Josefina Nyström, Ann-Christine Svensk, Britta Lindholm‐Sethson, Paul Geladi, Johan Larson, Lars Franzén,
A non-blinded three armed study of the effect of Aloe vera, Essex and no lotion on erythema was performed. The erythema is an effect of radiotherapy treatment in breast cancer patients. The study required testing of objective methods for measuring the erythema. The chosen experimental methods were Near Infrared Spectroscopy, Laser Doppler Imaging and Digital Colour Photography. The experimental setup was made in such a way that in parallel with testing the effect of the lotions there was also a ...
Tópico(s): Ginseng Biological Effects and Applications
2007 - Taylor & Francis | Acta Oncologica
Jessica Nordlund, Yanara Marincevic-Zuniga, Lucia Cavelier, Amanda Raine, Tom Martin, Anders Lundmark, Jonas Abrahamsson, Ulrika Norén‐Nyström, Gudmar Lönnerholm, Ann‐Christine Syvänen,
Abstract Structural chromosomal rearrangements that can lead to in-frame gene-fusions are a leading source of information for diagnosis, risk stratification, and prognosis in pediatric acute lymphoblastic leukemia (ALL). Traditional methods such as karyotyping and FISH struggle to accurately identify and phase such large-scale chromosomal aberrations in ALL genomes. We therefore evaluated linked-read WGS for detecting chromosomal rearrangements in primary samples of from 12 patients diagnosed with ...
Tópico(s): Prenatal Screening and Diagnostics
2020 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Pär Hallberg, J. Karlsson, Lars Lind, Karl Michaëlsson, Lisa Kurland, Thomas Kahan, Karin Malmqvist, K. Peter Öhman, Fredrik H. Nyström, Ulrika Liljedahl, Ann‐Christine Syvänen, Håkan Melhus,
Abstract Background : Studies suggest that endothelin‐1 contributes to the pathogenesis of hypertension. A G5665T gene polymorphism of preproendothelin‐1 has been shown to be associated with higher blood pressure in overweight patients. No study has yet determined the effect of this polymorphism on the change in blood pressure during antihypertensive treatment. Hypothesis : This study aimed to determine this effect in hypertensive patients with left ventricular (LV) hypertrophy during antihypertensive ...
Tópico(s): Cardiovascular and exercise physiology
2004 - Wiley | Clinical Cardiology
Produção Nacional
Ulrika Liljedahl, Julia Karlsson, Håkan Melhus, Lisa Kurland, Marie Lindersson, Thomas Kahan, Fredrik H. Nyström, Lars Lind, Ann‐Christine Syvänen,
We aimed to develop a microarray genotyping system for multiplex analysis of a panel of single nucleotide polymorphisms (SNPs) in genes encoding proteins involved in blood pressure regulation, and to apply this system in a pilot study demonstrating its feasibility in the pharmacogenetics of hypertension. A panel of 74 SNPs in 25 genes involved in blood pressure regulation was selected from the SNP databases, and genotyped in DNA samples of 97 hypertensive patients. The patients had been randomized ...
Tópico(s): Genetic Associations and Epidemiology
2003 - Lippincott Williams & Wilkins | Pharmacogenetics
Pär Hallberg, Lars Lind, Karl Michaëlsson, Lisa Kurland, Thomas Kahan, Karin Malmqvist, K. Peter Öhman, Fredrik H. Nyström, Ulrika Liljedahl, Ann‐Christine Syvänen, Håkan Melhus,
Adipocyte-derived leucine aminopeptidase (ALAP) is a recently identified member of the M1 family of zinc-metallopeptidases and is thought to play a role in blood pressure control through inactivation of angiotensin II and/or generation of bradykinin. The enzyme seems to be particularly abundant in the heart. Recently, the Arg528-encoding allele of the ALAP gene was shown to be associated with essential hypertension. We evaluated the influence of this polymorphism on the change in left ventricular ...
Tópico(s): Neuropeptides and Animal Physiology
2003 - BioMed Central | BMC Cardiovascular Disorders
Produção Nacional
Revisado por pares
Pär Hallberg, Lars Lind, Katarina Billberger, Karl Michaëlsson, Julia Karlsson, Lisa Kurland, Thomas Kahan, Karin Malmqvist, K. Peter Öhman, Fredrik H. Nyström, Ulrika Liljedahl, Ann‐Christine Syvänen, Håkan Melhus,
Angiotensin II, via the angiotensin II type 1 (AT1) receptor, may mediate myocardial fibrosis and myocyte hypertrophy seen in hypertensive left ventricular (LV) hypertrophy through production of transforming growth factor beta1 (TGF-beta1); AT1-receptor antagonists reverse these changes. The TGF-beta1 G + 915C polymorphism is associated with interindividual variation in TGF-beta1 production. No study has yet determined the impact of this polymorphism on the response to antihypertensive treatment.We aimed ...
Tópico(s): TGF-β signaling in diseases
2004 - Wiley | Clinical Cardiology
Per Olov Österlind, Irina Alafuzoff, Ann‐Christine Löfgren, Stefan L. Marklund, Lennart Nyström, Per‐Olof Sandman, Bertil Steen, Bengt Winblad,
The reference intervals of 18 blood components were established for an elderly population in the 8th decade of life. The most significant findings were a broader range of values for most of the components, lower values of plasma folate and plasma potassium and higher values of erythrocyte sedimentation rate, plasma creatinine and serum cholesterol, the lattermost in women only, compared to younger people.
Tópico(s): Body Composition Measurement Techniques
1984 - Karger Publishers | Gerontology
Shumaila Sayyab, Anders Lundmark, Malin Larsson, Markus Ringnér, Sara Nystedt, Yanara Marincevic-Zuniga, Katja Pokrovskaja Tamm, Jonas Abrahamsson, Linda Fogelstrand, Mats Heyman, Ulrika Norén‐Nyström, Gudmar Lönnerholm, Arja Harila‐Saari, Eva Berglund, Jessica Nordlund, Ann‐Christine Syvänen,
Abstract The mechanisms driving clonal heterogeneity and evolution in relapsed pediatric acute lymphoblastic leukemia (ALL) are not fully understood. We performed whole genome sequencing of samples collected at diagnosis, relapse(s) and remission from 29 Nordic patients. Somatic point mutations and large-scale structural variants were called using individually matched remission samples as controls, and allelic expression of the mutations was assessed in ALL cells using RNA-sequencing. We observed ...
Tópico(s): Genomics and Rare Diseases
2021 - Nature Portfolio | Scientific Reports
Olga Krali, Yanara Marincevic-Zuniga, Gustav Arvidsson, Anna Pia Enblad, Anders Lundmark, Shumaila Sayyab, Vasilios Zachariadis, Merja Heinäniemi, Janne Suhonen, Laura Oksa, Kaisa Vepsäläinen, Ingegerd Öfverholm, Gisela Barbany, Ann Nordgren, Henrik Lilljebjörn, Thoas Fioretos, Hans O. Madsen, Hanne Vibeke Marquart, Trond Flægstad, Erik Forestier, Ólafur G. Jónsson, Jukka Kanerva, Olli Lohi, Ulrika Norén‐Nyström, Kjeld Schmiegelow, Arja Harila‐Saari, Mats Heyman, Gudmar Lönnerholm, Ann‐Christine Syvänen, Jessica Nordlund,
Abstract Genomic analyses have redefined the molecular subgrouping of pediatric acute lymphoblastic leukemia (ALL). Molecular subgroups guide risk-stratification and targeted therapies, but outcomes of recently identified subtypes are often unclear, owing to limited cases with comprehensive profiling and cross-protocol studies. We developed a machine learning tool (ALLIUM) for the molecular subclassification of ALL in retrospective cohorts as well as for up-front diagnostics. ALLIUM uses DNA methylation ...
Tópico(s): Epigenetics and DNA Methylation
2023 - Nature Portfolio | npj Precision Oncology
J Ulrich, H.B. Stähelin, Daniel Hollander, Violleta D. Dadufalza, Heiko Braak, E.W.M.T. ter Braak, H. Strenge, N. Koppang, Katsuiku Hirokawa, Masanori Utsuyama, Hiroshi Gotô, Kazunao Kuramoto, Beat M. Riederer, C.G. Honegger, Hans Jakob Tobler, J. Ulrich, Mark E. Leithe, James Hermiller, Raymond D. Magorien, Donald V. Unverferth, Carl V. Leier, Per Olov Österlind, Irina Alafuzoff, Ann‐Christine Löfgren, Stefan L. Marklund, Lennart Nyström, Per‐Olof Sandman, Bertil Steen, Bengt Winblad, E. Vargas, Claire Rothwell, C. Weinkove, Michael Lye, Astrid Norberg, Staffan Sandström, Bo Norberg, Sture Eriksson, Per‐Olof Sandman,
1984 - Karger Publishers | Gerontology
J. Ulrich, H.B. Stähelin, Daniel Hollander, Violleta D. Dadufalza, Heiko Braak, E. Braak, H. Strenge, N. Koppang, Katsuiku Hirokawa, Masanori Utsuyama, Hiroshi Gotô, Kazunao Kuramoto, Beat M. Riederer, C.G. Honegger, Hans Jakob Tobler, J. Ulrich, Mark E. Leithe, James Hermiller, Raymond D. Magorien, Donald V. Unverferth, Carl V. Leier, Per Olov Österlind, Irina Alafuzoff, Ann‐Christine Löfgren, Stefan L. Marklund, Lennart Nyström, Per-Olof Sandman, Bertil Steen, Bengt Winblad, E. Vargas, Claire Rothwell, C Weinkove, Michael Lye, Astrid Norberg, Staffan Sandström, Bo Norberg, Sture Eriksson, Per‐Olof Sandman,
1984 - Karger Publishers | Gerontology
J Ulrich, H.B. Stähelin, Daniel Hollander, Violleta D. Dadufalza, Heiko Braak, E.W.M.T. ter Braak, H. Strenge, N. Koppang, Katsuiku Hirokawa, Masanori Utsuyama, Hiroshi Gotô, Kazunao Kuramoto, Beat M. Riederer, C.G. Honegger, Hans Jakob Tobler, J. Ulrich, Mark E. Leithe, James Hermiller, Raymond D. Magorien, Donald V. Unverferth, Carl V. Leier, Per Olov Österlind, Irina Alafuzoff, Ann‐Christine Löfgren, Stefan L. Marklund, Lennart Nyström, Per‐Olof Sandman, Bertil Steen, Bengt Winblad, E. Vargas, Claire Rothwell, C. Weinkove, Michael Lye, Astrid Norberg, Staffan Sandström, Bo Norberg, Sture Eriksson, Per‐Olof Sandman,
Tópico(s): Aging, Elder Care, and Social Issues
1984 - Karger Publishers | Gerontology