Produção Nacional
Revisado por pares
Chaminda Senaka Ranadheera, Carla A. Evans, Susan Baines, Celso F. Balthazar, Adriano G. Cruz, Erick A. Esmerino, Mônica Q. Freitas, Tatiana Colombo Pimentel, Anna Elizabeth Wittwer, Nenad Naumovski, Juliana S. Graça, Anderson S. Sant’Ana, Said Ajlouni, Todor Vasiljevic,
Abstract Dairy foods, particularly those of bovine origin, are the predominant vehicles for delivery of probiotic bacteria. Caprine (goat) milk also possesses potential for successful delivery of probiotics, and despite its less appealing flavor in some products, the use of goat milk as a probiotic carrier has rapidly increased over the last decade. This review reports on the diversity, applicability, and potential of using probiotics to enhance the sensory properties of goat milk and goat milk‐based ...
Tópico(s): Protein Hydrolysis and Bioactive Peptides
2019 - Wiley | Comprehensive Reviews in Food Science and Food Safety
Produção Nacional
Revisado por pares
Thifany Justo Santos, Juliana Paggiaro, Helhe Daiany Cabral Silva Pimentel, Anna Karla dos Santos Pereira, Grasiele Soares Cavallini, Douglas Henrique Pereira,
Contamination by heavy metal ions, particularly in water resources, is a severe environmental problem. In this study, the interaction of metal ions, namely, Cadmium Cd(II), Mercury Hg(II), and Lead Pb(II), on lignin matrices was investigated based on theoretical calculations. Binding energy (ΔEBind) values proved that the Pb(II) interacted better with lignin matrices than Cd(II) or Hg(II), having energy values between −8.4 kcal mol−1 to −20.2 kcal mol−1. The Gibbs energy (ΔG) and enthalpy (ΔH) values ...
Tópico(s): Advanced Cellulose Research Studies
2021 - Elsevier BV | Journal of Molecular Graphics and Modelling
Andri Papakonstantinou, Nadia Saoudi, Isabel Pimentel, Anna Suñol, Esther Zamora, Carolina Ortiz, Martín Espinosa-Bravo, Vicente Peg, Ana Vivancos, Cristina Saura, Guillermo Villacampa, Mafalda Oliveira,
Circulating tumor DNA (ctDNA) is increasingly being used as a biomarker in early breast cancer (EBC). We performed a systematic review and meta-analysis to investigate the prognostic value of ctDNA in patients with EBC treated with neoadjuvant therapy (NAT). We searched Medline, Web of Science and Embase for observational or interventional studies that included patients with EBC undergoing NAT, reported outcomes related to the predefined endpoints, and had full text articles available. Study selection ...
Tópico(s): Cancer Cells and Metastasis
2022 - Elsevier BV | Cancer Treatment Reviews
Produção Nacional
Revisado por pares
Yilan Fung Boix, Cristiane Pimentel Victório, Anna Carina Antunes e Defaveri, Rosani do Carmo de Oliveira Arruda, Alice Sato, Celso Luiz Salgueiro Lage,
Abstract Rosmarinus officinalis is known for the production of volatile compounds used in medicinal and food preparations. Leaves of R. officinalis are densely covered with capitate and peltate glandular trichomes where biosynthesis of volatiles mainly occurs. This study aims to conduct a morphological assessment to identify anatomical characteristics of both leaves and trichomes, as well as a chemical analysis of leaf volatile compounds, using histochemistry and stem distillation extraction. Specifically, ...
Tópico(s): Phytochemicals and Antioxidant Activities
2011 - Taylor & Francis | Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology
Produção Nacional
Revisado por pares
Soniza Vieira Alves‐Leon, Maria Lúcia Vellutini Pimentel, Gabrielle Sant'Anna, Fabíola Rachid Malfetano, Cláudio Duque Estrada, Thereza Quirico- Santos,
Neuromyelitis optica (NMO) is an inflammatory, demyelinating disease of the central nervous system characterized by the association of a serious myelitis and unilateral or bilateral optic neuritis. The present study aimed to analyze the immunological parameters of NMO patients with diagnosis established based on Wingerchuck et al. (1999) criteria. Production of IgG and IgA antibodies to antigens of MBP, PLP 95-116, MOG 92-106, and the cytokines interleukin-4 (IL-4) and interferon-gamma (INF-gamma) were ...
Tópico(s): Peripheral Neuropathies and Disorders
2008 - Thieme Medical Publishers (Germany) | Arquivos de Neuro-Psiquiatria
Produção Nacional
Revisado por pares
Cássia Pereira Barros, Roberto P.S. Pires, Jonas T. Guimarães, Yuri Abud, Caroline N. Almada, Tatiana Colombo Pimentel, Celso Sant’Anna, Luiz Dione B. De-Melo, Maria Carmela K.H. Duarte, Márcia C. Silva, Anderson S. Sant’Ana, Mônica Q. Freitas, Adriano G. Cruz,
This study aimed to evaluate the effects of ohmic heating (OH) on probiotic inactivation, cell viability and morphology of the probiotic strains Lactobacillus acidophilus LA 05 (LA), Lacticaseibacillus casei 01 (LC), and Bifidobacterium animalis Bb 12 (BA) to develop paraprobiotics. OH at different electric field magnitudes (4, 8, and 12 V/cm at 60 Hz) and conventional heat treatment (CONV) were performed to determine the most adequate condition for the obtainment of paraprobiotics. Analysis of culturability, ...
Tópico(s): Magnetic and Electromagnetic Effects
2020 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Luiz Cláudio Ferreira Pimentel, Anna C. Cunha, Lucas Villas Bôas Hoelz, Henayle Fernandes Canzian, Débora Inácio Leite, Núbia Boechat, Mônica M. Bastos,
The phenylamino-pyrimidine (PAP) nucleus has been demonstrated to be useful for the development of new drugs and is present in a wide variety of antiretroviral agents and tyrosine kinase inhibitors (TKIs). This review aims to evaluate the application of PAP derivatives in drugs and other bioactive compounds. It was concluded that PAP derivatives are still worth exploring, as they may provide highly competitive ATP TKI's with nano/picomolar activity.
Tópico(s): Synthesis and Characterization of Heterocyclic Compounds
2020 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
Mariana Flores Pimentel, Anna Heath, Michael J. Wan, Rowaida Hussein, Kate E. Leahy, H. Robson MacDonald, Erika Tavares, Cynthia VandenHoven, Katelyn MacNeill, Pekka Kannus, Patricia C. Parkin, Elise Héon, Arun Reginald, Ajoy Vincent,
Purpose: To determine the prevalence of choroidal abnormalities (CAs) and Lisch nodules (LNs) in children who met the clinical diagnostic criteria (CDC) alone and those with a molecularly confirmed diagnosis (MCD) of neurofibromatosis type 1 (NF1), and to ascertain any differences between the groups. Methods: This was a cross-sectional observational study. All children who met the CDC and/or had MCD of NF1 and underwent eye examination were included. At least two CAs or LNs between the two eyes were ...
Tópico(s): Meningioma and schwannoma management
2022 - Association for Research in Vision and Ophthalmology | Translational Vision Science & Technology
Produção Nacional
Revisado por pares
Belisa Parmeggiani, Alana Pimentel Moura, Mateus Grings, Anna Paula Bumbel, Leonardo de Moura Alvorcem, Julia Tauana Pletsch, Carolina Gonçalves Fernandes, Ângela Terezinha de Souza Wyse, Moaçir Wajner, Guilhian Leipnitz,
Abstract Sulfite oxidase (SOX) deficiency is an inherited neurometabolic disorder biochemically characterized by tissue accumulation and high urinary excretion of sulfite and thiosulfate. Affected patients present severe neurological dysfunction accompanied by seizures, whose pathophysiology is poorly known. In the present study we evaluated the in vitro effects of sulfite and thiosulfate on important parameters of glutamatergic neurotransmission and redox homeostasis in rat cerebral cortex slices. ...
Tópico(s): Folate and B Vitamins Research
2015 - Wiley | International Journal of Developmental Neuroscience
Tiago Teodoro, Maria A. Nagel, Ruth Geraldes, Teresa White, Ravi Mahalingam, P. P. Batista, Mary Wellish, José Pimentel, Nelly Khmeleva, Anna Heintzman, Luísa Albuquerque, Philip J. Boyer, Alexander Choe, Ana Rita Peralta, Don Gilden,
A 72-year-old man developed clinical features of giant cell arteritis (GCA) and ipsilateral ophthalmic-distribution zoster, followed within 2 weeks by VZV encephalitis and 2 months later by ischemic optic neuropathy. Temporal artery biopsy was histopathologically negative for GCA, but contained VZV antigen and VZV DNA in multiple non-contiguous (skip) areas. The collective clinical and laboratory findings revealed a remarkably close temporal association of zoster, multifocal VZV vasculopathy with ...
Tópico(s): Retinal and Optic Conditions
2014 - Elsevier BV | Journal of the Neurological Sciences
Produção Nacional
Revisado por pares
Ana Laura Pimentel, Larissa Sant Anna Kellermann Carvalho, Samara Silva Marques, Rodrigo Fontanive Franco, Sandra Pinho Silveiro, Roberto Ceratti Manfro, Joíza Lins Camargo,
The role of glycated hemoglobin (A1C) in the screening and diagnosis of posttransplantation diabetes mellitus (PTDM) is still not entirely understood. We evaluated the use of A1C test in renal transplant recipients at four months after transplantation. A total of 122 out of 274 patients without previous diabetes that underwent kidney transplantation were enrolled. ROC curve was used to analyze the performance of A1C to diagnose PTDM considering OGTT as the reference standard. OGTT identified 32 (26. ...
Tópico(s): Diabetes Treatment and Management
2015 - Elsevier BV | Clinica Chimica Acta
Produção Nacional
Revisado por pares
Roberto P.S. Pires, Jonas T. Guimarães, Cássia Pereira Barros, Celso F. Balthazar, Alexandra I.A. Chincha, Mônica Q. Freitas, Maria Carmela K.H. Duarte, Paulo Henrique Fonseca da Silva, Tatiana Colombo Pimentel, Yuri Abud, Celso Sant’Anna, Anderson S. Sant’Ana, Márcia C. Silva, Janaı́na dos Santos Nascimento, Adriano G. Cruz,
The effect of ohmic heating (OH) (50, 55, and 60 °C, 6 V/cm) on the inactivation kinetics (Weibull model) and morphological changes (scanning electron microscopy and flow cytometry) of Salmonella spp. in infant formula (IF) was evaluated. In addition, thermal load indicators (hydroxymethylfurfural and whey protein nitrogen index, HMF, and WPNI) and bioactive compounds (DPPH, total phenolics, ACE, α-amylase, and α-glucosidase inhibitory activities) were also studied. OH presented a more intense inactivation ...
Tópico(s): Radiation Effects and Dosimetry
2021 - Elsevier BV | Food Microbiology
Produção Nacional
Revisado por pares
Marília Berlofa Visacri, G. Ferrari, Pâmela De Souza Dias, Rafaela Pimentel, Cinthia Madeira de Souza, Anna Paula Lourenço Costa, Eder de Carvalho Pincinato, Carmen Sílvia Passos Lima, Priscila Gava Mazzola, Patrícia Moriel,
The aim of this study was to evaluate the quality of life (QOL) of patients with squamous cell carcinoma of the head and neck before and during treatment with high-dose cisplatin and radiotherapy.This was an observational and longitudinal prospective study conducted from June 2011 to March 2013 at the clinical oncology ambulatory unit of a public teaching hospital in São Paulo, Brazil. The University of Washington Quality of Life Questionnaire was used to measure the QOL of patients before and after ...
Tópico(s): Dysphagia Assessment and Management
2015 - Lippincott Williams & Wilkins | Southern Medical Journal
Dhanunjaya Lakkireddy, Darbhamulla V. Nagarajan, Luigi Di Biase, Subba Reddy Vanga, Srijoy Mahapatra, T. Jared Bunch, John Day, David Burkhardt, Linda Umbarger, Raghuveer Dendi, Rhea Pimentel, Loren Berenbom, Martin Emert, Anna Gerken, Sudharani Bommana, Wallace Ray, Donita Atkins, Caroline Murray, Buddhadeb Dawn, Andrea Natale,
Background Patients with prosthetic valves have a high prevalence of atrial fibrillation (AF). We report a multicenter experience of performing pulmonary vein antral isolation (PVAI) in this challenging, high-risk cohort of patients. Objective The purpose of this study was to assess the feasibility, safety, and efficacy of radiofrequency (RF) ablation for sinus rhythm restoration in AF patients with mitral or aortic mechanical prosthetic valves. Methods A total of 50 patients with prosthetic valves ( ...
Tópico(s): Cardiac Valve Diseases and Treatments
2011 - Elsevier BV | Heart Rhythm
Produção Nacional
Revisado por pares
Roland Coras, Onno J. de Boer, Dawna L. Armstrong, Albert J. Becker, Thomas S. Jacques, Hajime Miyata, Maria Thom, Harry V. Vinters, Roberto Spreafico, Büğe Öz, Gianluca Marucci, José Pimentel, Angelika Mühlebner, Josef Zámečnı́k, Anna Maria Buccoliero, Fábio Rogério, Nathalie Streichenberger, Nobutaka Arai, Marianna Bugiani, Silke Vogelgesang, Robert J.B. Macaulay, Carolin Salon, Volkmar Hans, Marc Polivka, Felice Giangaspero, Dyah Fauziah, Jang‐Hee Kim, Lei Liu, Wang Dandan, Jing Gao, Benjamin Lindeboom, Ingmar Blümcke, Eleonora Aronica,
An International League Against Epilepsy (ILAE) consensus classification system for focal cortical dysplasias (FCDs) has been published in 2011 specifying clinicopathologic FCD variants. The aim of the present work was to microscopically assess interobserver agreement and intraobserver reproducibility for FCD categories among an international group of neuropathologists with different levels of experience and access to epilepsy surgery tissue.Surgical FCD specimens covering a broad histopathology spectrum ...
Tópico(s): Genomics and Rare Diseases
2012 - Wiley | Epilepsia
Produção Nacional
Revisado por pares
Annika K. Wefers, Damian Stichel, Daniel Schrimpf, Roland Coras, Mélanie Pagès, Arnault Tauziède‐Espariat, Pascale Varlet, Dániel Schwarz, Figen Söylemezoğlu, Ute Pohl, José Pimentel, Jochen Meyer, Ekkehard Hewer, Anna Sophia Japp, Abhijit Joshi, David Reuß, Annekathrin Reinhardt, Philipp Sievers, M. Belén Casalini, Azadeh Ebrahimi, Kristin Huang, Christian Koelsche, Hu Liang Low, Olinda Rebelo, Dina Marnoto, Albert J. Becker, Ori Staszewski, Michel Mittelbronn, Martin Hasselblatt, Jens Schittenhelm, Edmund Cheesman, Ricardo Santos de Oliveira, R.G.P. Queiroz, Elvis Terci Valera, Volkmar Hans, Andrey Korshunov, Adriana Olar, Keith L. Ligon, Stefan M. Pfister, Zane Jaunmuktane, Sebastian Brandner, Ruth Tatevossian, David W. Ellison, Thomas S. Jacques, Mrinalini Honavar, Eleonora Aronica, Maria Thom, Felix Sahm, Andreas von Deimling, David Jones, Ingmar Blümcke, David Capper,
The “isomorphic subtype of diffuse astrocytoma” was identified histologically in 2004 as a supratentorial, highly differentiated glioma with low cellularity, low proliferation and focal diffuse brain infiltration. Patients typically had seizures since childhood and all were operated on as adults. To define the position of these lesions among brain tumours, we histologically, molecularly and clinically analysed 26 histologically prototypical isomorphic diffuse gliomas. Immunohistochemically, they ...
Tópico(s): Neuroblastoma Research and Treatments
2019 - Springer Science+Business Media | Acta Neuropathologica
Produção Nacional
Daniela Cia Penoni, João Vitor dos Santos Canellas, Marcos Antonio Nunes Costa Silami, Flávia Sader, Gonçalo Sobreira Pimentel, Anna Thereza Thomé Leão,
This study aimed to report the experience of medication-related osteonecrosis of the jaws (MRONJ) in osteoporotic patients for nine years, and their associated initiating factors.The numbers of invasive oral procedures (IOP) (tooth extraction, dental implant placement, and periodontal procedures) and removable prostheses performed from January 2012 to January 2021 were obtained from the digital records of a large public dental center. There were an estimated 6,742 procedures performed in patients under ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2023 - Brazilian Society of Endocrinology and Metabolism | Archives of Endocrinology and Metabolism
Julie van der Zee, Ilse Gijselinck, Lubina Dillen, Tim Van Langenhove, Jessie Theuns, Sebastiaan Engelborghs, Stéphanie Philtjens, Mathieu Vandenbulcke, Kristel Sleegers, Anne Sieben, Veerle Bäumer, Githa Maes, Ellen Corsmit, Barbara Borroni, Alessandro Padovani, Silvana Archetti, Robert Perneczky, Janine Diehl‐Schmid, Alexandre de Mendonça, Gábriel Miltenberger-Miltényi, Sónia Pereira, José Pimentel, Benedetta Nacmias, Silvia Bagnoli, Sandro Sorbi, Caroline Graff, Huei‐Hsin Chiang, Marie Westerlund, Raquel Sánchez‐Valle, Albert Lladó, Ellen Gelpí, Isabel Santana, Maria Rosário Almeida, Beatriz Santiago, Giovanni B. Frisoni, Orazio Zanetti, Cristian Bonvicini, Matthis Synofzik, Walter Maetzler, Jennifer Müller vom Hagen, Lüdger Schöls, Michael T. Heneka, Frank Jessen, Radoslav Matěj, Eva Parobková, Gábor G. Kovács, Thomas Ströbel, Stayko Sarafov, Ivailo Tournev, Albena Jordanova, Adrian Danek, Thomas Arzberger, Gian Maria Fabrizi, Silvia Testi, Éric Salmon, Patrick Santens, Jean‐Jacques Martin, Patrick Cras, Rik Vandenberghe, Peter Paul De Deyn, Marc Cruts, Christine Van Broeckhoven, Julie van der Zee, Ilse Gijselinck, Lubina Dillen, Tim Van Langenhove, Jessie Theuns, Stéphanie Philtjens, Kristel Sleegers, Veerle Bäumer, Githa Maes, Ellen Corsmit, Marc Cruts, Christine Van Broeckhoven, Julie van der Zee, Ilse Gijselinck, Lubina Dillen, Tim Van Langenhove, Stéphanie Philtjens, Jessie Theuns, Kristel Sleegers, Veerle Bäumer, Githa Maes, Marc Cruts, Christine Van Broeckhoven, Sebastiaan Engelborghs, Peter P. De Deyn, Patrick Cras, Sebastiaan Engelborghs, Peter P. De Deyn, Mathieu Vandenbulcke, Mathieu Vandenbulcke, Barbara Borroni, Alessandro Padovani, Silvana Archetti, Robert Perneczky, Janine Diehl‐Schmid, Matthis Synofzik, Walter Maetzler, Jennifer Müller vom Hagen, Lüdger Schöls, Matthis Synofzik, Walter Maetzler, Jennifer Müller vom Hagen, Lüdger Schöls, Michael T. Heneka, Frank Jessen, Alfredo Ramı́rez, Delia Kurzwelly, Carmen Sachtleben, Wolfgang Mairer, Alexandre de Mendonça, Gábriel Miltenberger-Miltényi, Sónia Pereira, Clara Firmo, José Pimentel, Raquel Sánchez‐Valle, Albert Lladó, Anna Antonell, José Luís Molinuevo, Ellen Gelpí, Caroline Graff, Huei‐Hsin Chiang, Marie Westerlund, Caroline Graff, Anne Kinhult Ståhlbom, Håkan Thonberg, Inger Nennesmo, Anne Börjesson‐Hanson, Benedetta Nacmias, Silvia Bagnoli, Sandro Sorbi, Valentina Bessi, Irene Piaceri, Isabel Santana, Beatriz Santiago, Isabel Santana, Maria Helena Ribeiro, Maria Rosário Almeida, Catarina R. Oliveira, João Massano, Carolina Garret, Paula Pires, Giovanni B. Frisoni, Orazio Zanetti, Cristian Bonvicini, Stayko Sarafov, Ivailo Tournev, Albena Jordanova, Ivailo Tournev, Gábor G. Kovács, Thomas Ströbel, Michael T. Heneka, Frank Jessen, Alfredo Ramı́rez, Delia Kurzwelly, Carmen Sachtleben, Wolfgang Mairer, Frank Jessen, Radoslav Matěj, Eva Parobková, Adrian Danel, Thomas Arzberger, Gian Maria Fabrizi, Silvia Testi, Sérgio Ferrari, Tiziana Cavallaro, Éric Salmon, Patrick Santens, Patrick Cras,
We assessed the geographical distribution of C9orf72 G4C2 expansions in a pan-European frontotemporal lobar degeneration (FTLD) cohort (n = 1,205), ascertained by the European Early-Onset Dementia (EOD) consortium. Next, we performed a meta-analysis of our data and that of other European studies, together 2,668 patients from 15 Western European countries. The frequency of the C9orf72 expansions in Western Europe was 9.98% in overall FTLD, with 18.52% in familial, and 6.26% in sporadic FTLD patients. ...
Tópico(s): Connective tissue disorders research
2012 - Wiley | Human Mutation
Helena Pinheiro, Mafalda R. Pimentel, Catarina Sequeira, Luis M. Oliveira, Anna Pezzarossa, William Roman, Edgar R. Gomes,
Skeletal muscle myofibers are large and elongated cells with multiple and evenly distributed nuclei. Nuclear distribution suggests that each nucleus influences a specific compartment within the myofiber and implies a functional role for nuclear positioning. Compartmentalization of specific mRNAs and proteins has been reported at the neuromuscular and myotendinous junctions, but mRNA distribution in non-specialized regions of the myofibers remains largely unexplored. We report that the bulk of mRNAs ...
Tópico(s): Nuclear Structure and Function
2021 - The Company of Biologists | Journal of Cell Science
Cecilia S. Lee, Aaron Lee, Lakshmi Akileswaran, David W. Stroman, Kathryn Najafi-Tagol, Steve Kleiboeker, James Chodosh, Amalia Magaret, Anna Wald, Russell N. Van Gelder, Gregg J. Berdy, James D. Branch, El-Roy Dixon, Shérif M. El-Harazi, Jack V. Greiner, Joshua B Herz, Larry L. Lothringer, Damien C Macaluso, Andrew L. Moyes, George F. Nardin, Bernard R. Perez, Lawerence E. Roel, Syamala H.K. Reddy, Stéphanie Becker, Neil Shmunes, S. Stephen, Michael Tepedino, Jonathan I. Macy, Prashant Garg, Nivedita Patil, Yasmin Bhagat, Malavika Krishnaswamy, Nagappa Somshekhar, Manisha Acharya, Shree Kumar Reddy, Mary B. Abraham, Shobha Kini, Nita Shanbag, Priscilla Biswas, Virendra Agarwal, Anshu Sahai, Pooja Devi, Vupputuri Venkata Lakshmi, Narasimha Rao, Radhika Tandon, Priti Kapadia, Deepak Mehta, Anju Kochar, Adriana dos Santos Forseto, Rubens Belfort, Jacob Moysés Cohen, Ramon Coral Ghanem, Roberta De Ventura, Sérgio Luís Gianotti Pimentel, Sérgio Kwitko, Maria Cristina Nishiwaki Dantas, Anna Maria Hofling-Lima, Walton Nosé, D. Wariyapola, M. Wijetunge, Charith Fonseka, Champa Banagala, K.A. Salvin, D.R. Kodikara,
Purpose To determine host and pathogen factors predictive of outcomes in a large clinical cohort with keratoconjunctivitis. Design Retrospective analyses of the clinical and molecular data from a randomized, controlled, masked trial for auricloscene for keratoconjunctivitis (NVC-422 phase IIB, NovaBay; clinicaltrials.gov identifier, NCT01877694). Participants Five hundred participants from United States, India, Brazil, and Sri Lanka with clinical diagnosis of keratoconjunctivitis and positive rapid ...
Tópico(s): Herpesvirus Infections and Treatments
2018 - Elsevier BV | Ophthalmology
Produção Nacional
Revisado por pares
Eduardo Maffini da Rosa, João Ricardo M. Sant'Anna, Luciana Pimentel Oppermann, Iran Castro,
OBJETIVO: Avaliar o efeito prognóstico da esclerose valvular aórtica na mortalidade e morte de causa cardíaca de pacientes atendidos no Instituto de Cardiologia do Rio Grande do Sul nos anos de 1996 a 2000. MÉTODOS: Estudo de coorte histórico que utilizou informações contidas nos bancos de dados do laboratório de ecocardiografia do Hospital de Cardiologia e nos Registros de Óbitos da Secretária da Saúde do Rio Grande do Sul. O período de avaliação foi de 1996 a 2000. Os desfechos foram morte e morte ...
Tópico(s): Cardiovascular Function and Risk Factors
2007 - Sociedade Brasileira de Cardiologia (SBC) | Arquivos Brasileiros de Cardiologia
Produção Nacional
Revisado por pares
Rafaella Sales, Suzana de Lima, Luiz Stragevitch, Maria Fernanda Pimentel, Anna de Juan,
Near infrared spectroscopy in-line monitoring and modelling of soybean oil methanolysis has been done using multivariate curve resolution alternating least squares (MCR-ALS) with correlation constraint.This constraint allows for quantitation of the methyl ester formed with little calibration effort and the MCR model provides additionally a general description (qualitative and quantitative) of the rest of components in the process.Due to the complexity of this process, which shows components with severe ...
Tópico(s): Water Quality Monitoring and Analysis
2016 - Brazilian Chemical Society | Journal of the Brazilian Chemical Society
Produção Nacional
Simone Birkheur, Paula Cristina de Sousa Faria-Tischer, César Augusto Tischer, Elisângela Flávia Pimentel, Márcio Fronza, Denise Coutinho Endringer, Anna Paola Butera, Renato Ribeiro-Viana,
Bacterial cellulose membrane is a biomaterial with high value in the biomedical field. Many groups have been making efforts to promote chemical modifications of its structure and, consequently, add new characteristics. Recently, our group has developed a methodology to insert monoester succinic acid in bacterial cellulose membrane without disrupting the microfibril network and bind a protein on it. Considering the role of carbohydrates in the molecular recognition process in biological events, we ...
Tópico(s): Surface Modification and Superhydrophobicity
2017 - Elsevier BV | Materials Science and Engineering C
Anna de Serpa Pimentel, Gerry Mshana, Diana Aloyce, Esther Peter, Zaina Mchome, Donati Malibwa, Annapoorna Dwarumpudi, Saidi Kapiga, Heidi Stöckl,
Introduction: Economic abuse is a form of intimate partner violence that still lacks a clear conceptualization and therefore is often overlooked next to physical, sexual and psychological abuse. While existing categorizations recognize economic intimate partner violence as economic control, economic exploitation and employment sabotage, current measurements of economic abuse rarely capture all its forms, and the issue has not been widely explored in low- and middle-income country settings. Methods: ...
Tópico(s): Gender Politics and Representation
2021 - SAGE Publishing | Women s Health
Santiago Rodrigues-Manica, Alexandre Sepriano, Sofía Ramiro, Fernando Pimentel-Santos, Polina Putrik, Elena Nikiphorou, Sam Norton, Anna Moltó, Maxime Dougados, Désirée van der Heijde, Robert Landewé, Filip Van den Bosch, Annelies Boonen,
Objectives To explore the role of individual and country level socioeconomic (SE) factors on employment, absenteeism and presenteeism in patients with spondyloarthritis (SpA) across 22 countries worldwide. Methods Patients with a clinical diagnosis of SpA fulfilling the ASAS classification criteria and in working age (≤65 years) from COMOSPA were included. Outcomes of interest were employment status, absenteeism and presenteeism, assessed by the Work Productivity and Activity Impairment Specific General ...
Tópico(s): Psoriasis: Treatment and Pathogenesis
2018 - BMJ | Annals of the Rheumatic Diseases
Produção Nacional
Revisado por pares
Israel Silva Maia, Mariângela Pimentel Pincelli, Victor Figueiredo Leite, João Eduardo Daud Amadera, Anna Maria Buehler,
To determine whether long-acting muscarinic antagonists (LAMAs) provide superior therapeutic effects over long-acting β2 agonists (LABAs) for preventing COPD exacerbations.This was a systematic review and meta-analysis of randomized clinical trials involving patients with stable, moderate to severe COPD according to the Global Initiative for Chronic Obstructive Lung Disease criteria, treated with a LAMA (i.e., tiotropium bromide, aclidinium, or glycopyrronium), followed for at least 12 weeks and compared ...
Tópico(s): Respiratory Support and Mechanisms
2017 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Produção Nacional
Revisado por pares
Maria Alice Sant' Anna Zarife, Eline Carvalho Pimentel de Oliveira, Jane Maria Santos Leal Romeu, Mitermayer Galvão dos Reis,
É descrito o primeiro caso de detecção do genótipo 4 do vírus da hepatite C (VHC) em Salvador, BA. Foram utilizados os testes de RT-PCR para detecção do VHC-RNA, e o LIPA para genotipagem. O genótipo 4 responde mal ao tratamento, sendo portanto importante a busca ativa dos contactantes.
Tópico(s): Liver Disease Diagnosis and Treatment
2006 - Brazilian Society of Tropical Medicine | Revista da Sociedade Brasileira de Medicina Tropical
Produção Nacional
Revisado por pares
Alana Pimentel Moura, Mateus Grings, Gustavo Flora Marcowich, Anna Paula Bumbel, Belisa Parmeggiani, Leonardo de Moura Alvorcem, Moaçir Wajner, Guilhian Leipnitz,
Tópico(s): Amino Acid Enzymes and Metabolism
2014 - Springer Science+Business Media | Molecular and Cellular Biochemistry
Produção Nacional
William Vieira Cavalcante, Nayara Rodrigues de Farias, Muriel Magda Lustosa Pimentel, Anna Karina César Leandro, Rodrigo Antônio Torres Matos, Raíssa Karolliny Salgueiro Cruz, Roberto Rômulo Ferreira da Silva,
A leishmaniose visceral canina é uma doença de caráter zoonótico, acometendo os seres humanos e diversas espécies de animais silvestres e domésticos. Objetivou-se com o presente estudo realizar uma revisão de literatura sobre o uso da miltefosina no tratamento clínico de cães com leishmaniose visceral. Trata-se de uma revisão de literatura, a qual foi realizada por meio de consultas à periódicos e livros presentes na biblioteca do Cesmac. Foram utilizadas bases de dados como: portal Capes, SCIELO, ...
Tópico(s): Research on Leishmaniasis Studies
2022 - | Arquivos de Ciências Veterinárias e Zoologia da UNIPAR
Produção Nacional
Revisado por pares
Wilian A. Cortopassi, Julia Penna-Coutinho, Anna Caroline Campos Aguiar, André Silva Pimentel, Camilla D. Buarque, Paulo R. R. Costa, Bruna R. M. Alves, Tanos C. C. França, Antoniana U. Krettli,
DNA topoisomerase I from Plasmodium falciparum (PfTopoI), a potential selective target for chemotherapy and drug development against malaria, is used here, together with human Topo I (HssTopoI), for docking, molecular dynamics (MD) studies and experimental assays. Six synthetic isoflavonoid derivatives and the known PfTopoI inhibitors camptothecin and topotecan were evaluated in parallel. Theoretical results suggest that these compounds dock in the binding site of camptothecin and topotecan inside ...
Tópico(s): Synthesis and Biological Evaluation
2014 - Public Library of Science | PLoS ONE