Eva Recio, Juan Macı́as, Antonio Rivero‐Juárez, Francisco Téllez, Dolores Merino, MJosé Ríos, Manuel Márquez, Mohamed Omar, Antonio Rivero, Sandra Lorenzo, Nicolás Merchante, Juan A. Pineda,
... Jaen, SpainSearch for more papers by this authorAntonio Rivero, Antonio Rivero Unit of Infectious Diseases, Maimonides Institute for ... Jaen, SpainSearch for more papers by this authorAntonio Rivero, Antonio Rivero Unit of Infectious Diseases, Maimonides Institute for Biomedical ...
Tópico(s): Hepatitis C virus research
2012 - Wiley | Liver International
José Miguel Cisneros, Francisco Pozo, Raquel Serrano, Elisa Vidal, Antonio Rivero, Antônio Tenório,
... Cisneros Francisco Pozo Raquel Serrano Elisa Vidal Antonio Rivero Antonio Tenorio
Tópico(s): Cytomegalovirus and herpesvirus research
2000 - Lippincott Williams & Wilkins | AIDS
Marı́a Casares-Jiménez, Tránsito García‐García, José M. Suárez-Cárdenas, Ana Belén Pérez, M.A. Martı́n, Javier Caballero‐Gómez, Carmen Michán, Diana Corona‐Mata, María Á. Risalde, Ignacio Valero, Rafael Guerra, Ignacio García‐Bocanegra, Antonio Rivero, António Rivero‐Juarez, Juan J. Garrido,
Wastewater pathogen monitoring is useful for surveillance of enteric pathogens. Information about the presence of Paslahepevirus balayani (HEV) and emergent Rocahepevirus ratti (RHEV) in untreated water and their correlation with clinical cases is scarce. Aim To longitudinally monitor HEV and RHEV in wastewater and to evaluate their possible correlation with human cases.This study was carried out in the city of Cordoba (southern Spain) from March 2021 to March 2023. HEV and RHEV occurrence were evaluated ...
Tópico(s): Viral Infections and Immunology Research
2023 - Elsevier BV | The Science of The Total Environment
Pedro López‐López, María Á. Risalde, Mario Frías, Ignacio García‐Bocanegra, Teresa Brieva, Javier Caballero‐Gómez, Ángela Camacho, Vicente Fernández‐Molera, Isabel Machuca, J.C. Gómez-Villamandos, Antonio Rivero, António Rivero‐Juarez,
Pigs are considered important reservoirs of HEV and so constitute a major risk of transmission to humans, either via direct contact or by consuming raw or undercooked contaminated pork products. Once the scale of this disease on European pig farms has been estimated, the identification of risk factors associated with HEV infection in these species could help determine contingency strategies to minimize the risk of transmission to humans. Our objective was to evaluate risk factors associated with ...
Tópico(s): Veterinary medicine and infectious diseases
2018 - Elsevier BV | Veterinary Microbiology
Mario Frías, Pedro López‐López, Antonio Rivero, António Rivero‐Juarez,
Chronic liver disease (CLD) with a variety of causes is currently reported to be one of the main causes of death worldwide. Patients with CLD experience deteriorating liver function and fibrosis, progressing to cirrhosis, chronic hepatic decompensation (CHD), end-stage liver disease (ESLD), and death. Patients may develop acute-on-chronic liver failure (ACLF), typically related to a precipitating event and associated with increased mortality. The objective of this review was to analyze the role of acute ...
Tópico(s): Liver Disease Diagnosis and Treatment
2018 - Hindawi Publishing Corporation | BioMed Research International
Francisca Cuenca-López, Antonio Rivero, Antonio Rivero‐Juárez,
The sofosbuvir (SOF) plus ledipasvir (LDV) fixed dose combination is the first direct action antiviral (DAA) single-treatment regimen (STR) to be commercialized. It is approved for the treatment of Hepatitis C virus (HCV) genotypes 1,3,4,5 and 6. Following approval in 2014, new pharmacokinetics and pharmacodynamics data were reported, which led to important clinical applications. Areas covered: This article reviews the pharmacokinetic and pharmacodynamic properties of the SOF/LDV fixed dose combination ...
Tópico(s): Systemic Lupus Erythematosus Research
2016 - Taylor & Francis | Expert Opinion on Drug Metabolism & Toxicology
Nicolás Merchante, Antonio Rivero‐Juárez, Francisco Téllez, Dolores Merino, Maria José Ríos-Villegas, Marina Villalobos, Mohamed Omar, Pilar Rincón, Antonio Rivero, Montserrat Pérez‐Pérez, Miguel Raffo, Inmaculada López-Montesinos, Rosario Palacios, María Amparo Gómez-Vidal, Juan Macı́as, Juan A. Pineda, Nicolás Merchante, Pilar Rincón, Marı́a José Iglesias, Luís Miguel Real, Juan Macı́as, Juan A. Pineda, Antonio Rivero Juárez, Teresa Brieva, Ángela Camacho Espejo, Antonio Rivero, Francisco Téllez, Dolores Merino, Miguel Raffo, Maria José Riós Villegas, Inmaculada López-Montesinos, Marina Villalobos, Rosario Palacios, Jesús Santos, Mohamed Omar, Maria A Gómez Vidal, Monserrat Pérez Pérez,
To assess the impact of all-oral direct-acting antiviral agent (DAA) regimens on the risk of hepatocellular carcinoma (HCC) in HIV/HCV-coinfected patients with cirrhosis. This was a multicentre prospective cohort study recruiting HIV/HCV-coinfected patients with a new diagnosis of compensated cirrhosis. Patients were followed up until HCC, death or the censoring date (March 2017). The primary endpoint was the emergence of HCC. The incidence rate (IR) (95% CI) of HCC in different groups was computed. ...
Tópico(s): Liver Disease and Transplantation
2018 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Lucía Ríos-Muñoz, Moisés Gonzálvez, Javier Caballero‐Gómez, Sabrina Castro‐Scholten, Marı́a Casares-Jiménez, Irene Agulló‐Ros, Diana Corona‐Mata, Ignacio García‐Bocanegra, Pedro López‐López, T. T. Fajardo, João R. Mesquita, María Á. Risalde, António Rivero‐Juarez,
Abstract We identified rat hepatitis E virus (HEV) RNA in farmed pigs from Spain. Our results indicate that pigs might be susceptible to rat HEV and could serve as viral intermediaries between rodents and humans. Europe should evaluate the prevalence of rat HEV in farmed pigs to assess the risk to public health.
Tópico(s): Liver Disease and Transplantation
2024 - Centers for Disease Control and Prevention | Emerging infectious diseases
Karin Neukam, J Mira, Josefa Ruiz‐Morales, A. Rivero, Antonio Collado, Almudena Torres-Cornejo, Dolores Merino, Ignacio de los Santos, Juan Macı́as, Mercedes González‐Serrano, Ángela Camacho, Ginés David Parra-García, Juan A. Pineda, António Rivero‐Juarez, Inés Pérez‐Camacho, Julián Torre‐Cisneros, A. Aliaga-Jimenez, Luís F. López‐Cortés, Rosario Palacios-Muñoz, J. Santos-Gonzalez, Manuel Márquez, Enrique Nuño-Álvarez, Antonio Fernández,
To compare the frequency of grade 3 or 4 transaminase elevations (TEs) in HIV/hepatitis C virus (HCV) co-infected patients who started a three-antiretroviral drug regimen including efavirenz or a ritonavir-boosted protease inhibitor (PI/r) and the influence of pre-existing significant hepatic fibrosis or cirrhosis. All pre-treated or treatment-naive HIV/HCV co-infected patients who started an antiretroviral regimen including two nucleos(t)ide reverse transcriptase inhibitors along with efavirenz or ...
Tópico(s): HIV Research and Treatment
2011 - Oxford University Press | Journal of Antimicrobial Chemotherapy
Karin Neukam, Jacob Nattermann, Norma Rallón, Antonio Rivero, Antonio Carúz, Juan Macı́as, M. Vogel, José M. Benito, Ángela Camacho, J. A. Mira, Carolynne Schwarze‐Zander, Pablo Barreiro, A. Martínez, JK Rockstroh, Vincent Soriano, Juan A. Pineda,
The C allele of the single nucleotide polymorphism rs12979860, located near the interleukin-28B (IL-28B) gene, has a strong impact on hepatitis C virus (HCV) treatment response, as well as on spontaneous viral clearance. In patients with chronic hepatitis C (CHC), genotype CC carriers harbour HCV genotype 3 more commonly than those with non-CC genotypes. The aim of this study was to compare the HCV genotype distributions, according to IL-28B genotype, in HIV-infected patients with CHC and those with ...
Tópico(s): Liver Disease Diagnosis and Treatment
2011 - Wiley | HIV Medicine
José Antonio López Mira, Luís F. López‐Cortés, Dolores Merino, Ana Arizcorreta-Yarza, Antonio Rivero, Antonio Collado, Maria José Ríos-Villegas, Mercedes González‐Serrano, M. Torres-Tortosa, Juan Macı́as, B. Valera-Bestard, Elisa Fernández-Fuertes, J.A. Girón González, Fernando Lozano, Juan A. Pineda,
Haematological adverse events related to pegylated interferon (PEG-IFN) and ribavirin (RBV) therapy could affect the patients' quality of life; however, the risk factors for severe haematological toxicity associated with this therapy in patients coinfected with hepatitis C virus (HCV) and HIV are unclear. The objective of this study was to identify predictors of severe haematological toxicity among HIV-HCV-coinfected patients treated with PEG-IFN plus RBV.This retrospective multicentric study included ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2007 - SAGE Publishing | Antiviral Therapy
Federico Pulido, Esteban Ribera, María Lagarde, Ignacio Valero, Rosario Palacios, José Antonio Iribarren, Antoni Payeras, Peré Domingo, José Sanz, Miguel Cervero, Adrián Curran, Francisco Javier Rodríguez‐Gómez, María Jesús Téllez, Pablo Ryan, Pilar Barrufet, Hernando Knobel, Antonio Rivero, Belén Alejos, María Yllescas, José Ramón Arribas, José Ramón Arribas, Rocío Montejano, Juan González‐García, Marisa Montes, José Ignacio Bernardino, Ignacio Valero, Juan Castro, Mario Mayoral, Federico Pulido, María Lagarde, Otilia Bisbal, Mariano Matarranz, Asunción Hernando, Lourdes Domínguez, Rafael Rubio, Esteban Ribera, Adrián Curran, Jordi Navarro, Joaquín Burgos, I Ocaña, Vicenç Falcó, José Ramón Santos, Rosario Palacios, Ignacio Pérez, Carmen María González-Domenech, Maialen Ibarguren, Miguel Ángel Goenaga, Francisco Rodríguez-Arrondo, M. A. von Wichmann, Xabier Kortajarena, M.P. Carmona, H Son Llatzer, Antoni Payeras, Maison Abu Raya, Andrea Salom, Peré Domingo, María Luisa Navarro Gómez, M. Gracia Mateo, M. A. Sambeat, José Sanz, J. de Miguel, E Casas, Alberto Arranz, Miguel Cervero, Rafael Torres, H Infanta Elena, Francisco Javier Rodríguez‐Gómez, J M Fajardó, Francisco Javier Martínez‐Marcos, María de la Paz Valverde Merino, Miguel Raffo, Ignacio Suárez-Lozano, H. Clínico, María Jesús Téllez, Jorge Vergas, Vicente Estrada, H Infanta Leonor, Pablo Ryan, Jesús Troya, Guillermo Cuevas, Victorino Diez-Viñas, Tamar Talaván, F Solís, H de Mataró, Pilar Barrufet, Lluís Force, Hanna Mar, Hernando Knobel, A. M. Maceira Gonzalez, Edgar V. Lerma, J. Villar, H Reina Sofía, Antonio Rivero, Ángela Camacho, Isabel Machuca, Teresa Brieva, Antonio Rivero‐Juárez, JM Gatell, R. Domínguez, Daniel Podzamczer, Eva Van den Eynde, Laura Acerete, Andrés Navarro‐Ruiz, María Silvana DiYacovo, H Virgen de las Nieves, Juan Pasquau, Coral García, J.E. Losa, C Henríquez, Joaquín Portilla, Livia Giner, Irene Portilla, M. Pampliega, Vicente Boix, Esperanza Merino, Sergio Reus, Diego Torrús, Bonaventura Clotet, Eugènia Negredo, A Chamarro, Patricia Corbasi, Desiré Gil‐Pérez, Piedad Arazo, FranciscoJosé Parras, Margarita Ramírez, I Gutiérrez-Cuéllar, H Son Espases, Melchor Riera, L Gil-Alonso, Helem Vílchez, María Yllescas, Belén Alejos, E. Ubiña Aznar, Herminia Esteban, P González, Socorro Gonzalez, Marta de Miguel,
Our objective was to assess the therapeutic noninferiority of dual therapy with darunavir/ritonavir and lamivudine compared to triple therapy with darunavir/ritonavir plus 2 nucleos(t)ides for maintenance of human immunodeficiency virus type 1 (HIV-1) suppression.This was a multicenter, open-label, noninferiority trial (margin 12%). Patients with HIV-1 RNA <50 copies/mL for 6 months or longer on triple therapy with darunavir/ritonavir and 2 nucleos(t)ides (tenofovir disoproxil fumarate and emtricitabine ...
Tópico(s): HIV/AIDS Research and Interventions
2017 - Oxford University Press | Clinical Infectious Diseases
Mario Frías, Pedro López‐López, Ismael Zafra, Javier Caballero‐Gómez, Isabel Machuca, Ángela Camacho, María Á. Risalde, Antonio Rivero‐Juárez, Antonio Rivero,
The objective of this study was to design a pangenotypic PCR-based assay for the detection and quantification of hepatitis E virus (HEV) RNA from across the entire spectrum of described genotypes belonging to the Orthohepevirus A genus. The optimal conditions and the performance of the assay were determined by testing the WHO standard strain (6219/10) and the WHO HEV panel (8578/13). Similarly, performance comparisons were made with two commercial assays (Real Star HEV RT-PCR 2.0 and ampliCube HEV 2. ...
Tópico(s): Liver Disease and Transplantation
2020 - American Society for Microbiology | Journal of Clinical Microbiology
Marı́a Casares-Jiménez, Pedro López‐López, Javier Caballero‐Gómez, Mario Frías, Belen Perez-Hernando, Adeolu Sunday Oluremi, María Á. Risalde, Inmaculada Ruiz-Caceres, Oluyinka Oladele Opaleye, Ignacio García‐Bocanegra, António Rivero‐Juarez, Antonio Rivero,
Our study aim was to describe and characterize the global Hepatitis E virus (HEV) molecular and genotype geographical distribution in domestic pig and wild boar, which could facilitate the traceability of human cases. We performed a systematic sequence search for HEVs identified in domestic pig and wild boar from the available data in GenBank. Only sequences with lengths greater than 300 nt were included. For all sequences, the sequence length, host (i.e., domestic pig or wild boar), country of origin, ...
Tópico(s): Viral gastroenteritis research and epidemiology
2021 - Elsevier BV | One Health
Antonio Rivero‐Juárez, Antonio Aguilera, Ana Avellón, Miguel García Deltoro, Féderico García, Christian Gortázar, Rafael Granados, Juan Macı́as, Nicolás Merchante, José A. Oteo, María Teresa Pérez‐Gracia, Juan A. Pineda, Antonio Rivero, David Rodríguez‐Lázaro, Francisco Téllez, Luís Morano,
Hepatitis E virus (HEV) infection is one of the main causes of acute hepatitis in both developed and developing countries. This infectious disease has a high prevalence and incidence in Europe. HEV infection has a greater clinical impact in vulnerable populations, such as immunosuppressed patients, pregnant women and patients with underlying liver disease. Therefore, the Study Group for Viral Hepatitis (Grupo de Estudio de Hepatitis Víricas, GEHEP) of the Spanish Society of Infectious Diseases and ...
Tópico(s): Viral gastroenteritis research and epidemiology
2018 - Elsevier BV | Enfermedades Infecciosas y Microbiología Clínica
Carmen Gasca‐Capote, Xiaodong Lian, Ce Gao, Isabelle Roseto, María Reyes Jiménez‐León, Gregory T. Gladkov, María Inés Camacho-Sojo, Alberto Pérez‐Gómez, Isabel Gallego, Luis Eduardo López-Cortés, Sara Bachiller, Joana Vitallé, Mohammed Rafii‐El‐Idrissi Benhnia, Francisco José Ostos, Antonio Collado, Jesús Santos, Rosario Palacios, Cristina Gómez‐Ayerbe, Leopoldo Muñoz‐Medina, Andrés Ruiz-Sancho, Mario Frías, Antonio Rivero‐Juárez, Cristina Roca-Oporto, Carmen Hidalgo‐Tenorio, Anna Rull, Julián Olalla, Miguel Ángel López‐Ruz, Francesc Vidal, Consuelo Viladés, Andrea Mastrángelo, Matthias Cavassini, Núria Espinosa, Matthieu Perreau, Joaquín Peraire, Antonio Rivero, Luís F. López‐Cortés, Mathias Lichterfeld, Xu G. Yu, Ezequiel Ruiz‐Mateos,
Background: Persistent controllers (PC) maintain antiretroviral-free HIV-1 control indefinitely over time while transient controllers (TC) eventually lose virological control. It is essential to characterize the quality of the HIV reservoir of these phenotypes to identify the factors that lead to HIV progression and to open new avenues in HIV cure strategies. Methods: The characterization of HIV-1 reservoir, from peripheral blood mononuclear cells, was performed using next-generation sequencing techniques, ...
Tópico(s): Cytomegalovirus and herpesvirus research
2024 - American Society for Clinical Investigation | Journal of Clinical Investigation
Teresa Brieva, Antonio Rivero, Antonio Rivero‐Juárez,
Introduction: The fixed-dose combination therapy of sofosbuvir (SOF) plus velpatasvir (VEL) is the first pangenotypic, direct-acting antiviral (DAA), single-treatment regimen (STR) for the treatment of hepatitis C virus (HCV) infection to be commercialized. It is approved for the treatment of HCV genotypes 1, 2, 3, 4, 5, and 6. Following approval in 2016, new pharmacokinetic and pharmacodynamic data were reported, which led to important clinical applications.Areas covered: This review provides a summary ...
Tópico(s): Liver Disease Diagnosis and Treatment
2017 - Taylor & Francis | Expert Opinion on Drug Metabolism & Toxicology
Luís Miguel Real, Rocío Herrero, António Rivero‐Juarez, Ángela Camacho, Juan Macı́as, Sandra Vic, Vincent Soriano, Sergio Viedma, Josep M. Guardiola, Joan Fibla, Antonio Rivero, Juan A. Pineda, Antonio Carúz,
The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments. The role of this polymorphism in HIV-1 infection is controversial. We investigated whether genetic variation at IFNL4 is associated to HIV-1 acquisition. The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype ...
Tópico(s): HIV Research and Treatment
2015 - Lippincott Williams & Wilkins | AIDS
Javier Caballero‐Gómez, Saúl Jiménez‐Ruiz, Pedro López‐López, Joaquín Vicente, María Á. Risalde, David Cano‐Terriza, Mario Frías, José Á. Barasona, Antonio Rivero, Ignacio García‐Bocanegra, António Rivero‐Juarez,
Wild boar (Sus scrofa) is considered as the main wildlife reservoir of zoonotic hepatitis E virus (HEV) genotypes. The aim of this study was to evaluate the circulation of HEV in free-ranging wild boar in the Doñana National Park (DNP), Spain. Blood samples were collected from 99 wild boar in the DNP during 2015. Sera were analysed in parallel using indirect ELISA and real-time RT-PCR. A total of 57 of the 99 tested animals (57.6%; 95%CI: 47.8%–67.3%) had anti-HEV antibodies, indicating that this virus ...
Tópico(s): Viral gastroenteritis research and epidemiology
2019 - Wiley | Transboundary and Emerging Diseases
Inés Suárez‐García, Belén Alejos, Víctoria Hernando, Laura Viñuela, Mar Vera, David Rial‐Crestelo, Maria Jesús Pérez‐Elías, Helena Iglesias, Joaquim Peraire, Juan Tiraboschi, Asunción Díaz, Santiago Moreno, Inmaculada Jarrín, Santiago Moreno, Inmaculada Jarrín, David Dalmau, Marta Navarro, Maria Gonzalez, Féderico García, Eva Poveda, José Antonio Iribarren, Félix Gutiérrez, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, María Ángeles Muñoz‐Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Jorge del Romero Raposo, Cristina Marco, Julián Puente, María Ángeles Muñoz‐Fernández, Elba Mauleón, Roxana Juárez, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez‐Payá, Juan Carlos Rodrı́guez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrús, Verónica Álvarez, Julia Portilla, María Remedios Alemán Valls, Jehovana Hernández, Ana López Lirola, Dácil García, Felícitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, Víctor Asensi, M Eugenia Rivas, Tomás Suárez‐Zarracina, Eulalia Valle-Garay, Javier Arias‐Díaz, Federico Pulido, Rafael Rubio, Otilia Bisbal, M. Asunción Hernando, David Rial, María Lagarde, Octavio Arce, Adriana Pinto, Laura Muñoz Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, José Antonio Iribarren, María José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, Ma Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Félix Gutiérrez, Mar Masiá, Catalina Robledano, Sergio Padilla, Javier García Abellán, Paula Mascarell, Araceli Adsuar, Rafael J. Pascual, Mar Carvajal, Marta Fernández, José Alberto García, Ángela Botella, Alba de la Rica, Carolina Ding, Lidia García-Sánchez, Nuria Ena, Xavier Barber, Vanessa Agullo, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Leandro López, Jennifer Vallejo, Nieves Gonzalo-Jiménez, Montserrat Ruiz, Antonio Galiana, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Juan Carlos López Bernaldo de Quirós, Isabel Gutiérrez, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldámiz‐Echevarría, Francisco Tejerina, Cristina Díez, Leire Pérez, Chiara Fanciulli, Saray Corral, Joaquín Peraire, Anna Martí, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García‐Pardo, Frederic Gómez, Sonia Espineira, Marta Montero, Marino Blanes, María Tasias, Eva Muñoz, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González‐García, Ana Delgado‐Hierro, José Ramón Arribas, Víctor Arribas, José Ignacio Bernardino, Carmen Busca, Joanna Cano, Julen Cadiñanos, Juan Castro, Luis Escosa, Iker Falces, Pedro Herranz, Víctor Hontañón, Milagros García, A. M. Maceira Gonzalez, Luz Martín‐Carbonero, Mario Mayoral, Ma José Mellado, Rafael Micán, Rosa de Miguel Buckley, Rocío Montejano, Marisa Montes, V. Moreno, Luis Ramos Berta Rodés, Talía Sainz, Elena Sendagorta, Eulalia Valencia, José Ramón Blanco, Laura Pérez‐Martínez, José A. Oteo, Valvanera Ibarra, Luís Metola, Mercedes Sanz, Rosa Martı́nez, Gloria Sampériz, David Dalmau, Marina Martínez, Ángeles Jaén, Mireia Cairó, Javier Martínez‐Sanz, Roser Font, Laura Gisbert, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Pilar Rivero Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaró, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García‐Fraile, Enrique García Martín, Ildefonso Sánchez‐Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santiago Moreno, Santos del Campo, José L. Casado, Fernando Dronda, Ana Moreno, María Jesús Pérez-Granda, Sergio E. Serrano, María Jesús Vivancos, Javier Martínez‐Sanz, Alejandro Vallejo, Matilde Sanchez, José A. Pérez‐Molina, José Manuel Hermida, Enrique Bernal, Antonia Alcaraz, Joaquín Bravo Urbieta, Ángeles Muñoz, C. Tomás, Mónica Martínez, M. Carmen Villalba, Féderico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Luz Pintos Peñaranda, Ma Angels Ribas, Antoni A Campins, Mercedes Garcia-Gazalla, Francisco Fanjul, Javier Murillas, Francisco Homar, Helem Vílchez, Luisa Martín, Antoni Payeras, Jesús Santos, María López, Cristina Gómez, Isabel Viciana, Rosario Palacios, Luís F. López‐Cortés, Núria Espinosa, Cristina Roca-Oporto, Silvia Llaves, Juan Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquín Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchíz, Lucía Rodríguez, Julián Olalla, Matilde Sanchez, Javiér Pérez, Alfonso del Arco,
Abstract Objectives To assess the effectiveness and tolerability of dolutegravir (DTG)/lamivudine (3TC) among treatment-naive and virologically suppressed treatment-experienced individuals in the multicentre cohort of the Spanish HIV/AIDS Research Network (CoRIS) during the years 2018–2021. Methods We used multivariable regression models to compare viral suppression (VS) [HIV RNA viral load (VL) <50 copies/mL] and the change in CD4 cell counts at 24 and 48 (±12) weeks after initiation with dolutegravir/ ...
Oxford University Press
António Rivero‐Juarez, Mario Frías, Antonio Martínez-Peinado, María Á. Risalde, Diego Rodríguez-Cano, Ángela Camacho, Ignacio García‐Bocanegra, Francisca Cuenca-López, J.C. Gómez-Villamandos, Antonio Rivero,
Summary An HIV‐infected patient was diagnosed with acute hepatitis E infection in our hospital. An epidemiological inquiry was performed to collect demographic, food and animal exposure variables in order to identify the potential route of transmission. The patient reported that his family traditionally hunted wild boar for food. All family members were analysed for hepatitis E virus infection. Additionally, route of transmission by wild boar meat consumption and prevalence of HEV infection among ...
Tópico(s): Liver Disease and Transplantation
2017 - Wiley | Zoonoses and Public Health
Juan A. Pineda, Celia Cifuentes, Manuel Parra, Nicolás Merchante, Elisabet Pérez-Navarro, Antonio Rivero‐Juárez, Patricia Monje, Antonio Rivero, Juan Macı́as, Luís Miguel Real,
To know the prevalence, incidence and factors associated with hepatitis E virus (HEV) infection in HIV-infected individuals in Spain, as well as to provide information on the natural history of HIV/HEV coinfection.Prospective cohort study.Serum HEV IgG antibodies were tested in 613 HIV-infected patients at baseline and 2 years thereafter. Positive samples were tested for HEV-RNA. In patients with seroconversion, changes in liver function tests, serum HEV IgM antibodies and HEV RNA in samples collected ...
Tópico(s): Liver Disease and Transplantation
2014 - Lippincott Williams & Wilkins | AIDS
Luís Miguel Real, Karin Neukam, Rocío Herrero, Josep M. Guardiola, Thomas Reiberger, Antonio Rivero‐Juárez, Juliana Salazar, Mattias Mandorfer, Dolores Merino, Vincent Soriano, Antonio Rivero, Juan Macı́as, Juan A. Pineda, Antonio Carúz,
Objectives The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV in Caucasian HCV-1/4-infected individuals and to compare its performance with that of rs12979860. ...
Tópico(s): Liver Disease Diagnosis and Treatment
2014 - Public Library of Science | PLoS ONE
António Rivero‐Juarez, Loreto Martinez‐Dueñas, Antonio Martínez-Peinado, Ángela Camacho, Celia Cifuentes, Ana Gordon, Mario Frías, José Miguel Cisneros, Juan A. Pineda, Antonio Rivero,
Background & aims The seroprevalence of the hepatitis E virus (HEV) and its chronicity rate in the HIV-infected population has not been well established. As a result, the magnitude of this emerging disease in this population cannot be established. Methods Prospective study that included HIV-infected patients followed up between September 2012 and May 2013. All included patients were tested for anti-HEV IgG/IgM. In patients with confirmed anti-HEV IgG/IgM positivity, RT-PCR was performed. In patients ...
Tópico(s): Viral gastroenteritis research and epidemiology
2014 - Elsevier BV | Journal of Infection
Sara Corchado, Luís F. López‐Cortés, António Rivero‐Juarez, Almudena Torres-Cornejo, Antonio Rivero, Mercedes Márquez-Coello, J.A. Girón González,
Objective To establish the role of liver fibrosis as a predictive tool of response to pegylated interferon alpha (Peg-IFN) and ribavirin (RBV) treatment in human immunodeficiency (HIV)/hepatitis C virus (HCV) coinfected patients, in addition to recognized predictive factors (HCV load, HCV genotype, IL-28B polymorphism). Patients and Methods A sample of 267 HIV/HCV coinfected patients was treated with Peg-IFN and RBV. Predictive factors of rapid (RVR) and sustained (SVR) virological response were analyzed. ...
Tópico(s): Hepatitis B Virus Studies
2014 - Public Library of Science | PLoS ONE
Antonio Antela, Antonio Rivero, Josep M. Llibre, Santiago Moreno, Antonio Antela, Josep M. Llibre, Santiago Moreno, Antonio Rivero, Marta Montero, Enrique Bernal, José Ramón Blanco Ramos, Manuel Castaño, David Dalmau Juanola, Belén de la Fuente García, Carlos Dueñas, Núria Espinosa, Vicente Estrada, M. Puerto, Miguel García del Toro, Juan González, Miguel Górgolas, Carmen Hidalgo-Tenorio, Hernando Knobel Freu, Juan Carlos López Bernaldo de Quirós, Juan Macías Sánchez, C. Ruiz, E. Martínez Chamorro, Mar Masiá, M. Rodríguez Miguélez, Celia Miralles, Julián Olalla, Esteban Ribera, Francisco Félix Rodríguez-Vidigal, Rafael Rubio, Santos Jesús,
Thanks to advances in the field over the years, HIV/AIDS has now become a manageable chronic condition. Nevertheless, a new set of HIV-associated complications has emerged, related in part to the accelerated ageing observed in people living with HIV/AIDS, the cumulative toxicities from exposure to antiretroviral drugs over decades and emerging comorbidities. As a result, HIV/AIDS can still have a negative impact on patients' quality of life (QoL). In this scenario, it is reasonable to believe that ...
Tópico(s): HIV Research and Treatment
2021 - Oxford University Press | Journal of Antimicrobial Chemotherapy
António Rivero‐Juarez, Pedro López‐López, Mario Frías, Antonio Rivero,
The hepatitis E virus (HEV) represents a major cause of acute hepatitis worldwide. The majority of HEV cases occur in low-income countries, mainly Asia and Africa, where HEV causes large outbreaks associated with the consumption of contaminated water and high mortality in specific populations. In high-income countries, HEV infection is considered a zoonotic disease that is linked to the consumption of contaminated food. Although a high proportion of cases have self-limiting asymptomatic or subclinical ...
Tópico(s): Viral gastroenteritis research and epidemiology
2019 - Frontiers Media | Frontiers in Microbiology
Juan A. Pineda, Antonio Carúz, Federico A. Di Lello, Ángela Camacho, Pilar Mesa, Karin Neukam, Antonio Rivero‐Juárez, Juan Macı́as, Jesús Gómez‐Mateos, Antonio Rivero,
The aims of this study were to appraise the predictive value of variations in a single-nucleotide polymorphism (SNP) in the low-density lipoprotein receptor (LDLR) gene for sustained virological response (SVR) to pegylated interferon (Peg-IFN) and ribavirin (RBV), as well as to analyze the relationship between LDLR genotype and other predictors of SVR, particularly IL28B genotype, in patients coinfected with HIV and hepatitis C virus (HCV).One hundred and eighty-four HIV/HCV-coinfected, treatment-naive ...
Tópico(s): HIV Research and Treatment
2011 - Lippincott Williams & Wilkins | AIDS
Karin Neukam, Daniela Munteanu, António Rivero‐Juarez, Thomas A. Lutz, Jan Fehr, Mattias Mandorfer, Sanjay Bhagani, Luís F. López‐Cortés, Annette Haberl, Marcel Stoeckle, Manuel Márquez, Stefan Scholten, Ignacio de los Santos, Stefan Mauss, Antonio Rivero, Antonio Collado, Marcial Delgado, Juergen Rockstroh, Juan A. Pineda,
Background and Aims Clinical trials of therapy against chronic hepatitis C virus (HCV) infection including boceprevir (BOC) or telaprevir (TVR) plus pegylated interferon and ribavirin (PR) have reported considerably higher response rates than those achieved with PR alone. This study sought to evaluate the efficacy and safety of triple therapy including BOC or TVR in combination with PR in HIV/HCV-coinfected patients under real-life conditions. Methods In a multicentre study conducted in 24 sites throughout ...
Tópico(s): Liver Disease Diagnosis and Treatment
2015 - Public Library of Science | PLoS ONE
Javier Caballero‐Gómez, Sara Pereira, Irene Rivero‐Calle, Ana B. Perez, Isabel Viciana, Marı́a Casares-Jiménez, Lucía Ríos-Muñoz, António Rivero‐Juarez, Antonio Aguilera, Antonio Rivero,
Two of 11 children with acute hepatitis of unknown origin were found to have rat hepatitis E virus infection. This infection should be considered in the differential diagnosis of children with acute hepatitis of unknown origin.
Tópico(s): Viral gastroenteritis research and epidemiology
2024 - Elsevier BV | The Journal of Pediatrics