Jonathan Northcroft, Tracey Boles, John Dugdale, Hala Jaber, William Kay, John Sillers, Matthew Wall, Barbara Hall, Bill Gleave Chairman, Jim Munro, Jon Swain, Dominic Sandbrook, Günter Grass, Sally Brock, Helen Davies, Nicholas Rufford, Rob Hughes, Ian Wylie, Mariusz Lodkowski, Peter Whittle, F Parker, E Young, John Waples Business Editor, L Todd, Liz Hancock, Frank Whitford, Jenny Dalton, Ivo Tennant, Dr Raphael Ehan, Paul Hornby, Justine Roberts, David Smith, Mike Birarritz, Duncan Bannatyne, Neil Wormald, Peter Cosco, Mark Hughes, Andrew Sullivan, E P, Brian Saffer, Clive Davis, Trevor Allanson, K R, Adam Abdelnoor Cheif Executive, Nick Leslie, C D, Steve Barnes, Martin Jol, Paul Jewell, Tony Allen-Mills, Simon Wilde, William Hague, D C, Martin James, Ariel Leve, Andrew Franked, Robert Winnett, Andrew Clover, Sir Alex Ferguson, Irwin Stelzer, Peter Wilson, Rosie Millard, David Dougill, Arsene Wenger, D R, Peter Barron Editor, Christopher Hart, Colin Taylor, Wayne Rooney, Nick Savage, Geraldine Hackett, Paul Flynn, H C, Rob Maul, Alistair Weaver, Lynda Hopkins, Paul Forsyth, Hugh Canning, Isabel Oakeshott, Glenn Roeder, Jeremy Clarkson, David Cairns, John Topley, Edward Porter, Elizabeth Shepherd, Claire Newell, Michael Portillo, Julian Grenfell, Renny Snell, Giles Chapman, S L, Patricia Nicol, Sarah Dempster, Adrian Turpin, Brian Cox, Dave Pollard, Peter Logan, Kathy Shuttleworth, Anita Chaudhuri, Richard Fletcher, Sylvia Downing, Dominic Connell, Rafael Benitez, Jeremy Taylor, Jeff Potter, Sarah-Kate Templeton Health Correspondent, Paul Bailey, Jason Dack, Jenni Murray, Max Hastings, Michael Waugh, Paul Ham, Stuart Wavell, Christopher Silvester, Harry Redknapp, John Stobie, Angela Newing, Leo Sayer, Paul Kimmage, Giles Hattersley, Chris Woodhead, Monsieur Mangetout, Roy Richardson, Phill Spencer, Paul Driver, Derek Clements, Miami Vice, John Follain, Richard Brooks, Hyman Mintz, Arthur Lee, Ian Hawkey, Lord March, Stuart Andrews, Caroline Scott, David Leppard, Shelley Von Strunckel, Surinder Bassi, Mark Edwards, Heston Blumenthal, Trevor Hamley, Chris Coleman, Stephen Clarke, Ken Scants, Christina Lamb, Neil Warnock, Ross Lee, Raymond Keene, C L, Cliff Wilton, Rod Liddle, Lawrence Booth, Penelope Lively, Robbie Hudson, Ifor R Griffiths, Kipper Williams, David Moyes, Emma Smith, Stephen Jones, Dominic O'Connell, Stephen Bleach, Louise Armitstead, Uzi Mahnaimi, Mary Lobo, Nick Cain, Steve Coppell, Alan Pardew, Michael Wright, Jose Mourinho, James Dyson, Susan Kelly, Simon Burton, Caroline Donald, D Hall, Simon Baylik, Philip Sen, S A, Stuart Pearce, Rowan Williams, Trevor Lewis, Gareth Southgate, Caroline Branningan, David Gunn, S P, Colin McDowell, Stephen Armstrong, Adrian Boothroyd, John Elliott, Anna Mikhailova, Isabel Oakeshott Deputy Political Editor, Russell Miller, Bethan Cole, Antony Sattin, Lauren Howey, Roland White, N R, Steven Swinford, Alison Jane Reid, J Higgins, Abul Taher, J M Pinney, Rachel Johnson, Maurice Chittenden, Vincent Marcello, Mark Watts, Alastair McKay, Virginia Rounding, Mark Franchetti, Jon Ungoed-Thomas, Mike Brewer, Andrew Rogers, John Penman, M E, Sam Allardyce, Clare Francis, Michael Smith, John Harlow, Patrick Grant, Martin O'Neill, Fiona Bruce, Chris Haslam, Dipesh Gadher, Tom Baird, Mark Kleinman, Sarah Anderson, John Waples, Navid Akhtar, Mary Davies, Harry Arnold, A A Gill, David Parsons, Hunter Davies, Matthew Campbell, Brian Glanville, Daniel Foggo, Tom Steer, Martin Wroe, Dainel Emery, Soph Gill, W Pope, Margo Stilley, Simon Jenkins, Stephen Pettitt, Andrew Lycett, Claudia Croft, Jessica Bown, Olivia Cole, T L, Ciaran Hancock, R H, Sally Kinnes, Hollie Smith, Chris Morris, Roger Cooper, Clarence Barrett, Roger Dobson, Peter Almond, Kevin Baker Warrant Officer, Brian Doogan, John Aizlewood, Minette Marrin, Iain Dowie, J P, James Scoltock, Gordon Christian, Ken Lunn, Joe Lovejoy, Graham Norwood, Andrew Frankel, P W, David Budworth, Hugh Pearman, E U, Andrew Davidson, Dan Cairns, David Grylls, Katy Duke, Tony Balding, David Smith Economics Editor, Tom Deveson, R U, Sarah Baxter, Joanna Simon, Matthew Goodman, India Knight, Kate Spicer, Jason Dawe, Richard Lewis, Sian Griffiths, Helen Stewart,
... Reading Sheffield Utd West Ham Tottenham Watford Wigan Andriy Shevchenko The top 10 Premiership new boys … Zokora The ...
2006 - Gale Group | Sunday Times HA GDA
Carsten Janke, Jennifer Ortiz, Johannes Lechner, Andriy Shevchenko, Andriy Shevchenko, Maria M. Magiera, Carolin Schramm, Elmar Schiebel,
Here, we show that the budding yeast proteins Ndc80p, Nuf2p, Spc24p and Spc25p interact at the kinetochore. Consistently, Ndc80p, Nuf2p, Spc24p and Spc25p associate with centromere DNA in chromatin immunoprecipitation experiments, and SPC24 interacts genetically with MCM21 encoding a kinetochore component. Moreover, although conditional lethal spc24-2 and spc25-7 cells form a mitotic spindle, the kinetochores remain in the mother cell body and fail to segregate the chromosomes. Despite this defect ...
Tópico(s): Chromosomal and Genetic Variations
2001 - Springer Nature | The EMBO Journal
Peter Wakefield, Richard Clayton, Waldemar Januszczak, Roy Keane, John Dugdale, Anna Walters, William Kay, Patrick French, Barbara Hall, Cameron Diaz, Matthew Wall, Nigel Botherway, Andrew Gimson, Lesley Lass, N J, Jim Munro, Sally Brock, Helen Davies, Peter Whittle, Ricky Gervais, Rob Hughes, Dr G L Roberts, Daisy Waugh, D G, J K, John Peter, David Lowe, Tim Dawson, Martyn Blacknell, P Kennedy, Michael Richards, Andrew Longmore, John Waples Business Editor, Susan d'Arcy, Dipesh Shah, Sally Brampton Advises, Neil Struthers, Frank Whitford, Peter Thomas, Kathryn Tope, Amal Basu, Matthew Davis, Rosie Milliard, Jon Kirk, Kathryn Cooper, Alex Wade, Jeremy Lazell, David Smith, Ian Pocock, Nick Pitt, Neil Wormald, Richard Green, Clive Davis, Kathy Brewis, Tony Allen-Mills, Martin James, John Dugdate, Gemma Scott-Martin, Ariel Leve, Robert Winnett, Margareta Pagano, Chris Anderson, Adrian Furnham, Matt Rudd, Peter Wilson, Neil Wormaid, David Dougill, John Arlidge, Robert Jackson, Desmond Tutu, Ron Brotherhood, Lucy Denyer, Christopher Hart, Stuart Barnes, Atul Kochhar, Major Philip Sturtivant, Stephen Venables, Paul Forsyth, Hugh Canning, Isabel Oakeshott, Alan McKechnie, Jeremy Clarkson, James Murray Wells, John Nasmith, Phil Spencer, Stewart Lee, Peter Kemp, Victoria Segal, Michael Portillo, Edward Porter, Valerie Bridgman, M P, Christian Brook, Sarah Dempster, Katharine Houreld, Charles Jackson, Alan Dorling, Pete Downing, Peter Millar, Greg Struthers, Alan Johnson, Simon Harding, Jo Nicol-Simpson, Dr Michael Powers Qc, Jeff Potter, Sarah-Kate Templeton Health Correspondent, Paul Bailey, Holly Watt, Daisy Goodwin, Pat Malone, Colin Thubron, Max Hastings, Peter Parker, Dg, Roger Eglin, Paul Donovan, Michael Sherdian, Robert K Large, Barry Unsworth, Robert Howison, John Stepek, Michael Saxby, Kenny Farqharson, Tom Stubbs, Paul Kimmage, Giles Hattersley, Hugh McIlvanney, Chris Woodhead, Jasper Gerard, Paul Driver, Simon Goodley, Ian Hawkey, Joe Lovejoy football correspondent, Jonathan Grant-Nicholas, Christopher Morgan, David Leppard, Tarquin Hall, Paul Durman, Shelley Von Strunckel, Walter Grey, Mark Edwards, Robert Hughes, Rachel Bridge, Shirley Lowe, J Davies, Tom Baker, S M, Karen Gold, Robert Booth, Raymond Keene, Peter Iden, Rod Liddle, Kit Johnson, Vic Gamble, David Cracknell, Douglas Alexander, Lawrence Booth, Richard Fleming, Marion Welham, Cosmo Landesman, Diana Wright, Robbie Hudson, Christopher Gibbins, Jay Leno, Helen Hawkins, Rebecca Tanqueray, David Hockney, Roy Roebuck, Stephen Jones, Dominic O'Connell, Barry Flatman, Nick Cain, Louise Armitstead, Stephen Bleach, Mildenhall, Andrew Holgate, John Francis La Gure, Clive Aslet, Caroline Donald, Matt Cope, Rob Ryan, Barbara Coultas, Ian Andrew Walker, Helen Brown, Dennis Greenan, Tiffanie Darke, Colin McDowell, Jennifer Moore, Bryan Appleyard, Ant Donaldson, Stephen Armstrong, John Elliott, Isabel Oakeshott Deputy Political Editor, Mark Stucklin, Julian Clary, Bethan Cole, Grant Ringshaw, Richard Woods, Roland White, Chris Haslem, Steven Swinford, Shane Watson, Abul Taher, Maurice Chittenden, Richard Brooks Arts Editor, Judith O'Reilly, Mark Franchetti, Jon Ungoed-Thomas, Louise Armistead, Rupert Smith, Sarah Demspter, M E, Lucy Ewing, John Crossland, Clare Francis, Michael Smith, John Harlow, Rodney Pattison, Chris Haslam, Leonard Shapiro, John Waples, Gareth Jenkins, Paul Rowan, Roger Waite, Paul Forstyth, Alex Pell, Denis Walsh, A A Gill, Rt Hon William Hague Shadow Foreign Sretary, Stephen Jones Rugby Correspondent, Mary Braid, Simon Jenkins, Stephen Pettitt, Deirdre Fernand, Claudia Croft, Jessica Bown, Olivia Cole, Jonathan Leake Science Editor, Jonathan Calvert, Joe Ledley, Ed Grenby, Jonathan Milne, Sally Kinnes, David Wickers, Roger Dobson, John Aizlewood, Minette Marrin, John Cornwell, Andrew Mitchell Mp, Scott Colvin, Andrew Frankel, Patrick Hulls, Graham Norwood, Joe Lovejoy, Victor Bryant, A P, David Budworth, Dan Cairns, Sylvia Cowling, David Smith Economics Editor, Diana Furchtgott-Roth, Jimmy Hill, Sarah Baxter, Pat Sitch, Emma Sanchez, Chris Feetenby, Jonathan Miline, Matthew Goodman, India Knight, Fleur Britten, Sara Hassan, Louise Hughes, David Taine, Ed Hughes, Simon Howard, Jason Dawe, Dominic Rushe, David Thomson, Sian Griffiths, Karen Robinson, Dorset, Helen Stewart,
... with my own merits and weaknesses' Chelsea striker Andriy Shevchenko says he still has much to prove, starting ...
2006 - Gale Group | Sunday Times HA GDA
Wenying Shou, Jae Hong Seol, Andriy Shevchenko, Christopher Baskerville, Danesh Moazed, Z.W.Susan Chen, Joanne Jang, Andriy Shevchenko, Harry Charbonneau, Raymond J. Deshaies,
Exit from mitosis in budding yeast requires a group of essential proteins—including the GTPase Tem1 and the protein phosphatase Cdc14—that downregulate cyclin-dependent kinase activity. We identified a mutation, net1-1, that bypasses the lethality of tem1Δ. NET1 encodes a novel protein, and mass spectrometric analysis reveals that it is a key component of a multifunctional complex, denoted RENT (for re gulator of n ucleolar silencing and t elophase), that also contains Cdc14 and the silencing regulator ...
Tópico(s): Plant nutrient uptake and metabolism
1999 - Cell Press | Cell
Andrew Robson, Ken Sussell, Amanda Andrews, Peter Kllnger, Robert Cole, Bel Mooney, Andrew Pierce, Reggie Lawson-Tims, Gary Duncan, Pascal Salin Professor, Devika Bhat, Philip Moor, Andrew Moylan, Valentine Le Grice, Professor Rebecca Bailey-Harris, Christine Seib, David Chater, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Sam Coates Political Correspondent and Sara McCorquodale, Rosalind Renshaw, Gabrielle Starkey, Carl Mortished, Will Pavia, Amanda Andrews Media Business Correspondent, Sam Marlowe, Geoff Brown, Joe Joseph, David Sharrock, Bronwen Maddox Editors, Stewart Tendler Crime Correspondent, Tom Bawden, Shirley English, Peter Lanstey, Andrew Norfolk and Frences Gibb, Jill Dupleix, Richard Lynn Professor, Dean Godson, Mike Harding, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Stephen Farrell, Nigel Hawkes and Anjana Ahuja, Valerie Elliott Consumer Editor, Richard Lloyd Parry, Paul Sinclair, Dr. E. H. Brooks, Graham Keeley, Matt Dickinson Chief Football Correspondent, Robert Smith, Angela Jameson, Gary Duncan Economics Editor, Oliver Kay, Neil Harman, Rick Broadbent, Tom Baldwin, Sam Coates, John Hopkins Golf Correspondent, Xabi Alonso, Alice Olins, Gabriel Rozenberg, Bernard Lagan, Martin Samuel, Matt Hughes, Sean O'Neill, Rosemary Bennett Deputy Political Editor, Martin Griffies, Jeremy Page, Caroline Merrell, Chris Campling, Fran Yeoman, Patrick Hosking, Richard Owen, Charlotte Mullins, Tim Pope, Nick Hasell, Katle Scott, Grayson Perry, David Hands Rugby Correspondent, Patrick kidd, Paul Simons, Anne Ashworth, James Doran, Craig Lord, Ian Johns, Charles Bremner and Marie Tourres, Barry M. Marsden, Anjana Ahuja, George Caulkin, Professor Ian K. Smith, Alan Lee, Tim Martin, Peter Riddell, Michael Gove, Aníbal De Castro, Peter Jenson, Michael Hayes, Martin Waller, Alexandra Blair Education Correspondent and Ian Evan, Alan Coren, Nigel Hawkes Health Editor, Sarah Butler, Benedict Nightingale, Oliver Kamm, Dr Thomas Stuttaford, Stephen Dalton, Ben Hoyle, Nicola Woolcock, Richard Morrison, Philip Webster and Rosemary Bennett, Alice Miles, Adam Sherwin, Adam Fresco and Bernard Lagan, Alan Lee Racing Correspondent, Susan Deal, Sam Lister Health Correspondent, Nick Meo,
... s Results Late goals from Filippo Inzaghi and Andriy Shevchenko … Arsenal's great expectations in Europe could result ...
2006 - Gale Group | TDA
Andriy Shevchenko, Ole N. Jensen, Alexandre V. Podtelejnikov, Francis Sagliocco, Matthias Wilm, Ole Vorm, Peter Mortensen, Andriy Shevchenko, Hélian Boucherie, Matthias Mann,
The function of many of the uncharacterized open reading frames discovered by genomic sequencing can be determined at the level of expressed gene products, the proteome. However, identifying the cognate gene from minute amounts of protein has been one of the major problems in molecular biology. Using yeast as an example, we demonstrate here that mass spectrometric protein identification is a general solution to this problem given a completely sequenced genome. As a first screen, our strategy uses ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
1996 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Giles Smith, Andrew Robson, Nigel Kendall and Stuart Miles, Tom Foster, DJM, Neelam Verjee, Tim Albone, Zahid Hussain, Harry Potter, David Aaronovitch, Georgina Vallance-Webb, Alexandra Blair, James Doran and Martin Waller, Richard Hobson, Simon Ramsden, Sir Alan Moses, Ivo Tennant, Denys Franzini, Philip Howard, David Pannick, Christine Seib, David Chater, James Bone, James Ducker, Rachel Campbell-Johnston, Elizabeth Judge, Richard Irving, Mark Griffiths Horticulture Correspondent, Gabrielle Starkey, Carl Mortished, Patrick Kidd, Amanda Andrews Media Business Correspondent, Sam Marlowe, Richard Hamilton, John McKeown, Roderick A. Smith Professor, Sven-Goran Friksson, Geoff Brown, Sam Lister, Joe Joseph, Alastair Campbell, Ben Webster Transport Correspondent, Valerie Elliott Countryside Editor, Paul Gascoigne, Lady McCartney, Jack Malvern, Dominic Walsh, Ruth Gledhill, Dan Sabbagh Media Editor, Tom Bawden, Athalie Matthews, Gary Jacob, Tim Reid, Dan Sabbagh, Jane Clarke, Libby Purves, James Badenoch, David Hands, Graham Keeley, Adam Sherwin Media Correspondent, Ben MacHell, Matt Dickinson Chief Football Correspondent, Stefanie Marsh, Claire Sanders, Paul Owen, Lisa Armstrong Fashion Editor, Hugo Rifkind, Angela Jameson, Jean Kaye, Edward Fennell, Gary Duncan Economics Editor, Mark Henderson Science Editor, Rick Broadbent, Morgan Falconer, Andrew Salmon, Gary Slapper, Stephen Jakob, Steuart & Francis, Simon de Bruxelles, Rob Wright, Ann Treneman Parliamentary Sketch, David Powell Athletics Correspondent, Martin Samuel, Raymond Keene, Matthew Pryor, Chris Partridge, Kaveh Solhekol, Heather Brooke, Michael Morpurgo, Caroline Merrell, Chris Campling, Bronwen Maddox, Patrick Hosking, Peter Riddell and Philip Webster, Alan Mak, Jon Robins, Sean O'Neil, John A. Evans, Sarah Greer, Peter Dixon, Nick Hasell, Jonathan Bland, Edward Lister and Stephen Greenhalgh, Dr Alistair J. Sinclair, David Hands Rugby Correspondent, Tom Dart, Julian Muscat, Neil Jones, Paul Simons, Charlie Potter, Peter Dickinson, John Goodbody, Amrit Dhillon, Danny Lee, Rachel Green, Ian Johns, Thomas Shields, George Caulkin, Russell Jenkins, Neil Williams, Peter Riddell, Karen Powell-Williams, Richard Fox, Carly Chynoweth, Richard Beeston Diplomatic Editor, Rajeev Syal, Arthur Bell, Graham Searjeant, David Sinclair, Greg Hurst and Ned Parker and Michael Evans, Martin Waller, Chris Ayres, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Sarah Butler, Stephen Cragg, Dr Thomas Stuttaford, Stephen Dalton, Ben Hoyle, Leo Lewis, David Powell, Anthony Browne Europe Correspondent, Gillian Hay, Frances Gibb, Dan Tench, Dr G. D. Patel, Michael Moore, Stephen Abbott Honorary Secretary, Alexandra Blair Education Correspondent, Olav Bjortomt, Jenny Davey, Edward Gorman Sailing Correspondent, Nicola Copping, Chloe Fordham, Richard Ford, Ross Anderson, Sam Lister Health Correspondent, Christopher Irvine, Stephen Pollard,
... 23,296 Johnson joins Dowie on way out Andriy Shevchenko will decide on his future on Thursday … Alastair ...
2006 - Gale Group | TDA
Sanjay Kumar, Hae Yong Yoo, Akiko Kumagai, Anna Shevchenko, Andriy Shevchenko, William G. Dunphy,
TopBP1 is critical for both DNA replication and checkpoint regulation in vertebrate cells. In this study, we have identified Rif1 as a binding partner of TopBP1 in Xenopus egg extracts. In addition, Rif1 also interacts with both ATM and the Mre11-Rad50-Nbs1 (MRN) complex, which are key regulators of checkpoint responses to double-stranded DNA breaks (DSBs). Depletion of Rif1 from egg extracts compromises the activation of Chk1 in response to DSBs but not stalled replication forks. Removal of Rif1 ...
Tópico(s): Genomics and Chromatin Dynamics
2012 - Taylor & Francis | Cell Cycle
Giles Smith, Andrew Robson, Hazel Blears, MP, Amanda Andrews, Gabriele Marcotti, Robert Cole, Bel Mooney, DJM, Stephen Farrell and Ian MacKinnon, Sarah Potter, Frances Gibb Legal Editor, Gary Duncan, Frances Gibb and Richard Ford, Simon Barnes, Magnus Linklater, Paul Hoggart, Ivo Tennant, Tom Baldwin and Ned Parker, Michael Evans Defence Editor, Philip Howard, Katie Scott, Carol Midgley, Helen Kaut, Shaka Hislop, David Lister Scotland Correspondent, Barbara Barker, Christine Seib, James Bone, James Ducker, Alexandra Frean Social Affairs Correspondent, Bronwen Maddox Foreign Editor, Rosalind Renshaw, Carl Mortished, Richard Lioyd Parry, Sam Marlowe, Lucy Bannerman, David Lindsay, Neil Howlett, Joe Joseph, David McVay, Valerie Elliott, Adrian Smith, Gabby Logan, Gary Jacob, Chris Lebert, Norman Harris, Jill Dupleix, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Dan Sabbagh, Alan Hamilton, David Sharrock Ireland Correspondent, Anthony Browne Brussels Correspondent, Matthew Collings, Matt Dickinson Chief Football Correspondent, Liz Chong, David Charter, Jeremy Plester, Hugo Rifkind, Angela Jameson, Danny Kelly, Douglas Henderson, Gary Duncan Economics Editor, Oliver Kay, Trevor Pateman, Lisa Armstrong, John Westerby, Neil Harman, Rick Broadbent, Patrick Hosking Investment Editor, Phil Redmond Chairman, John Hopkins, John Hopkins Golf Correspondent, Rob Wright, Gordon S. P. Cardew, Ann Treneman Parliamentary Sketch, Matthew Hickford, Raymond Keene, Richard Hobson One-day Cricket Correspondent, Peter Riddell Political Briefing, Matt Dickinson, Matt Hughes, Jonathan Wilton, Kaveh Solhekol, Nigel Hawkes, John Hayward, Caroline Merrell, Fran Yeoman, Rosemary Bennett and Anthony Browne, Jill Sherman, Christopher Martin-Jenkins Chief Cricket Correspondent, Sean O'neill, Nick Hasell, Grayson Perry, David Hands Rugby Correspondent, Adam Fresco, Anne Ashworth, Nell Harman Tennis Correspondent, Glen Hodgson, Philip Webster Political Editor, Catherine Philp and Ned Parker, Ian Johns, Dominic Maxwell, Russell Jenkins, Neil Fisher, Justina Ly, Michael Gove, Grant Lewis, Brian Glanville, David Charter Chief Political Correspondent, Jacqui Goddard, David Sinclair, Martin Waller, James Jackson, Carl Mortished International Business Editor, Danny Baker, Nigel Hawkes Health Editor, Oliver Kamm, Lydia Hislop, Stephen Dalton, Leo Lewis, Bill Edgar, Alice Miles, Alan Lee Racing Correspondent, Pete Williams, Owen Slot, Olav Bjortomt, Keith Farman, Jenny Davey, Richard Ford, Michael Brown, Peter Klinger, Sam Lister Health Correspondent, Joe Bolger, Eye Thomas,
... Day The Teams The Goals Their Finest Hour Andriy Shevchenko knows who should be called heroes, says Gabriele ...
2006 - Gale Group | TDA
Akiko Kumagai, Anna Shevchenko, Andriy Shevchenko, William G. Dunphy,
Treslin, a TopBP1-interacting protein, is necessary for deoxyribonucleic acid (DNA) replication in vertebrates. Association between Treslin and TopBP1 requires cyclin-dependent kinase (Cdk) activity in Xenopus laevis egg extracts. We investigated the mechanism and functional importance of Cdk for this interaction using both X. laevis egg extracts and human cells. We found that Treslin also associated with TopBP1 in a Cdk-regulated manner in human cells and that Treslin was phosphorylated within a ...
Tópico(s): Mitochondrial Function and Pathology
2011 - Rockefeller University Press | The Journal of Cell Biology
Hae Yong Yoo, Akiko Kumagai, Anna Shevchenko, Andriy Shevchenko, William G. Dunphy,
The activation of ATR-ATRIP in response to double-stranded DNA breaks (DSBs) depends upon ATM in human cells and Xenopus egg extracts. One important aspect of this dependency involves regulation of TopBP1 by ATM. In Xenopus egg extracts, ATM associates with TopBP1 and thereupon phosphorylates it on S1131. This phosphorylation enhances the capacity of TopBP1 to activate the ATR-ATRIP complex. We show that TopBP1 also interacts with the Mre11-Rad50-Nbs1 (MRN) complex in egg extracts in a checkpoint- ...
Tópico(s): Microtubule and mitosis dynamics
2009 - American Society for Cell Biology | Molecular Biology of the Cell
Yue Liu, Anna Shevchenko, Andriy Shevchenko, Arnold Berk,
Results reported here indicate that adenovirus 5 exploits the cellular aggresome response to accelerate inactivation of MRE11-RAD50-NBS1 (MRN) complexes that otherwise inhibit viral DNA replication and packaging. Aggresomes are cytoplasmic inclusion bodies, observed in many degenerative diseases, that are formed from aggregated proteins by dynein-dependent retrograde transport on microtubules to the microtubule organizing center. Viral E1B-55K protein forms aggresomes that sequester p53 and MRN in ...
Tópico(s): Nuclear Structure and Function
2005 - American Society for Microbiology | Journal of Virology
Hae Yong Yoo, Anna Shevchenko, Andriy Shevchenko, William G. Dunphy,
In vertebrates, ATM and ATR are critical regulators of checkpoint responses to damaged and incompletely replicated DNA. These checkpoint responses involve the activation of signaling pathways that inhibit the replication of chromosomes with DNA lesions. In this study, we describe the isolation of a cDNA encoding a full-length version of Xenopus ATM. Using antibodies against the regulatory domain of ATM, we have identified the essential replication protein Mcm2 as an ATM-binding protein in Xenopus ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2004 - Elsevier BV | Journal of Biological Chemistry
Tamaki Yano, Sonia López de Quinto, Yasuhisa Matsui, Anna Shevchenko, Andriy Shevchenko, Anne Ephrussi,
Tópico(s): Developmental Biology and Gene Regulation
2004 - Elsevier BV | Developmental Cell
Josephine N. Harada, Anna Shevchenko, Andriy Shevchenko, David C. Pallas, Arnold Berk,
ABSTRACT During the early phase of infection, the E1B-55K protein of adenovirus type 5 (Ad5) counters the E1A-induced stabilization of p53, whereas in the late phase, E1B-55K modulates the preferential nucleocytoplasmic transport and translation of the late viral mRNAs. The mechanism(s) by which E1B-55K performs these functions has not yet been clearly elucidated. In this study, we have taken a proteomics-based approach to identify and characterize novel E1B-55K-associated proteins. A multiprotein ...
Tópico(s): Ubiquitin and proteasome pathways
2002 - American Society for Microbiology | Journal of Virology
Jennitte Stevens, Greg Cantin, Gang Wang, Andrej Shevchenko, Andriy Shevchenko, Arnold Berk,
Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans . We generated sur2 −/− embryonic stem cells to analyze its function as a mammalian Mediator component. Our results show that Sur2 forms a subcomplex of the Mediator with two other subunits, TRAP/Med100 and 95. Knock-out of Sur2 prevents activation by E1A-CR3 and the mitogen-activated protein kinase–regulated ...
Tópico(s): CRISPR and Genetic Engineering
2002 - American Association for the Advancement of Science | Science
Jae Hong Seol, Anna Shevchenko, Andriy Shevchenko, Raymond J. Deshaies,
Tópico(s): Ubiquitin and proteasome pathways
2001 - Nature Portfolio | Nature Cell Biology
Assen Roguev, Daniel Schaft, Anna Shevchenko, Rein Aasland, Andriy Shevchenko, A. Francis Stewart,
Histone 3 lysine 4 (H3 Lys(4)) methylation in Saccharomyces cerevisiae is mediated by the Set1 complex (Set1C) and is dependent upon ubiquitinylation of H2B by Rad6. Mutually exclusive methylation of H3 at Lys(4) or Lys(9) is central to chromatin regulation; however, S. cerevisiae lacks Lys(9) methylation. Furthermore, a different H3 Lys(4) methylase, Set 7/9, has been identified in mammals, thereby questioning the relevance of the S. cerevisiae findings for eukaryotes in general. We report that the ...
Tópico(s): Cancer-related gene regulation
2003 - Elsevier BV | Journal of Biological Chemistry
Andrej Shevchenko, Igor Chernushevich, Andriy Shevchenko, Matthias Wilm, Matthias Mann,
Tópico(s): Molecular Biology Techniques and Applications
2002 - Springer Science+Business Media | Molecular Biotechnology
Adam Liska, А. В. Попов, Shamil Sunyaev, Peg Coughlin, Bianca Habermann, Anna Shevchenko, Peer Bork, Eric Karsenti, Andriy Shevchenko,
Abstract The application of functional proteomics to important model organisms with unsequenced genomes is restricted because of the limited ability to identify proteins by conventional mass spectrometry (MS) methods. Here we applied MS and sequence‐similarity database searching strategies to characterize the Xenopus laevis microtubule‐associated proteome. We identified over 40 unique, and many novel, microtubule‐bound proteins, as well as two macromolecular protein complexes involved in protein ...
Tópico(s): Protein Structure and Dynamics
2004 - Wiley | PROTEOMICS
Assen Roguev, Anna Shevchenko, Daniel Schaft, Henrik Thomas, A. Francis Stewart, Andriy Shevchenko,
The sequential application of protein tagging, affinity purification, and mass spectrometry enables highly accurate charting of proteomic environments by the characterization of stable protein assemblies and the identification of subunits that are shared between two or more protein complexes, termed here "proteomic hyperlinks." We have charted the proteomic environments surrounding the histone methyltransferase, Set1, in both yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe. Although ...
Tópico(s): Bioinformatics and Genomic Networks
2003 - Elsevier BV | Molecular & Cellular Proteomics
Anna Shevchenko, Alexander Loboda, Werner Ens, Burkhart Schraven, Kenneth G. Standing, Andriy Shevchenko,
Mass spectrometry was applied to identify protein spots excised from an archived two-dimensional polyacrylamide gel that had been dried and stored for eight years at room temperature. All proteins were successfully identified. Detailed characterization of protein digests by matrix-assisted laser desorption/ionization (MALDI) peptide mapping, nanoelectrospray tandem mass spectrometry and MALDI-quadrupole time-of-flight mass spectrometry revealed no evidence of protein degradation or modifications ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2001 - Wiley | Electrophoresis
Ines Wagner, Heng Wang, Philipp M. Weissert, Werner L. Straube, Anna Shevchenko, Marc Gentzel, Gonçalo Brito, Akira Tazaki, Catarina R. Oliveira, Takuji Sugiura, Andriy Shevchenko, András Simon, David Drechsel, Elly M. Tanaka,
Limb amputation in the newt induces myofibers to dedifferentiate and re-enter the cell cycle to generate proliferative myogenic precursors in the regeneration blastema. Here we show that bone morphogenetic proteins (BMPs) and mature BMPs that have been further cleaved by serum proteases induce cell cycle entry by dedifferentiating newt muscle cells. Protease-activated BMP4/7 heterodimers that are present in serum strongly induced myotube cell cycle re-entry with protease cleavage yielding a 30-fold ...
Tópico(s): Pluripotent Stem Cells Research
2017 - Elsevier BV | Developmental Cell
Anna Shevchenko, Yimin Yang, Andrea Knaust, Henrik Thomas, Hongen Jiang, Enguo Lü, Changsui Wang, Andriy Shevchenko,
We report on the geLC–MS/MS proteomics analysis of cereals and cereal food excavated in Subeixi cemetery (500–300 BC) in Xinjiang, China. Proteomics provided direct evidence that at the Subexi sourdough bread was made from barley and broomcorn millet by leavening with a renewable starter comprising baker's yeast and lactic acid bacteria. The baking recipe and flour composition indicated that barley and millet bread belonged to the staple food already in the first millennium BC and suggested the role ...
Tópico(s): Identification and Quantification in Food
2013 - Elsevier BV | Journal of Proteomics
Produção Nacional
Revisado por pares
Anna Shevchenko, Mirta Mittelstedt Leal de Sousa, Patrice Waridel, Silvia Tolfo Bittencourt, Marcelo Valle de Sousa, Andriy Shevchenko,
Using a combination of tandem mass spectrometric sequencing and sequence similarity searches, we characterized the larvae venom of the moth Cerodirphia speciosa, which belongs to the Saturniidae family of the Lepidoptera order. Despite the paucity of available database sequence resources, the approach enabled us to identify 48 out of 58 attempted spots on its two-dimensional gel electrophoresis map, which represented 37 unique proteins, whereas it was only possible to identify 13 proteins by conventional ...
Tópico(s): Venomous Animal Envenomation and Studies
2005 - American Chemical Society | Journal of Proteome Research
Anna Shevchenko, Yimin Yang, Andrea Knaust, Jean‐Marc Verbavatz, Huijuan Mai, Bo Wang, Changsui Wang, Andriy Shevchenko,
Lamp illuminants evidence the exploitation of natural resources, animal and plant domestication, commerce, religious practices and nutrition of ancient populations. However, the physicochemical analysis of their major constituent-burned, degraded and aged mixture of triacylglycerols is imprecise and may lead to ambiguous interpretations. We applied proteomics to analyze fuel deposits from eight lamps dated by 6th to 8th centuries AD that were excavated at the Astana necropolis (Xinjiang, China) and ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2017 - Public Library of Science | PLoS ONE
Radosław Kołkowski, Tommi K. Hakala, Andriy Shevchenko, Mikko J. Huttunen,
Optical metasurfaces have recently emerged as the game changer in light manipulation and opened up new perspectives in many subfields of optics and photonics. Recent developments in nonlocal metasurfaces, in which the nanoscale building blocks respond to the incoming light collectively rather than as individual objects, are especially promising for enhancing and controlling the nonlinear optical phenomena. In this article, we provide a brief overview of the basic principles of nonlocal metasurfaces ...
Tópico(s): Nonlinear Photonic Systems
2023 - American Institute of Physics | Applied Physics Letters
Antti Hannonen, Kimmo Saastamoinen, Lasse-Petteri Leppänen, Matias Koivurova, Andriy Shevchenko, Ari T. Friberg, Tero Setälä,
Abstract Beating is a simple physical phenomenon known for long in the context of sound waves but remained surprisingly unexplored for light waves. When two monochromatic optical beams of different frequencies and states of polarization interfere, the polarization state of the superposition field exhibits temporal periodic variation—polarization beating. In this work, we reveal a foundational and elegant phase structure underlying such polarization beating. We show that the phase difference over ...
Tópico(s): Random lasers and scattering media
2019 - IOP Publishing | New Journal of Physics
Andriy Shevchenko, M. Roussey, Ari T. Friberg, Tero Setälä,
Light produced by most natural and artificial sources is unpolarized or partially polarized. At any instant of time, however, such random light can be regarded as fully polarized, but the polarization state may vary drastically within short time intervals. This rate of change is another attribute that separates one unpolarized beam from another. Here, we study such polarization dynamics and, for the first time to our knowledge, measure the characteristic time, called the polarization time, in which ...
Tópico(s): Photonic and Optical Devices
2017 - Optica Publishing Group | Optica
Andriy Shevchenko, Ville Kivijärvi, Patrick Grahn, M. Kaivola, Klas Lindfors,
As metamaterials research continues to evolve, we may consider effects and systems that go beyond the electric-dipole approximation. The authors fabricate an optical metasurface in which nanoscale artificial metamolecules exhibit a dominant electric-current quadrupolar response at visible wavelengths, and the optical reflection and absorption change considerably when the illumination direction is reversed. This bifacial metasurface could be applied in interferometric devices and coatings, solar ...
Tópico(s): Antenna Design and Analysis
2015 - American Physical Society | Physical Review Applied