Produção Nacional
Revisado por pares
Paula Fernandes Tavares Cezar de Mello, Thiago Gomes de Toledo-Pinto, Carolinne de Sales Marques, Lucia Elena Alvarado-Arnez, Cynthia Chester Cardoso, Luana Tatiana Albuquerque Guerreiro, Sérgio Luiz Gomes Antunes, Márcia Rodrigues Jardim, Claúdia Covas, Ximena Illaramendi, Ida Maria Foschiani Dias‐Baptista, Patrícia Sammarco Rosa, Sandra Maria Barbosa Durães, Antônio Guilherme Pacheco, Marcelo Ribeiro‐Alves, Euzenir Nunes Sarno, Milton Ozório Moraes,
Mycobacterium leprae infects macrophages and Schwann cells inducing a gene expression program to facilitate its replication and progression to disease. MicroRNAs (miRNAs) are key regulators of gene expression and could be involved during the infection. To address the genetic influence of miRNAs in leprosy, we enrolled 1,098 individuals and conducted a case-control analysis in order to study four miRNAs genes containing single nucleotide polymorphism (miRSNP). We tested miRSNP-125a (rs12975333 G>T), ...
Tópico(s): Infectious Diseases and Tuberculosis
2014 - Public Library of Science | PLoS neglected tropical diseases
Hajar Maleki, Luísa Durães, António Portugal,
Cross-linking of silica aerogels with organic polymers is an effective way to overcome their fragility and poor mechanical properties. It has also been shown that adjusting the nanoskeleton of silica aerogels using different silica precursors can lead to improved mechanical properties, mesoporosity and thermal conductivity. In this paper, the effect of the incorporation of 1,6-bis(trimethoxysilyl)hexane (BTMSH) and 1,4-bis(triethoxysilyl)-benzene (BTESB) into the underlying silica structure of tri- ...
Tópico(s): Surface Modification and Superhydrophobicity
2014 - Elsevier BV | Microporous and Mesoporous Materials
Produção Nacional
Revisado por pares
Vinícius Augusto de Oliveira, Carlos Rogério de Mello, Matheus Fonseca Durães, Antônio Marciano da Silva,
Soil erosion is one of the most significant environmental degradation processes. Mapping and assessment of soil erosion vulnerability is an important tool for planning and management of the natural resources. The objective of the present study was to apply the Revised Universal Soil Loss Equation (RUSLE) using GIS tools to the Verde River Basin (VRB), southern Minas Gerais, in order to assess soil erosion vulnerability. A annual rainfall erosivity map was derived from the geographical model adjusted ...
Tópico(s): Hydrology and Sediment Transport Processes
2014 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
Hajar Maleki, Luísa Durães, António Portugal,
Mechanically reinforced polymer–silica aerogels have been successfully prepared by using surface-initiated reversible addition-fragmentation chain transfer polymerization.
Tópico(s): Surface Modification and Superhydrophobicity
2014 - Royal Society of Chemistry | Journal of Materials Chemistry A
Hajar Maleki, Luísa Durães, António Portugal,
Silica aerogels are lightweight and highly porous materials, with a three-dimensional network of silica particles, which are obtained by extracting the liquid phase of silica gels under supercritical conditions. Due to their outstanding characteristics, such as extremely low thermal conductivity, low density, high porosity and high specific surface area, they have found excellent potential application for thermal insulation systems in aeronautical/aerospace and earthly domains, for environment clean ...
Tópico(s): Silicone and Siloxane Chemistry
2013 - Elsevier BV | Journal of Non-Crystalline Solids
Hajar Maleki, Luísa Durães, António Portugal,
Ambient pressure dried (APD) silica aerogel-like monoliths with different underlying silica structures have been developed through a simple wet chemical approach. The improvement of the mechanical properties was accomplished by cross-linking the silica surface with triacrylate cross-linker. A solvent exchange carried out by soaking the gels in a low surface tension solvent allowed to avoid the nonsafe and costly supercritical drying process. In this context, two different sets of aerogel-like monoliths ...
Tópico(s): Mesoporous Materials and Catalysis
2015 - American Chemical Society | The Journal of Physical Chemistry C
Hajar Maleki, Akhilesh Rai, Sandra Pinto, Marta B. Evangelista, Renato M. S. Cardoso, Cristiana Paulo, Tiago Carvalheiro, Artur Paiva, Mohammad Imani, Abdolreza Simchi, Luísa Durães, António Portugal, Lino Ferreira,
Superparamagnetic iron oxide nanoparticles (SPIONs) functionalized with antimicrobial agents are promising infection-targeted therapeutic platforms when coupled with external magnetic stimuli. These antimicrobial nanoparticles (NPs) may offer advantages in fighting intracellular pathogens as well as biomaterial-associated infections. This requires the development of NPs with high antimicrobial activity without interfering with the biology of mammalian cells. Here, we report the preparation of biocompatible ...
Tópico(s): Silk-based biomaterials and applications
2016 - American Chemical Society | ACS Applied Materials & Interfaces
Hajar Maleki, Luísa Durães, António Portugal,
In this study, a mechanically robust silica aerogel has been successfully prepared based on the integration of a crosslinker in the poly (butyl acrylate) grafted silica network via surface - initiated reversible addition fragmentation chain transfer technique. Substantial improvements regarding the compressive strength with only a slight difference in aerogel physical properties have been achieved.
Tópico(s): Surface Modification and Superhydrophobicity
2016 - Elsevier BV | Materials Letters
Produção Nacional
Revisado por pares
P. C. Magalhães, F. O. M. Durães, Antônio Carlos de Oliveira, E. E. G. e Gama,
Com o objetivo de verificar os efeitos de diferentes tipos de despendoamento no desenvolvimento de plantas e produção de sementes de milho, foi conduzido, um ensaio durante três anos agrícolas. Esse trabalho consistiu de cinco tipos de despendoamento (manual, macho-estéril, arranquio do cartucho, mecânico e testemunha) e três genótipos (linhagens A e B e o híbrido CMS 355), em suas versões férteis e estéreis. Esses tratamentos foram combinados num fatorial 5x3 com quatro repetições, num delineamento ...
Tópico(s): Growth and nutrition in plants
1999 - UNIVERSIDADE DE SÃO PAULO | Scientia Agricola
Ana Borba, João P. Vareda, Luísa Durães, António Portugal, Pedro Simões,
The structural and spectroscopic properties of silica aerogels were studied using complementary approaches, such as Fourier transform infrared spectroscopy and solid-state NMR spectroscopy.
Tópico(s): Inorganic Fluorides and Related Compounds
2017 - Royal Society of Chemistry | New Journal of Chemistry
Produção Nacional
Gustavo Nóriz Berardinelli, Cristovam Scapulatempo‐Neto, Ronilson Oliveira Durães, Marco Antônio de Oliveira, Denise Peixoto Guimarães, Rui Manuel Reis,
Colorectal cancer (CRC) is a leading cause of cancer death worldwide. Microsatellite instability (MSI) is a genetic pathway leading to CRC, associated with particular clinicopathological features, and recently a major biomarker of immunotherapy response. There is little information the frequency MSI among Brazilian CRC patients, and it is still debatable the ideal methodology for MSI screening in countries with limited resources. We proposed to evaluate MSI by molecular and immunohistochemistry (IHC) ...
Tópico(s): Colorectal Cancer Screening and Detection
2018 - Impact Journals LLC | Oncotarget
Produção Nacional
Revisado por pares
Túlio de Lima Campos, Ricardo Durães‐Carvalho, Antônio Mauro Rezende, Otávio Valério de Carvalho, Alain Kohl, Gabriel Luz Wallau, Lindomar Pena,
The rapid worldwide spread of chikungunya (CHIKV), dengue (DENV), and Zika (ZIKV) viruses have raised great international concern. Knowledge about the entry routes and geographic expansion of these arboviruses to the mainland Americas remain incomplete and controversial. Epidemics caused by arboviruses continue to cause socioeconomic burden globally, particularly in countries where vector control is difficult due to climatic or infrastructure factors. Understanding how the virus circulates and moves ...
Tópico(s): Insect symbiosis and bacterial influences
2018 - Hindawi Publishing Corporation | International Journal of Genomics
Produção Nacional
Revisado por pares
Julie Paulin García Rodríguez, Darlon I. Bernardi, Juliana R. Gubiani, Juliana Magalhães de Oliveira, Raquel P. Morais‐Urano, Ariane F. Bertonha, Karin F. Bandeira, Jairo I. Q. Bulla, Lara Durães Sette, Antônio G. Ferreira, João M. Batista, Thayná S. Silva, Raquel Alves dos Santos, Carlos Henrique Gomes Martins, Simone Possedente de Lira, Marcos Guilherme da Cunha, Daniela Barretto Barbosa Trivella, Nathália Grazzia, Natália E. S. Gomes, Fernanda Ramos Gadelha, Danilo C. Miguel, Ana Carolina Guimarães Cauz, Marcelo Brocchi, Roberto G. S. Berlinck,
A new method of screening was developed to generate 770 organic and water-soluble fractions from extracts of nine species of marine sponges, from the growth media of 18 species of marine-derived fungi, and from the growth media of 13 species of endophytic fungi. The screening results indicated that water-soluble fractions displayed significant bioactivity in cytotoxic, antibiotic, anti-Leishmania, anti-Trypanosoma cruzi, and inhibition of proteasome assays. Purification of water-soluble fractions ...
Tópico(s): Marine Sponges and Natural Products
2020 - American Chemical Society | Journal of Natural Products
Paulo Brito, Luísa Durães, António Portugal,
In previous works, a one-dimensional model was built to simulate the nonsteady radial combustion propagation on thin disk-shaped samples of Fe2O3/aluminum thermite mixtures and was successfully tested. Now, the purpose is to extend the referred model to the more sensible two-dimensional features of the samples, maintaining the main characteristics of the previous model: zero-order kinetics, conductive/radiative heat transfer, assumption of phase transitions, temperature and composition dependency ...
Tópico(s): Radiative Heat Transfer Studies
2012 - Begell House | Computational Thermal Sciences An International Journal
Luísa Durães, J. Campos, António Portugal,
Abstract The self‐sustained thermite reaction between iron oxide (Fe 2 O 3 ) and aluminum is a classical source of energy. In this work the radial combustion propagation on thin circular samples of stoichiometric and over aluminized Fe 2 O 3 /Al thermite mixtures is studied. The radial geometry allows an easy detection of sample heterogeneities and the observation of the combustion behavior in their vicinity. The influence of factors like reactant mixtures stoichiometry, samples green density and system ...
Tópico(s): Thermal and Kinetic Analysis
2006 - Wiley | Propellants Explosives Pyrotechnics
Nuno Rocha, Joana P. Mendes, Luísa Durães, Hajar Maleki, António Portugal, Carlos F. G. C. Geraldes, Arménio C. Serra, Jorge F. J. Coelho,
This work reports an efficient method for the preparation of aqueous dispersions of superparamagnetic iron oxide nanoparticles (SPIONs), involving the use of an amphiphilic block copolymer, poly(ethylene glycol)-block-poly(4-vinyl pyridine) (mPEG-b-P4VP). The iron oxide nanoparticles are easily and efficiently dispersed due to the strong direct interaction of the hydrophobic P4VP segments, through complexation with pyridine units of the copolymer. Well-defined block copolymers, having different compositions ...
Tópico(s): Characterization and Applications of Magnetic Nanoparticles
2014 - Royal Society of Chemistry | Journal of Materials Chemistry B
Luísa Durães, Ana Maia, António Portugal,
Aerogels are regarded as one of the most effective thermal insulation materials. Starting from methyltrimethoxysilene (MTMS) as sol–gel precursor, the supercritically dried silica based aerogels exhibit very low density and thermal conductivity, high hydrophobicity and remarkable flexibility, meeting the requirements for weight-sensitive insulation applications, e.g. for Space environments. However, further improvement in the properties of MTMS–derived aerogels may be achieved by using small amounts ...
Tópico(s): Silicone and Siloxane Chemistry
2015 - Elsevier BV | The Journal of Supercritical Fluids
Miguel Bernardes, Cecília Durães, António Oliveira, Maria João Martins, Raquel Lucas, Lúcia Costa, J G L Pereira, Isabel Ramos, José Carlos Machado, F. Simões-Ventura,
Tópico(s): Protease and Inhibitor Mechanisms
2018 - Springer Science+Business Media | Osteoporosis International
Produção Nacional
Revisado por pares
Eli F. Pimenta, Aline Maria de Vita-Marques, Aristeu Gomes Tininis, Mirna Helena Regali Seleghim, Lara Durães Sette, Katyuscya Veloso, Antônio G. Ferreira, David E. Williams, Brian O. Patrick, Doralyn S. Dalisay, Raymond J. Andersen, Roberto G. S. Berlinck,
A fractional factorial design approach has been used to enhance secondary metabolite production by two Penicillium strains. The method was initially used to improve the production of bioactive extracts as a whole and subsequently to optimize the production of particular bioactive metabolites. Enhancements of over 500% in secondary metabolite production were observed for both P. oxalicum and P. citrinum. Two new alkaloids, citrinalins A (5) and B (6), were isolated and identified from P. citrinum cultures ...
Tópico(s): Fungal Biology and Applications
2010 - American Chemical Society | Journal of Natural Products
M.N.C. Ochoa, Luísa Durães, Α. Matos Beja, António Portugal,
Tópico(s): Mesoporous Materials and Catalysis
2011 - Springer Science+Business Media | Journal of Sol-Gel Science and Technology
Paulo Brito, Luísa Durães, J. Campos, António Portugal,
The sensitivity of a one-dimensional model, built to simulate the non-steady radial combustion propagation on thin circular samples of Fe2O3/aluminium thermite mixtures, was tested in relation to its least reliable thermophysical properties and to non-homogeneities in the initial reactant media. Zero order kinetics and conductive/radiative heat transfer were considered. The model is quite insensitive to variations of most of the properties studied. The highest sensitivity detected concerned aluminium ...
Tópico(s): nanoparticles nucleation surface interactions
2007 - Elsevier BV | Chemical Engineering Science
Luísa Durães, M.N.C. Ochoa, António Portugal, Nelson Duarte, J.P. Dias, Nuno Rocha, Jessica Hernández,
In this work, the sol-gel technology is used to produce silica based xerogels and aerogels suitable for insulation applications in Space. The properties of the obtained materials are tailored varying the precursor – Methyltrimethoxysilane (MTMS) or Methyltriethoxysilane (MTES), and the solvent – methanol or ethanol. A two-step acid-base catalyzed synthesis is used, being the obtained gels dried at atmospheric pressure, in the case of xerogels, and in supercritical conditions, for aerogels. Density and ...
Tópico(s): Mesoporous Materials and Catalysis
2010 - Trans Tech Publications | Advances in science and technology
Produção Nacional
Revisado por pares
Roseane Durães Caldeira, Heloísa Bettiol, Marco Antônio Barbieri, J. Terra-Filho, Carlos García, Élcio Oliveira Vianna,
Objectives: To investigate the prevalence and predictors of work related asthma in young adults from the general population. Methods: A total of 1922 subjects randomly selected from a birth cohort 1978/79 in Brazil, aged 23–25 years, completed a respiratory symptoms questionnaire based on the European Community Respiratory Health Survey, and underwent spirometry, bronchial challenge test with methacholine, and skin prick test. For subjects presenting with bronchial hyperresponsiveness, workplace ...
Tópico(s): Indoor Air Quality and Microbial Exposure
2006 - BMJ | Occupational and Environmental Medicine
Produção Nacional
Revisado por pares
João Batista de Sousa, Caio S. Souza, Maria Bianca Fernandes, Leonardo C. Duraes, Rômulo Medeiros de Almeida, Antônio Carlos Nóbrega dos Santos, Eduardo Freitas da Silva, Paulo Gonçalves de Oliveira,
Tópico(s): Colorectal Cancer Treatments and Studies
2014 - Springer Science+Business Media | International Journal of Colorectal Disease
Luísa Durães, Paulo Brito, J. Campos, António Portugal,
A one-dimensional model was built to simulate the non-steady radial combustion propagation on thin circular samples of Fe2O3/Aluminum thermite mixtures. The model considers zero order kinetics and conductive/radiative heat transfer. All the properties of the system are assumed to vary with the temperature and composition during the propagation and phase transitions are also contemplated. These features, not yet considered in the literature, allowed the obtainment of realistic solutions, readily ...
Tópico(s): Advanced ceramic materials synthesis
2006 - Elsevier BV | Computer-aided chemical engineering/Computer aided chemical engineering
Luísa Durães, Telma Matias, R. Patrício, António Portugal,
Abstract Aerogel‐like silica based materials were obtained by microwave drying of the gels synthesized with methyltrimethoxysilane (MTMS) precursor. The microwave drying is an alternative ambient pressure drying technique for these nanostructured materials that allows a fast fine drying stage and avoids the high temperature cycles of conventional evaporative drying. The gels were synthesized by a two‐step acid‐base catalyzed sol‐gel process following the procedures described in an earlier work. After ...
Tópico(s): Mesoporous Materials and Catalysis
2013 - Wiley | Materialwissenschaft und Werkstofftechnik
Produção Nacional
Revisado por pares
Marcos V. de Castro, Laura P. Ióca, David E. Williams, Bruna Zucoloto da Costa, Carolina Megumi Mizuno, Mário F. C. Santos, Karen de Jesus, Éverton L. F. Ferreira, Mirna Helena Regali Seleghim, Lara Durães Sette, Edenir Rodrigues Pereira‐Filho, Antônio G. Ferreira, Natália S. Gonçalves, Raquel Alves dos Santos, Brian O. Patrick, Raymond J. Andersen, Roberto G. S. Berlinck,
Application of a refined procedure of experimental design and chemometric analysis to improve the production of curvularin-related polyketides by a marine-derived Penicillium sp. DRF2 resulted in the isolation and identification of cyclothiocurvularins 6–8 and cyclosulfoxicurvularins 10 and 11, novel curvularins condensed with a mercaptolactate residue. Two additional new curvularins, 3 and 4, are also reported. The structures of the sulfur-bearing curvularins were unambiguously established by analysis ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2016 - American Chemical Society | Journal of Natural Products
Rui Miranda, Carlos Alves, Regina Sousa, António Chaves, Larissa Montenegro, Hugo Peixoto, Dalila Durães, Ricardo J. Machado, António Abelha, Paulo Nováis, José Machado,
To further evolve urban quality of life, this paper explores the potential of crowdsensing and crowdsourcing in the context of smart cities. To aid urban planners and residents in understanding the nuances of day-to-day urban dynamics, we actively pursue the improvement of data visualisation tools that can adapt to changing conditions. An architecture was created and implemented that ensures secure and easy connectivity between various sources, such as a network of Internet of Things (IoT) devices, ...
Tópico(s): Mobile Crowdsensing and Crowdsourcing
2024 - Multidisciplinary Digital Publishing Institute | Electronics
Produção Nacional
Revisado por pares
Élcio Oliveira Vianna, Roseane Durães Caldeira, Manoel Romeu Pereira Gutierrez, Marco Antônio Barbieri, Heloísa Bettiol, Antônio Augusto Moura da Silva,
Respiratory symptoms associated with smoking habit seem to be age dependent. However, there are few reports about the effect of tobacco in young populations. The objective of this study was to analyze the effect of smoking on respiratory symptoms and lung function in 23- to 25-year-old adults in Brazil. This study had a cross-sectional design and included 2063 young people in the city of Ribeirão Preto, São Paulo State.Subjects completed a questionnaire used by the European Community Respiratory ...
Tópico(s): Smoking Behavior and Cessation
2008 - Elsevier BV | The American Journal of the Medical Sciences
Vahe Fahradyan, Sayf Said, Carlos Ordenana, Edoardo Dalla Pozza, Russell S. Frautschi, Eliana F. R. Duraes, Maria Madajka‐Niemeyer, Frank Papay, Antonio Rampazzo, Bahar Bassiri Gharb,
Abstract Ischemia and reperfusion injury remains a significant limiting factor for the successful revascularization of amputated extremities. Ex vivo normothermic perfusion is a novel approach to prolong the viability of the amputated limbs by maintaining physiologic cellular metabolism. This study aimed to evaluate the outcomes of extended ex vivo normothermic limb perfusion (EVNLP) in preserving the viability of amputated limbs for over 24 hours. A total of 10 porcine forelimbs underwent EVNLP. ...
Tópico(s): Cardiac Ischemia and Reperfusion
2020 - Wiley | Artificial Organs