Tobias Klein, Rein Jueri Palisaar, Alexander Holz, Marko Brock, Joachim Noldus, Andreas Hinkel,
... Palisaar, Alexander Holz, Marko Brock, Joachim Noldus, and Andreas Hinkel Tobias KleinTobias Klein , Rein Jueri PalisaarRein Jueri Palisaar , ... author Joachim Noldus More articles by this author Andreas Hinkel More articles by this author Expand All Advertisement ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2010 - Lippincott Williams & Wilkins | The Journal of Urology
Christoph Kowalski, Rebecca Roth, Günther Carl, Günter Feick, Alisa Oesterle, Andreas Hinkel, Thomas Steiner, Marko Brock, Björn Theodor Kaftan, R. Borowitz, Niko Zantl, Axel Heidenreich, Andreas Neisius, Christopher Darr, Christian Bolenz, Burkhard Beyer, Jesco Pfitzenmaier, Bernhard Brehmer, Jan Fichtner, Björn Haben, Simone Wesselmann, Sebastian Dieng,
To give an overview of the multicenter Prostate Cancer Outcomes (PCO) study, involving paper-based and web-based collection of patient-reported outcome measures (PROM) in patients undergoing local treatment for prostate cancer in certified centers in Germany. The PCO study is part of the larger Movember-funded TrueNTH Global Registry. The article reports on the study's design and provides a brief progress report after the first 2 years of data collection.Prostate cancer centers (PCCs) certified according ...
Tópico(s): Clinical practice guidelines implementation
2020 - Springer Nature | Journal of Patient-Reported Outcomes
Nora Tabea Sibert, Sebastian Dieng, Alisa Oesterle, Günter Feick, Günther Carl, Thomas Steiner, Jörg Minner, Florian Roghmann, Björn Theodor Kaftan, Friedemann Zengerling, Andreas Hinkel, Burkhard Beyer, Axel Heidenreich, Nina N. Harke, Bernhard Brehmer, Jesco Pfitzenmaier, Jan Fichtner, Andreas Neisius, Peter Hammerer, Simone Wesselmann, Christoph Kowalski,
Tópico(s): Prostate Cancer Treatment and Research
2019 - Springer Science+Business Media | World Journal of Urology
Florian Roghmann, Christian von Bodman, Björn Löppenberg, Andreas Hinkel, Jüri Palisaar, Joachim Noldus,
Study Type – Prognosis (prospective cohort) Level of Evidence 2a What's known on the subject? and What does the study add? Fournier's gangrene (FG) is a rare but life-threatening disease challenging the treating medical staff. Despite the fact that antibiotic therapy combined with surgery and intensive care surveillance are performed as standard treatment, mortality rates remain high. There have been efforts to develop a reliable tool to predict severity of the disease, not only to identify patients ...
Tópico(s): Sepsis Diagnosis and Treatment
2012 - Wiley | BJU International
Jüri Palisaar, Sven Wenske, Florian Sommerer, Andreas Hinkel, Joachim Noldus,
To assess the peri- and postoperative outcome of patients treated with open radical retropubic prostatectomy (RRP) for prostate cancer and who had previously undergone transurethral resection of the prostate (TURP).Prospectively collected data from a consecutive series of 1760 patients who had RRP between July 2003 and June 2007 at our institution were used to retrospectively match 62 cases (with previous TURP) with the same number of controls (without previous TURP). Matching variables were patient ...
Tópico(s): Urologic and reproductive health conditions
2009 - Wiley | BJU International
Michael Nosseir, Andreas Hinkel, Jürgen Pannek,
The vast majority of spinal cord lesions cause neurogenic bladder disorders. Detrusor hyperreflexia presents a major risk factor for renal damage in these patients. We evaluated the long-term results of patients with spinal cord injury treated at our institution.Eighty spinal cord injury patients (60 male, 20 female; mean age 29.6 years) with at least one follow-up visit a year for a minimum of five consecutive years, were included in this retrospective analysis. Follow-up included urodynamic evaluation, ...
Tópico(s): Urological Disorders and Treatments
2006 - Wiley | Neurourology and Urodynamics
Jürgen Pannek, U. Grigoleit, Andreas Hinkel,
To analyze the bacterial contamination of conventional percutaneous nerve stimulation (PNE) leads. Sacral neuromodulation has become an important tool for the treatment of urgency and chronic retention. Patients likely to benefit from this type of therapy are identified by PNE testing before implantation of the definitive system. Recently, a new system was introduced, using a self-blocking electrode that remains in place for both PNE testing and final implantation. PNE testing warrants an extracorporeal ...
Tópico(s): Vagus Nerve Stimulation Research
2005 - Elsevier BV | Urology
Andreas Hinkel, W Finke, U Bötel, Sören Gatermann, J. Pannek,
To investigate changes of the bacterial spectrum and susceptibility in bacteria isolated from urine samples of spinal cord injury patients followed in a strict outpatient setting.Due to neurogenic dysfunction, urinary tract infections are common in spinal cord injury patients. Nosocomial urinary tract infections and resistance against antibiotics are increasing problems in hospitalized spinal cord injury patients. Urine samples were obtained by aseptic catheterization during 1,293 outpatient appointments ...
Tópico(s): Spinal Dysraphism and Malformations
2004 - Karger Publishers | Urologia Internationalis
Barbara J. Gitlitz, Arie S. Belldegrun, Amnon Zisman, Debby H. Chao, Allan J. Pantuck, Andreas Hinkel, Peter F.A. Mulders, Nancy P. Moldawer, Cho-Lea Tso, Robert A. Figlin,
Cultured tumor lysate-loaded dendritic cells (TuLy-DC) have been demonstrated in vitro to stimulate potent immune modulations and generate significant antitumor response. We report the results of a pilot trial of TuLy-DC vaccine for patients with metastatic renal cell carcinoma (mRCC). Fourteen mRCC patients underwent nephrectomy to obtain autologous TuLy prepared by subjecting tumor cells to 3 freeze/thaw cycles. Dendritic cells were generated from peripheral blood CD14+ precursors cultured in the ...
Tópico(s): CAR-T cell therapy research
2003 - Lippincott Williams & Wilkins | Journal of Immunotherapy
Arie S. Belldegrun, Cho-Lea Tso, Amnon Zisman, John Naitoh, Jonathan W. Said, Allan J. Pantuck, Andreas Hinkel, Jean B. deKernion, Robert A. Figlin,
Twenty-four patients with locally advanced prostate cancer (CaP) were enrolled in a phase I clinical trial using gene-based immunotherapy. A functional DNA-lipid complex encoding the interleukin 2 (IL-2) gene (Leuvectin; Vical, San Diego, CA) was administered intraprostatically into the hypoecogenic tumor lesion, using transrectal ultrasound guidance. Two groups of patients having locally advanced tumors were enrolled to receive a treatment regimen composed of two serial intraprostatic injections of ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2001 - Mary Ann Liebert, Inc. | Human Gene Therapy
Andreas Hinkel, Cho-Lea Tso, Barbara J. Gitlitz, Negoita Neagos, Ingrid Schmid, Sun H. Paik, Jean B. deKernion, Robert A. Figlin, Arie S. Belldegrun,
Dendritic cells (DCs) loaded with tumor antigens have the potential to become a powerful tool for clinical cancer treatment. Recently, the authors showed that a tumor-specific immune response can be elicited in culture via stimulation with autologous renal tumor lysate (Tuly)–loaded DCs that were generated from cytokine-cultured adherent peripheral blood mononuclear cells (PBMCs). Here, the authors show that immunomodulatory DCs can be generated directly from nonfractionated bulk PBMC cultures. Kinetic ...
Tópico(s): Immune Cell Function and Interaction
2000 - Lippincott Williams & Wilkins | Journal of Immunotherapy
Peter Mulders, Cho-Lea Tso, Shen Pang, Randhir Kaboo, William H. McBride, Andreas Hinkel, Barbara J. Gitlitz, Jens Dannull, Robert A. Figlin, Arie S. Belldegrun,
Combination therapy with interleukin-2 (IL-2) and tumor-infiltrating lymphocytes (TILs) demonstrates significant clinical activity in patients with metastatic renal cell carcinoma (RCC). To investigate whether local delivery of IL-2 via gene transfer is capable of improving the potency and efficacy of in vitro propagated TILs as compared with standard growth conditions [400 BRMP U (BU)/ml], a replication-deficient adenovirus expressing the human IL-2 gene under control of the cytomegalovirus (CMV) promoter ( ...
Tópico(s): Cancer Research and Treatments
1998 - Lippincott Williams & Wilkins | Journal of Immunotherapy
Ricarda Thier, Frederike Wiebel, Andreas Hinkel, A. Bürger, Thomas Brüning, K Morgenroth, Theodor Senge, Michael Wilhelm, Thomas Schulz,
Tópico(s): Genomics, phytochemicals, and oxidative stress
1998 - Springer Science+Business Media | Archives of Toxicology
Andreas Hinkel, R. Berges, Jürgen Pannek, Harald Schulze, Th. Senge,
Cyproterone acetate (CPA) was the first steroidal antiandrogen used for the treatment of prostatic cancer. In recent studies CPA has been linked with DNA adduct formation and increased DNA repair synthesis in vitro, suggesting an increased risk for the development of hepatic malignancies. To assess liver-toxic and carcinogenic effects, 89 patients who received CPA 50 mg/day p.o. over 4 (range 2-152 months) years for prostatic cancer treatment were retrospectively evaluated. 22 patients (28.2%) showed ...
Tópico(s): Cancer, Lipids, and Metabolism
1996 - Elsevier BV | European Urology
Matteo Roggero, Sergio Villamayor‐Tomás, Christoph Oberlack, Klaus Eisenack, Alexander Bisaro, Jochen Hinkel, Andreas Thiel,
Abstract This article introduces the special issue on climate adaptation and institutions. Economic accounts of climate adaptation have stressed its collective action nature and the limitations of standard economic approaches to the matter. Governance accounts, on their part, have shown that adaptation does not always happen when it is expected. Against this background, institutional economics has the potential to shed light on those societal processes and collective mechanisms leading to and shaping ...
Tópico(s): Sustainability and Climate Change Governance
2018 - Cambridge University Press | Journal of Institutional Economics
Andreas Hinkel, Sonja Schmidtchen, Rein‐Jueri Palisaar, Joachim Noldus, Jürgen Pannek,
Despite similarities in tumor stage and grade the individual outcome of bladder cancer patients is not predictable. The ideal tool for treatment stratification has not yet been found. Metallothionein (MT) overexpression is correlated with poor tumor differentiation, resistance to chemotherapy, and impaired survival in different malignancies. The clinical relevance of MT expression for defining patients at high risk for recurrence or progression was assessed. MT was detected immunohistochemically ...
Tópico(s): Bone and Dental Protein Studies
2008 - Taylor & Francis | Journal of Toxicology and Environmental Health
Rebecca Roth, Sebastian Dieng, Alisa Oesterle, Günter Feick, Günther Carl, Andreas Hinkel, Thomas Steiner, Björn Theodor Kaftan, Frank Kunath, Boris Hadaschik, Simba‐Joshua Oostdam, Rein Jüri Palisaar, Mateusz Koralewski, Burkhard Beyer, Björn Haben, Igor Tsaur, Simone Wesselmann, Christoph Kowalski,
Abstract Purpose The self-reported functional status (sr-FS) of prostate cancer (PCa) patients varies substantially between patients and health-care providers before treatment. Information about this issue is important for evaluating comparisons between health-care providers and to assist in treatment decision-making. There have been few reports on correlates of pretherapeutic sr-FS. The objective of the article, therefore, is to describe clinical and sociodemographic correlates of pretherapeutic ...
Tópico(s): Cancer survivorship and care
2020 - Springer Science+Business Media | World Journal of Urology
Tobias Klein, Sebastian Rotterdam, Joachim Noldus, Andreas Hinkel,
Renal cell carcinoma is associated with paraneoplastic syndromes in up to 40% of cases. Dermatological manifestations are rare. A case of a bullous pemphigoid as a paraneoplastic symptom was diagnosed in a 52-year-old patient with a partially sarcomatoid papillary renal cell carcinoma.
Tópico(s): Dermatological and Skeletal Disorders
2009 - Taylor & Francis | Scandinavian Journal of Urology and Nephrology
Andreas Hinkel, Jürgen Pannek,
Abstract Electromotive drug administration (EMDA) is a new and promising approach for the treatment of chronic non‐infectious cystitis. In animal studies utilizing EMDA there was evidence for deep penetration of dyes into the muscular layers of the bladder wall. However, besides minor local irritation no systemic side effects have been reported after translation of EMDA into the clinical setting. Aims This article reports for the first time systemic neurological alterations after EMDA for chronic ...
Tópico(s): Poisoning and overdose treatments
2004 - Wiley | Neurourology and Urodynamics
S. Hinkel, Kai Mattern, Andreas Dietzel, Stephan Reichl, Christel C. Müller‐Goymann,
In brain research, the hCMEC/D3 cell line is widely used for the establishment of a human in vitro blood-brain barrier (BBB) model. However, its barrier integrity seems to be insufficient for drug permeability studies, represented by rather low transendothelial electrical resistance (TEER) and high permeability of small molecules. Therefore, this study covers a parametric investigation of static and dynamic cell culture conditions to improve barrier functionality of hCMEC/D3. The effect of basal media ...
Tópico(s): Drug Transport and Resistance Mechanisms
2019 - Elsevier BV | International Journal of Pharmaceutics
Tobias Klein, Alexander Holz, Matthias Neid, Andreas Hinkel, Joachim Noldus,
Causes for acquired unilateral obstruction of the ureter are numerous: calculi, infections, blood clots and tumors are the most common underlying pathologies. Hematologic tumors with initial clinical manifestation in the lower urinary tract are rare. Primary localization of plasmocytoma has been described in kidney, bladder and urethra. Herein, we describe the first manifestation of a primary solitary extramedullary plasmacytoma of the ureter. The tumor was discovered upon diagnostic workup of gross ...
Tópico(s): Complement system in diseases
2010 - Karger Publishers | Urologia Internationalis
Jean‐Pierre Gattuso, Alexandre Magnan, Laurent Bopp, William W. L. Cheung, Carlos M. Duarte, Jochen Hinkel, Elizabeth Mcleod, Fiorenza Micheli, Andreas Oschlies, Phillip Williamson, Raphaël Billé, Vasiliki Ι. Chalastani, Ruth D. Gates, Jean‐Olivier Irisson, Jack J. Middelburg, Hans‐Otto Pörtner, Greg H. Rau,
The Paris agreement target of limiting global surface warming to 1.5-2°C compared to pre-industrial levels by 2100 will heavily impact the ocean. While ambitious mitigation and adaptation are both needed, the ocean provides major opportunities for action to reduce climate change globally and its impacts on vital ecosystems and ecosystem services. A comprehensive and systematic assessment of 13 global- and local-scale, ocean-based measures was performed to help steer the development and implementation ...
Tópico(s): Marine and fisheries research
2018 - Frontiers Media | Frontiers in Marine Science
Florian Roghmann, von Bodman C, Zhongxiang Tian, Marko Brock, Björn Löppenberg, Katharina Braun, Andreas Hinkel, Jüri Palisaar, Joachim Noldus,
Tópico(s): Antimicrobial Resistance in Staphylococcus
2013 - Springer Nature | Der Urologe
Nora Tabea Sibert, Tobias Kurth, Clara Breidenbach, Simone Wesselmann, Günther Feick, Ernst-Günter Carl, Sebastian Dieng, Mohamad Hatem Albarghouth, Atiqullah Aziz, Stefan Baltes, Elisabeth Bartolf, Jens Bedke, Andreas Blana, Marko Brock, Stefan Conrad, Christopher Darr, Florian Distler, Konstantinos Drosos, Gregor Duwe, Amr A. Gaber, Markus Giessing, Nina N. Harke, Axel Heidenreich, Sameh Hijazi, Andreas Hinkel, Björn Theodor Kaftan, Shatlyk Kheiderov, Thomas Knoll, G. Lümmen, Inga Peters, Bülent Polat, Valentin Schrodi, Jens‐Uwe Stolzenburg, Zoltán Varga, Julius von Süßkind-Schwendi, Vahudin Zugor, Christoph Kowalski,
Background Incontinence and sexual dysfunction are long-lasting side effects after surgical treatment (radical prostatectomy, RP) of prostate cancer (PC). For an informed treatment decision, physicians and patients should discuss expected impairments. Therefore, this paper firstly aims to develop and validate prognostic models that predict incontinence and sexual function of PC patients one year after RP and secondly to provide an online decision making tool. Methods Observational cohorts of PC patients ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2023 - Public Library of Science | PLoS ONE
Andreas Hinkel, Werner de Riese, J. Alefelder, Dominik Laumann, F. W. Falkenberg, Th. Senge, L. Hertle,
Tópico(s): Cancer Genomics and Diagnostics
1995 - Elsevier BV | European Journal of Cancer
Andreas Thiel, Christian Schleyer, Jochen Hinkel, Maja Schlüter, Konrad Hagedorn, Alexander Bisaro, Ihtiyor Bobojonov, Ahmad Hamidov,
Institutional fit is operationalized by transferring transaction costs economics (TCE) to the analysis of instances of social-ecological interdependence. We carefully spell out the differences with conventional TCE and outline analytical steps based on discriminating alignment that enable a TCE analysis of environmental governance of "nature-related transactions". We illustrate the approach through the example of wildlife management in Germany. Here we find hierarchical governance (a prohibition) of ...
Tópico(s): Forest Management and Policy
2016 - Elsevier BV | Ecological Economics
Hilmar Reiß, Lei Ji, Jie Han, Silke Koser, Olena Tverskoy, Jan Freudenberg, Felix Hinkel, Michael Moos, Alexandra Friedrich, Ivo Krummenacher, Christoph Lambert, Holger Braunschweig, Andreas Dreuw, Todd B. Marder, Uwe H. F. Bunz,
Abstract Ein TIPS‐ethinyl‐substituiertes Diamin wurde mit in situ erhaltenem 4,5‐Dibrom‐ortho‐chinon in einer Cyclokondensation zu Tetrabromtetraazapentacen (BrTAP) umgesetzt. BrTAP ist leicht zu seinem luftstabilen kristallinen Radikalanion zu reduzieren; in Dünnschichttransistoren erreicht BrTAP Elektronenbeweglichkeiten von >0.56 cm 2 V −1 s −1 .
Tópico(s): Magnetism in coordination complexes
2018 - Wiley | Angewandte Chemie
Hilmar Reiß, Lei Ji, Jie Han, Silke Koser, Olena Tverskoy, Jan Freudenberg, Felix Hinkel, Michael Moos, Alexandra Friedrich, Ivo Krummenacher, Christoph Lambert, Holger Braunschweig, Andreas Dreuw, Todd B. Marder, Uwe H. F. Bunz,
A cyclocondensation of TIPS-ethynyl-substituted diaminoarenes with in situ obtained 4,5-dibromocyclohexa-3,5-diene-1,2-dione has led to the synthesis of tetrabromotetraazapentacene (BrTAP). BrTAP is easily reduced to its air-stable radical anion and electron mobilities >0.56 cm2 V-1 s-1 can be achieved in thin-film transistors.
Tópico(s): Luminescence and Fluorescent Materials
2018 - Wiley | Angewandte Chemie International Edition
Tobias Klein, Alexander Holz, Andreas Hinkel, Joachim Noldus,
... A PROSPECTIVE PILOT STUDY Tobias Klein, Alexander Holz, Andreas Hinkel, and Joachim Noldus Tobias KleinTobias Klein More articles ... author Alexander Holz More articles by this author Andreas Hinkel More articles by this author Joachim Noldus More ...
Tópico(s): Anesthesia and Pain Management
2010 - Lippincott Williams & Wilkins | The Journal of Urology
Andreas Hinkel, Dirk Strumberg, Joachim Noldus, Jürgen Pannek,
We diagnosed de novo bladder dysfunction in several breast cancer patients under cancer-specific therapy with trastuzumab. The goal of this retrospective analysis was to investigate whether bladder dysfunction is common in a larger population of breast cancer patients receiving trastuzumab therapy.We identified 93 patients who received at least two doses of trastuzumab at our institution in the years 2003-2006. 57 of those patients were still alive at the time of this analysis. We mailed a validated ...
Tópico(s): Esophageal Cancer Research and Treatment
2010 - Karger Publishers | Urologia Internationalis