Yegor Morozov, A.S. Castela, Ana Paula Soares Dias, M.F. Montemor,
Concrete properties can be improved by various additives. Nowadays there is a strong interest concerning the use of spent fluid catalytic cracking catalyst (SFCC) as an admixture to improve mechanical properties of concrete. This work aims at studying the corrosion resistance of steel rebars in SFCC modified mortar specimens. Results of physicochemical characterization indicate the acceleration of cement hydration due to pozzolanic activity of SFCC. Electrochemical measurements show that the addition ...
Tópico(s): Concrete and Cement Materials Research
2013 - Elsevier BV | Cement and Concrete Research
Urban tourism has in the last 5 years grown expansively, especially in Southern Europe and the Mediterranean .Lisbon is no exception.In the last four years, there has been a major development in urban tourism, a trend that will certainly continue increasing thanks to being named the best 'city break' destination in 2017.Residents play a very crucial role in the development of cultural tourism.The literature indicates that when residents perceive tourism as beneficial there is a greater level of interaction ...
Tópico(s): Place Attachment and Urban Studies
2018 - | Athens Journal of Tourism
... um recorte da seguinte matéria da revista Veja “Ana Castela, estrela do ‘agronejo': ‘Hoje quem manda é a ...
Tópico(s): Cultural, Media, and Literary Studies
2024 - | Muiraquitã - Revista de Letras e Humanidades
Maria Castela, A. S. Veríssimo, Ana Maura Araújo Rocha, Mário Costa,
This article examines the combustion regimes occurring in a small-scale laboratory cylindrical combustor, in which the burner and the exhaust port are mounted at the top end of the combustion chamber. Flue-gas composition data and hydroxyl radical chemiluminescence (OH*) imaging are presented as a function of the air inlet preheat temperature and excess air coefficient, which in the present configuration implies also changes in the air inlet velocity. For three of these combustor operating conditions, ...
Tópico(s): Radiative Heat Transfer Studies
2012 - Taylor & Francis | Combustion Science and Technology
João S. Teodoro, Ivo F. Machado, Ana C. Castela, Anabela P. Rolo, Carlos M. Palmeira,
The proton electrochemical gradient generated by respiratory chain activity accounts for over 90% of all available ATP and, as such, its evaluation and accurate measurements regarding its total values and fluctuations is an invaluable component in the understanding of mitochondrial functions. Consequently, alterations in electric potential across the inner mitochondrial membrane generated by differential protonic accumulations and transport are known as the mitochondrial membrane potential, or Δψ, ...
Tópico(s): Metabolism and Genetic Disorders
2020 - Springer Science+Business Media | Methods in molecular biology
Ivo F. Machado, João S. Teodoro, Ana C. Castela, Carlos M. Palmeira, Anabela P. Rolo,
Metformin is the most used biguanide drug for the treatment of type 2 diabetes mellitus. Despite being mostly known for its hepatic anti-gluconeogenic effect, it is also known to modulate microRNAs (miRNAs, miRs) associated with metabolic diseases. The latter mechanism could be relevant for better understanding metformin’s mechanisms underlying its biological effects. In the current work, we found that metformin increases miR-378a-3p expression (p < 0.002) in C2C12 myoblasts previously exposed to hyperglycemic ...
Tópico(s): Pancreatic function and diabetes
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Sílvia Fernandes, Ana Belo, Guilherme Castela,
This study analyzes uses of social networks by small and medium-sized enterprises (SMEs) at the Algarve region in Portugal. Results suggest that some firms have integrated their business strategies with social networks, and have groups of professionals responsible for these platforms. Most managers perceive that social networks enhance business performance, but few measure the results. Firms that most frequently use social networks have managers with higher qualifications. This study identified two ...
Tópico(s): Knowledge Management and Sharing
2015 - Elsevier BV | Technology in Society
João S. Teodoro, Ivo F. Machado, Ana C. Castela, João A. Amorim, Ivana Jarak, Rui A. Carvalho, Carlos M. Palmeira, Anabela P. Rolo,
Bile acids (BA) have shown promising effects in animal models of obesity. However, the said effects are thought to rely on a thermogenic effect, which is questionably present in humans. A previous work has shown that the BA chenodeoxycholic acid (CDCA) can revert obesity and accelerate metabolism in animal and cell culture models. Thus, the aim of this study was to understand if this obesity reduction is indeed thermogenically-dependent. A CRISPR/Cas9 model of TGR5 (BA receptor) knockdown in 3T3-L1 ...
Tópico(s): Drug Transport and Resistance Mechanisms
2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
... extracto del siguiente artículo de la revista Veja "Ana Castela, estrella del 'agronejo': 'Hoy manda la mujer'" (CAPUANO, ...
Tópico(s): Spanish Linguistics and Language Studies
2024 - CENTRO UNIVERSITÁRIO CAMPOS DE ANDRADE | Revista Scripta Uniandrade
Fernando Magro, Diogo Magalhães, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa, Helena Tavares de Sousa, Paula Ministro, Irinia Mocanu, Ana Vieira, Joana Castela, Joana Moleiro, Joana Roseira, Eugénia Cancela, Paula Sousa, Francisco Portela, L Correia, Mafalda Santiago, Sandra Dias, Catarina Alves, Joana Afonso, Silvio Danese, Laurent Peyrin–Biroulet, Cláudia Camila Dias,
Background and aims Subclinical intestinal inflammation is common in Crohn's disease (CD). We aimed to explore its impact in the disease progression of infliximab-treated patients and the usefulness of fecal calprotectin (FC) and C-reactive protein (CRP) as surrogate minimally invasive biomarkers. Methods The registry-based, prospective, observational, multicenter DIRECT (study to investigate the correlation of fecal calprotectin with serum Drug levels and development of an antI-dRug antibodiEs among adult patients ...
Tópico(s): Autoimmune and Inflammatory Disorders
2021 - Elsevier BV | Clinical Gastroenterology and Hepatology
Fernando Magro, María Manuela Estevinho, Gaia Catalano, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa, Helena Tavares de Sousa, Paula Ministro, Irina Mocanu, Ana Vieira, Joana Castela, Joana Moleiro, Joana Roseira, Eugénia Cancela, Paula Sousa, Francisco Portela, L Correia, Paula Moreira, Mafalda Santiago, Sandra Fernandes Dias, Joana Afonso, Silvio Danese, Laurent Peyrin‐Biroulet, Cláudia Camila Dias,
Abstract Background Timely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. Objective We aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression. Methods Data from 289 CD patients receiving infliximab (IFX) maintenance therapy for 2 years was collected; those patients were ...
Tópico(s): Eosinophilic Esophagitis
2023 - Wiley | United European Gastroenterology Journal
Elizabeth Pádua, Ricardo Parreira, Rita Tendeiro, Baltazar Nunes, J Castela, Isabel Soares, Ana Mouzinho, Eduarda Oliveira Reis, Maria Teresa Paixão,
HIV-1 mother-to-child transmission (MTCT) was evaluated in terms of the molecular characterization of the env and nef genomic regions and quantification of maternal RNA viral loads. Assignment of viral subtype was achieved by direct sequencing of PCR 1172products amplified from proviral DNA in 45 HIV-1-nontransmitting mothers (NTM), along with 13 pairs of HIV-1-transmitting mothers (TM) and their infected children (C). Analysis of the env C2V3C3 and nef sequences revealed that subtypes G and B, and ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - Mary Ann Liebert, Inc. | AIDS Research and Human Retroviruses
António Pires, Paula Martins, Artur Paiva, Ana Margarida Pereira, Margarida Marques, Eduardo Castela, Cristina M. Sena, Raquel Seiça,
This study aimed to investigate the relationship between circulating endothelial progenitor cell count and endothelial activation in a pediatric population with obesity.Observational and transversal study, including 120 children and adolescents with primary obesity of both sexes, aged 6-17 years, who were recruited at this Cardiovascular Risk Clinic. The control group was made up of 41 children and adolescents with normal body mass index. The variables analyzed were: age, gender, body mass index, ...
Tópico(s): Apelin-related biomedical research
2015 - Elsevier BV | Jornal de Pediatria
António Pires, Paula Martins, Ana Margarida Pereira, Margarida Marques, Eduardo Castela, Cristina M. Sena, Raquel Seiça,
Tópico(s): Cardiovascular Disease and Adiposity
2015 - Springer Science+Business Media | European Journal of Pediatrics
João S. Teodoro, João A. Amorim, Ivo F. Machado, Ana C. Castela, Clemens Steegborn, David Sinclair, Anabela P. Rolo, Carlos M. Palmeira,
Hepatic ischemia/reperfusion (I/R) injury is a leading cause of organ dysfunction and failure in numerous pathological and surgical settings. At the core of this issue lies mitochondrial dysfunction. Hence, strategies that prime mitochondria towards damage resilience might prove applicable in a clinical setting. A promising approach has been to induce a mitohormetic response, removing less capable organelles, and replacing them with more competent ones, in preparation for an insult. Recently, a soluble ...
Tópico(s): Cardiac Ischemia and Reperfusion
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Mafalda Simões, Catarina Marques, Ana Cristina Gonçalves, Ana Paula Esteves Pereira, Joaquim Correia, J Castela, Cristina Guerreiro,
The iatrogenic risk of HIV vertical transmission, calculated in initial epidemiologic studies, seemed to counterindicate invasive prenatal diagnosis (PND) procedures. The implementation of highly active antiretroviral therapy (HAART) represented a turning point in PND management, owing to a rapid and effective reduction of maternal viral load (VL). In the present study, we identified cases of vertical transmission in HIV-infected pregnant women who did amniocentesis in the second trimester of pregnancy (), ...
Tópico(s): Prenatal Screening and Diagnostics
2013 - Hindawi Publishing Corporation | Infectious Diseases in Obstetrics and Gynecology
Ana Catarina Pelicano, Maria C. T. Gonçalves, Daniela M. Godinho, Tiago Castela, M. Lurdes Orvalho, N. A. M. Araújo, Emily Porter, Raquel C. Conceição,
Breast cancer diagnosis using radar-based medical MicroWave Imaging (MWI) has been studied in recent years. Realistic numerical and physical models of the breast are needed for simulation and experimental testing of MWI prototypes. We aim to provide the scientific community with an online repository of multiple accurate realistic breast tissue models derived from Magnetic Resonance Imaging (MRI), including benign and malignant tumours. Such models are suitable for 3D printing, leveraging experimental ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2021 - Multidisciplinary Digital Publishing Institute | Sensors
Ana Belo, Guilherme Castela, Sílvia Fernandes,
O objetivo do presente artigo é analisar o potencial das redes sociais no desempenho das pequenas e médias empresas da região do Algarve, tendo sido efectuado um questionário para o efeito.O estudo empírico realizado revela que os dados recolhidos (de 70 empresas) possuem
Tópico(s): Technology Adoption and User Behaviour
2013 - AISTI | RISTI - Revista Ibérica de Sistemas e Tecnologias de Informação
Ana Belo, Guilherme Castela, Sílvia Fernandes,
The evolution of internet created new opportunities for small and medium enterprises (SME), among which are social networks. This work aims at analyzing the potential of these networks for the SME in Algarve, creating a questionnaire for the purpose. The empirical study revealed that some firms have already an integrated business strategy with social networks, as well as a group in the firm responsible for it. Most of their managers consider that social networks enhance performance, but few really ...
Tópico(s): Knowledge Management and Sharing
2013 - Springer Nature | Advances in intelligent systems and computing
Feliciano Chanana Paquissi, Valdano Manuel, Ana Mosalina Manuel, Guiomar Lote Mateus, Bruna David, Gertrudes Béu, Anselmo Castela,
The burden of cardiovascular diseases (CVD) is increasing in most countries of sub-Saharan Africa. However, as there is a scarcity of data, little is known about CVD in Angola. This study aimed to determine the prevalence of prehypertension, hypertension, prediabetes, diabetes, overweight, and obesity among workers at a private tertiary center in Angola.A cross-sectional study was conducted among 781 workers of Clínica Girassol, a tertiary health care center in Angola, during the month of November ...
Tópico(s): Blood Pressure and Hypertension Studies
2016 - Dove Medical Press | Vascular Health and Risk Management
António Pires, Paula Martins, Ana Margarida Pereira, Joana Marinho, Patrícia Vaz Silva, Margarida Marques, Eduardo Castela, Cristina M. Sena, Raquel Seiça,
Pediatric obesity is increasingly prevalent in the Portuguese population. Adipocyte dysfunction results in the expression of pro-inflammatory mediators that are responsible for the low-grade inflammatory process that characterizes obesity.The aim of this study was to investigate the relationship between markers of adiposity, inflammation and adipokines in a Portuguese obese pediatric population.One hundred and twenty children of both sexes, aged 6-17 years, were included in this study. The control ...
Tópico(s): Adipose Tissue and Metabolism
2014 - Elsevier BV | Revista Portuguesa de Cardiologia
António Pires, Paula Martins, Ana Margarida Pereira, Patrícia Vaz Silva, Joana Marinho, Margarida Marques, Eduardo Castela, Cristina M. Sena, Raquel Seiça,
Background: Obesity-related comorbidities are present in young obese children, providing a platform for early adult cardiovascular disorders.Objectives: To compare and correlate markers of adiposity to metabolic disturbances, vascular and cardiac morphology in a European pediatric obese cohort.Methods: We carried out an observational and transversal analysis in a cohort consisting of 121 obese children of both sexes, between the ages of 6 and 17 years.The control group consisted of 40 children with ...
Tópico(s): Cardiovascular Function and Risk Factors
2014 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Luz Boyero, Alonso Ramírez, David Dudgeon, Richard G. Pearson,
... Mathooko, José F. Gonçalves Jr, Marcelo S. Moretti, Ana Marcela Chará-Serna, Judy N. Davies, Andrea Encalada, Sylvain Lamothe, Leonardo M. Buria, José Castela, Aydeé Cornejo, Aggie O. Y. Li, Charles M' ...
Tópico(s): Freshwater macroinvertebrate diversity and ecology
2009 - University of Chicago Press | Journal of the North American Benthological Society
Andrew W. Stacey, Richard Bowman, Allen Foster, Tero Kivelä, Francis L. Munier, Nathalie Cassoux, Ido Didi Fabian, Lamis Al Harby, S. Alarcón Portabella, Donjeta B. Alia, Charlotta All‐Eriksson, Antonino Romanzo, Nick Astbury, Julia Balaguer, Walentyna Balwierz, Honorio Barranco, Covadonga Bascarán, Maja Popović, Eva Biewald, Nadia Bobrova, Norbert Bornfeld, Bénédicte G. Brichard, Sharon Blum, Michael Capra, Guilherme Castela, Jaume Catalá‐Mora, Guillermo Chantada, Violeta Chernodrinska, Krzysztof Cieślik, Codruta Comsa, Maria G. Correa Llano, Monika Csóka, Patrick De Potter, Laurence Desjardins, Monica Dragomir, Ana Fernández‐Teijeiro, David García Aldana, Pernille A. Gregersen, Nir Gomel, Theodora Hadjistilianou, Stanislava Hederová, Marlies Hummlen, Kristína Husáková, Ida Russo, Vesna R. Ilic, Helen Jenkinson, Noa Kapelushnik, Tamar Kardava, Naama Keren‐Froim, Tomáš Kepák, Zaza Khotenashvili, Artur Klett, Dalia Krivaitienė, Slobodanka Latinović, Livia Lumbroso‐Le Rouic, Lesia Lysytsia, Erika Maka, Nieves Martín Begué, Edoardo Midena, Annette C. Moll, Gabriela Murgoi, Л. В. Науменко, В. В. Нероев, Marina Nikitović, Andrzej Olechowski, Ruzanna Papyan, Raffaele Parrozzani, Manoj Parulekar, Katarzyna Pawińska-Wąsikowska, Sanja Perić, Pavel Pochop, V. G. Polyakov, M. Ashwin Reddy, Petra Ritter‐Sovinz, S. V. Saakyan, Mandeep S. Sagoo, Sonsoles San Román Pacheco, Stefan Seregard, Sónia Silva, Tetyana Sorochynska, Christina Stathopoulos, Branka Stirn Kranjc, Karel Švojgr, Gevorg Tamamyan, Alketa Tandili, Bekim Tateshi, Manca Tekavčič Pompe, Steen F. Urbak, Tatiana L. Ushakova, Sandra Valeiņa, Milo van Hoefen Wijsard, Nevyana Veleva, Maris Viksnins, Werner Wackernagel, Charlotte Wolley-Dod, V.А. Yarovaya, А.А. Yarovoy, Katsiaryna Zhilyaeva, Marcia Zondervan,
Retinoblastoma is the most common intraocular malignancy. Its incidence has been reported to be 1 case in from 15 000 to 18 000 live births, or approximately 12, 6, or 4 cases per 1 million children younger than 5, 10, or 15 years, respectively.1,2 The aim of this study was to estimate the incidence of retinoblastoma across European countries within a 1-year time frame. Data were collected through an international, multicenter, 1-year cross-sectional analysis that has been described in detail previously.
Tópico(s): Glioma Diagnosis and Treatment
2021 - Elsevier BV | Ophthalmology
Fernando Magro, Samuel Fernandes, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa, Helena Tavares de Sousa, Paula Ministro, Irina Mocanu, Ana Vieira, Joana Castela, Joana Moleiro, Joana Roseira, Eugénia Cancela, Paula Sousa, Francisco Portela, L Correia, Paula Moreira, Sandra Fernandes Dias, Joana Afonso, Silvio Danese, Laurent Peyrin‐Biroulet, Katarina Vučićević, Mafalda Santiago,
Abstract Background and aims Effective management of inflammatory bowel disease (IBD) relies on a comprehensive understanding of infliximab (IFX) pharmacokinetics (PK). This study’s primary goal was to develop a robust PK model, identifying key covariates influencing IFX clearance (CL), while concurrently evaluating the risk of disease progression during the maintenance phase of IBD treatment. Methods The multicenter, prospective, real-world DIRECT study was conducted in several care centers, which ...
Tópico(s): Pregnancy and Medication Impact
2024 - Oxford University Press | Journal of Crohn s and Colitis
Paula Sousa, Marta Patita, Bruno Arroja, Paula Lago, Isadora Rosa, Helena Tavares de Sousa, Paula Ministro, Irina Mocanu, Ana Vieira, Joana Castela, Joana Moleiro, Joana Roseira, Eugénia Cancela, Francisco Portela, L Correia, Mafalda Santiago, Sandra Dias, Catarina Alves, Joana Afonso, Cláudia Camila Dias, Fernando Magro,
BackgroundThe emergence of new treatments the inflammatory bowel diseases (IBD) raised questions regarding the role of older agents, namely thiopurines.AimsTo clarify the benefits of combination treatment with thiopurines on Crohn's disease (CD) patients in the maintenance phase of infliximab.MethodsIn this analysis of the 2-year prospective multicentric DIRECT study, patients were assessed in terms of clinical activity, faecal calprotectin (FC), C-reactive protein (CRP), and infliximab pharmacokinetics. ...
Tópico(s): Acute Lymphoblastic Leukemia research
2023 - Elsevier BV | Digestive and Liver Disease
Produção Nacional
Revisado por pares
Luz Boyero, Richard G. Pearson, David Dudgeon, Verónica Ferreira, Manuel A. S. Graça, Mark O. Gessner, Andrew J. Boulton, Éric Chauvet, Catherine M. Yule, Ricardo Albariño, Alonso Ramírez, Julie E. Helson, Marcos Callisto, M. Arunachalam, Julián Chará, Ricardo Figueroa, Jude M. Mathooko, José Francisco Gonçalves, Marcelo S. Moretti, Ana M. Chará‐Serna, Judy N. Davies, Andrea C. Encalada, Sylvain Lamothe, Leonardo Buria, José Castela, Aydeé Cornejo, Aggie O. Y. Li, Charles M’Erimba, Verónica Díaz Villanueva, María del Carmen Zúñiga, Christopher M. Swan, Leon A. Barmuta,
ABSTRACT Aim We tested the hypothesis that shredder detritivores, a key trophic guild in stream ecosystems, are more diverse at higher latitudes, which has important ecological implications in the face of potential biodiversity losses that are expected as a result of climate change. We also explored the dependence of local shredder diversity on the regional species pool across latitudes, and examined the influence of environmental factors on shredder diversity. Location World‐wide (156 sites from ...
Tópico(s): Species Distribution and Climate Change
2011 - Wiley | Global Ecology and Biogeography
Diana Figueiredo, Inês A. Marques, Ana Salomé Pires, Claudia F. Cavaleiro, L.C. Costa, Guilherme Castela, Joaquim Murta, Maria Filomena Botelho, Ana Margarida Abrantes,
Retinoblastoma (RB) is the most common ocular neoplasm in children, whose development depends on two mutational events that occur in both alleles of the retinoblastoma susceptibility gene (RB1). Regarding the nature of these mutational events, RB can be classified as hereditary if the first event is a germline mutation and the second one is a somatic mutation in retina cells or nonhereditary if both mutational events occur in somatic cells. Although the rate of survival of RB is significantly elevated, ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2023 - Multidisciplinary Digital Publishing Institute | Cancers
Miguel Ángel Tapia‐Serrano, Marina Lorenzo-Lancho, Ana Acedo-Castela, Pedro Antonio Sánchez Miguel,
Los juegos populares, tradicionales y autóctonos han sido una fuente de ocio, cultura y diversión durante varias generaciones. Sin embargo, hoy en día, su práctica se está perdiendo entre las nuevas generaciones de jóvenes. La deportivización presente en algunos de ellos ha generado que se cuestione su valor didáctico, lo que requiere una depuración deportiva que doten a los juegos populares y tradicionales de valores educativos que puedan transferirse a la sociedad actual. El modelo de aprendizaje ...
Tópico(s): Sports and Physical Education Studies
2024 - | Revista Española de Educación Física y Deportes
Inês Barreiros-Mota, João R. Araújo, Cláudia Marques, Laura Sousa, Juliana Morais, Inês Castela, Ana Faria, Maria Teresa Neto, Gonçalo Cordeiro‐Ferreira, Daniel Virella, Ana María Simón Pita, Luís Pereira‐da‐Silva, Conceição Calhau,
Early-life gut dysbiosis has been associated with an increased risk of inflammatory, metabolic, and immune diseases later in life. Data on gut microbiota changes in infants undergoing intestinal surgery requiring enterostomy are scarce. This prospective cohort study examined the enterostomy effluent of 29 infants who underwent intestinal surgery due to congenital malformations of the gastrointestinal tract, necrotizing enterocolitis, or spontaneous intestinal perforation. Initial effluent samples ...
Tópico(s): Digestive system and related health
2023 - Multidisciplinary Digital Publishing Institute | Microorganisms