Andrew Robson, Raymond Snoddy Media Editor, Helen Buck, Stephen Byers, Helen Daniel, Catherine Riley, DJM, Paul Keller, J. M. Agar, James Moore, Simon Barnes, James Chater, Peter Lansley, Sam Peates, Robert Thicknesse, Paul Hoggart, Geraint Llewelyn, W. G. Leeks, Ronald Faux, Mark Souster, David Rhys Jones, Andrew Norfolk and Lea Paterson, Philip Howard, Ian Cobain, Rev Frank Julian Gelli, Hilary Finch, David Chater, Charles Bremner Foreign Briefing, David Stuart, Alexandra Frean Social Affairs Correspondent, Elizabeth Judge, Roger Maynard, Zoran Kusovac and Our Foreign Staff, Geoff Brown, Jane Mactaggart, Sam Lister, David Sharrock, John Fairweather-Tall, Ben Webster Transport Correspondent, Gary Duncan Economic Agenda, Mark Griffiths, Mary Wilkinson (Editor), Thrasy Petropoulos, Simon Kuper, Jennai Cox Fitness Editor, Dominic Walsh, Valerie Elliott and Anne Spackman, Debra Craine, Shirley English, Norman Harris, Tim Reid, Dan Sabbagh, Oliver Del Mar, Neil Cossons, Chairman, Alan Hamilton, Stephen Farrell, David Seaman, Ian Baird (Exam officer), Michael Tillotson, Anthony G. Phillips, Miranda Ingram, Ralph Dellow, Roland Watson, Ion Markides, David Hands, Chris Johnston, Ron Lewis, Caroline Merrell Banking Correspondent, Angela Jameson, Robert Cooper, Vanora Bennett, Tony Halpin Education Editor, Daniel McGrory, Oliver Kay, Peter Enckelman, Sarah Vine, Michael Theodoulou, Professor John Bynner, Rick Broadbent, Stephen Burgen, Jill Sherman Whitehall Editor, Sam Coates, Mark Henderson Science Correspondent, Antonio Cassano, Richard Wright, John Hopkins Golf Correspondent, Geoffrey Dean, Rob Wright, Neil Harman Tennis Correspondent, Jane Monckton-Smith, Raymond Keene, H. W. R. Wade, Christine Buckley, Matthew Pryor, Tim Bloomfield, Jerzy Dudek, Christine Buckley Industrial Editor, Zoran Kusovac, Derek Forrest, Koder Nahaboo, Nigel Hawkes, Caroline Merrell, Russell Hotten, Cathy Harris, Susan Kelly, Richard Owen, Anthony Browne Environment Editor, Helen Nugent, Christopher Martin-Jenkins Chief Cricket Correspondent, Jerome Pugmire, Martin Woods, Emily Davies, David Hands Rugby Correspondent, Tony Cascarino, Tom Dart, Glen Owen, Alan Lee Racing Journalist of the Year, William Rees-Mogg, John Goodbody, Jonathan Clayton, Philip Webster Political Editor, Heather Robson, Jane Shilling, Brian MacArthur, Tim Hames, Mel Webb, Pennie Stringer, Ashling O'connor, Martin Waller Student Briefing, Glen Owen Education Correspondent, Paul Jones, Walter Gammie, Philip Webster and Jill Sherman, Lea Paterson Economics Editor, Bob Yule, Sylvia Sobernheim, Michael Dynes, David Cotterill, Jack Malvern Arts Reporter, David Sinclair, Stella Rimington, Christopher Irvine, James Jackson, Nigel Hawkes Health Editor, Sarah Butler, Daniel Rosenthal, Benedict Nightingale, Dr Thomas Stuttaford, Stephen Dalton, Alyson Rudd, Paul Connolly, David Powell, Bill Edgar, Brian Clarke Fishing Correspondent, Dave Hammond, Bryan Reuben, Edward Gorman Sailing Correspondent, Kamran Younas, Jeremy Griffin, Gerald Davies Scouting Report, Michael Harman, Charles Wardle (Conservative MP), Mark Wallington,
... Game Features Plus Results and Reports Hairapparent 16. Antonio Cassano It's Blue Murder Being the Boss With ...
2002 - Gale Group | TDA
Lionella Palego, Luciano Biondi, Gino Giannaccini, Nannina Sarno, S. A. Elmi, Antonio Ciapparelli, Giovanni Battista Cassano, Antonio Lucacchini, Claudia Martini, Liliana Dell’Osso,
Steady-state plasma concentrations of clozapine and norclozapine, its major metabolite, as well as their sum and ratio (norclozapine/clozapine), were evaluated in 50 in- and outpatients taking clozapine and naturalistically recruited. Drug plasma concentrations were measured by means of a reversed-phase high-performance liquid chromatography (RPLC) method with an ultraviolet detection. Daily doses (milligrams per kilogram of body weight) of clozapine correlated positively with clozapine plasma parameters, ...
Tópico(s): Tryptophan and brain disorders
2002 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Moris Sangineto, Martina Ciarnelli, Tommaso Cassano, Antonio Radesco, Archana Moola, Vidyasagar Naik Bukke, Antonino Davide Romano, Rosanna Villani, Hina Kanwal, Nazzareno Capitanio, Loren Duda, Carlo Avolio, Gaetano Serviddio,
Microglia activation drives the pro-inflammatory activity in the early stages of Alzheimer's disease (AD). However, the mechanistic basis is elusive, and the hypothesis of targeting microglia to prevent AD onset is little explored. Here, we demonstrated that upon LPS exposure, microglia shift towards an energetic phenotype characterised by high glycolysis and high mitochondrial respiration with dysfunction. Although the activity of electron transport chain (ETC) complexes is boosted by LPS, this is ...
Tópico(s): Immune cells in cancer
2023 - Elsevier BV | Redox Biology
Cristiana Bolchini, Luca Cassano, Antonio Miele, A. Toschi,
The great quest for adopting AI-based computation for safety-/mission-critical applications motivates the interest towards methods for assessing the robustness of the application w.r.t. not only its training/tuning but also errors due to faults, in particular soft errors, affecting the underlying hardware. Two strategies exist: architecture-level fault injection and application-level functional error simulation. We present a framework for the reliability analysis of Convolutional Neural Networks ( ...
Tópico(s): Semiconductor materials and devices
2022 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Computers
Giacomo Tanganelli, Luca Cassano, Antonio Miele, Carlo Vallati,
The pervasiveness and the growing processing capabilities of mobile and embedded computing systems are leading to a shift from the Internet of Things (IoT) paradigm to the Fog computing scenario where the environment is instrumented with high-performance computing in the proximity to cyber–physical systems. The design of such systems requires an accurate planning, on the one hand, to ensure that specific application requirements will be properly met at run-time, and, on the other hand, to minimize ...
Tópico(s): Green IT and Sustainability
2020 - Elsevier BV | Future Generation Computer Systems
Velia Cassano, Antonio Leo, Martina Tallarico, Valentina Nesci, Antonio Cimellaro, Teresa Vanessa Fiorentino, Rita Citraro, Marta Letizia Hribal, Giovambattista De Sarro, Francesco Perticone, Giorgio Sesti, Emilio Russo, Angela Sciacqua,
Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment. Ranolazine, an anti-ischemic drug used in the treatment of angina pectoris, has been shown to possess hypoglycemic properties in pre-clinical and clinical studies. The aim of this study was to evaluate the effects of ranolazine on glucose metabolism and cognitive function in a T2DM model of Wistar rats. Diabetes was induced by a high fat diet (HFD) and streptozotocin (STZ). The control group received a normal caloric diet (NCD) ...
Tópico(s): Adipose Tissue and Metabolism
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Sabrina Rossi, Vincenzo Di Noia, Laura Tonetti, Antonia Strippoli, Michele A. Basso, Giovanni Schinzari, Alessandra Cassano, Antonio Leone, Carlo Barone, Ettore D’Argento,
Aim: To evaluate gefitinib outcomes in EGFR-mutated non-small-cell lung cancer (NSCLC) patients harboring EGFR mutations, according to their sarcopenia status. Patients & methods: We retrospectively evaluated 33 patients with advanced NSCLC and EGFR mutations (exon 19 or 21), dividing them into sarcopenic patients, with low skeletal muscle index ≤39 cm2/m2 for women and ≤55 cm2/m2 for men, and nonsarcopenic patients. Results: Sarcopenia does not affect response to gefitinib treatment in EGFR mutated NSCLC ...
Tópico(s): GDF15 and Related Biomarkers
2018 - Future Medicine | Future Oncology
Fabio Cassano, Antonio Piccinno, Teresa Roselli, Veronica Rossano,
Gamification is one of the most used techniques to improve active participation and engagement in different kinds of contexts. The use of game techniques is effective in pushing subjects to be involved in an activity. Since the early childhood, indeed, the promises of rewards are useful to affect specific behaviors. On the other hands, the learning analytics have been largely implemented in education in order to improve the assessment and the self-assessment of students, above all in e-learning ...
Tópico(s): E-Learning and Knowledge Management
2018 - Springer Nature | Advances in intelligent systems and computing
Ricardo Cardona‐Guarache, Santosh K. Padala, Luis Velazco‐Davila, Anthony Cassano, Antonio Abbate, Kenneth A. Ellenbogen, Jayanthi N. Koneru,
Abstract Autonomic modulation is being increasingly employed as a strategy to treat ventricular arrhythmias refractory to beta‐blockers, antiarrhythmic drugs, and catheter‐based ablation procedures. We report 6 patients with refractory ventricular tachycardia (VT) or ventricular fibrillation (VF) treated with stellate ganglion blockade (SGB) and/or bilateral cardiac sympathetic denervation (CSD). Our case series emphasizes the concept that the cardiac sympathetic nerves are important targets in the ...
Tópico(s): Pain Management and Treatment
2017 - Wiley | Journal of Cardiovascular Electrophysiology
Tommaso Cassano, Antonio Lopalco, Modesto de Candia, Valentino Laquintana, Angela Lopedota, Annalisa Cutrignelli, Mara Perrone, Rosa Maria Iacobazzi, Gaurav Bedse, Massimo Franco, Nunzio Denora, Cosimo Altomare,
The neurotransmitter dopamine (DA) was covalently linked to oxazepam (OXA), a well-known positive allosteric modulator of γ-aminobutyric acid type-A (GABAA) receptor, through a carbamate linkage (4) or a succinic spacer (6). These conjugates were synthesized with the aim of improving the delivery of DA into the brain and enhancing GABAergic transmission, which may be useful for the long-term treatment of Parkinson disease (PD). Structure-based permeability properties, in vitro stability, and blood-brain ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2017 - American Chemical Society | Molecular Pharmaceutics
Laura Giusti, Valentina Mantua, Ylenia Da Valle, Federica Ciregia, Tiziana Ventroni, G. Orsolini, Elena Donadio, Gino Giannaccini, Mauro Mauri, Giovanni Battista Cassano, Antonio Lucacchini,
Data on neurobiological mechanisms underlying mood disorders are elusive; the aetiology of such states is multifactorial, including genetic predisposition and environmental factors. Diagnosis is currently being made only on an interview-based methodology. Biological markers, which could improve the current classification, and in perspective, stratify patients on a biological basis into more homogeneous clinically distinct subgroups, are highly needed. We describe here a comparative proteomic analysis ...
Tópico(s): Schizophrenia research and treatment
2014 - Royal Society of Chemistry | Molecular BioSystems
Pierina Ielpo, Daniela Cassano, Antonio López, Giuseppe Pappagallo, Vito Felice Uricchio, Pasquale Abbruzzese De Napoli,
Ground waters are an important resource of water supply for human health and activities. Groundwater uses and applications are often related to its composition, which is increasingly influenced by human activities.In fact the water quality of groundwater is affected by many factors including precipitation, surface runoff, groundwater flow, and the characteristics of the catchment area. During the years 2004-2007 the Agricultural and Food Authority of Apulia Region has implemented the project "Expansion ...
Tópico(s): Water Quality Monitoring and Analysis
2012 - BioMed Central | Chemistry Central Journal
Nicoletta Cassano, Antonio Puglisi Guerra, Giovanna Malara, Francesco Loconsole, A. Galluccio, M Pezza, Gino Antonio Vena,
Infliximab is an anti-tumour necrosis factor-alpha chimeric monoclonal antibody which is highly effective in psoriasis, as well as in other indications. In clinical practice, some patients may require dose escalation to overcome a reduction of the extent and/or duration of response during regular maintenance treatment, possibly due to the loss of stable serum concentrations of the drug. Common strategies of dose escalation are the increase of dose per infusion and the decrease of interval between ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2007 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Nicola Quaranta, Michele Cassano, Antonio Quaranta,
Report the clinical presentation and outcome of the cases of 13 patients with facial paralysis and acquired middle ear and mastoid cholesteatoma.Patients with acquired cholesteatoma of the middle ear presenting with facial paralysis.Surgical treatment of the cholesteatoma and decompression of the facial nerve.The type and the timing of surgery, the intraoperative findings, and the postoperative facial nerve results were analyzed and related to the preoperative facial nerve function.All patients ...
Tópico(s): Ear and Head Tumors
2007 - Lippincott Williams & Wilkins | Otology & Neurotology
Beatrice Chelli, Stefano Pini, Marianna Abelli, Alessandra Cardini, Lisa Lari, Matteo Muti, Camilla Gesi, Giovanni Battista Cassano, Antonio Lucacchini, Claudia Martini,
Recent studies indicate that Adult Separation Anxiety Disorder (ASAD) may represent a discrete diagnostic entity worthy of attention. Adults with separation anxiety report extreme anxiety and fear about separations from major attachment figures (partner, children or parents). These symptoms affect individual's behavior, lead to severe impairment in social relationships and are not better accounted for by the presence of agoraphobia. In a previous study we found platelet expression reduction of the ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2007 - Elsevier BV | European Neuropsychopharmacology
Andrea Sardella, Giovanni Lodi, Federica Demarosi, Cristina Bez, Susanna Cassano, Antonio Carrassi,
Objective: The aim of this investigation was to evaluate the spontaneous remission rate of burning mouth syndrome (BMS) in a group of subjects suffering from this syndrome. Subjects and Methods: The medical records of BMS patients attending the Unit of Oral Medicine (1995–2002) were reviewed. The patients with a follow‐up period of at least 18 months were then contacted over phone and interviewed using a structured ad hoc questionnaire to record their current symptoms and data about their treatment ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2006 - Wiley | Oral Diseases
Francesco Carinci, Lazzaro Cassano, Antonio Farina, Stefano Pelucchi, C Calearo, Vincenzo Modugno, Ingrid Nielsen, P. Api, Antonio Luigi Pastore,
A study regarding patients with primary and previously untreated advanced histologically proven squamous cell carcinoma of the head and neck was performed to compare two treatment modalities: neck dissection followed by chemoradiotherapy (Group I) versus chemoradiotherapy alone (Group II). Fifty-four patients were randomly chosen to receive Group I or II treatment. Our results demonstrate that Group I treatment has a higher and statistically significant disease-specific survival rate. We suggest that ...
Tópico(s): Tumors and Oncological Cases
2001 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery
Donatella Marazziti, Laura Betti, Gino Giannaccini, Alessandra Rossi, I. Másala, Stefano Baroni, Giovanni Battista Cassano, Antonio Lucacchini,
Tópico(s): Memory and Neural Mechanisms
2001 - Springer Science+Business Media | Neurochemical Research
Roberto Iezzi, Alessandro Posa, Biagio Merlino, Maurizio Pompili, Eleonora Annicchiarico, Elena Rodolfino, Michele A. Basso, Alessandra Cassano, Antonio Gasbarrini, Riccardo Manfredi,
We aimed to analyze transradial access (TRA) learning curve on patients undergoing hepatic chemoembolization, investigating the relationship between procedural volumes and various benchmarks of procedural success.We enrolled 60 consecutive patients who received two unilobar hepatic chemoembolizations within a 4-week interval performed by a single interventional radiologist, highly-trained in conventional transfemoral access (TFA) procedures, but without any previous practical experience in TRA procedures ...
Tópico(s): Ultrasound in Clinical Applications
2019 - | Diagnostic and Interventional Radiology
Barbara Costa, Stefano Pini, Claudia Martini, Marianna Abelli, P Gabelloni, Stefano Landi, Matteo Muti, Camilla Gesi, Lisa Lari, Alessandra Cardini, Silvana Galderisi, Armida Mucci, Antonio Lucacchini, Giovanni Battista Cassano,
... Lisa; Cardini, Alessandra; Galderisi, Silvana; Mucci, Armida; Lucacchini, Antonio; Cassano, Giovanni Battista Author Information
Tópico(s): Intensive Care Unit Cognitive Disorders
2009 - Lippincott Williams & Wilkins | Psychiatric Genetics
Nicola Arpaia, Nicoletta Cassano, Gino Antonio Vena,
... more papers by this authorNICOLETTA CASSANO MD, NICOLETTA CASSANO MD All authors are affiliated with 2nd Unit of Dermatology, MIDIM Department, University of Bari, ItalySearch for more papers by this authorGINO ANTONIO VENA MD, GINO ANTONIO VENA MD All authors ... more papers by this authorNICOLETTA CASSANO MD, NICOLETTA CASSANO MD All authors are affiliated with 2nd Unit of Dermatology, MIDIM Department, University of Bari, ItalySearch for more papers by this authorGINO ANTONIO VENA MD, GINO ANTONIO VENA MD All authors ...
Tópico(s): Cutaneous lymphoproliferative disorders research
2006 - Lippincott Williams & Wilkins | Dermatologic Surgery
Manuele Casale, Andrea Costantino, Lorenzo Sabatino, Michele Cassano, Antonio Moffa, Vittorio Rinaldi,
Frontal sinus mucocele with intra-orbital extension represents a rare benign cyst-like lesion. Surgical management could be summarized in an open approach, an endoscopic marsupialization or a combined procedure. The present study reports a case of frontal mucocele with wide intra-orbital invasion treated with endoscopic marsupialization assisted by an image-guided navigation system.A 34-year-old African male was referred to the otolaryngology clinic for unilateral supraorbital swelling and post- ...
Tópico(s): Oral and Maxillofacial Pathology
2019 - Elsevier BV | International Journal of Surgery Case Reports
Produção Nacional
Revisado por pares
Paolo Cassano, Marco Antônio Caldieraro, Richard J. Norton, David Mischoulon, Nhi‐Ha Trinh, Maren Nyer, Christina Dording, Michael R. Hamblin, Benjamin R. Campbell, Dan V. Iosifescu,
Background: Transcranial photobiomodulation (t-PBM) consists in the delivery of near-infrared light (NIR) to the scalp, directed to cortical areas of the brain. NIR t-PBM recently emerged as a potential therapy for depression, although safety of repeated treatments has not been adequately explored. Objective: This study assessed incidence of side effects, including weight and blood pressure changes, during repeated sessions of NIR t-PBM using a light-emitting diode source. Methods: We performed a ...
Tópico(s): Medical and Biological Ozone Research
2019 - Mary Ann Liebert, Inc. | Photobiomodulation Photomedicine and Laser Surgery
Antonio Cassano, Richard Marchese Robinson, Anna Palczewska, Tomasz Puzyn, Agnieszka Gajewicz, Lang Tran, Serena Manganelli, Mark T.D. Cronin,
Nanotechnology is one of the most important technological developments of the 21st century. In silico methods to predict toxicity, such as quantitative structure-activity relationships (QSARs), promote the safe-by-design approach for the development of new materials, including nanomaterials. In this study, a set of cytotoxicity experimental data corresponding to 19 data points for silica nanomaterials were investigated, to compare the widely employed CORAL and Random Forest approaches in terms of ...
Tópico(s): Nanoparticles: synthesis and applications
2016 - SAGE Publishing | Alternatives to Laboratory Animals
Annalisa Patrizi, Beatrice Raone, Iria Neri, Carlotta Gurioli, Monica Carbonara, Nicoletta Cassano, Gino Antonio Vena,
Introduction: This mono-center randomized, controlled, double-blind study evaluates the safety and efficacy of MD2011001 cream versus placebo, in mild-to-moderate atopic dermatitis (AD). MD2011001 is a nonsteroidal topical cream containing vitamin E, epigallocatechin gallate and grape seed procyanidins.Methods: Patients with AD (corresponding to an IGA score of 2 or 3), involving the face, the perioral/periocular area and/or the neck, were enrolled. Patients were randomized 1:1 ratio to receive MD2011001 ...
Tópico(s): Allergic Rhinitis and Sensitization
2015 - Informa | Journal of Dermatological Treatment
Claudia Cappelli, Antonio Cassano, Azadi Golbamaki, Y. Moggio, Anna Lombardo, Mauro Colafranceschi, Emilio Benfenati,
We evaluated the performance of eight QSAR in silico modelling packages (ACD/ToxSuite™, ADMET Predictor™, DEMETRA, ECOSAR, TerraQSAR™, Toxicity Estimation Software Tool, TOPKAT™ and VEGA) for acute aquatic toxicity towards two species of fish: Fathead Minnow and Rainbow Trout. For the Fathead Minnow, we compared model predictions for 567 substances with the corresponding experimental values for 96-h median lethal concentrations (LC50). Some models gave good results, with r2 up to 0.85. We also classified ...
Tópico(s): Pesticide Residue Analysis and Safety
2015 - Taylor & Francis | SAR and QSAR in environmental research
Antonio Cassano, Giuseppa Raitano, Enrico Mombelli, Alberto Fernández, Josep Cester, Alessandra Roncaglioni, Emilio Benfenati,
We evaluated the performance of seven freely available quantitative structure-activity relationship models predicting Ames genotoxicity thanks to a dataset of chemicals that were registered under the EU Registration, Evaluation, Authorization and Restriction of Chemicals (REACH) regulation. The performance of the models was estimated according to Cooper's statistics and Matthew's Correlation Coefficients (MCC). The Benigni/Bossa rule base originally implemented in Toxtree and re-implemented within ...
Tópico(s): Environmental Toxicology and Ecotoxicology
2014 - Taylor & Francis | Journal of Environmental Science and Health Part C
Azadi Golbamaki, Antonio Cassano, Anna Lombardo, Y. Moggio, Mauro Colafranceschi, Emilio Benfenati,
AbstractEight in silico modelling packages were evaluated and compared for the prediction of Daphnia magna acute toxicity from the viewpoint of the European legislation on chemicals, REACH. We tested the following models: Discovery Studio (DS) TOPKAT, ACD/Tox Suite, ADMET Predictor™, ECOSAR (Ecological Structure Activity Relationships), TerraQSAR™, T.E.S.T. (Toxicity Estimation Software Tool) and two models implemented in VEGA on 480 industrial compounds for 48-h median lethal concentrations (LC50) ...
Tópico(s): Chemistry and Chemical Engineering
2014 - Taylor & Francis | SAR and QSAR in environmental research
Rosa Capozzo, Vitaliano Nicola Quaranta, Fabio Pellegrini, Andrea Fontana, Massimiliano Copetti, Pierluigi Carratù, Francesco Panza, Anna Cassano, Vito Antonio Falcone, Rosanna Tortelli, Rosa Cortese, Isabella Laura Simone, Onofrio Resta, Giancarlo Logroscino,
Tópico(s): Dysphagia Assessment and Management
2014 - Springer Science+Business Media | Journal of Neurology
Nazanin Golbamaki, Bakhtiyor Rasulev, Antonio Cassano, Richard Marchese Robinson, Emilio Benfenati, Jerzy Leszczyński, Mark T.D. Cronin,
An increasing number of publications report genotoxicity studies for metal oxide and silica nanomaterials which may induce different kinds of genotoxicity via a variety of mechanisms.
Tópico(s): Environmental Toxicology and Ecotoxicology
2014 - Royal Society of Chemistry | Nanoscale