Sara Campos, N. Silva, Armando Carvalho,
The inability to distinguish cancer (CSCs) from normal stem cells (NSCs) has hindered attempts to identify safer, more effective therapies for hepatocellular carcinoma (HCC). The aim of this study was to document and compare cell membrane potential differences (PDs) of CSCs and NSCs derived from human HCC and healthy livers respectively and determine whether altered GABAergic innervation could explain the differences.Epithelial cell adhesion molecule (EpCAM) positive stem cells were isolated from human ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2017 - Elsevier BV | Annals of Hepatology
Produção Nacional
Revisado por pares
Leonel Carvalho, Armando M. Leite da Silva, Vladimiro Miranda,
This paper proposes a new optimization tool based on the cross-entropy (CE) method to assess security-constrained optimal power flow (SCOPF) solutions. First, the corresponding SCOPF stochastic problem is defined so that the optimum solution is interpreted as a rare event to be reached by a random search. Second, the CE method solves this new problem efficiently by making adaptive changes to the probability density function according to the Kullback-Leibler distance, creating a sequence of density ...
Tópico(s): Power System Reliability and Maintenance
2018 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Diogo Amorim, Irma da Silva Brito, Armando Caseiro, João Paulo Figueiredo, André Luíz de Carvalho Braule Pinto, I Joana Macedo, Jorge Machado,
The estimated number of people living with anxiety disorders worldwide is around 264 million and is estimated to have worsened with the recent pandemic of COVID-19. Acupuncture has shown to have excellent therapeutic effects in reducing anxiety. Double-blinded randomized controlled clinical trial with 56 participants (21–82 years) with anxiety diagnosed by 3 different anxiety scales (BAI, GAD-7 and OASIS). A 30-min acupuncture session was applied once a week for 10 weeks. Evaluate the effectiveness ...
Tópico(s): Complementary and Alternative Medicine Studies
2022 - Elsevier BV | Complementary Therapies in Clinical Practice
Bernardete Ribeiro, Catarina Silva, Armando Vieira, João Carvalho das Neves,
In the recent financial crisis the incidence of important cases of bankruptcy led to a growing interest in corporate bankruptcy prediction models. In addition to building appropriate financial distress prediction models, it is also of extreme importance to devise dimensionality reduction methods able to extract the most discriminative features. Here we show that Non-Negative Matrix Factorization (NMF) is a powerful technique for successful extraction of features in this financial setting. NMF is ...
Tópico(s): Cognitive Computing and Networks
2009 - Springer Science+Business Media | Lecture notes in computer science
Produção Nacional
Revisado por pares
Maria Alayde M. da Silva, Iván Romero Rivera, Antônio Carlos C. Carvalho, Armando de Holanda Guerra Júnior, Tereza Cristina de A. Moreira,
OBJETIVO: Identificar a prevalência do hábito de fumar e a ocorrência de variáveis associadas ao hábito em crianças e adolescentes de 7 a 17 anos, de ambos os sexos e provenientes da cidade de Maceió. MÉTODOS: Estudo epidemiológico transversal, baseado na população de alunos da rede de ensino público e privada, níveis fundamental e médio. Cálculo da amostra baseado na menor prevalência esperada de inúmeras variáveis, incluindo tabagismo. Amostragem por conglomerados. Questionário sobre o hábito ...
Tópico(s): Injury Epidemiology and Prevention
2006 - Elsevier BV | Jornal de Pediatria
Produção Nacional
Revisado por pares
Mayara Gomes Corrêa, Camilla Ferreira Rodrigues e Silva, Lucas Antunes Dias, Sérgio da Silva Rocha, Freddy R. Thomes, Luiz Alberto do Lago, Armando de Mattos Carvalho, Rafael Resende Faleiros,
Horse confinement is a common practice worldwide. However, preventing horses from grazing and denying them social interaction can compromise their welfare and lead to undesirable consequences. Considering the hypothesis that increasing the forage consumption time can lead to improved welfare, the objective of this study was to verify the effect of the implementation of a slow-feeder hay bag on the ethogram, motor activity, heart rate, and cortisol circadian rhythm (CCR) of stabled horses. Seven healthy ...
Tópico(s): Exercise and Physiological Responses
2020 - Elsevier BV | Journal of Veterinary Behavior
Produção Nacional
Revisado por pares
Vladimiro Miranda, Leonel Carvalho, Mauro Augusto da Rosa, Armando M. Leite da Silva, Chanan Singh,
This paper presents an application of evolutionary particle swarm optimization (EPSO)-based methods to evaluate power system reliability. Population-based (PB) methods appear as competitors to the traditional Monte Carlo simulation (MCS), because they are computationally efficient in estimating a variety of reliability indices. The work reported in this paper demonstrates that EPSO variants can focus the search in the region of the state space where contributions to the formation of a reliability index ...
Tópico(s): Optimal Power Flow Distribution
2009 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Produção Nacional
Revisado por pares
Leonel Carvalho, Reinaldo A. Gonzalez-Fernandez, Armando M. Leite da Silva, Mauro Augusto da Rosa, Vladimiro Miranda,
This paper presents a new algorithm to estimate the optimal importance sampling (IS) probability distribution in generating capacity reliability (GCR) problems. The proposed approach results from a combination of the cross-entropy (CE) concepts with the standard analytical GCR assessment. A mathematical analysis of the CE equations is carried out to demonstrate that the optimal change of measure or distortion can be obtained by simply dividing the annualized GCR indices for two different configurations ...
Tópico(s): Probabilistic and Robust Engineering Design
2013 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Produção Nacional
Revisado por pares
Daiane S. Carvalho, Danilo G. B. da Silva, Fernando Hallwass, Armando Navarro‐Vázquez,
Chemically cross-linked polyacrylontrile polymer gels, have been prepared as an alignment medium compatible with DMSO-d6. These gels allow measurement of residual dipolar couplings (RDCs) and residual chemical shift anisotropies (RCSAs) with good accuracy as tested with brucine and α-santonin natural compounds. The gels can be reversibly compressed allowing easy measurement of RCSAs. They also present good physical homogeneity, clean HSQC spectra with little background 1H signals, and allow unambiguous ...
Tópico(s): Protein Structure and Dynamics
2019 - Elsevier BV | Journal of Magnetic Resonance
Produção Nacional
Revisado por pares
Leonel Carvalho, Mauro Augusto da Rosa, Armando M. Leite da Silva, Vladimiro Miranda,
This paper presents a sequential Monte Carlo simulation algorithm that can simultaneously assess composite system adequacy and detect wind power curtailment events. A simple procedure at the end of the state evaluation stage is proposed to categorize wind power curtailment events according to their cause. Furthermore, the dual variables of the DC optimal power flow procedure are used to identify which transmission circuits are restricting the use of the total wind power available. In the first set ...
Tópico(s): Optimal Power Flow Distribution
2012 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Systems
Produção Nacional
Revisado por pares
Maria Alayde M. da Silva, Iván Romero Rivera, Antônio Carlos C. Carvalho, Armando de H. Guerra Júnior, Tereza Cristina de A. Moreira,
Tópico(s): Obesity, Physical Activity, Diet
2006 - Elsevier BV | Jornal de Pediatria
Adélia Simão, João Madaleno, N. Silva, Fernando Rodrigues, Paula Caseiro, Nascimento Costa, Armando Carvalho,
Implementation of surveillance programs for at-risk populations and identification of biomarkers for early hepatocellular carcinoma (HCC) detection are a major public health goal. Recently, osteopontin (OPN) has attracted attention as a promising biomarker, with some potential advantages compared to alpha-fetoprotein (AFP), but its role in the context of alcoholic cirrhosis has never been assessed. The aims of this study are to assess the utility of plasma OPN in the diagnosis of HCC in alcoholic cirrhotic ...
Tópico(s): Bone and Dental Protein Studies
2015 - BioMed Central | BMC Gastroenterology
Bernardete Ribeiro, Catarina Silva, Ning Chen, Armando Vieira, João Carvalho das Neves,
Default risk models have lately raised a great interest due to the recent world economic crisis. In spite of many advanced techniques that have extensively been proposed, no comprehensive method incorporating a holistic perspective has hitherto been considered. Thus, the existing models for bankruptcy prediction lack the whole coverage of contextual knowledge which may prevent the decision makers such as investors and financial analysts to take the right decisions. Recently, SVM+ provides a formal ...
Tópico(s): Data Mining Algorithms and Applications
2012 - Elsevier BV | Expert Systems with Applications
Produção Nacional
Maurício Oliveira Magalhães, Luzilauri Harumi Muzi, Josielli Comachio, Thomaz Nogueira Burke, Fábio Jorge Renovato França, Luiz Armando Vidal Ramos, Gabriel Peixoto Leão Almeida, Ana Paula Carvalho‐e‐Silva, Amélia Pasqual Marques,
Chronic low back pain is one of the most common problematic health conditions worldwide and is highly associated with disability, quality of life, emotional changes, and work absenteeism. Graded activity programs, based on cognitive behavioral therapy, and exercises are common treatments for patients with low back pain. However, recent evidence has shown that there is no evidence to support graded activity for patients with chronic nonspecific low back pain.to compare the effectiveness of graded ...
Tópico(s): Myofascial pain diagnosis and treatment
2015 - Elsevier BV | Manual Therapy
Patrícia R. Pinto, Ana Cristina Paredes, Pedro Silva Moreira, Susana Fernandes, Marcelo Lopes, Margarida Carvalho, Armando Almeida,
Introduction Haemophilia is related to several clinical and psychosocial challenges that have been associated with increased emotional distress. These may impact on disease adjustment and health outcomes, reinforcing the attention given to psychosocial health of people with haemophilia ( PWH ), in the scope of optimal comprehensive care. Aim To identify potentially modifiable factors associated with the presence of anxiety and depression symptoms among adult PWH . Methods This was a cross‐sectional observational ...
Tópico(s): Hemophilia Treatment and Research
2018 - Wiley | Haemophilia
Produção Nacional
Revisado por pares
J. G. S. Santos, M.A. Corrêa, Armando Ferreira, Bruno R. Carvalho, Rodolfo Bezerra da Silva, F. Bohn, S. Lanceros‐Méndez, F. Vaz,
Multifunctional and multiresponsive thin films are playing an increasing role in modern technology. This work reports a study on the magnetic properties of ZnO and Ag-doped ZnO semiconducting films prepared with a zigzag-like columnar architecture and their correlation with the processing conditions. The films were grown through Glancing Angle Deposition (GLAD) co-sputtering technique to improve the induced ferromagnetism at room temperature. Structural and morphological characterizations have been ...
Tópico(s): Copper-based nanomaterials and applications
2020 - Multidisciplinary Digital Publishing Institute | Materials
Bernardete Ribeiro, Armando Vieira, João Duarte, Catarina Silva, João Carvalho das Neves, Qingzhong Liu, Andrew H. Sung,
We apply manifold learning to a real data set of distressed and healthy companies for proper geometric tunning of similarity data points and visualization. While Isomap algorithm is often used in unsupervised learning our approach combines this algorithm with information of class labels for bankruptcy prediction. We compare prediction results with classifiers such as Support Vector Machines (SVM), Relevance Vector Machines (RVM) and the simple k-Nearest Neighbor (KNN) in the same data set and we show ...
Tópico(s): Data Mining Algorithms and Applications
2009 - Springer Science+Business Media | Lecture notes in computer science
Produção Nacional
Revisado por pares
Alexandra A.P. Mansur, Sandhra M. Carvalho, Zélia Inês Portela Lobato, Maria de Fátima Leite, Armando Silva‐Cunha, Herman S. Mansur,
Polymer-drug conjugation is an attractive approach for target delivering insoluble and highly toxic drugs to tumor sites to overcome the side-effects caused by cancer chemotherapy. In this study we designed and synthesized novel polymer-drug-peptide conjugates for improved specificity on targeting cancer cells. Chemically modified polysaccharide, carboxymethylcellulose (CMC), was conjugated with doxorubicin (DOX) anticancer drug by amide bonds and dually biofunctionalized with integrin-target receptor ...
Tópico(s): Cell Adhesion Molecules Research
2018 - American Chemical Society | Bioconjugate Chemistry
Mariana Verdelho Machado, Sara Policarpo, J. Coutinho, Sofia Carvalhana, Jorge Leitão, Armando Carvalho, Ana Paula Silva, Francisco Velasco, Isabel Medeiros, Ana Catarina Alves, Mafalda Bourbon, Helena Cortez‐Pinto,
Tópico(s): Liver Disease and Transplantation
2019 - Springer Science+Business Media | Obesity Surgery
Produção Nacional
Revisado por pares
Mariana Bezamat, Juliana Feltrin de Souza, Fernanda Mafei Félix da Silva, Emilly Godinho Corrêa, Aluhê Lopes Fatturi, João Armando Brancher, Flávia Martinez de Carvalho, Tayla Cavallari, Laís Bertolazo, Cleber Machado‐Souza, Mine Koruyucu, Merve Bayram, Andrea Racic, Benjamin Harrison, Yan Y. Sweat, Ariadne Letra, Deborah Studen‐Pavlovich, Figen Seymen, Brad A. Amendt, Renata Iani Werneck, Marcelo C. Costa, Adriana Modesto, Alexandre R. Vieira,
Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur when there are disturbances during the mineralization or maturation stage of amelogenesis. Both genetic and environmental factors have been suggested to play roles in MIH’s development, but no conclusive risk factors have shown the source of the ...
Tópico(s): Oral microbiology and periodontitis research
2021 - Public Library of Science | PLoS ONE
Fábio Jorge Renovato França, Bianca Callegari, Luiz Armando Vidal Ramos, Thomaz Nogueira Burke, Maurício Oliveira Magalhães, Josielli Comachio, Ana Paula Carvalho‐e‐Silva, Gabriel Peixoto Leão Almeida, Amélia Pasqual Marques,
Objective The aim of the study was to compare the effectiveness of motor control training and transcutaneous electrical nerve stimulation in relieving pain, reducing functional disability, and improving transversus abdominis activation in patients with lumbar disc herniation with associated radiculopathy. Design This is a randomized controlled trial. Methods Forty patients diagnosed with lumbar disc herniation were randomly divided into two groups: motor control training group ( n = 20) and transcutaneous ...
Tópico(s): Myofascial pain diagnosis and treatment
2018 - Lippincott Williams & Wilkins | American Journal of Physical Medicine & Rehabilitation
Produção Nacional
Revisado por pares
Vanessa Guimarães Alves Olher, Alan G. Souza, Lucas Ulisses Rovigatti Chiavelli, Ana Lúcia Tasca Góis Ruiz, João Ernesto de Carvalho, Armando M. Pomini, Cleuza C. Silva,
The cultivation of sugarcane hybrids (X Saccharum officinarum L.) is an important revenue source for the Brazilian economy. Herein it is reported the evaluation of the cytotoxic activity of mid-polarity sugarcane extracts against human cancer cell lines, as well as the isolation of steroids sitosterol, stigmasterol and campesterol, phenolic acids p-hydroxybenzoic, p-hydroxycinnamic, vanillic and ferulic acid, terpenoids α-tocopherol and β-carotene and a novel substance in sugarcane, the flavonoid ...
Tópico(s): Phytochemistry and Bioactive Compounds
2016 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Mariana Luís, Luísa Brites, Bruno Fernandes, Diogo Jesús, Tânia Santiago, Sara Serra, João Rovisco, Lina Carvalho, José António Pereira da Silva, Armando Malcata,
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2018 - Springer Science+Business Media | Rheumatology International
Produção Nacional
Revisado por pares
Bruna Tássia dos Santos Pantoja, Armando Reinaldo Marques Silva, Renata Mondêgo‐Oliveira, Thamires Santos da Silva, Babara Carvalho Marques, Rafaela Pontes de Albuquerque, Joicy Cortez de Sá Sousa, Rose Elí Grassi Rici, María Angélica Miglino, Alana Lislea de Sousa, André Luis R. Franciolli, Eduardo Martins de Sousa, Ana Lúcia Abreu‐Silva, Rafael Cardoso Carvalho,
Background and Aim: From a biomedical point of view, the value of marsupials as a model of primitive mammals is indisputable. Among its species, the possum is a model that allows the study of the ontogeny of different organic systems, as well as their physiological aspects. The relevance of anatomical, functional, evolutionary, and phylogenetic study of marsupials for the development of comparative morphology is extensively documented in the literature. However, there are still many aspects to be ...
Tópico(s): Meat and Animal Product Quality
2020 - Veterinary World | Veterinary World
Joana Duarte, Ana Tavares e Castro, Raquel Silva, Lurdes Correia, Adélia Simão, Armando Carvalho,
Introduction: Plasma D-dimer (DD) levels are among the potential new biomarkers for patients with community-acquired pneumonia (CAP). The aim of this study was to investigate the relationship between serum DD levels and the severity of CAP, assessed by CURB-65 and PSI scores, radiological extent of the disease and mortality. Material and Methods: Prospectively analysis of adult patients with CAP, admitted to our Internal Medicine ward between 18 th of December 2013 and 30 th of April 2014. Standard ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2015 - Elsevier BV | Revista Portuguesa de Pneumologia
Produção Nacional
Revisado por pares
Hugo Shisei Toma, José Victor Pronievicz Barreto, Alexandre Mendes Amude, Cláudia Dias Monteiro Toma, Armando de Mattos Carvalho, Luciano da Silva Cabral, T.C.P. Munhoz, Simone Fernanda Nedel Pértile, Luiz Fernando Coelho da Cunha Filho,
ABSTRACT This study characterized the clinical, radiological, ultrasound, and necroscopic findings of a case of Arnold-Chiari type II malformation in a Gir breed calf from Brazil. The animal was hospitalized at sixty days of age, in permanent sternal recumbency, cutaneous appendix at the 4th lumbar vertebra and kyphoscoliosis of the caudal and lumbosacral thoracic spine. Radiographic examination of the spine and skull revealed spina bifida and suspected occipital hypoplasia. Upon examination of ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2021 - UNIVERSIDADE FEDERAL DE MINAS GERAIS | Arquivo Brasileiro de Medicina Veterinária e Zootecnia
Produção Nacional
Revisado por pares
Fernanda de Paula Araújo, Ricardo Diego Duarte Galhardo de Albuquerque, Leonardo da Silva Rangel, Gabriel Rocha Caldas, Luís Armando Cândido Tietbohl, Marcelo Guerra Santos, Eduardo Ricci‐Júnior, Silvana Carvalho Thiengo, Mônica Ammon Fernandez, José Augusto Albuquerque dos Santos, Robson Xavier Faria, Leandro Rocha,
BACKGROUND This work describes a chemical study of the essential oil from leaves of Xylopia ochrantha, an endemic Annonaceae species from Brazil, and its activity against Biomphalaria species. Considering its poor solubility in aqueous medium, the essential oil was nanoemulsified to evaluate its action on controlling some mollusc species of genus Biomphalaria, snail hosts of Schistosoma mansoni that causes schistosomiasis, which mainly affects tropical and subtropical countries. OBJECTIVES The main ...
Tópico(s): Moringa oleifera research and applications
2019 - Instituto Oswaldo Cruz, Ministério da Saúde | Memórias do Instituto Oswaldo Cruz
Produção Nacional
Revisado por pares
Luiz Armando Vidal Ramos, Bianca Callegari, Fábio Jorge Renovato França, Maurício Oliveira Magalhães, Thomaz Nogueira Burke, Ana Paula Carvalho‐e‐Silva, Gabriel Peixoto Leão Almeida, Josielli Comachio, Amélia Pasqual Marques,
Objective The purpose of this study was to compare transcutaneous electrical nerve stimulation (TENS) and stabilization exercises in an attempt to prevent fatigue and improve muscle activation in patients with lumbar disk herniation associated with low back pain. Methods This study involved 29 patients (age range 25-58 years) randomized into 2 groups: the segmental stabilization group (n = 15), who received stabilization exercises on the transversus abdominis (TrA) and lumbar multifidus muscles; and the ...
Tópico(s): Spine and Intervertebral Disc Pathology
2018 - Elsevier BV | Journal of Manipulative and Physiological Therapeutics
M. Bessa da Silva, Nélson Abrantes, Teresa Rocha‐Santos, Armando C. Duarte, Ana C. Freitas, Ana Gomes, Ana P. Carvalho, João Carlos Marques, Fernando Gonçalves, Ruth Pereira,
Risk assessment of pesticides has been based on direct toxic effects on aquatic organisms. Indirect effects data are taken into account but with limitations, as it is frequently difficult to predict their real impacts in the ecosystems. In this context the main aim of this work was to assess how the exposure to the herbicide pendimethalin (Prowl(®)), under environmentally relevant concentrations, may compromise the nutritional composition of food for a relevant group of primary consumers of freshwater ...
Tópico(s): Pesticide and Herbicide Environmental Studies
2016 - Elsevier BV | Aquatic Toxicology
Produção Nacional
Revisado por pares
Filipe Dwan Pereira, Elaine Oliveira, David Braga Fernandes de Oliveira, Alexandra I. Cristea, Leandro Silva Galvão de Carvalho, Samuel C. Fonseca, Armando M. Toda, Seiji Isotani,
Abstract Tools for automatic grading programming assignments, also known as Online Judges, have been widely used to support computer science (CS) courses. Nevertheless, few studies have used these tools to acquire and analyse interaction data to better understand the students’ performance and behaviours, often due to data availability or inadequate granularity. To address this problem, we propose an Online Judge called CodeBench, which allows for fine‐grained data collection of student interactions, ...
Tópico(s): Educational Games and Gamification
2020 - Wiley | British Journal of Educational Technology