Lidia E. Chinchilla, Carol M. Olmos, Alberto Villa, Anna Carlsson, Laura Prati, Xiaowei Chen, Ginesa Blanco, José J. Calvino, Ana B. Hungría,
In the present work, a series of supported gold–ruthenium bimetallic catalysts of varying Au:Ru molar ratios were prepared onto ceria–zirconium mixed oxide (Ce0.62Zr0.38O2) using sequentially deposition-precipitation and impregnation techniques to add gold and ruthenium, respectively. A combination of X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) analyses and different transmission electron microscopy techniques as high-resolution transmission electron microscopy (HRTEM), high-angle ...
Tópico(s): Mesoporous Materials and Catalysis
2015 - Elsevier BV | Catalysis Today
Teresa Hungrı́a, Ana B. Hungría, A. Castro,
A novel mechanochemical activation route has been applied in order to obtain the n=1–4 and ∞ members of the Sr2[Srn−1TinO3n+1] Ruddlesden–Popper series. The evolution of the (n+1)SrO:nTiO2 powder mixtures during mechanical treatment was followed by X-ray powder diffraction in all cases. Except for the 2SrO:TiO2 composition, SrTiO3 was always mechanosynthesized. High-energy milling of 2SrO:TiO2 sample resulted in the formation of nanosized Sr2TiO4, which is the only K2NiF4-type oxide prepared by mechanical ...
Tópico(s): Advanced Condensed Matter Physics
2004 - Elsevier BV | Journal of Solid State Chemistry
Produção Nacional
Revisado por pares
Emerith Mayra Hungria, Regiane Morillas Oliveira, Ana Lúcia Osório Maroclo de Souza, Maurício Barcelos Costa, Vânia Niéto Brito de Souza, Eliane Aparecida Silva, Fátima Regina Vilani Moreno, Maria Esther Salles Nogueira, Maria Renata Sales Nogueira Costa, Sônia Maria Usó Ruiz Silva, Samira Bührer-Sékula, Steven G. Reed, Malcolm S. Duthie, Mariane Martins de Araújo Stefani,
New Mycobacterium leprae protein antigens can contribute to improved serologic tests for leprosy diagnosis/classification and multidrug therapy (MDT) monitoring. This study describes seroreactivity to M. leprae proteins among participants from three highly endemic leprosy areas in Brazil: central-western Goiânia/Goiás (GO) (n = 225), Rondonópolis/Mato Grosso (MT) (n = 764) and northern Prata Village/Pará (PA) (n = 93). ELISA was performed to detect IgG to proteins (92f, 46f, leprosy IDRI diagnostic-1, ML0405, ...
Tópico(s): Tuberculosis Research and Epidemiology
2012 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
María J. Climent, Avelino Corma, Juan Carlos Hernández‐Garrido, Ana B. Hungría, Sara Iborra, Sergio Martínez‐Silvestre,
An efficient and selective one-pot two-step method, for the synthesis of quinoxalines by oxidative coupling of vicinal diols with 1,2-phenylenediamine derivatives, has been developed by using gold nanoparticles supported on nanoparticulated ceria (Au/CeO2) or hydrotalcite (Au/HT) as catalysts and air as oxidant, in the absence of any homogeneous base. Reaction kinetics shows that the reaction controlling step is the oxidation of the diol to α-hydroxycarbonyl compound. Furthermore, a one-pot three- ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2012 - Elsevier BV | Journal of Catalysis
Produção Nacional
Revisado por pares
Danielle de Freitas Mizoguti, Emerith Mayra Hungria, Aline Araújo Freitas, Regiane Morillas Oliveira, Ludimila Paula Vaz Cardoso, Maurício Barcelos Costa, Ana Lucia M. Sousa, Malcolm S. Duthie, Mariane Martins Araújo Stefani,
Leprosy inflammatory episodes [type 1 (T1R) and type 2 (T2R) reactions] represent the major cause of irreversible nerve damage. Leprosy serology is known to be influenced by the patient's bacterial index (BI) with higher positivity in multibacillary patients (MB) and specific multidrug therapy (MDT) reduces antibody production. This study evaluated by ELISA antibody responses to leprosy Infectious Disease Research Institute diagnostic-1 (LID-1) fusion protein and phenolic glycolipid I (PGL-I) in 100 paired ...
Tópico(s): Ocular Diseases and Behçet’s Syndrome
2015 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Ana Luiza Miranda Silva Dias, Fabiana Higashi, Ana Lucia Peres, Pricilla Cury, Edvan de Queiroz Crusoé, Vânia Hungria,
The estimated involvement of the central nervous system in patients with multiple myeloma is rare at about 1%. The infiltration can be identified at the time multiple myeloma is diagnosed or during its progression. However, it is more common in refractory disease or during relapse.
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2017 - Elsevier BV | Hematology Transfusion and Cell Therapy
Produção Nacional
Revisado por pares
Maurício Barcelos Costa, Emerith Mayra Hungria, Aline Araújo Freitas, Ana Lúcia Osório Maroccolo de Sousa, Juliano Jampietro, Fernando Augusto Soares, Mariane M. A. Stefani,
Leprosy is a complex chronic, infectious dermato-neurological disease that affects the skin and peripheral nerves especially during immuno-inflammatory episodes known as type 1/T1R and type 2/T2R reactions. This study investigated the in situ expression of CD25+Foxp3+ Treg cells and TGF-β1, IFN-γ, IL-17 in leprosy T1R and T2R. Tregs were evaluated in 114 skin biopsies from 74 leprosy patients: 56 T1R (28-paired reaction-free/reactional biopsies, 28 unpaired T1R), 18 T2R (12 paired reaction-free/reactional ...
Tópico(s): Mycobacterium research and diagnosis
2018 - Public Library of Science | PLoS ONE
Siris Laursen, Diego Combita, Ana B. Hungría, Mercedes Boronat, Avelino Corma,
Catalyst design: First principles calculations predict that phosgene can be substituted by dimethyl carbonate (DMC) in the carbamoylation of aromatic amines when using a CeO2 catalyst preferentially exposing the low energy {111} facet. Experimental results confirm the theoretical predictions, and CeO2 nano-octahedra terminated by low energy {111} facets show high activity and selectivity toward the desired dicarbamoylated product.
Tópico(s): Asymmetric Hydrogenation and Catalysis
2012 - Wiley | Angewandte Chemie International Edition
A. Martı́nez-Arias, Marcos Fernández-Garcı́a, Ana B. Hungría, J.C. Conesa, G. Munuera,
Two Zr−Ce (1:1 molar ratio) mixed oxide specimens, made by the same microemulsion method from different cerium precursor salts (samples ZC1 and ZC2), have been studied by a combination of physicochemical techniques. After calcination at 773 K (high surface area materials HS: SBET = 96 ± 1 m2 g-1) both samples present similar characteristics in XRD, Raman and TEM (pseudocubic phase t‘ ‘), and XPS/Ar+-etching experiments. This latter evidence for those materials gives a similar moderate surface enrichment in ...
Tópico(s): Radioactive element chemistry and processing
2003 - American Chemical Society | The Journal of Physical Chemistry B
Produção Nacional
Revisado por pares
R M Oliveira, Emerith Mayra Hungria, A. de Araújo Freitas, Ana Lúcia Osório Maroccolo de Sousa, Maurício Barcelos Costa, Steven G. Reed, Malcolm S. Duthie, Mariane M. A. Stefani,
Tópico(s): Infectious Diseases and Tuberculosis
2014 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Produção Nacional
Revisado por pares
Aline Araújo Freitas, Regiane Morillas Oliveira, Emerith Mayra Hungria, Ludimila Paula Vaz Cardoso, Ana Lúcia Osório Maroccolo de Sousa, Maurício Barcelos Costa, Steven G. Reed, Malcolm S. Duthie, Mariane M. A. Stefani,
This study evaluated the impact of leprosy multidrug therapy (MDT) on cell-mediated immunity (CMI) and antibody responses at diagnosis in untreated paucibacillary (PB) (n=15) and multibacillary (MB) patients (n=15) using a panel of Mycobacterium leprae recombinant antigens (rMLs) (CMI: 46f, ML0276, ML2055, leprosy IDRI diagnostic 1 [LID-1], and ML2629, as negative control; serology: LID-1, 46f, 92f, and 33f, as negative control, and phenolic glycolipid I [PGL-I]) and at 2 time points after MDT (PB: 8-20months; ...
Tópico(s): Infectious Diseases and Tuberculosis
2015 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Begoña Puértolas, Álvaro Mayoral, Raúl Arenal, Benjamín Solsona, Alaina Moragues, Sonia Murcia‐Mascarós, Pedro Amorós, Ana B. Hungría, Stuart H. Taylor, Tomás García,
Metal nanoparticles with precisely controlled size are highly attractive for heterogeneous catalysis. However, their poor thermal stability remains a major concern in their application at realistic operating conditions. This paper demonstrates the possibility of synthesizing gold nanoparticles with exceptional thermal stability. This has been achieved by using a simple conventional deposition–precipitation technique. The material employed as catalyst consists of gold supported on a TiO2-impregnated ...
Tópico(s): Catalysis and Hydrodesulfurization Studies
2015 - American Chemical Society | ACS Catalysis
Diego Ruiz, Blanca del Rosal, Marı́a Acebrón, Cristina Palencia, Chen Sun, Juan Cabanillas‐González, Miguel López‐Haro, Ana B. Hungría, Daniel Jaque, Beatriz H. Juárez,
Temperature sensing in biological media (cells, tissues, and living organisms) has become essential in the development of the last generation of diagnostics and therapeutic strategies. Thermometry can be used for early detection of different diseases, such as cancer, stroke, or inflammation processes, one of whose incipient symptoms is the appearance of localized temperature singularities. Luminescence nanothermometry, as a tool to accurately provide temperature sensing in biological media, requires ...
Tópico(s): Photoacoustic and Ultrasonic Imaging
2016 - Wiley | Advanced Functional Materials
Produção Nacional
Revisado por pares
Edvan de Queiroz Crusoé, Ana Maria Marinho da Silva, Jozina Marian de Andrade Agareno, Maria de Lourdes Chauffaille, Carmem Bonfim, Vânia Tietsche Moraes Hungria,
Rare cases of multiple myeloma (MM) were diagnosed in patients younger than 20 years of age in the literature. In these cases, its clinical presentation and laboratory test parameters were poorly characterized.
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2014 - Elsevier BV | Clinical Lymphoma Myeloma & Leukemia
Karen J. Uffalussy, Burjor Captain, Richard D. Adams, Ana B. Hungría, John R. Monnier, Michael D. Amiridis,
Magnesia-supported trimetallic Pt–Ru–Sn catalysts prepared through a cluster and a conventional synthetic route have been investigated in terms of their structural properties and their catalytic activity for the hydrogenation of citral. FTIR results indicate that the majority of the stabilizing ligands remain attached to the PtRu5(μ-SnPh2)(C)(CO)15 cluster used following impregnation onto the MgO support. Under H2 reduction conditions, partial and full ligand removal are observed at 473 and 573 ...
Tópico(s): Nanomaterials for catalytic reactions
2011 - American Chemical Society | ACS Catalysis
Produção Nacional
Revisado por pares
Ana Carolina Hungria Xavier, Carla Regina Veiga Barcelos, Jaqueline Peixoto Lopes, Priscila Gandarela Chamarelli, Sarah de Souza Ribeiro, Luciene da Silva Lacerda, Marisa Palácios,
Este artigo objetiva analisar a magnitude e algumas características do fenômeno do assédio moral no trabalho no setor saúde do Rio de Janeiro. Foram analisados dados de pesquisa desenvolvida em 2001 como parte do programa "Violência no Trabalho no Setor Saúde", resultantes de um inquérito anônimo. Para constituir o banco para análise, foram selecionados todos os casos (1.569) e as variáveis relacionadas ao assédio moral. O grupo profissional que teve maior proporção de vítimas de assédio moral foi ...
Tópico(s): Intimate Partner and Family Violence
2008 - Fundacentro | Revista Brasileira de Saúde Ocupacional
Kenji Kaneko, Koji Inoke, Bert Freitag, Ana B. Hungría, Paul A. Midgley, Thomas W. Hansen, Jing Zhang, Satoshi Ohara, Tadafumi Adschiri,
Colloidal cerium oxide (CeO2) nanocrystals prepared by hydrothermal synthesis were characterized by high-resolution transmission electron microscopy (HRTEM) and three-dimensional electron tomography (3D-ET). HRTEM images of individual CeO2 nanocrystals were then simulated by Blochwave and multislice simulations to determine the atomic arrangement and terminating atoms. The edge length distributions were between 5.0 and 8.0 nm with an average edge length of 6.7 nm. The HRTEM images showed that the CeO2 ...
Tópico(s): Electronic and Structural Properties of Oxides
2007 - American Chemical Society | Nano Letters
Carol M. Olmos, Lidia E. Chinchilla, Alberto Villa, Juan J. Delgado, Huiyan Pan, Ana B. Hungría, Ginesa Blanco, José J. Calvino, Laura Prati, Xiaowei Chen,
Monometallic Au, Pd and bimetallic Au-Pd catalysts supported on a Ce0.62Zr0.38O2 mixed oxide have been synthesized by the sol-immobilization method. An in-depth Scanning-Transmission Electron Microscopy (STEM) study has been performed to reveal the structural and chemical nature of the metal nanoparticle system present in these catalysts. Attention has been paid both to the evolution of the particle size distribution and the degree of Au-Pd interaction as a function of the treatment used to activate ...
Tópico(s): Oxidative Organic Chemistry Reactions
2016 - Elsevier BV | Applied Catalysis A General
Carol M. Olmos, Lidia E. Chinchilla, Andrea M. Cappella, Alberto Villa, Juan J. Delgado, Ana B. Hungría, Ginesa Blanco, José J. Calvino, Laura Prati, Xiaowei Chen,
The selective oxidation of veratryl alcohol (VA), a model compound of lignin, with oxygen molecules to produce veratraldehyde (VAld) was studied over monometallic Au, Pd, and bimetallic Au:Pd nanoparticles supported on a Ce0.62Zr0.38O₂ mixed oxide for the first time. These bimetallic Au-Pd catalysts with Au:Pd molar ratios from 0.4 to 4.3 were synthesized by the sol-immobilization method. Furthermore, all the catalysts were characterized by inductively coupled plasma-atomic emission spectroscopy (ICP- ...
Tópico(s): Catalysis and Oxidation Reactions
2018 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Carol M. Olmos, Lidia E. Chinchilla, Alberto Villa, Juan J. Delgado, Ana B. Hungría, Ginesa Blanco, Laura Prati, José J. Calvino, Xiaowei Chen,
A bimetallic Au-Pd catalyst supported on ceriazirconia with Au:Pd molar ratio 0.8 has been synthesized using a simultaneous deposition-precipitation method and oxidized at 250, 450, and 700 $^\circ$C in order to modify its particle size, nanostructure, and composition. Combined Xray energy dispersive spectroscopy and Xray photoelectron spectroscopy analysis clearly evidence that the bimetallic Au-Pd catalyst oxidized at 250 $^\circ$C is made up of a mixture of monometallic Au and Pd and bimetallic Au- ...
Tópico(s): Nanomaterials for catalytic reactions
2019 - Elsevier BV | Journal of Catalysis
Produção Nacional
Revisado por pares
Maurício Barcelos Costa, Kallyne Kioko Oliveira Mimura, Aline Araújo Freitas, Emerith Mayra Hungria, Ana Lúcia Osório Maroccolo de Sousa, Sônia Maria Oliani, Mariane M. A. Stefani,
Mast cells (MCs) have important immunoregulatory roles in skin inflammation. Annexin A1 (ANXA1) is an endogenous anti-inflammatory protein that can be expressed by mast cells, neutrophils, eosinophils, monocytes, epithelial and T cells. This study investigated MCs heterogeneity and ANXA1 expression in human dermatoses with special emphasis in leprosy. Sixty one skin biopsies from 2 groups were investigated: 40 newly diagnosed untreated leprosy patients (18 reaction-free, 11 type 1 reaction/T1R, 11 ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2018 - Elsevier BV | Microbial Pathogenesis
Produção Nacional
Revisado por pares
Vânia Hungria, Edvan Crusoé, Ângelo Maiolino, Rosane Bittencourt, Dorotea Fantl, J.F.R. Maciel, Roberto Magalhães, Manuella S.S. Almeida, Priscilla Cury, F Hisgashi, Ana Lucia Peres, Carlos Chiattone,
Tópico(s): Protein Degradation and Inhibitors
2015 - Springer Science+Business Media | Annals of Hematology
Laura Barrio, Michael Estrella, Gong Zhou, Wen Wen, Jonathan C. Hanson, Ana B. Hungría, Aitor Hornés, Marcos Fernández-Garcı́a, A. Martı́nez-Arias, José A. Rodríguez,
An inverse powder system composed of CeO2 nanoparticles dispersed over a CuO−Cu matrix is proposed as a novel catalyst for the water−gas shift reaction. This inverse CeO2/CuO−Cu catalyst exhibits a higher activity than standard Cu/CeO2 catalysts. In situ synchrotron characterization techniques were employed to follow the structural changes of CeO2/CuO−Cu under reaction conditions. Time-resolved X-ray diffraction experiments showed the transformation of CuO to metallic Cu via a Cu2O intermediate. ...
Tópico(s): Electrocatalysts for Energy Conversion
2010 - American Chemical Society | The Journal of Physical Chemistry C
Produção Nacional
Edvan de Queiroz Crusoé, Fabiana Higashi, Maria Paula Nalesso Camargo Padilha, Eliana Miranda, Adriana Alvares Quero, Manuella de Souza Sampaio Almeida, Ana Lucia Peres, Priscilla Cury, Carlos Chiattone, José Carlos Barros, Vânia Hungria,
Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma.The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and dexamethasone, and whether cyclophosphamide, thalidomide, and dexamethasone were associated with better results than thalidomide and dexamethasone.The records of 152 patients ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2014 - Elsevier BV | Revista Brasileira de Hematologia e Hemoterapia
José A. Pérez‐Omil, Juan J. Delgado, Widad Ouahbi, Ana B. Hungría, Nigel D. Browning, M.A. Cauqui, J.M. Rodrı́guez-Izquierdo, José J. Calvino,
A series of Ce/Mn oxides has been characterized using a variety of complementary transmission electron microscopy techniques to obtain nanometer scale information on the structure, chemical composition, and oxidation states of the different phases present in this extremely complex system. The phases have been identified to be α-Mn2O3, β-MnO2, mixed-valence manganese oxides (Mn3O4 and Mn5O8), and Ce−Mn mixed oxides in different proportions depending on the Ce/Mn atomic ratio. A correlation between ...
Tópico(s): Nanomaterials for catalytic reactions
2010 - American Chemical Society | The Journal of Physical Chemistry C
Juan Carlos Hernández‐Garrido, Ana B. Hungría, José A. Pérez‐Omil, Susana Trasobares, Serafı́n Bernal, Paul A. Midgley, Ali Alavi, José J. Calvino,
High-resolution electron microscopy, high-angle annular dark field images, electron tomography data, and density functional theory calculations are presented that show the occurrence of significant structural and surface modifications in a nanocrystalline sample of cerium−zirconium mixed oxide upon high-temperature reduction with hydrogen followed by mild oxidation. Our findings may lend further support to a recently proposed model in accordance with which the enhanced reducibility exhibited by ...
Tópico(s): Copper-based nanomaterials and applications
2007 - American Chemical Society | The Journal of Physical Chemistry C
Produção Nacional
Revisado por pares
Aline Araújo Freitas, Emerith Mayra Hungria, Maurício Barcelos Costa, Ana Lúcia Osório Maroccolo de Sousa, Mirian Lane Oliveira Rodrigues Castilho, Heitor S. Gonçalves, Maria Araci de Andrade Pontes, Malcolm S. Duthie, Mariane M. A. Stefani,
Mycobacterium leprae-specific serological and cell-mediated-immunity/CMI test were evaluated for the differential diagnosis of multibacillary/MB, and paucibacillary/PB leprosy from other dermatoses. Whole-blood assay/WBA/IFNγ stimulated with LID-1 antigen and ELISA tests for IgG to LID-1 and IgM to PGL-I were performed. WBA/LID-1/IFNγ production was observed in 72% PB, 11% MB leprosy, 38% dermatoses, 40% healthy endemic controls/EC. The receiver operating curve/ROC for WBA/LID-1 in PB versus other ...
Tópico(s): Infectious Diseases and Tuberculosis
2016 - Elsevier BV | Diagnostic Microbiology and Infectious Disease
Eloy del Río, Ana B. Hungría, Miguel Tinoco, Ramón Manzorro, M.A. Cauqui, José J. Calvino, José A. Pérez‐Omil,
The 1.5 wt% Au/TiO2 World Gold Council catalyst (WGC) was modified by depositing on its surface a 5.4 wt% CeO2 loading by incipient wetness impregnation. Calcination at 673 K of the resulting, surface-modified, catalyst yielded a material in which the system of gold particles was not significantly modified with respect to that of the starting 1.5% Au/TiO2 WGC catalyst, neither in terms of its size distribution or metallic dispersion. The latter parameter remained, as in the catalyst prior to CeO2 ...
Tópico(s): Nanomaterials for catalytic reactions
2016 - Elsevier BV | Applied Catalysis B Environment and Energy
Produção Nacional
Revisado por pares
Priscilla Cury, Fabiana Higashi, Flávia Fernandes Silva Zacchi, Renata Bacic Palhares, Adriana Alvares Quero, Ana Luiza Miranda Silva Dias, Edvan de Queiroz Crusoé, Vânia Hungria,
Bone marrow angiogenesis is increased in multiple myeloma (MM) patients, prompting the rationale for using antiangiogenic drugs in the treatment of these patients. To assess angiogenesis in patients with MM at diagnosis and following treatment with an antiangiogenic drug. Twenty-three patients with newly diagnosed MM were treated with thalidomide-based regimens. Bone marrow evaluation was made before and following treatment and included angiogenesis assessment, which was quantified through microvessel ...
Tópico(s): Myeloproliferative Neoplasms: Diagnosis and Treatment
2019 - Elsevier BV | Hematology Transfusion and Cell Therapy
Miguel Tinoco, Susana Fernández‐Garcia, Miguel López‐Haro, Ana B. Hungría, Xiaowei Chen, Ginesa Blanco, José A. Pérez‐Omil, Sebastián E. Collins, Hanako Okuno, José J. Calvino,
A partial transformation of the {100} surfaces of ceria nanocubes into a set of nanometer-heighted, {111}-bounded, peaks was achieved by an oxidation treatment at 600 °C. This particular type of surface nanostructuration allows the preparation of CeO2 nanoparticles in which {111} nanofacets contribute significantly to their surface crystallography. This transformation of the surface structure plays a key influence on the behavior of ceria as a support of gold catalysts. Thus, the appearance of well- ...
Tópico(s): Nanomaterials for catalytic reactions
2015 - American Chemical Society | ACS Catalysis