter Rudnai, Miklós Náray, Cédric Guignard, Marc Fischer, Danuta Ligocka, Beata Janasik, M. Fátima Reis, Sónia Namorado, Cristian Pop, Irina Dumitraşcu, Katarína Halzlová, Eleonóra Fabiánová, Darja Mazej, Janja Snoj Tratnik, Marika Berglund, Bo Jönsson, Andrea Lehmann, Pierre Crettaz, Hanne Frederiksen, Flemming Nielsen, Helena McGrath, Ian Nesbitt, Koen De Cremer, Guido Vanermen, Gudrun Koppen, Michael Wilhelm, Kerstin Becker, J. Angerer,
COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to “develop a coherent approach on human biomonitoring (HBM) in Europe”. Within this twin-project it was targeted to collect specimens from 120 mother–child-pairs in each of the 17 participating European countries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine, cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described ...
Tópico(s): Toxic Organic Pollutants Impact
2013 - Elsevier BV | International Journal of Hygiene and Environmental Health
Louise Ramhøj, Marta Axelstad, Yoni Baert, Ana Cañas, Frédéric Chalmel, Lars Dahmen, Antonio De la Vieja, Bertrand Evrard, Ann-Cathrin Haigis, Timo Hamers, K. Heikamp, Henrik Holbech, Patricia Iglesias-Hernández, Dries Knapen, Lorna Davida Marchandise, Jane Ebsen Morthorst, Nikolai Georgiev Nikolov, Ana Caroline Vasconcelos Engedal Nissen, Michael Oelgeschlaeger, Kostja Renko, Vera Rogiers, Gerrit Schüürmann, Evelyn Stinckens, Mette H. Stub, Mónica Torres-Ruíz, Majorie B.M. van Duursen, Tamara Vanhaecke, Lucia Vergauwen, Eva Bay Wedebye, Terje Svingen,
Current test strategies to identify thyroid hormone (TH) system disruptors are inadequate for conducting robust chemical risk assessment required for regulation. The tests rely heavily on histopathological changes in rodent thyroid glands or measuring changes in systemic TH levels, but they lack specific new approach methodologies (NAMs) that can adequately detect TH-mediated effects. Such alternative test methods are needed to infer a causal relationship between molecular initiating events and adverse ...
Tópico(s): Retinoids in leukemia and cellular processes
2023 - Frontiers Media | Frontiers in Toxicology
Teresa Valero, Laura del Barrio, Javier Egea, Noelia Cañas, Ana Martı́nez, Antonio G. Garcı́a, Mércedes Villarroya, Manuela G. López,
Marine sponges are becoming a rich source of potential new medicines. NP04634 is a synthetic derivative of 11,19 dideoxyfistularin, a natural product of the Mediterranean sponge Aplysina cavernicola. We report the cytoprotective effects of this new compound in isolated bovine chromaffin cells exposed to cytotoxic stimuli that have been related to neuronal cell death, i.e. Ca(2+) overload and mitochondrial dysfunction. Cell death was achieved by: (i) causing Ca(2+) overload through voltage-dependent ...
Tópico(s): Aldose Reductase and Taurine
2009 - Elsevier BV | European Journal of Pharmacology
Philip Marx‐Stoelting, Gilles Rivière, Mirjam Luijten, Kiara Aiello, Nicole Bandow, Kirsten A. Baken, Ana Cañas, Argelia Castaño, Sébastien Denys, Clémence Fillol, Matthias Herzler, Ivo Iavicoli, Spyros Karakitsios, Jana Klánová, Marike Kolossa‐Gehring, A. Koutsodimou, Joana Lobo Vicente, Iseult Lynch, Sónia Namorado, S. Norager, Amelia Pittman, Stefanie Rotter, Dimosthenis Sarigiannis, Maria João Silva, Jan Theunis, Tewes Tralau, Maria Uhl, Jacob van Klaveren, Lina Wendt-Rasch, E. Westerholm, Christophe Rousselle, P. Sanders,
Current approaches for the assessment of environmental and human health risks due to exposure to chemical substances have served their purpose reasonably well. Nevertheless, the systems in place for different uses of chemicals are faced with various challenges, ranging from a growing number of chemicals to changes in the types of chemicals and materials produced. This has triggered global awareness of the need for a paradigm shift, which in turn has led to the publication of new concepts for chemical ...
Tópico(s): Radioactivity and Radon Measurements
2023 - Springer Science+Business Media | Archives of Toxicology
Eva Govarts, Liese Gilles, Laura Rodríguez Martín, Tiina Santonen, Petra Apel, Paula Alvito, Elena Anastasi, Helle Raun Andersen, Anna‐Maria Andersson, Lenka Andrýsková, Jean‐Philippe Antignac, Brice M. R. Appenzeller, Fabio Barbone, Zohar Barnett‐Itzhaki, Robert Barouki, T. Berman, Wieneke Bil, Teresa Borges, Jurgen Buekers, Ana Cañas, Adrian Covaci, Zsófia Csákó, Elly Den Hond, Darina Dvořáková, Lucia Fábelová, Tony Fletcher, Hanne Frederiksen, Catherine Gabriel, Catherine Ganzleben, Thomas Göen, Þórhallur I. Halldórsson, Line Småstuen Haug, Milena Horvat, Pasi Huuskonen, Medea Imboden, Marta Jagodic Hudobivnik, Beata Janasik, Nataša Janev Holcer, Spyros Karakitsios, Andromachi Katsonouri, Jana Klánová, Venetia Kokaraki, Tina Kold Jensen, Jani Koponen, Michelle Laeremans, Federica Laguzzi, Rosa Lange, Nora Lemke, Sanna Lignell, Anna Karin Lindroos, Joana Lobo Vicente, Mirjam Luijten, Konstantinos C. Makris, Darja Mazej, Lisa Melymuk, Matthieu Meslin, Hans Mol, Parisa Montazeri, Aline Murawski, Sónia Namorado, Lars Niemann, Stefanie Nübler, Baltazar Nunes, Kristín Ólafsdóttir, Ľubica Palkovičová, N. Papaioannou, Susana Pedraza‐Díaz, Pavel Piler, Veronika Plichta, Michael Poteser, Nicole Probst‐Hensch, Loïc Rambaud, Elke Rauscher‐Gabernig, Katarína Rausová, Sylvie Rémy, Margaux Riou, Valentina Rosolen, Christophe Rousselle, Maria Rüther, Dimosthenis Sarigiannis, Maria João Silva, Zdenka Šlejkovec, Janja Snoj Tratnik, Anja Stajnko, Tamás Szigeti, José Tarazona, Cathrine Thomsen, Žiga Tkalec, Hanna Tolonen, T. Trnovec, Maria Uhl, An Van Nieuwenhuyse, Elsa Vasco, Veerle J. Verheyen, Susana Viegas, Anne Marie Vinggaard, Nina Vogel, Katrin Vorkamp, Wojciech Wąsowicz, Till Weber, Soňa Wimmerová, Marjolijn Woutersen, Philipp Zimmermann, Martin Zvonař, Holger M. Koch, Marike Kolossa‐Gehring, Marta Esteban, Argelia Castaño, Lorraine Stewart, Ovnair Sepai, Greet Schoeters,
As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6-12 years, (ii) 3,117 teenagers aged 12-18 years and (iii) ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2023 - Elsevier BV | International Journal of Hygiene and Environmental Health
Tiina Santonen, Selma Mahiout, Paula Alvito, Petra Apel, Jos Bessems, Wieneke Bil, Teresa Borges, Stephan Böse‐O’Reilly, Jurgen Buekers, Ana Cañas, Argelia Castaño, Mercedes de Alba González, Noelia Domínguez-Morueco, Marta Esteban, Ingrid Falnoga, Antje Gerofke, María del Carmén González, Milena Horvat, Pasi Huuskonen, Normunds Kadiķis, Marike Kolossa‐Gehring, Rosa Lange, Henriqueta Louro, Carla Martins, Matthieu Meslin, Lars Niemann, Susana Pedraza‐Díaz, Veronika Plichta, Simo P. Porras, Christophe Rousselle, Bernice Scholten, Maria João Silva, Zdenka Šlejkovec, Janja Snoj Tratnik, Agnes Šömen Joksić, José Tarazona, Maria Uhl, An Van Nieuwenhuyse, Susana Viegas, Anne Marie Vinggaard, Marjolijn Woutersen, Greet Schoeters,
One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2023 - Elsevier BV | International Journal of Hygiene and Environmental Health
Nina Vogel, Phillipp Schmidt, Rosa Lange, Antje Gerofke, Amrit Kaur Sakhi, Line Småstuen Haug, Tina Kold Jensen, Hanne Frederiksen, Tamás Szigeti, Zsófia Csákó, Ľubica Palkovičová, Miroslava Šidlovská, Beata Janasik, Wojciech Wąsowicz, Janja Snoj Tratnik, Darja Mazej, Catherine Gabriel, Spyros Karakitsios, Fabio Barbone, Valentina Rosolen, Loïc Rambaud, Margaux Riou, Aline Murawski, Daan L. A. C. Leseman, Gudrun Koppen, Adrian Covaci, Sanna Lignell, Anna Karin Lindroos, Martin Zvonař, Lenka Andrýsková, Lucia Fábelová, Denisa Richterová, Milena Horvat, Tina Kosjek, Dimosthenis Sarigiannis, Marios Maroulis, Susana Pedraza‐Díaz, Ana Cañas, Veerle J. Verheyen, Michiel Bastiaensen, Liese Gilles, Greet Schoeters, Marta Esteban, Argelia Castaño, Eva Govarts, Holger M. Koch, Marike Kolossa‐Gehring,
Phthalates are mainly used as plasticizers for polyvinyl chloride (PVC). Exposure to several phthalates is associated with different adverse effects most prominently on the development of reproductive functions. The HBM4EU Aligned Studies (2014-2021) have investigated current European exposure to ten phthalates (DEP, BBzP, DiBP, DnBP, DCHP, DnPeP, DEHP, DiNP, DiDP, DnOP) and the substitute DINCH to answer the open policy relevant questions which were defined by HBM4EU partner countries and EU institutions ...
Tópico(s): Pharmaceutical studies and practices
2023 - Elsevier BV | International Journal of Hygiene and Environmental Health
José Tarazona, María del Carmén González, Mercedes de Alba-Gonzalez, Susana Pedraza‐Díaz, Ana Cañas, Noelia Domínguez-Morueco, Marta Esteban, Irene Cattaneo, Andromachi Katsonouri, Konstantinos C. Makris, Þórhallur I. Halldórsson, Kristín Ólafsdóttir, Jan‐Paul Zock, Jonatan V. Dias, Annelies De Decker, Bert Morrens, T. Berman, Zohar Barnett‐Itzhaki, Christian Lindh, Liese Gilles, Eva Govarts, Greet Schoeters, Till Weber, Marike Kolossa‐Gehring, Tiina Santonen, Argelia Castaño,
The risk assessment of pesticide residues in food is a key priority in the area of food safety. Most jurisdictions have implemented pre-marketing authorization processes, which are supported by prospective risk assessments. These prospective assessments estimate the expected residue levels in food combining results from residue trials, resembling the pesticide use patterns, with food consumption patterns, according to internationally agreed procedures. In addition, jurisdictions such as the European ...
Tópico(s): Pesticide Residue Analysis and Safety
2022 - Multidisciplinary Digital Publishing Institute | Toxics
José Tarazona, Irene Cattaneo, Lars Niemann, Susana Pedraza‐Díaz, María del Carmén González, Mercedes de Alba-Gonzalez, Ana Cañas, Noelia Domínguez-Morueco, Marta Esteban, Argelia Castaño, Teresa Borges, Andromachi Katsonouri, Konstantinos C. Makris, Ilse Ottenbros, Hans Mol, Annelies De Decker, Bert Morrens, T. Berman, Zohar Barnett‐Itzhaki, Nicole Probst‐Hensch, Samuel Fuhrimann, Janja Snoj Tratnik, Milena Horvat, Loïc Rambaud, Margaux Riou, Greet Schoeters, Eva Govarts, Marike Kolossa‐Gehring, Till Weber, Petra Apel, Sónia Namorado, Tiina Santonen,
Pyrethroids are a major insecticide class, suitable for biomonitoring in humans. Due to similarities in structure and metabolic pathways, urinary metabolites are common to various active substances. A tiered approach is proposed for risk assessment. Tier I was a conservative screening for overall pyrethroid exposure, based on phenoxybenzoic acid metabolites. Subsequently, probabilistic approaches and more specific metabolites were used for refining the risk estimates. Exposure was based on 95th ...
Tópico(s): Pesticide and Herbicide Environmental Studies
2022 - Multidisciplinary Digital Publishing Institute | Toxics
Raquel Martín-Folgar, Mónica Torres-Ruíz, Mercedes de Alba, Ana Cañas, María del Carmén González, Mònica Morales,
Plastics pose a health hazard to living beings and the environment. Plastic degradation produces nano-sized plastic particles (NPs) that end up in terrestrial and aquatic ecosystems, including oceans, rivers, and lakes. Their presence in air, drinking water, sediments, food, and personal care products leads to a variety of exposure routes for living beings, including humans. The toxicity mechanisms of these nanomaterials (NMs) in living organisms and ecosystems are currently unknown, making it a priority ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2022 - Elsevier BV | Chemosphere
Mónica Torres-Ruíz, Antonio De la Vieja, Mercedes de Alba González, Marta Esteban, Argelia Castaño, Ana Cañas,
Nanoplastics (NP) are an emerging threat to human health and there is a need to understand their toxicity. Zebrafish (ZF) is extensively used as a toxicology model due to its power to com-bine genetic, cellular, and whole organism endpoints. The present review integrates results regarding polystyrene NP effects on ZF embryo development. Study design was evaluated against NP effects. NP size, concentration, and exposure time did not affect organism responses (mortality, development, heart rate, locomotion) ...
Tópico(s): Pluripotent Stem Cells Research
2021 - Elsevier BV | The Science of The Total Environment
Marta Esteban, Juan Pedro Arrebola, Miguel Juliá, Peter Pärt, E.P. Soto, Ana Cañas, Susana Pedraza‐Díaz, Juana María González-Rubio, Argelia Castaño,
Exposure to mercury, even at low doses, can affect human health, well-being and life quality at a broad scale. Human biomonitoring is the most straightforward approach to measure and quantify mercury exposure in humans. The objective of the present study is to compare and discuss the relationships between Hg levels in the most used matrices, hair, urine and blood, with the aim to ascertain to what extent mercury exposure and internal mercury levels could be predicted by monitoring non-invasive matrices. ...
Tópico(s): Air Quality and Health Impacts
2021 - Elsevier BV | Environmental Research
Sonia Labeau, Elsa Afonso, Julie Benbenishty, Bronagh Blackwood, Carole Boulanger, Stephen J. Brett, Silvia Calviño-Günther, Wendy Chaboyer, Fiona Coyer, Mieke Deschepper, Guy François, Patrick M. Honoré, Radmilo Janković, Ashish K. Khanna, Mireia Llauradó‐Serra, Frances Lin, Louise Rose, Francesca Rubulotta, Leif Saager, Ged Williams, Stijn Blot, Dritan Muzha, Antoni Margarit Ribas, Fernando Lipovesty, Cecilia Loudet, Fiona Coyer, Philipp Eller, Nafseen Mostafa, Patrick M. Honoré, Vanesa Mercado Telleria, Jasmina Smajić, Paula Cristina Nogueira, Khalid Mahmood Khan Nafees, Romuald Hentchoya, Louise Rose, Javiera Soledad, Frances Lin, Yenny Cardenas, A. Reyes, Alan S̆ustić, Meropi Mpouzika, Tamas Vymazal, Hanne Irene Jensen, Hernán Aguirre-Bermeo, Liivi Maddison, M. Valta, Silvia Calviño-Günther, Frank Bloos, Faustina Excel Adipa, Vasilios Koulouras, Judy Enamorado Enamorado, Zsuzsann Ágoston, Hrönn Birgisdóttir, Amit Gupta, Mohan Gurjar, Bram Kilapong, Seyed Mohammad Reza Hashemian, Ignacio Martín‐Loeches, Julie Benbenishty, Andrea Cortegiani, Kelly Fletcher, Yoshiro Hayashi, Wangari Waweru-Siika, Khalid Abidi, Sang‐Min Lee, B. Hadri, Mihails Dolgusevs, Fayez Abillama, Tomas Jovaiša, Cyril A Thix, Muhammed Elhadi, Mohd Basri Mat Nor, Shanti Ratnam, Mohd Zulfakar Mazlan, Sundaresan Maiyalagan, Luis Alejandro Sánchez‐Hurtado, Adrian Belii, Mendsaikhan Naranpurev, Prabha Gautam, Dylan W. de Lange, Rachael Parke, Rose Ilesanmi, Mirjana Shosholcheva, Antonija Petosic, Ranveig Lind, Madiha Hashmi Ffarcsi, Javier Bogarin, Aaron Mark Hernandez, Małgorzata Mikaszewska-Sokolewicz, B. A. M. Sousa, Dana Tomescu, Dorel Săndesc, Théogène Twagirumugabe, V. G. Gusarov, Maie Salem Ebaid, Radmilo Janković, Gari Slobodianiuk, Andrea Martonova, Rihard Knafelj, Mervyn Mer, Emilio Maseda, Bernardo Panka, Joerg C. Schefold, Eva Joelsson‐Alm, Konlawij Trongtrakul, Lorna Merritt-Charles, Lamia Ouanes-Besbes, Yalım Dikmen, Л. В. Згржебловська, Mark Fielding, Francesca Rubulotta, Ashish K. Khanna, Leif Saager, Ingrid von der Osten, Dritan Muzha, Alban Greca, Alma Cani, Nordian Xhindi, Genci Hyska, Antonio Margarit Ribas, Susana Pinto-Castilla, Paulo Alves, Romina Esposito, Emanuel Valgolio, John Thomas Sanchez Miñope, Antonio Abdala, Maria Ayala, Silvina Bravo, Ana Bantar, Patricia Delgado, Gustavo Badariotti, Fernando Lipovestky, Ana María Díaz, Pablo Saul, Mariano Setten, Alejandra Aucapina, Ysica Acosta, V. González, Luis Alberto Camputaro, Fernando Baccaro, Robert Villa, Ana María Díaz, Marcela Mastantuono, Emiliano Dean, Oscar Fernández Rostello, Patricia Brizuela, Julio Ricardo Bartoli, Matias Guereschi, Cristian Quiroga, Sofia Putruele, Paula Romina Villegas, Veronica Curilen, Rubén Fernández, Mariangeles Gabriela Nocheretti, Rosana Gabriela Escalante, Cecilia Loudet, Silvia Fernandez, Ana Laura González, Gustavo Andres Alvarez, Federico Iglesias, S. Jansen Chaparro, Graciela Zakalik, Gonzalo Pagella, Matías Baini, Pierina Arias Campos, Ignacio Sabbag, Armando Schmukler, Imelda Perdomo Fonseca, Gonzalo Martín Alvarez, Mário Ramirez, Fernando Velasco-Tapia, Carlos Alejandro Bascary, G. Giménez, Fernando Bertoletti, Esteban Milioto, Pablo Julio Maldonaldo Bonsignore, María Alejandra Fernández, Julie Smith, Tim Chimunda, Lorraine Thompson, Teena Maguire, Frances Lin, Wendy Chaboyer, Fiona Coyer, Stacey Watts, Marion Mitchell, Madeleine Powell, India Lye, Leanne Parsons, Nerilee Baker, Claire Reynolds, Amy Thompson, Kristy Masters, Kellie Sosnowski, Lynette Morrison, Gavin Leslie, Ramanathan Lakshmanan, Alexis Tabah, Wendy Brown, Sharon McDowell-Skaines, Andrea McLucas, Chris Smith, Mandy Tallot, Sarah Jones, Michelle Barakat‐Johnson, Thomas K. Leong, Rand Butcher, Kerrie Martin, Philipp Douschan, Dirk von Lewinski, Philipp Eller, René Schmutz, Uta Kolussi, Fatema Salman, Zainab Mahdi Ateya, Nafseen Mostafa, Koen De Decker, Niels Van Regenmortel, Anita Jans, Patricia Wijnands, Stefano Coremans, Patrick M. Honoré, David De Bels, Tanja Depuydt, Caroline Paillet, Luc‐Marie Jacquet, Walter Swinnen, Francis Hannes, M Mergeay, Stijn Van de Velde, Silvie Allaert, Pieter Hoste, Christophe Borin, Sandrine Balon, Vincent Fraipont, Patrick Biston, Nicolas De Schryver, Thierry Dugernier, Ilse Van Cotthem, Vanesa Mercado Telleria, Jasmina Smajić, Angélica Olivetto de Almeida, Sílvia Angélica Jorge, Delmiro Becker, Raysa Cristina Schmidt, Evellyn Oliveira, Aline de Oliveira Ramalho, Eliane Mazócoli, Audrey Fioretti, Elaine Barros, Letícia Faria Serpa, Suzana Maria Bianchini, Ticiane Carolina Gonçalves Faustino Campanili, Taís Pantaleao, Paulo Carlos Garcia, Ana Lucia Vitti Ronchini, Rayanne Santos, Khalid Mahmood Khan Nafees, Nurulhuda Binti A. Manap, Romuald Hentchoya, Sean M. Bagshaw, Dominic Carney, Sean M. Bagshaw, Jon Davidow, Sean M. Bagshaw, Ella Rokosh, Sean M. Bagshaw, Andréa Maria Laizner, Samantha Smith, Megan McQuirter, Betty Star Kampayana, René Favre, Martin Sills, Andréa Maria Laizner, Julie Dallaire, Andréa Maria Laizner, Cathy Becker, Sherissa Microys, B. Bowes, Jennifer LaJeunesse, Rishi Ghosh, Jacqueline Baptiste-Savoie, Rose Raizman, Sean M. Bagshaw, Gabriel Suen, Noushin Taghavi, Orla Smith, Clare Fielding, Louise Rose, J R López Canales, Pia Molina, Javiera Chaparro, Maria Idalia Sepulveda, Matias Jesús Flamm Zamorano, P..c. Túlio Monteiro de Castro e Abreu Rocha, Ximena Villanueva,
Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were ...
Springer Science+Business Media
Argelia Castaño, Susana Pedraza‐Díaz, Ana Cañas, Beatriz Pérez‐Gómez, Juan José Ramos, Mónica Bartolomé, Peter Pärt, E.P. Soto, Miguel Motas, Carmen Navarro, E. Calvo, Marta Esteban,
Mercury (Hg) is among the top 10 environmental chemicals of major public health concern (WHO). The Minamata Convention on Mercury (United Nations Environment Program, 2017), commits signing countries to control anthropogenic mercury emissions and reduce human exposure. Human biomonitoring (HBM) programs, are the most straight-forward approaches to get information on the actual exposure levels in the population and assess over time. We report here the results of a HBM study in a nationwide cross-section ...
Tópico(s): Toxic Organic Pollutants Impact
2019 - Elsevier BV | The Science of The Total Environment
Marika Berglund, Kristin Larsson, Margaretha Grandér, Ludwine Casteleyn, Marike Kolossa‐Gehring, Gerda Schwedler, Argelia Castaño, Marta Esteban, J. Angerer, Holger M. Koch, Birgit Schindler, Greet Schoeters, Roel Smolders, Karen Exley, Ovnair Sepai, Luies Blumen, Milena Horvat, Lisbeth E. Knudsen, Thit Aarøe Mørck, Anke Joas, Reinhard Joas, Pierre Biot, Dominique Aerts, Koen De Cremer, Ilse Van Overmeire, Andromachi Katsonouri, Adamos Hadjipanayis, Milena Černá, Andrea Krsková, Jeanette K.S. Nielsen, Janne Jensen, Péter Rudnai, Szilvia Középesy, Chris Griffin, Ian Nesbitt, Arno C. Gutleb, Marc Fischer, Danuta Ligocka, M. Jakubowski, M. Fátima Reis, Sónia Namorado, Ioana-Rodica Lupsa, Anca Elena Gurzău, Katarína Halzlová, Michal Jajcaj, Darja Mazej, Janja Snoj Tratnik, Ana Laura López, Ana Cañas, Andrea Lehmann, Pierre Crettaz, Elly Den Hond, Eva Govarts,
The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term environmental exposure, but with insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults and developmental effects in children. This study is the first pan-European human biomonitoring project that succeeded in performing harmonized measurements of Cd in urine in a comparable way in mother-child ...
Tópico(s): Environmental Justice and Health Disparities
2014 - Elsevier BV | Environmental Research
Rita Canas‐Marques, Ana Félix,
Tópico(s): Cancer and Skin Lesions
2014 - Springer Science+Business Media | Virchows Archiv