Tópico(s): Latin American rural development
2012 - Elsevier BV | Problemas del Desarrollo Revista Latinoamericana de Economía
Inés López‐Cuenca, Rosa de Hoz, Elena Salobrar‐García, Lorena Elvira‐Hurtado, Pilar Rojas, José A. Fernández‐Albarral, Ana Barabash, Juan J. Salazar, Ana I. Ramı́rez, José M. Ramı́rez,
In this case control study, we examined the retinal thickness of the different layers in the macular region and peripapillary retinal nerve fiber layer (RNFL) with optical coherence tomography (OCT) in healthy cognitive subjects (from 51 to 74 years old) at high genetic risk for developing Alzheimer’s disease (AD). Thirty-five subjects with a family history of Alzheimer disease (AD) (FH+) and ApoE ɛ4 carriers and 29 age-matched control subjects without a family history of AD (FH−) and ApoE ɛ4 non-carriers ...
Tópico(s): Alzheimer's disease research and treatments
2020 - Multidisciplinary Digital Publishing Institute | Journal of Clinical Medicine
Salvador del Saz Salazar, Ana Navarrete-Tudela, José Ramón Alcalá-Mellado, Daniel Carlos del Saz-Salazar,
Tópico(s): Psychological Well-being and Life Satisfaction
2017 - Springer Science+Business Media | Journal of Happiness Studies
Giovanni Andrés Hernández Salazar, Ana María Olaya Pardo,
Esta investigación tiene como objetivo estimar cuantitativamente el efecto de las principales Leyes y Decretos promulgados para el sector cooperativo sobre el crecimiento del mismo en Colombia. La información se construye desde 1933-2014 a nivel Nacional y desde 1980-2014 a nivel departamental (regional). A partir de la estimación de modelos de intervención bajo la metodología ARIMA, se evidencia que el marco legal no he tenido un efecto estadísticamente significativo sobre el crecimiento del sector. ...
Tópico(s): Finance, Taxation, and Governance
2018 - AECOOP Escuela de Estudios Cooperativos | REVESCO Revista de Estudios Cooperativos
Albert Carramiñana, Carlos Ferrando, Ma Carmen Unzueta, Ricard Navarro, Fernando Suárez-Sipmann, Gerardo Tusman, Ignacio Garutti, Marina Soro, Natividad Pozo, Julián Librero, Lucía Gallego, F. Ramasco, J. M. Rabanal, Aurelio Rodríguez, José A. Sastre, J. Martinez, Silvia Coves, Pablo García, Pilar Aguirre-Puig, José Yepes, A. Lluch, Daniel López-Herrera, Sonsoles Leal, Marc Vives, Soledad Bellas, Tania Socorro, Ramón Trespalacios, Claudia J. Salazar, Ana Mugarra, Gilda Cinnella, Savino Spadaro, Emmanuel Futier, Leopoldo Ferrer, María Cabrera, Hélder Ribeiro, Catarina Celestino, Evrim Kücür, Oriol Cervantes, Diego Morocho, Dalia Delphy, Carolina del Valle Ramos, Jesús Villar, Javier Belda,
Objective The aim of this clinical trial is to examine whether it is possible to reduce postoperative complications using an individualized perioperative ventilatory strategy versus using a standard lung-protective ventilation strategy in patients scheduled for thoracic surgery requiring one-lung ventilation. Design International, multicenter, prospective, randomized controlled clinical trial. Setting A network of university hospitals. Participants The study comprises 1,380 patients scheduled for thoracic ...
Tópico(s): Tracheal and airway disorders
2019 - Elsevier BV | Journal of Cardiothoracic and Vascular Anesthesia
Rafael Robayo–Salazar, Ana María Aguirre-Guerrero, Ruby Mejía de Gutiérrez,
The alkali-activated concretes have been attractive as an alternative material to Portland cement-based concrete (OPC), due to their low environmental impact and the good mechanical properties, however, regarding durability exist uncertainties. This article studies the performance to carbonation induced corrosion of the reinforcing steel embedded in an alkali-activated binary concrete (AABC) based on NP (70% by mass) and GBFS (30% by mass). According to the results, AABC has a better carbonation performance ...
Tópico(s): Magnesium Oxide Properties and Applications
2019 - Elsevier BV | Construction and Building Materials
Elena Élez, Chiara Chianese, Enrique Sanz‐García, Erica Martinelli, Alba Noguerido, Francesco M. Mancuso, Ginevra Caratù, Judit Matito, Julieta Grasselli, Claudia Cardone, Riziero Esposito Abate, Giulia Martini, Cristina Santos, Teresa Macarulla, Guillem Argilés, Jaume Capdevila, Ariadna García, Nuria Mulet, Evaristo Maiello, Nicola Normanno, Frederick S. Jones, Josep Tabernero, Fortunato Ciardello, Ramón Salazar, Ana Vivancos,
Despite major advances in the treatment of metastatic colorectal cancer (mCRC), the survival rate remains very poor. This study aims at exploring the prognostic value of RAS ‐mutant allele fraction (MAF) in plasma in mCRC. Forty‐seven plasma samples from 37 RAS ‐mutated patients with nonresectable metastases were tested for RAS in circulating tumor DNA using BEAMing before first‐ and/or second‐line treatment. RAS MAF was correlated with several clinical parameters (number of metastatic sites, hepatic ...
Tópico(s): Genetic factors in colorectal cancer
2019 - Elsevier BV | Molecular Oncology
José J. Navas Palacios, María Dolores Valdés, Maria A. Montalban Pallares, Maria D. Gomez De Salazar, Ana García Marcilla,
Ten cases of T-lymphoblastic lymphoma/leukemia were studied with light and electron microscopy. Cytochemical strains were performed on touch preparations, and mononuclear cell suspensions were tested for spontaneous rosette formation with sheep erythrocytes, C3 receptors, and surface immunoglobulins. The present investigation was performed to evaluate several ultrastructural parameters, mainly the nuclear shape, as diagnostic clues for this group of lymphomas. Characteristic convoluted nuclei were ...
Tópico(s): Immune Cell Function and Interaction
1981 - Wiley | Cancer
Pedro David Delgado‐López, Vicente Martín-Velasco, José Manuel Castilla-Díez, A. Rodríguez-Salazar, Ana Galacho-Harriero, O. Fernández-Arconada,
Neurosurgeons are familiar with chronic subdural haematoma (CSH), a well-known clinical entity, which is usually treated by some modality of trepanation. Despite the excellent outcomes obtained by surgery, complications may occur, some of which may be potentially severe or fatal. Furthermore, up to 25% recurrence rate is reported. The authors present a novel approach to the management of CSH based on the use of dexamethasone as the treatment of choice in the majority of cases. Medical records of ...
Tópico(s): Head and Neck Surgical Oncology
2009 - Elsevier BV | Neurocirugía
Vicent Balanzá‐Martínez, Gabriel Selva, Anabel Martínez‐Arán, Jos Prickaerts, José Salazar, Ana González‐Pinto, Eduard Vieta, Rafael Tabarés‐Seisdedos,
The last decade has witnessed a growing interest in the neuropsychological study of bipolar disorder (BD). This chronic mood disorder is associated with persistent neurocognitive impairments even during periods of euthymia, particularly in the broad domains of attention, verbal memory and executive functions. More interestingly, cognitive dysfunction seems to predict a poorer functional outcome among BD patients and thus represents an important target for future therapies. The aetiology of cognitive ...
Tópico(s): Electroconvulsive Therapy Studies
2009 - Elsevier BV | European Journal of Pharmacology
J. M. Ayres, T. H. Clutton‐Brock,
... Gibbs, Michael Sovic, Diana Amazonas, Hippocrates Chalkidis, David Salazar-Valenzuela, Ana M Moura-Da-Silva Recent lineage diversification in ...
Tópico(s): Fish biology, ecology, and behavior
1992 - University of Chicago Press | The American Naturalist
Alberto Triviño, Rosa de Hoz, Juan J. Salazar, Ana I. Ramı́rez, Blanca Rojas, José M. Ramı́rez,
Tópico(s): Neuroscience and Neuropharmacology Research
2002 - Springer Science+Business Media | Anatomy and Embryology
Maite Álvarez-Álvarez, Luis Galdós, Manuel Fernández Martínez, Fernando Gómez-Busto, Victoria García-Centeno, Caridad Arias-Arias, Carmen Sánchez-Salazar, Ana Belén Rodríguez-Martínez, J.J. Zarranz, Marian M. de Pancorbo,
Although there is considerable evidence implicating apolipoprotein E (ApoE) epsilon4 in the development of the Alzheimer's disease (AD), additional factors are also known to be involved. Thus, an association has been described between C267T polymorphism of the 5-hydroxytryptamine 6 receptor (5-HT(6)) receptor gene and AD. This case-control study analyzes the ApoE and 5-HT(6) receptor polymorphisms in 173 cases and 102 age and sex matched controls from Araba and Bizkaia (The Basque Country, Spain). The ...
Tópico(s): Cholinesterase and Neurodegenerative Diseases
2003 - Elsevier BV | Neuroscience Letters
María José Pérez-Álvarez, Carolina Isiegas, C. Santano, Juan J. Salazar, Ana I. Ramı́rez, A. Triviño, José M. Ramı́rez, Juan Pablo Albar, Enrique J. de la Rosa, Carmen Prada,
Abstract The antigen recognized by the monoclonal antibody 3CB2 (3CB2‐Ag and 3CB2 mAb) is expressed by radial glia and astrocytes in the developing and adult vertebrate central nervous system (CNS) of vertebrates as well as in neural stem cells. Here we identified the 3CB2‐Ag as vimentin by proteomic analysis of human glial cell line U‐87 extracts (derived from a malignant astrocytoma). Indeed, the 3CB2 mAb recognized three vimentin isoforms in glial cell lines. In the human retina, 3CB2‐Ag was expressed ...
Tópico(s): RNA Interference and Gene Delivery
2008 - Wiley | Journal of Neuroscience Research
Beatriz Pardo, Luis Paz‐Ares, Josep Tabernero, Eva Ciruelos, Margarita García, Ramón Salazar, Ana López Martín, Ángeles Blanco Blanco, Antonio Nieto, José Jimeno, Miguel Izquierdo, José Trigo,
A dose-escalation, phase I study evaluated the safety, pharmacokinetics, and efficacy of a weekly 1-h regimen of kahalalide F, a cyclic depsipeptide isolated from the marine mollusk Elysia rufescens, in adult patients with advanced solid tumors and no standard treatment available.Patients received an i.v. 1-h infusion of kahalalide F once weekly until disease progression or unacceptable toxicity. The starting kahalalide F dose was 266 microg/m(2), and dose escalation proceeded based on the worst ...
Tópico(s): Marine Sponges and Natural Products
2008 - American Association for Cancer Research | Clinical Cancer Research
Omar Cantillo‐Barraza, Andrés Gómez‐Palacio, Diego A. Salazar, Ana María Mejía‐Jaramillo, Jaime Calle, Omar Triana‐Chávez,
Information concerning to triatomine diversity and some eco-epidemiologic aspects on Margarita Island has been recorded only from two of the five counties on the island. Knowledge about species habitat and their natural infection is essential to establish the risk for Chagas disease in endemic areas.The distribution of triatomine insect fauna and its infection with Trypanosoma cruzi was described in order to establish and to stratify the risk of Chagas disease transmission.Each of the 5 counties ...
Tópico(s): Trypanosoma species research and implications
2010 - National Institute of Health | Biomédica
Nuria Salazar, Ana G. Binetti, Miguel Gueimonde, Ana Alonso, Pablo Garrido, Carmen González del Rey, C. González, Patricia Ruas‐Madiedo, Clara G. de los Reyes‐Gavilán,
Bifidobacterium animalis subsp. lactis IPLA R1 and Bifidobacterium longum IPLA E44 strains were tested for their safety and ability to modulate the intestinal microbiota in vivo. Chemically simulated gastrointestinal digestion showed considerably lower survival of E44 than R1 strain, the first microorganism also being more sensitive to refrigerated storage in 10% skimmed milk at 4 °C. Harmful glycosidic activities were absent, or at low levels, in the strains R1 and E44. Both strains were sensitive ...
Tópico(s): Clostridium difficile and Clostridium perfringens research
2010 - Elsevier BV | International Journal of Food Microbiology
E. Marcuello, David Páez, Laia Paré, Juliana Salazar, Ana Sebio, E. del Rı́o, Montserrat Baiget,
Infusional fluorouracil/leucovorin (FU/LV) plus irinotecan (FOLFIRI) is one of the standard first-line options for patients with metastatic colorectal cancer (mCRC). Irinotecan is converted into 7-ethyl-10-hydroxycamptothecin (SN-38) by a carboxylsterase and metabolised through uridine diphosphate glucuronosyl transferase (UGT1A1). The UGT1A1*28 allele has been associated with the risk of developing severe toxicities. The present trial was designed to define the maximum tolerated dose according to UGT1A1 ...
Tópico(s): Cancer Treatment and Pharmacology
2011 - Springer Nature | British Journal of Cancer
Alberto J. León, José Antonio Garrote, Alfredo Blanco-Quirós, Carmen Calvo, Luís Fernández-Salazar, Ana Villar, A Barrera, Eduardo Arranz,
Dietary gluten induces an early response in the intestine of coeliac disease patients (CD), within a few hours, and this is driven by high levels of proinflammatory cytokines, including IFNgamma and IL-15, as has been thoroughly shown by gluten stimulation of biopsy explants. Our aim was to identify the immune mediators involved in the long-standing inflammation in untreated CD patients at diagnosis. mRNA and protein levels of TNFalpha, IL-12(p35), IL-12(p40), IL-15, IL-18 and IL-23(p19) were quantified ...
Tópico(s): Whipple's Disease and Interleukins
2006 - Oxford University Press | Clinical & Experimental Immunology
Juan J. Salazar, Ana I. Ramı́rez, Rosa de Hoz, Blanca Rojas, Emilio Muñoz Ruiz, Teresa Tejerina, Alberto Triviño, José M. Ramı́rez,
Endothelial damage in atherosclerosis is characterized by abnormal vascular functionality. Hyperlipidemic patients show alterations in ocular vascularization. However, it is not known whether these alterations are reversible after the lipid profile returns to normal. This study evaluates a rabbit model of hypercholesterolemia, examining the ultrastructural changes in the choroid, and the changes in it after a period of normal blood-cholesterol values induced by a standard diet. Rabbits were divided ...
Tópico(s): Retinal Imaging and Analysis
2006 - Elsevier BV | Experimental Eye Research
Gerardo Ávalos, Diego Salazar, Ana Leticia Rodríguez Araya,
ABSTRACT Many arborescent palms develop a stilt root cone that provides increased mechanical support on steep hillsides, better root aeration under waterlogged conditions, resprouting after mechanical damage, and rapid stem elongation. However, for most species the role of stilt roots is not well understood. We determined how palm size and slope inclination affected the structure of stilt roots in the neotropical palms Iriartea deltoidea and Socratea exorrhiza . We expected palm height to be lower ...
Tópico(s): Legume Nitrogen Fixing Symbiosis
2005 - Wiley | Biotropica
Lúcio H. Freitas-Júnior, Rosaura Hernández‐Rivas, Stuart A. Ralph, Dvorak Montiel-Condado, Omar K. Ruvalcaba-Salazar, Ana Paola Rojas-Meza, Liliana Mâncio-Silva, Ricardo Silvestre, Alisson M. Gontijo, Spencer Shorte, Artur Scherf,
Malaria parasites use antigenic variation to avoid immune clearance and increase the duration of infection in the human host. Variation at the surface of P. falciparum-infected erythrocytes is mediated by the differential control of a family of surface antigens encoded by var genes. Switching of var gene expression occurs in situ, mostly from telomere-associated loci, without detectable DNA alterations, suggesting that it is controlled by chromatin structure. We have identified chromatin modifications ...
Tópico(s): vaccines and immunoinformatics approaches
2005 - Cell Press | Cell
Alberto Triviño, José M. Ramı́rez, Juan J. Salazar, Ana I. Ramı́rez, J. García-Sánchez,
Immunocytochemical localization of glial fibrillary acidic protein (GFAP) has been used to study the distribution of astrocytes and their morphology in sections of the optic nerve (ON) of human eye. Although all ON regions presented GFAP immunoreactivity, immunostained tissue was most common in the posterior prelaminar region (PR) and least common in the laminar region (LR). Two shapes of astrocytes were distinguished: thick and thin bodied astrocytes. Astrocytes with thick cell bodies are located in ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
1996 - Elsevier BV | Vision Research
Antonio J. Salazar, Ana Sofia Silva, Cláudia Silva, Carla M. Borges, Miguel Velhote Correia, Rubim Santos, João Paulo Vilas‐Boas,
Background: An increasingly aging society and consequently rising number of patients with poststroke-related neurological dysfunctions are forcing the rehabilitation field to adapt to ever-growing demands. Although clinical reasoning within rehabilitation is dependent on patient movement performance analysis, current strategies for monitoring rehabilitation progress are based on subjective time-consuming assessment scales, not often applied. Therefore, a need exists for efficient nonsubjective monitoring ...
Tópico(s): Acute Ischemic Stroke Management
2014 - Taylor & Francis | Topics in Stroke Rehabilitation
Paula F. Quiroz Velasquez, Sumayyah K. Abiff, Katrina C. Fins, Quincy B. Conway, Norma C. Salazar, Ana Paula Delgado, Jhanelle K. Dawes, Lauren G. Douma, Aurélien Tartar,
A combination of 454 pyrosequencing and Sanger sequencing was used to sample and characterize the transcriptome of the entomopathogenic oomycete Lagenidium giganteum. More than 50,000 high-throughput reads were annotated through homology searches. Several selected reads served as seeds for the amplification and sequencing of full-length transcripts. Phylogenetic analyses inferred from full-length cellulose synthase alignments revealed that L giganteum is nested within the peronosporalean galaxy ...
Tópico(s): Studies on Chitinases and Chitosanases
2014 - American Society for Microbiology | Applied and Environmental Microbiology
Hugo Salazar, Ana Catarina Lima, Ana Catarina Lopes, Gabriela Botelho, S. Lanceros‐Méndez,
Poly(vinylidene fluoride-trifluoroethylene)/NaY zeolite composite membranes were prepared by solvent casting and evaluated as a suitable drug release platform through the evaluation of loading and release of ibuprofen. The membranes were characterized at the morphological, structural and mechanical levels. The 1H NMR spectra indicate that only the membranes with 16 and 32% of NaY were useful for IBU encapsulation and the drug release was followed by UV–vis spectroscopy. The release profile is independent ...
Tópico(s): Advanced Battery Materials and Technologies
2015 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Produção Nacional
Revisado por pares
Gabriela Lopes dos Santos, Luisa Fernanda García-Salazar, Ana Carolina Lazarin, Thiago Luiz Russo,
Background:The stroke is the leading cause of adult disability in the world. One of the main complaints of individuals post-stroke refers to the loss of function of the upper limb, as evidenced during the performance of activities of daily living. This difficulty may be related to an important component of sensorimotor control, joint position sense, a submodality of proprioception.Objectives:To investigate whether the proprioception of both shoulders of chronic hemiparetic patients is altered during ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2015 - Taylor & Francis | Topics in Stroke Rehabilitation
M. Joan Curcio, Ivan L. Salazar, Ana R. Inácio, Emı́lia P. Duarte, Lorella M.T. Canzoniero, Carlos B. Duarte,
Abstract The glial cell line-derived neurotrophic factor (GDNF) has an important role in neuronal survival through binding to the GFR α 1 (GDNF family receptor alpha-1) receptor and activation of the receptor tyrosine kinase Ret. Transient brain ischemia alters the expression of the GDNF signaling machinery but whether the GDNF receptor proteins are also affected, and the functional consequences, have not been investigated. We found that excitotoxic stimulation of cultured hippocampal neurons leads ...
Tópico(s): RNA regulation and disease
2015 - Springer Nature | Cell Death and Disease
Iván Guerra, Tamara Pérez-Jeldres, Marisa Iborra, Alicia Algaba, David Monfort, Xavier Calvet, María Chaparro, Míriam Mañosa, Esther Hinojosa, Miguel Mínguez, Jone Ortiz de Zárate, Lucía Márquez, Vanessa Prieto, Valle García–Sánchez, Jordi Guardiola, G E Rodríguez, María Dolores Martín‐Arranz, Iván García-Tercero, Beatriz Sicilia, Ángeles Masedo, R Lorente, Montserrat Rivero, Luís Fernández-Salazar, Ana Gutiérrez, Manuel Van Domselaar, Antonio López-Sanromán, Yolanda Ber, Marifé García-Sepulcre, Laura Ramos, Fernando Bermejo, Javier P. Gisbert,
Psoriasis induced by anti-tumor necrosis factor-α (TNF) therapy has been described as a paradoxical side effect.To determine the incidence, clinical characteristics, and management of psoriasis induced by anti-TNF therapy in a large nationwide cohort of inflammatory bowel disease patients.Patients with inflammatory bowel disease were identified from the Spanish prospectively maintained Estudio Nacional en Enfermedad Inflamatoria Intestinal sobre Determinantes genéticos y Ambientales registry of Grupo ...
Tópico(s): Pregnancy and Medication Impact
2016 - Oxford University Press | Inflammatory Bowel Diseases
Rene G. Moran-Salazar, Ana Lorena Sanchez-Lizarraga, Jacobo Rodríguez-Campos, Gustavo Dávila-Vazquez, Erika Nahomy Marino-Marmolejo, Luc Dendooven, Silvia Maribel Contreras-Ramos,
Vinasses are a residual liquid generated after the production of beverages, such as mezcal and tequila, from agave (Agave L.), sugarcane (Saccharum officinarum L.) or sugar beet (Beta vulgaris L.). These effluents have specific characteristics such as an acidic pH (from 3.9 to 5.1), a high chemical oxygen demand (50,000–95,000 mg L−1) and biological oxygen demand content (18,900–78,300 mg L−1), a high total solids content (79,000 and 37,500 mg L−1), high total volatile solids 79,000 and 82,222 mg L−1, ...
Tópico(s): Biofuel production and bioconversion
2016 - Springer International Publishing | SpringerPlus