Lise Gutknecht, Naozumi Araragi, S. Merker, Jonas Waider, Frank M. J. Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, M. Hamon, Angelika Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus‐Peter Lesch,
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological mechanisms to complex behaviors, including neuropsychiatric conditions, as well as in developmental processes. Increasing evidence links 5-HT signaling alterations during development to emotional dysregulation and psychopathology in adult age. To further analyze the importance of brain 5-HT in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic ...
Tópico(s): Neuroscience and Neuropharmacology Research
2012 - Public Library of Science | PLoS ONE
Jonas Waider, Sandy Popp, Boris Mlinar, Alberto Montalbano, Francesco Bonfiglio, Benjamin Aboagye, Elisabeth Thuy, Raphael Kern, Christopher Thiel, Naozumi Araragi, Evgeniy Svirin, Angelika G. Schmitt-Böhrer, Renato Corradetti, Christopher A. Lowry, Klaus‐Peter Lesch,
Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood. Here, we investigated the impact of constitutively inactivated 5-HT synthesis on context-dependent fear learning and extinction using tryptophan hydroxylase 2 (Tph2) knockout mice. Fear conditioning and context-dependent fear memory extinction paradigms were combined ...
Tópico(s): Neuroscience and Neuropharmacology Research
2019 - Frontiers Media | Frontiers in Neuroscience