Ángela Gutiérrez-Camino, Idoia Martín‐Guerrero, Vita Dolžan, Janez Jazbec, Ana Carbone-Bañeres, Nagore García de Andoín, Ana Méndez‐Echevarría, Itziar Astigarraga, Aurora Navajas, África García‐Orad,
... 3 , Ana Carbone-Bañeres 4 , Nagore Garcia de Andoin 5, 6 , Ana Sastre 7 , Itziar Astigarraga 8, ...
Tópico(s): Circular RNAs in diseases
2018 - Impact Journals LLC | Oncotarget
Julián Sevilla, Susana Navarro, Paula Rı́o, Rebeca Sánchez‐Domínguez, Josune Zubicaray, Eva Heredero Gálvez, Eva Merino, Elena Sebastián, Carmen Azqueta, José Antonio Casado, José C. Segovia, Omaira Alberquilla, Massimo Bogliolo, Francisco J Roman‐Rodriguez, Yari Giménez, Lise Larcher, Rocío Salgado, Roser Pujol, Raquel Hladun, Ana Pérez Castillo, Jean Soulier, Sergi Querol, Jesús Fernández‐Sojo, Jonathan D. Schwartz, Nagore García de Andoín, Ricardo López Almaraz, Albert Catalá, Jordi Surrallés, Cristina Díaz de Heredia, Juan A. Bueren,
Difficulties in the collection of hematopoietic stem and progenitor cells (HSPCs) from Fanconi anemia (FA) patients have limited the gene therapy in this disease.We have investigated (ClinicalTrials.gov,NCT02931071) the safety and efficacy of filgrastim and plerixafor for mobilization of HSPCs and collection by leukapheresis in FA patients.Nine of eleven enrolled patients mobilized beyond the threshold level of 5 CD34 + cells/mL required to initiate apheresis.A median of 21.8 CD34 + cells/mL was reached ...
Tópico(s): DNA Repair Mechanisms
2021 - Cell Press | Molecular Therapy — Methods & Clinical Development
Juan Carrillo-Reixach, Laura Torrens, Marina Simon‐Coma, Laura Royo, Montserrat Domingo-Sàbat, Jordi Abril‐Fornaguera, Nicholas K. Akers, María Sala, S. Ragull, Magdalena Arnal, Núria Villalmanzo, Stefano Cairo, Alberto Villanueva, Roland Kappler, Marta Garrido, Laura Guerra, Constantino Sábado, Gabriela Guillén, Mar Mallo, David Piñeyro, Maria Vázquez‐Vitali, Olga Kuchuk, María Elena Mateos, Gema Ramírez, Manuel Santamarı́a, Yasmina Mozo, Aroa Soriano, Michael Grotzer, Sophie Branchereau, Nagore García de Andoín, Blanca López‐Ibor, Ricardo López Almaraz, José Antonio Salinas, Bárbara Torres, F Hernández, José Javier Uriz, Monique Fabrè, Julià Blanco, Claudia Paris, Viera Bajčiová, Geneviève Laureys, Helena Masnou, Ariadna Clos, Cristina Beléndez, Catherine Guettier, Lauro Sumoy, Ramón Planas, Mireia Jordà, Lara Nonell, Piotr Czauderna, Bruce Morland, Daniela Sia, Bojan Losic, Marie Annick Buendia, Maria‐Rosa Sarrias, Josep M. Llovet, Carolina Armengol,
Hepatoblastoma (HB) is a rare disease. Nevertheless, it is the predominant pediatric liver cancer, with limited therapeutic options for patients with aggressive tumors. Herein, we aimed to uncover the mechanisms of HB pathobiology and to identify new biomarkers and therapeutic targets in a move towards precision medicine for patients with advanced HB.We performed a comprehensive genomic, transcriptomic and epigenomic characterization of 159 clinically annotated samples from 113 patients with HB, ...
Tópico(s): MicroRNA in disease regulation
2020 - Elsevier BV | Journal of Hepatology
Francisco Javier Ruano, Maria Luisa Somoza Álvarez, Elisa Haroun‐Díaz, María Vázquez de la Torre, Paula López González, Ana Prieto-Moreno, Isabel Torres Rojas, María Desamparados Cervera García, Diana Pérez Alzate, Natalia Blanca‐López, Gabriela Canto Díez,
... Monge R. Morales Suárez-Varela M. García de Andoin N. Batlles-Garrido J. et al.Geographic variation ...
Tópico(s): Asthma and respiratory diseases
2020 - Elsevier BV | The Journal of Allergy and Clinical Immunology In Practice
Hiroyuki Murai, Akiyuki Uzawa, Yasushi Suzuki, Tomihiro Imai, Hirokazu Shiraishi, Hidekazu Suzuki, Meinoshin Okumura, Fanny O’Brien, Jingjing Wang, Kenji P. Fujita, Kimiaki Utsugisawa, Claudio Mazia, Miguel Wilken, Fábio Barroso, Juliet Saba, Marcelo Rugiero, Mariela Bettini, Marcelo Chaves, Gonzalo Vidal, Alejandra Dalila Garcia, Jan De Bleecker, Guy Van den Abeele, Kathy de Koning, Katrien De Mey, Rudy Mercelis, Délphine Mahieu, Linda Wagemaekers, Philip Van Damme, Annelies Depreitere, Caroline Schotte, Charlotte Smetcoren, Olivier Stevens, Sien Van Daele, Nicolas Vandenbussche, Annelies Vanhee, Sarah Verjans, Jan Vynckier, Ann D’Hondt, Petra Tilkin, Alzira Alves de Siqueira Carvalho, Igor Dias Brockhausen, David Feder, Daniel Ambrosio, Pamela César, Ana Paula Souto Melo, Renata Martins Ribeiro, Rosana Rocha, Bruno Bezerra Rosa, Thabata Veiga, Luiz Augusto da Silva, Murilo Santos Engel, Jordana Gonçalves Geraldo, Maria da Penha Ananias Morita, Érica Coelho, Gabriel Pina Paiva, M Tovar Pozo, Natalia Prando, Debora Dada Martineli Torres, Cristiani Fernanda Butinhao, Gustavo Duran, Tamires Cristina Gomes da Silva, Luiz Otavio Maia Gonçalves, Lucas Eduardo Pazetto, Tomás Augusto Suriane Fialho, Luciana Renata Cubas Volpe, Luciana Souza Duca, Acary Souza Bullé Oliveira, Ana Carolina Amaral de Andrade, Marcelo Annes, Liene Duarte Silva, Valéria Cavalcante Lino, Wladimir Bocca Vieira de Rezende Pinto, Natália Assis, Fernanda Carrara, Carolina Miranda, Iandra Souza, Ana Patrícia Fernandes, Zaeem A. Siddiqi, Cecile Phan, Jeffrey Narayan, Derrick Blackmore, Ashley Mallon, Rikki Roderus, Elizabeth Watt, Jana Junkerová, Barbora Kurková, Katarína Reguliová, Olga Zapletalová, Jiří Piťha, Iveta Nováková, Michaela Týblová, Ivana Jurajdova, Marcela Wolfova, Henning Andersen, Thomas Harbo, Lotte Vinge, Susanne Krogh, Anita Mogensen, John Vissing, Joan Højgaard, Nanna Witting, Anne Mette Ostergaard Autzen, Jane Pedersen, Juha-Pekka Erälinna, Mikko Laaksonen, Olli Oksaranta, Tuula Harrison, Jaana Eriksson, Csilla Rózsa, Melinda Horvath, Gábor Lovas, Judit Matolcsi, G Szabó, Gedeonne Jakab, Brigitta Szabadosne, Giovanni Antonini, Antonella Di Pasquale, Matteo Garibaldi, Stefania Morino, Fernanda Troili, Laura Fionda, A Filla, Teresa Costabile, Enrico Marano, Francesco Saccà, Angiola Maria Fasanaro, Angela Marsili, Giorgia Puorro, Renato Mantegazza, Carlo Antozzi, Silvia Bonanno, Giorgia Camera, Alberta Locatelli, Lorenzo Maggi, Maria Barbara Pasanisi, Angela Campanella, Amelia Evoli, Paolo Emilio Alboini, Valentina Damato, Raffaele Iorio, Tetsuya Kanai, Naoki Kawaguchi, Masahiro Mori, Yoko Kaneko, Akiko Kanzaki, Eri Kobayashi, Katsuhisa Masaki, Dai Matsuse, Takuya Matsushita, Taira Uehara, Misa Shimpo, Maki Jingu, Keiko Kikutake, Yumiko Nakamura, Yoshiko Sano, Yuriko Nagane, Ikuko Kamegamori, Tomoko Tsuda, Yuko Fujii, Kazumi Futono, Yukiko Ozawa, Aya Mizugami, Yuka Saito, Miyuki Morikawa, Makoto Samukawa, Sachiko Kamakura, Eriko Miyawaki, Teiichiro Mitazaki, Masakatsu Motomura, Akihiro Mukaino, Shunsuke Yoshimura, Shizuka Asada, Seiko Yoshida, Shoko Amamoto, Tomomi Kobashikawa, Megumi Koga, Yasuko Maeda, Kazumi Takada, Mihoko Takada, Masako Tsurumaru, Yumi Yamashita, Tetsuya Akiyama, Koichi Narikawa, Ohito Tano, Kenichi Tsukita, Rikako Kurihara, Fumie Meguro, Yusuke Fukuda, Miwako Sato, Soichiro Funaka, Tomohiro Kawamura, Masayuki Makamori, Masanori Takahashi, Namie Taichi, Tomoya Hasuike, Eriko Higuchi, Hisako Kobayashi, Kaori Osakada, Emiko Tsuda, Shun Shimohama, Takashi Hayashi, Shin Hisahara, Jun Kawamata, Takashi Murahara, Masaki Saitoh, Shu-Ichiro Suzuki, Daisuke Yamamoto, Yoko Ishiyama, Naoko Ishiyama, Mayuko Noshiro, Rumi Takeyama, Kaori Uwasa, Ikuko Yasuda, Anneke J. van der Kooi, Marianne de Visser, Tamar Gibson, Carlos Casasnovas, Maria Antònia Albertí Aguiló, Christian Homedes-Pedret, Natalia Juliá Palacios, Laura Diez Porras, Valentina Santamaria, A. M. Lázaro, Exuperio Díez–Tejedor, Pilar Gomez Salcedo, Mireya Fernández-Fournier, Pedro Lopez Ruiz, Francisco Javier Rodríguez de Rivera Garrido, María Sastre, Josep Gámez, Pilar Suñé, María Salvadó, Gisela Gili, Gonzalo Mazuela, Isabel Illa, Elena Cortés Vicente, Jordi Díaz‐Manera, Luis Antonio Querol Gutiérrez, Ricardo Rojas Garcia, Núria Vidal, Elisabet Arribas-Ibar, Fredrik Piehl, Albert Hietala, Lena Bjarbo, İhsan Şükrü Şengün, Arzu Meherremova, Pınar Özçelik, Bengu Balkan, Celal Tuga, Müzeyyen Ugur, Sevim Erdem‐Özdamar, Can Ebru Bekircan‐Kurt, Nazire Pınar Acar, Ezgi Yılmaz, Yagmur Caliskan, Gulsah Orsel, Hüsnü Efendi, S. Aydınlık, Hakan Çavuş, Ayşe Kutlu, Gulsah Becerikli, Cansu Semiz, Ozlem Tun, Murat Terzi, Baki Doğan, Musa Onar, Sedat Şen, Tugce Kirbas Cavdar, Adife Veske, Fiona Norwood, Aikaterini Dimitriou, Jakit Gollogly, Mohamed Mahdi‐Rogers, Arshira Seddigh, Giannis Sokratous, Gal Maier, Faisal Sohail, Saiju Jacob, Girija Sadalage, Pravin Torane, Claire Brown, Amna Shah, Sivakumar Sathasivam, Heike Arndt, Debbie Davies, Dave Watling, Anthony Amato, Tom Cochrane, Mohammed Salajegheh, Kristen Roe, Katherine Amato, Shirli Toska, Gil I. Wolfe, Nicholas J. Silvestri, Kara Patrick, Karen Zakalik,
The terminal complement inhibitor eculizumab was shown to improve myasthenia gravis-related symptoms in the 26-week, phase 3, randomized, double-blind, placebo-controlled REGAIN study (NCT01997229). In this 52-week sub-analysis of the open-label extension of REGAIN (NCT02301624), eculizumab's efficacy and safety were assessed in 11 Japanese and 88 Caucasian patients with anti-acetylcholine receptor antibody-positive refractory generalized myasthenia gravis. For patients who had received placebo during ...
Elsevier BV
Henning Andersen, Renato Mantegazza, Jing Jing Wang, Fanny O’Brien, Kaushik Patra, James F. Howard, Claudio Mazia, Miguel Wilken, Fábio Barroso, Juliet Saba, Marcelo Rugiero, Mariela Bettini, Marcelo Chaves, Gonzalo Vidal, Alejandra Dalila Garcia, Jan De Bleecker, Guy Van den Abeele, Kathy de Koning, Katrien De Mey, Rudy Mercelis, Délphine Mahieu, Linda Wagemaekers, Philip Van Damme, Annelies Depreitere, Caroline Schotte, Charlotte Smetcoren, Olivier Stevens, Sien Van Daele, Nicolas Vandenbussche, Annelies Vanhee, Sarah Verjans, Jan Vynckier, Ann D’Hondt, Petra Tilkin, Alzira Alves de Siqueira Carvalho, Igor Dias Brockhausen, David Feder, Daniel Ambrosio, Pamela César, Ana Paula Souto Melo, Renata Martins Ribeiro, Rosana Rocha, Bruno Bezerra Rosa, Thabata Veiga, Luiz Augusto da Silva, Murilo Santos Engel, Jordana Gonçalves Geraldo, Maria da Penha Ananias Morita, Érica Coelho, Gabriel Pina Paiva, M Tovar Pozo, Natalia Prando, Debora Dada Martineli Torres, Cristiani Fernanda Butinhao, Gustavo Duran, Tamires Cristina Gomes da Silva, Luiz Otavio Maia Gonçalves, Lucas Eduardo Pazetto, Tomás Augusto Suriane Fialho, Luciana Renata Cubas Volpe, Luciana Souza Duca, Maurício Friedrich, Alexandre Guerreiro, Henrique Mohr, Maurer Pereira Martins, Daiane da Cruz Pacheco, Luciana Ferreira, Ana Paula Macagnan, Graziela Hünning Pinto, Aline de Cassia Santos, Acary Souza Bullé Oliveira, Ana Carolina Amaral de Andrade, Marcelo Annes, Liene Duarte Silva, Valéria Cavalcante Lino, Wladimir Bocca Vieira de Rezende Pinto, Natália Assis, Fernanda Carrara, Carolina Miranda, Iandra Souza, Ana Patrícia Fernandes, Zaeem A. Siddiqi, Cecile Phan, Jeffrey Narayan, Derrick Blackmore, Ashley Mallon, Rikki Roderus, Elizabeth Watt, Stanislav Voháňka, Josef Bednařík, Magda Chmelikova, Marek Čierny, Stanislava Toncrova, Jana Junkerová, Barbora Kurková, Katarína Reguliová, Olga Zapletalová, Jiří Piťha, Iveta Nováková, Michaela Týblová, Ivana Jurajdova, Marcela Wolfova, Thomas Harbo, Lotte Vinge, Susanne Krogh, Anita Mogensen, John Vissing, Joan Højgaard, Nanna Witting, Anne Ostergaard Autzen, Jane Pedersen, Juha-Pekka Erälinna, Mikko Laaksonen, Olli Oksaranta, Tuula Harrison, Jaana Eriksson, Csilla Rózsa, Melinda Horvath, Gábor Lovas, Judit Matolcsi, G Szabó, Gedeonne Jakab, Brigitta Szabadosne, László Vécsei, Lívia Dézsi, Edina Varga, Monika Konyane, Giovanni Antonini, Antonella Di Pasquale, Matteo Garibaldi, Stefania Morino, Fernanda Troili, Laura Fionda, A Filla, Teresa Costabile, Enrico Marano, Francesco Saccà, Angiola Maria Fasanaro, Angela Marsili, Giorgia Puorro, Carlo Antozzi, Silvia Bonanno, Giorgia Camera, Alberta Locatelli, Lorenzo Maggi, Maria Barbara Pasanisi, Angela Campanella, Amelia Evoli, Paolo Emilio Alboini, Valentina Damato, Raffaele Iorio, Maurizio Inghilleri, Laura Fionda, Vittorio Frasca, Elena Giacomelli, Maria Cristina Gori, Diego Lopergolo, Emanuela Onesti, Vittorio Frasca, Maria Gabriele, Akiyuki Uzawa, Tetsuya Kanai, Naoki Kawaguchi, Masahiro Mori, Yoko Kaneko, Akiko Kanzaki, Eri Kobayashi, Hiroyuki Murai, Katsuhisa Masaki, Dai Matsuse, Takuya Matsushita, Taira Uehara, Misa Shimpo, Maki Jingu, Keiko Kikutake, Yumiko Nakamura, Yoshiko Sano, Kimiaki Utsugisawa, Yuriko Nagane, Ikuko Kamegamori, Tomoko Tsuda, Yuko Fujii, Kazumi Futono, Yukiko Ozawa, Aya Mizugami, Yuka Saito, Hidekazu Suzuki, Miyuki Morikawa, Makoto Samukawa, Sachiko Kamakura, Eriko Miyawaki, Hirokazu Shiraishi, Teiichiro Mitazaki, Masakatsu Motomura, Akihiro Mukaino, Shunsuke Yoshimura, Shizuka Asada, Seiko Yoshida, Shoko Amamoto, Tomomi Kobashikawa, Megumi Koga, Yasuko Maeda, Kazumi Takada, Mihoko Takada, Masako Tsurumaru, Yumi Yamashita, Yasushi Suzuki, Tetsuya Akiyama, Koichi Narikawa, Ohito Tano, Kenichi Tsukita, Rikako Kurihara, Fumie Meguro, Yusuke Fukuda, Miwako Sato, Meinoshin Okumura, Soichiro Funaka, Tomohiro Kawamura, Masayuki Makamori, Masanori Takahashi, Namie Taichi, Tomoya Hasuike, Eriko Higuchi, Hisako Kobayashi, Kaori Osakada, Tomihiro Imai, Emiko Tsuda, Shun Shimohama, Takashi Hayashi, Shin Hisahara, Jun Kawamata, Takashi Murahara, Masaki Saitoh, Shu-Ichiro Suzuki, Daisuke Yamamoto, Yoko Ishiyama, Naoko Ishiyama, Mayuko Noshiro, Rumi Takeyama, Kaori Uwasa, Ikuko Yasuda, Anneke J. van der Kooi, Marianne de Visser, Tamar Gibson, Byung‐Jo Kim, Chang Nyoung Lee, Yong Seo Koo, Hung Youl Seok, Hoo Nam Kang, HyeJin Ra, Byoung Joon Kim, Eun Bin Cho, Misong Choi, HyeLim Lee, Ju‐Hong Min, Jinmyoung Seok, Ji-Eun Lee, Da Yoon Koh, JuYoung Kwon, SangAe Park, Eun Hwa Choi, Yoon‐Ho Hong, Sohyun Ahn, Dae Lim Koo, Jae‐Sung Lim, Chaewon Shin, Ji Ye Hwang, Miri Kim, Seung Min Kim, Ha-Neul Jeong, Jin-Woo Jung, Yool-hee Kim, Hyung‐Seok Lee, Ha Young Shin, Eun Bi Hwang, Miju Shin, Carlos Casasnovas, Maria Antònia Albertí Aguiló, Christian Homedes-Pedret, Natalia Juliá Palacios, Laura Diez Porras, Valentina Vélez-Santamaría, A. M. Lázaro, Exuperio Díez–Tejedor, Pilar Gomez Salcedo, Mireya Fernández-Fournier, Pedro Lopez Ruiz, Francisco Javier Rodríguez de Rivera Garrido, María Sastre, Josep Gámez, Pilar Suñé, María Salvadó, Gisela Gili, Gonzalo Mazuela, Isabel Illa, Elena Cortés Vicente,
To evaluate the effect of eculizumab on perceived fatigue in patients with anti-acetylcholine receptor antibody-positive, refractory, generalized myasthenia gravis (MG) using the Quality of Life in Neurological Disorders (Neuro-QOL) Fatigue subscale, and to evaluate correlations between improvements in Neuro-QOL Fatigue and other clinical endpoints.Neuro-QOL Fatigue, MG Activities of Daily Living (MG-ADL), Quantitative MG (QMG), and the 15-item MG Quality of Life (MG-QOL15) scales were administered during ...
Springer Science+Business Media
Paula Rı́o, Susana Navarro, Wei Wang, Rebeca Sánchez‐Domínguez, Roser Pujol, José C. Segovia, Massimo Bogliolo, Eva Merino, Ning Wu, Rocío Salgado, María L. Lamana, Rosa María Pérez Yáñez, José Antonio Casado, Yari Giménez, Francisco J Roman‐Rodriguez, Lara Álvarez, Omaira Alberquilla, Anna Raimbault, Guillermo Güenechea, M. Luz Lozano, Laura Cerrato, Miriam Hernando-Rodríguez, Eva Heredero Gálvez, Raquel Hladun, Irina Giralt, Jordi Barquinero, Anne Galy, Nagore García de Andoín, Ricardo López Almaraz, Albert Catalá, Jonathan D. Schwartz, Jordi Surrallés, Jean Soulier, Manfred Schmidt, Cristina Díaz de Heredia, Julián Sevilla, Juan A. Bueren,
Tópico(s): Genetic Neurodegenerative Diseases
2019 - Nature Portfolio | Nature Medicine
Ángela Gutiérrez-Camino, Idoia Martín‐Guerrero, Nagore García de Andoín, Ana Méndez‐Echevarría, Ana Carboné Bañeres, Itziar Astigarraga, Aurora Navajas, África García‐Orad,
The locus CDKN2A/B (9p21.3), which comprises the tumor suppressors genes CDKN2A and CDKN2B and the long noncoding RNA (lncRNA) known as ANRIL (or CDKN2B-AS), was associated with childhood acute lymphoblastic leukemia (ALL) susceptibility in several genome wide association studies (GWAS). However, the variants associated in the diverse studies were different. Recently, new and independent SNPs deregulating the locus function were also identified in association with ALL risk. This diversity in the results ...
Tópico(s): Epigenetics and DNA Methylation
2017 - Public Library of Science | PLoS ONE
James F. Howard, Kimiaki Utsugisawa, Michael Benatar, Hiroyuki Murai, Richard J. Barohn, Isabel Illa, Saiju Jacob, John Vissing, Ted M. Burns, John T. Kissel, Srikanth Muppidi, Richard J. Nowak, Fanny O’Brien, Jingjing Wang, Renato Mantegazza, Claudio Mazia, Miguel Wilken, Carolina Ortea, Juliet Saba, Marcelo Rugiero, Mariela Bettini, Gonzalo Vidal, Alejandra Dalila Garcia, Phillipa J. Lamont, Wai Yie Leong, Heidi Boterhoven, Beverly Fyfe, L. Jackson Roberts, Mahi Jasinarachchi, Natasha Willlems, Julia Wanschitz, Wolfgang N. Löscher, Jan De Bleecker, Guy Van den Abeele, Kathy de Koning, Katrien De Mey, Rudy Mercelis, Linda Wagemaekers, Délphine Mahieu, Philip Van Damme, Charlotte Smetcoren, Olivier Stevens, Sarah Verjans, Ann D’Hondt, Petra Tilkin, Alzira Alves de Siqueira Carvalho, Rosa Hasan, Igor Dias Brockhausen, David Feder, Daniel Ambrosio, Ana Paula Souto Melo, Rosana Rocha, Bruno Bezerra Rosa, Thabata Veiga, Luiz Augusto da Silva, Jordana Gonçalves Geraldo, Maria da Penha Morita Ananias, Érica Coelho, Gabriel Pina Paiva, M Tovar Pozo, Natalia Prando, Debora Dada Martineli Torres, Cristiani Fernanda Butinhao, Érica Coelho, Luciana Renata Cubas Volpe, Gustavo Duran, Tamires Cristina Gomes da Silva, Luiz Otavio Maia Gonçalves, Lucas Eduardo Pazetto, Luciana Souza Duca, Tomás Augusto Suriane Fialho, Maurício Friedrich, Alexandre Guerreiro, Henrique Mohr, Maurer Pereira Martins, Daiane da Cruz Pacheco, Ana Paula Macagnan, Aline de Cassia Santos, Acary Souza Bullé Oliveira, Ana Carolina Amaral de Andrade, Marcelo Annes, Valéria Cavalcante Lino, Wladimir Bocca Vieira de Rezende Pinto, Carolina Miranda, Fernanda Carrara, Iandra Souza, Angela Genge, Rami Massie, Natasha Campbell, Vera Bril, Hans Katzberg, Mehran Soltani, Eduardo Ng, Zaeem A. Siddiqi, Celile Phan, Derrick Blackmore, Stanislav Voháňka, Josef Bednařík, Magda Chmelikova, Marek Čierny, Stanislava Toncrova, Jana Junkerová, Barbora Kurková, Katarína Reguliová, Olga Zapletalová, Jiří Piťha, Iveta Nováková, Michaela Týblová, Marcela Wolfova, Ivana Jurajdova, Henning Andersen, Thomas Harbo, Lotte Vinge, Anita Mogensen, Joan Højgaard, Nanna Witting, Anne Mette Ostergaard Autzen, Jane Pedersen, Martti Färkkilâ, Sari Atula, Anne Nyrhinen, Juha-Pekka Erälinna, Mikko Laaksonen, Olli Oksaranta, Jaana Eriksson, Tuula Harrison, Claude Desnuelle, Sabrina Sacconi, Marie‐Hélène Soriani, Sonia Decressac, Julie Moutarde, Pauline Lahaut, Guilhem Solé, Gwendal Le Masson, Anne-Cécile Wielanek-Bachelet, Morgane Gaboreau, Caroline Moreau, Amy Wilson, Christophe Vial, Françoise Bouhour, H. Gervais-Bernard, H Merle, Caroline Hourquin, Arnaud Lacour, Olivier Outteryck, Patrick Vermersch, Hélène Zéphir, Edouard Millois, Michel Deneve, Fabienne Deruelle, Benedikt Schoser, Stephan Wenninger, Martin Stangel, Sascha Alvermann, Stefan Gingele, Thomas Skripuletz, Kurt-Wolfram Suehs, Corinna Trebst, Karin Fricke, Sotirios Papagiannopoulos, Sevasti Bostantzopoulou, Nicholas Vlaikidis, Martha Zampaki, Nikoletta Papadopoulou, Dimos D. Mitsikostas, Eleni Kasioti, Efstathia Mitropoulou, Despoina Charalambous, Csilla Rózsa, Melinda Horvath, Gábor Lovas, Judit Matolcsi, G Szabó, Brigitta Szabadosne, László Vécsei, Lívia Dézsi, Edina Varga, Monika Konyane, Bella Gross, Olga Azrilin, Nelly Greenbereg, H Kuperman, Giovanni Antonini, Matteo Garibaldi, Stefania Morino, Fernanda Troili, Antonella Di Pasquale, Alessandro Filla, Teresa Costabile, Enrico Marano, Francesco Saccà, Angela Marsil, Giorgia Puorro, Michelangelo Maestri Tassoni, Anna De Rosa, Silvia Bonanno, Carlo Antozzi, Lorenzo Maggi, Angela Campanella, C. Angelini, Paola Cudia, Valentina Pegoraro, Elena Pinzan, Francesca Bevilacqua, D. Orrico, Domenico Marco Bonifati, Amelia Evoli, Paolo Emilio Alboini, Valentina Damato, Raffaele Iorio, Maurizio Inghilleri, Laura Fionda, Vittorio Frasca, Elena Giacomelli, Maria Cristina Gori, Diego Lopergolo, Emanuela Onesti, Maria Gabriele, Francesco Patti, Andrea Caramma, Silvia Messina, Ester Reggio, Cinzia Caserta, Akiyuki Uzawa, Tetsuya Kanai, Masahiro Mori, Yoko Kaneko, Akiko Kanzaki, Eri Kobayashi, Katsuhisa Masaki, Dai Matsuse, Takuya Matsushita, Taira Uehara, Misa Shimpo, Maki Jingu, Keiko Kikutake, Yumiko Nakamura, Yoshiko Sano, Yuriko Nagane, Ikuko Kamegamori, Yuko Fujii, Kazumi Futono, Tomoko Tsuda, Yuka Saito, Hidekazu Suzuki, Miyuki Morikawa, Makoto Samukawa, Sachiko Kamakura, Hirokazu Shiraishi, Teiichiro Mitazaki, Masakatsu Motomura, Akihiro Mukaino, Shunsuke Yoshimura, Shizuka Asada, Tomomi Kobashikawa, Megumi Koga, Yasuko Maeda, Kazumi Takada, Mihoko Takada, Yumi Yamashita, Seiko Yoshida, Yasushi Suzuki, Tetsuya Akiyama, Koichi Narikawa, Kenichi Tsukita, Fumie Meguro, Yusuke Fukuda, Miwako Sato, Hidenori Matsuo, Takayasu Fukudome, Yuichiro Gondo, Yasuhiro Maeda, Akiko Nagaishi, Shunya Nakane, Yoshinori Okubo, Meinoshin Okumura, Soichiro Funaka, Tomohiro Kawamura, Masayuki Makamori, Masanori Takahashi, Tomoya Hasuike, Eriko Higuchi, Hisako Kobayashi, Kaori Osakada, Namie Taichi, Emiko Tsuda, Takashi Hayashi, Shin Hisahara, Tomihiro Imai, Jun Kawamata, Takashi Murahara, Masaki Saitoh, Shun Shimohama, Shu-Ichiro Suzuki, Daisuke Yamamoto, Shingo Konno,
Complement is likely to have a role in refractory generalised myasthenia gravis, but no approved therapies specifically target this system. Results from a phase 2 study suggested that eculizumab, a terminal complement inhibitor, produced clinically meaningful improvements in patients with anti-acetylcholine receptor antibody-positive refractory generalised myasthenia gravis. We further assessed the efficacy and safety of eculizumab in this patient population in a phase 3 trial.We did a phase 3, ...
Elsevier BV
Ángela Gutiérrez-Camino, Maitane Umerez, Idoia Martín‐Guerrero, Nagore García de Andoín, Borja Santos, Ana Méndez‐Echevarría, Aizpea Echebarria-Barona, Itziar Astigarraga, Aurora Navajas, África García‐Orad,
Tópico(s): Histone Deacetylase Inhibitors Research
2017 - Springer Nature | The Pharmacogenomics Journal
Leire Iparraguirre, Ángela Gutiérrez-Camino, Maitane Umerez, Idoia Martín‐Guerrero, Itziar Astigarraga, Aurora Navajas, Ana Méndez‐Echevarría, Nagore García de Andoín, África García‐Orad,
Methotrexate (MTX), the key drug in childhood B-cell acute lymphoblastic leukemia (B-ALL) therapy, often causes toxicity. An association between genetic variants in MTX transport genes and toxicity has been found. It is known that these transporters are regulated by microRNAs (miRNAs), and miRNA single nucleotide polymorphisms (SNPs) interfere with miRNA levels or function. With regard to B-cell ALL, we have previously found rs56103835 in miR-323b that targets ABCC4 associated with MTX plasma levels. ...
Tópico(s): Prenatal Screening and Diagnostics
2016 - Lippincott Williams & Wilkins | Pharmacogenetics and Genomics
Elixabet López-López, Ángela Gutiérrez-Camino, Itziar Astigarraga, Aurora Navajas, Aizpea Echebarria-Barona, Purificación García‐Miguel, Nagore García de Andoín, Carmen Lobo, Isabel Guerra‐Merino, Idoia Martín‐Guerrero, África García‐Orad,
Vincristine is an important component of acute lymphoblastic leukemia (ALL) treatment protocols that can cause neurotoxicity. Patients treated with LAL/SHOP protocols often suffer from vincristine-related neurotoxicity in early phases of treatment. Recently, a genome-wide association study connected a SNP in CEP72, involved in vincristine pharmacodynamics, with neurotoxicity during later phases of therapy, which was not replicated during induction phase. These results, together with previous studies ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2016 - Future Medicine | Pharmacogenomics
Ángela Gutiérrez-Camino, Elixabet López-López, Idoia Martín‐Guerrero, José Sánchez-Toledo, Nagore García de Andoín, Ana Carboné Bañeres, Purificación García‐Miguel, Aurora Navajas, África García‐Orad,
Tópico(s): Acute Lymphoblastic Leukemia research
2013 - Springer Science+Business Media | Journal of Cancer Research and Clinical Oncology
Elixabet López-López, Javier Ballesteros, M.A. Piñán, Joan Sánchez-de-Toledo, Nagore García de Andoín, Purificación García‐Miguel, Aurora Navajas, África García‐Orad,
Methotrexate (MTX) is an important component of therapy for pediatric acute lymphoblastic leukemia (ALL). Treatment with MTX often causes toxicity, which can necessitate dose reduction or treatment cessation. Interindividual differences in adverse reactions can be due to different factors, including polymorphisms in key genes. Recently, we confirmed the association between SLCO1B1 rs11045879 polymorphism and toxicity previously proposed by Treviño and colleagues. As SLCO1B1 is a transporter involved ...
Tópico(s): Chronic Myeloid Leukemia Treatments
2012 - Lippincott Williams & Wilkins | Pharmacogenetics and Genomics
Alberto Arnedo-Pena, Luis García‐Marcos, Jorge Fuertes Fernández-Espinar, Alberto Bercedo-Sanz, Ines Aguinaga‐Ontoso, Carlos González-Díaz, Ignacio Carvajal‐Urueña, Rosa María Busquet-Monge, María Morales‐Suárez‐Varela, Nagore García de Andoín, Juan Batlles-Garrido, Alfredo Blanco-Quirós, Ángel López-Silvarrey Varela, Gloria García‐Hernández,
Tópico(s): Climate Change and Health Impacts
2010 - Springer Science+Business Media | International Journal of Biometeorology
Luis García‐Marcos, José Batlles‐Garrido, Alfredo Blanco-Quirós, Gloria García‐Hernández, Francisco Guillén‐Grima, Carlos González-Díaz, A. García Merino, Alberto Arnedo-Pena, Rosa Busquets-Monge, María Morales‐Suárez‐Varela, Ángel López-Silvarrey-Varela, Nekane García-Andoin,
Tópico(s): Air Quality and Health Impacts
2008 - Springer Science+Business Media | International Journal of Biometeorology
Luis García‐Marcos, Alberto Arnedo Pena, Rosa Busquets-Monge, María Morales‐Suárez‐Varela, Nagore García de Andoín, José Batlles‐Garrido, Alfredo Blanco-Quirós, Ángel López-Silvarrey Varela, G. García‐Hernández, Ines Aguinaga‐Ontoso, Carlos González-Díaz, Águeda García-Merino,
The association between asthma and obesity in children, and the effect modification of allergy on this association have not been fully established. Aims The objective of the study was to know the effect modification of the severity of asthma and of the coexistence of rhinoconjunctivitis (RC) in the relationship between obesity and asthma.A cross-sectional study of 17 145 schoolchildren 6-7 years old from eight Spanish cities who had completed information on height and weight of the ISAAC phase III ...
Tópico(s): Respiratory and Cough-Related Research
2008 - Wiley | Clinical & Experimental Allergy
Ignacio Carvajal‐Urueña, Luis García‐Marcos, Rosa Busquets-Monge, M. Morales Suárez-Varela, Nagore García de Andoín, José Batlles‐Garrido, Alfredo Blanco-Quirós, Angel López-Silvarrey, G. García‐Hernández, Francisco Guillén‐Grima, Carlos González-Díaz, Juan B. Bellido‐Blasco,
TO analyze geographic variations in the prevalence of symptoms related to asthma in Spanish children and adolescents. In 2001 and 2002, the Spanish arm of the International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3 collected information on 28 445 children in the age bracket of 6-7 years in 10 metropolitan areas (A Coruña, Asturias, Barcelona, Bilbao, Cartagena, Castellón, Madrid, Pamplona, San Sebastián, and Valencia) and on 31 257 adolescents in the bracket 13-14 years in 11 areas ( ...
Tópico(s): Allergic Rhinitis and Sensitization
2005 - Elsevier BV | Archivos de Bronconeumología
Ignacio Carvajal‐Urueña, Luis García‐Marcos, Rosa Busquets-Monge, M. Morales Suárez-Varela, Nagore García de Andoín, José Batlles‐Garrido, Alfredo Blanco-Quirós, Angel López-Silvarrey, G. García‐Hernández, Francisco Guillén‐Grima, Carlos González-Díaz, Juan B. Bellido‐Blasco,
Analizar las variaciones geográficas en la prevalencia de síntomas relacionados con el asma en niños y adolescents españoles. Durante los años 2001 y 2002, el International Study of Asthma and Allergies in Childhood (ISAAC) fase III estudió a 28.445 niños de 6-7 años de 10 áreas (A Coruña, Asturias, Barcelona, Bilbao, Cartagena, Castellón, Madrid, Pamplona, San Sebastián y Valencia) y 31.257 adolescentes de 13-14 años de 11 áreas (las anteriores más Valladolid) españolas. Los síntomas de asma se recogieron ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2005 - Elsevier BV | Archivos de Bronconeumología
Alberto Arnedo-Pena, Luis García‐Marcos, Alfredo Blanco-Quirós, A. Martínez, Ines Aguinaga‐Ontoso, Carlos González Díaz, C.A. Díaz Vázquez, Rosa Busquets-Monge, María Morales‐Suárez‐Varela, José Batlles Garrido, Ángel López-Silvarrey Varela, Nagore García de Andoín,
Tópico(s): Respiratory and Cough-Related Research
2004 - Elsevier BV | Medicina Clínica
Catherine Andoins, Daniel de Fornel, Jocelyne Annat, Patrick Dutartre,
LF 08-0299 is a new immunosuppressive compound. In a fully mismatched rat cardiac allograft model (Dark Agouti [DA]-->Lewis [LEW]), long-term unresponsiveness was observed after LF 08-0299 short-term treatment (20 days). Survival of additional cardiac and skin DA allografts, and rejection of third-party (Brown Norway [BN]) skin allografts demonstrated induction of a donor-specific tolerance state. The aim of this study was to investigate mechanisms of cardiac acceptance in this model. LEW rats with long- ...
Tópico(s): Immune Cell Function and Interaction
1996 - Wolters Kluwer | Transplantation
Nerea Bilbao‐Aldaiturriaga, Ziortza Askaiturrieta, I. Granado-Tajada, Katja Goričar, Vita Dolžan, Purificación García‐Miguel, Nagore García de Andoín, Idoia Martín‐Guerrero, África García‐Orad,
Two polymorphisms in the murine double minute 2 (MDM2) gene (rs1690916 and rs2279744) have been associated with the risk of osteosarcoma (OS). When we analyzed these two polymorphisms in two new independents cohorts (Spanish and Slovenian), we found no association. In order to clarify this, we conducted a meta-analysis including six populations, with a total of 246 OS patients and 1,760 controls for rs1690916; and 433 OS patients and 1,959 controls for rs2279744. Pooled odds ratio risks and corresponding ...
Tópico(s): RNA Research and Splicing
2016 - Springer Nature | Pediatric Research
Idoia Martín‐Guerrero, Ángela Gutiérrez-Camino, Aizpea Echebarria-Barona, Itziar Astigarraga, Nagore García de Andoín, Aurora Navajas, África García‐Orad,
Tópico(s): Cancer therapeutics and mechanisms
2019 - Springer Nature | The Pharmacogenomics Journal
Andrea Di Cataldo, Antonella Agodi, Julia Balaguer, Alberto Garaventa, Martina Barchitta, Vanessa Segura, Maurizio Bianchi, Victoria Castel, Aurora Castellano, Simone Cesaro, José Miguel Couselo, Ofelia Cruz, Paolo D’Angelo, Bruno De Bernardi, J Donat, Nagore García de Andoín, Miguel Ángel Ibáñez-Hernández, M. La Spina, M.E. Lillo García, Ricardo López Almaraz, Roberto Luksch, Stefano Mastrangelo, Elena Mateos, José Manuel Molina, Carla Moscheo, Rosamaria Mura, Fulvio Porta, Giovanna Russo, Annalisa Tondo, Montserrat Torrent, Simona Vetrella, José Antonio Villegas Rubio, Elisabetta Viscardi, Giulio Andrea Zanazzo, Adela Cañete,
Tópico(s): Cancer therapeutics and mechanisms
2016 - Springer Science+Business Media | Clinical & Translational Oncology
Ángela Gutiérrez-Camino, Maitane Umerez, Elixabet López-López, Borja Santos-Zorrozúa, Idoia Martín‐Guerrero, Nagore García de Andoín, Sastre Ana, Aurora Navajas, Itziar Astigarraga, África García‐Orad,
Aim: Mucositis, linked to methotrexate, daunorubicin or cyclophosphamide, is a frequent childhood acute lymphoblastic leukemia (ALL) therapy side effect. miRNAs regulate the expression of pharmacokinetic/pharmacodynamic pathway genes. SNPs in miRNAs could affect their levels or function, and affect their pharmacokinetic/pharmacodynamic pathway target genes. Our aim was to determine the association between miRNA genetic variants targeting mucositis-related genes and mucositis-developing risk. Patients & ...
Tópico(s): Neonatal Health and Biochemistry
2018 - Future Medicine | Pharmacogenomics
Javier Úriz, Nagore García de Andoín, Cristina Calvo, Joseba Landa, Eider Oñate, A E Nogues, Rafael Guerrero,
... neutropenia.5 Javier Úriz, MD Nagore Garcia de Andoin, MD Cristina Calvo, MD Joseba Landa, MD Eider ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2007 - Lippincott Williams & Wilkins | The Pediatric Infectious Disease Journal
Produção Nacional
Revisado por pares
Lucas C. Céleri, Daniel Huerga, F. Albarrán-Arriagada, E. Solano, Mikel Garcia de Andoin, Mikel Sanz,
Simulating quantum many-body systems is a highly demanding task since the required resources grow exponentially with the dimension of the system. In the case of fermionic systems, this is even harder since nonlocal interactions emerge due to the antisymmetric character of the fermionic wave function. Here, we introduce a digital-analog quantum algorithm to simulate a wide class of fermionic Hamiltonians including the paradigmatic one-dimensional Fermi-Hubbard model. These digital-analog methods ...
Tópico(s): Quantum Information and Cryptography
2023 - American Physical Society | Physical Review Applied
Ángela Gutiérrez-Camino, Maitane Umerez, Borja Santos, Idoia Martín‐Guerrero, Nagore García de Andoín, Ana Méndez‐Echevarría, Aurora Navajas, Itziar Astigarraga, África García‐Orad,
Aim: Hepatotoxicity is one of the most common drug-related toxicities during the treatment of childhood acute lymphoblastic leukemia (ALL). Many genes involved in liver-specific signaling pathways are tightly controlled by miRNAs, and miRNA function could be modulated by SNPs. As a consequence, we hypothesized that variants in miRNAs could be associated with drug-induced hepatotoxicity. Methods: We analyzed 213 SNPs in 206 miRNAs in a cohort of 179 children with ALL homogeneously treated. Results: ...
Tópico(s): MicroRNA in disease regulation
2018 - Future Medicine | Epigenomics
Nagore García de Andoín, Juncal Echeverría, Ana María Cobo, Ángel Rey, Luis Paisán, Adolfo López de Munaín,
ObjectiveTo report a case of nonidentical twins affected with a congenital form of Steinert's myotonic dystrophy (DM1), conceived by IVF owing to parental sterility, in which the mother presented a paucisymptomatic form of DM1 which was diagnosed as a result of the condition inherited by the twins.DesignCase report.SettingNeonatal intensive care unit of a tertiary hospital.Patient(s)Newborn twins affected with the congenital form of DM1 and a 35-year-old nulliparous mother.Intervention(s)In vitro ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2005 - Elsevier BV | Fertility and Sterility
Mikel Garcia de Andoin, Álvaro Sáiz, P. Pérez-Fernández, Lucas Lamata, Izaskun Oregi, Mikel Sanz,
Digital-analog quantum computing is a computational paradigm which employs an analog Hamiltonian resource together with single-qubit gates to reach universality. Here, we design a new scheme which employs an arbitrary two-body source Hamiltonian, extending the experimental applicability of this computational paradigm to most quantum platforms. We show that the simulation of an arbitrary two-body target Hamiltonian of $n$ qubits requires $\mathcal{O}({n}^{2})$ analog blocks with guaranteed positive ...
Tópico(s): Quantum-Dot Cellular Automata
2024 - American Physical Society | Physical Review Research