Sara Toniolo, Anna Mazzi, Giulia Mazzarotto, Antonio Scipioni,
Tópico(s): Life Cycle Costing Analysis
2019 - Springer Science+Business Media | The International Journal of Life Cycle Assessment
Antonio Toniato, Renzo Mazzarotto, Andrea Piotto, Paolo Bernante, C Pagetta, Maria Rosa Pelizzo,
Tópico(s): Voice and Speech Disorders
2004 - Springer Science+Business Media | World Journal of Surgery
Francesco Burzotta, Enrico Romagnoli, Alessandro Manzoli, Christian Pristipino, Flavia Belloni, Gennaro Sardella, Stefano Rigattieri, Gaetano Gioffrè, Pietro Mazzarotto, Francesco Summaria, Antonio Parma, Alessandro Danesi, Francesco Prati, Carlo Trani,
Stent thrombosis (ST) is a recognized complication limiting the clinical efficacy of percutaneous coronary interventions (PCI). Because of the increasing number of stent-based PCI, the absolute number of patients experiencing ST is expected to expand. Re-PCI is the commonly adopted treatment for patients with ST; however, the prognostic variables as well as the angiographic and clinical results have not been systematically assessed. Moreover, the possible benefit associated with the use of adjunctive ...
Tópico(s): Cardiac Imaging and Diagnostics
2007 - Elsevier BV | American Heart Journal
Francesco Mazzarotto, Megan H. Hawley, Matteo Beltrami, Leander Beekman, Antonio de Marvao, Kathryn A. McGurk, Ben Statton, Beatrice Boschi, Francesca Girolami, Angharad M. Roberts, Elisabeth M. Lodder, Mona Allouba, Soha Romeih, Yasmine Aguib, A. John Baksi, Antonis Pantazis, Sanjay Prasad, Elisabetta Cerbai, Magdi H. Yacoub, Declan P. O’Regan, Stuart A. Cook, James S. Ware, Birgit Funke, Iacopo Olivotto, Connie R. Bezzina, Paul J.R. Barton, Roddy Walsh,
PurposeTo characterize the genetic architecture of left ventricular noncompaction (LVNC) and investigate the extent to which it may represent a distinct pathology or a secondary phenotype associated with other cardiac diseases.MethodsWe performed rare variant association analysis with 840 LVNC cases and 125,748 gnomAD population controls, and compared results to similar analyses on dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM).ResultsWe observed substantial genetic overlap indicating ...
Tópico(s): Congenital heart defects research
2021 - Elsevier BV | Genetics in Medicine
Tópico(s): Religious and Theological Studies
2011 - | Anais do ... Congresso Internacional de História/Anais do Congresso Internacional de História
Peter Bartenstein, Elisa Caballero Calabuig, C.L. Maini, Renzo Mazzarotto, M.A. Muros de Fuentes, T. Petrich, Fernando Rodrigues, Juan Antonio Vallejo Casas, Federica Vianello, Michela Basso, Marcelino Gómez Balaguer, Alexander Haug, Fabio Monari, R. Sánchez-Vañó, Rosa Sciuto, James A. Magner,
Few data exist on using thyrotropin alfa (recombinant human thyroid-stimulating hormone [rhTSH]) with radioiodine for thyroid remnant ablation of patients who have T4 primary tumors (invasion beyond the thyroid capsule).A retrospective chart review protocol at nine centers in Europe was set up with special waiver of need for informed consent, along with a careful procedure to avoid selection bias when enrolling patients into the database. Data on 144 eligible patients with T4 tumors were collected ( ...
Tópico(s): Thyroid Disorders and Treatments
2013 - Mary Ann Liebert, Inc. | Thyroid
Produção Nacional
Revisado por pares
Xiaolei Zhang, Roddy Walsh, Nicola Whiffin, Rachel Buchan, William Midwinter, Alicja Wilk, Risha Govind, Nicholas Li, Mian Ahmad, Francesco Mazzarotto, Angharad M. Roberts, Pantazis Theotokis, Erica Mazaika, Mona Allouba, Antonio de Marvao, Chee Jian Pua, Sharlene M. Day, Euan A. Ashley, Steven D. Colan, Michelle Michels, Alexandre C. Pereira, Daniel Jacoby, Carolyn Y. Ho, Iacopo Olivotto, Gunnar Gunnarsson, John L. Jefferies, Chris Semsarian, Jodie Ingles, Declan P. O’Regan, Yasmine Aguib, Magdi H. Yacoub, Stuart A. Cook, Paul J.R. Barton, Leonardo Bottolo, James S. Ware,
PurposeAccurate discrimination of benign and pathogenic rare variation remains a priority for clinical genome interpretation. State-of-the-art machine learning variant prioritization tools are imprecise and ignore important parameters defining gene–disease relationships, e.g., distinct consequences of gain-of-function versus loss-of-function variants. We hypothesized that incorporating disease-specific information would improve tool performance.MethodsWe developed a disease-specific variant classifier, ...
Tópico(s): Genetic Neurodegenerative Diseases
2020 - Elsevier BV | Genetics in Medicine
Antonio Toniato, Isabella Merante Boschin, Dario Casara, Renzo Mazzarotto, Domenico Rubello, Mariarosa Pelizzo,
Tópico(s): Thyroid and Parathyroid Surgery
2008 - Springer Science+Business Media | Annals of Surgical Oncology
Roberto Iacovelli, Chiara Ciccarese, Emilio Bria, Mario Romano, Emanuela Fantinel, Davide Bimbatti, A. Muraglia, Antonio Benito Porcaro, Salvatore Siracusano, Matteo Brunelli, Renzo Mazzarotto, Walter Artibani, Giampaolo Tortora,
Introduction The cardiovascular toxicity related to abiraterone and enzalutamide has been previously studied by our group. In this analysis, we aim to update our previous findings related to abiraterone and enzalutamide, including the new available evidence, both in castration-resistant and hormone-sensitive prostate cancer. Patients and Methods Prospective studies were identified by searching the MEDLINE/PubMed, Cochrane Library, and ASCO Meeting abstracts. Combined relative risks (RRs) and 95% ...
Tópico(s): Hormonal and reproductive studies
2017 - Elsevier BV | Clinical Genitourinary Cancer
Francesco Mazzarotto, Upasana Tayal, Rachel Buchan, William Midwinter, Alicja Wilk, Nicola Whiffin, Risha Govind, Erica Mazaika, Antonio de Marvao, Timothy J. W. Dawes, Leanne E. Felkin, Mian Ahmad, Pantazis Theotokis, Elizabeth Edwards, Alexander Ing, Kate Thomson, Laura Chan, David Sim, A. John Baksi, Antonis Pantazis, Angharad M. Roberts, Hugh Watkins, Birgit Funke, Declan P. O’Regan, Iacopo Olivotto, Paul J.R. Barton, Sanjay Prasad, Stuart A. Cook, James S. Ware, Roddy Walsh,
Background: Dilated cardiomyopathy (DCM) is genetically heterogeneous, with >100 purported disease genes tested in clinical laboratories. However, many genes were originally identified based on candidate-gene studies that did not adequately account for background population variation. Here we define the frequency of rare variation in 2538 patients with DCM across protein-coding regions of 56 commonly tested genes and compare this to both 912 confirmed healthy controls and a reference population of ...
Tópico(s): Williams Syndrome Research
2020 - Lippincott Williams & Wilkins | Circulation
Davide Bimbatti, Chiara Ciccarese, Emanuela Fantinel, Teodoro Sava, Francesco Massari, Iolanda Bisogno, Mario Romano, Antonio Benito Porcaro, Matteo Brunelli, Guido Martignoni, Renzo Mazzarotto, Walter Artibani, Giampaolo Tortora, Roberto Iacovelli,
Despite important results achieved for metastatic renal cell carcinoma, some patients could benefit from local treatments or an initial active surveillance (AS) period for recurrent disease. We aim to analyze: changes in the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk class, the number of metastases and the disease burden from the start of AS to the beginning of systemic therapy; and if these changes influenced patient outcomes. Patients who started AS at our institution ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2018 - Elsevier BV | Urologic Oncology Seminars and Original Investigations
Produção Nacional
... Grossa, estado do Paraná. Esta autoridade foi D. Antonio Mazzarotto nomeado primeiro bispo para a recém-criada diocese de Ponta Grossa. D. Antonio, desenvolveu um trabalho de acolhimento, alerta e cuidado ...
Tópico(s): Migration, Racism, and Human Rights
2016 - UNIVERSIDADE FEDERAL DO PARANÁ | Revista Relegens Thréskeia
H. Koussis, A. Scola, S. Tonello, B Busnardo, Martin Donach, Mariarosa Pelizzo, Antonio Toniato, E. Mazzarotto, E. Mazzarotto, P. Karahontzitis, S. Monfardini,
5571 Background: To investigate the role of multimodality treatment in patients with ATC. Methods: From 1992 to 2005, 56 patients with a histologically or cytologically proven ATC were referred to the Thyroid Centre of Padua University General Hospital. There were 36 females and 20 males, median age 69 years (range 27–90). About one-third of patients had a history of prior nodular goitre. Aggressive local disease was present in 30 patients, distant metastases, mainly to the lung, were present in ...
Tópico(s): Thyroid Cancer Diagnosis and Treatment
2006 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
D. Antonio Mazzarotto was the first bishop of the Diocese of Ponta Grossa-PR whose episcopate lasted between 1965 and ...
Tópico(s): Urban Development and Societal Issues
2014 - University of Toronto Press | Mouseion Journal of the Classical Association of Canada
Produção Nacional
: D. Antonio Mazzarotto (1890-1980) foi o primeiro bispo da Diocese de Ponta Grossa, Parana. Construiu, desde a epoca de ...
Tópico(s): Migration, Racism, and Human Rights
2013 - National History Association | Revista Brasileira de História das Religiões
Produção Nacional
Revisado por pares
Zíngara Rocio Santos Eurich, Sílvia Méri Carvalho,
... Manuel Ribas, praça Barão do Rio Branco, Bispo Antônio Mazzarotto e Simão Bolivar, foram as praças com mais ...
Tópico(s): Urban Arborization and Environmental Studies
2015 - UNIVERSIDADE FEDERAL DO PARANÁ | Revista da Sociedade Brasileira de Arborização Urbana
Rosângela Wosiack Zulian, Ricardo Enguel Gonçalves,
... várias dioceses do Brasil. Em Ponta Grossa, D. Antonio Mazzarotto envidou esforços nas ações da L.E.C, ...
Tópico(s): Religion and Society in Latin America
2024 - FUNDAÇÃO GETÚLIO VARGAS | Mosaico
Marco Valgimigli, Enrico Frigoli, Sergio Leonardi, Pascal Vranckx, Martina Rothenbühler, Matteo Tebaldi, Ferdinando Varbella, Paolo Calabró, Stefano Garducci, Paolo Rubartelli, Carlo Briguori, Giuseppe Andò, Maurizio Ferrario, Ugo Limbruno, Roberto Garbo, Paolo Sganzerla, Filippo Russo, Marco Stefano Nazzaro, Alessandro Lupi, Bernardo Cortese, Arturo Ausiello, Salvatore Ierna, Giovanni Esposito, Giuseppe Ferrante, Andrea Santarelli, Gennaro Sardella, Nicoletta De Cesare, Paolo Tosi, Arnoud W.J. van ‘t Hof, Elmir Ömerovic, Salvatore Brugaletta, Stephan Windecker, Dik Heg, Peter Jüni, Gianluca Campo, Lucia Uguccioni, Corrado Tamburino, Patrizia Presbitero, Dennis Zavalloni-Parenti, Fabio Ferrari, Roberto Ceravolo, Fabio Tarantino, Giampaolo Pasquetto, Gavino Casu, Stefano Mameli, Maria Letizia Stochino, Pietro Mazzarotto, Alberto Cremonesi, Francesco Saia, Giovanni Saccone, Fabio Abate, Andrea Picchi, Roberto Violini, Salvatore Colangelo, Giacomo Boccuzzi, Vincenzo Guiducci, Carlo Vigna, Antonio Zingarelli, Andrea Gagnor, Tiziana Zaro, Simone Tresoldi, Pietro Vandoni, Marco Contarini, Armando Liso, Antonio Dellavalle, Salvatore Curello, Fabio Mangiacapra, Rosario Evola, Cataldo Palmieri, Camillo Falcone, Francesco Liïstro, Manuela Creaco, Antonio Colombo, Alaide Chieffo, Andrea Perkan, Stefano De Servi, Dionigi Fischetti, Stefano Rigattieri, Alessandro Sciahbasi, Edoardo Pucci, Enrico Romagnoli, Claudio Moretti, Luciano Moretti, Raffaele De Caterina, Massimo Caputo, Marco Zimmarino, Ezio Bramucci, Emilio Di Lorenzo, Maurizio Turturo, Roberto Bonmassari, Carlo Penzo, Bruno Loi, Ciro Mauro, Anna Sonia Petronio, Gabriele Gabrielli, Antonio Micari, Flavia Belloni, Francesco Amico, Marco Comeglio, Claudio Fresco, Isala Klinieken, Nicolas M. Van Mieghem, Roberto Diletti, Evelyn Regar, Manel Sabaté, Joan Antoni Gómez Hospital, José Francisco Díaz Fernández, Vicente Mainar, José M. de la Torre Hernández,
The Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox (MATRIX) programme was designed to assess the comparative safety and effectiveness of radial versus femoral access and of bivalirudin versus unfractionated heparin with optional glycoprotein IIb/IIIa inhibitors in patients with the whole spectrum of acute coronary syndrome undergoing invasive management. Here we describe the prespecified final 1-year outcomes of the entire programme.MATRIX ...
Tópico(s): Vascular Procedures and Complications
2018 - Elsevier BV | The Lancet
Giuseppe Andò, Bernardo Cortese, Filippo Russo, Martina Rothenbühler, Enrico Frigoli, Giuseppe Gargiulo, Carlo Briguori, Pascal Vranckx, Sergio Leonardi, Vincenzo Guiducci, Flavia Belloni, Fabio Ferrari, José M. de la Torre Hernández, Salvatore Curello, Francesco Liïstro, Andrea Perkan, Stefano De Servi, Gavino Casu, Antonio Dellavalle, Dionigi Fischetti, Antonio Micari, Bruno Loi, Fabio Mangiacapra, Nunzio Russo, Fabio Tarantino, Francesco Saia, Dik Heg, Stephan Windecker, Peter Jüni, Marco Valgimigli, Maria Salomone, Enrico Frigoli, Pierpaolo Occhilupo, Veronica Lodolini, Monia Monti, Maria Grazia Mazzone, Erika Delos, Maria Teresa Caruso, Maggie Testa, Nestor Ciociano, Maurizio Lazzero, Davide Gazzotti, Lorenzo Cagliari, Leila Shahmohammadi, Martina Caiazza, Vittorio Virga, Elena Guerra, E Michalska, S Castellini, Vincenzo Serino, Gabriella Visconti, Gianluca Pendenza, Monica Portolan, Marco Anzini, Elisa Silvetti, Tiziana Coco, Francesco Costa, Sara Ariotti, Linda Valli, Marianna Adamo, Marcello Marino, Pascal Vranckx, Sergio Leonardi, Pierluigi Tricoci, Peter Jüni, Martina Rothenbühler, Dik Heg, Marco Valgimigli, Andrea Gagnor, Paolo Calabró, Paolo Rubartelli, Stefano Garducci, Giuseppe Andò, Andrea Santarelli, Mario Galli, Roberto Garbo, Ezio Bramucci, Salvatore Ierna, Carlo Briguori, Bernardo Cortese, Ugo Limbruno, Roberto Violini, Patrizia Presbitero, Nicoletta De Cesare, Paolo Sganzerla, Arturo Ausiello, Paolo Tosi, Gennaro Sardella, Manel Sabaté, Salvatore Brugaletta, Giovanni Saccone, Pietro Vandoni, Antonio Zingarelli, Armando Liso, Stefano Rigattieri, Emilio Di Lorenzo, Carlo Vigna, Cataldo Palmieri, Camillo Falcone, Raffaele De Caterina, Massimo Caputo, Giovanni Esposito, Alessandro Lupi, Pietro Mazzarotto, F Varbella, Tiziana Zaro, Marco Stefano Nazzaro, Sunil V. Rao, Arnoud W.J. van ‘t Hof, Elmir Ömerovic, Paolo Calabró, Arnoud W.J. van ‘t Hof, Manel Sabaté, Salvatore Brugaletta, Elmir Ömerovic, Gianluca Campo, Marco Valgimigli, Lucia Uguccioni, Corrado Tamburino, Patrizia Presbitero, Dennis Zavalloni-Parenti, Fabio Ferrari, Roberto Ceravolo, Andrea Santarelli, Fabio Tarantino, Paolo Calabró, Giampaolo Pasquetto, Giovanni Esposito, Salvatore Ierna, Gavino Casu, Stefano Mameli, Maria Letizia Stochino, Nicoletta De Cesare, Pietro Mazzarotto, Alberto Cremonesi, Francesco Saia, Giovanni Saccone, Fabio Abate, Ugo Limbruno, Andrea Picchi, Roberto Violini, Marco Stefano Nazzaro, Roberto Garbo, Salvatore Colangelo, Giacomo Boccuzzi, Paolo Tosi, Vincenzo Guiducci, Carlo Vigna, Antonio Zingarelli, Andrea Gagnor, Ferdinando Varbella, Stefano Garducci, Tiziana Zaro, Stefano Tresoldi, Pietro Vandoni, Marco Contarini, Armando Liso, Antonio Dellavalle, Salvatore Curello, Fabio Mangiacapra, Paolo Rubartelli, Rosario Evola, Giuseppe Andò, Cataldo Palmieri, Camillo Falcone, Francesco Liïstro, Manuela Creaco, Antonio Colombo, Alaide Chieffo, Andrea Perkan, Stefano De Servi, Dionigi Fischetti, Stefano Rigattieri, Alessandro Sciahbasi, Edoardo Pucci, Enrico Romagnoli, Claudio Moretti, Luciano Moretti, Raffaele De Caterina, Massimo Caputo, Marco Zimmarino, Paolo Sganzerla, Maurizio Ferrario, Ezio Bramucci, Emilio Di Lorenzo, Carlo Briguori, Maurizio Turturo, Roberto Bonmassari, Carlo Penzo, Bruno Loi, Ciro Mauro, Arturo Ausiello, Anna Sonia Petronio, Gabriele Gabrielli, Gennaro Sardella, Antonio Micari, Flavia Belloni, Alessandro Lupi, Francesco Amico, Marco Comeglio, Claudio Fresco, Arnoud W.J. van ‘t Hof, Nicolas M. Van Mieghem, Roberto Diletti, Evelyn Regar, Elmir Ömerovic, Salvatore Brugaletta, Manel Sabaté, Joan Antoni Gómez Hospital, José Francisco Díaz Fernández, Vicente Mainar, José M. de la Torre Hernández,
It remains unclear whether radial access (RA), compared with femoral access (FA), mitigates the risk of acute kidney injury (AKI). The authors assessed the incidence of AKI in patients with acute coronary syndrome (ACS) enrolled in the MATRIX-Access (Minimizing Adverse Haemorrhagic Events by Transradial Access Site and Systemic Implementation of Angiox) trial. Among 8,404 patients, 194 (2.3%) were excluded due to missing creatinine values, no or an incomplete coronary angiogram, or previous dialysis. ...
Tópico(s): Acute Kidney Injury Research
2017 - Elsevier BV | Journal of the American College of Cardiology
Produção Nacional
Revisado por pares
Roddy Walsh, Francesco Mazzarotto, Nicola Whiffin, Rachel Buchan, William Midwinter, Alicja Wilk, Nicholas Li, Leanne E. Felkin, Nathan Ingold, Risha Govind, Mian Ahmad, Erica Mazaika, Mona Allouba, Xiaolei Zhang, Antonio de Marvao, Sharlene M. Day, Euan A. Ashley, Steven D. Colan, Michelle Michels, Alexandre C. Pereira, Daniel Jacoby, Carolyn Y. Ho, Kate Thomson, Hugh Watkins, Paul J.R. Barton, Iacopo Olivotto, Stuart A. Cook, James S. Ware,
International guidelines for variant interpretation in Mendelian disease set stringent criteria to report a variant as (likely) pathogenic, prioritising control of false-positive rate over test sensitivity and diagnostic yield. Genetic testing is also more likely informative in individuals with well-characterised variants from extensively studied European-ancestry populations. Inherited cardiomyopathies are relatively common Mendelian diseases that allow empirical calibration and assessment of this ...
Tópico(s): Cardiovascular Function and Risk Factors
2019 - BioMed Central | Genome Medicine
Gianmarco Arabia, Maria Giulia Bellicini, Angelica Cersosimo, Maurizio Memo, Francesco Mazzarotto, Riccardo M. Inciardi, Manuel Cerini, Lin Y. Chen, Mohamed Aboelhassan, Patrizia Benzoni, Gianfranco Mitacchione, Luca Bontempi, Antonio Curnis,
Abstract Background Atrial fibrillation (AF) is a common heart rhythm disorder that is associated with an increased risk of stroke and heart failure (HF). Initially, an association between AF and ion channel dysfunction was identified, classifying the pathology as a predominantly electrical disease. More recently it has been recognized that fibrosis and structural atrial remodeling play a driving role in the development of this arrhythmia also in these cases. Purpose Understanding the role of fibrosis ...
Tópico(s): Cardiac Arrhythmias and Treatments
2024 - Wiley | Pacing and Clinical Electrophysiology
Francesco Burzotta, Antonio Parma, C. Pristipino, Alessandro Manzoli, Flavia Belloni, Gennaro Sardella, Stefano Rigattieri, Alessandro Danesi, Pietro Mazzarotto, Francesco Summaria, Enrico Romagnoli, Francesco Prati, Carlo Trani, Filippo Crea,
Stent thrombosis (ST) is a major complication of percutaneous coronary interventions (PCIs). An invasive management by re-PCI is the commonly adopted treatment for ST, but data on outcome are limited. We performed a 2-year multicentre registry enrolling consecutive patients with angiographically confirmed ST undergoing PCI. The primary angiographic endpoint was optimal angiographic reperfusion (TIMI 3 + blush grade 2 or 3). The primary clinical endpoints were death and major adverse coronary and cerebrovascular ...
Tópico(s): Cardiac Imaging and Diagnostics
2008 - Oxford University Press | European Heart Journal
Giuseppe Gargiulo, Bruno R. da Costa, Enrico Frigoli, Cataldo Palmieri, Marco Stefano Nazzaro, Camillo Falcone, Armando Liso, Carlo Vigna, Fabio Abate, Marco Comeglio, Roberto Diletti, Gabriele Gabrielli, Emilio Di Lorenzo, Pietro Mazzarotto, Marco Zimarino, Claudio Moretti, Antonio Colombo, Carlo Penzo, Giampaolo Pasquetto, Salvatore Brugaletta, Fabio Ferrari, Gavino Casu, Vincenzo Guiducci, Antonio Dellavalle, Francesco Liïstro, Ciro Mauro, Arnoud W.J. van ‘t Hof, Elmir Ömerovic, Salvatore Curello, José M. de la Torre Hernández, Stefano De Servi, Flavia Belloni, Stephan Windecker, Marco Valgimigli,
Our aim was to assess whether bivalirudin compared with unfractionated heparin (UFH) is associated with consistent outcomes in males and females with acute coronary syndrome (ACS) undergoing invasive management.In the MATRIX programme, 7,213 patients were randomised to bivalirudin or UFH. Patients in the bivalirudin group were subsequently randomly assigned to receive or not a post-PCI bivalirudin infusion. The 30-day co-primary outcomes were major adverse cardiovascular events (MACE), defined as death, ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2019 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Antonio de Marvao, Kathryn A. McGurk, Sean Zheng, Marjola Thanaj, Wenjia Bai, Jinming Duan, Carlo Biffi, Francesco Mazzarotto, Ben Statton, Timothy J. W. Dawes, Nicoló Savioli, Brian P. Halliday, Xiao Yun Xu, Rachel Buchan, A. John Baksi, Marina Quinlan, Paweł Tokarczuk, Upasana Tayal, Catherine Francis, Nicola Whiffin, Pantazis Theotokis, Xiaolei Zhang, Mikyung Jang, Alaine Berry, Antonis Pantazis, Paul J.R. Barton, Daniel Rueckert, Sanjay Prasad, Roddy Walsh, Carolyn Y. Ho, Stuart A. Cook, James S. Ware, Declan P. O’Regan,
BACKGROUND Hypertrophic cardiomyopathy (HCM) is caused by rare variants in sarcomere-encoding genes, but little is known about the clinical significance of these variants in the general population.OBJECTIVES The goal of this study was to compare lifetime outcomes and cardiovascular phenotypes according to the presence of rare variants in sarcomere-encoding genes among middle-aged adults.METHODS This study analyzed whole exome sequencing and cardiac magnetic resonance imaging in UK Biobank participants ...
Tópico(s): Williams Syndrome Research
2021 - Elsevier BV | Journal of the American College of Cardiology
Pietro Mazzarotto, Paolo Di Renzi, Giovanni Minio Paluello, A Carunchio, Roberto Ricci, Antonio Molisso, Vincenzo Ceci, Ciro Indolfi,
Background The present study aimed to evaluate the diagnostic accuracy of four-slice computed tomography for the detection, localization and patency assessment of metal coronary stents in a general population referred for coronary angiography late after coronary angioplasty. Methods Twenty-four consecutive patients with 34 coronary stents underwent multislice computed tomography within 24 h before a clinically driven coronary angiography performed 245 ± 92 days after coronary stent implantation. For ...
Tópico(s): Advanced MRI Techniques and Applications
2006 - Lippincott Williams & Wilkins | Journal of Cardiovascular Medicine
Angharad M. Roberts, James S. Ware, Daniel S. Herman, Sebastian Schäfer, John Baksi, Alexander G. Bick, Rachel Buchan, Roddy Walsh, Shibu John, Stephen Wilkinson, Francesco Mazzarotto, Leanne E. Felkin, Sungsam Gong, Jacqueline MacArthur, Fiona Cunningham, Jason Flannick, Stacey Gabriel, David Altshuler, Peter S. Macdonald, Matthias Heinig, Anne Keogh, Christopher S. Hayward, Nicholas R. Banner, Dudley J. Pennell, Declan P. O’Regan, Ru San Tan, Antonio de Marvao, Timothy J. W. Dawes, Ankur Gulati, Emma J. Birks, Magdi H. Yacoub, Michaël Radkë, Michael Gotthardt, James Wilson, Christopher J. O’Donnell, Sanjay Prasad, Paul J.R. Barton, Diane Fatkin, Norbert Hübner, Jonathan G. Seidman, Christine E. Seidman, Stuart A. Cook,
Truncating variants of the giant protein titin cause dilated cardiomyopathy when they occur toward the protein’s carboxyl terminus and in highly expressed exons.
Tópico(s): RNA Research and Splicing
2015 - American Association for the Advancement of Science | Science Translational Medicine
Roberto Iacovelli, Chiara Ciccarese, Emanuela Fantinel, Davide Bimbatti, Mario Romano, Antonio Benito Porcaro, Salvatore Siracusano, Renzo Mazzarotto, Walter Artibani, Giampaolo Tortora,
AimImmune checkpoint inhibitors of programmed death-1 (PD-1)/programmed death-ligand 1 (PD-L1) have recently entered in the therapeutic armamentarium of several types of cancer. Besides the survival benefit, the true revolution of these agents is the distinctive toxicity profile. We aim to assess the incidence and relative risk (RR) of renal toxicity (RT) in patients with solid tumors treated with monoclonal antibodies (mAbs) directed against PD-1/PD-L1. MethodsBy searching the MEDLINE/PubMed, Cochrane ...
Tópico(s): Renal cell carcinoma treatment
2017 - SAGE Publishing | Journal of Onco-Nephrology
Rafik Tadros, Catherine Francis, Xiao Yun Xu, Alexa M.C. Vermeer, Andrew R. Harper, Roy Huurman, Ken Kelu Bisabu, Roddy Walsh, Edgar T. Hoorntje, Wouter P. te Rijdt, Rachel Buchan, Hannah G. van Velzen, Marjon A. van Slegtenhorst, Jentien M. Vermeulen, Joost A. Offerhaus, Wenjia Bai, Antonio de Marvao, Najim Lahrouchi, Leander Beekman, Jacco C. Karper, Jan H. Veldink, Elham Kayvanpour, Antonis Pantazis, A. John Baksi, Nicola Whiffin, Francesco Mazzarotto, Geraldine Sloane, Hideaki Suzuki, Deborah Schneider-Luftman, Paul Elliott, Pascale Richard, Flavie Ader, Eric Villard, Peter Lichtner, Thomas Meitinger, Michael W.T. Tanck, J. Peter van Tintelen, Andrew Thain, David McCarty, Robert A. Hegele, Jason D. Roberts, Julie Amyot, Marie‐Pierre Dubé, Julia Cadrin‐Tourigny, Geneviève Giraldeau, Philippe L. L’Allier, Patrick Garceau, Jean‐Claude Tardif, S. Matthijs Boekholdt, R. Thomas Lumbers, Folkert W. Asselbergs, Paul J.R. Barton, Stuart A. Cook, Sanjay Prasad, Declan P. O’Regan, Jolanda van der Velden, Karin J. H. Verweij, Mario Talajic, Guillaume Lettre, Yigal M. Pinto, Benjamin Meder, Philippe Charron, Rudolf A. de Boer, Imke Christiaans, Michelle Michels, Arthur A.M. Wilde, Hugh Watkins, Paul M. Matthews, James S. Ware, Connie R. Bezzina,
The heart muscle diseases hypertrophic (HCM) and dilated (DCM) cardiomyopathies are leading causes of sudden death and heart failure in young, otherwise healthy, individuals. We conducted genome-wide association studies and multi-trait analyses in HCM (1,733 cases), DCM (5,521 cases) and nine left ventricular (LV) traits (19,260 UK Biobank participants with structurally normal hearts). We identified 16 loci associated with HCM, 13 with DCM and 23 with LV traits. We show strong genetic correlations between ...
Tópico(s): Genetic Associations and Epidemiology
2021 - Nature Portfolio | Nature Genetics
Italo Porto, Francesco Burzotta, Antonio Parma, Christian Pristipino, Alessandro Manzoli, Flavia Belloni, Gennaro Sardella, Stefano Rigattieri, Alessandro Danesi, Pietro Mazzarotto, Francesco Summaria, Enrico Romagnoli, Francesco Prati, Carlo Trani, Filippo Crea,
Stent thrombosis is a catastrophic occurrence burdened by a high mortality rate and a tendency to recur. We sought to evaluate the angiographic risk factors for recurrent stent thrombosis (rST) in a subpopulation of 91 Outcome of PCI for stent-ThrombosIs Multicenter STudy (OPTIMIST) patients who underwent quantitative angiographic evaluation by an independent core laboratory. The Academic Research Consortium criteria were used for rST adjudication. A multivariate Cox proportional hazards model was ...
Tópico(s): Acute Myocardial Infarction Research
2010 - Elsevier BV | The American Journal of Cardiology
Sebastian Schäfer, Antonio de Marvao, Eleonora Adami, Lorna R. Fiedler, Benjamin Ng, Ester Khin, Owen J. L. Rackham, Sebastiaan van Heesch, Chee Jian Pua, Kui Miao, Roddy Walsh, Upasana Tayal, Sanjay Prasad, Timothy J. W. Dawes, Nicole S. J. Ko, David Sim, Laura Chan, Calvin Chin, Francesco Mazzarotto, Paul J.R. Barton, Franziska Kreuchwig, Dominique P.V. de Kleijn, Teresa Totman, Carlo Biffi, Nicole Tee, Daniel Rueckert, Valentin Schneider-Lunitz, Allison Faber, Vera Regitz‐Zagrosek, Jonathan G. Seidman, Christine E. Seidman, Wolfgang A. Linke, Jean‐Paul Kovalik, Declan P. O’Regan, James S. Ware, Norbert Hübner, Stuart A. Cook,
Stuart Cook and colleagues study the role of TTN (titin)-truncating variants using a combination of heart physiology experiments in rats and genomic analysis in humans. Their data show that TTN variants are associated with a range of cardiac phenotypes in healthy individuals and in patients with dilated cardiomyopathy. Titin-truncating variants (TTNtv) commonly cause dilated cardiomyopathy (DCM). TTNtv are also encountered in ∼1% of the general population, where they may be silent, perhaps reflecting ...
Tópico(s): RNA Research and Splicing
2016 - Nature Portfolio | Nature Genetics