Antonio Vitale, Valeria Caggiano, Antonio Bimonte, Federico Caroni, Gian Marco Tosi, Alessandra Fabbiani, Alessandra Renieri, Monica Bocchia, Bruno Frediani, Claudia Fabiani, Luca Cantarini,
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is a recently described pathological entity. It is an acquired monogenic autoinflammatory disease caused by somatic mutations of the UBA1 gene in blood cells precursors; the gene encodes one of the two E1 enzyme isoforms that initiates ubiquitylation in cell's cytoplasm. VEXAS syndrome leads to systemic inflammation, with all organs and tissues potentially involved. The clinical picture may be extremely heterogenous, mimicking ...
Tópico(s): Vascular Anomalies and Treatments
2023 - Springer Science+Business Media | Internal and Emergency Medicine
Joaquim A. O. Barros, Beatriz Sanz, Marcílio M. A. Filho, Fábio P. Figueiredo, Petr Kabele, Rena C. Yu, Günther Meschke, J. Planas, Vítor M. C. F. Cunha, Antonio Caggiano, Nilüfer Özyurt, A. Ventura Gouveia, Ab van den Bos, Elisa Poveda, Erez Gal, J Červenka, Gerrit E. Neu, Pierre Rossi, Daniel Dias‐da‐Costa, Károly Péter Juhász, David Ángel Cendón Franco, Gonzalo Ruiz, Tiago Valente,
Abstract This article describes the second blind simulation competition (BSC) organized by the fib WG 2.4.1, which aims to assess the predictive performance of models based on the finite element method (FEM) for the analysis and design of fiber reinforced concrete (FRC) structures. Slabs supported on columns or piles have becoming competitive applications for FRC due to the technical and economic benefits may be obtained by combining properly the fiber reinforcement mechanisms to those provided by ...
Tópico(s): Structural Load-Bearing Analysis
2023 - Wiley | Structural Concrete
Mona Nazari Sam, António Caggiano, Liliya Dubyey, Jean‐Luc Dauvergne, Eddie Koenders,
This paper reports a comprehensive experimental investigation of cement pastes enhanced with Microencapsulated Phase Change Materials (MPCM) for Thermal Energy Storage (TES) purposes. The experimental plan considers three water-to-binder ratios and three MPCM volume fractions, for a total of nine different MPCM paste mixtures. The water-to-binder ratios of the pastes are 0.33, 0.40 and 0.45, which were mixed with a commercial MPCM, namely Nextek 37D® having a melting/solidification temperature of ...
Tópico(s): Solar Energy Systems and Technologies
2022 - Elsevier BV | Construction and Building Materials
Hernán Xargay, Marianela Ripani, Paula Folino, Nicolás Núñez, António Caggiano,
In this work, the Acoustic Emissions (AEs), detected in real-scale Reinforced Concrete (RC) beams which have been tested under four-point bending, are investigated and correlated with their structural responses and damage evolutions. Two different reinforcing bar arrangements, with or without shear stirrups, were designed in order to obtain bending or shear failure modes, respectively. Moreover, some of the beams were casted with the addition of steel fibers in the concrete mixture. A loading procedure ...
Tópico(s): Ultrasonics and Acoustic Wave Propagation
2020 - Elsevier BV | Construction and Building Materials
Mona Nazari Sam, António Caggiano, Christoph Mankel, Eddie Koenders,
Thermal-Energy Storage (TES) properties of organic phase change materials have been experimentally investigated and reported in this paper. Three paraffin-based Phase Change Materials (PCMs) and one bio-based PCM are considered with melting temperatures of 24 °C, 25 °C and 26 °C. Sensible heat storage capacities, melting characteristics and latent heat enthalpies of the studied PCMs are investigated through Differential Scanning Calorimetry (DSC) measurements. Two alternative methods, namely the classical ...
Tópico(s): Solar Thermal and Photovoltaic Systems
2020 - Multidisciplinary Digital Publishing Institute | Materials
Joaquim A. O. Barros, Beatriz Sanz, Petr Kabele, Rena C. Yu, Günther Meschke, J. Planas, Vítor M. C. F. Cunha, Antonio Caggiano, Nilüfer Özyurt, A. Ventura Gouveia, Ab van den Bos, Elisa Poveda, Erez Gal, J Červenka, Gerrit E. Neu, Pierre Rossi, Daniel Dias‐da‐Costa, Károly Péter Juhász, David Ángel Cendón Franco, Gonzalo Ruiz, Tiago Valente,
Abstract Experimental research has shown the extraordinary potential of the addition of short fibers to cement‐based materials by improving significantly the behavior of concrete structures for serviceability and ultimate limit states. Software based on the finite element method has been used for the simulation of the material nonlinear behavior of fiber‐reinforced concrete (FRC) structures. The applicability of the existing approaches has often been assessed by simulating experimental tests with ...
Tópico(s): Structural Load-Bearing Analysis
2020 - Wiley | Structural Concrete
Sha Yang, Fadi Aldakheel, António Caggiano, Peter Wriggers, Eddie Koenders,
Improving the durability and sustainability of concrete structures has been driving the enormous number of research papers on self-healing mechanisms that have been published in the past decades. The vast developments of computer science significantly contributed to this and enhanced the various possibilities numerical simulations can offer to predict the entire service life, with emphasis on crack development and cementitious self-healing. The aim of this paper is to review the currently available ...
Tópico(s): Innovations in Concrete and Construction Materials
2020 - Multidisciplinary Digital Publishing Institute | Materials
Vı́ctor D. Fachinotti, Facundo Bre, Christoph Mankel, Eddie Koenders, António Caggiano,
This work proposes a numerical procedure to simulate and optimize the thermal response of a multilayered wallboard system for building envelopes, where each layer can be possibly made of Phase Change Materials (PCM)-based composites to take advantage of their Thermal-Energy Storage (TES) capacity. The simulation step consists in solving the transient heat conduction equation across the whole wallboard using the enthalpy-based finite element method. The weather is described in detail by the Typical ...
Tópico(s): Adsorption and Cooling Systems
2020 - Multidisciplinary Digital Publishing Institute | Materials
Stefan Harenberg, Matthias Pahn, Viktória Malárics‐Pfaff, Frank Dehn, António Caggiano, Diego Said Schicchi, Sha Yang, Eddie Koenders,
Abstract This paper provides experimental results on investigations for the validation of photogrammetric strain measurements of ultra‐high‐performance concrete (UHPC)‐prisms subjected to static and cyclic bending‐tensile stress. For this purpose, 4 static and 5 cyclic test series were performed. Damage progresses during loading are monitored by means of a digital image correlation (DIC) system and a clip gauge. The control of the DIC by trigger lists and the measurement noise as a function of the ...
Tópico(s): Structural Behavior of Reinforced Concrete
2019 - Wiley | Structural Concrete
Christoph Mankel, António Caggiano, Eddie Koenders,
This paper reports the results of an experimental program on sustainable cementitious composites made with Recycled Brick Aggregates (RBAs) employed as carriers for Phase-Change Materials (PCMs). The PCM-RBAs were produced by following an advanced incorporation and immobilization technique, developed and patented at the Institut für Werkstoffe im Bauwesen – TU Darmstadt. Spherical mortar samples made of plain cement paste plus porous RBAs, filled with liquid paraffinic wax, were used for monitoring ...
Tópico(s): Innovations in Concrete and Construction Materials
2019 - Elsevier BV | Energy and Buildings
Hernán Xargay, Paula Folino, Nicolás Núñez, Martín Gómez, António Caggiano, Enzo Martinelli,
This paper investigates the effect of high temperature on two different Self-Compacting (SC) cementitious composites. SC-High Strength (SCHSC) and Fiber-Reinforced Concrete (SCHSFRC) samples were tested in three-point bending after having been exposed to high temperature at 300 and 600 °C. Besides the conventional force-displacement response, Acoustic Emission (AE) activity was monitored during the bending tests with the aim to investigate the possible correlation between the fracture behavior, the rate ...
Tópico(s): Concrete Properties and Behavior
2018 - Elsevier BV | Construction and Building Materials
António Caggiano, Diego Said Schicchi, Christoph Mankel, Neven Ukrainczyk, Eddie Koenders,
This paper proposes a mesoscale approach for simulating moisture transport by capillary action in partly-saturated porous cementitious composites. The modeling approach explicitly accounts for moisture transport through a mesostructure composed of coarse aggregates, surrounding cementitious mortar and interfaces. These latter, namely interface transition zones (ITZs), allow to describe the interaction between aggregates and mortar, and may cause an alternative path for the internal moisture movements. ...
Tópico(s): Geotechnical Engineering and Underground Structures
2018 - Elsevier BV | Computers & Structures
António Caggiano, Christoph Mankel, Eddie Koenders,
Accumulating solar and/or environmental heat in walls of apartment buildings or houses is a way to level-out daily temperature differences and significantly cut back on energy demands. A possible way to achieve this goal is by developing advanced composites that consist of porous cementitious materials with embedded phase change materials (PCMs) that have the potential to accumulate or liberate heat energy during a chemical phase change from liquid to solid, or vice versa. This paper aims to report ...
Tópico(s): Solar Thermal and Photovoltaic Systems
2018 - Multidisciplinary Digital Publishing Institute | Buildings
António Caggiano, Enzo Martinelli, Diego Said Schicchi, Guillermo Etse,
This paper proposes a model aimed at simulating the strain-rate effect in Fiber Reinforced Polymer (FRP) strips glued to concrete. More specifically, the loading rate-dependent bond mechanisms are evaluated by extending a classical overstress viscoplastic approach, available in the literature, generally referred to as Duvaut-Lions' approach. The model is formulated within the general theoretical framework of fracture mechanics under the assumption that debonding occurs as a pure mode II cracking ...
Tópico(s): Innovative concrete reinforcement materials
2018 - Elsevier BV | Composites Part B Engineering
Christoph Mankel, António Caggiano, Neven Ukrainczyk, Eddie Koenders,
This work reports a detailed experimental study that is aimed at investigating the Thermal Energy Storage (TES) performance of cementitious systems containing Microencapsulated Phase Change Materials (MPCMs). New spherical-shaped test specimens for TES measurements were produced following an innovative casting technique, developed at the Institut für Werkstoffe im Bauwesen – TU Darmstadt. Three water-to-cement ratios and three MPCMs volume fractions, leading to a total of nine different mixtures, were ...
Tópico(s): Polymer composites and self-healing
2018 - Elsevier BV | Construction and Building Materials
Matías Fernando Benedetto, António Caggiano, Guillermo Etse,
A novel procedure for analyzing fracture processes in quasi-brittle materials and consisting in combining the discrete crack approach by means of interface elements with the Virtual Element Method is proposed and developed in this work. In particular, the proposed procedure is used in the simulation of non-linear mechanical response and cracking of cement-based composites at the mesoscopic level of observation. Thereby three components are recognized: mortar, coarse aggregates and mortar–aggregate ...
Tópico(s): Composite Material Mechanics
2018 - Elsevier BV | Computer Methods in Applied Mechanics and Engineering
Joaquim A. O. Barros, Cristina Frazão, António Caggiano, Paula Folino, Enzo Martinelli, Hernán Xargay, Zia Zamanzadeh, L. Lourenço,
Pneumatic tyres are nowadays among the most widespread industrial products and, hence, handling tyres that have reached their end-of-life is indeed a critical issue. This Chapter provides readers with the key facts about tyre production and consumption. Particularly, it describes the raw materials which they are made from, and summarises the main classifications currently accepted worldwide. The typical product life-cycle is shortly outlined before analysing the possibility of recycling waste tyres ...
Tópico(s): Structural Behavior of Reinforced Concrete
2017 - Springer International Publishing | Research for development
António Caggiano, Paula Folino, Carmine Lima, Enzo Martinelli, Marco Pepe,
This paper summarizes the results of an experimental research on "sustainable" cementitious composites internally reinforced with industrial and recycled steel fibers, the latter being recovered from waste tires and employed in substitution and/or addition of the industrial steel ones. Specifically, six concrete mixtures including different amount of industrial/recycled steel fibers were produced and tested both in compression and bending. The obtained results confirm the promising prospects already ...
Tópico(s): Structural Behavior of Reinforced Concrete
2017 - Elsevier BV | Construction and Building Materials
António Caggiano, Guillermo Etse, Liberato Ferrara, Visar Krelani,
A damage-plasticity constitutive theory for zero-thickness interfaces is presented aimed at predicting time-dependent self-healing phenomena in concrete. The material model is based on fracture-energy concepts and accounts for the time evolution of concrete porosity induced by the self-healing mechanism. The accuracy and soundness of the proposed interface model are demonstrated through comparative analyses of model predictions against experimental results on three point beam tests performed up ...
Tópico(s): Concrete and Cement Materials Research
2017 - Elsevier BV | Computers & Structures
António Caggiano, Diego Said Schicchi, Guillermo Etse, Marianela Ripani,
Tópico(s): Rock Mechanics and Modeling
2017 - Elsevier BV | Engineering Failure Analysis
António Caggiano, Serena Gambarelli, Enzo Martinelli, Nicola Nisticò, Marco Pepe,
This paper presents and discusses the results of experimental tests performed on concrete specimens internally reinforced with polypropylene and steel fibers. Specifically, samples of five mixtures (plus a reference plain concrete), characterized by the same total volume of fibers, but different fractions of polypropylene and steel fibers, were tested under compression and in bending. This study was aimed to clarify the influence of different combinations of these fibers on the resulting fracture ...
Tópico(s): Concrete and Cement Materials Research
2016 - Elsevier BV | Construction and Building Materials
Enzo Martinelli, António Caggiano, Hernán Xargay,
This paper investigates the mechanical behaviour of FRC made with both Industrial and Recycled Steel Fibres recovered from waste tyres. Specimens of various mixtures, characterised by the same volume fraction of fibres, but different proportions of industrial and recycled reinforcement were tested both in compression and bending. The results highlighted a fairly negligible influence of fibres in terms of compressive strength, whereas a significant decay in the post-cracking behaviour was observed ...
Tópico(s): Concrete and Cement Materials Research
2015 - Elsevier BV | Construction and Building Materials
António Caggiano, Hernán Xargay, Paula Folino, Enzo Martinelli,
This work investigates the mechanical behavior of recycled steel fibers recovered from waste tires and, then, suitable to produce eco-friendly fiber-reinforced concrete. Particularly, the results of an experimental investigation aimed at understanding the tensile response of the aforementioned steel fibers and their bond behavior when embedded in cementitious matrices are reported and discussed. Moreover, as a case study, a fracture-based plasticity formulation for simulating the overall pull-out ...
Tópico(s): Structural Behavior of Reinforced Concrete
2015 - Elsevier BV | Cement and Concrete Composites
António Caggiano, Guillermo Etse,
A thermo–mechanical interface model for failure analysis of concrete subjected to high temperature is presented in this work. The model is an extension of a fracture energy-based interface formulation which now includes thermal damage induced by high temperature and/or fire. The coupled thermal–mechanical effect in the interface model is taken into account through the formulation of a temperature dependent maximum strength criterion and fracture energy-based softening or post-cracking rule. In this ...
Tópico(s): Rock Mechanics and Modeling
2015 - Elsevier BV | Computer Methods in Applied Mechanics and Engineering
Enzo Martinelli, António Caggiano,
The mechanical behavior of the adhesive interface between the fiber-reinforced polymer (FRP) strip and the concrete substrate often controls the response of FRP-strengthened reinforced concrete (RC) members. Plenty of studies devoted to understanding the mechanical behavior of FRP strips glued to concrete are currently available in the scientific literature. However, they are mainly focused on the response under monotonic actions, which is certainly relevant in a wide class of practical applications. ...
Tópico(s): Structural Response to Dynamic Loads
2014 - Multidisciplinary Digital Publishing Institute | Polymers

Enzo Martinelli, Eddie Koenders, António Caggiano,
This paper presents a sound theoretical formulation and an effective numerical implementation of a heat-flow and hydration model for concrete hardening. The model is based on the Fourier equation of heat flow with the adiabatic hydration curve employed as a reference for simulating the hydration heat source. The proposed formulations are based on a consistent scheme for the partial differential equation and its boundary and starting conditions. The hydration kinetics is simulated through the Arrhenius ...
Tópico(s): Innovative concrete reinforcement materials
2013 - Elsevier BV | Cement and Concrete Composites
Carmine Lima, António Caggiano, Ciro Faella, Enzo Martinelli, Marco Pepe, Roberto Realfonzo,
Enhancing the environmental sustainability of human activities and industrial processes is a common challenge in various branches of modern research and technology. Being characterised by a huge demand of both energy and raw materials and by a significant contribution to the global emissions of greenhouse gases (GHGs), the construction industry is fully concerned by this challenge. Particularly, since concrete is the most widely used construction material, several solutions are nowadays under investigation ...
Tópico(s): Concrete and Cement Materials Research
2013 - Elsevier BV | Construction and Building Materials
António Caggiano, Enzo Martinelli, Ciro Faella,
Composite materials, such as fiber reinforced polymers (FRP), are more and more common as strengthening solution for existing structures. Adhesion between FRP and the existing substrate generally represents one of the main concerns on the effectiveness of these techniques. The bond behaviour of composite materials on concrete substrates (but also steel, masonry and wooden ones) are generally investigated by means of pull-out tests. The present paper, starting from the most common assumptions of the ...
Tópico(s): Structural Load-Bearing Analysis
2012 - Elsevier BV | International Journal of Solids and Structures
António Caggiano, Enzo Martinelli,
The present paper deals with the bond behaviour of Fibre Reinforced Polymer (FRP) laminates glued to brittle substrates. Based on a similar proposal already available in the scientific literature for discrete-crack analyses on plain concrete, this work formulates a numerical model completely conceived within the general framework of Fracture Mechanics and plasticity-based concepts. This is the key novel aspect of the proposed work, whereas, as a matter of fact, the most common proposals and theoretical ...
Tópico(s): Structural Response to Dynamic Loads
2012 - Elsevier BV | Composite Structures
António Caggiano, Guillermo Etse, Enzo Martinelli,
This paper deals with simulating the mechanical response of fiber-reinforced cementitious composites (FRCCs) by means of a zero-thickness interface model formulated within the framework of discrete-crack approaches. Following a similar model already available in literature for plain concrete, the formulation of the interface element is further developed and extended to capture the key mechanical phenomena controlling the FRCC behavior. An original approach is introduced for reproducing the complex ...
Tópico(s): Numerical methods in engineering
2012 - Elsevier BV | Computers & Structures