Giampiero La Rocca, Antonino Di Stefano, Ermanno Eleuteri, Rita Anzalone, Francesca Magno, Simona Corrao, Tiziana Loria, Annamaria Martorana, Claudio Di Gangi, Marilena Colombo, Fabrizio Sansone, Francesco Patanè, Felicia Farina, Mauro Rinaldi, Francesco Cappello, Pantaleo Giannuzzi, Giovanni Zummo,
Tópico(s): Cardiac Ischemia and Reperfusion
2008 - Springer Nature | Basic Research in Cardiology
Francesco Cappello, Anna M. Czarnecka, Giampiero La Rocca, Antonino Di Stefano, Giovanni Zummo, Alberto J.L. Macario,
The molecular chaperones Hsp60 and Hsp10 are, according to recent reports, involved in cancer development and progression. We, for instance, have found that their expression varies with distinctive patterns in different malignancies: they are overexpressed in colorectal, exocervical and prostate carcinogenesis, and colorectal cancer progression, but they are downregulated during bronchial carcinogenesis. There is also evidence showing that Hsp60 and Hsp10 can be used as therapeutic agents, for example ...
Tópico(s): Computational Drug Discovery Methods
2007 - Taylor & Francis | Cancer Biology & Therapy
Rita Anzalone, La Rocca G, Antonino Di Stefano, Francesca Magno, Simona Corrao, Marco Carbone, Tiziana Loria, Lo Iacono M, Ermanno Eleuteri, Marilena Colombo, Francesco Cappello, Felicia Farina, Giovanni Zummo, Pantaleo Giannuzzi,
Endothelial cells are key modulators of diverse physiological processes, and their impaired function is a cause of numerous cardiovascular diseases. Under physiologic condition, the reactive oxygen and nitrogen mediators in endothelia lead to the signal propagation of the initial stimulus, by forming molecules with a longer half-life like hydrogen peroxide. Hydrogen peroxide is the focus of growing attention in endothelial biology, and consequently the enzymes involved in its generation and clearance ...
Tópico(s): Redox biology and oxidative stress
2009 - Frontiers in Bioscience | Frontiers in bioscience
Giovanna Di Pasquale, O. Motto, Antonino Rocca, J.T. Carter, P.T. McGrail, Domenico Acierno,
Thermal, mechanical and morphological measurements of reactive thermoplastic modified epoxy resin are reported. Phase separation occurs during the curing. To a small decrease of the modulus of the final materials a large increase of the toughness of the thermoset is associated, as compared with the neat epoxy resin when cured with an usual curing agent.
Tópico(s): Synthesis and properties of polymers
1997 - Elsevier BV | Polymer
Tianjie Zou, David Gerada, Salvatore La Rocca, Antonino La Rocca, Adam Walker, Gaurang Vakil, Saúl López Arevalo, Zeyuan Xu, Mengmeng Cui, Anuvav Bardalai, Meiqi Wang, R. M. Ram Kumar, Alessandro Marfoli, Krzysztof Paciura, Richard Barden, Emil Ernest, Shaohong Zhu, Naila Qayyum, Alastair McQueen, Fengyu Zhang, Chris Gerada,
Synchronous reluctance (Syn-Rel) machines with embedded permanent magnets (PMs) are research hotspots in variable speed motor drives due to their robust rotor structure and wide constant power speed range (CPSR). In this article, the potential of PM-assisted Syn-Rel machine to be next generation heavy duty traction motor solution has been investigated, with special attention put on one key geometric parameter, i.e., airgap length. Careful machine design and optimization has been conducted based on ...
Tópico(s): Magnetic Bearings and Levitation Dynamics
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industry Applications
Tianjie Zou, David Gerada, Antonino La Rocca, Mohsen Moslemin, Alasdair Cairns, Mengmeng Cui, Anuvav Bardalai, Fengyu Zhang, Chris Gerada,
The rapidly increasing demand on power density levels of electric vehicle (EV) drive systems is pushing the boundaries of traction motor performance. Hairpin windings are becoming a popular option for EV motors due to their reduced dc losses and improved heat dissipation capability when compared to traditional random windings. In this article, a comprehensive design approach of hairpin winding layouts is first presented. The flexibility and limitation of end-winding patterns are thoroughly investigated ...
Tópico(s): Magnetic Properties and Applications
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Transportation Electrification
Alessandro Tozzi, Miriam Sciaccaluga, Vittorio Loffredo, Alfredo Megaro, Ada Ledonne, Antonella Cardinale, Mauro Federici, Laura Bellingacci, Silvia Paciotti, Elena Ferrari, Antonino La Rocca, Alessandro Martini, Nicola Biagio Mercuri, Fabrizio Gardoni, Barbara Picconi, Veronica Ghiglieri, Elvira De Leonibus, Paolo Calabresi,
Abstract Misfolding and aggregation of α-synuclein are specific features of Parkinson’s disease and other neurodegenerative diseases defined as synucleinopathies. Parkinson’s disease progression has been correlated with the formation and extracellular release of α-synuclein aggregates, as well as with their spread from neuron to neuron. Therapeutic interventions in the initial stages of Parkinson’s disease require a clear understanding of the mechanisms by which α-synuclein disrupts the physiological ...
Tópico(s): Neurological disorders and treatments
2021 - Oxford University Press | Brain
Dmitry Golovanov, David Gerada, Giacomo Sala, Michele Degano, Andrew Trentin, Peter H. Connor, Zeyuan Xu, Antonino La Rocca, Alessandro Galassini, Luca Tarisciotti, Carol Eastwick, S. Pickering, Patrick Wheeler, John Clare, Mykhaylo Filipenko, Chris Gerada,
This article describes the underpinning research, development, construction, and testing of a 4-MW multithree phase generator designed for a hybrid-electric aircraft propulsion system demonstrator. The aim of the work is to demonstrate gravimetric power densities around 20 kW/kg, as required for multi-MW aircraft propulsion systems. The key design choices, development procedures, and tradeoffs, together with the experimental testing of this electrical machine connected to an active rectifier, are ...
Tópico(s): Magnetic Bearings and Levitation Dynamics
2021 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Transportation Electrification
Andrew Trentin, Giacomo Sala, Luca Tarisciotti, Alessandro Galassini, Michele Degano, Peter H. Connor, Dmitry Golovanov, David Gerada, Zeyuan Xu, Antonino La Rocca, Carol Eastwick, S. Pickering, Patrick Wheeler, John Clare, Chris Gerada,
In this article, we describe the research and development of a 3 kV active rectifier for a 4 MW aerospace generator drive system demonstrator. The converter is fed by a multiphase high-speed/high-frequency permanent magnet generator. The main aim of the work is to demonstrate for the first time the feasibility of an MW-class generator system meeting future hybrid-electric propulsion requirements. A concept with multiple and isolated three-phase systems feeding different power buses is proposed to ...
Tópico(s): Advanced Battery Technologies Research
2020 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Industrial Electronics
Puvan Arumugam, Zeyuan Xu, Antonino La Rocca, Gaurang Vakil, Matthew Dickinson, Emmanuel Amankwah, Tahar Hamiti, Serhiy Bozhko, Chris Gerada, S. Pickering,
This paper proposes a novel solid rotor topology for an interior permanent magnet (IPM) machine, adopted in this case for an aircraft starter-generator design. The key challenge in the design is to satisfy two operating conditions that are a high torque at start and a high speed at cruise. Conventional IPM topologies that are highly capable of extended field weakening are found to be limited at high speed due to structural constraints associated with the rotor material. To adopt the IPM concept for ...
Tópico(s): Wireless Power Transfer Systems
2016 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Transportation Electrification
Loris Neri, Giusto Viglino, Giancarlo Marinangeli, Anna Rachele Rocca, Alessandro Laudon, Antonino Ragusa, Gianfranca Cabiddu,
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2017 - Springer Science+Business Media | Journal of Nephrology
Massimo Miscusi, Vincenzo Petrozza, Filippo Maria Polli, Stefano Forcato, Carlo Della Rocca, Antonino Raco,
We report the case of a 72-year-old man who underwent surgery for a mobile spondylolisthesis L4-L5. Six months later, magnetic resonance imaging revealed an extradural cyst of the ligamentum flavum at L5-S1, which was then removed. Histological examination revealed a ganglion cyst of the ligamentum flavum. Cyst formation could be explained primarily according to the natural history of chronic degenerative disease of spine elements. Nevertheless, we could also consider the cyst formation as demonstrative ...
Tópico(s): Cervical and Thoracic Myelopathy
2012 - Elsevier BV | Neurologia i Neurochirurgia Polska
Yuzheng Chen, Tao Yang, Muhammad Raza Khowja, Antonino La Rocca, Usman Nasir, Shajjad Chowdhury, D. R. Evans, Dafydd Kember, Thomas Klonowski, Yohan Arnaud, Lucie Apostin, Thierry Liger, Gregory Cossart, Gaurang Vakil, Chris Gerada, Serhiy Bozhko, Sebastien Detry, Christophe Diette, Patrick Wheeler,
This article shares with the aerospace community a case study of turboprop mild hybridization using a recently developed integrated drive system in the University of Nottingham, U.K., within the ACHIEVE project under EU H2020 CleanSky 2 program (project No. 737814). The developed drive system enables the green taxiing of a turboprop aircraft while on the ground with its engine OFF and as an electrical generator when the turboprop is in the air. The entire system is designed to be able to integrate ...
Tópico(s): Silicon Carbide Semiconductor Technologies
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Transportation Electrification
L. Rubino, Jan Piotr Oles, Antonino La Rocca,
Tópico(s): Vehicle emissions and performance
2017 - | SAE technical papers on CD-ROM/SAE technical paper series
Francesco Greco, Antonino Inferrera, Roberto La Rocca, Michele Navarra, Marco Casciaro, Gaetano Grosso, Sebastiano Gangemi, Vincenzo Ficarra, Vincenzo Mirone,
Context Benign prostate hyperplasia (BPH) is one of the most common urologic diseases. However, the molecular and cellular mechanisms involving the stromal and epithelial components of the prostate that lead to BPH remain unclear. Objective To review and evaluate the evidence implicating microRNAs (miRNAs) in the pathogenesis of BPH. Evidence acquisition A systematic search of the PubMed and Embase databases was performed using the terms "benign prostate hypertrophy and miRNA" or ("benign prostate hypertrophy ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2018 - Elsevier BV | European Urology Focus
Giuseppe Palma, Teresa Pasqua, Giovannino Silvestri, Carmine Rocca, Paola Gualtieri, Antônio Barbieri, Anna De Bartolo, Antonino De Lorenzo, Tommaso Angelone, Ennio Avolio, Gerardo Botti,
Expansion of the novel human respiratory coronavirus (SARS-CoV-2) is a global public health emer-gency concern. There is no known successful treatment as of this time and there is a need for medical options to mitigate this current epidemic. SARS-CoV-2 uses the angiotensin-converting enzyme 2 (ACE2) receptor and is primarily trophic for the lower and upper respiratory tract. A number of current studies on COVID-19 demonstrates the substantial increase in pro-inflammatory factors in the lungs during ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Frontiers Media | Frontiers in Immunology
Ermanno Eleuteri, Francesca Magno, Isabella Gnemmi, Marco Carbone, Marilena Colombo, Giampiero La Rocca, Rita Anzalone, Francesco Tarro Genta, Giovanni Zummo, Antonino Di Stefano, Pantaleo Giannuzzi,
In this review, we present recent insights on chronic heart failure (CHF) and the potential role of tumor necrosis factor (TNF)-alpha, interleukins, myeloperoxidase (MPO), and nitrosative stress in the progression of this disease process. Reactive oxygen species (ROS) are produced as a consequence of aerobic metabolism. Under physiologic conditions, their unfavourable effect in causing oxidative damage is counteracted by antioxidants. An imbalance in favour of oxidants leads to oxidative stress, and ...
Tópico(s): Cardiac Fibrosis and Remodeling
2009 - Frontiers in Bioscience | Frontiers in bioscience
Syed Shahjahan Ahmad, Liya Tom, Antonino La Rocca, Salvatore La Rocca, Gaurang Vakil, Chris Gerada, Maamar Benarous,
Safety and reliability of electrical actuators are essential for success of all electric and more electric aircrafts (MEA). Torque limiters improve the reliability of electromechanical actuators (EMA) by restricting the amount of force experienced by the actuator drive train components. If transmitted torque in the shaft exceeds a limit, it gives way in a controlled manner. This protects the actuator from potential failure and jamming. In this paper, different types of existing torque limiters are ...
Tópico(s): Machine Fault Diagnosis Techniques
2022 - Multidisciplinary Digital Publishing Institute | Energies
Giuseppe Fanetti, Daniela Alterio, Giulia Marvaso, Sara Gandini, Damaris Patricia Rojas, Carlo Gobitti, Emilio Minatel, Alberto Revelant, Angela Caroli, Claudia Francia, Ombretta Alessandro, Matteo Pepa, Simone Giovanni Gugliandolo, Anna Starzyńska, Jerry Polesel, Emanuela Vaccher, Maria Cossu Rocca, Marta Tagliabue, Mohssen Ansarin, Valentina Lupato, Vittorio Giacomarra, Antonino De Paoli, Roberto Orecchia, Giovanni Franchin, Barbara Alicja Jereczek‐Fossa,
Abstract Aim To evaluate the role of baseline neutrophil‐to‐lymphocyte ratio (NLR) as prognostic marker in squamous cell carcinoma of the oropharynx (OPC) treated with definitive chemoradiotherapy (CRT) in the era of HPV status. Patients and methods A retrospective analysis of 125 patients (pts) affected with locally advanced OPC was performed. Inclusion criteria were age >18 years, stage III or IV (TNM 7th ed.) and definitive CRT. Haematological marker for their independent role as prognostic biomarkers ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2020 - Wiley | Oral Diseases
Oriana Motta, Antonino Rocca, Valentina Siracusa, Domenico Acierno,
Abstract In this paper we carried out the crosslinking of the tetraglycidyl-4,4′- diaminodiphenyl methane epoxy resin by using a reactive poly(arylene ether sulphone) as curing agent. Differential scanning calorimetry was used to derive the kinetic parameters of the reactions involved in the cure process and to evaluate the extent of the reaction as a function of time by measuring the total (ΔH r ) and the residual heat(ΔH resid ) of the resin at different curing times. A comparatively slower reaction ...
Tópico(s): Fiber-reinforced polymer composites
1999 - De Gruyter | Journal of Polymer Engineering
Nicola Di Daniele, Luigi Petramala, Laura Di Renzo, Francesca Sarlo, Domenico G. Della Rocca, Mariagiovanna Rizzo, Valentina Fondacaro, L Iacopino, Carl J. Pepine, Antonino De Lorenzo,
Metabolic syndrome (MS) is a cluster of metabolic alteration associated with a higher risk of cardiovascular disease and overall mortality than the single alterations alone. The Italian Mediterranean Diet (IMD) can exert a positive effect on cardiovascular risk and related morbidity and mortality. The aim was to evaluate the benefits of dietary intervention based on a typical IMD on body composition, cardiometabolic changes and reduction in cardiovascular disease in patients with MS. Eighty White ...
Tópico(s): Diet, Metabolism, and Disease
2012 - Springer Science+Business Media | Acta Diabetologica
Luca di Marzo, Carlo Della Rocca, Giulia d’Amati, Piero Gallo, Vincenzo Sciacca, Andrea Mingoli, Antonino Cavallaro,
A case of cystic adventitial degeneration (CAD) of the popliteal artery is presented. Histologically the cyst appeared localised in the adventitia, outside the elastic lamina. A lectin-histochemical study evaluated the following peroxidase conjugated lectins: Peanut agglutinin, Concanavalin A, Ulex Europaeus (UEA I) and Wheat Germ Agglutinin. The lack of UEA I reactivity excluded an arterial origin of the cyst. Moreover, the lectin binding pattern of CAD appeared to be similar to the reactivity pattern ...
Tópico(s): Blood properties and coagulation
1994 - Elsevier BV | European Journal of Vascular Surgery
Alessandro Rossi, Mario Amore, Silvana Galderisi, Paola Rocca, Alessandro Bertolino, Eugenio Aguglia, Giovanni Amodeo, Antonello Bellomo, Paola Bucci, Antonino Buzzanca, Bernardo Carpiniello, Anna Comparelli, Liliana Dell’Osso, Massimo Di Giannantonio, Marina Mancini, Carlo Marchesi, Palmiero Monteleone, Cristiana Montemagni, Lucio Oldani, Rita Roncone, Alberto Siracusano, Paolo Stratta, Elena Tenconi, Annarita Vignapiano, Antonio Vita, Patrizia Zeppegno, Mario Maj,
Self-reported 'personal recovery' and clinical recovery in schizophrenia (SRPR and CR, respectively) reflect different perspectives in schizophrenia outcome, not necessarily concordant with each other and usually representing the consumer's or the therapist's point of view. By means of a cluster analysis on SRPR-related variables, we identified three clusters. The first and third cluster included subjects with the best and the poorest clinical outcome respectively. The second cluster was characterized ...
Tópico(s): Mental Health Treatment and Access
2017 - Elsevier BV | Schizophrenia Research
Viviana Moschese, Simona Graziani, Maria Antonietta Avanzini, Rita Carsetti, Massimo Marconi, Marianna La Rocca, L Chini, Claudio Pignata, Annarosa Soresina, Rita Consolini, Grazia Bossi, Antonino Trizzino, Silvana Martino, Fabio Cardinale, Patrizia Bertolini, Gian Luigi Marseglia, Marco Zecca, Silvia Di Cesare, Isabella Quinti, Roberto Rondelli, Maria Cristina Pietrogrande, Paolo Rossi, Alessandro Plebani,
Transient hypogammaglobulinemia of infancy (THI) is a heterogeneous disorder characterized by reduced serum IgG levels in early infancy. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children with an initial diagnosis of THI in correlation to natural outcome, ...
Tópico(s): Blood disorders and treatments
2008 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Antonino Parisi, Luciano Curcio, Vincenzo La Rocca, Salvatore Stivala, Alfonso Carmelo Cino, Alessandro Busacca, Giovanni Cipriani, D. La Cascia, V. Di Dio, Rosario Miceli, G. Ricco Galluzzo,
Starting from the results regarding a nonvacuum technique to fabricate CIGS thin films for solar cells by means of single-step electrodeposition, we focus on the methodological problems of modeling at cell structure and photovoltaic module levels. As a matter of fact, electrodeposition is known as a practical alternative to costly vacuum-based technologies for semiconductor processing in the photovoltaic device sector, but it can lead to quite different structural and electrical properties. For ...
Tópico(s): Silicon and Solar Cell Technologies
2013 - Hindawi Publishing Corporation | International Journal of Photoenergy
Dario Pitocco, Francesco Zaccardi, Pierpaolo Tarzia, Maria Milo, G. Scavone, Paola Rizzo, Francesca Pagliaccia, Roberto Nerla, Antonino Di Franco, Andrea Manto, Bianca Rocca, G. A. Lanza, Filippo Crea, Giovanni Ghirlanda,
Several studies have investigated the effects of metformin treatment in patients with type 1 diabetes mellitus (T1DM). No study has hitherto examined its effects on endothelial function in these patients. In this study we sought to evaluate the effect of metformin on endothelial function in type 1 diabetic patients.Forty-two uncomplicated T1DM patients were randomized in a placebo-controlled, double-blind, 6-month trial to treatment with either metformin or placebo. Glycometabolic and clinical parameters ...
Tópico(s): Diabetes Management and Research
2012 - Wiley | Diabetes Obesity and Metabolism
Antonino Parisi, Riccardo Pernice, Vincenzo La Rocca, Luciano Curcio, Salvatore Stivala, Alfonso Carmelo Cino, Giovanni Cipriani, V. Di Dio, G. Ricco Galluzzo, Rosario Miceli, Alessandro Busacca,
We demonstrate an innovative CIGS-based solar cells model with a graded doping concentration absorber profile, capable of achieving high efficiency values. In detail, we start with an in-depth discussion concerning the parametrical study of conventional CIGS solar cells structures. We have used the wxAMPS software in order to numerically simulate cell electrical behaviour. By means of simulations, we have studied the variation of relevant physical and chemical parameters—characteristic of such devices— ...
Tópico(s): Semiconductor materials and interfaces
2015 - Hindawi Publishing Corporation | International Journal of Photoenergy
Daniela Buonvicino, Giuseppe Ranieri, Daniele Guasti, Alessandra Pistolesi, Antonino Iurato La Rocca, Elena Rapizzi, Alberto Chiarugi,
Derangement of axonal mitochondrial bioenergetics occurs during progressive multiple sclerosis (PMS). However, whether this is a delayed epiphenomenon or an early causative event of disease progression waits to be understood. Answering this question might further our knowledge of mechanisms underlying neurobiology of PMS and related therapy.MOG35-55-immunized NOD and PLP139-151-immunized SJL female mice were adopted as models of progressive or relapsing-remitting experimental autoimmune encephalomyelitis ( ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2023 - Elsevier BV | Neurobiology of Disease
Gaetano Gallo, Arcangelo Picciariello, Gian Luca Di Tanna, G. A. Santoro, Roberto Perinotti, Domenico Aiello, Andrea Avanzolini, Francesco Balestra, Francesco Bianco, Gian Andrea Binda, Gabriele Bislenghi, Andrea Bondurri, Salvatore Bracchitta, Alberto Buonanno, Filippo Caminati, Valerio Celentano, Claudio Coco, F. Colombo, Paola De Nardi, Francesca Di Candido, Salomone Di Saverio, Francesco Ferrara, Cristina Folliero, Iacopo Giani, Maria Carmela Giuffrida, Aldo Infantino, Marco La Torre, Giorgio Lisi, Gaetano Luglio, Anna Maffioli, Stefano Mancini, Michele Manigrasso, Fabio Marino, Jacopo Martellucci, Giovanni Milito, Marco Milone, Simone Orlandi, Massimo Ottonello, Francesco Pata, Gianluca Pellino, Roberto Perinotti, Beatrice Pessia, Arcangelo Picciariello, Aldo Rocca, Lucia Romano, G. A. Santoro, Alberto Serventi, Giuseppe Sica, Rocco Spagnuolo, Antonino Spinelli, A. Testa, Mario Trompetto, Roberta Tutino, Antonella Veglia, G Zaffaroni, Ugo Grossi,
Coronavirus disease 2019 (COVID-19) is revolutionizing healthcare delivery. The aim of the study was to reach consensus among experts on the possible applications of telemedicine in colorectal surgery. A group of 48 clinical practice recommendations (CPRs) was developed by a clinical guidance group based on coalescence of evidence and expert opinion. The Telemedicine in Colorectal Surgery Italian Working Group included 54 colorectal surgeons affiliated to the Italian Society of Colo-Rectal Surgery ( ...
Tópico(s): Social Media in Health Education
2021 - Springer Science+Business Media | Updates in Surgery
Giampiero La Rocca, Rita Anzalone, Simona Corrao, Francesca Magno, Tiziana Loria, Melania Lo Iacono, Antonino Di Stefano, Pantaleo Giannuzzi, L Marasà, Francesco Cappello, Giovanni Zummo, Felicia Farina,
Tópico(s): Organ and Tissue Transplantation Research
2008 - Springer Science+Business Media | Histochemistry and Cell Biology