Claire Wood, Tim Cheetham, Kieren G. Hollingsworth, Michela Guglieri, Y. Ailins-Sahun, Sadhanandham Punniyakodi, Anna Mayhew, Volker Straub,
Adolescents with DMD treated with chronic high dose GC therapy typically have profound pubertal delay. Testosterone, the main circulating androgen in men, promotes virilisation and growth with associated accrual of fat-free muscle mass and bone mineral content. Testosterone therapy is routinely used to mimic the normal stages of pubertal development in patients with hypogonadotrophic hypogonadism, androgen deficiency secondary to testicular disease and in constitutional delay of growth and puberty ( ...
Tópico(s): Cardiomyopathy and Myosin Studies
2019 - BioMed Central | BMC Pediatrics
Vadym V. Levterov, Yaroslav Panasiuk, Oleh Shablykin, Oleksandr Stashkevych, Kateryna Sahun, Artur Rassokhin, Iryna V. Sadkova, Dmytro Lesyk, Anna Anisiforova, Yuliia Holota, Petro Borysko, Iryna Bodenchuk, Nataliya M. Voloshchuk, Pavel K. Mykhailiuk,
Abstract We have developed a general and practical approach towards 2‐oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2‐Oxabicyclo[2.1.1]hexanes have been incorporated into the structure of five drugs and three agrochemicals, and validated biologically as bioisosteres of ortho ‐ and meta ‐benzenes.
Tópico(s): Chemistry and Chemical Engineering
2024 - Wiley | Angewandte Chemie International Edition
Valeria Colicchia, Marialaura Petroni, Giulia Guarguaglini, Francesca Sardina, M Sahún-Roncero, Maurizio Carbonari, Biancamaria Ricci, Constantin Heil, Carlo Capalbo, Francesca Belardinilli, Anna Coppa, Giovanna Peruzzi, Isabella Screpanti, Patrizia Lavia, Alberto Gulino, Giuseppe Giannini,
Tópico(s): Neuroblastoma Research and Treatments
2017 - Springer Nature | Oncogene
Marialaura Petroni, Francesca Sardina, Paola Infante, Armando Bartolazzi, Erica Locatelli, Francesca Fabretti, Stefano Di Giulio, Carlo Capalbo, Beatrice Cardinali, Anna Coppa, Alessandra Tessitore, Valeria Colicchia, Maria Sahùn Roncero, Francesca Belardinilli, Lucia Di Marcotullio, Silvia Soddu, Mauro Comes Franchini, Elena Petricci, Alberto Gulino, Giuseppe Giannini,
Abstract MRE11 is a component of the MRE11/RAD50/NBS1 (MRN) complex, whose activity is essential to control faithful DNA replication and to prevent accumulation of deleterious DNA double-strand breaks. In humans, hypomorphic mutations in these genes lead to DNA damage response (DDR)-defective and cancer-prone syndromes. Moreover, MRN complex dysfunction dramatically affects the nervous system, where MRE11 is required to restrain MYCN-dependent replication stress, during the rapid expansion of progenitor ...
Tópico(s): Cancer-related Molecular Pathways
2018 - Springer Nature | Cell Death and Disease
Xin’Ai Zhao, Jonathan Bramsiepe, Matthias Van Durme, Shinichiro Komaki, Maria Ada Prusicki, Daisuke Maruyama, Joachim Forner, Anna Medzihradszky, Erik Wijnker, Hirofumi Harashima, You Lu, Anja Schmidt, Daniela Guthörl, Rosa María Sahún, Yonsheng Guan, Gaëtan Pochon, Ueli Grossniklaus, Thomas Laux, Tetsuya Higashiyama, Jan U. Lohmann, Moritz K. Nowack, Arp Schnittger,
To produce seeds, flowering plants need to specify somatic cells to undergo meiosis. Here, we reveal a regulatory cascade that controls the entry into meiosis starting with a group of redundantly acting cyclin-dependent kinase (CDK) inhibitors of the KIP-RELATED PROTEIN (KRP) class. KRPs function by restricting CDKA;1-dependent inactivation of the Arabidopsis Retinoblastoma homolog RBR1. In rbr1 and krp triple mutants, designated meiocytes undergo several mitotic divisions, resulting in the formation ...
Tópico(s): Plant tissue culture and regeneration
2017 - American Association for the Advancement of Science | Science
María‐Victoria Mateos, Enrique M. Ocio, Anna Sureda, Albert Oriol, Esther González García, María José Moreno, Miquel Granell, Fernando Escalante, Verónica González‐Calle, Laura Rosiñol Dachs, Estrella Carrillo‐Cruz, Joaquín Martínez‐López, María Victoria Dourdil Sahún, Marta Sonia González, Jaime Pérez de Oteyza, Felipe de Arriba, Miguel‐Teodoro Hernández, Aránzazu García Mateo, Ana Pilar González-Rodríguez, Rafael Ríos, Carmen Cabrera, Juan Bargay, Paula Rodríguez‐Otero, Felipe Casado, María Casanova, María Jesús Blanchard, Joan Bladé Creixenti, Juan José Lahuerta, Jesús F. San Miguel,
Introduction: Carfilzomib dosed at 56 mg/m2 twice a week in combination with dexamethasone (Kd) is a standard of care for RRMM after 1-3 prior lines (PL) based on the ENDEAVOR study. Later, the ARROW study showed Kd dosed at 70 mg/m2 weekly to be superior to Kd dosed at 27 mg/m2 twice a week on RRMM patients (pts) after 2-3 PL. On the other side, Cyclophosphamide is an alkylating agent that has been widely combined with proteasome inhibitors and immunomodulatory drugs in MM, improving their efficacy ...
Tópico(s): Natural Compounds in Disease Treatment
2020 - Elsevier BV | Blood
Marialaura Petroni, Maria Sahùn Roncero, Valentina Ramponi, Francesca Fabretti, Vittoria Nicolis di Robilant, Marta Moretti, Vincenzo Alfano, Alessandro Corsi, Simone De Panfilis, Maria Giubettini, Stefano Di Giulio, Carlo Capalbo, Francesca Belardinilli, Anna Coppa, Francesca Sardina, Valeria Colicchia, Flaminia Pedretti, Paola Infante, Beatrice Cardinali, Alessandra Tessitore, Gianluca Canettieri, Enrico De Smaele, Giuseppe Giannini,
Abstract Growth and patterning of the cerebellum is compromised if granule cell precursors do not properly expand and migrate. During embryonic and postnatal cerebellar development, the Hedgehog pathway tightly regulates granule cell progenitors to coordinate appropriate foliation and lobule formation. Indeed, granule cells impairment or defects in the Hedgehog signaling are associated with developmental, neurodegenerative and neoplastic disorders. So far, scant and inefficient cellular models have ...
Tópico(s): Head and Neck Surgical Oncology
2019 - Nature Portfolio | Scientific Reports
Vadym V. Levterov, Yaroslav Panasiuk, Oleh Shablykin, Oleksandr Stashkevych, Kateryna Sahun, Artur Rassokhin, Iryna V. Sadkova, Dmytro Lesyk, Anna Anisiforova, Yuliia Holota, Petro Borysko, Iryna Bodenchuk, Nataliya M. Voloshchuk, Pavel K. Mykhailiuk,
Abstract We have developed a general and practical approach towards 2‐oxabicyclo[2.1.1]hexanes with two and three exit vectors via an iodocyclization reaction. The obtained compounds have been easily converted into the corresponding building blocks for use in medicinal chemistry. 2‐Oxabicyclo[2.1.1]hexanes have been incorporated into the structure of five drugs and three agrochemicals, and validated biologically as bioisosteres of ortho ‐ and meta ‐benzenes.
Tópico(s): Asymmetric Synthesis and Catalysis
2024 - Wiley | Angewandte Chemie