A. Ritter, David L. Gally, Peter Olsen, Ulrich Dobrindt, Arne Friedrich, Per Klemm, Jörg Hacker,
The uropathogenic Escherichia coli strain 536 (O6:K15: H31) carries two large chromosomal pathogenicity islands (Pais). Both Pais are flanked by tRNA genes. Spontaneous deletion of Pai II results in truncation of the leuX tRNA Leu 5 gene. This tRNA is required for the expression of type 1 fimbriae (Fim) and other virulence factors. Transcription of fimA , encoding the major type 1 fimbrial subunit is controlled by an invertable DNA switch. The inversion is catalysed by two recombinases, FimB and FimE. ...
Tópico(s): Bacterial Genetics and Biotechnology
1997 - Wiley | Molecular Microbiology
J. Wiedersich, Simone Köhler, Arne Skerra, J. Friedrich,
We have measured the equilibrium constant for the denaturation transition of the engineered fluorescein-binding lipocalin FluA as a function of pressure and temperature, taking advantage of the fact that the ligand's fluorescence is almost fully quenched when complexed with the folded protein, but reversibly reappears on denaturation. From the equilibrium constant as a function of pressure and temperature all of the involved thermodynamic parameters of protein folding, in particular the changes ...
Tópico(s): Enzyme Structure and Function
2008 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Uwe Weidner, S S Geier, Arne Ptock, Thorsten Friedrich, Hans Leif, Hanns Weiss,
The gene locus nuo of the proton-translocating NADH : ubiquinone oxidoreductase in Escherichia coli was identified by means of a DNA probe made by the polymerase chain reaction. The primers used for the reaction were derived from consensus sequences of the NAD(H)-binding subunit of mitochondrial NADH : ubiquinone oxidoreductase and the NAD+-reducing hydrogenase of Alcaligenes eutrophus. The nuo locus lies between minutes 49·2 and 49·6 on the E. coli chromosome and contains a cluster of 14 genes. They ...
Tópico(s): Metabolism and Genetic Disorders
1993 - Elsevier BV | Journal of Molecular Biology
Milton Friedman, Leonard J. Savage,
... 146144482210839.https://doi.org/10.1177/14614448221083903Daniel Stockemer, Arne Niemann, Doris Unger, Friedrich Plank Equally at risk? Perceived financial differences, risk ...
Tópico(s): Decision-Making and Behavioral Economics
1948 - University of Chicago Press | Journal of Political Economy
Andreas Oberbach, Nadine Schlichting, Jochen Neuhaus, Yvonne Kullnick, Stefanie Lehmann, Marco Heinrich, Arne Dietrich, Friedrich W. Mohr, Martin von Bergen�, Sven Baumann,
Multiple reaction monitoring (MRM)-based mass spectrometric quantification of peptides and their corresponding proteins has been successfully applied for biomarker validation in serum. The option of multiplexing offers the chance to analyze various proteins in parallel, which is especially important in obesity research. Here, biomarkers that reflect multiple comorbidities and allow monitoring of therapy outcomes are required. Besides the suitability of established MRM assays for serum protein quantification, ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2014 - American Chemical Society | Journal of Proteome Research
Karsten Richter, Arne Jepsen, Friedrich Marks,
A pig-skin preparation enriched in epidermal G1-chalone when administered to cells of the rat tongue epithelial line RTE2 at concentrations of 3–300 μg/ml (dry mass) caused a 60% reduction in cell number. Three other cell lines showed essentially no growth inhibition during chalone treatment. The kinetics of chalone inhibition were similar to those observed in mouse epidermis in vivo. Five hours after the addition of chalone preparation in fresh medium a decrease in the rate of DNA synthesis was ...
Tópico(s): Neuroscience and Neuropharmacology Research
1984 - Elsevier BV | Experimental Cell Research
Arne C. Bathke, Sarah Friedrich, Markus Pauly, Frank Konietschke, Wolfgang Staffen, Nicolas Strobl, Yvonne Höller,
To date, there is a lack of satisfactory inferential techniques for the analysis of multivariate data in factorial designs, when only minimal assumptions on the data can be made. Presently available methods are limited to very particular study designs or assume either multivariate normality or equal covariance matrices across groups, or they do not allow for an assessment of the interaction effects across within-subjects and between-subjects variables. We propose and methodologically validate a ...
Tópico(s): Optimal Experimental Design Methods
2018 - Taylor & Francis | Multivariate Behavioral Research
Thomas Friedrich, Arne Bochmann, J. Dinger, S. Teichert,
In this paper an alternative method of off-line Kikuchi pattern centre calibration and orientation mapping, utilising the cross-correlation between entire experimental patterns and dynamical simulated patterns is applied and evaluated. To demonstrate the improvement in angular resolution compared to Hough transform based methods, EBSD datasets of a silicon monocrystal were analysed using both, classical and the presented cross-correlation based method, which revealed significant enhancement of angular ...
Tópico(s): Optical measurement and interference techniques
2017 - Elsevier BV | Ultramicroscopy
P. Friedrich, Arne Sattler, Karin Müller, Mikalai Nienen, Petra Reinke, Nina Babel,
Host protection upon vaccination usually results from the complex interplay of humoral and cellular components of the immune system. Exploring hepatitis B surface antigen (HBsAg)-specific T cell responses and their correlation with humoral responses under immunosuppression, we analyzed 51 renal transplant recipients, differing in HBV vaccine-specific antibody titers (non [NRs]-, low [LRs]-, and high responders [HRs]) and in 22 healthy controls (HCs) in a cross-sectional study. HBsAg-specific T cells were ...
Tópico(s): Hepatitis C virus research
2015 - Elsevier BV | American Journal of Transplantation
Christian Friedrich, Arne Ring, Tobias Brand, Regina Sennewald, Eva U. Graefe-Mody, H.J. Woerle,
Tópico(s): Potassium and Related Disorders
2011 - Adis, Springer Healthcare | European Journal of Drug Metabolism and Pharmacokinetics
Andreas Itzek, Christine M. Gillen, Marcus Fulde, Claudia Friedrichs, Arne C. Rodloff, Gursharan S. Chhatwal, D. Patric Nitsche-Schmitz,
Oral streptococci are a heterogeneous group of human commensals, with a potential to cause serious infections. Activation of plasminogen has been shown to increase the virulence of typical human pathogenic streptococci such as S. pneumoniae. One important factor for plasminogen activation is the streptococcal α-enolase. Here we report that plasminogen activation is also common in oral streptococci species involved in clinical infection and that it depends on the action of human plasminogen activators. ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2010 - Public Library of Science | PLoS ONE
Claudia Friedrichs, Arne C. Rodloff, Gursharan S. Chhatwal, Wolfgang Schellenberger, Klaus Eschrich,
ABSTRACT Viridans streptococci (VS) are responsible for several systemic diseases, such as endocarditis, abscesses, and septicemia. Unfortunately, species identification by conventional methods seems to be more difficult than species identification of other groups of bacteria. The aim of the present study was to evaluate the use of cell matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF-MS) for the rapid identification of 10 different species of VS. A total of ...
Tópico(s): Streptococcal Infections and Treatments
2007 - American Society for Microbiology | Journal of Clinical Microbiology
... Dimanganese, or is Heterodinuclear Better? Arne Roth Dr., Arne Roth Dr. Institut für Anorganische und Analytische Chemie, Friedrich-Schiller-Universität Jena, Carl-Zeiss-Promenade 10, 07745 ... more papers by this author Arne Roth Dr., Arne Roth Dr. Institut für Anorganische und Analytische Chemie, Friedrich-Schiller-Universität Jena, Carl-Zeiss-Promenade 10, 07745 ...
Tópico(s): Metalloenzymes and iron-sulfur proteins
2008 - Wiley | Angewandte Chemie International Edition
Linus Kameni Monkam, Arne Graf von Schweinitz, Jens Friedrichs, Xin Gao,
Of cryogenic liquid hydrogen tanks for future airliners, their volumetric and gravimetric efficiencies, their robustness and their environmental adaptability are all strengthened via a novel thermal insulation concept proposed in this work. A conventional cryogenic tank is insulated either purely by a layer/layers of Polyurethane (PU) foam or by a vacuum-based multilayer insulation (MLI). In the new concept, an extra layer is inserted into the PU foam. The intermediate layer can be filled with liquid ...
Tópico(s): Advanced Battery Technologies Research
2022 - Elsevier BV | International Journal of Hydrogen Energy
Christian Weimar, Konstantinos Bilbilis, Jan Rekowski, T. Holst, Friedhelm Beyersdorf, Martin Breuer, Manfred Dahm, Anno Diegeler, Arne Kowalski, Sven Martens, Friedrich W. Mohr, Jiří Ondrášek, B. Reiter, P. Roth, Ralf Seipelt, Markus Siggelkow, Gustav Steinhoff, Anton Moritz, Mathias Wilhelmi, Gerhard Wimmer‐Greinecker, Hans‐Christoph Diener, Heinz Jakob, Claudia Ose, André Scherag, Stephan Knipp,
The optimal operative strategy in patients with severe carotid artery disease undergoing coronary artery bypass grafting (CABG) is unknown. We sought to investigate the safety and efficacy of synchronous combined carotid endarterectomy and CABG as compared with isolated CABG.Patients with asymptomatic high-grade carotid artery stenosis ≥80% according to ECST (European Carotid Surgery Trial) ultrasound criteria (corresponding to ≥70% NASCET [North American Symptomatic Carotid Endarterectomy Trial]) who ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2017 - Lippincott Williams & Wilkins | Stroke
Tom Schmidt-Braekling, Arne Streitbuerger, Georg Gosheger, Friedrich Boettner, Markus Nottrott, H. Ahrens, Ralf Dieckmann, Wiebke K. Guder, Dimosthenis Andreou, G Hauschild, Burkhard Moellenbeck, Wenzel Waldstein, Jendrik Hardes,
Tópico(s): Dental materials and restorations
2017 - Springer Science+Business Media | European Journal of Orthopaedic Surgery & Traumatology
Andrea Caiti, Knut Grythe, Jens M. Hovem, S. M. Jesus, Arne Lie, Andrea Munafò, Tor Arne Reinen, António Silva, Friedrich Zabel,
Underwater acoustic networks (UANs) are an emerging technology for a number of oceanic applications, ranging from oceanographic data collection to surveillance applications. However, their reliable usage in the field is still an open research problem, due to the challenges posed by the oceanic environment. The UAN project, a European-Union-funded initiative, moved along these lines, and it was one of the first cases of successful deployment of a mobile underwater sensor network integrated within ...
Tópico(s): Indoor and Outdoor Localization Technologies
2013 - Institute of Electrical and Electronics Engineers | IEEE Journal of Oceanic Engineering
Tim Ritter, Marcel Schwarz, Andreas Tockner, Friedrich Leisch, Arne Nothdurft,
Mapping of exact tree positions can be regarded as a crucial task of field work associated with forest monitoring, especially on intensive research plots. We propose a two-stage density clustering approach for the automatic mapping of tree positions, and an algorithm for automatic tree diameter estimates based on terrestrial laser-scanning (TLS) point cloud data sampled under limited sighting conditions. We show that our novel approach is able to detect tree positions in a mixed and vertically structured ...
Tópico(s): Forest Ecology and Biodiversity Studies
2017 - Multidisciplinary Digital Publishing Institute | Forests
Gerit Arne Linneweber, Mathis Winking, Karl‐Friedrich Fischbach,
Most animal tissues and organ systems are comprised of highly ordered arrays of varying cell types. The development of external sensory organs requires complex cell-cell communication in order to give each cell a specific identity and to ensure a regular distributed pattern of the sensory bristles. This involves both long and short range signaling mediated by either diffusible or cell anchored factors. In a variety of processes the heterophilic Irre Cell Recognition Module, consisting of the Neph- ...
Tópico(s): Neurobiology and Insect Physiology Research
2015 - Public Library of Science | PLoS ONE
Oliver Sass, Michael Heel, Iris Leistner, Florence Stöger, Karl‐Friedrich Wetzel, Arne Friedmann,
ABSTRACT Wildfires in the sub‐alpine belt of the Austrian Limestone Alps sometimes cause severe vegetation and soil destruction with increased danger of secondary natural hazards such as avalanches and debris flows. Some of the affected areas remain degraded to rocky slopes even decades after the fire, raising the question as to whether the ecosystems will ever be able to recover. The mean fire interval, the duration of recovery and the role of geomorphic processes for vegetation regeneration are ...
Tópico(s): Aeolian processes and effects
2012 - Wiley | Earth Surface Processes and Landforms
Meike Becker, Nils Andersen, Björn Fiedler, Peer Fietzek, Arne Körtzinger, Tobias Steinhoff, Gernot Friedrichs,
The role of the global surface ocean as a source and sink for atmospheric carbon dioxide and the flux strengths between the ocean and the atmosphere can be quantified by measuring the fugacity of CO 2 (ƒCO 2 ) as well as the dissolved inorganic carbon (DIC) concentration and its isotopic composition in surface seawater. In this work, the potential of continuous wave cavity ringdown spectroscopy ( cw ‐CRDS) for autonomous underway measurements of ƒCO 2 and the stable carbon isotope ratio of DIC [δ 13 C(DIC)] ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2012 - Wiley | Limnology and Oceanography Methods
K Mueller, Thomas Schachtner, Arne Sattler, Sarah Meier, Péter Friedrich, Hanna Trydzenskaya, Carl Hinrichs, Ralf Ulrich Trappe, Andreas Thiel, Petra Reinke, Nina Babel,
Background. Polyomavirus BK virus (BKV) infection represents a serious complication leading to BKV-associated nephropathy (BKVAN) and subsequent kidney graft loss in up to 10% of transplant patients. Cellular immunity is known to play a crucial role in the control of BKV replication. However, the knowledge on the BKV-T-cell response is limited: only two (VP1 and large T antigen) of six known BKV proteins were evaluated for their antigenicity so far. Methods. By using 10-color flow cytometry and newly ...
Tópico(s): Full-Duplex Wireless Communications
2010 - Wolters Kluwer | Transplantation
Oliver Sass, Arne Friedmann, G. Haselwanter, Karl‐Friedrich Wetzel,
We investigated the thickness and composition of five small alpine mires in Tyrol (Austria), performing a combination of conventional techniques (telescope rods, drilling) and geophysical methods. GPR surveys were carried out using 100 and 200 MHz antennas. Geoelectrical profiles supplemented the GPR at two sites; the 2D-surveys were enhanced by additional 1D-profiling. The aim was to achieve data on mire thickness, to cross-check the methods and to find reasons for different performance at the five ...
Tópico(s): Geophysical and Geoelectrical Methods
2009 - Elsevier BV | CATENA
Elias S.J. Arnér, Hakan Sarioglu, Friedrich Lottspeich, Arne Holmgren, August Böck,
Mammalian thioredoxin reductase (TrxR) catalyzes reduction of thioredoxin and many other substrates, and is a central enzyme for cell proliferation and thiol redox control. The enzyme is a selenoprotein and can therefore, like all other mammalian selenoproteins, not be directly expressed in Escherichia coli, since selenocysteine-containing proteins are synthesized by a highly species-specific translation machinery. This machinery involves a secondary structure, SECIS element, in the selenoprotein- ...
Tópico(s): Glutathione Transferases and Polymorphisms
1999 - Elsevier BV | Journal of Molecular Biology
Azizolah Rahimi-Barfeh, Christina Grothusen, Assad Haneya, J Schöttler, Arne M Eide, Maria Erdmann, Christine Friedrich, G. Hoffmann, Jochen Cremer, Felix Schoeneich,
Acute type A aortic dissection (AAD) is a life-threatening disorder with a high rate of mortality and complications. All cannulation techniques currently used to establish arterial flow for cardiopulmonary bypass are associated with a considerable risk of organ malperfusion, stroke, or access site trauma. Here, we report the impact of transatrial cannulation of the left ventricle on patient outcome after surgical treatment of AAD.Between 2010 and 2013, 46 patients underwent emergency surgery for ...
Tópico(s): Cardiac Valve Diseases and Treatments
2016 - Elsevier BV | The Annals of Thoracic Surgery
Thomas Först, B. Uhlig‐Laske, Arne Ring, Ulrike Graefe‐Mody, Christian Friedrich, K. Herbach, H.J. Woerle, Klaus A. Dugi,
Diabet. Med. 27, 1409–1419 (2010) Abstract Aims The efficacy and safety of the dipeptidyl peptidase‐4 inhibitor, linagliptin, added to ongoing metformin therapy, were assessed in patients with Type 2 diabetes who had inadequate glycaemic control (HbA 1c ≥ 7.5 to ≤ 10%; ≥58.5 to ≤85.8 mmol/mol) with metformin alone. Methods Patients ( n = 333) were randomized to receive double‐blind linagliptin (1, 5 or 10 mg once daily) or placebo or open‐label glimepiride (1–3 mg once daily). The primary outcome measure was ...
Tópico(s): Peptidase Inhibition and Analysis
2010 - Wiley | Diabetic Medicine
Friedrich Plank, Arne Niemann,
Employing an agent–principal perspective on EU conflict resolution and focusing on the politics of discretion, we argue that the context in which the agent acts affects the principal–agent relation. Our conceptualization draws on the agent's actions as a source of discretion, which can be either an unintentional product of the characteristics of the external environment in which the agent performs (structure-induced discretion) or a product of intentionally pursued agent action (interest-induced discretion). ...
Tópico(s): Global Financial Regulation and Crises
2017 - Springer International Publishing | Palgrave studies in European Union politics
Karl‐Friedrich Fischbach, Gerit Arne Linneweber, Till F. M. Andlauer, Alexander Hertenstein, Bernhard Bonengel, Kokil Chaudhary,
: One of the most challenging problems in developmental neurosciences is to understand the establishment and maintenance of specific membrane contacts between axonal, dendritic, and glial processes in the neuropils, which eventually secure neuronal connectivity. However, underlying cell recognition events are pivotal in other tissues as well. This brief review focuses on the pleiotropic functions of a small, evolutionarily conserved group of proteins of the immunoglobulin superfamily involved in cell ...
Tópico(s): Plant Molecular Biology Research
2009 - Taylor & Francis | Journal of Neurogenetics
Hannes Baumann, Hans‐Harald Hinrichsen, Christian Möllmann, Friedrich W. Köster, Arne M. Malzahn, Axel Temming,
Recruitment patterns of Baltic Sea sprat (Sprattus sprattus) were correlated to time series of (i) month- and depth-specific temperature conditions and (ii) larval drift patterns inferred from long-term Lagrangian particle simulations. From the latter, we derived an index that likely reflected the variable degree of annual larval transport from the central, deep spawning basins to the shallow coastal areas of the Baltic Sea. The drift index was significantly (P < 0.001) correlated to sprat recruitment ...
Tópico(s): Oceanographic and Atmospheric Processes
2006 - Canadian Science Publishing | Canadian Journal of Fisheries and Aquatic Sciences
Heidi Maurer, Arne Niemann, Friedrich Plank,
This special section seeks to extent our knowledge on teaching innovative methods in European Union (EU) Foreign Affairs in time of challenges, politicisation, and digitalisation. It shares the experience of established and early career colleagues on how they designed, implemented, and applied specific innovations in their teaching. The section focuses on these experiences and aims to provide guidance on how specific ideas were put into practice in a hand-on and reflective manner. It seeks to tip ...
Tópico(s): Security, Politics, and Digital Transformation
2020 - UACES | Journal of Contemporary European Research