... 2012Joshi C.P. Panda D. Martell D.J. Andoy N.M. Chen T.Y. Gaballa A. Helmann ... 2012Joshi C.P. Panda D. Martell D.J. Andoy N.M. Chen T.Y. Gaballa A. Helmann ...
Tópico(s): Bacterial Genetics and Biotechnology
2013 - Cell Press | Cell
Halyna Lugova, Jo Ann Andoy-Galvan, Sapna Shridhar Patil, Yin How Wong, Gul Baloch, Adlina Suleiman, Rusli Bin Nordin, Karuthan Chinna,
Tópico(s): Psychological Well-being and Life Satisfaction
2021 - Springer Science+Business Media | Community Mental Health Journal
Celia Ferrag, Shaopei Li, Keuna Jeon, Nesha May Andoy, Ruby May A. Sullan, Svetlana Mikhaylichenko, Kağan Kerman,
The incorporation of nanoparticles into a hydrogel matrix enables the development of innovative smart materials with enhanced biophysical properties. In this proof-of-concept study, we encapsulated different shapes (spherical, triangular and rod) of silver nanoparticles (AgNPs) within a hydrogel matrix of polyacrylamide (PAA) and N-methylenebisacrylamide (MBA) (PAA-MBA) to investigate whether these hydrogels exhibited shape-dependent antimicrobial and mechanical properties. We examined the mechanism ...
Tópico(s): Nanoparticles: synthesis and applications
2020 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Natashya Falcone, Tsuimy Shao, Nesha May Andoy, Roomina Rashid, Ruby May A. Sullan, Xiaoyi Sun, Heinz‐Bernhard Kraatz,
A systematic study showcasing a library of multi-component gels using the novel gelator C14-FF and various biocomponents for the development of tuneable matrices.
Tópico(s): Glycosylation and Glycoproteins Research
2020 - Royal Society of Chemistry | Biomaterials Science
Nesha May Andoy, Keuna Jeon, Christian Titus Kreis, Ruby May A. Sullan,
Abstract The rising threat of antimicrobial resistance is a crisis of a global scale. If not addressed, it can lead to health care system problems worldwide. This warrants alternative therapeutic approaches whose mechanism of action starkly differs from conventional antibiotic‐based therapies. Here, a multifunctional and stimuli‐responsive (NIR laser‐activated) antimicrobial platform is engineered by combining the intrinsic photothermal capability and excellent biocompatibility of polydopamine nanoparticles ( ...
Tópico(s): Antimicrobial agents and applications
2020 - Wiley | Advanced Functional Materials
Ningmu Zou, Xiaochun Zhou, Guanqun Chen, Nesha May Andoy, Won Jung, Guokun Liu, Peng Chen,
Tópico(s): Electrochemical Analysis and Applications
2018 - Nature Portfolio | Nature Chemistry
Nesha May Andoy, Marcin S. Filipiak, Daniel Vetter, Óscar Gutiérrez‐Sanz, Alexey Tarasov,
Abstract Purely electronic diagnostic devices that are sensitive to biomolecules' intrinsic charge present a very attractive platform for point‐of‐care (PoC) applications, since they can operate under label‐free conditions. In this report, a graphene‐based electrolyte‐gated field‐effect transistor is developed as an immunosensor capable of sensitive analyte detection, even in the complex environment of physiological samples. The coimmobilization of an antibody fragment (F(ab′) 2 ) and polyethylene glycol ...
Tópico(s): Graphene research and applications
2018 - Wiley | Advanced Materials Technologies
Óscar Gutiérrez‐Sanz, Nesha May Andoy, Marcin S. Filipiak, Natalie Haustein, Alexey Tarasov,
Transistor-based biosensors fulfill many requirements posed upon transducers for future point-of-care diagnostic devices such as scalable fabrication and label-free and real-time quantification of chemical and biological species with high sensitivity. However, the short Debye screening length in physiological samples (<1 nm) has been a major drawback so far, preventing direct measurements in serum. In this work, we demonstrate how tailoring the sensing surface with short specific biological receptors ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2017 - American Chemical Society | ACS Sensors
Marcin S. Filipiak, Marcel Rother, Nesha May Andoy, Arne C. Knudsen, Stefan Grimm, Christopher Bachran, Lee Kim Swee, Jana Zaumseil, Alexey Tarasov,
Nanomaterial-based field-effect transistors (FETs) have been proposed for real-time, label-free detection of various biological species. However, two major challenges have limited their use in physiological samples: screening of the analyte charge by electrolyte ions (Debye screening) and non-specific adsorption. Here, these challenges are overcome by combining highly stable FETs based on single-walled semiconducting carbon nanotube (SWCNTs) networks with a novel surface functionalization comprising: ...
Tópico(s): Mechanical and Optical Resonators
2017 - Elsevier BV | Sensors and Actuators B Chemical
Peng Chen, Xiaochun Zhou, Nesha May Andoy, Kyu‐Sung Han, Eric Choudhary, Ningmu Zou, Guanqun Chen, Hao Shen,
This review discusses the latest advances in using single-molecule microscopy of fluorogenic reactions to examine and understand the spatiotemporal catalytic behaviors of single metal nanoparticles of various shapes including pseudospheres, nanorods, and nanoplates. Real-time single-turnover kinetics reveal size-, catalysis-, and metal-dependent temporal activity fluctuations of single pseudospherical nanoparticles (<20 nm in diameter). These temporal catalytic dynamics can be related to nanoparticles' ...
Tópico(s): Advanced Fluorescence Microscopy Techniques
2013 - Royal Society of Chemistry | Chemical Society Reviews
Peng Chen, Aaron M. Keller, Chandra P. Joshi, Danya J. Martell, Nesha May Andoy, Jaime J. Benítez, Tai‐Yen Chen, Ace George Santiago, Feng Yang,
Understanding how cells regulate and transport metal ions is an important goal in the field of bioinorganic chemistry, a frontier research area that resides at the interface of chemistry and biology. This Current Topic reviews recent advances from the authors' group in using single-molecule fluorescence imaging techniques to identify the mechanisms of metal homeostatic proteins, including metalloregulators and metallochaperones. It emphasizes the novel mechanistic insights into how dynamic protein– ...
Tópico(s): Spectroscopy and Quantum Chemical Studies
2013 - American Chemical Society | Biochemistry
Nesha May Andoy, Xiaochun Zhou, Eric Choudhary, Hao Shen, Guokun Liu, Peng Chen,
Shape-controlled metal nanocrystals are a new generation of nanoscale catalysts. Depending on their shapes, these nanocrystals exhibit various surface facets, and the assignments of their surface facets have routinely been used to rationalize or predict their catalytic activity in a variety of chemical transformations. Recently we discovered that for 1-dimensional (1D) nanocrystals (Au nanorods), the catalytic activity is not constant along the same side facets of single nanorods but rather differs ...
Tópico(s): Quantum Dots Synthesis And Properties
2013 - American Chemical Society | Journal of the American Chemical Society
Xiaochun Zhou, Eric Choudhary, Nesha May Andoy, Ningmu Zou, Peng Chen,
High-throughput and quantitative screening of catalyst activity is crucial for guiding the work cycles of catalyst improvements and optimizations. For nanoparticle catalysts, their inherent heterogeneity makes it desirable to screen them at the single-particle level. Here, we report a single-molecule fluorescence microscopy approach that can screen the activity quantitatively of a large number of catalyst particles in parallel at the single-particle level and with subdiffraction spatial resolution. ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2013 - American Chemical Society | ACS Catalysis
Xiaochun Zhou, Nesha May Andoy, Guokun Liu, Eric Choudhary, Kyu‐Sung Han, Hao Shen, Peng Chen,
Tópico(s): Near-Field Optical Microscopy
2012 - Nature Portfolio | Nature Nanotechnology
Chandra P. Joshi, Debashis Panda, Danya J. Martell, Nesha May Andoy, Tai‐Yen Chen, Ahmed Gaballa, John D. Helmann, Peng Chen,
Metalloregulators regulate transcription in response to metal ions. Many studies have provided insights into how transcription is activated upon metal binding by MerR-family metalloregulators. In contrast, how transcription is turned off after activation is unclear. Turning off transcription promptly is important, however, as the cells would not want to continue expressing metal resistance genes and thus waste energy after metal stress is relieved. Using single-molecule FRET measurements we studied ...
Tópico(s): Corrosion Behavior and Inhibition
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Peng Chen, Xiaochun Zhou, Hao Shen, Nesha May Andoy, Eric Choudhary, Kyu‐Sung Han, Guokun Liu, Weilin Meng,
This tutorial review covers recent developments in using single-molecule fluorescence microscopy to study nanoscale catalysis. The single-molecule approach enables following catalytic and electrocatalytic reactions on nanocatalysts, including metal nanoparticles and carbon nanotubes, at single-reaction temporal resolution and nanometer spatial precision. Real-time, in situ, multiplexed measurements are readily achievable under ambient solution conditions. These studies provide unprecedented insights ...
Tópico(s): Quantum Dots Synthesis And Properties
2010 - Royal Society of Chemistry | Chemical Society Reviews
Nesha May Andoy, Susanta K. Sarkar, Qi Wang, Debashis Panda, Jaime J. Benítez, Aleksandr Kalininskiy, Peng Chen,
To maintain normal metal metabolism, bacteria use metal-sensing metalloregulators to control transcription of metal resistance genes. Depending on their metal-binding states, the MerR-family metalloregulators change their interactions with DNA to suppress or activate transcription. To understand their functions fundamentally, we study how CueR, a Cu(1+)-responsive MerR-family metalloregulator, interacts with DNA, using an engineered DNA Holliday junction (HJ) as a protein-DNA interaction reporter ...
Tópico(s): Electrochemical Analysis and Applications
2009 - Elsevier BV | Biophysical Journal
Susanta K. Sarkar, Nesha May Andoy, Jaime J. Benítez, Peng R. Chen, Jason S. Kong, Chuan He, Peng Chen,
Protein−DNA interactions are essential for gene maintenance, replication, and expression. Characterizing how proteins interact with and change the structure of DNA is crucial in elucidating the mechanisms of protein function. Here, we present a novel and generalizable method of using engineered DNA Holliday junctions (HJs) that contain specific protein-recognition sequences to report protein−DNA interactions in single-molecule FRET measurements, utilizing the intrinsic structural dynamics of HJs. ...
Tópico(s): Nanocluster Synthesis and Applications
2007 - American Chemical Society | Journal of the American Chemical Society
... 14C datings of three sections at Ramså on Andøy in Vesterålen indicate an age of c. 6000 ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
1986 - Taylor & Francis | Norsk Geografisk Tidsskrift - Norwegian Journal of Geography
Natashya Falcone, Nesha May Andoy, Ruby May A. Sullan, Heinz‐Bernhard Kraatz,
Smart antibacterial systems, delivering antimicrobials in a highly controlled manner, are one strategy toward fighting the rise of antibiotic-resistant pathogens. Here, we engineer a laser-responsive antimicrobial nanocomposite hydrogel combining a peptide amphiphile and a photothermally active polydopamine nanoparticle (PDNP) to entrap the hydrophobic rifampicin within the hydrophilic hydrogel matrix. We show that the ability of the gelator to interact and retain rifampicin within the gel induced ...
Tópico(s): Nanoplatforms for cancer theranostics
2021 - American Chemical Society | ACS Applied Bio Materials
Jo Ann Andoy-Galvan, Halyna Lugova, Sapna Shridhar Patil, Yin How Wong, Gul Muhammad Baloch, Adlina Suleiman, Rusli Bin Nordin, Karuthan Chinna,
Background : Recent studies have shown that higher income is associated with a higher risk for subsequent obesity in low- and middle-income countries, while in high-income countries there is a reversal of the association – higher-income individuals have a lower risk of obesity. The concept of being able to afford to overeat is no longer a predictor of obesity in developed countries. In Malaysia, a trend has been observed that the prevalence of obesity increases with an increase in income among the low-income ( ...
Tópico(s): Global Public Health Policies and Epidemiology
2020 - Faculty of 1000 | F1000Research
Keuna Jeon, Nesha May Andoy, Christian W. Schmitt, Yilei Xue, Leonie Barner, Ruby May A. Sullan,
Polyserotonin-based nanoparticles are a new class of bioinspired nanomaterial with recently demonstrated therapeutic potential for future clinical applications. It is therefore important to establish a robust and rapid method of synthesizing polyserotonin nanoparticles (PSeNP) in the size range ideal for in vivo utilization. Since the formation of PSeNP is base-catalyzed, here we report the influence of solution pH, in the presence of different base systems, on the kinetics of PSeNP formation and ...
Tópico(s): Polymer Surface Interaction Studies
2020 - Royal Society of Chemistry | Journal of Materials Chemistry B
Nesha May Andoy, Marcin S. Filipiak, Daniel Vetter, Óscar Gutiérrez‐Sanz, Alexey Tarasov,
... high charge sensitivity. In article number 1800186, Nesha Andoy, Alexey Tarasov, and co-workers demonstrate label-free ...
Tópico(s): Graphene and Nanomaterials Applications
2018 - Wiley | Advanced Materials Technologies
Peng Chen, Nesha May Andoy, Jaime J. Benítez, Aaron M. Keller, Debashis Panda, Feng Gao,
Covering: up to 2009
Tópico(s): Heavy Metal Exposure and Toxicity
2010 - Royal Society of Chemistry | Natural Product Reports
In recent years, single-molecule methods have enabled many innovative studies in the life sciences, which generated unprecedented insights into the workings of many macromolecular machineries. Single-molecule studies of bioinorganic systems have been limited, however, even though bioinorganic chemistry represents one of the frontiers in the life sciences. With the hope to stimulate more interest in applying existing and developing new single-molecule methods to address compelling bioinorganic problems, ...
Tópico(s): Metal-Catalyzed Oxygenation Mechanisms
2007 - Elsevier BV | Inorganica Chimica Acta
... dr. G. Holmsen dynesandfelter pa Lista, Sunnmore og Andoy, og »flere steder i Finnnmark«. Selv har jeg ...
Tópico(s): Botany and Plant Ecology Studies
1935 - Taylor & Francis | Norsk Geografisk Tidsskrift - Norwegian Journal of Geography
... deeper, respectively, than the extrapolated Late Weichselian North Andøy Shoreline (NAS). These platforms therefore seem to be ...
Tópico(s): Geological formations and processes
2000 - Norwegian Geological Society | Norsk Geologisk Tidsskrift
Nesha May Andoy, Meera Patel, Ching Lam Jane Lui, Ruby May A. Sullan,
Interactions between a widely used polycationic polymer, polyethyleneimine (PEI), and a Gram-negative bacteria, E. coli, are investigated using atomic force microscopy (AFM) quantitative imaging. The effect of PEI, a known membrane permeabilizer, is characterized by probing both the structure and elasticity of the bacterial cell envelope. At low concentrations, PEI induced nanoscale membrane perturbations all over the bacterial surface. Despite these structural changes, no change in cellular mechanics ( ...
Tópico(s): Antimicrobial agents and applications
2021 - Multidisciplinary Digital Publishing Institute | Microorganisms
Obesity is a growing public health concern. Lifestyle modifications should be aggressively promoted in communities, with health care professionals expected to be role models of healthy living. A cross-sectional study using propor-tionate stratified sampling of medical students (n = 179) attending a university in Malaysia revealed prevalence rate of overweight and obesity was 22% and 11%, respectively, based on cut-off points for the Asian population. These values are significantly lower compared to ...
Tópico(s): Health and Well-being Studies
2019 - Central Coordinating Board for Tropical Medicine | Southeast Asian Journal of Tropical Medicine and Public Health
Nowadays, urbanization and smaller households are influencing Filipino consumers in procuring convenience food products. As a convenience food and a potential staple food, saltine crackers were made in this study by combining Job's tear (adlay) flour ( Coix lacryma-Joba L. ) and all-purpose flour to develop an improved convenience food product with high nutritional quality. All Purpose flour was added in different levels to Job's tear flour making four (4) treatments (0, 15, 30 and 45% w/w) in the production ...
Tópico(s): Microbial Metabolism and Applications
2019 - Science Publishing Group | American Journal of Biomedical and Life Sciences