Produção Nacional
Revisado por pares
Márcia Maria Oliveira Lima, Manoel Otávio da Costa Rocha, Maria Carmo Pereira Nunes, Lidiane Aparecida Pereira de Sousa, Henrique Silveira Costa, Maria Clara N. Alencar, Raquel Rodrigues Britto, Antônio Luiz Pinho Ribeiro,
Aims The effects of exercise training in chronic heart failure are well established, however, they have not been evaluated in Chagas cardiomyopathy (ChC). We sought to determine the effects of exercise training on functional capacity, health‐related quality of life (HQoL), and brain natriuretic peptide (BNP) levels in patients with ChC. Methods and results This randomized, controlled, single‐blind trial included 40 patients with ChC (age 49.5 ± 7.8 years, 57.5% male) who did not practice regular exercise. ...
Tópico(s): Trypanosoma species research and implications
2010 - Elsevier BV | European Journal of Heart Failure
Produção Nacional
Revisado por pares
Lívia Santos Diniz, Victor Ribeiro Neves, Ana C. Starke, Marco Paulo Tomaz Barbosa, Raquel Rodrigues Britto, Antônio Luiz Pinho Ribeiro,
The six-minute walk test (6MWT) is a simple, low cost, reliable, and valid method for evaluating the functional capacity of cardiac patients. However, its early use and safety following acute myocardial infarction (AMI) is recent and has been little investigated. To evaluate and to compare the safety and the cardiac behavior of early performance of the 6MWT in patients following uncomplicated AMI up to 4 days or more than 4 days after the event. Following discharge from the Coronary Care Unit, 152 ...
Tópico(s): Cardiovascular Effects of Exercise
2017 - Elsevier BV | Brazilian Journal of Physical Therapy
Produção Nacional
Revisado por pares
Mirian A.F. Hayashi, Raquel S. Pires, Nancy Amaral Rebouças, Luiz Roberto Britto, Antônio Carlos Martins de Camargo,
Endo-oligopeptidase A (EOPA, formerly EC 3.4.22.19), a thiol-activated oligopeptidase, is able to degrade both bradykinin and neurotensin, and also to convert enkephalin-containing peptides into enkephalins. The expression of this enzyme was studied in the rat brain by in situ hybridization using non-radiotopic probes. The distribution of EOPA transcripts included many regions of the rat central nervous system, with higher expression in some regions, such as the hippocampus, cerebellum, and basal ...
Tópico(s): Signaling Pathways in Disease
2001 - Elsevier BV | Molecular Brain Research
Produção Nacional
Revisado por pares
Emer S. Ferro, Dânia Emi Hamassaki‐Britto, Antônio Carlos Martins de Camargo, Luiz R.G. Britto,
Abstract : Endo‐oligopeptidase A., EC 3.4.22.19, converts small enkephalin‐containing peptides into the corresponding enkephalins in vitro. We investigated the presence of endooligopeptidase A in the retina and its possible colocalization with enkephalins in retinal neurons. The specific activity of endo‐oligopeptidase A found in pigeon retinae (30.3 ± 7.3 mU/mg, mean ± standard deviation) was four times higher than in rabbit retinae (7.0 ± 1.1 mU/mg). The enzyme activity was not modified by EDTA, but it ...
Tópico(s): Biochemical and Structural Characterization
1991 - Wiley | Journal of Neurochemistry
Produção Nacional
Revisado por pares
Karina Ferreira Duarte, Otto Mack Junqueira, Rosemeire da Silva Filardi, Jefferson Costa de Siqueira, Maíra Mangili Puzotti, Edivaldo Antônio Garcia, Andréa de Britto Molino, Antônio Carlos de Laurentiz,
The objective of this experiment was to establish different criteria to evaluate the requirements of digestible tryptophan for broilers from 22 to 42 d of age, using different regression models (quadratic, exponential and Linear Response Plateau) and in case of statistical significance the comparison of means by Duncan test at 5% probability was also adopted. A total of 1,920 Cobb 500 male broilers were distributed in a completely randomized experimental design, with 6 treatments (6 digestible tryptophan ...
Tópico(s): Rabbits: Nutrition, Reproduction, Health
2013 - Sociedade Brasileira de Zootecnia | Revista Brasileira de Zootecnia
Produção Nacional
Revisado por pares
Lidiane Aparecida Pereira de Sousa, Raquel Rodrigues Britto, Antônio Luiz Pinho Ribeiro, Sabrina Mattos Baracho, Vladimir da Costa Val Barros, Vinícius Tostes Carvalho, Verônica Franco Parreira,
The 6-minute walk test (6MWT) is a simple and reliable method routinely used in the evaluation of many conditions including cardiac diseases. However, it is rarely performed in patients with pacemakers (PMs), and the applicability and safety in this group is not established. The purpose of this study was to verify the applicability and safety of the 6MWT in the evaluation of functional capacity of patients with PMs, considering the ergometry test (ET) as the criterion standard.Twenty-four patients ...
Tópico(s): Cardiovascular Function and Risk Factors
2008 - Lippincott Williams & Wilkins | Journal of Cardiopulmonary Rehabilitation and Prevention
Produção Nacional
Revisado por pares
Antônio Britto Casanova, Eduardo Neubarth Trindade, Manoel Roberto Maciel Trindade,
Abstract Background The aim of this study was to analyze the constituents of total and types I and III collagen fibers in the transversalis fascias of patients with indirect inguinal hernias, compared with samples removed from nonherniated cadavers. Methods Biopsy samples from 26 patients and 26 cadavers were analyzed. Hematoxylin-eosin and picrosirius staining techniques were used. The images obtained were analyzed using a video morphometric technique to determine the constituents of total collagen and ...
Tópico(s): Sports injuries and prevention
2008 - Elsevier BV | The American Journal of Surgery
Produção Nacional
Revisado por pares
Marilza da Silva Costa, Jamile Fernanda Silva Cossolin, Mônica Cox de Britto Pereira, Antônio EG Santana, Milena Lima, José Cola Zanuncio, José Éduardo Serrão,
Acetogenins are secondary metabolites exclusively produced by Annonaceae, which have antitumor, cytotoxic, and pesticide activities. In this study, we evaluated the larvicidal and cytotoxic effect of squamocin from Annona squamosa on Aedes aegypti (Diptera: Culicidae) midgut. The compound was solubilized in 2% Tween 20 at 10, 20, 50, 80 and 100 ppm. The assay was conducted in a completely randomized design with four replications, each with 20 third-instar larvae. Larval mortality was assessed every ...
Tópico(s): Cocoa and Sweet Potato Agronomy
2014 - Multidisciplinary Digital Publishing Institute | Toxins
Produção Nacional
Revisado por pares
José Britto‐Júnior, Antonio Tiago Lima, Vivian Fuguhara, Fabíola Z. Mónica, Edson Antunes, Gilberto De Nucci,
6-Nitrodopamine (6-ND) is released from rat isolated atria being 100 times more potent than noradrenaline and adrenaline, and 10,000 times more potent than dopamine as a positive chronotropic agent. The present study aimed to investigate the interactions of 6-ND with the classical catecholamines, phosphodiesterase (PDE)-3 and PDE4, and the protein kinase A in rat isolated atria. Atrial incubation with 1 pM of dopamine, noradrenaline, or adrenaline had no effect on atrial frequency. Similar results ...
Tópico(s): Nitric Oxide and Endothelin Effects
2023 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Produção Nacional
Revisado por pares
Gláucia Vilar-Pereira, Leda Castaño Barrios, Andréa Silva, Angélica Martins Batista, Isabela Resende Pereira, Otacílio C. Moreira, Constança Britto, Hílton Antônio Mata dos Santos, Joseli Lannes-Vieira,
Memory impairment has been associated with chronic Chagas disease (CD), a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi . In degenerative diseases, memory loss has been associated with increased oxidative stress, revealed as enhanced lipid peroxidation, in the cerebral cortex. Benznidazole (Bz), a trypanocidal drug efficient to reduce blood parasite load in the acute and chronic phases of infection, showed controversial effects on heart disease progression, the main clinical ...
Tópico(s): Parasites and Host Interactions
2021 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Marília Vannuchi Tomazini, Cacilda da Silva Souza, Sérgio Britto Garcia, Antônio Cláudio Tedesco,
FUNDAMENTOS - Ftalocianinas são promissores agentes fotossensibilizadores na terapia fotodinâmica (TFD). OBJETIVOS - Avaliar intervalos, veículos e a incorporação de promotor de absorção na formulação tópica da ftalocianina de zinco (FC-Zn). Avaliar alterações macro e micromorfológicas e a expressão de Fas promovidas pela TFD com FC-Zn tópica no modelo murino. MÉTODOS - Por meio da espectrometria de fluorescência, foram avaliadas combinações de diferentes períodos de oclusão tópica das formulações gel ou ...
Tópico(s): Nonmelanoma Skin Cancer Studies
2007 - Elsevier BV | Anais Brasileiros de Dermatologia
Produção Nacional
Revisado por pares
José Britto‐Júnior, Antonio Tiago Lima, J.S. Santos-Xavier, Pedro Luiz Gonzalez, Fabíola Z. Mónica, Rafael Campos, Valéria Barbosa de Souza, André Almeida Schenka, Edson Antunes, Gilberto De Nucci,
6-Nitrodopamine is a novel catecholamine released by vascular tissues, heart, and vas deferens. The aim of this study was to investigate whether 6-nitrodopamine is released from the thoracic aorta and pulmonary artery rings of marmosets (Callithrix spp.) and to evaluate the relaxing and anti-contractile actions of this catecholamine. Release of 6-nitrodopamine, dopamine, noradrenaline, and adrenaline was assessed by liquid chromatography with tandem mass spectrometry (LC-MS/MS). The relaxations induced ...
Tópico(s): Ion channel regulation and function
2023 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Gislaine Ribeiro Pereira, J H Collett, Sérgio Britto Garcia, José Antônio Thomazini, Maria Vitória Lopes Badra Bentley,
Transdermal delivery of most drugs is precluded by the barrier characteristics of the stratum corneum (SC). Chemical penetration enhancers are capable of interacting with SC constituents, inducing a temporary reversible increase in the skin permeability. The aim of this work was to assess the influence of glycerol monooleate (GMO)/solvents systems on percutaneous absorption across hairless mouse SC of a lipophilic drug, progesterone (PG), as well as its effect on the SC structural characteristics, ...
Tópico(s): Contact Dermatitis and Allergies
2002 - UNIVERSIDADE DE SÃO PAULO | Revista Brasileira de Ciências Farmacêuticas
Produção Nacional
Revisado por pares
Rodrigo Paschoal Prado, Sérgio Britto Garcia, José Antônio Thomazini, Carlos Eli Piccinato,
This study aimed to investigate the effect of 830 and 670 nm diode laser on the viability of random skin flaps in rats.Low-level laser therapy (LLLT) has been reported to be successful in stimulating the formation of new blood vessels and reducing the inflammatory process after injury. However, the efficiency of such treatment remains uncertain, and there is also some controversy regarding the efficacy of different wavelengths currently on the market.Thirty Wistar rats were used and divided into ...
Tópico(s): Ocular and Laser Science Research
2012 - Mary Ann Liebert, Inc. | Photomedicine and Laser Surgery
Produção Nacional
Revisado por pares
Antonildes Medeiros Mota Gomes, Érika Bárbara Abreu Fonseca Thomaz, Maria Teresa Seabra Soares de Britto e Alves, Antônio Augusto Moura da Silva, Raimundo Antônio da Silva,
The scope of this study was to evaluate the use of oral health services (OHS) and related factors in municipalities with more than 100,000 inhabitants in Maranhão, Brazil. It was a population-based sample including 1214 children and 1059 adults. Prevalence ratios (PR) were estimated by hierarchical Poisson regression in accordance with Andersen's theoretical model. Over 91% of children and 71.9% of adults had not used the OHS in the six months prior to the interview. Of those who did, 48.5% were attended ...
Tópico(s): Maternal and Neonatal Healthcare
2014 - ASSOCIAÇÃO BRASILEIRA DE SAÚDE COLETIVA | Ciência & Saúde Coletiva
Produção Nacional
Revisado por pares
Renato de A. de Azevedo, Wellington Luiz de Oliveira da Rosa, Adriana Fernandes da Silva, Marcos Britto Corrêa, Marcos Antônio Torriani, Rafael Guerra Lund,
The aim of this study was to review the effectiveness of methods used for teaching dental anatomy carving to dental students in operative dentistry as evaluated in published studies. This systematic review is described in accordance with the PRISMA statement. Two independent reviewers performed a systematic literature search of research published from January 1945 until May 2014. Seven databases were screened: MedLine (PubMed), Lilacs, IBECS, Web of Science, Scopus, SciELO, and The Cochrane Library. ...
Tópico(s): Anatomy and Medical Technology
2015 - Wiley | Journal of Dental Education
Produção Nacional
Revisado por pares
Renato Azevedo de Azevedo, Marcos Britto Corrêa, Marcos Antônio Torriani, Rafael Guerra Lund,
Knowledge of dental anatomy is of great importance in the practice of dentistry, especially in oral rehabilitation, because without this knowledge, professional practice is not possible. Dental carving plays a major role in training dental students as it develops their manual dexterity. This randomized controlled trial aimed to evaluate the influence of didactic‐theoretical reinforcement on the theoretical and practical knowledge of dental anatomy of preclinical students by examining the quality ...
Tópico(s): Innovations in Medical Education
2017 - Wiley | Anatomical Sciences Education
Produção Nacional
Revisado por pares
João Roig Martins, Otacílio Luiz Chagas Júnior, Bibiana Dalsasso Velasques, A Bobrowski, Marcos Britto Corrêa, Marcos Antônio Torriani,
Odontogenic infections are a common problem in dentistry, and their treatment often requires the use of antibiotics besides the removal of the source of infection, which frequently makes it more difficult for clinicians to make a decision regarding the choice of antibiotic. This study aimed to answer the following questions through the Patient, Intervention, Comparison, Outcome (PICO) format: When should antibiotics be used in dental infections (DIs)? Which are the most effective drugs? How long should ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2017 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Produção Nacional
Revisado por pares
Andressa Otranto de Britto Teixeira, Marco Antônio de Oliveira Almeida, Rhita Cristina da Cunha Almeida, Caroline Pelagio Raick Maués, Thaís Pimentel, Danilo Passeado Branco Ribeiro, Paulo José de Medeiros, Cátia Cardoso Abdo Quintão, Felipe de Assis Ribeiro Carvalho,
Tópico(s): Facial Trauma and Fracture Management
2020 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Poliana Cristina de Almeida Fonseca Viola, Carolina Abreu de Carvalho, Maylla Luanna Barbosa Martins Bragança, Ana Karina Texeira da Cunha França, Maria Teresa Seabra Soares de Britto e Alves, Antônio Augusto Moura da Silva,
The aim of this study was to investigate the association between percent contribution of ultra-processed foods to total dietary energy intake and measurements of body composition obtained using high-validity methods. This was a cross-sectional study with 1525 adolescents 18 to 19 y of age from the second follow-up of the 1997/98 São Luís birth cohort, Brazil. To evaluate nutritional status and body composition, the body mass index (BMI)-for-age was used, along with waist circumference, total and ...
Tópico(s): Obesity, Physical Activity, Diet
2020 - Elsevier BV | Nutrition
Produção Nacional
Revisado por pares
Lucas Silva, Dalson Britto Figueiredo Filho, Antônio Alves Tôrres Fernandes,
In response to the COVID-19 pandemic, governments worldwide have implemented social distancing policies with different levels of both enforcement and compliance. We conducted an interrupted time series analysis to estimate the impact of lockdowns on reducing the number of cases and deaths due to COVID-19 in Brazil. Official daily data was collected for four city capitals before and after their respective policies interventions based on a 14 days observation window. We estimated a segmented linear ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz | Cadernos de Saúde Pública
Produção Nacional
Revisado por pares
Caio B. Vianna, Maria Margarita Gonzalez, Luís Alberto Oliveira Dallan, Afonso Akio Shiozaki, Fabio Morais Medeiros, Pedro Carrusca Britto, Luı́z Antonio Machado César,
A previously asymptomatic 15-year-old boy was treated at our institution after an episode of chest pain, palpitation, and syncope while playing in a high school soccer game. The patient's resting electrocardiogram was normal. A transthoracic echocardiogram showed an anomalous left main coronary artery originating from the right sinus of Valsalva. Contrast-enhanced multidetector computed tomography demonstrated clearly that the anomalous vessel coursed between the aorta and the pulmonary trunk (interarterial ...
Tópico(s): Vascular anomalies and interventions
2007 - Elsevier BV | Resuscitation
Produção Nacional
Revisado por pares
Mirian A.F. Hayashi, Alessandra F. Murbach, Danielle Ianzer, Fernanda Calheta Vieira Portaro, Benedito C. Prezoto, Beatriz Lieblich Fernandes, Paulo Flávio Silveira, Carlos Alberto-Silva, Raquel S. Pires, Luiz Roberto Britto, Vincent Dive, Antônio Carlos Martins de Camargo,
Abstract The bradykinin‐potentiating peptides from Bothrops jararaca venom are the most potent natural inhibitors of the angiotensin‐converting enzyme. The biochemical and biological features of these peptides were crucial to demonstrate the pivotal role of the angiotensin‐converting enzyme in blood pressure regulation. In the present study, seven bradykinin‐potentiating peptides were identified within the C‐type natriuretic peptide precursor cloned from snake brain. The bradykinin‐potentiating ...
Tópico(s): Venomous Animal Envenomation and Studies
2003 - Wiley | Journal of Neurochemistry
Produção Nacional
Revisado por pares
Verena R. Juncal, Lelivaldo Antonio de Britto Neto, Aquiles Assunção Camelier, Octávio Messeder, Augusto Manoel de Carvalho Farias,
To describe the clinical characteristics, laboratory data, and clinical outcomes of patients with and without sepsis admitted to the ICU of a private hospital in the city of Salvador, Brazil, and to identify clinical variables related to a worse prognosis in those with sepsis.This was a longitudinal study including all patients admitted to the general ICU of the Hospital Português, in the city of Salvador, Brazil, between June of 2008 and March of 2009. At ICU admission, two groups of patients were ...
Tópico(s): Hemodynamic Monitoring and Therapy
2011 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Produção Nacional
Revisado por pares
Jorge Britto, Marco Antônio Vargas, Carlos Augusto Grabois Gadelha, Laís Silveira Costa,
OBJETIVO: Analisar a evolução recente das competências científicas na área de saúde, o efeito das linhas de fomento na redução dos desequilíbrios científicos regionais e a interação universidade-empresas entre os grupos de pesquisa em saúde no Brasil. MÉTODOS: As informações utilizadas foram provenientes das bases de dados do Conselho Nacional de Desenvolvimento Científico e Tecnológico, referentes aos anos de 2000 a 2010. Foram calculados indicadores relativos à mobilização de recursos, à estruturação ...
Tópico(s): Biotechnology and Related Fields
2012 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Produção Nacional
Revisado por pares
Lidiane Aparecida Pereira de Sousa, Fernando Antônio Botoni, Raquel Rodrigues Britto, Manoel Otávio da Costa Rocha, Antônio Lúcio Teixeira, Mauro Martins Teixeira, Adelina M. Reis, Bráulio Muzzi Ribeiro de Oliveira, Antônio Luiz Pinho Ribeiro,
We studied systematically, for the first time, the utility of the six-minute walk test (6MWT) in Chagas disease. The walked distance at 6MWT correlated negatively with the increased circulating levels of monocyte chemoattractant protein (MCP-1, r=−0.358, p=0.04) and natriuretic peptide type B (BNP, r=−0.349, p=0.04), as well as positively with ejection fraction deterioration (r=0.451, p=0.004), indicating that submaximal functional capacity of chagasic patients is related to the severity of the cardiopathy. ...
Tópico(s): Cardiovascular Function and Risk Factors
2007 - Elsevier BV | International Journal of Cardiology
Produção Nacional
Revisado por pares
Maria Teresa Seabra Soares de Britto e Alves, Antônio Augusto Moura da Silva, Maria Inês Battistella Nemes, Luis Gustavo Oliveira Brito,
INTRODUÇÃO: A mortalidade por Aids no Brasil está decrescendo, principalmente, após a introdução dos anti-retrovirais. Nesse sentido, foi realizado estudo com o objetivo de analisar a incidência e mortalidade, segundo sexo, em uma determinada região do Brasil. MÉTODOS: O estudo foi realizado a partir do número de óbitos ocorrido por Aids na população residente no Estado do Maranhão, segundo sexo, no período de 1985 a 1998. Utilizou-se como numerador a quantidade de óbitos do Sistema de Informação ...
Tópico(s): HIV/AIDS drug development and treatment
2003 - UNIVERSIDADE DE SÃO PAULO | Revista de Saúde Pública
Produção Nacional
Revisado por pares
Julia S. de Britto, Antônio Carlos Augusto da Costa, Aderval S. Luna, Cristiane A. Henriques,
A basic investigation of the removal of Cd(II) and Zn(II) ions from aqueous solutions by Sargassum sp. and NaY zeolite was conducted at room temperature under batch conditions. The results obtained indicated that, for both sorbents, cadmium and zinc ion uptake could be described by the Langmuir adsorption model. The kinetics of the biosorption process followed a pseudo-second-order model, whereas equilibrium in the ion-exchange process was attained so rapidly that the data obtained could not be ...
Tópico(s): Heavy Metal Pollution Remediation
2007 - SAGE Publishing | Adsorption Science & Technology
Produção Nacional
Revisado por pares
José Britto‐Júnior, Antonio Tiago Lima, Rafael Campos, Alexandre Asturiano Gião, Gustavo Duarte Mendes, Luiza P. Ferreira-Novaes Silva, Adriano Fregonesi, André Sampaio Pupo, Edson Antunes, Gilberto De Nucci,
6-Nitrodopamine (6-ND) is a novel endogenous catecholamine that is released from the rat isolated vas deferens, and has been characterized as a major modulator of the contractility of rat isolated epididymal vas deferens (RIEVD). Drugs such as tricyclic antidepressants, α1 and β1β2 adrenoceptor blockers, act as selective antagonists of the 6-ND receptor in the RIEVD. In the rat isolated atria, 6-ND has a potent positive chronotropic action and causes remarkable potentiation of the positive chronotropic ...
Tópico(s): Renin-Angiotensin System Studies
2023 - Springer Science+Business Media | Naunyn-Schmiedeberg s Archives of Pharmacology
Produção Nacional
Revisado por pares
Mara Cristina Ripoli Meira, Oscar Kenji Nihei, Luiz Eduardo Moschini, Marcos Augusto Moraes Arcoverde, André da Silva Britto, Reinaldo Antônio Silva-Sobrinho, Susana Inés Segura-Muñoz,
Objetivo: analisar a evolução temporal da incidência da dengue e sua correlação com variáveis climáticas em Foz do Iguaçu, um município brasileiro de tríplice fronteira, no período de agosto de 2006 a julho de 2016. Método: estudo descritivo e analítico, realizado em 2018. Foram utilizados dados secundários obtidos dos sistemas de informações em saúde. Utilizou-se análise temporal e foi aplicado teste de regressão linear simples para avaliar a correlação entre as taxas de incidência da dengue e ...
Tópico(s): Viral Infections and Vectors
2021 - UNIVERSIDADE FEDERAL DO PARANÁ | Cogitare Enfermagem