Robert Ahrends, Asuka Ota, Kyle M. Kovary, Takamasa Kudo, Byung Ouk Park, Mary N. Teruel,
Cell fate control—a numbers game Precursor cells in adult mammalian tissues differentiate at very low rates; for example, only 10% of fat cells are replaced per year. If all precursor cells responded to the same threshold of stimulus, these low rates would not be possible. Noise in the system (variability in the abundance of key proteins in different cells) could allow only a few cells to differentiate, but then such variability would allow dedifferentiation as well, which is not observed. Ahrends ...
Tópico(s): Receptor Mechanisms and Signaling
2014 - American Association for the Advancement of Science | Science
Shuxun Ren, Gang Lü, Asuka Ota, Zhenqi Zhou, Thomas M. Vondriska, Timothy F. Lane, Yibin Wang,
We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress. In the present report, we found that the PP2Ce protein is highly expressed in lactating epithelium of the mammary gland. Loss of PP2Ce in vivo impairs physiological unfolded protein response (UPR) and induces stress kinase activation, resulting in ...
Tópico(s): Microbial Inactivation Methods
2014 - Public Library of Science | PLoS ONE
Gang Lü, Asuka Ota, Shuxun Ren, Sarah Franklin, Christoph Rau, Peipei Ping, Timothy F. Lane, Z. Hong Zhou, Karen Reue, Aldons J. Lusis, Thomas M. Vondriska, Yibin Wang,
The protein phosphatase 1-like gene (PPM1l) was identified as causal gene for obesity and metabolic abnormalities in mice. However, the underlying mechanisms were unknown. In this report, we find PPM1l encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (PP2Ce) and has specific activity to basal and ER stress induced auto-phosphorylation of Inositol-REquiring protein-1 (IRE1). PP2Ce inactivation resulted in elevated IRE1 phosphorylation and higher expression of XBP-1, CHOP, and ...
Tópico(s): Pancreatic function and diabetes
2013 - Elsevier BV | Molecular Metabolism
IRE1α is an endoplasmic reticulum (ER) localized signaling molecule critical for unfolded protein response. During ER stress, IRE1α activation is induced by oligomerization and autophosphorylation in its cytosolic domain, a process triggered by dissociation of an ER luminal chaperone, binding immunoglobulin-protein (BiP), from IRE1α. In addition, inhibition of a cytosolic chaperone protein Hsp90 also induces IRE1α oligomerization and activation in the absence of an ER stressor. Here, we report that ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2011 - Elsevier BV | Journal of Biological Chemistry
Asuka Ota, Jun Zhang, Peipei Ping, Jiahuai Han, Yibin Wang,
Rationale : p38 is an important stress activated protein kinase involved in gene regulation, proliferation, differentiation, and cell death regulation in heart. p38 kinase activity can be induced through canonical pathway via upstream kinases or by noncanonical autophosphorylation. The intracellular p38 kinase activity is tightly regulated and maintained at low level under basal condition. The underlying regulatory mechanism for canonical p38 kinase activation is well-studied, but the regulation of ...
Tópico(s): Enzyme Structure and Function
2010 - Lippincott Williams & Wilkins | Circulation Research
Susan Vahebi, Asuka Ota, Manxiang Li, Chad M. Warren, Pieter P. de Tombe, Yibin Wang, R. John Solaro,
Our objective in work presented here was to understand the mechanisms by which activated p38α MAPK depresses myocardial contractility. To test the hypothesis that activation of p38 MAPK directly influences sarcomeric function, we used transgenic mouse models with hearts in which p38 MAPK was constitutively turned on by an upstream activator (MKK6bE). These hearts demonstrated a significant depression in ejection fraction after induction of the transgene. We also studied hearts of mice expressing ...
Tópico(s): Cellular Mechanics and Interactions
2007 - Lippincott Williams & Wilkins | Circulation Research
Scherise Mitchell, Asuka Ota, William Foster, Bin Zhang, Zixing Fang, Shilpa M. Patel, Stanley F. Nelson, Steve Horvath, Yibin Wang,
Three major MAP kinase signaling cascades, ERK, p38, and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. To study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac-specific and temporally regulated expression of activated mutants of Ras, MAP kinase kinase (MKK)3, and MKK7, which are selective upstream activators for ERK, p38, ...
Tópico(s): Cardiac electrophysiology and arrhythmias
2005 - American Physical Society | Physiological Genomics
Asuka Ota, Kyle M. Kovary, Olivia H. Wu, Robert Ahrends, Wen‐Jun Shen, Maria José de Carvalho Costa, Brian J. Feldman, Fredric B. Kraemer, Mary N. Teruel,
Insulin resistance (IR) underlies metabolic disease. Visceral, but not subcutaneous, white adipose tissue (WAT) has been linked to the development of IR, potentially due to differences in regulatory protein abundance. Here we investigate how protein levels are changed in IR in different WAT depots by developing a targeted proteomics approach to quantitatively compare the abundance of 42 nuclear proteins in subcutaneous and visceral WAT from a commonly used insulin-resistant mouse model, Lepr(db/db), ...
Tópico(s): Metabolism, Diabetes, and Cancer
2015 - Elsevier BV | Journal of Lipid Research
Yu Hisano, Asuka Inoue, Kiyohito Taimatsu, Satoshi Ota, Rie Ohga, Hirohito Kotani, Michiko Muraki, Junken Aoki, Atsuo Kawahara,
The lipid mediator sphingosine‐1‐phosphate (S1P) regulates various physiological and pathological phenomena such as angiogenesis and oncogenesis. Secreted S1P associates with the G‐protein‐coupled S1P receptors (S1PRs), leading to the activation of downstream signaling molecules. In mammals, five S1prs have been identified and the genetic disruption of a single S1pr1 gene causes vascular defects. In zebrafish, seven s1prs have been isolated. We found that individual s1prs showed unique expression ...
Tópico(s): Lipid Membrane Structure and Behavior
2015 - Wiley | Genes to Cells
Kiyokazu Shirai, Genta Nagae, M. Seki, Yotaro Kudo, Asuka Kamio, Akimasa Hayashi, Atsushi Okabe, Satoshi Ota, Shuichi Tsutsumi, Takanori Fujita, Shogo Yamamoto, Ryo Nakaki, Yasuharu Kanki, Tsuyoshi Osawa, Yutaka Midorikawa, Keisuke Tateishi, Masao Ichinose, Hiroyuki Aburatani,
Abstract Ten‐eleven translocation 1 (TET1) is an essential methylcytosine dioxygenase of the DNA demethylation pathway. Despite its dysregulation being known to occur in human cancer, the role of TET1 remains poorly understood. In this study, we report that TET1 promotes cell growth in human liver cancer. The transcriptome analysis of 68 clinical liver samples revealed a subgroup of TET1 ‐upregulated hepatocellular carcinoma (HCC), demonstrating hepatoblast‐like gene expression signatures. We performed ...
Tópico(s): Cancer-related gene regulation
2021 - Wiley | Cancer Science
Shigeo Ishikawa, Masahiro Sugimoto, Kenichiro Kitabatake, Michael Tu, Ayako Sugano, Iku Yamamori, Asuka Iba, Kazuyuki Yusa, Miku Kaneko, Sana Ota, Kana Hiwatari, Ayame Enomoto, Masaru Tomita, Mitsuyoshi Iino,
Tópico(s): Advanced Chemical Sensor Technologies
2017 - Springer Science+Business Media | Amino Acids
Hirokazu Usui, Asuka Sato, Masayuki Ota, Jun‐ichiro Ikeda, Makio Shozu,
Complete hydatidiform moles (CHMs) are androgenetic and have a high rate of progression to gestational trophoblastic neoplasia (GTN). CHMs are negative when immunostained for p57KIP2 protein, the product of the maternally expressed gene on chromosome 11p15.5, whereas biparental partial hydatidiform moles and hydropic abortion are positive for p57KIP2. This study presents two cases of p57KIP2-positive androgenetic CHMs and explores the cause of this inconsistency.Androgenetic CHMs were diagnosed using ...
Tópico(s): Prenatal Screening and Diagnostics
2020 - Oxford University Press | American Journal of Clinical Pathology
Yuki Ota, Junichiro Kuroda, Asuka Yamaguchi, Atsushi Suzuki, Daisuke Araoka, Toyoho Ishimura, Hodaka Kawahata,
To enhance our understanding of the forcing factors of marine biological community structure in the Bay of Bengal, we studied proxies for biogenic carbonate and silicate production in the western Bay of Bengal and compared them with proxies for upper-ocean stratification and strength of the Indian summer monsoon (ISM). Specifically, we investigated the record in a sediment core from the western Bay of Bengal that extended to approximately 80 ky before the present (BP). The records of Globigerinoides ...
Tópico(s): Marine and coastal ecosystems
2019 - Elsevier BV | Palaeogeography Palaeoclimatology Palaeoecology
Nobuyuki Araki, Sonoko Misawa, Kazumoto Shibuya, Satoshi Ota, Takashi Oide, Asuka Kawano, Minako Beppu, Yukio Nakatani, Satoshi Kuwabara,
Calciphylaxis is a syndrome consisting of vascular calcification, thrombosis, and skin necrosis. The syndrome develops often in chronic hemodialysis patients. However, there have been several case reports on calciphylaxis in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome, a systemic disease associated with plasma cell dyscrasia and upregulation of vascular endothelial growth factor (VEGF). In 76 POEMS patients and 86 age- and gender-matched ...
Tópico(s): Parathyroid Disorders and Treatments
2016 - BioMed Central | Orphanet Journal of Rare Diseases
Yuki Ota, Hodaka Kawahata, Junichiro Kuroda, Asuka Yamaguchi, Atsushi Suzuki, Daisuke Araoka, Ayako Abe‐Ouchi, Yasuhiro Yamada, Akira Ijiri, Toshiya Kanamatsu, Masataka Kinoshita, Kyaw Moe, Weiren Lin, Saneatsu Saito, Yoshinori Sanada, Yohei Hamada, Yasuyuki Nakamura, Yuichi Shinmoto, Hung‐Yu Wu, Naokazu Ahagon, Kan Aoike, Koichi Iijima, Hideaki Machiyama, Maria Luisa Tejada, Keita Umetsu, Yoichi Usui, Yuzuru Yamamoto, Shuro Yoshikawa, F.J. Jiménez-Espejo, Satoru Haraguchi, Nobuharu Komai, Hisami Suga, Natsue Abe, Lallan P. Gupta, Takehiro Hirose, Yuka Masaki, Shun Nomura, Takamitsu Sugihara, Wataru Tanikawa, Yusuke Kubo, Lena Maeda, Sean Toczko,
Abstract Detailed reconstruction of Indian summer monsoons is necessary to better understand the late Quaternary climate history of the Bay of Bengal and Indian peninsula. We established a chronostratigraphy for a sediment core from Hole 19B in the western Bay of Bengal, extending to approximately 80 kyr BP and examined major and trace element compositions and clay mineral components of the sediments. Higher δ 18 O values, lower TiO 2 contents, and weaker weathering in the sediment source area during ...
Tópico(s): earthquake and tectonic studies
2018 - Wiley | Geochemistry Geophysics Geosystems
Toru Ueki, Motowo Mizuno, Shigeru Ota, Tsuneyoshi Ogawa, Hiroshi Matsushita, Daisuke Uchida, Norifumi Numata, Asuka Ueda, Yuuki Morimoto, Yoko Kominami, Shintaro Nanba, Manabu Kurome, Hirotoki Ohe, Masahiro Nakagawa, Yasuyuki Araki,
Peroral cholangioscopy (POCS) is useful for the diagnosis of various bile duct lesions. However, it is often difficult to obtain clear images because of bile or biliary sludge in the bile duct, even after vigorous irrigation of the bile duct with saline solution. Therefore, this study investigated whether inflation with carbon dioxide (CO(2)) yields clearer images of the bile duct than conventional saline solution irrigation during POCS.To evaluate the clinical utility and safety of CO(2) insufflation ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2010 - Elsevier BV | Gastrointestinal Endoscopy
Kenta Nakamura, Tomonori Yaguchi, Masashi Murata, Yosuke Ota, Asuka Mikoshiba, Yukiko Kiniwa, Ryuhei Okuyama, Yutaka Kawakami,
Abstract Programmed death 1 (PD‐1)/programmed death‐ligand 1 inhibitors are commonly used to treat various cancers, including melanoma. However, their efficacy as monotherapy is limited, and combination immunotherapies are being explored to improve outcomes. In this study, we investigated a combination immunotherapy involving an anti‐PD‐1 antibody that blocks the major adaptive immune‐resistant mechanisms, a BRAF inhibitor that inhibits melanoma cell proliferation, and multiple primary immune‐resistant ...
Tópico(s): CAR-T cell therapy research
2024 - Wiley | Cancer Science
Asuka Ota, Koji Sugitani, Makoto Watanabe,
Abstract We have searched 14 dense cores, 11 of which have literature distances of 150–350 pc, for T Tauri stars by using the Wide Field Grism Spectrograph 2 on the University of Hawaii 2.2 m telescope. As a result, we detected 50 H α emission stars including 24 newly found objects. Twelve out of these 50 stars have a distance of ∼190–370 pc, and 16 of them are within a distance of ∼460 pc. Seven of these 16 objects are newly found H α emission stars and would serve as new good targets for studying ...
Tópico(s): Astro and Planetary Science
2022 - IOP Publishing | Research Notes of the AAS
Mary N. Teruel, Robert Ahrends, Asuka Ota, Kyle M. Kovary, Byung Ouk Park,
Mammalian tissue size is maintained by slow replacement of aging cells. For adipocytes, key regulators of glucose and lipid metabolism, the renewal rate is only 10% per year. Here we use computational modeling, quantitative mass spectrometry (1) and single‐cell microscopy (2) to show that expression noise acts within a network of more than six positive feedbacks to permit pre‐adipocytes to differentiate at very low rates. This solves two fundamental opposing requirements: high cell‐to‐cell signal ...
Tópico(s): Single-cell and spatial transcriptomics
2014 - Wiley | The FASEB Journal
Asuka Ota, Kyle M. Kovary, Robert Ahrends, Wen‐Jun Shen, Fredric B. Kraemer, Mary N. Teruel,
Insulin resistance (IR) predisposes to type 2 diabetes and cardiovascular diseases. Adipose tissue regulates glucose and lipid metabolism, and adipocyte dysfunction is linked to the development of IR. Transcription factors are the major regulators of adipocyte function, but the profiling of nuclear proteins in IR adipocytes has never been done. Here, we used selective reaction monitoring mass spectrometry to quantitatively measure the expression levels of nuclear proteins relevant to adipocyte function ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2013 - Wiley | The FASEB Journal
p38α is one of well studied stress-induced protein kinases that allows cells to respond various stressors by transducing extracellular signals to the nucleus. Its activity has been associated with diverse cellular functions and cardimyopathy. In order to investigate p38α pathway in cardiomyocytes, FLAG-DNp38α protein complex from mice heart was co-immunoprecipitated using sepharose beads conjugated with anti-FLAG M2 antibody. Precipitated proteins were trypsinized and identified by LC/MS/MS. Included ...
Tópico(s): Computational Drug Discovery Methods
2007 - Elsevier BV | Journal of Cardiac Failure
Asuka Ota, Chenggong Zong, Peipei Ping, Jiahuai Han, Yibin Wang,
Tópico(s): Protein Tyrosine Phosphatases
2006 - Elsevier BV | Journal of Cardiac Failure
Tópico(s): Anesthesia and Neurotoxicity Research
1995 - SAGE Publishing | Journal of the Society for Gynecologic Investigation
Satoshi IZUMI, Tatsuya Nakatani, Niina OTA, Asuka Hatano, Kenta YAMAGIWA,
We have investigated the finite element modeling for the elevator wire rope 8×S(19) to reproduce the stiffnesses in both axial and radial directions. In order to validate the finite element calculation, compression test to measure the radial-direction stiffnesses of strand, fiver core and wire rope have been newly proposed. From the experimental result of strand, it is found that the radial-direction stiffness is greatly lower than axial-direction one and is affected by the contact situation between ...
Tópico(s): Power Line Inspection Robots
2021 - Japan Society Mechanical Engineers | Transactions of the JSME (in Japanese)
Yuki Katayama, Tadaaki Yamada, Kenji Morimoto, Hiroyuki Fujii, Satomi Morita, Keiko Tanimura, Takayuki Takeda, Asuka Okada, Shinsuke Shiotsu, Yusuke Chihara, Osamu Hiranuma, Takahiro Yamada, Takahiro Ota, Taishi Harada, Isao Hasegawa, Akihiro Yoshimura, Masahiro Iwasaku, Shinsaku Tokuda, Young Hak Kim, Koichi Takayama,
Tópico(s): Lung Cancer Diagnosis and Treatment
2023 - Elsevier BV | JTO Clinical and Research Reports
Asuka Sawai, Kayoko Tsuzuki, Masamitsu Yamauchi, Noriko Kimura, T Tsushima, Kana Sugiyama, Yumiko Ota, Shinya Sawai, Osamu Tochikubo,
This study aimed to investigate the influence of plasma free amino acids (PFAA) concentration changed during the menstrual cycle in women. In 21 healthy university students were recruited who have almost 28 days in menstrual cycle before 2 months diary and measured by basal body temperature. The subjects blood samples were collected in menstrual cycles; menstrual (the 3–5 days), follicular (the 8–11 days), ovulation, luteal-1(the 18–20 days), luteal-2(the 24–28days) among two menstrual cycles. The ...
Tópico(s): Biochemical effects in animals
2018 - Taylor & Francis | Biological Rhythm Research
Takeshi Unoki, Kei Hayashida, Yusuke Kawai, Shunsuke Taito, Morihide Ando, Yuki Iida, Fumihito Kasai, Tatsuya Kawasaki, Ryo Kozu, Yutaka Kondo, Masakazu Saitoh, Hideaki Sakuramoto, Nobuyuki Sasaki, Ryuichi Saura, Kensuke Nakamura, Akira Ouchi, Saiko Okamoto, Masatsugu Okamura, Tomoki Kuribara, Akira Kuriyama, Yujiro Matsuishi, Norimasa Yamamoto, Shodai Yoshihiro, Taisuke Yasaka, Ryo Abe, Takahito Iitsuka, Hiroyasu Inoue, Yuki Uchiyama, Satoshi Endo, Kazuki Okura, Kohei Ota, Takahisa Otsuka, Daisuke Okada, Kengo Obata, Yukiko Katayama, Naoki Kaneda, Mio Kitayama, Shunsuke Kina, Ryuichi Kusaba, Masanari Kuwabara, Naoki Sasanuma, Masahiro Takahashi, Chihiro Takayama, N. Tashiro, Junko Tatsuno, Takahiko Tamura, Mitsuhiro Tamoto, Asuka Tsuchiya, Yusuke Tsutsumi, Tadashi Nagato, Chihiro Narita, Tomohiro Nawa, Tadayoshi Nonoyama, Masatoshi Hanada, Kotaro Hirakawa, Akiko Makino, Hirotaka Masaki, Ryosuke Matsuki, Shinya Matsushima, Wataru Matsuda, Saori Miyagishima, Masaru Moromizato, Naoya Yanagi, Kota Yamauchi, Yuhei Yamashita, Natsuhiro Yamamoto, Keibun Liu, Yuki Wakabayashi, Shinichi Watanabe, Hiroshi Yonekura, Nobuto Nakanishi, Tetsuya Takahashi, Osamu Nishida,
Abstract Providing standardized, high-quality rehabilitation for critically ill patients is a crucial issue. In 2017, the Japanese Society of Intensive Care Medicine (JSICM) promulgated the “Evidence-Based Expert Consensus for Early Rehabilitation in the Intensive Care Unit” to advocate for the early initiation of rehabilitations in Japanese intensive care settings. Building upon this seminal work, JSICM has recently conducted a rigorous systematic review utilizing the Grading of Recommendations, ...
Tópico(s): Hip and Femur Fractures
2023 - BioMed Central | Journal of Intensive Care
Asuka Kawano, Hideaki Miyachi, Masayuki Ota, Jun-ichiro Ikeda, Takashi Inozume,
Tópico(s): Vascular Malformations and Hemangiomas
2024 - John Libbey Eurotext | European Journal of Dermatology
H. Tsukuda, Asuka Tsuya, Hasegawa Yukihiro, Takayo Ota, M. Fukuoka,
Tópico(s): Medical Imaging and Pathology Studies
2022 - Oxford University Press | QJM
M. Veitenhansl, K. Stegner, F. X. Hierl, C. Dieterle, Hermann Feldmeier, B Gutt, R. Landgraf, Adam Garrow, Loretta Vileikyte, Andrew H. Findlow, Carrie Waterman, A. J. M. Boulton, Kshitij Shankhdhar, LK Shankhdhar, U Shankhdhar, Nina L. Petrova, A FOSTER, Michael Edmonds, Roberto Ferraresi, C. Caravaggi, R. De Giglio, Paola Cavaiani, Ileana Pogliaghi, Elena Sommariva, Irwin Katz, A W Harlan, Bresta Miranda-Palma, Luz Prieto-Sanchez, David G. Armstrong, John H. Bowker, Mark S. Mizel, Simona Cernea, Jay Wohlgelernter, Miriam Kidron, Pramila Modi, Itamar Raz, Ehud Arbit, Leszek Nosek, Christoph Kapitza, Philip R. Beckett, R. Gelfand, Marcel Goldberg, Tim Heise, Marcia A. Testa, Ralph R. Turner, J. F. Hayes, Richard E. Scranton, D. C. Simonson, Yang Yuan, Y.-J. Hsu, Ortwin Naujok, Flavio Francini, Anne Jörns, Markus Tiedge, Sigurd Lenzen, Yasser H.A. Abdel‐Wahab, Lamin Marenah, D. F. Orr, Cassidy Lia Shaw, Peter R. Flatt, Kamal Chokkalingam, P. I. Mansell, Per Axel Clausen, Pia Ekbom, Peter Damm, Ulla Feldt‐Rasmussen, Britt A. Nielsen, Elisabeth R. Mathiesen, Bo Feldt‐Rasmussen, Shivani Dewan, Nicole Da Silva, P. Mc Ternan, K Leong, John Wilding, Natalia Asatiani, Ramaz Kurashvili, M. Dundua, Elena Shelestova, K I Pagava, M. Ramazashvili, Moshe Hod, Sergey Smirnov, J.L. Petersen, T. Justesen, Lene Ringholm, Christian Müller, K. Højlund, Andreas J. Wensaas, Elizabeth Kase, Vigdis Aas, A. C. Rustan, G. Hege Thoresen, Klaus Levin, Henning Beck‐Nielsen, Michael Gaster, Suyeol Im, Sung‐Yoon Kang, Saintpee Kim, Yong‐Ho Ahn, A. S. Lihn, Dieter Schmoll, Tim C. Werner, A. Kienitz, M. Renée Umstattd Meyer, A. Barthel, F. Ailett, Calum Sutherland, Rodolfo Álvarez-Sala Walther, Rolf Grempler, Shlomo Sasson, Rudolf H. Reich, Tobias Tenenbaum, Ellen Alpert, Giovanni Anfossi, Isabella Russo, M. Traversa, Paola Massucco, Luigi Mattiello, Gabriella Doronzo, Mariella Trovati, Sean Lally, Chenxin Tan, D. Owens, G. H. Tomkin, Isabelle Porchay, Franck Péan, N. Bellili, D. Betoulle, Beverley Balkau, J. Tichet, M. Marre, F. Fumeron, G. Chatellier, F. Alhenc-Gelas, Gregory A. Nichols, Judith Brown, Risa P. Hayes, Lyndsey J. Bowman, Heinz Drexel, C.H. Saely, Thomas Marte, Werner Benzer, P. Langer, Guenter Hoefle, Willi Moll, Stefan Aczél, Efstratios Karagiannis, G Lübben, Robin Urquhart, G. Edwards, S. Bruce, H. S. C. Howlett, N. Cugnardey, K. C. Turner, J.-S. Park, F. T. Fiedorek, Angelo Avogaro, A. Gallo, Piergiacomo Calzavara‐Pinton, R Rizzuto, Emily Murphy, G. Ceolotto, I D Caterson, B Guy-Grand, Jai Hill, M. Barone, Antonella Aiello, G. Allochis, Vito Borzı̀, Francesca Cannata, S Caronna, Antonio d'Avanzo, R. Elli, Gloria Formoso, Augusto F. Paroli, R. Scardapane, Pierluigi Sorichetti, Patrizio Tatti, Giorgio Luciano Viviani, Fausto Santeusanio, Daniela Manzella, Roberto Grella, Angela Marie Abbatecola, Giuseppe Paolisso, L. G. Søndergaard, T.B.M. Monster, Søren Paaske Johnsen, Maria Olsen, J. K. McLaughlin, Henrik Toft Sørensen, H. H. Lervang, Jørgen Rungby, V. Lyssenko, Jonas Fredriksson, Peter Almgren, Dragi Anevski, Marju Orho‐Melander, Moa Sjögren, Jaakko Tuomilehto, Leif Groop, Riphed Jaziri, R. Aubert, J. Tuomilehto, Geng Dong Hu, Pekka Jousilahti, Markku Peltonen, Jaana Lindström, Ageliki Laina, Maria Alevizaki, George Philippou, A. Souvatzoglou, E. Anastasiou, Samie Reyes de Alba, Bradley S. Metcalf, L D Voss, Alison Jeffery, Terence J. Wilkin, C. Glüimer, Stephen Colagiuri, Dorte Vistisen, K. Borch‐Johnsen, Aveni Haynes, Carol Bower, Max Bulsara, T.W. Jones, Elizabeth A. Davis, Henrik B. Mortensen, Philip Hougaard, Reinhard W. Holl, Peter Swift, Flemming Pociot, Mikael Knip, Leif Hansen, Agnieszka Szadkowska, Iwona Pietrzak, Agnieszka Zmysłowska, Krystyna Wyka, Jerzy Bodalski, Reinhard W. Holl, Robin Swift, Rikke Frøhlich Hougaard, EM Gerstl, I Engelsberger, Wolfgang Rabl, Joachim Rosenbauer, H Gröbe, Sabine E. Hofer, U. Krause, D. Dabelea, T. Morgan, D. J. Pettitt, Lawrence M. Dolan, Elizabeth J. Mayer‐Davis, C. Pihoker, Teresa A. Hillier, G. Imperatore, Andrea Ruggiero, R. E. Hamman, Andreas Stylianou, N. Tentolouris, Δέσποινα Περρέα, Alexandros D. Tselepis, E. Lourida, E. Kitsou, Nikolaos Katsilambros, Monica Vedovato, A. R. Dodesini, Gianluca Lepore, Antonio Tiengo, R. Trevisan, Giuseppe Penno, Roberto Miccoli, Laura Pucci, Daniela Lucchesi, S. Bandinelli, Carmen Fotino, S. Triscornia, E. Baldassari, S. Del Prato, Gianpaolo Reboldi, Egidio Santeusanio, J.H. Fuller, Robyn G. Langham, Renae M. Gow, Y. Zhang, Dominique Kelly, Per K. Christensen, H.-H. Parving, R Gilbert, Alexander Chibalin, Zhao Zhong, О. С. Котова, A. Davidescu, Ira Ehren, K. Ekberg, J. Wahren,
Springer Science+Business Media