Produção Nacional
Revisado por pares
Sara Maria R. de Sousa, Sérgio Antônio Fernandes, Wagner B. De Almeida, Luciana Guimarães, P. A. S. Abranches, Eduardo Vinícius Vieira Varejão, Clébio S. Nascimento,
The present letter reports, for the first time, results from a theoretical analysis of the inclusion process involving the prilocaine into the p-sulfonic acid calix[6]arene. Structure and stabilization energies were calculated, in both gas and aqueous phases, using a sequential methodology based on semiempirical and Density Functional Theory (DFT) calculations. From the results, a qualitative structure property relationship could be established with some main structural features being relevant for ...
Tópico(s): Surfactants and Colloidal Systems
2016 - Elsevier BV | Chemical Physics Letters
Produção Nacional
Revisado por pares
Carlos Alberto de Carvalho Fraga, Lucas Rodrigues Alves, Luciano Marques-Silva, Adriana Alkmim de Sousa, Antônio Sérgio Barcala Jorge, Sabrina Ferreira de Jesus, Daniel Nogueira Vilela, Ugo Borges Pinheiro, Kimberly Marie Jones, Alfredo Maurício Batista de Paula, André Luiz Sena Guimarães,
Tópico(s): Head and Neck Cancer Studies
2013 - Springer Nature | Clinical Oral Investigations
Produção Nacional
Revisado por pares
Deylane Menezes Teles e Oliveira, Rafael Melo Santos de Serpa Brandão, Luiz Cláudio Demes da Mata Sousa, Francisco das Chagas Alves Lima, Semíramis Jamil Hadad do Monte, Mário Sérgio Coelho Marroquim, Antonio Vanildo de Sousa Lima, Antônio Gilberto Borges Coelho, Jhonatan Matheus Sousa Costa, Ricardo Martins Ramos, Adalberto Socorro da Silva,
HLA epitope analysis emerged as a strategy to determine alloimmune risk in solid organ transplantation. However, it requires not only knowledge on HLA amino acids sequences, but also on HLA three-dimensional structures. Unfortunately, the number of structures available is still unsatisfactory. This work reports the modelling of 106 heterotrimeric (alpha chain + β2M + peptide) HLA class I molecules. The models were generated by homology modelling using Modeller, refined using GalaxyRefine server, heterodimerized ...
Tópico(s): Immunotherapy and Immune Responses
2019 - Elsevier BV | Human Immunology
Produção Nacional
Revisado por pares
Daniel Fonseca de Carvalho, Roberto Araújo de Faria, Sérgio Antônio Veronez de Sousa, Henrique Queiroz Borges,
Realizou-se um estudo para estimar as perdas relativas na produção de milho, provocadas por deficiência hídrica na fase de floração, e espacializar os períodos de veranico, em dias, para perdas de 10, 20, 30 e 50%, na bacia do Rio Verde Grande, MG. A duração do veranico nessa bacia variou de 2 a 4 dias, de 3 a 7 dias, de 4 a 9 dias e de 5 a 11 dias, para perdas na produção de milho, na fase de floração em outubro, de 10, 20, 30 e 50%, respectivamente. A cultura demonstrou ser mais sensível ao veranico ...
Tópico(s): Growth and nutrition in plants
2000 - UNIVERSIDADE FEDERAL DE CAMPINA GRANDE | Revista Brasileira de Engenharia Agrícola e Ambiental
Sérgio Antônio Veronez de Sousa, Fernando Curi Péres,
No trabalho desenvolveu-se um modelo computacional em linguagem Turbo Pascal for Windows, usando o metodo Monte Carlo, com o objetivo de simular a ocorrencia de veranicos e a queda de rendimento decorrente deles, em determinada cultura. A simulacao foi baseada em uma serie historica de sequencia de dias secos (veranicos) e evapotranspiracao diaria. Na avaliacao do modelo, foi estudada a probabilidade de ocorrencia de veranicos e a queda de rendimento de milho em dois periodos de cultivo na regiao ...
Tópico(s): Growth and nutrition in plants
1998 - Embrapa Informação Tecnológica | Pesquisa Agropecuária Brasileira
Produção Nacional
Revisado por pares
Maura Pinheiro Alves, Rafael Locatelli Salgado, Monique Renon Eller, Roberto Sousa Dias, Sérgio Oliveira de Paula, Antônio Fernandes de Carvalho,
This work evaluated the expression and activity of a metalloprotease released by Pseudomonas fluorescens 07A in milk. Low relative expression of the protease by the strain was observed after incubation for 12 h at 25°C while the strain was in the logarithmic growth phase. After 24 h, protease production significantly increased and remained constant for up to 48 h, a time range during which the strain remained in the stationary phase. Conversely, at refrigeration temperatures, at 12 h the strain ...
Tópico(s): Phytase and its Applications
2017 - Elsevier BV | Journal of Dairy Science
Produção Nacional
Revisado por pares
Adriana de Oliveira-Sousa, M. A. S. Silva, Sérgio Antônio Spínola Machado, Luís Alberto Avaca, Pedro de Lima‐Neto,
The IrO2 layer deposited on a Ti substrate for electrocatalysis of the oxygen evolution reaction (OER) in acidic media was obtained from one of three different deposition methods consisting of painting the substrate with the corresponding solutions followed by heat treatment at a temperature range 400–600°C for 1 h. The coating solutions were prepared by dissolving IrCl3 · 3H2O in 15% HCl (traditional method), by dissolving iridium acetylacetonate in isopropanol and acetic acid (inorganic sol–gel method) ...
Tópico(s): Advanced battery technologies research
2000 - Elsevier BV | Electrochimica Acta
Gabriela Teixeira, Paulo Almeida, Clemente Neves Sousa, Paulo Teles, Paulo De Sousa, Luís Loureiro, Sérgio Teixeira, Duarte Rego, Rui Almeida, António Norton de Matos,
Purpose The aim of this study is to validate the current applicability of arteriovenous access banding in high flow access (HFA) and/or haemodialysis access-induced distal ischaemia (HAIDI). Methods This retrospective study was conducted at the GEV (Grupo de Estudos Vasculares) vascular access centre. The clinical records of consecutive patients undergoing banding for HAIDI and HFA symptoms, between June 2011 and January 2015, were reviewed until April 2015. All vascular access patients’ consultation ...
Tópico(s): Vascular anomalies and interventions
2017 - SAGE Publishing | The Journal of Vascular Access
Produção Nacional
Revisado por pares
Bruno Amorim-Carmo, Alessandra Daniele-Silva, Adriana M. S. Parente, Allanny Alves Furtado, Enéas Carvalho, Johny Wysllas de Freitas Oliveira, Elizabeth Cristina Gomes dos Santos, Marcelo Sousa Silva, Sérgio Ruschi Bergamachi Silva, Arnóbio Antônio da Silva-Júnior, Norberto de Kássio Vieira Monteiro, Matheus de Freitas Fernandes‐Pedrosa,
Scorpion venom constitutes a rich source of biologically active compounds with high potential for therapeutic and biotechnological applications that can be used as prototypes for the design of new drugs. The aim of this study was to characterize the structural conformation, evaluate the antimicrobial activity, and gain insight into the possible action mechanism underlying it, for two new analog peptides of the scorpion peptide Stigmurin, named StigA25 and StigA31. The amino acid substitutions in ...
Tópico(s): Biochemical and Structural Characterization
2019 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Produção Nacional
Revisado por pares
Tatiana de Campos, Paula Rodrigues Oblessuc, Danilo Augusto Sforça, Juliana Morini Kupper Cardoso, Renata Moro Baroni, Adna Cristina Barbosa de Sousa, Sérgio Augusto Morais Carbonell, Alisson Fernando Chioratto, Antônio Augusto Franco Garcia, Luciana Benchimol Rubiano, Anete Pereira de Souza,
Tópico(s): Soybean genetics and cultivation
2010 - Springer Science+Business Media | Molecular Breeding
Produção Nacional
Revisado por pares
Laise Rodrigues Reis, Ismael Artur da Costa-Rocha, Ana Carolina Campi‐Azevedo, Vanessa Peruhype-Magalhães, Jordana Grazziela Coelho-dos-Reis, Christiane Costa-Pereira, Dayane Andriotti Otta, Larissa Chaves Freire, Sheila Maria Barbosa de Lima, Adriana de Souza Azevedo, Waleska Dias Schwarcz, Ana Paula Dinis Ano Bom, Andréa Marques Vieira da Silva, Alessandro Fonseca de Souza, Thalita da Matta de Castro, Clara Lucy de Vasconcellos Ferroco, Ana María Bispo de Filippis, Fernanda de Bruycker Nogueira, Akira Homma, Carla Magda Allan Santos Domingues, Eduardo Sérgio Soares Sousa, Luiz Antônio Bastos Camacho, Maria de Lourdes Maia, Andréa Teixeira−Carvalho, Olindo Assis Martins‐Filho,
The present investigation comprised two independent observational arms to evaluate the influence of pre-existing flavivirus humoral immunity and the age-impact on 17DD-YF vaccination immunity. Flavivirus (YFV; DENV; ZIKV) serology and YF-specific cellular immunity was evaluated in 288 children/9Mths–4Yrs and 288 adults/18–49Yrs residents of areas without YFV circulation. Data demonstrated that flavivirus seropositivity at baseline was higher in Adults as compared to Children (26%;87%;67% vs 6%;13%; ...
Tópico(s): Vibrio bacteria research studies
2021 - Elsevier BV | Vaccine
João Fortuna, Filipe Ferreira, Ricardo Gomes, António Sérgio Ferreira, João Borges de Sousa,
In this paper we report results on the use of low cost, open source Unmanned Aerial Vehicles (UAV) for detecting and tracking hammerhead sharks using a digital camera payload. With the prevailing increase in affordability of Unmanned Aerial Systems (UAS) these have gained a widespread appeal and use in civilian, military and academic research scenarios. Moreover these systems have become easier to setup and deploy allowing their use in projects or activities with more limited means of funding. Still, ...
Tópico(s): Underwater Vehicles and Communication Systems
2013 - Elsevier BV | IFAC Proceedings Volumes
Produção Nacional
Revisado por pares
Daniel Lima Gomes, Anselmo Cardoso de Paiva, Aristófanes Corrêa Silva, Geraldo Bráz, João Dallyson Sousa de Almeida, Antônio Sérgio de Araújo, Marcelo Gattas,
This paper presents an approach for annotating real data of power system equipment and has a main goal of improving visualization in outdoor scenarios where lighting presents itself as a problem for the detection of objects. It proposes the creation of object detectors as natural markers using Haar-like features and homomorphic filtering to include real information in an augmented visualization of a substation. The proposed system provides a real-time solution for displaying the data that are acquired ...
Tópico(s): Advanced Image and Video Retrieval Techniques
2018 - Elsevier BV | Computers in Industry
Produção Nacional
Revisado por pares
Leandro Ceotto Freitas‐Lima, Soraya Wilke Saliba, João Marcus Oliveira Andrade, Maria Luisa Oliveira da Cunha, Puebla Cassini‐Vieira, John David Feltenberger, Lucíola S. Barcelos, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Antônio Carlos Pinheiro de Oliveira, Sérgio Henrique Sousa Santos,
Different factors may contribute to the development of neurodegenerative diseases. Among them, metabolic syndrome (MS), which has reached epidemic proportions, has emerged as a potential element that may be involved in neurodegeneration. Furthermore, studies have shown the importance of the sirtuin family in neuronal survival and MS, which opens the possibility of new pharmacological targets. This study investigates the influence of sirtuin metabolic pathways by examining the functional capacities ...
Tópico(s): Biochemical effects in animals
2016 - Springer Science+Business Media | Molecular Neurobiology
Produção Nacional
Revisado por pares
Aline Cristine Garcia de Oliveira, Antonio Sergio Spano Seixas, Cristina Paiva de Sousa, Clóvis Wesley Oliveira de Souza,
Fresh sugarcane juice is sold by street vendors without any heat treatment in São Carlos, São Paulo, Brazil. Twenty-four samples of point-of-sale juice were tested by standard methods to determine heterotrophic bacteria, total and thermo-tolerant coliform counts, Salmonella, and parasites in the juice. 25% of samples showed poor sanitary conditions, with thermo-tolerant coliform levels higher than allowed by Brazilian standards. Salmonella spp. and parasites were absent in all samples. Thermo-tolerant ...
Tópico(s): Salmonella and Campylobacter epidemiology
2006 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Maria de Lourdes Higuchi, JOSÉ M. GÓIS, Márcia Martins Reis, Marília Harumi Higuchi dos Santos, J Diament, JANUÁRIO M. SOUSA, José Antônio Franchini Ramires, Sérgio Almeida de Oliveira,
Mycoplasma pneumoniae (MP) and Chlamydophila pneumoniae (CP) antigens are encountered in complicated atheromas and may be implicated in the diversity of atherosclerotic lesions. Mycoplasma can downregulate the immune system, altering levels of inflammation, which may favor the proliferation of other co‐infectious agents. In the present study we analyze whether initially stable human atheromas exhibit different ratios of MP/CP antigens compared to ongoing atheromatous lesions. Two groups were examined ...
Tópico(s): Microbial infections and disease research
2006 - Wiley | Apmis
Sérgio Lopes, António J. R. Cabral, Bruno de Sousa,
The shortage in human resources for health affects most dramatically developing countries which frequently use community health workers (CHW) as the basis for health programmes and services. The traditional definition refers CHWs as members of the community who are recruited and trained in health prevention and promotion to provide services within their community. In Guinea-Bissau, CHWs play a fundamental role in the diagnosis and treatment of childhood diarrheal diseases - one of the main health problems ...
Tópico(s): Healthcare Systems and Reforms
2014 - BioMed Central | Human Resources for Health
Produção Nacional
Revisado por pares
Terezinha Ruth Marques Rezende, Jodieh O. S. Varejão, Anna Luísa Lacerda de Almeida Sousa, Sandra Milena Bonilla Castañeda, Sérgio Antônio Fernandes,
The catalyst p-sulfonic acid calix[4]arene was effectively used in the three-component Povarov reaction between aromatic anilines and two equivalents of 2,3-dihydrofuran to obtain furano[3,2-c]-1,2,3,4-tetrahydroquinolines. These reactions proceeded efficiently using water as a green solvent and nontoxic catalysts that could be efficiently reused; the reactions were metal-free and used only inexpensive and easily available compounds. Together with a simple workup procedure, these advantages make ...
Tópico(s): Sulfur-Based Synthesis Techniques
2019 - Royal Society of Chemistry | Organic & Biomolecular Chemistry
Produção Nacional
Revisado por pares
Francilio Carvalho Oliveira, Jancineide Oliveira de Carvalho, Suziete B.S. Gusmão, Lícia de Sousa Gonçalves, Lianna Martha Soares Mendes, Sérgio Antônio Pereira Freitas, G.O.M. Gusmão, Bartolomeu C. Viana, Fernanda Roberta Marciano, Anderson Oliveira Lobo,
It has been difficult to find bioactive compounds that can optimize bone repair therapy and adequate osseointegration for people with osteoporosis. The nano-hydroxyapatite (nHAp)/carbon nanotubes with graphene oxides, termed graphene nanoribbons (GNR) composites have emerged as promising materials/scaffolds for bone regeneration due to their bioactivity and osseointegration properties. Herein, we evaluated the action of nHAp/GNR composites (nHAp/GNR) to promote bone regeneration using an osteoporotic ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2019 - Dove Medical Press | International Journal of Nanomedicine
Produção Nacional
Revisado por pares
Cristiane Moutinho Lagos de Melo, Iranildo José da Cruz Filho, Georon Ferreira de Sousa, Guilherme Antonio de Souza Silva, Dayane Kelly Dias do Nascimento Santos, Ricardo Sérgio da Silva, Bruna Rodrigues de Sousa, Reginaldo Gonçalves de Lima-Neto, Maria do Carmo Alves de Lima, George Jackson de Moraes Rocha,
Caesalpinia pulcherrima is a shrub with worldwide distribution used as an ornamental plant. In this study, we extracted a lignin from the C. pulcherrima leaves and investigated its biological functions. The lignin was characterized by FT-IR, UV–Vis, GPC, TGA and nuclear magnetic resonance (1H and 13C). The antioxidant activity was evaluated using phosphomolybdenum complexation methods (TAA), sequestration of DPPH and ABTS radicals, reducing power, formation of nitrite radical and iron chelating activity ( ...
Tópico(s): Bioactive natural compounds
2020 - Elsevier BV | International Journal of Biological Macromolecules
Produção Nacional
Revisado por pares
Gabriel Abranches Dias Castro, Rodrigo Candido Batista, Rita de Cássia Superbi de Sousa, Angélica de Cássia Oliveira Carneiro, Sérgio Antônio Fernandes,
Furfural is a versatile, high-value-added platform molecule that can be produced from five carbon atom (C5) carbohydrates present in lignocellulosic biomass.
Tópico(s): Enzyme Catalysis and Immobilization
2023 - Royal Society of Chemistry | Reaction Chemistry & Engineering
Tópico(s): History, Culture, and Society
1930 - Bordeaux Montaigne University | Bulletin Hispanique
Produção Nacional
Revisado por pares
B. Couto, Regina Coeli dos Santos Goldenberg, Léa Mirian Barbosa da Fonseca, James A. Thomas, Bianca Gutfilen, Célia Maria Coelho Resende, Feliciano Silva de Azevedo, Daniel Mercante, A. Llorente Torres, Henrique Sergio Coelho, Ângelo Maiolino, Alessandra L. dos Anjos Alves, Juliana Vieira Dias, Maria Cláudia Rodrigues Moreira, Ana L. S. B. Sampaio, Maria Auxiliadora Jeunon Sousa, Taís Hanae Kasai-Brunswick, Sérgio Augusto Lopes de Souza, Antônio Carlos Campos de Carvalho, Guilherme Rezende,
Background: Bone marrow-derived cell therapy has been investigated in patients with severe liver disease. Aims: To assess the feasibility, safety and cell kinetics of autologous bone marrow-derived mononuclear cells (BMMCs) infusion in cirrhotic patients. Methods: BMMCs were isolated from autologous bone marrow and 10% of the cells were labelled with 99mTc-SnCl2. Whole body scintigraphy (WBS) was performed 3 and 24 h after infusion via the hepatic artery. Liver function and image were followed during ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2011 - Wiley | Liver International
Produção Nacional
Revisado por pares
Vilma Leite de Sousa Pires, José Reniclebson Feitosa de Souza, Sérgio Botelho Guimarães, Antônio Ribeiro da Silva Filho, José Huygens Parente Garcia, Paulo Roberto Leitão de Vasconcelos,
To investigate the effect of L-alanyl-L-glutamine (L-Ala-Gln) preconditioning in an acute cerebral ischemia/reperfusion (I/R) model in gerbils.Thirty-six Mongolian gerbils (Meriones unguiculatus), (60-100g), were randomized in 2 groups (n=18) and preconditioned with saline 2.0 ml (Group-S) or 0.75g/Kg of L-Ala-Gln, (Group-G) administered into the femoral vein 30 minutes prior to I/R. Each group was divided into three subgroups (n=6). Anesthetized animals (urethane, 1.5g/Kg, i.p.) were submitted to bilateral ...
Tópico(s): Anesthesia and Neurotoxicity Research
2011 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Produção Nacional
Revisado por pares
Maria Sálete Bessa Jorge, Diego Muniz Pinto, Paulo Henrique Dias Quinderé, Antônio Germane Alves Pinto, Fernando Sérgio Pereira de Sousa, Cínthia Mendonça Cavalcante,
As relações de cuidado funcionam como dispositivos eficazes para a promoção da saúde mental e para o desenvolvimento de práticas integrais. Objetiva-se analisar os dispositivos que possibilitam o cuidado em saúde mental no cotidiano do Centro de Atenção Psicossocial (CAPS). Trata-se de uma pesquisa qualitativa de abordagem crítica e reflexiva realizada no CAPS do Município de Sobral-CE. O estudo foi submetido à análise do Comitê de Ética em Pesquisa adequando-se às normas da pesquisa envolvendo seres ...
Tópico(s): Youth, Drugs, and Violence
2011 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Kelly Aparecida Dias, Aline Rosignoli da Conceição, Stephanie Michelin Santana Pereira, Lívya Alves Oliveira, João Vitor da Silva Rodrigues, Roberto Sousa Dias, Sérgio Oliveira de Paula, Antônio José Natali, Sérgio Luís Pinto da Matta, Reggiani Vilela Gonçalves, Elad Tako, Hércia Stampini Duarte Martino, Ceres Mattos Della Lúcia,
(1) Background: Exhaustive exercise can induce muscle damage. The consumption of nutritional compounds with the ability to positively influence the oxidative balance and an exacerbated inflammatory process has been previously studied. However, little is known about the nutritional value of curcumin (CCM) when mixed with whey protein concentrate (WPC). This study was developed to evaluate the effect of CCM-added WPC on inflammatory and oxidative process control and histopathological consequences in ...
Tópico(s): Adipose Tissue and Metabolism
2022 - Multidisciplinary Digital Publishing Institute | Nutrients
Produção Nacional
Revisado por pares
Antônio Gomes dos Santos Neto, Ana Caroline Ferreira Santos, José Antônio de Oliveira, Cristiane Luisa Jost, Camila Silva de Sousa, Marília Oliveira Fonseca Goulart, Antônio Euzébio Goulart Santana, Sergio Yesid Gómez González, Ederson Esteves da Silva, Jéssica E. S. Fonsaca, Sergio H. Domingues, Daiane Fossatti Dall’Oglio, Hector Aguilar Vitorino, Auro Atsushi Tanaka, Franciele de Matos Morawski, Marco Aurélio Suller Garcia,
Multiwalled carbon nanotubes (MWCNTs) are extensively studied due to their enhanced signal response, improved stability, selectivity, and versatility in fabrication, especially combined with designed materials; however, costly and time-consuming preparation are obstacles to their implementation in routine analyses. Therefore, we propose a tungsten oxide (WO3) and reduced graphene oxide (rGO) nanocomposite (WO3-G/MWCNT) that was mixed with MWCNTs and presented interesting results. We prepared the nanocomposite ...
Tópico(s): Conducting polymers and applications
2023 - Elsevier BV | Microchemical Journal
Produção Nacional
Revisado por pares
Thales de Almeida Pinheiro, Antônio Sérgio Barcala-Jorge, João Marcus Oliveira Andrade, Thaísa de Almeida Pinheiro, Emíllio César Neves Ferreira, Thaísa Soares Crespo, Gislaine Cândida Batista-Jorge, Cássio André Vieira, Deborah de Farias Lelis, Alanna Fernandes Paraíso, Ugo Borges Pinheiro, Mariane Bertagnolli, Carlos Juliano Brant Albuquerque, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula, Antônio Prates Caldeira, Sérgio Henrique Sousa Santos,
The main goal of the present study was to evaluate the metabolic profile, inflammatory markers and the gene expression of the renin–angiotensin system (RAS) components in the visceral adipose tissue of eutrophic, obese and malnourished individuals and mice models of obesity and food restriction. Male Swiss mice were divided into eight groups and fed different levels of food restriction (20%, 40%, or 60%) using standard or high-fat diet. Metabolic profile and adipose tissues were assessed. The expression ...
Tópico(s): Adipose Tissue and Metabolism
2017 - Elsevier BV | The Journal of Nutritional Biochemistry
Produção Nacional
Revisado por pares
Fabienne Antunes Ferreira, Raquel Rodrigues de Souza, Bruno de Sousa Moraes, A. Ferreira, Marco Antônio Américo, Sérgio Eduardo Longo Fracalanzza, J. Couceiro, Agnes Marie Sá Figueiredo,
Abstract Background A novel variant of the ST1-SCC mec IV methicillin-resistant Staphylococcus aureus (MRSA) lineage, mostly associated with nosocomial bloodstream infections (BSI), has emerged in Rio de Janeiro. Bacterial biofilm has been considered a major virulence factor in central venous catheter-associated BSI. The mechanisms involved in biofilm formation/accumulation are multifactorial and complex. Studies have suggested that biofilm production was affected in vitro and vivo for agr -null mutants ...
Tópico(s): Streptococcal Infections and Treatments
2013 - BioMed Central | BMC Microbiology
Bruno Bernardes de Jesus, Sérgio Marinho, Sara Azevedo Barros, António Sousa‐Franco, Catarina Alves‐Vale, Tânia Carvalho, Maria Carmo‐Fonseca,
Aging imposes a barrier to somatic cell reprogramming through poorly understood mechanisms. Here, we report that fibroblasts from old mice express higher levels of Zeb2, a transcription factor that activates epithelial-to-mesenchymal transition. Synthesis of Zeb2 protein is controlled by a natural antisense transcript named Zeb2-NAT. We show that transfection of adult fibroblasts with specific LNA Gapmers induces a robust downregulation of Zeb2-NAT transcripts and Zeb2 protein and enhances the reprogramming ...
Tópico(s): Chromosomal and Genetic Variations
2018 - Nature Portfolio | Nature Communications