Maria Lobo, Ana Teles, Margarida Barão da Cunha, Joaquim Henriques, Ana Mafalda Lourenço, Francisco Antunes, Olga Matos,
... Lisboa, PortugalSearch for more papers by this authorANA MAFALDA LOURENCO, ANA MAFALDA LOURENCO Clinica Veterinária São Macário–Lazurim, Universidade ... Lisboa, PortugalSearch for more papers by this authorANA MAFALDA LOURENCO, ANA MAFALDA LOURENCO Clinica Veterinária São Macário–Lazurim, Universidade de ...
Tópico(s): Vector-Borne Animal Diseases
2003 - Wiley | Journal of Eukaryotic Microbiology
Edward Jenkins, Markus Körbel, Caitlin O’Brien‐Ball, James McColl, Kevin Y. Chen, Mateusz Kotowski, Jane Humphrey, Anna H. Lippert, Heather Brouwer, Ana Mafalda Santos, Steven F. Lee, Simon J. Davis, David Klenerman,
Abstract T cells use finger-like protrusions called ‘microvilli’ to interrogate their targets, but why they do so is unknown. To form contacts, T cells must overcome the highly charged, barrier-like layer of large molecules forming a target cell’s glycocalyx. Here, T cells are observed to use microvilli to breach a model glycocalyx barrier, forming numerous small (<0.5 μm diameter) contacts each of which is stabilized by the small adhesive protein CD2 expressed by the T cell, and excludes large proteins ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2023 - Nature Portfolio | Nature Communications
Daniel W. Bayless, Chung-ha O. Davis, Renzhi Yang, Yichao Wei, Vinicius Miessler de Andrade Carvalho, Joseph R. Knoedler, Taehong Yang, Oscar Livingston, Akira Lomvardas, Gabriela J. Martins, Ana Mafalda Vicente, Jun Ding, Liqun Luo, Nirao M. Shah,
Male sexual behavior is innate and rewarding. Despite its centrality to reproduction, a molecularly specified neural circuit governing innate male sexual behavior and reward remains to be characterized. We have discovered a developmentally wired neural circuit necessary and sufficient for male mating. This circuit connects chemosensory input to BNSTprTac1 neurons, which innervate POATacr1 neurons that project to centers regulating motor output and reward. Epistasis studies demonstrate that BNSTprTac1 ...
Tópico(s): Receptor Mechanisms and Signaling
2023 - Cell Press | Cell
Ana Tadeu, Susana A. Ribeiro, Josiah Johnston, I. Goldberg, Dietlind L. Gerloff, William C. Earnshaw,
... for centromere organization, chromosome alignment and cytokinesis Ana Mafalda Baptista Tadeu Ana Mafalda Baptista Tadeu Wellcome Trust Centre for Cell ... Search for more papers by this author Ana Mafalda Baptista Tadeu Ana Mafalda Baptista Tadeu Wellcome Trust Centre for Cell Biology, ... for more papers by this author Author Information Ana Mafalda Baptista Tadeu1,2, Susana Ribeiro1, Josiah Johnston3, Ilya ...
Tópico(s): Genomics and Chromatin Dynamics
2008 - Springer Nature | The EMBO Journal
Mariana Fonseca, Ana Mafalda Matos,
Three-dimensional Cementitious materials Printing (3DCP) is a cutting-edge technology for the construction industry. Three-dimensional printed buildings have shown that a well-developed automated technology can foster valuable benefits, such as a freeform architectural design without formworks and reduced human intervention. However, scalability, commercialization and sustainability of the 3DPC technology remain critical issues. The current work presents the ecological fragility, challenges and opportunities ...
Tópico(s): BIM and Construction Integration
2023 - Multidisciplinary Digital Publishing Institute | Materials
Patrícia D. Nunes, Ana Ferreira, João F. Pinto, Annette Bauer‐Brandl, Martin Brandl, João Henriques, Ana Mafalda Paiva,
Along with the increasing demand for complex formulations comes the need for appropriate in vitro methodologies capable of predicting their corresponding in vivo performance and the mechanisms controlling the drug release which can impact on in vivo drug absorption. In vitro dissolution-permeation (D/P) methodologies that can account for the effects of enabling formulations on the permeability of drugs are increasingly being used in performance ranking during early development stages. This work comprised ...
Tópico(s): Drug Transport and Resistance Mechanisms
2023 - Elsevier BV | European Journal of Pharmaceutical Sciences
Verónica Ferreira, Pedro M. Raposeiro, Ana Pereira, Ana Mafalda Cruz, Ana C. Costa, Manuel A. S. Graça, Vítor Gonçalves,
Summary Leaf litter decomposition is an important process in many streams. The flow of carbon and nutrients to higher trophic levels generally depends on litter characteristics and environmental conditions, and is driven by the activities of microbes and invertebrate shredders. However, little is known about what drives litter decomposition in oceanic islands, where invertebrate communities are species‐poor. In this study, we assessed the relative importance of litter quality and environmental conditions ...
Tópico(s): Marine Biology and Ecology Research
2016 - Wiley | Freshwater Biology
Nicole Pedro, Cláudio Silva, Ana C. Magalhães, Bruno Cavadas, Ana Mafalda Rocha, Ana C. Moreira, Maria Salomé Gomes, Diogo Silva, Joana Sobrinho‐Simões, Angélica Ramos, Maria João Cardoso, Rita Filipe, Pedro Palma, Filipa Ceia, Susana Pereira Silva, João Tiago Guimarães, António Sarmento, Verónica Fernandes, Luı́sa Pereira, Margarida Tavares,
A few molecularly proven severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cases of symptomatic reinfection are currently known worldwide, with a resolved first infection followed by a second infection after a 48 to 142-day intervening period. We report a multiple-component study of a clinically severe and prolonged viral shedding coronavirus disease 2019 (COVID-19) case in a 17-year-old Portuguese female. She had two hospitalizations, a total of 19 RT-PCR tests, mostly positive, and criteria ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - Multidisciplinary Digital Publishing Institute | Microorganisms
Ana F. Rodrigues, Ana Mafalda Santos, Ana M. Ferreira, Roberta Marino, Esmeralda Barreira, José Manuel Cabeda,
Tópico(s): Viral gastroenteritis research and epidemiology
2019 - Springer Science+Business Media | Food and Environmental Virology
João Pedro Aguiar, Ana Mafalda Brito, Ana Paula Martins, Hubert G. M. Leufkens, Filipa Alves da Costa,
What is known and objective In the last decades, many lists have been developed to screen for inappropriate prescribing. However, information on which potentially inappropriate medications (PIMs) could increase the cardiovascular risk in the elderly is not objectively presented. This review aimed to identify and quantify those PIMs by extracting information from published PIM-lists. Methods In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement (PRISMA), ...
Tópico(s): Pharmaceutical Economics and Policy
2019 - Wiley | Journal of Clinical Pharmacy and Therapeutics
Delminda Moura, Selma Gabriel, Sofia Gamito, Rui Santos, E. Zugasti, Larissa A. Naylor, Ana Gomes, Ana Mafalda Tavares, Ana Luísa Martins,
Bioerosion on rocky shores has been frequently reported as an important mechanism in coastal evolution, with less attention focussed on determining the bioprotective role organisms may have in mediating coastal erosion. This work aims, for the first time, to provide an integrated assessment of both traversing microerosion meter (TMEM) downwearing rates and activity of intertidal organisms on two carbonate shore platforms in southern Portugal. Paired substations positioned on the same substrate but ...
Tópico(s): Coral and Marine Ecosystems Studies
2012 - Elsevier BV | Continental Shelf Research
Vânia G. da Glória, Mafalda Martins de Araújo, Ana Mafalda Santos, Rafaela L. Silva, Sérgio F. de Almeida, Alexandre M. Carmo, Alexandra Moreira,
The T cell-surface glycoprotein CD6 is a modulator of cellular responses and has been implicated in several autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and psoriasis. During Ag presentation, CD6 is targeted to the immunological synapse in a ligand binding-dependent manner, in which CD6 domain 3 directly contacts CD166, expressed on the APC. T cell activation results in the induction of CD6Δd3, an alternatively spliced isoform that lacks the ligand-binding domain and thus ...
Tópico(s): T-cell and B-cell Immunology
2014 - American Association of Immunologists | The Journal of Immunology
Miguel G. Matias, Cátia Lúcio Pereira, Pedro M. Raposeiro, Vítor Gonçalves, Ana Mafalda Cruz, Ana C. Costa, Miguel B. Araújo,
Following environmental changes, communities disassemble and reassemble in seemingly unpredictable ways. Whether species respond to such changes individualistically or collectively (e.g. as functional groups) is still unclear. To address this question, we used an extensive new dataset for the lake communities in the Azores' archipelago to test whether: 1) individual species respond concordantly within trophic groups; 2) trophic groups respond concordantly to biogeographic and environmental gradients. ...
Tópico(s): Plant and animal studies
2016 - Wiley | Oikos
Marta I. Oliveira, Carine M. Gonçalves, Mafalda Pinto, Stéphanie Fabre, Ana Mafalda Santos, Simon F. Lee, M. Castro, Raquel J. Nunes, Rita Barbosa, Jane R. Parnes, Chao Yu, Simon J. Davis, Alexandra Moreira, Georges Bismuth, Alexandre M. Carmo,
Abstract The T lineage glycoprotein CD6 is generally considered to be a costimulator of T‐cell activation. Here, we demonstrate that CD6 significantly reduces early and late T‐cell responses upon superantigen stimulation or TCR triggering by Abs. Measuring calcium mobilization in single cells responding to superantigen, we found that human T cells expressing rat CD6 react significantly less well compared with T cells not expressing the exogenous receptor. When the cytoplasmic domain of rat CD6 was ...
Tópico(s): Immune Response and Inflammation
2011 - Wiley | European Journal of Immunology
Ana Coelho, Mafalda Laranjo, Ana Cristina Gonçalves, Anabela Paula, Siri Paulo, Ana Margarida Abrantes, Francisco Caramelo, Manuel Marques Ferreira, Mário Jorge Silva, Eunice Carrilho, Maria Filomena Botelho,
Tópico(s): Photodynamic Therapy Research Studies
2019 - Springer Science+Business Media | Odontology
Pedro M. Raposeiro, Ana Mafalda Cruz, Samantha Jane Hughes, Ana C. Costa,
Azorean freshwater invertebrates: Status, threats and biogeographic notes This paper presents an updated catalogue of the freshwater invertebrates of the Azores archipelago and reviews the published records to account for the current taxonomic status and changes in the nomenclature of the listed taxa. The number of freshwater invertebrate species that has been recorded in the Azores has risen sharply throughout the 20th century to 241 species based on field collections and the identification by ...
Tópico(s): Fish Ecology and Management Studies
2012 - | Limnetica
Maria I. L. Soares, Ana Brito, Mafalda Laranjo, Ana Margarida Abrantes, Maria Filomena Botelho, J.A. Paixão, Α. Matos Beja, Manuela Ramos Silva, Teresa M. V. D. Pinho e Melo,
Tópico(s): Biochemical and Molecular Research
2010 - Elsevier BV | European Journal of Medicinal Chemistry
Ana Assunção, Ana Mafalda Matos, Ana M. Rosa da Costa, António Candeias, María Clara Costa,
The Platinum Group Metals (PGM) are rare in the Earth's crust and in the past years their use had a considerable expansion limiting their availability, which justifies PGM's high commercial value and demand. Therefore, PGM recovery from secondary sources is very important from both economic and environmental points of view. In recent years, several methods for PGM removal have been investigated. Our research group has been studying the removal/recovery of PGM using both chemical (liquid–liquid extraction) ...
Tópico(s): Electrochemical Analysis and Applications
2016 - Elsevier BV | Hydrometallurgy
Ana Mafalda Matos, João M. P. Q. Delgado, Ana Sofia Guimarães,
Energy-poverty (EP) must be considered an energy-related issue since buildings are a central part of people’s daily lives. Thus, it has an important role in energy-related policy implementation. Even though the European Union (EU) has endorsed general energy efficiency through the Energy Efficiency Directive and Energy Performance of Buildings Directive recast, it was the Clean Energy Package for all Europeans that clearly highlighted EP. The growing concerns with EP have also been emphasised in subsequent ...
Tópico(s): Energy, Environment, and Transportation Policies
2022 - Multidisciplinary Digital Publishing Institute | Energies
Ana Sofia Varanda, Mafalda Santos, Ana Raquel Soares, Rui Vitorino, Patrícia Oliveira, Carla Oliveíra, Manuel A. S. Santos,
Deregulation of tRNAs, aminoacyl-tRNA synthetases (aaRS) or tRNA modifying enzymes, increase the level of protein synthesis errors (PSE) and are associated with several diseases, but the cause-effect mechanisms of these pathologies remain elusive. To clarify the role of PSE in human biology, we have engineered a HEK293 cell line to overexpress a wild type (Wt) tRNASer and two tRNASer mutants that misincorporate serine at non-cognate codon sites. Then, we followed long-term adaptation to PSE of such ...
Tópico(s): RNA modifications and cancer
2019 - Taylor & Francis | RNA Biology
Carlos Miguel Marto, Anabela Paula, Tiago Nunes, M. C. Pimenta, Ana Margarida Abrantes, Ana Salomé Pires, Mafalda Laranjo, Ana Coelho, Helena Donato, Maria Filomena Botelho, Manuel Marques Ferreira, Eunice Carrilho,
Abstract Objectives To compare the treatments used to treat dentin hypersensitivity (DH), based on its efficacy and effect duration. Methods Medline/PubMed, Cochrane Library, EMBASE and ClinicalTrials were searched for articles published between 1 January 2008 and 14 November 2018, in English, Portuguese or Spanish, reporting clinical trials, completed and with results. This systematic review protocol was registered in PROSPERO, number CRD42019121986. Results Seventy‐four randomised clinical trials ...
Tópico(s): Dental materials and restorations
2019 - Wiley | Journal of Oral Rehabilitation
Arménio C. Serra, Marta Piñeiro, Α. Μ. d’A. Rocha Gonsalves, Ana Margarida Abrantes, Mafalda Laranjo, Ana C. Santos, Maria Filomena Botelho,
Brominated and iodinated derivatives of 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin were synthesised directly from the corresponding aldehydes. Photophysical and photochemical properties, singlet oxygen formation quantum yields, photobleaching and log P were measured. Cellular uptake measurements and cytotoxicity assays on WiDr and A375 tumour cell lines were performed. 5,10,15,20-Tetrakis(2-bromo-5-hydroxyphenyl)porphyrin showed the best cytotoxicity with values of IC50 of 113 nM over WiDr cells ...
Tópico(s): Nanoplatforms for cancer theranostics
2008 - Elsevier BV | Journal of Photochemistry and Photobiology B Biology
Ana Salomé Pires, Cláudia R. Marques, João Crispim Encarnação, Ana Margarida Abrantes, A.C. Mamede, Mafalda Laranjo, Ana Cristina Gonçalves, Ana Bela Sarmento‐Ribeiro, Maria Filomena Botelho,
Colorectal cancer is a major health problem worldwide with urgent need for new and effective anti-cancer approaches that allow treating, increasing survival and improving life quality of patients. At pharmacological concentrations, ascorbic acid (AA) exerts a selective cytotoxic effect, whose mechanism of cytotoxicity remains unsolved. It has been suggested that it depends on the production of extracellular hydrogen peroxide, using ascorbate radical as an intermediate. The aim of this study was to ...
Tópico(s): Vitamin D Research Studies
2016 - Elsevier BV | European Journal of Cell Biology
Tatiana Maurício, Daniela Couto, Diana Lopes, Tiago Conde, Rita Pais, Joana Batista, Tânia Melo, Marisa Pinho, Ana S. P. Moreira, Mafalda Trovão, Ana Barros, Helena Cardoso, Joana Silva, Pedro Domíngues, M. Rosário M. Domingues,
The microalga Chlorella vulgaris is a popular food ingredient widely used in the industry, with an increasing market size and value. Currently, several edible strains of C. vulgaris with different organoleptic characteristics are commercialized to meet consumer needs. This study aimed to compare the fatty acid (FA) and lipid profile of four commercialized strains of C. vulgaris (C-Auto, C-Hetero, C-Honey, and C-White) using gas- and liquid-chromatography coupled to mass-spectrometry approaches, and ...
Tópico(s): Aquaculture Nutrition and Growth
2023 - Multidisciplinary Digital Publishing Institute | Foods
Ana Coelho, Anabela Paula, Marta Mota, Mafalda Laranjo, Ana Margarida Abrantes, Francisco Carrilho, Manuel Marques Ferreira, Mário Silva, Maria Filomena Botelho, Eunice Carrilho,
Objectives Since most of the studies evaluates diabetics on multiple daily injections therapy and continuous subcutaneous insulin infusion may help gain better metabolic control and prevent complications, the objective of this study was to evaluate the prevalence of dental caries, the unstimulated salivary flow rate and the total bacteria load, Streptococcus spp. levels and Lactobacillus spp. levels in saliva and supragingival dental biofilm of type 1 diabetics on insulin pump. Material and Methods ...
Tópico(s): Salivary Gland Disorders and Functions
2018 - UNIVERSIDADE DE SÃO PAULO | Journal of Applied Oral Science
Marta Manso, Ana Mafalda Cardeira, Mara Silva, Agnès Anne Françoise Le Gac Arinto, Sofia Pessanha, Mauro Guerra, Ana Teresa Caldeira, António Candeias, Luísa Carvalho,
Tópico(s): Conservation Techniques and Studies
2014 - Springer Science+Business Media | Applied Physics A
Patrícia Machado, Rui Pereira, Ana Mafalda Rocha, Licínio Manco, Natércia Fernandes, Juliana Miranda, Letícia Ribeiro, Virgı́lio E. do Rosário, António Amorim, Leonor Gusmão, Ana Paula Arez,
The genetic component of susceptibility to malaria is both complex and multigenic and the better-known protective polymorphisms are those involving erythrocyte-specific structural proteins and enzymes. In vivo and in vitro data have suggested that pyruvate kinase deficiency, which causes a nonspherocytic haemolytic anaemia, could be protective against malaria severity in humans, but this hypothesis remains to be tested. In the present study, we conducted a combined analysis of Short Tandem Repeats ( ...
Tópico(s): HIV Research and Treatment
2010 - Wiley | British Journal of Haematology
Natacha Couto, Joana Martins, Ana Mafalda Lourenço, Constança Pomba, Ana Varela Coelho,
The recent emergence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) has complicated considerably the treatment of infections caused by these bacteria. Therefore new treatment strategies are urgently needed, namely through the development of vaccines towards the control of bacterial infections. Our study describes an extensive characterization of the proteome of S. pseudintermedius through a 2-DE MALDI-TOF/TOF approach, followed by SERological Proteome Analysis (SERPA) to identify ...
Tópico(s): Probiotics and Fermented Foods
2015 - Elsevier BV | Journal of Proteomics
Héctor García‐Moreno, Mercedes Prudencio, Gilbert Thomas‐Black, Nita Solanky, Karen Jansen‐West, Rana Hanna Al‐Shaikh, Amanda Heslegrave, Henrik Zetterberg, Magda M. Santana, Luís Pereira de Almeida, Ana Vasconcelos‐Ferreira, Cristina Januário, Jon Infante, Jennifer Faber, Thomas Klockgether, Kathrin Reetz, Mafalda Raposo, Ana F. Ferreira, Manuela Lima, Lüdger Schöls, Matthis Synofzik, Jeannette Hübener‐Schmid, Andreas Puschmann, Sorina Gorcenco, Zbigniew K. Wszołek, Leonard Petrucelli, Paola Giunti,
Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures.To evaluate total tau (t-tau), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and neurofilament light-chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers (n = 143) and controls (n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD-1 platform. Eleven ATXN3 mutation carrier cerebrospinal ...
Tópico(s): DNA Repair Mechanisms
2022 - Wiley | European Journal of Neurology
Ana Ponte, Rolando Pinho, Sónia Fernandes, Adélia Rodrigues, Luís Alberto, João Carlos Silva, Joana Silva, Jaime Rodrigues, Mafalda Sousa, Ana Paula Silva, Luísa Proença, Teresa Freitas, Sónia Leite, João Carvalho,
Clinical and endoscopic remissions constitute the therapeutic goals in ulcerative colitis (UC). Histological healing is currently not a target in UC. This study aims to determine the impact of the definition of endoscopic remission (Mayo endoscopic subscore [MSe] 0-1) and histological activity in the recurrence of UC and recurrence-free survival time.Patients with UC in clinical remission (partial Mayo score ≤ 1) and endoscopic remission (MSe ≤ 1) who underwent colonoscopy with biopsies between March 2010 ...
Tópico(s): Liver Diseases and Immunity
2017 - Oxford University Press | Inflammatory Bowel Diseases