Cédric Alaux, Nele Kemper, André Kretzschmar, Yves Le Conte,
Social removal is often an adaptive response for preventing the entry and spread of parasitic infection between kin members of a group. Social isolation via removal or the switching of social tasks has also been observed in insect societies; however, the underlying mechanisms are unclear. We tested in honeybees the role of the immune system in physiological and behavioral modulation. Forager bees are often located in the outer area of the colony, and thus have reduced contacts with individuals of ...
Tópico(s): Neurobiology and Insect Physiology Research
2012 - Elsevier BV | Brain Behavior and Immunity
Roberto Melero, Nele Hug, Andrés López‐Perrote, Akio Yamashita, Javier F. Cáceres, Óscar Llorca,
Abstract Nonsense-mediated decay (NMD) is a messenger RNA quality-control pathway triggered by SMG1-mediated phosphorylation of the NMD factor UPF1. In recent times, the RNA helicase DHX34 was found to promote mRNP remodelling, leading to activation of NMD. Here we demonstrate the mechanism by which DHX34 functions in concert with SMG1. DHX34 comprises two distinct structural units, a core that binds UPF1 and a protruding carboxy-terminal domain (CTD) that binds the SMG1 kinase, as shown using truncated ...
Tópico(s): RNA modifications and cancer
2016 - Nature Portfolio | Nature Communications
Sarah Meyer, Simon S. Kessner, Bastian Cheng, Marlene Bönstrup, Robert Schulz, Friedhelm C. Hummel, Nele De Bruyn, André Peeters, Vincent Van Pesch, Thierry Duprez, Stefan Sunaert, Maarten Schrooten, Hilde Feys, Christian Gerloff, Götz Thomalla, Vincent Thijs, Geert Verheyden,
The aim of this study was to investigate the relationship between stroke lesion location and the resulting somatosensory deficit. We studied exteroceptive and proprioceptive somatosensory symptoms and stroke lesions in 38 patients with first-ever acute stroke. The Erasmus modified Nottingham Sensory Assessment was used to clinically evaluate somatosensory functioning in the arm and hand within the first week after stroke onset. Additionally, more objective measures such as the perceptual threshold ...
Tópico(s): Vestibular and auditory disorders
2015 - Elsevier BV | NeuroImage Clinical
Kaja Kiiver, Ingrid Tagen, Eva Žusinaite, Nele Tamberg, John K. Fazakerley, Andres Merits,
Semliki Forest virus (SFV) non-structural protein 1 (nsP1) is a major component of the virus replicase complex. It has previously been studied in cells infected with virus or using transient or stable expression systems. To extend these studies, tetracycline-inducible stable cell lines expressing SFV nsP1 or its palmitoylation-negative mutant (nsP1 6D ) were constructed. The levels of protein expression and the subcellular localization of nsP1 in induced cells were similar to those in virus-infected ...
Tópico(s): Animal Disease Management and Epidemiology
2008 - Microbiology Society | Journal of General Virology
Elke Geuns, Nele De Temmerman, Pierre Hilven, André Van Steirteghem, Inge Liebaers, Martine De Rycke,
Imprinting is a non-Mendelian form of inheritance where epigenetic modifications control mono-allelic expression depending on the parental origin. Methylation of CpG-dinucleotides at differentially methylated regions (DMRs) is one of the best-studied mechanisms directing expression to one specific parental allele. We studied the methylation patterns of the intergenic (IG)-DMR of DLK1 and GTL2. The methylation marks of the IG-DMR were analysed in human gametes, preimplantation embryos, amniocytes and ...
Tópico(s): Genomic variations and chromosomal abnormalities
2007 - Springer Nature | European Journal of Human Genetics
Didier Snoeck, Pierre-André Smetryns, Nele De Belie,
Natural fibres such as flax and hemp fibres are mainly used in the textile industry, but some have outstanding mechanical properties and have a great potential as reinforcement in cementitious composites, as an alternative to synthetic microfibres. However, due to their hydrophilicity the amount of multiple cracking that occurs in cementitious composites reinforced with natural fibres is reduced. Also, natural fibres may degrade in alkaline environments. Therefore, proper mixtures and multiple chemical ...
Tópico(s): Innovations in Concrete and Construction Materials
2015 - Elsevier BV | Biosystems Engineering
Ruth Piers, Karen Versluys, Johan Devoghel, André Vyt, Nele Van Den Noortgate,
The complex health problems of older persons require that health professionals closely work together, in particular when an acute decline necessitates admission at an acute geriatric unit. These working conditions may cause additional stress in staff. This study aims to identify the relation between interprofessional teamwork, the quality of care and turnover intention in acute geriatric units.Perceptions of interprofessional teamwork, quality of care and turnover intention among team members of ...
Tópico(s): Nursing education and management
2018 - Elsevier BV | International Journal of Nursing Studies
Marius Schmitz, Sarah N. Back, K. Seitz, Nele K. Harbrecht, Lena Streckert, André Schulz, Sabine C. Herpertz, Katja Bertsch,
Deficient interoception, the processing and perception of internal bodily signals, has been discussed as a mechanism underlying various mental disorders. First results indicate a mediating role of interoception in the interplay of traumatic childhood experiences and adult mental disorders. Traumatic childhood experiences may hinder the adequate processing, integration, and trust in bodily signals that are important in order to understand and regulate own needs and emotions, thereby increasing the ...
Tópico(s): Mental Health and Psychiatry
2023 - BioMed Central | Borderline Personality Disorder and Emotion Dysregulation
Markus Raab, Rich S.W. Masters, J.P. Maxwell, André Arnold, Nele Schlapkohl, Jamie Poolton,
Abstract Discovery learning is believed to be an effective method for learning motor, anticipation, and cognitive skills, but the mechanisms leading to improvements are not well understood in the context of real‐life decisions in sports. There is no agreement on whether implicit or explicit learning processes underlie discovery learning. We compared the performances of four groups of participants in a basketball decision situation: Two groups received training in perceptual or cognitive discovery ...
Tópico(s): Motor Control and Adaptation
2009 - Taylor & Francis | International Journal of Sport and Exercise Psychology
Rudi Roose, André Mottart, Nele Dejonckheere, Carol van Nijnatten, Maria De Bie,
ABSTRACT Participation of children and parents is a central notion in child and family social work. This paper reports on a research dealing with how the participative paradigm comes to the fore in the practice of report writing in the work with looked‐after children. As social work is essentially a language‐centred activity, report writing is a core skill in social work. A participative practice of report writing would imply that the perspective of the children and parents is present in the reports. ...
Tópico(s): Research in Social Sciences
2009 - Wiley | Child & Family Social Work
Jürgen J. Heinisch, Ulf Buchwald, André Gottschlich, Nele Heppeler, Rosaura Rodicio,
A set of different marker deletions starting with a ura3 derivative of the Kluyveromyces lactis type strain CBS2359 was constructed. After a first cross to obtain a strain with the opposite mating type that also carried a leu2 allele, continuous back-crosses were used to obtain a congenic strain series with different marker combinations, including deletions in KlHIS3, KlADE2 and KlLAC4. Enzymes involved in carbohydrate metabolism were shown to behave very similarly to the original type strain and ...
Tópico(s): Fermentation and Sensory Analysis
2009 - Oxford University Press | FEMS Yeast Research
Sarah Meyer, Nele De Bruyn, Lena Krumlinde‐Sundholm, André Peeters, Hilde Feys, Vincent Thijs, Geert Verheyden,
Longitudinal information regarding the prevalence of upper limb somatosensory deficits and the association with motor impairment and activity limitations is scarce. The aim of this prospective cohort study was to map the extent and distribution of somatosensory deficits, and to determine associations over time between somatosensory deficits and motor impairment and activity limitations.We recruited 32 participants who were assessed 4 to 7 days after stroke, and reassessed at 6 months. Somatosensory ...
Tópico(s): Acute Ischemic Stroke Management
2016 - Lippincott Williams & Wilkins | Journal of Neurologic Physical Therapy
Elke Gasthuys, Andrés Montesinos, Nele Caekebeke, Mathias Devreese, Siegrid De Baere, María Ardiaca García, Dominique Paepe, Siska Croubels, Gunther Antonissen,
Abstract Early diagnosis of kidney diseases in avian species is limited. Endogenous markers currently used in avian practice are not sensitive enough to identify early kidney failure. Consequently, alternative markers should be evaluated. To be able to evaluate these alternative markers, an accurate marker to estimate the GFR should be validated. This study determined the GFR, measured as clearance of exogenous creatinine and exo-iohexol, in six different bird species, i.e. broiler chickens, laying ...
Tópico(s): Animal Ecology and Behavior Studies
2019 - Nature Portfolio | Scientific Reports
Nele Jacobs, Silvia M. A. A. Evers, André J.H.A. Ament, Nerée Claes,
Objectives: Little is known about the costs and the effects of cardiovascular prevention programs targeted at medical and behavioral risk factors. The aim was to evaluate the cost-utility of a cardiovascular prevention program in a general sample of highly educated adults after 1 year of intervention. Methods: The participants were randomly assigned to intervention ( n = 208) and usual care conditions ( n = 106). The intervention consisted of medical interventions and optional behavior-change interventions ( ...
Tópico(s): Health Policy Implementation Science
2010 - Cambridge University Press | International Journal of Technology Assessment in Health Care
Andrés López‐Perrote, Nele Hug, Ana González‐Corpas, Carlos F. Rodríguez, Marina Serna, Carmen García-Martín, Jasminka Boskovic, Rafael Fernández-Leiro, Javier F. Cáceres, Óscar Llorca,
Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that degrades aberrant mRNAs and also regulates the expression of a wide range of physiological transcripts. RUVBL1 and RUVBL2 AAA-ATPases form an hetero-hexameric ring that is part of several macromolecular complexes such as INO80, SWR1, and R2TP. Interestingly, RUVBL1-RUVBL2 ATPase activity is required for NMD activation by an unknown mechanism. Here, we show that DHX34, an RNA helicase regulating NMD initiation, directly interacts with ...
Tópico(s): RNA modifications and cancer
2020 - eLife Sciences Publications Ltd | eLife
Katrien Boon, Gabriele Bislenghi, André D’Hoore, Nele Boon, Albert Wolthuis,
Tópico(s): Colorectal Cancer Surgical Treatments
2020 - Springer Science+Business Media | Aging Clinical and Experimental Research
Sirle Saul, Mhairi C. Ferguson, Colette Cordonin, Rennos Fragkoudis, Margit Ool, Nele Tamberg, Karen Sherwood, John K. Fazakerley, Andres Merits,
The A7(74) strain of Semliki Forest virus (SFV; genus Alphavirus) is avirulent in adult mice, while the L10 strain is virulent in mice of all ages. It has been previously demonstrated that this phenotypic difference is associated with nonstructural protein 3 (nsP3). Consensus clones of L10 (designated SFV6) and A7(74) (designated A774wt) were used to construct a panel of recombinant viruses. The insertion of nsP3 from A774wt into the SFV6 backbone had a minor effect on the virulence of the resulting ...
Tópico(s): interferon and immune responses
2015 - American Society for Microbiology | Journal of Virology
Julia García-González, Tiago Barroqueiro, Luís Evangelista, Jorge de Brito, Nele De Belie, Julia Mͣ Morán-del Pozo, Andrés Juan-Valdés,
Tópico(s): Innovations in Concrete and Construction Materials
2016 - Springer Science+Business Media | Materials and Structures
Nele‐Charlotte Neddermann, Wolfgang A. Müller, Mikhail Dobrynin, André Düsterhus, Johanna Baehr,
We improve seasonal hindcast skill of European summer climate in an ensemble based coupled seasonal prediction system by selecting individual ensemble members based on their respective consistent chain of processes that describe a physical mechanism. This mechanism is associated with the second mode of seasonal climate variability in the North-Atlantic-European sector and is contrary to the summer North Atlantic Oscillation. We initially analyse the mechanism in the ERA-Interim reanalysis and then ...
Tópico(s): Oceanographic and Atmospheric Processes
2019 - Springer Science+Business Media | Climate Dynamics
Leonardo Boccuni, Sarah Meyer, Simon S. Kessner, Nele De Bruyn, Bea Essers, Bastian Cheng, Götz Thomalla, André Peeters, Stefan Sunaert, Thierry Duprez, Lucio Marinelli, Carlo Trompetto, Vincent Thijs, Geert Verheyden,
Background. Proportional motor recovery in the upper limb has been investigated, indicating about 70% of the potential for recovery of motor impairment within the first months poststroke. Objective. To investigate whether the proportional recovery rule is applicable for upper-limb somatosensory impairment and to study underlying neural correlates of impairment and outcome at 6 months. Methods. A total of 32 patients were evaluated at 4 to 7 days and 6 months using the Erasmus MC modification of ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2018 - SAGE Publishing | Neurorehabilitation and neural repair
Andres Männik, Kertu Rünkorg, Nele Jaanson, Mart Ustav, Ene Ustav,
ABSTRACT We have studied the replication of plasmids composed of bovine papillomavirus type 1 (BPV1) origin of replication and expression cartridges for viral proteins E1 and E2 in hamster and mouse cells. We found that the replication mode changed dramatically at different expression levels of the E1 protein. At high levels of the E1 protein, overreplication of the origin region of the plasmid was observed. Analysis of the replication products by one-dimensional and two-dimensional gel electrophoresis ...
Tópico(s): T-cell and Retrovirus Studies
2002 - American Society for Microbiology | Journal of Virology
Henry Völzke, André Werner, Henri Wallaschofski, Nele Friedrich, Daniel M. Robinson, Stefan Kindler, Matthias Kraft, Ulrich John, Wolfgang Hoffmann,
Context: The thyroid gland is a potential target organ for radiation-related damage. Objective: The aim of the analysis was to investigate the association between occupational exposure to ionizing radiation and autoimmune thyroid disease (AITD). Design: Our design was the cross-sectional Study of Health in Pomerania. Setting: The setting was the general community. Subjects: Analyses were performed in a population-based sample of 4299 subjects. Among them, 160 persons reported a history of occupational ...
Tópico(s): Radiation Dose and Imaging
2005 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Sabine Prezenski, André Brechmann, Susann Wolff, Nele Rußwinkel,
Decision-making is a high-level cognitive process based on cognitive processes like perception, attention, and memory. Real-life situations require series of decisions to be made, with each decision depending on previous feedback from a potentially changing environment. To gain a better understanding of the underlying processes of dynamic decision-making, we applied the method of cognitive modeling on a complex rule-based category learning task. Here, participants first needed to identify the conjunction ...
Tópico(s): Child and Animal Learning Development
2017 - Frontiers Media | Frontiers in Psychology
Michael Orthofer, Armand Valsesia, Reedik Mägi, Qiao‐Ping Wang, Joanna Kaczanowska, I. Kozieradzki, Alexandra Leopoldi, Domagoj Cikes, Lydia M. Zopf, Evgenii O. Tretiakov, Egon Demetz, Richard Hilbe, Anna Boehm, Melita Ticevic, Margit Nõukas, Alexander Jaïs, Katrin Spirk, Teleri Clark, Sabine Amann, Maarja Lepamets, Christoph Neumayr, Cosmas D. Arnold, Zhengchao Dou, Volker Kühn, Maria Novatchkova, Shane J. F. Cronin, Uwe J.F. Tietge, Simone Müller, J. Andrew Pospisilik, Vanja Nagy, Chi‐chung Hui, Jelena Lazović, Harald Esterbauer, Astrid Hagelkrüys, Ivan Tancevski, Florian W. Kiefer, Tibor Harkany, Wulf Haubensak, G. Gregory Neely, Andres Metspalu, Jörg Hager, Nele Gheldof, Josef Penninger,
There is considerable inter-individual variability in susceptibility to weight gain despite an equally obesogenic environment in large parts of the world. Whereas many studies have focused on identifying the genetic susceptibility to obesity, we performed a GWAS on metabolically healthy thin individuals (lowest 6th percentile of the population-wide BMI spectrum) in a uniquely phenotyped Estonian cohort. We discovered anaplastic lymphoma kinase (ALK) as a candidate thinness gene. In Drosophila, RNAi ...
Tópico(s): Genetic Associations and Epidemiology
2020 - Cell Press | Cell
Rennos Fragkoudis, Nele Tamberg, Ricky W. C. Siu, Kaja Kiiver, Alain Kohl, Andres Merits, John K. Fazakerley,
Tópico(s): interferon and immune responses
2009 - Springer Science+Business Media | Journal of NeuroVirology
Nele Jacobs, Ruben M. W. A. Drost, André J.H.A. Ament, Silvia M. A. A. Evers, Nerée Claes,
The aim of this study was to determine adults' Willingness To Pay (WTP) for CardioVascular Disease (CVD) intervention programs of different intensities.Three hundred fourteen participants were randomized to two study conditions: (i) CVD risk assessment/communication; (ii) CVD risk assessment/communication + a behavior change program. The behavior change program was aimed at increasing physical activity, reducing saturated fat intake and smoking cessation. It consisted of a tailored Web site and individual ...
Tópico(s): Obesity, Physical Activity, Diet
2011 - Cambridge University Press | International Journal of Technology Assessment in Health Care
Ruth Piers, Karen Versluys, Johan Devoghel, Sophie Lambrecht, André Vyt, Nele Van Den Noortgate,
Objectives To explore the quality of interprofessional teamwork in acute geriatric care and to build a model of team types. Design Cross‐sectional multicenter study. Setting Acute geriatric units in Belgium. Participants Team members of different professional backgrounds. Measurements Perceptions of interprofessional teamwork among team members of 55 acute geriatric units in Belgium were measured using a survey covering collaborative practice and experience, managerial coaching and open team culture, ...
Tópico(s): Family and Patient Care in Intensive Care Units
2017 - Wiley | Journal of the American Geriatrics Society
Julia García-González, Desirée Rodríguez-Robles, Jianyun Wang, Nele De Belie, Julia Mͣ Morán-del Pozo, M. Ignacio Guerra‐Romero, Andrés Juan-Valdés,
This research focuses on improving the quality of mixed and ceramic recycled aggregates by microbially induced carbonate precipitation (Bacillus sphaericus). The precipitation contributed to a weight increase and unleashed a waterproofing response. The roughness of the ceramic particles created a more uniform layer compared to natural or concrete particles. For the concrete fraction, which had a higher macroporosity, the consolidation effect was more pronounced. High ceramic content aggregates profited ...
Tópico(s): biodegradable polymer synthesis and properties
2017 - Elsevier BV | Construction and Building Materials
Valérie Turcot, Yingchang Lu, Heather M. Highland, Claudia Schurmann, Anne E. Justice, Rebecca S. Fine, Jonathan P. Bradfield, Tõnu Esko, Ayush Giri, Mariaelisa Graff, Xiuqing Guo, Audrey E. Hendricks, Tugce Karaderi, Adelheid Lempradl, Adam E. Locke, Anubha Mahajan, Eirini Marouli, Suthesh Sivapalaratnam, Kristin L. Young, Tamuno Alfred, Mary F. Feitosa, Nicholas G. D. Masca, Alisa K. Manning, Carolina Medina‐Gómez, Poorva Mudgal, Maggie C. Y. Ng, Alex P. Reiner, Sailaja Vedantam, Sara M. Willems, Thomas W. Winkler, Gonçalo R. Abecasis, Katja K.H. Aben, Dewan S Alam, Sameer Alharthi, Matthew Allison, Philippe Amouyel, Folkert W. Asselbergs, Paul L. Auer, Beverley Balkau, Lia E. Bang, Inês Barroso, Lisa Bastarache, Marianne Benn, Sven Bergmann, Lawrence F. Bielak, Matthias Blüher, Michael Boehnke, Heiner Boeing, Eric Boerwinkle, Carsten A. Böger, Jette Bork‐Jensen, Michiel L. Bots, Erwin P. Böttinger, Donald W. Bowden, Ivan Brandslund, Gerome Breen, Murray H. Brilliant, Linda Broer, Marco Brumat, Amber Burt, Adam S. Butterworth, Peter T. Campbell, Stefania Cappellani, David J. Carey, Eulalia Catamo, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Yii‐Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y. Chu, Massimiliano Cocca, Francis S. Collins, James P. Cook, Janie Corley, Jordi Corominas Galbany, Amanda J. Cox, David S. Crosslin, Gabriel Cuéllar-Partida, Angela D’Eustacchio, John Danesh, Gail Davies, Paul I. W. de Bakker, Mark de Groot, Renée de Mutsert, Ian J. Deary, George Dedoussis, Ellen W. Demerath, Martin den Heijer, Anneke I. den Hollander, Hester M. den Ruijter, Joe Dennis, Joshua C. Denny, Emanuele Di Angelantonio, Fotios Drenos, Mengmeng Du, Marie‐Pierre Dubé, Alison M. Dunning, Douglas F. Easton, Todd L. Edwards, David Ellinghaus, Patrick T. Ellinor, Paul Elliott, Εvangelos Εvangelou, Aliki‐Eleni Farmaki, I. Sadaf Farooqi, Jessica D. Faul, Sascha Fauser, Shuang Feng, Ele Ferrannini, Jean Ferrières, José C. Florez, Ian Ford, Myriam Fornage, Oscar H. Franco, André Franke, Paul W. Franks, Nele Friedrich, Ruth Frikke‐Schmidt, Tessel E. Galesloot, Wei Gan, Ilaria Gandin, Paolo Gasparini, Jane Whitney Gibson, Vilmantas Giedraitis, Anette P. Gjesing, Penny Gordon‐Larsen, Mathias Gorski, Hans J. Grabe, Struan F.A. Grant, Niels Grarup, Helen Griffiths, Megan L. Grove, Vilmundur Guðnason, Stefan Gustafsson, Jeff Haessler, Hákon Hákonarson, Anke R. Hammerschlag, Torben Hansen, Kathleen Mullan Harris, Tamara B. Harris, Andrew T. Hattersley, Henri Theil, Caroline Hayward, Liang He, Nancy L. Heard‐Costa, Andrew C. Heath, Iris M. Heid, Øyvind Helgeland, Jussi Hernesniemi, Alex W. Hewitt, Oddgeir L. Holmen, G. Kees Hovingh, Joanna M. M. Howson, Yao Hu, Paul L. Huang, Jennifer E. Huffman, M. Arfan Ikram, Erik Ingelsson, Anne Jackson, Jan‐Håkan Jansson, Gail P. Jarvik, Gorm Boje Jensen, Yucheng Jia, Stefan Johansson, Marit E. Jørgensen, Torben Jørgensen, J. Wouter Jukema, Bratati Kahali, René S. Kahn, Mika Kähönen, Pia R. Kamstrup, Stavroula Kanoni, Jaakko Kaprio, Maria Karaleftheri, Sharon L. R. Kardia, Fredrik Karpe, Sekar Kathiresan, Frank Kee, Lambertus A. Kiemeney, Eric H. Kim, Hidetoshi Kitajima, Pirjo Komulainen, Jaspal S. Kooner, Charles Kooperberg, Tellervo Korhonen, Péter Kovács, Helena Kuivaniemi, Zoltán Kutalik, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo A. Lakka, David Lamparter, Ethan M. Lange, Leslie A. Lange, Claudia Langenberg, Eric B. Larson, Sang Lee, Terho Lehtimäki, Cora E. Lewis, Huaixing Li, Jin Li, Ruifang Li‐Gao, Honghuang Lin, Keng‐Hung Lin, Li‐An Lin, Lin Xu, Lars Lind, Jaana Lindström, Allan Linneberg, Yongmei Liu, Dajiang J. Liu, Yongmei Liu, Ken Sin Lo, Artitaya Lophatananon, Andrew Lotery, Anu Loukola, Jian'an Luan, Steven A. Lubitz, Leo‐Pekka Lyytikäinen, Satu Männistö, Gaëlle Marenne, Angela L. Mazul, Mark I. McCarthy, Roberta McKean‐Cowdin, Sarah E. Medland, Karina Meidtner, Lili Milani, Vanisha Mistry, Paul Mitchell, Karen L. Mohlke, Leena Moilanen, Marie Moitry, Grant W. Montgomery, Dennis O. Mook‐Kanamori, Carmel Moore, Trevor A. Mori, Andrew D. Morris, Andrew P. Morris, Martina Müller‐Nurasyid, Patricia B. Munroe, Mike A. Nalls, Narisu Narisu, Christopher P. Nelson, Matt J. Neville, Sune F. Nielsen, Kjell Nikus, Pål R. Njølstad, Børge G. Nordestgaard, Dale R. Nyholt, Jeffrey R. O’Connel, Michelle L. O’Donoghue, Loes M. Olde Loohuis, Roel A. Ophoff, Katharine R. Owen, Chris J. Packard, Sandosh Padmanabhan, Nicholette D. Palmer, Nicholette D. Palmer, Gerard Pasterkamp, Aniruddh P. Patel, Alison Pattie, Oluf Pedersen, Peggy Peissig, Gina M. Peloso, Craig E. Pennell, Markus Perola, James A. Perry, John R. B. Perry, Tune H. Pers, Thomas N. Person, Annette Peters, Annette Peters, Patricia A. Peyser, Ailith Pirie, Ozren Polašek, Tinca J. C. Polderman, Hannu Puolijoki, Olli T. Raitakari, Asif Rasheed, Rainer Rauramaa, Dermot F. Reilly, Frida Renström, Myriam Rheinberger, Paul M. Ridker, John D. Rioux, Manuel A. Rivas, David J. Roberts, Neil R. Robertson, Antonietta Robino, Olov Rolandsson, Igor Rudan, Katherine S. Ruth, Danish Saleheen,
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants from which pinpointing causal genes remains challenging. Here we combined data from 718,734 individuals to discover rare and low-frequency (minor allele frequency (MAF) < 5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, ...
Nature Portfolio
Bea Essers, Sarah Meyer, Nele De Bruyn, Annick Van Gils, Leonardo Boccuni, Lisa Tedesco Triccas, André Peeters, Vincent Thijs, Hilde Feys, Geert Verheyden,
Purpose: To investigate the relation between observed and perceived upper limb motor function in patients with chronic stroke.Material and methods: We investigated 32 patients at six months after stroke with the Fugl-Meyer Assessment (observed function) and hand subscale of the Stroke Impact Scale (perceived function). Spearman correlation was calculated to relate observed and perceived function. Through cut-off scores, we divided our sample in low (Fugl-Meyer Assessment <31/66) and good observed function, ...
Tópico(s): Cerebral Palsy and Movement Disorders
2018 - Informa | Disability and Rehabilitation