Charles Pilette, Benoît Colinet, Róbert Kiss, Sabine André, Herbert Kaltner, Hans‐Joachim Gabius, Monique Delos, Jp. Vaerman, M. Decramer, Yves Sibille,
Galectins-1 and -3 regulate epithelial proliferation/apoptosis and neutrophil activation, and are implicated in lung cancer and asthma. The role of galectins in chronic obstructive pulmonary disease (COPD), characterised by epithelial changes and neutrophil infiltration, remains unknown. In the present study, galectin-1 and -3 expression was assessed by immunohistology in the bronchial epithelium of lung specimens from eight severe COPD patients and compared with nine nonsmokers and six smokers without ...
Tópico(s): Inflammation biomarkers and pathways
2007 - European Respiratory Society | European Respiratory Journal
Vincent Croquet, Christophe Pilette, Anne Lespine, E. Vuillemin, Marie Christine Rousselet, Frédéric Oberti, Jean-Paul Saint André, B. Périquet, Sylvie François, Norbert Ifrah, Paul Calès,
We report the case of a 32-year-old man with portal hypertension without cirrhosis due to chronic vitamin A intoxication. Portal hypertension revealed by oesophageal varice rupture progressively worsened and ascites occurred 5 years after the patient stopped vitamin A intake. Initially, serum retinyl palmitate concentration was increased whereas serum retinol concentration was normal. There was no hepatic fibrosis on light microscopic examination of liver biopsy specimens. Five years after the patient ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2000 - Lippincott Williams & Wilkins | European Journal of Gastroenterology & Hepatology
Catherine Lombard, Floriane André, Jérôme Paul, Catherine Wanty, Olivier Vosters, Pierre Bernard, Charles Pilette, Pierre Dupont, Étienne Sokal, Françoise Smets,
Background Allergy afflicts one third of children, negatively impacting their quality of life and generating a significant socio-economic burden. To this day, this disorder remains difficult to diagnose early in young patients, with no predictive test available. Objective This study was designed to correlate cytokine profiles with clinical phenotypes of allergy development. Methods Three hundred patients were recruited and followed from birth to 18 months of age. They were given a clinical exam ...
Tópico(s): Dermatology and Skin Diseases
2015 - Public Library of Science | PLoS ONE
... also correlates with histological scoring of fibrosis [[10]Pilette C. Rousselet M.C. Bedossa P. Chappard D. ... also correlates with histological scoring of fibrosis [[10]Pilette C. Rousselet M.C. Bedossa P. Chappard D. ... S. Dupre F. Croue A. Bedossa P. Saint-Andre J.P. et al.Sources of variability in ...
Tópico(s): Spectroscopy Techniques in Biomedical and Chemical Research
2010 - Elsevier BV | Journal of Hepatology
Alexandre Pariente, Jean‐Pierre Arpurt, André‐Jean Remy, I. Rosa-Hézode, Xavier Causse, Frédéric Heluwaert, Gilles Macaigne, Jean Henrion, Christophe Renou, Matthieu Schnee, Hatem Salloum, Séverine Hommel, Christophe Pilette, Ramuntxo Arotçarena, Georges Barjonet, Hortensia Lison, F. Bourhis, Vincent Jouannaud, Arnaud Pauwels, Yann Le eaBricquir, E Geagea, Bertrand Condat, Marie–Pierre Ripault, David Zanditenas, S. de Montigny-Lenhardt, H Labadie, Bertrand Tissot, E. Maringe, Jean–François Cadranel, Hervé Hagège, Bruno Lesgourgues,
According to clinical trials, the treatment of patients with chronic hepatitis C (CHC) with second-generation direct acting antiviral agents (DAAs) is highly efficient and well tolerated. The goal of this study was to investigate the effectiveness and safety of various combinations of these drugs during their first 2 years of use in the real-world practice of French general hospitals. Data from patients treated with all-oral DAAs in 24 French non-academic hospital centers from March 1, 2014 to January ...
Tópico(s): Liver Disease Diagnosis and Treatment
2019 - Elsevier BV | La Presse Médicale
Christophe Pilette, Bruno Bour, Bruno Lesgourgues, O Nouël, André‐Jean Remy, Frederic Helluwaert, Jean Henrion, Roger Faroux, Gilles Macaigne, C Naouri, David Bernardini, Guy Bellaïche, E A Pariente, Hervé Hagège,
Tópico(s): Gastrointestinal Bleeding Diagnosis and Treatment
2008 - Elsevier BV | Gastroenterology
Alexandre Pariente, Jean‐Pierre Arpurt, André‐Jean Remy, I. Rosa-Hézode, Xavier Causse, Frédéric Heluwaert, Gilles Macaigne, Jean Henrion, Christophe Renou, Matthieu Schnee, Hatem Salloum, Séverine Hommel, Christophe Pilette, Ramuntxo Arotçarena, Georges Barjonet, Hortensia Lison, Frangois Bourhis, Vincent Jouannaud, Arnaud Pauwels, Yann Le-Bricquir, E Geagea, Bertrand Condat, Marie–Pierre Ripault, David Zanditenas, S. de Montigny-Lenhardt, H Labadie, Bertrand Tissot, E. Maringe, Jean-Frangois Cadranel, Hervé Hagège, Bruno Lesgourgues,
Data on the efficacy and tolerance of interferon-free treatment in chronic hepatitis C (CHC) in elderly patients are limited in phase II-III trials. A prospective cohort of adult patients with CHC treated in French general hospitals. Data from 1,123 patients, distributed into four age groups, were analyzed. Of these, 278 were > 64 years old (fourth quartile) and 133 were > 73 years old (tenth decile). Elderly patients weighed less, were more frequently treatment-experienced women infected with genotype ...
Tópico(s): Liver Disease Diagnosis and Treatment
2018 - Elsevier BV | Annals of Hepatology
Catherine Lombard, Floriane André, Jérôme Paul, Catherine Wanty, Olivier Vosters, Pierre Bernard, Charles Pilette, Pierre Dupont, Étienne Sokal, Françoise Smets,
Tópico(s): Pediatric health and respiratory diseases
2014 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition
Alexandre Pariente, Jean‐Pierre Arpurt, André‐Jean Remy, I. Rosa-Hézode, Xavier Causse, Frédéric Heluwaert, Gilles Macaigne, Jean Henrion, Christophe Renou, Matthieu Schnee, Hatem Salloum, Séverine Hommel, Christophe Pilette, Ramuntxo Arotçarena, Georges Barjonet, Hortensia Lison, F. Bourhis, Vincent Jouannaud, Arnaud Pauwels, Yann Le-Bricquir, E Geagea, Bertrand Condat, Marie–Pierre Ripault, David Zanditenas, Stéphanie de Montigny Lenhardt, H Labadie, Bertrand Tissot, E. Maringe, Jean–François Cadranel, Hervé Hagège, Bruno Lesgourgues,
Introduction and aim: Data on the efficacy and tolerance of interferon-free treatment in chronic hepatitis C (CHC) in elderly patients are limited in phase II-III trials. Methods: A prospective cohort of adult patients with CHC treated in French general hospitals. Results: Data from 1,123 patients, distributed into four age groups, were analyzed. Of these, 278 were ≥ 64 years old (fourth quartile) and 133 were ≥73 years old (tenth decile). Elderly patients weighed less, were more frequently treatment- ...
Tópico(s): HIV/AIDS drug development and treatment
2018 - Elsevier BV | Annals of Hepatology