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... Division When meat moves from steel to plastic Jaka Foods Group Ltd v Secretary of State for ... of Miranda, Sadler's Wells seeks funds, Fiction Ana No By Agustin Gomez Arcos (Secker Warburg, £5. ...
1980 - Gale Group | TDA
Juan M. Fernández‐Costa, Amparo García-López, S. Zúñiga, Victoria Fernández‐Pedrosa, Amelia Felipo-Benavent, Manuel Mata, Oihane Jaka, Ana Aiastui, Francisco Hernández‐Torres, Begoña Aguado, Manuel Pérez‐Alonso, Juan J. Vílchez, Adolfo López de Munaín, Rubén Artero,
Myotonic dystrophy type 1 (DM1) is caused by the expansion of CTG repeats in the 3′ untranslated region of the DMPK gene. Several missplicing events and transcriptional alterations have been described in DM1 patients. A large number of these defects have been reproduced in animal models expressing CTG repeats alone. Recent studies have also reported miRNA dysregulation in DM1 patients. In this work, a Drosophila model was used to investigate miRNA transcriptome alterations in the muscle, specifically ...
Tópico(s): RNA regulation and disease
2012 - Oxford University Press | Human Molecular Genetics
Javier Cañueto, Ane Jaka, Luís A. Corchete, Ana Ma. González-Pérez, R. García‐Castro, M.J. Fuente, I. Membrive, Álvaro March, A. Mañes, Raquel Rodriguez Posada, Ramón M. Pujol, Concepción Román‐Curto, Agustí Toll,
Perineural invasion (PNI) is a feature of poor prognosis in cutaneous squamous cell carcinoma (CSCC). The benefit of postoperative radiotherapy (PORT) in the management of CSCC with PNI is still not well established.We aimed to evaluate the usefulness of PORT in the treatment of CSCC with PNI so as to determine which patients would best benefit from this type of treatment.A retrospective multicenter cohort of 110 CSCCs with PNI was evaluated. Eighteen recurrent cases were excluded for subsequent analysis. ...
Tópico(s): Cutaneous Melanoma Detection and Management
2019 - Wiley | Journal of the European Academy of Dermatology and Venereology
Matej Milijaš Jotić, Anastasija Panevska, Ioan Iacovache, Rok Kostanjšek, Martina Mravinec, Matej Skočaj, Benoît Zuber, Ana Pavšič, Jaka Razinger, Š. Modic, Francesco Trenti, Graziano Guella, Kristina Sepčić,
Ostreolysin A6 (OlyA6) is a protein produced by the oyster mushroom (Pleurotus ostreatus). It binds to membrane sphingomyelin/cholesterol domains, and together with its protein partner, pleurotolysin B (PlyB), it forms 13-meric transmembrane pore complexes. Further, OlyA6 binds 1000 times more strongly to the insect-specific membrane sphingolipid, ceramide phosphoethanolamine (CPE). In concert with PlyB, OlyA6 has potent and selective insecticidal activity against the western corn rootworm. We analysed ...
Tópico(s): Insect Pest Control Strategies
2021 - Multidisciplinary Digital Publishing Institute | Toxins
Carla Solé, Ibai Goicoechea, Alai Goñi, Maike Schramm, María Armesto, María Arestin, Lorea Manterola, Maitena Tellaetxe-Abete, Aitor Alberdi, Léonor Nogueira, M. Roumiguié, José I. López, Juan Pablo Sanz Jaka, Ander Urruticoechea, Itziar Vergara, Ana Loizaga‐Iriarte, Miguel Unda, Arkaitz Carracedo, Bernard Malavaud, Charles H. Lawrie,
Prostate cancer (PCa) is the second most common cancer of men and is typically slow-growing and asymptomatic. The use of blood PSA as a screening method has greatly improved PCa diagnosis, but high levels of false positives has raised much interest in alternative biomarkers. We used next-generation sequencing (NGS) to elucidate the urinary transcriptome of whole urine collected from high-stage and low-stage PCa patients as well as from patients with the confounding diagnosis of benign hyperplasia ( ...
Tópico(s): Prostate Cancer Treatment and Research
2020 - Multidisciplinary Digital Publishing Institute | Cancers
Katarina Karničar, Igor Drobnak, Marko Petek, Vasilka Magdevska, Jaka Horvat, Robert Vidmar, Špela Baebler, Ana Rotter, Polona Jamnik, Štefan Fujs, Boris Turk, Marko Fonovič, Kristina Gruden, Gregor Kosec, Hrvoje Petković,
Omics approaches have significantly increased our understanding of biological systems. However, they have had limited success in explaining the dramatically increased productivity of commercially important natural products by industrial high-producing strains, such as the erythromycin-producing actinomycete Saccharopolyspora erythraea. Further yield increase is of great importance but requires a better understanding of the underlying physiological processes. To reveal the mechanisms related to erythromycin ...
Tópico(s): Plant-Microbe Interactions and Immunity
2016 - BioMed Central | Microbial Cell Factories
Oihane Jaka, Leire Casas-Fraile, Margarita Azpitarte, Ana Aiastui, Adolfo López de Munaín, Amets Sáenz,
Limb-girdle muscular dystrophy type 2A (LGMD2A) is characterised by muscle wasting and progressive degeneration of proximal muscles because of mutations in the CAPN3 gene. However, the underlying pathophysiological mechanisms of muscle degeneration are still not well understood. The objective of this study was to assess the relevance of genes with differential expression in the muscle of LGMD2A patients. For this purpose, we analysed their in vitro expression in primary cultures of human myoblasts ...
Tópico(s): RNA Research and Splicing
2017 - Cambridge University Press | Expert Reviews in Molecular Medicine
Jaka Jakob Hodnik, Žaklin Acinger-Rogić, Mentor Alishani, Tiina Autio, Ana Balseiro, John Berezowski, Luís Pedro Carmo, Ιlias Chaligiannis, Beate Conrady, Lina Costa, Iskra Cvetkovikj, Ivana Davidov, Marc Dispas, Igor Djadjovski, Elsa L. Duarte, Céline Faverjon, Christine Fourichon, Jenny Frössling, Anton Gerilovych, Jörn Gethmann, Jacinto Gomes, David Graham, Maria Guelbenzu‐Gonzalo, George J. Gunn, Madeleine K. Henry, Petter Hopp, Hans Houe, Elena Irimia, Jožica Ježek, Ramón A. Juste, Emmanouil Kalaitzakis, Jasmeet Kaler, Selçuk Kaplan, Polychronis Kostoulas, Kaspars Kovaļenko, Nada Knežević, Tanja Knific, Xhelil Koleci, Aurélien Madouasse, Alvydas Malakauskas, René Mandelík, Eleftherios Meletis, Madalina Mincu, Kerli Mõtus, Violeta Muñoz‐Gómez, Mihaela Niculae, Jelena Nikitović, M. Ocepek, Marie Tangen-Opsal, László Ózsvári, D. Papadopoulos, Theofilos Papadopoulos, Sinikka Pelkonen, M.P. Polak, Nicola Pozzato, Eglé Rapaliuté, Stefaan Ribbens, João Niza‐Ribeiro, Franz‐Ferdinand Roch, Liza Rosenbaum Nielsen, José Luis Sáez, Søren Saxmose Nielsen, G. van Schaik, Ebba Schwan, Blagica Sekovska, Jože Starič, Sam Strain, Petr Šatrán, Sabina Šerić–Haračić, Lena‐Mari Tamminen, Hans‐Hermann Thulke, Ivan Toplak, Erja Tuunainen, Sharon Verner, Štefan Vilček, Ramazan Yıldız, I.M.G.A. Santman-Berends,
The COST action "Standardising output-based surveillance to control non-regulated diseases of cattle in the European Union (SOUND control)," aims to harmonise the results of surveillance and control programmes (CPs) for non-EU regulated cattle diseases to facilitate safe trade and improve overall control of cattle infectious diseases. In this paper we aimed to provide an overview on the diversity of control for these diseases in Europe. A non-EU regulated cattle disease was defined as an infectious ...
Tópico(s): Viral Infections and Vectors
2021 - Frontiers Media | Frontiers in Veterinary Science
Špela Arhar Holdt, Jaka Čibej, Ana Zwitter Vitez,
This paper explores the possibility of identifying lexicographical needs of language users by analysing user-generated content in digital media, and presents an analysis of more than 1,000 language-related questions and comments posted on Slovene language advice sites, Facebook groups, and news forums. The questions stem from authentic situations of language disruptions that can be taken into account when improving the organisation of dictionary information in the digital environment. The comments ...
Tópico(s): linguistics and terminology studies
2016 - Oxford University Press | International Journal of Lexicography
Today’s concept of Open Government Data (OGD) for openness, transparency and ease of access of data owned by government agencies becomes increasingly important. This initiative emerges from the demand of data users for the data belongs to the government agencies. The data services providing an easy access, cheap, fast, and interoperability are needed by the users and becomes important indicator performance for respective government agencies. Statistical Data and Metadata Exchange (SDMX) is a new standard ...
Tópico(s): Big Data and Business Intelligence
2015 - Institute of Advanced Engineering and Science (IAES) | TELKOMNIKA Indonesian Journal of Electrical Engineering
Nika Cvelbar Weber, Jaka Razinger, Jerneja Jakopič, Valentina Schmitzer, M. Hudina, Ana Slatnar, Robert Veberič, Franci Štampar, Tilen Zamljen,
The polyphagous brown marmorated stink bug (Halyomorpha halys Stål.) is an important pest in many countries. Recently it was noticed that it can feed on and cause damage to strawberries (Fragaria × ananassa Duch.). The metabolic response of strawberries to brown marmorated stink bug attacks was studied. Brown marmorated stink bugs attacked strawberry fruit which had 18% lower total sugar content compared to that of the control treatment. However, organic acid content had no significant difference among ...
Tópico(s): Insect-Plant Interactions and Control
2021 - Multidisciplinary Digital Publishing Institute | Horticulturae
Lul Raka, Smilja Kalenc, Zrinka Bonjak, Ana Budimir, Stjepan Katić, Dubravko ijak, Gjyle Mulliqi‐Osmani, Dick Zoutman, Arbëresha Jaka,
Infections caused by bacteria of genus Acinetobacter pose a significant health care challenge worldwide. Information on molecular epidemiological investigation of outbreaks caused by Acinetobacter species in Kosova is lacking. The present investigation was carried out to enlight molecular epidemiology of Acinetobacter baumannii in the Central Intensive Care Unit (CICU) of a University hospital in Kosova using pulse field gel electrophoresis (PFGE). During March - July 2006, A. baumannii was isolated ...
Tópico(s): Bacterial biofilms and quorum sensing
2009 - Elsevier BV | The Brazilian Journal of Infectious Diseases
Živa Zajec, Jaka Dernovšek, Jernej Cingl, Iza Ogris, Marius Gedgaudas, Asta Zubrienė, Ana Mitrović, Simona Golič Grdadolnik, Martina Gobec, Tihomir Tomašič,
Triple-negative breast cancer (TNBC) remains a treatment challenge and requires innovative therapies. Hsp90, crucial for the stability of numerous oncogenic proteins, has emerged as a promising therapeutic target. In this study, we present the optimization of the Hsp90 C-terminal domain (CTD) inhibitor
Tópico(s): Computational Drug Discovery Methods
2024 - American Chemical Society | Journal of Medicinal Chemistry
Jaka Šikonja, Jernej Brecelj, Mojca Žerjav Tanšek, Barbka Repič Lampret, Ana Drole Torkar, Simona Klemenčič, Neza Lipovec, Valentina Stefanova Kralj, Sara Bertok, Jernej Kovač, Barbara Faganel Kotnik, Markéta Tesařová, Žiga Iztok Remec, Maruša Debeljak, Tadej Battelino, Urh Grošelj,
Tyrosinemia type 1 (HT1) is an inborn error of tyrosine catabolism that leads to severe liver, kidney, and neurological dysfunction. Newborn screening (NBS) can enable a timely diagnosis and early initiation of treatment. We presented the follow up of the only two Slovenian patients diagnosed with HT1. Metabolic control was monitored by measuring tyrosine, phenylalanine and succinylacetone from dried blood spots (DBSs). Retrograde screening of HT1 was performed from DBSs taken at birth using tandem ...
Tópico(s): Diet and metabolism studies
2021 - Elsevier BV | Molecular Genetics and Metabolism Reports
Tevž Gorjanc, Jaka Šikonja, Ana Drole Torkar, Mojca Žerjav Tanšek, Jernej Kovač, Sara Bertok, Maruša Debeljak, Zvezdana Dolenc-Stražar, Marija Meznarič, Jernej Mlakar, Mirko Topalović, Gorazd Mlakar, Tadej Battelino, Urh Grošelj,
Background/Objectives: The microtubule-associated scaffold protein 1 (MTUS1) gene affects the microtubule stability and cell polarity in the heart and could thus lead to the development of left ventricular noncompaction (LVNC). Pathological gene variants in MTUS1 are associated with pathological phenotypes in both cell cultures and animal models. However, the literature lacks human studies on the specific effects of the MTUS1 gene in heart disease, particularly in congenital LVNC. Methods: We present ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2025 - Multidisciplinary Digital Publishing Institute | Genes
Ana Kračun, M. Torkar, Jaka Burja, Bojan Podgornik,
The purpose of this investigation was to identify the distribution of ultrafine particles in a steel matrix introduced through a conventional melting and casting method, and above all to determine the methodology and analysing techniques suitable for the analysis and identification of ultrafine particles incorporated into the steel matrix.In the frame of this work, steels dispersed with Al2O3 ultrafine particles were produced by a conventional casting method and their microstructure investigated ...
Tópico(s): Corrosion Behavior and Inhibition
2016 - Institute of Metals and Technology | Materiali in tehnologije
Ana Klinc, Urh Grošelj, Matej Mlinarič, Matjaž Homan, Gašper Markelj, A. Novak, Andreja Širca Čampa, Jaka Šikonja, Tadej Battelino, Mojca Žerjav Tanšek, Ana Drole Torkar,
Introduction Glycogen storage disease type 1b (GSD-1b) is characterized by neutropenia and neutrophil dysfunction generated by the accumulation of 1,5-anhydroglucitol-6-phosphate in neutrophils. Sodium-glucose co-transporter 2 inhibitors, such as empagliflozin, facilitate the removal of this toxic metabolite and ameliorate neutropenia-related symptoms, including severe infections and inflammatory bowel disease (IBD). Our case series presents the treatment of three pediatric GSD-1b patients with empagliflozin ...
Tópico(s): Autoimmune Neurological Disorders and Treatments
2024 - Frontiers Media | Frontiers in Endocrinology
Anabel Rico, Andrea Valls, Garazi Guembelzu, Margarita Azpitarte, Ana Aiastui, Mónica Zufiría, Oihane Jaka, Adolfo López de Munaín, Amets Sáenz,
Abstract Background Limb-girdle muscular dystrophy R1 calpain 3-related (LGMDR1) is an autosomal recessive muscular dystrophy due to mutations in the CAPN3 gene. While the pathophysiology of this disease has not been clearly established yet, Wnt and mTOR signaling pathways impairment in LGMDR1 muscles has been reported. Results A reduction in Akt phosphorylation ratio and upregulated expression of proteins implicated in glycolysis (HK-II) and in fructose and lactate transport (GLUT5 and MCT1) in LGMDR1 ...
Tópico(s): Calpain Protease Function and Regulation
2023 - BioMed Central | Orphanet Journal of Rare Diseases
A. Tejera‐Vaquerizo, Simone Ribero, Susana Puig, Aram Boada, Sabela Paradela, D. Moreno‐Ramírez, Javier Cañueto, Blanca de Unamuno, Ana Brinca, M.Á. Descalzo, Simona Osella‐Abate, Paola Cassoni, Cristina Carrera, Sergi Vidal‐Sicart, Antoni Bennássar, R. Rull, Llúcia Alós, Celia Requena, Isidro Bolumar, V. Través, Ángel Plá, Almudena Fernández, Ane Jaka, María T. Fernández‐Figueres, Josep María Hilari, Pol Giménez‐Xavier, Ricardo Vieira, Rafael Botella‐Estrada, Concepción Román‐Curto, L. Ferrándiz, N. Iglesias-Pena, Carlos Ferrándiz, Josep Malvehy, Pietro Quaglino, Eduardo Nagore,
Abstract Mitotic rate is no longer considered a staging criterion for thin melanoma in the 8th edition of the American Joint Committee on Cancer Staging Manual. The aim of this observational study was to identify prognostic factors for thin melanoma and predictors and prognostic significance of sentinel lymph node (SLN) involvement in a large multicenter cohort of patients with melanoma from nine tertiary care hospitals. A total of 4249 consecutive patients with thin melanoma diagnosed from January ...
Tópico(s): Cutaneous lymphoproliferative disorders research
2019 - Wiley | Cancer Medicine
Jaka Razinger, Katja Fink, Ana KERIN, Š. Modic, Gregor Urek,
Spotted wing drosophila (Drosophila suzukii (Matsumura, 1931), Diptera, Drosophilidae) management is difficult mainly because of its short generation time, polyphagy and serrated ovipositor, but also because its larvae can pupate in the orchard soil and are thus protected from insecticide applications. We hypothesized that insect-pathogenic soil fungi could successfully infect Drosophila suzukii pupae in soil environment. We tested several entomopathogenic or soil fungi against pupae in a) conidia- ...
Tópico(s): Forest Insect Ecology and Management
2017 - University of Ljubljana, Biotechnical Faculty | Acta agriculturae Slovenica
Jaka Jakob Hodnik, Žaklin Acinger-Rogić, Mentor Alishani, Tiina Autio, Ana Balseiro, John Berezowski, Luís Pedro Carmo, Ιlias Chaligiannis, Beate Conrady, Lina Costa, Iskra Cvetkovikj, Ivana Davidov, Marc Dispas, Igor Djadjovski, Elsa L. Duarte, Céline Faverjon, Christine Fourichon, Jenny Frössling, Anton Gerilovych, Jörn Gethmann, Jacinto Gomes, David Graham, Maria Guelbenzu‐Gonzalo, George J. Gunn, Madeleine K. Henry, Petter Hopp, Hans Houe, Elena Irimia, Jožica Ježek, Ramón A. Juste, Emmanouil Kalaitzakis, Jasmeet Kaler, Selçuk Kaplan, Polychronis Kostoulas, Kaspars Kovaļenko, Nada Knežević, Tanja Knific, Xhelil Koleci, Aurélien Madouasse, Alvydas Malakauskas, René Mandelík, Eleftherios Meletis, Madalina Mincu, Kerli Mõtus, Violeta Muñoz‐Gómez, Mihaela Niculae, Jelena Nikitović, M. Ocepek, Marie Tangen-Opsal, László Ózsvári, D. Papadopoulos, Theofilos A. Papadopoulos, Sinikka Pelkonen, M.P. Polak, Nicola Pozzato, Eglé Rapaliuté, Stefaan Ribbens, João Niza-Ribeiro, Franz‐Ferdinand Roch, Liza Rosenbaum Nielsen, José Luis Sáez, Søren Saxmose Nielsen, G. van Schaik, Ebba Schwan, Blagica Sekovska, Jože Starič, Sam Strain, Petr Šatrán, Sabina Šerić–Haračić, Lena‐Mari Tamminen, Hans‐Hermann Thulke, Ivan Toplak, Erja Tuunainen, Sharon Verner, Štefan Vilček, Ramazan Yıldız, I.M.G.A. Santman-Berends,
[This corrects the article DOI: 10.3389/fvets.2021.688078.].
Tópico(s): Microbial infections and disease research
2022 - Frontiers Media | Frontiers in Veterinary Science
Laura Escolà‐Vergé, Guillermo Cuervo, Arístides de Alarcón, Dolores Sousa, Laura Varela Barca, Núria Fernández-Hidalgo, Arístides de Alarcón, Encarnación Gutiérrez‐Carretero, Rafael Luque‐Márquez, Blanca Anaya Baz, Luis Eduardo López-Cortés, Zaira Palacios Baena, María Victoria García López, Guillermo Ojeda, Antonio Pláta Ciézar, José María Reguera Iglesias, Ricardo Vivancos Delgado, Carmen Hidalgo-Tenorio, Sergio Sequera, Ch, María Carmen Fariñas, Claudia Gonzalez‐Rico, J.F. Gutiérrez-Díez, Gonzalo Cabezón Villalba, Javier López, José Alberto San Román, Benito Almirante, Laura Escolà‐Vergé, Rubén Fernández García, Núria Fernández-Hidalgo, M. T. Gonzalez-Alujas, Olga Maisterra, Gerard Oristrell, M.N. Pizzi, Pau Rello, Remedios Ríos, Albert Roque, Antonia Sambola, Toni Soriano, Guillermo Cuervo, Inmaculada Grau, Sara Grillo, Lourdes Mateu, Maria Lluïsa Pedro-Botet Montoya, Núria Vallejo, Marta Hernández‐Meneses, José M. Miró, Eduard Quintana, A J Barros, Mercè Gurguí, Alba Rivera, María Laura Castelo Corral, Efrén Sánchez Vidal, Dolores Sousa, Pérez Rodríguez, Dolores Sousa, Milagros Suárez, M Fernandez, Laura Varela Barca, Laura Vidal Bonet, Lara García-Álvarez, José A. Oteo, Adrián Jerónimo Baza, Carmen Olmos, Isidre Vilacosta, Laura Domínguez-Pérez, Francisco López‐Medrano, Javier T Solera, José Luis Moya Mur, Enrique Navas, Andrea Kallmeyer Mayor, Ana María Pello, Luis Nieto Roca, María Aguilera García, Carmen de las Cuevas Torres, Carmen Sáez Béjar, Daniel de Castro, Fernándo Domínguez, António Ramos, Patricia Muñoz García, María Olmedo, Maricela Valerio Minero, Elisa García Vázquez, Alicia Hernández Torres, Encarnación Moral Escudero, Miguel Ángel Goenaga Sánchez, Xavier Kortajarena Urkola, Karlos Reviejo Jaka, Elena Bereciartúa, Josune Goikoetxea, Regino Rodríguez, Martín Reyes Acevedo,
... Sánchez, MD, Xavier Kortajarena Urkola, MD, Karlos Reviejo Jaka, MD (Hospital Universitario Donostia, Donostia (GAMES affiliated hospital)). ...
Tópico(s): Cardiac Structural Anomalies and Repair
2020 - Elsevier BV | Clinical Microbiology and Infection
Jaka Dernovšek, Tjaša Goričan, Marius Gedgaudas, Živa Zajec, Dunja Urbančič, Ana Jug, Žiga Skok, Caterina Sturtzel, Martin Distel, Simona Golič Grdadolnik, Kesavan Babu, Ashna Panchamatia, Timothy R. Stachowski, Marcus Fischer, Janez Ilaš, Asta Zubrienė, Daumantas Matulis, Nace Zidar, Tihomir Tomašič,
Due to their impact on several oncogenic client proteins, the Hsp90 family of chaperones has been widely studied for the development of potential anticancer agents. Although several Hsp90 inhibitors have entered clinical trials, most were unsuccessful because they induced a heat shock response (HSR). This issue can be circumvented by using isoform-selective inhibitors, but the high similarity in the ATP-binding sites between the isoforms presents a challenge. Given that Hsp90 shares a conserved Bergerat ...
Tópico(s): Enzyme Structure and Function
2024 - Elsevier BV | European Journal of Medicinal Chemistry
... dotyczące funkcjonowania spoldzielni socjalnych w Polsce oraz w analizowanych wojewodztwach. Ukazana jest takze rola, jaką pelnią te podmioty w aktywizacji poprzez prace grup ...
Tópico(s): Polish Legal and Social Issues
2012 - Wydawnictwa AGH | Studia Humanistyczne/Studia Humanistyczne AGH
Tamara Cvijić, Matej Horvat, Jakob Plahutnik, Ana Golob, Jaka Marušič,
Development of novel therapeutic proteins and biosimilars requires a thorough understanding of the relationship between their structure and function. Particularly, how IgG glycosylation affects its effector functions is a point increasingly underscored in guidelines by the World Health Organization and regulatory agencies. Our results show that just a 1% decrease in Fc fucosylation can lead to a more than 25% increase in antibody-dependent cell-mediated cytotoxicity. The intercorrelated nature of ...
Tópico(s): Glycosylation and Glycoproteins Research
2024 - Landes Bioscience | mAbs
Kanika Dharmayat, Antonio J. Vallejo‐Vaz, C. Stevens, Julia Brandts, Alexander R.M. Lyons, Urh Grošelj, Marianne Abifadel, Carlos A. Aguilar‐Salinas, Khalid F. AlHabib, Mutaz Al-Khnifsawi, Wael Almahmeed, Fahad Alnouri, Rodrigo Alonso, Khalid Al‐Rasadi, Tester F. Ashavaid, Maciej Banach, Sophie Béliard, Christoph J. Binder, Mafalda Bourbon, Krzysztof Chlebus, Pablo Corral, Diogo Cruz, Olivier Descamps, Euridiki Drogari, Ronen Durst, М. В. Ежов, Jacques Genest, Mariko Harada‐Shiba, Kirsten B. Holven, Steve E. Humphries, Weerapan Khovidhunkit, Katarina Lalić, Ulrich Laufs, Evangelos Liberopoulos, Jeanine E. Roeters van Lennep, Marcos M. Lima-Martínez, Jie Lin, Vincent Maher, Winfried März, André R. Miserez, Olena Mitchenko, Hapizah Nawawi, Andrie G. Panayiotou, György Paragh, Arman Postadzhiyan, Ashraf Reda, Željko Reiner, Ximena Reyes, Fouzia Sadiq, Amirhossein Sahebkar, Heribert Schunkert, Aleksandr B. Shek, E.S.G. Stroes, Ta‐Chen Su, Subramaniam Tavintharan, Andrey V. Susekov, Alejandra Cárdenas, Thanh Huong Truong, Alexandros D. Tselepis, Branislav Vohnout, Luya Wang, Shizuya Yamashita, Ahmad Al‐Sarraf, Nasreen Al-Sayed, Kairat Davletov, Bambang Dwiputra, Dan Gaiţă, Meral Kayıkçıoğlu, Gustavs Latkovskis, Adéle Marais, Anne Thushara Matthias, Erkin М Мirrakhimov, Børge G. Nordestgaard, Žaneta Petrulionienė, Belma Pojskić, Wilson E. Sadoh, Myra Tilney, Brian Tomlinson, Anne Tybjærg‐Hansen, Margus Viigimaa, Alberico L. Catapano, Tomáš Freiberger, G. Kees Hovingh, Pedro Mata, Handrean Soran, Frederick J. Raal, Gerald F. Watts, Laura Schreier, Virginia Bañares, Susanne Greber‐Platzer, Margot Baumgartner-Kaut, Charlotte de Gier, Hans Dieplinger, Florian Höllerl, Reinhold Innerhofer, Daniela Karall, Julia Lischka, Bernhard Ludvik, Martin Mäser, Sabine Scholl‐Bürgi, Alexandra Thajer, Hermann Toplak, Fabian Demeure, Ann C. Mertens, Jean‐Luc Balligand, Xavier Stéphenne, Étienne Sokal, Ivo Petrov, Assen Goudev, Fedya Nikolov, Snejana Tisheva, Yoto Yotov, Ivajlo Tzvetkov, Robert A. Hegele, Daniel Gaudet, Liam R. Brunham, Isabelle L. Ruel, Brian W. McCrindle, Ada Cuevas, Dražen Perica, Phivos Symeonides, Efstratios Trogkanis, Andreas Kostis, Andreas L. Ioannou, Angeliki Mouzarou, Anthoula Georgiou, Andreas Stylianou, George Miltiadous, Paris Iacovides, Constantinos Deltas, Michal Vrablı́k, Zuzana Urbanová, Pavel Ješina, Lukáš Tichý, J Hyánek, Jana Dvořáková, Jana Čepová, Josef Sykora, Kristyna Buresova, Michal Pipek, Eva Pistkova, Ivana Bartkova, Astrid S ulakova, Lenka Ťoukálková, Michaela Špenerová, Jan Malý, Marianne Benn, Ahmed Bendary, Atef Elbahry, Jean Ferrières, Dorota Ferrières, Noël Peretti, Éric Bruckert, Antonio Gallo, René Valéro, Florian Mourre, Karine Aouchiche, Rachel Reynaud, Patrick Tounian, Julie Lemale, Franck Boccara, Philippe Moulin, Sybil Charrières, Mathilde Di Filippo, Bertrand Cariou, François Paillard, Caroline Dourmap, A. Pradignac, Bruno Vergès, Isabelle Simoneau, Michel Farnier, Yves Cottin, Cécile Yelnik, R. Hankard, François Schiele, Vincent Durlach, Ariane Sultan, Alain Carrié, Jean‐Pierre Rabès, Veronika Sanin, Raphael Schmieder, Sara Ates, Christos V. Rizos, Ioannis Skoumas, Κωνσταντίνος Τζιόμαλος, Lοukianos S. Rallidis, Vasilios Kotsis, Michael Doumas, Emmanouil Skalidis, Genovefa Kolovou, Vana Kolovou, Anastasia Garoufi, Iosif Koutagiar, Georgios Polychronopoulos, Estela Kiouri, Christina Antza, E. Zacharis, Achilleas Attilakos, George Sfikas, Charalambos Koumaras, Panagiotis Anagnostis, Georgia Anastasiou, Georgé Liamis, P Adamidis, Haralambos Milionis, Vaia Lambadiari, Stella Stabouli, Theodosios D. Filippatos, Vasiliki Mollaki, Anastasia Tsaroumi, Frida Lamari, Pavlos Proyias, Mariann Harangi, Lakshmi Lavanya Reddy, Swarup A.V. Shah, Chandrashekhar K. Ponde, Jamshed Dalal, J.P.S. Sawhney, Ishwar C. Verma, Susan Hosseini, Tannaz Jamialahmadi, Mohammed Alareedh, Foaad Shaghee, Sabah Hasan Rhadi, Maryam Abduljalal, Sarmad Alfil, Huda Kareem, Hofit Cohen, Eran Leitersdorf, Daniel Schurr, Shoshi Shpitzen, Marcello Arca, Maurizio Averna, Stefano Bertolini, S. Calandra, Patrizia Tarugi, Manuela Casula, Federica Galimberti, Marta Gazzotti, Elena Olmastroni, Riccardo Sarzani, Claudio Ferri, Elena Repetti, Francesco Giorgino, Patrizia Suppressa, Antonio Bossi, Claudio Borghi, Sandro Muntoni, Francesco Cipollone, Roberto Scicali, Arturo Pujia, Angelina Passaro, Martina Berteotti, Valerio Pecchioli, Livia Pisciotta, Giuseppe Mandraffino, Fabio Pellegatta, Giuliana Mombelli, Adriana Branchi, A.M. Fiorenza, Cristina Pederiva, José Pablo Werba, Gianfranco Parati, Fabio Nascimbeni, Lorenzo Iughetti, Giuliana Fortunato, Raimondo Cavallaro, Gabriella Iannuzzo, Paolo Calabrò, Angelo B. Cefalù, Maria Elena Capra, Alberto Zambon, Matteo Pirro, Francesco Sbrana, Chiara Trenti, Ilenia Minicocci, Massimo Federici, Maria Del Ben, Paola Sabrina Buonuomo, Simona Moffa, A. E. Pípolo, Nadia Citroni, Ornella Guardamagna, Salvatore Lia, Andrea Benso, Gianni Biolo, Lorenzo Maroni, Alessandro Lupi, Luca Bonanni, Elisabetta Rinaldi, Maria Grazia Zenti, Daisaku Masuda, Linda Mahfouz, S Jambart, Carine Ayoub, Youmna Ghaleb,
Summary Background Approximately 450 000 children are born with familial hypercholesterolaemia worldwide every year, yet only 2·1% of adults with familial hypercholesterolaemia were diagnosed before age 18 years via current diagnostic approaches, which are derived from observations in adults. We aimed to characterise children and adolescents with heterozygous familial hypercholesterolaemia (HeFH) and understand current approaches to the identification and management of familial hypercholesterolaemia to ...
Elsevier BV
George L. Bakris, Manish Saxena, Anil Gupta, Fadi Chalhoub, Jong-Tae Lee, Daniel Stiglitz, Nune Makarova, Nitender Goyal, Weinong Guo, Dion Zappe, Akshay S. Desai, George Carr, Christopher Case, Lauren Hubert Jaeger, Lisa Bruns, Ginger Stratman, Christy Kidwell, Suzin Cunningham, Nicholas Piccone, Mordecai Klein, María Rodríguez Acuña, Srishti Arora, Amanda Clark, Ezekiel Fink, Cesia Garcia, Astrid George, Elizabeth Gray, C. M. Mahaffey, Maria McElheney, Elizabeth Reyes Ortíz, Sunny Saumya, Adele Wallace, Jenelle Watts, Daisy Zambrana, Douglas Denham, Erica Rivera, Ayoade Avworo, Parke Hedges, Corri Fancher, Rafik Abadier, Lisa Braud, Laura Cenatiempo, Amanda Elwood, Linda Esther Gray, Peter Gray, Kimberly Griffin, Hammad-ur-rehman Khan, Nadeen Kongquee, Susan LaTorraca, Tiffany Liles, J. M. Livingston, Marc Lozano, Amy Lupton, Tiffany Lyles, Deana Mardini, Susan Moss, K. Packer, Aakash Patel, Tina Russ, Brianna Scinicariello, Shannon Trull, Blair Warren, Fadi Chalhoub, Susan Angel, Sujeeta Dhakhwa, Ivy Gabon, Leticia Goodwin, Nandita Joshi Jones, Mark Joyce, Niketa Kamble, Brooke McFall, Rose Githiiyu, Leticia Robinson, Lauren A. Tomlinson, Emir Hadziavdic, Stephany Vega, James H. Greenwald, Jessica Achan, L Poyatos Ruiz, Mehwish Buksh, Omkar Chauhan, Elisee Derisseau, Faith Ferguson, Monika Grabowski, Larisa Gumerova, Miriam Hernandez, Kenna Martin, Krina K. Patel, Dibnain Nanda, José Garcı́a Pérez, Corey Ribeca, Elijah Rueda, Ana Sordi Guth, N. Modh Zaki, Ebony Green, Nina Mondoc, Robert Buynak, Stephanie Andree, Martha Brazinsky, L Fuller, Nikki Green, Hannade Ibrahim, Marilyn Idowu, Miranda Lee, Erica Lewis, Goldie Luna, Rachel McNeal, Alicia Owens, Consuelita Perez, Taryn Petty, Megan Smith, Patricia Volom, Angela Webb, Destiny Williams, Mark Yarosz, Nashwa Gabra, Nabil Andrawis, Amy Aziz, Magda Hanna, Josefina Manalo, Victoria Helow, William Davila, Sydney Crisp, Yvonne L. Douglas, Jenna Everett, Sarah Graham, Ellen Heard, Michelle Mackie, Suman Mayer, Lisa Moore, Stephanie Resurreccion, Jennifer Sidey, Michael C. Stephens, Mary Strickland, Dawn Van Camp, Stephanie Wilder, Anne Møller Witt, Jolenne Wolfer, L. Groben, Lindsey Aeschliman, Emily Audlehelm, Casey Fitz, Judi Greene, Emily Hippen, Michelle S. Johnson, Allan P. Latcham, Shekela Leggett, K. Link, J. E. J. Lovell, Kourtney Marlow, Cynthia Marske, Kelsey N. Maxwell, Charlotte Newsom-Henderson, Darcie Oelberg, Kathleen Ollinger, Rebecca Risius, Kylea Ryther, Alyssa Waddell, Tyler Zellerman, Martin Albornoz Santofimio, Stephen Plantholt, Morgan Beatty, Heather Blubaugh, Tina Bootz, Jeffrey A. Cole, Jasmine Conners, Vicki J. Coombs, Chloe Goddard, Carlos Ince, Gail Kiddy, Barbara Klimuszka, Frederick A. Kuhn, David Lowry, Patricia Previll, Stephanie Rioux, Jasmine Scott, B. A. Shepherd, Amy Urffer, Sarah L. Smiley, Gregg Lucksinger, Allison Alvord, J.D. Anderson, Courtney Block, Ashley S. M. Chan, John Delgado, K. R. Frost, Levi Gadbois, Danuel Hamlin, Sarah Johnson, Vivianna Juncal, Kary Kelly, Emily Kelly, Lilly Kelly, Avery Kerwin, Audrey Kuehl, Jaleh Ostovar, Ryan Rackley, George J. M. Rocha, L.B. Sandberg, Sarah Sheghewi, Tiffany M. Smith, Ben Taucher, Cecilia A. Vasquez, Francisca Villa Rodriguez, Jay Weisbart, Veronica Wescom, Keenan Williams, Jeffrey S. Overcash, Angela Anorve, Hunter Asmann, Gordon Bovee, Laura Castillo, Hanh Chu, Jordan Coslet, Allison Davis, Mary Dinan, Amanda Dubbula, Jacob Esparza, Ann Foster, Andrea Arnaiz García, Jessica Gonzales, Lizette Gonzalez, Pat Kappen, Allison Kornblatt, Brandon Lauderdale, Kia Lee, Sylvia Lindholm, Ashliegh Lindsay, Luis Llanos Gomez, Adrienna Marquez, Catherine Meza, Shandel Odom, Makenna Orel, Shanna Paselio, Samuel Penziner, Helen Pu, Kimberly Quillin, César E. Ramírez, Roxanna Ramirez, Mônica Santos Salgado, Marcy Shores, Raquel Taitingfong, Jennifer Tande, Van Tuiletufuga, Katrina Tyler, Linda Vega, Karla Zepeda, Corey L. Anderson, Nikki Carhill, Benjamin Clark, Lisa Dean, Naomi Devine, Sophia DiPeri, G. Espinal, Ronald E. Hawkins, Gabriela Irra, Angela Ledezma, Georgina Lopez-Wood, Micaela Luna, Wael Mansour, Tasha Marriott, Ashley Perez, James M. Ramsey, W. Jay Reedy, Hannah Spinks, Cecilia Tanori, David Tatelbaum, Rudy Vasquez, K.D. Vasquez, Jori Vigil, Isabel Worthen, Devin Yu, Jessica N. Zuniga, Patrick Dennis, L.D.L.A. Alvarado, Armand Cox, Victoria Cullaro, John Dunbar, Katherine Giorlando, London Hannan, Tyler Hastings, Geoff Hoskins, Emily Krambeck, J Laurent, Olga Michelle Martinez, Reggie Mister, Autumn Moss, Margaret Muli, Nicolette Quinn, Brittany Reed, Adam Robinson, Casey Saavedra, Caitlin Simon, Derek Smith, Dylan Touchet, Annie Wright,
Angiotensinogen is the most upstream precursor of the renin-angiotensin-aldosterone system, a key pathway in blood pressure (BP) regulation. Zilebesiran, an investigational RNA interference therapeutic, targets hepatic angiotensinogen synthesis.
American Medical Association
Alen Ajanović, Jaka Konda, Gašper Fele-Žorž, Anton Gradišek, Matjaž Gams, Ana Peterlin, Karolina Počivavšek, Mojca Matičič,
We present a web application to detect risks related to sexually transmitted infections (STIs). The application works as a questionnaire about sexual behaviour and risk factors for STIs and, based on the answers, calculates the risk of being infected. The application also works as an informational tool with educating about STI and prevention. It uses a combination of approaches from computer science and psychology to deliver a usable, clean interface with which the user feels safe.
Tópico(s): Focus Groups and Qualitative Methods
2017 - IOS Press | Informatica
Amany Elshorbagy, Alexander R.M. Lyons, Antonio J. Vallejo‐Vaz, C. Stevens, Kanika Dharmayat, Julia Brandts, Alberico L. Catapano, Tomáš Freiberger, G. Kees Hovingh, Pedro Mata, Frederick J. Raal, Raúl D. Santos, Handrean Soran, Gerald F. Watts, Marianne Abifadel, Carlos A. Aguilar-Salinas, Khalid F. AlHabib, Mutaz Al-Khnifsawi, Wael Almahmeed, Rodrigo Alonso, Khalid Al‐Rasadi, Ahmad Al‐Sarraf, Tester F. Ashavaid, Maciej Banach, Christoph J. Binder, Mafalda Bourbon, Liam R. Brunham, Krzysztof Chlebus, Pablo Corral, Diogo Cruz, Kairat Davletov, Olivier Descamps, М. В. Ежов, Dan Gaiţă, Urh Grošelj, Mariko Harada‐Shiba, Kirsten B. Holven, Meral Kayıkçıoğlu, Weerapan Khovidhunkit, Katarina Lalić, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Marcos M. Lima-Martínez, Jie Lin, Vincent Maher, Adéle Marais, Winfried März, Erkin М Мirrakhimov, André R. Miserez, Olena Mitchenko, Hapizah Nawawi, Børge G. Nordestgaard, Andrie G. Panayiotou, György Paragh, Žaneta Petrulionienė, Belma Pojskić, Arman Postadzhiyan, Ashraf Reda, Željko Reiner, Ximena Reyes, Fouzia Sadiq, Wilson E. Sadoh, Heribert Schunkert, Aleksandr B. Shek, Erik S.G. Stroes, Ta‐Chen Su, Subramaniam Tavintharan, Andrey V. Susekov, Myra Tilney, Brian Tomlinson, Thanh‐Huong Truong, Alexandros D. Tselepis, Anne Tybjærg‐Hansen, Alejandra C. Vázquez, Margus Viigimaa, Branislav Vohnout, Luya Wang, Shizuya Yamashita, Marcello Arca, Maurizio Averna, Laura Schreier, Jing Pang, Christoph Ebenbichler, Hans Dieplinger, Reinhold Innerhofer, Yvonne Winhofer-Stöckl, Susanne Greber‐Platzer, Konstantin A. Krychtiuk, Walter S. Speidl, Hermann Toplak, Kurt Widhalm, Thomas M. Stulnig, Kurt Huber, Florian Höllerl, Gersina Rega‐Kaun, Lucas Kleemann, Martin Mäser, Sabine Scholl‐Bürgi, Christoph Säly, Florian Mayer, Alexandra Sperone, Chloé Tanghe, A Gérard, L. Pojskic, Ibrahim Šišić, Azra Durak-Nalbantić, Malik Ejubović, Cinthia E. Jannes, Alexandre C. Pereira, José Eduardo Krieger, Ivo Petrov, Assen Goudev, Fedya Nikolov, Snejana Tisheva, Yoto Yotov, Ivajlo Tzvetkov, Alexis Baass, Jean Bergeron, Sophie Bernard, Diane Brisson, Liam R. Brunham, Lubomira Cermakova, Patrick Couture, Gordon A. Francis, Daniel Gaudet, Robert A. Hegele, Étienne Khoury, G.B. John Mancini, Brian W. McCrindle, Martine Paquette, Isabelle L. Ruel, Iulia Iatan, Ada Cuevas, Xumin Wang, Kang Meng, Xiantao Song, Qiang Yong, Tao Jiang, Ziyou Liu, Yanyu Duan, Jing Hong, Pucong Ye, Yan Chen, Jianguang Qi, Zesen Liu, Yuntao Li, Chaoyi Zhang, Jie Peng, Ya Yang, Wei Yu, Qian Wang, Hui Yuan, Shitong Cheng, Long Jiang, Mei Chong, Jian Jiao, Yue Wu, Wenhui Wen, Liyuan Xu, Ruiying Zhang, Yichen Qu, Jianxun He, Xuesong Fan, Zhenjia Wang, Elaine Chow, Ivan Pećin, Dražen Perica, Phivos Symeonides, Michal Vrablı́k, Richard Češka, Vladimír Soška, Lukáš Tichý, Věra Adámkova, J Franeková, Renata Cífková, Pavel Kraml, Katerina Vonaskova, Jana Čepová, Magdaléna Dušejovská, Lenka Pavlíčková, V. Bláha, Hana Rosolová, Barbora Nussbaumerová, Roman Cibulka, H Vaverková, Ľubica Cibičková, Zdenka Krejsova, Katerina Rehouskova, Pavel Malina, Milena Budikova, Vaclava Palanova, Lucie Solcova, Alena Lubasova, Helena Podzimkova, Juraj Bujdák, Jiří Veselý, Marta Jordanova, Tomáš Šálek, Robin Urbánek, Stanislav Zemek, Ján Lacko, Hana Halamkova, Sona Machacova, Sarka Mala, Eva Cubova, Katerina Valoskova, Lukas Burda, Marianne Benn, Ahmed Bendary, Ihab Daoud, Sameh Emil, Atef Elbahry, Samir Rafla, Osama Sanad, Ghada Kazamel, Dr Mohamed Ashraf, Mohamed Sobhy, Amro El-Hadidy, Mohamed Abdoul Shafy, Saif Uldun Mostfa Kamal, Mohamed Bendary, Grete Talviste, Jutta Christmann, Alexander Dressel, Felix Fath, Chiara Ferraro, Lydia Frenzke, Alica Gopon, Isabel Klein, Dominika Pienkowska, Tobias Sietmann, Antonia Sonntag, Omar Adjan, Philipp Bahrmann, Andrea Baessler, Rasmus Barkowski, Raffi Beckerdjian, Christina M. Berr, Andreas L. Birkenfeld, Gereon Böll, Avisha Carstensen, Ilya Demuth, Holger Finkernagel, Ioanna Gouni‐Berthold, Harry Hahmann, Michael Hamerle, Julian Halder, M Heide, Ulrich Julius, Ursula Kassner, Julius L. Katzmann, Anja Kirschbaum, Gerald Klose, Stephanie Könemann, Christel König, Wolfgang König, Bernhard Krämer, Gerrit Kuprat, Ann‐Cathrin Koschker, Bernhard Krämer, Özlem Kilic, Ulrich Laufs, G Lindenmeier, Iris van de Loo, Babette Lorenz, E Lorenz, Birgit Löhr, Johanna McChord, Mariya Maslarska, Heiko Methe, Martin Merkel, Zineb Moussaoui, Irina Müller-Kozarez, Christoph B. Olivier, Peter Ong, Britta Otte, Klaus G. Parhofer, Carl‐Joachim Partsch, Michael Paulus, Sinan Pehlivanli, Tobias Pflederer, Thomas Pusl, Veronika Richter, Stefanie Rosner, Veronika Sanin, Sebastian Schäfer, Christoph Schäfer, Ulrike Schatz, Stephan H. Schirmer, Christine Schmidt, Werner Seeger, Snezna Sisovic, Antje Spens, Ksenija Stach Jablonski, Alexander Stadelmann,
Statins are the cornerstone treatment for patients with heterozygous familial hypercholesterolaemia but research suggests it could increase the risk of type 2 diabetes in the general population. A low prevalence of type 2 diabetes was reported in some familial hypercholesterolaemia cohorts, raising the question of whether these patients are protected against type 2 diabetes. Obesity is a well known risk factor for the development of type 2 diabetes. We aimed to investigate the associations of known ...
Elsevier BV
Aleksandra Martinovska-Stojcheska, Ivana Janeska Stamenkovska, Ana Kotevska, Dragi Dimitrievski, Jaka Žgajnar,
Farm economic performance measuring is important for farm management purposes and for assessing the impact of agricultural policy measures. Efficiency studies enable assessment of farm performance since highly efficient farms are considered to have higher potential for operating in a changing economic and technological environment. The aim of this paper is to assess the technical efficiency of vegetable farms in North Macedonia, utilising Data Envelopment Analysis, as a non-parametric approach estimating ...
Tópico(s): Sustainable Agricultural Systems Analysis
2021 - University of Zagreb, Faculty of Agriculture | Journal of Central European Agriculture