Classified Advertising: CORONER for MIDDLESEX.-The Committee for conducting the Election of WM. BAKER, Esq.,, On the 1st of October will be published, ...
1830 - Gale Group | TDA
Produção Nacional
Revisado por pares
Eliene Putira Sacuema Rodrigues, Isabella Nogueira Abreu, Carlos Neandro Cordeiro Lima, Dennyson Leandro M. Fonseca, Sávio Felipe Gomes Pereira, Laena Costa dos Reis, Izaura Maria Vieira Cayres Vallinoto, João Farias Guerreiro, Antônio Carlos Rosário Vallinoto,
Abstract The COVID-19 pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) reached the Brazilian Amazon and spread among indigenous populations. In the present study, we demonstrate a high prevalence of infection among the Xikrin of Bacajá people (Kayapó). A sample of 100 individuals of both sexes (51 men and 49 women) with ages ranging from 2 to 82 years were clinically evaluated and tested for the presence of anti-SARS-CoV-2 IgG antibody. Among all investigated individuals, ...
Tópico(s): Mosquito-borne diseases and control
2021 - BioMed Central | International Journal for Equity in Health
Paulo Ventura, Tânia Fernandes, Alexandre Pereira, José C. Guerreiro, António Farinha‐Fernandes, João Delgado, Miguel F. Ferreira, Bruno Faustino, Isabel María Raposo, Alan C.‐N. Wong,
Holistic processing of visual words (i.e., obligatory encoding of/attending to all letters of a word) could be a marker of expert word recognition. In the present study, we thus examined for the first time whether there is a direct relation between the word-composite effect (i.e., all parts of a visual word are fully processed when observers perform a task on a word part) and fast access to the orthographic lexicon by visual word experts (i.e., fluent adult readers). We adopted an individual differences ...
Tópico(s): Visual and Cognitive Learning Processes
2020 - Springer Science+Business Media | Attention Perception & Psychophysics
Labib AL‐Musawe, Carla Torre, José Guerreiro, António Teixeira Rodrigues, João Filipe Raposo, Hélder Mota‐Filipe, Ana Paula Martins,
Abstract The aim of the study is to investigate the patterns of polypharmacy, clinical‐relevant drug‐drug interactions (DDIs), and potentially inappropriate medicines (PIMs), and whether polypharmacy, potential serious clinically‐relevant DDIs, or PIMs can be associated with low quality of life (QoL) index scores of older adults with type 2 diabetes (T2D). A cross‐sectional study was conducted using data of 670 elderly T2D sub‐cohort from a nationwide pharmacy‐based intensive monitoring study of inception ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2020 - Wiley | Pharmacology Research & Perspectives
Produção Nacional
Revisado por pares
Ricardo Ishak, Marluísa de Oliveira Guimarães Ishak, Vânia Nakauth Azevedo, Luiz Fernando Almeida Machado, Izaura Maria Cayres Vallinoto, Maria Alice Freitas Queiroz, Greice de Lemos Cardoso Costa, João Farias Guerreiro, Antônio Carlos Rosário Vallinoto,
Abstract The description of the first human retrovirus, human T-lymphotropic virus 1 (HTLV-1), was soon associated with an aggressive lymphoma and a chronic inflammatory neurodegenerative disease. Later, other associated clinical manifestations were described, affecting diverse target organs in the human body and showing the enormous burden carried by the virus and the associated diseases. The epidemiology of HTLV-1 and HTLV-2 showed that they were largely distributed around the world, although it ...
Tópico(s): Animal Disease Management and Epidemiology
2020 - University of Oxford | Virus Evolution
Sebastián Giulianelli, Marina Riggio, Tomás Guillardoy, Cecilia Pérez Piñero, María A. Gorostiaga, Gonzalo R. Sequeira, Gabriela Pataccini, María F. Abascal, Maria Fernanda Pessatti de Toledo, Britta M. Jacobsen, Ana C. L. Guerreiro, António S. Barros, Virginia Novaro, Fátima Liliana Monteiro, Francisco Amado, Hugo Gass, Martı́n C. Abba, Luísa A. Helguero, Claudia Lanari,
Progression to hormone‐independent growth leading to endocrine therapy resistance occurs in a high proportion of patients with estrogen receptor alpha (ERα) and progesterone receptors (PR) positive breast cancer. We and others have previously shown that estrogen‐ and progestin‐induced tumor growth requires ERα and PR interaction at their target genes. Here, we show that fibroblast growth factor 2 (FGF2)‐induces cell proliferation and tumor growth through hormone‐independent ERα and PR activation and ...
Tópico(s): Estrogen and related hormone effects
2019 - Wiley | International Journal of Cancer
Produção Nacional
Revisado por pares
Isabel Luís Jocene Braço, Keyla Santos Guedes de Sá, Mishelle Waqasi, Maria Alice Freitas Queiroz, Andrea Nazaré Rangel da Silva, Izaura Maria Vieira Cayres Vallinoto, Sandra Souza Lima, Marluísa de Oliveira Guimarães Ishak, Ricardo Ishak, João Farias Guerreiro, Antônio Carlos Rosário Vallinoto,
Studies have shown that the human T-lymphotropic virus 2 (HTLV-2) is endemic in several indigenous populations of the Brazilian Amazon and molecular analyses have shown the exclusive presence of HTLV-2 subtype 2c among the indigenous groups of this geographical region. The present study characterizes the prevalence of HTLV-2 infection in three new villages of the Xikrin tribe, in the Kayapo group, according to their distribution by sex and age. The study included 263 samples from individuals from ...
Tópico(s): Vector-Borne Animal Diseases
2019 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Lis Lobo, Lília I. L. Cabral, Maria Inês Sena, Bruno Guerreiro, António Sebastião Rodrigues, Valter Ferreira de Andrade‐Neto, Maria L. S. Cristiano, Fátima Nogueira,
The emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapy in Southeast Asia prompted the need to develop new endoperoxide-type drugs.A chemically diverse library of endoperoxides was designed and synthesized. The compounds were screened for in vitro and in vivo anti-malarial activity using, respectively, the SYBR Green I assay and a mouse model. Ring survival and mature stage survival assays were performed against artemisinin-resistant and artemisinin- ...
Tópico(s): Phenothiazines and Benzothiazines Synthesis and Activities
2018 - BioMed Central | Malaria Journal
Diogo Alpuim Costa, Tiago Costa, E. Netto, Natércia Joaquim, Isabel Ventura, Ana Cristina Pratas, P. Winckler, Inês Pires da Silva, Ana Catarina Pinho, I. Sargento, Francisco Guerreiro, António Moreira,
Abstract Over the last decades, several therapeutic options were considered in the treatment of the osteoradionecrosis (ORN) of the mandible, including supportive measures, ultrasound therapy, corticosteroids, hyperbaric oxygen, surgical resection with reconstruction, and, more recently, drugs capable of reversing the fibroatrophic process. Once established, the ORN does not spontaneously disappear and a standard treatment has not yet been defined. The clear clinical effectiveness of hyperbaric oxygen ...
Tópico(s): Oral Health Pathology and Treatment
2016 - Wiley | Head & Neck
... Viana, Cintia Pereira de Souza, Renato de Carvalho Guerreiro, Fabian Antonio Slama, and Eduardo da Matta Mello Portugal1 May ...
Tópico(s): Meta-analysis and systematic reviews
2009 - American Physiological Society | Journal of Applied Physiology
... Viana, Cintia Pereira de Souza, Renato de Carvalho Guerreiro, Fabian Antonio Slama, and Eduardo da Matta Mello Portugal1 May ...
Tópico(s): Mitochondrial Function and Pathology
2000 - American Physiological Society | Journal of Applied Physiology
Doris Vela, María Pilar García Guerreiro, Antonio Fontdevila,
An adapted amplified fragment length polymorphism (AFLP) protocol is presented for detection of hybrid instability in the genome of interspecific hybrids between Drosophila buzzatii and D. koepferae species. Analyses of 15 AFLP instability markers (new bands detected in hybrids) show that up to 81% are the result of transposable element (TE) activity. Twenty TEs associated with AFLP instability markers have been detected by this method in backcross hybrids and segmental hybrids, demonstrating its validity ...
Tópico(s): Genomics and Phylogenetic Studies
2011 - Future Science Ltd | BioTechniques
Sabrina Di Masi, Marco Costa, Francesco Canfarotta, António Guerreiro, A. M. Hartley, Sergey A. Piletsky, Cosimino Malitesta,
A high-performance impedimetric sensing platform was designed to detect proteins by employing molecularly imprinted polymeric nanoparticles (nanoMIPs) as selective receptors. This was achieved
Tópico(s): Pharmacological Effects and Assays
2023 - Royal Society of Chemistry | Analytical Methods
Joana Areias-Guerreiro, António Mira, A. Márcia Barbosa,
Species distribution and ecological niche models are increasingly used in biodiversity management and conservation. However, one thing that is important but rarely done is to follow up on the predictive performance of these models over time, to check if their predictions are fulfilled and maintain accuracy, or if they apply only to the set in which they were produced. In 2003, a distribution model of the Eurasian otter ( Lutra lutra ) in Spain was published, based on the results of a country-wide ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2016 - Associazione Teriologica Italiana | Hystrix
María Pilar García Guerreiro, Antonio Fontdevila,
Transposable elements (TEs) constitute an important source of genetic variability owing to their jumping and regulatory properties, and are considered to drive species evolution. Several factors that are able to induce TE transposition in genomes have been documented (for example environmental stress and inter- and intra-specific crosses) but in many instances the reasons for TE mobilisation have yet to be elucidated. Colonising populations constitute an ideal model for studying TE behaviour and distribution ...
Tópico(s): Nematode management and characterization studies
2011 - Springer Science+Business Media | BMC Evolutionary Biology
... Viana, Cintia Pereira de Souza, Renato de Carvalho Guerreiro, Fabian Antonio Slama, and Eduardo da Matta Mello Portugal1 May ...
Tópico(s): Academic Publishing and Open Access
2011 - American Physiological Society | Journal of Applied Physiology
Produção Nacional
Revisado por pares
Marcela Aparecida Guerreiro Machado, Antônio Fernando Branco Costa,
AbstractThe steady-state average run length (ARL) is a function of the in-control probabilities of being in each nonabsorbing state. Davis and Woodall (2002) tabulated values that are significantly smaller than the steady-state ARLs, because they used the out-of-control probabilities. The synthetic chart signals when a second sample point falls beyond the control limits, no matter whether one of them falls above the centerline and the other falls below it. The side-sensitive version of the synthetic ...
Tópico(s): Advanced Statistical Methods and Models
2014 - Taylor & Francis | Communication in Statistics- Theory and Methods
Produção Nacional
Revisado por pares
Marcela Aparecida Guerreiro Machado, Antônio Fernando Branco Costa,
The synthetic chart combined with an chart (Synthetic- chart) signals when a sample point falls beyond the control limits or when a second point, not far from the first one, falls beyond the warning limits, no matter whether one of them falls above the centreline and the other falls below. The side-sensitive Synthetic- chart (SS Synthetic- chart) does not signal when the points beyond the warning limits are on opposite sides of the centreline. In this article, we show that the performance of the Synthetic- ...
Tópico(s): Advanced Statistical Methods and Models
2014 - Taylor & Francis | International Journal of Production Research
Produção Nacional
Revisado por pares
Alexandra Bottcher, Igor Cesarino, Adriana Brombini dos Santos, Renato Vicentini, Juliana Lischka Sampaio Mayer, Ruben Vanholme, Kris Morreel, Geert Goeminne, J. C. M. S. Moura, Paula Macedo Nóbile, Sandra Maria Carmello-Guerreiro, Ivan Antônio dos Anjos, Silvana Creste, Wout Boerjan, Marcos Guimarães de Andrade Landell, Paulo Mazzafera,
Sugarcane (Saccharum spp.) is currently one of the most efficient crops in the production of first-generation biofuels. However, the bagasse represents an additional abundant lignocellulosic resource that has the potential to increase the ethanol production per plant. To achieve a more efficient conversion of bagasse into ethanol, a better understanding of the main factors affecting biomass recalcitrance is needed. Because several studies have shown a negative effect of lignin on saccharification ...
Tópico(s): Lignin and Wood Chemistry
2013 - Oxford University Press | PLANT PHYSIOLOGY
Friederike Lüpke, Kristine Stenzel, Flora Dias Cabalzar, Thiago Costa Chacon, Aline da Cruz, Bruna Franchetto, António Guerreiro, Sérgio Meira, Glauber Romling da Silva, Wilson Silva, Luciana Storto, Leonor Valentino, Hein van der Voort, Rachel Watson,
This article explores and compares multilingualism in small-scale societies of Western Africa and Lowland South America. All are characterized by complex and extensive multilingual practices and regional exchange systems established before the onset of globalization and its varying impacts. Through overviews of the general historical and organizational features of regions, vignette case studies, and a discussion of transformative processes affecting them, we show that small-scale multilingual societies ...
Tópico(s): EFL/ESL Teaching and Learning
2020 - | Anthropological linguistics
Produção Nacional
Revisado por pares
Joana F. Guerreiro, Marco Antônio G. B. Gomes, Francesca Pagliari, Jeannette Jansen, Maria Grazia Marafioti, Clelia Nisticò, Rachel Hanley, Rafael O. Costa, Sarah S. Ferreira, Filipa Mendes, Christiane Fernandes, Adolfo Horn, Luca Tirinato, Joao Seco,
Gliomas are the most common type of primary brain tumors, presenting high mortality and recurrence rates that highlight the need for the development of more efficient therapies. In that context, we investigated iron(iii) (FeL) and copper(ii) (CuL) complexes containing the tetradentate ligand 2-{[(3-chloro-2-hydroxy-propyl)-pyridin-2-ylmethyl-amino]-methyl}-phenol (L) as potential antimetastatic compounds in glioma cells. These complexes were designed to act as mimetics of antioxidant metalloenzymes ( ...
Tópico(s): Redox biology and oxidative stress
2020 - Royal Society of Chemistry | RSC Advances
Arnab Guha, Omar Sheej Ahmad, António Guerreiro, Kal Karim, Niklas Sandström, Victor P. Ostanin, Wouter van der Wijngaart, Sergey A. Piletsky, Sourav K. Ghosh,
Small molecule detection is of wide interest in clinical and industrial applications. However, its accessibility is still limited as miniaturisation and system integration is challenged in reliability, costs and complexity. Here we combined a 14.3 MHz quartz crystal resonator (QCR), actuated and analysed using a fixed frequency drive (FFD) method, with a nanomolecular imprinted polymer for label-free, realtime detection of N-hexanoyl-L-homoserine lactone (199 Da), a gram-negative bacterial infection ...
Tópico(s): Advanced Biosensing Techniques and Applications
2020 - Elsevier BV | Biosensors and Bioelectronics
Ewa Moczko, António Guerreiro, César Cáceres, Elena Piletska, Börje Sellergren, Sergey A. Piletsky,
Tópico(s): Protein purification and stability
2019 - Elsevier BV | Journal of Chromatography B
Sabrina Di Masi, Antonio Pennetta, António Guerreiro, Francesco Canfarotta, Giuseppe Egidio De Benedetto, Cosimino Malitesta,
Herein we report the fabrication, characterisation and application of a novel voltammetric sensor based on an electrosynthesised ion imprinted polymer (IIP) film for the determination of copper(II) in water samples. This sensitive and highly selective sensor was prepared by electropolymerisation of p-phenylenediamine in the presence of Cu2+ as template, combined with the screen-printed technology for the transducer element. Electrochemical methods were used to control the electropolymerisation process, ...
Tópico(s): Analytical Chemistry and Sensors
2019 - Elsevier BV | Sensors and Actuators B Chemical
Francesco Canfarotta, Larissa Lezina, António Guerreiro, Joanna Czulak, Alexey Petukhov, Alexandra Daks, Katarzyna Smolinska‐Kempisty, Alessandro Poma, Sergey A. Piletsky, Nikolai A. Barlev,
Epidermal growth factor receptor (EGFR), a tyrosine kinase receptor, is over-expressed in many tumors, including almost half of triple-negative breast cancers. The latter belong to a very-aggressive and drug-resistant form of malignancy. Although humanized anti-EGFR antibodies can work efficiently against these cancers both as monotherapy and in combination with genotoxic drugs, instability and high production costs are some of their known drawbacks in clinical use. In addition, the development of ...
Tópico(s): Analytical chemistry methods development
2018 - American Chemical Society | Nano Letters
Francesco Canfarotta, Joanna Czulak, António Guerreiro, Álvaro García‐Cruz, Sergey A. Piletsky, Gizem Ertürk, Martin Hedström, Bo Mattìasson,
Molecularly Imprinted Polymers (MIPs) are synthetic receptors capable of selective binding to their target (template) molecules and, hence, are used as recognition elements in assays and sensors as a replacement for relatively unstable enzymes and antibodies. Herein, we describe a manufacturing-friendly protocol for integration of MIP nanoparticles (nanoMIPs) with a (label-free) capacitive sensor. The nanoMIPs were produced by solid-phase synthesis for two templates with different sizes and properties, ...
Tópico(s): Biosensors and Analytical Detection
2018 - Elsevier BV | Biosensors and Bioelectronics
Katarzyna Smolinska‐Kempisty, Omar Sheej Ahmad, António Guerreiro, K A Karim, Elena Piletska, Sergey A. Piletsky,
Here we present a potentiometric sensor for cocaine detection based on molecularly imprinted polymer nanoparticles (nanoMIPs) produced by the solid-phase imprinting method. The composition of polymers with high affinity for cocaine was optimised using molecular modelling. Four compositions were selected and polymers prepared using two protocols: chemical polymerisation in water and UV-initiated polymerisation in organic solvent. All synthesised nanoparticles had very good affinity to cocaine with ...
Tópico(s): Molecular Sensors and Ion Detection
2017 - Elsevier BV | Biosensors and Bioelectronics
Ferdia Bates, Mirko Busato, Elena Piletska, Michael J. Whitcombe, Kal Karim, António Guerreiro, Manel del Valle, Alejandro Giorgetti, Sergey A. Piletsky,
A novel protocol for use of molecularly imprinted polymer (MIP) in analysis of melamine is presented. Design of polymer for melamine has been achieved using a combination of computational techniques and laboratory trials, the former greatly reducing the duration of the latter. The compatibility and concerted effect of monomers and solvents were also investigated and discussed. Two novel open-source tools were presented which are the online polymer calculator from mipdatabase.com and the application ...
Tópico(s): Analytical chemistry methods development
2017 - Taylor & Francis | Separation Science and Technology
Existem conexões entre a literatura e a matemática que têm sido trabalhadas por educadores e professores do ensino básico na resolução de problemas, no estabelecimento de conexões entre as ideias matemáticas, os conceitos e as experiências pessoais dos alunos e no desenvolvimento do pensamento crítico. Apresentam-se dois estudos, um realizado no pré-escolar, em que a investigação mostrou a possibilidade de explorar a matemática através de um texto literário, adequado à idade das crianças, e outro ...
Tópico(s): Linguistics and Education Research
2017 - University of A Coruña | Revista de Estudios e Investigación en Psicología y Educación
Siping Tang, Francesco Canfarotta, Katarzyna Smolinska‐Kempisty, Elena Piletska, António Guerreiro, Sergey A. Piletsky,
In this work, molecularly imprinted nanoparticles are used as direct replacement of antibodies in a pseudo-ELISA format (competitive assay) for detection of gentamicin in spiked milk.
Tópico(s): Analytical chemistry methods development
2017 - Royal Society of Chemistry | Analytical Methods