A. K., T. R. T., D. M. H., C. W. D., Louis J. Bristow, R. M. L., William A. Courtenay,
... Rally to the Rescue of Quary, While …, Sen Ator Mcalhaney Dead Dorchester County and St. George Lose ... Sacrifice, Senator Gray's Successor, The Late En Ator Maorrill Impressive Funeral Services at Montpeler, the Capital ...
1899 - Gale Group | SAS Part 1
Giacomo Cusumano, Jacopo Romagnoli, Giovanna Liuzzo, L. Petracca Ciavarella, Anna Severino, Giorgia Copponi, M. Manchi, Simona Giubilato, Gian Franco Zannoni, Egidio Stigliano, M.E. Caristo, Filippo Crea, Franco Citterio,
... of N-acetylcysteine (NAC) and high-dose atorvastatin (ATOR) in reducing oxidative stress in a rat kidney ... of pre-ischemic administration of NAC and/or ATOR were evaluated within 4 groups: a) control (no NAC, no ATOR); b) NAC (intraperitoneal NAC administration); c) ATOR (oral ATOR administration); and d) NAC+ATOR (both drugs). Oxidative stress was assessed by measuring ... was evaluated by means of renal histology.NAC, ATOR, and NAC+ATOR in rats showed lower MPO (P < .05) and ... control; SOD activity was lower in NAC versus ATOR (P < .05). No difference among groups was found ...
Tópico(s): Cardiac Ischemia and Reperfusion
2015 - Elsevier BV | Transplantation Proceedings
WALTER FABER. House of Commons, Oct. 3., A. F. LONDON. EDGAR ALBAN. HUBERT M. SOUTHWARK., CROSS., C. A. CRIPPS., JAMES W. LOWTHER. J.WOLFE BARRY., LEIGH, President., ETHEL A. C. HARRIS., Manchester, Oct 31. C. P. SCOTT., MAJOR GREENWOOD. 34, Copthall-avenue, London Wall, E.C., Oct. 30., CHARLES H. STILEMAN, Bishop in Persia. Sunnyside House, Wimbledon, S.W., Oct. 30., JOHN B. LOCK. Gonville and Caius College, Cambridge., JESSE COLLINGS. House of Commons, Oct. 29., MONTAGU OF BEAULIEU. The office of The Car, 62, Pall mall, S.W., Oct. 31., VICTOR HORSLEY., E. A. GURNEY SMITH. Romanhurst, Bromley, Kent, Oct. 28., A DEBENTURE-HOLDER., October 26. INVESTOR.,
... Court and Social: Court Circular. Obituaries: Obituary, Sen Ator Adam Bell., Mr. W.J. Seton.. Sport: Boxing. ...
1912 - Gale Group | TDA
Jieru Cai, Xiaofang Yu, Bingying Zhang, Hui Zhang, Yi Fang, Shaopeng Liu, Tongqiang Liu, Xiaoqiang Ding,
To investigate the impacts of combinatorial atorvastatin (Ator) perioperative administration and mesenchymal stem cell (MSC) implantation on therapeutic effects in the rat experimental acute kidney injury.The model of renal ischemia- ... artery of the animals pretreated with or without Ator.The combined treatment with Ator and MSCs (Ator+MSCs) markedly reduced the elevated levels of serum ... cell apoptosis and promotion of proliferation in the Ator+MSCs group compared with the other groups. Consistent with the improvement in renal function and morphology, Ator pretreatment significantly ameliorated oxidative stress, inhibited inflammation response, ...
Tópico(s): Metabolism and Genetic Disorders
2014 - Karger Publishers | American Journal of Nephrology
Mr. Chamberlain, F. W. Young, W. J., Cyclophil, W. R. Con, Mrs Jack …, Will Scarlett, W. T. Pierce, Hutchinson, Richard King, H. E. G., Jas R. Williamson, H. K., Robinson, Sir B. W. Richardson, E. R.,
... from Course and Stable Lingfield Meeting Vaticinator: Vaticin Ator's Finals (From our Own Correspondents): Special Notes ...
1896 - Gale Group | Sunday Times HA GDA
Suxia Guo, Ruxing Wang, Zhenyu Yang, Ku-lin Li, Qiang Wang,
... receive placebo (placebo group, n=54) or atorvastatin (ATOR) at a single daily dose of 10 mg (ATOR 10 mg group, n=47), 20 mg (ATOR 20 mg group, n=45), 40 mg (ATOR 40 mg group, n=43) or 80 mg (ATOR 80 mg group, n=39). Endpoints, including serum ... of follow-up, the LDL levels in the ATOR groups were below those at their respective baselines (P<0.01). HDL levels in the ATOR 80 mg group following treatment were significantly higher ... significantly higher compared with those in the placebo, ATOR 10, 20 and 40 mg groups (P<0. ...
Tópico(s): Cardiac Imaging and Diagnostics
2012 - Spandidos Publishing | Experimental and Therapeutic Medicine
Malcolm Brown, Frances Gibb, Legal Affairs Correspondent, A. M. Coupland, Holly Hill, John A. C. Humphries Deputy Chairman, Simon Barnes, Michael Clark and Carol Leonard, Malcolm Longair, Geraldine Norman, Sale Room Correspondent, Lyudomir Ivanov, Cliff Feltham, Philip Howard, Sally Brompton, Gavin Bell Arts Correspondent, Ian Murray, David Hart, Michael Binyon, Richard Streeton, Richard Eaton, Gerald Thornton, Stuart Jones Football Correspondent, Caroline Moorehead, Peter Davenport, Defence Correspondent, Geoffrey Smith, Howard Foster, Stephen Taylor, Stuart Jones, Ahmed Fazl, Alex Jacob, Teresa Poole, Business Correspondent, Judith Huntley Commercial Property Correspondent, Pearce Wright Science Editor, Lawrence Lever, Alan Hamilton, Martin Cropper, Jenny MacArthur, Michael Hamlyn, Diana Geddes, Richard Evans, Political Correspondent, John Percival, Richard Thomson, Banking Correspondent, Rex Bellamy, Tennis Correspondent, John Hennessy, Jeffrey Hamm, Secretary, Mary Dines, Gavin Bell, Mr Jeffrey Hamm, Sydney Friskin, David Smith, Economics Correspondent, Robin Oakley Political Editor, Philip Webster, Chief Political Correspondent, (Michael Phillips), Nicolas Soames, Josephine Fairley, J. W. Arriens, Tony Samstag, David Miller, Chief Sports Correspondent, David Watts, Nicholas Wood Political Reporter, Alison Eadie, Alexandra Jackson, Mark Dowd, Education Reporter, Richard Evans, Sheila Gunn, Political Staff, Jill Sherman, Craig Seton, Richard Owen, PHS, Barry Pickthall, Irving Wardle, Roger Boyes, Bryan Appleyard, P. G. Walsh, Keith MacKlin, Edward Townsend Industrial Correspondent, David Hands Rugby Correspondent, Devlin, Kenneth Fleet, Hugh Clayton, John Goodbody, David Young, Anne Campbell Dixon, Geraldine Norman, Judith Huntley, John Wilcockson, Clive White, Edward McMillan-SCOTT, Michael Hornsby, Dominic Milroy, Michael Dynes, David Sinclair, Stephen Pettitt, Neil Harding, Michael Horsnell, Frances Gibb Legal Affairs Correspondent, Nicholas Shakespeare, Bailey Morris, Richard Morrison, Lee Rodwell, Harvey Elliott Air Correspondent, A. V. Antonovics, Richard Ford, Colin McQuillan, Rodney Lord Economics Editor, Peter Evans, Home Affairs Correspondent, Ivor Davis,
... Advertising Items 9Am - 3pm Multiple Classified Advertising Items ATOR Ask Alfred Marks Local Authorities Conditions of Service ...
1986 - Gale Group | TDA
Tingting Cheng, Changkun Li, Linyan Shen, Shujie Wang, Xuelin Li, Chenyang Fu, Tingting Li, Bei Liu, Yanyun Gu, Weiqing Wang, Bo Feng,
... we aimed to investigate whether effects of atorvastatin (Ator) on gut microbiome and metabolic inflammation could be ... with high-fat diet (HFD) or HFD with Ator (HFD+Ator) for 16 weeks. 16S rRNA sequencing of stool ... the intestinal alterations that could be induced by Ator. A human colon carcinoma cell line (Caco2) was ... experiments on barrier function. Compared to HFD, HFD+Ator induced more weight gain, impaired glucose tolerance, and ... binding-protein (LBP) level was elevated in HFD+Ator mice, so as to transcriptionally activate the intestinal ...
Tópico(s): Oral microbiology and periodontitis research
2022 - Frontiers Media | Frontiers in Microbiology
Philip Webster and Sheila Gunn, Teresa Poole, Miles Kington, Victoria Glendinning, Mark Dowd Education Reporter, Ian McLauchalan, Peter Davenport Defence Correspondent, Keith Dalton, Peter Marson, Barbara E. Clayton (President), Michael Clark and Carol Leonard, Geraldine Norman, Sale Room Correspondent, Sheila Gunn and John Winder, Valerie Murray, Ian McLauchlan, John Bell, City Editor, Ian Murray, Michael Binyon, Richard Streeton, Stuart Jones Football Correspondent, Mario Modiano, Stewart Tendler, Crime Correspondent, Geoffrey Smith, Gerald Davies, Howard Foster, Mitchell Platts, Stephen Taylor, Mohsin Ali, Michael Evans, Whitehall Correspondent, Pearce Wright Science Editor, Peter Ackroyd, Alan Hamilton, Martin Cropper, Rupert D. H. Bursell, Jenny MacArthur, Michael Hamlyn, David Hands, John Percival, Lawrance Freedman, Geoffrey Matthews, John Hennessy, Martin Fletcher Political Reporter, F. E. Jones, Harvey Elliott, Air Correspondent, N. P. Goozee (Manager), Ronald Fletcher, Paul Vallely, David Cross, Neil Kelly, Sydney Friskin, W. A. Wilson, David Smith, Economics Correspondent, Mary Bogan, (Michael Phillips), David Miller, Chief Sports Correspondent, Nicholas Wood Political Reporter, Trudi McIntosh, Robin Oakley, Political Editor, Alison Eadie, Nicholas Beeston, Judith Huntley, Commercial Property Correspondent, D. M. D. Evans (President), Geraldine Norman Sale Room Correspondent, David Owen, Paul Vittles, Conrad Voss Bark, I. Benveniste, Craig Seton, Jill Sherman, Richard Owen, PHS, Barry Pickthall, Keith Wheatley, Irving Wardle, Marcel Berlins, Roger Boyes, Peter Lawson (General Secretary), Ronald Butt, Bryan Appleyard, Derek Harris, Industrial Editor, Keith MacKlin, David Hands Rugby Correspondent, Kenneth Fleet, Christopher Thomas, Professor L. Kessel, Ian Smith, Anne Campbell Dixon, Christopher Walker, Peter Evans, Carol Ferguson, Judith Huntley, Carol Handley, Clive White, Neil Harris, Michael Hornsby, Robert Grieves, David Sinclair, Stephen Pettitt, Malcolm Macnaughton (President), Michael Horsnell, Frances Gibb Legal Affairs Correspondent, Christopher Follett, Nicholas Shakespeare, M. N. Duffy, President, Bailey Morris, Nicholas Wood, Political Reporter, Robert Fisk, Rodney Lord, Economics Editor, Corinne Julius, Richard Morrison, Derek Harris Industrial Editor, John Campbell, Gillian Greenwood, Pearce Wright, Science Editor, Ann Hills, Colin McQuillan, Peter Evans, Home Affairs Correspondent, Barry Shurlock, Richard Wigg,
... Assistant Cooks Chalet Girls Multiple Classified Advertising Items Ator Rentals Multiple Classified Advertising Items Albert Studies SW11 ...
1986 - Gale Group | TDA
Zhong-Yan Zhou, Wai-Rong Zhao, Ying Xiao, Jing Zhang, Jingyi Tang, Simon Ming‐Yuen Lee,
... of the protective effect of STS against atorvastatin (Ator)-induced cerebral hemorrhage in zebrafish using RNA-seq technology. RNA-seq revealed 207 DEGs between the Ator-treated group and control group; the expression levels of 53 DEGs between the Ator-treated group and control group were reversed between the STS + Ator-treated group and Ator-treated group. GO enrichment analysis indicated that these ... 12 hub genes, and we further verified that Ator elevated the mRNA expression levels of hemoglobin (hbae1. ...
Tópico(s): Autophagy in Disease and Therapy
2020 - Frontiers Media | Frontiers in Pharmacology
Anne Månsson Kvarnhammar, Niina Veitonmäki, Karin Hägerbrand, Anna Dahlman, Karin Enell Smith, Sara Fritzell, Laura von Schantz, Mia Thagesson, Doreen Werchau, Kristine Smedenfors, Maria H. Johansson, Anna Rosén, Ida Åberg, Magnus Winnerstam, Eva Nyblom, Karin Barchan, Christina Furebring, Per Norlén, Peter Ellmark,
... targeting therapies with improved benefit-risk profile. Methods ATOR-1015 is a human CTLA-4 x OX40 ... markers and tumor localization using flow cytometry. Results ATOR-1015 induces T-cell activation and Treg depletion in vitro. Treatment with ATOR-1015 reduces tumor growth and improves survival in ... pancreas cancer models. It is further demonstrated that ATOR-1015 induces tumor-specific and long-term immunological ... enhances the response to PD-1 inhibition. Moreover, ATOR-1015 localizes to the tumor area where it ...
Tópico(s): T-cell and B-cell Immunology
2019 - BMJ | Journal for ImmunoTherapy of Cancer
Tatsuma Okazaki, Amy Ni, Oluwasheyi A. Ayeni, Peter Bałuk, Li-Chin Yao, Doerte Vossmeyer, Gunther Zischinsky, Grit Zahn, Jochen Knolle, Claudia Christner, Donald M. McDonald,
... central role in lymphangiogenesis.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ... regions between the rings.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ... lymphatics in inflammatory conditions.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ... lymphatics in the airways.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ... CT7) as described previously.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ... ventricle into the aorta.31Baluk P Tammela T Ator E Lyubynska N Achen MG Hicklin DJ Jeltsch ...
Tópico(s): Angiogenesis and VEGF in Cancer
2009 - Elsevier BV | American Journal Of Pathology
Haiming Dang, Bangrong Song, Ran Dong, Hongjia Zhang,
... endothelial cells (HUVECs), and the effects of atorvastatin (Ator) on induced HUVECs in vitro. The cytotoxicity of Ang II and Ator was determined by the MTT assay. A series ... oxide synthase and the angiogenic function of HUVECs. Ator returned these cellular responses to a normal level. ... demonstrated by a decreased mitochondrial membrane potential, while Ator attenuated this Ang II‑induced damage. The observed ... functions triggered endothelial senescence, which was delayed by Ator. Ator also suppressed Ang II‑induced angiogenesis damage. ...
Tópico(s): Lipoproteins and Cardiovascular Health
2018 - Spandidos Publishing | Experimental and Therapeutic Medicine
Miao Chen, Hongwei Li, Guoxing Wang, Xuhua Shen, Shu-mei Zhao, Wen Su,
... We aimed to investigate the effects of atorvastatin (Ator) on the AGEs-induced cardiac fibrosis both in ... were randomly divided into four groups: Control, AGEs, Ator or AGEs + Ator. The cardiac function was evaluated with the echocardiography ... cardiac fibroblasts were treated with PD98059 (ERK inhibitor), Ator or Ator + GW9662 (PPAR-γ antagonist), and then were stimulated ... with the control group, in vivo treatment with Ator significantly retarded the AGEs-induced diastolic function and ... and RAGE over expression induced by AGEs. Consistently, Ator prominently downregulated RAGE and α-SMA, while inhibited ...
Tópico(s): Diabetes, Cardiovascular Risks, and Lipoproteins
2015 - Elsevier BV | Metabolism
Lei Song, Yue-Jin Yang, Qiu-Ting Dong, Hai-Yan Qian, R Gao, Shu-bin Qiao, Rui Shen, Zuo-Xiang He, Minjie Lu, Shihua Zhao, Yong-Jian Geng, Bernard J. Gersh,
... unclear. This study aims at assessing whether atorvastatin (Ator) facilitates the effects of MSCs through activation of ... groups (n = 7/group): Sham operation; AMI control; Ator only; MSC only, Ator+MSCs and Ator+MSCs+NG-nitrol-L-arginine (L-NNA), an ... weeks after transplantation, compared with the control group, Ator+MSCs animals exhibited decreased defect areas of both " ... MSCs or MSC-derived cells were increased in Ator+MSCs animals. In Ator or MSCs alone group, perfusion, metabolism, inflammation, fibrosis ...
Tópico(s): Cardiac Ischemia and Reperfusion
2013 - Public Library of Science | PLoS ONE
Mohamed A. El‐Moselhy, Azza A. K. El‐Sheikh,
... be prevented by the cholesterol-lowering statin, atorvastatin (Ator), Ator (10 mg/kg) was administered orally for 10 ... at day 5 of experiment, with or without Ator. DOX caused deterioration in hepato-renal function, as ... in normal renal and hepatic histology. Pretreatment with Ator preserved kidney and liver function and histology. DOX ... in malondialdehyde (MDA) compared to control. Combined DOX/Ator significantly reversed these values compared to DOX in ... tissue nitric oxide compared to control. Concomitant DOX/Ator treatment decreased NO in kidney and liver. Furthermore, ...
Tópico(s): Cancer, Lipids, and Metabolism
2013 - Elsevier BV | Biomedicine & Pharmacotherapy
Jing Xia, Siyue He, Qianlong Dai, Huijie Jia, Yuchen Ge, Min Zhou, Xiaobo Wang,
... treatment. According to the current study, Atorvastatin calcium (Ator) alleviated cellular senescence in human intestinal epithelial cells ( ... 1β, IL-6, TNF-α), while Atorvastatin calcium (Ator) reversed the increase in these indicators. In the ... drug-induced inflammation, with the therapeutic effects of Ator. In addition, Ator increased the sensitivity of 5-Fu to chemotherapy ... Combination therapy significantly reduced HCT116 cell viability. Furthermore, Ator and 5-Fu present a cooperative effect on ... In conclusion, our study demonstrates the value of Ator for treating intestinal damage. Moreover, Ator combined with ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2023 - Elsevier BV | International Immunopharmacology
Hadi Nedaei, Nasrollah Rezaei‐Ghaleh, Karin Giller, Stefan Becker, Leila Karami, Ali Akbar Moosavi‐Movahedi, Christian Griesinger, Ali Akbar Saboury,
... models, it has previously been shown that atorvastatin (Ator), a cholesterol-lowering drug, has some reducing effect ... Here, we explore a potential direct effect of Ator on Aβ42 aggregation. Using NMR-based monomer consumption ... CD spectroscopy, we observed a promoting effect of Ator in its original form (Ator-calcium) on Aβ42 aggregation, as expected because of ... inhibited significantly when the concentration of calcium-free Ator exceeded that of Aβ by at least a ... transfer difference NMR data suggest that calcium-free Ator exerts its effect through interaction with the 16KLVF19 ...
Tópico(s): Protein Structure and Dynamics
2022 - Elsevier BV | Journal of Biological Chemistry
Ali Osman, Nashwa El‐Gazzar, Taghreed N. Almanaa, Abdalla El‐Hadary, Mahmoud Sitohy,
... anti-obesity and Anti-dyslipidemia agent replacing atorvastatin (ATOR) and other drugs with proven or suspected health ... 1) for nine weeks, as compared to atorvastatin (ATOR; 10 mg kg−1). The postbiotic could correct ... antioxidant enzymes in HFD rats more effectively than ATOR. The two levels of the postbiotic (100 and ... level, compared to only 25% and 35% in ATOR’s case, respectively. Both ATOR and the postbiotic (200 mg kg−1) equally ... HFD-induced body weight increases more effectively than ATOR without affecting liver and kidney functions or liver ...
Tópico(s): Computational Drug Discovery Methods
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Zhong-Yan Zhou, Bin Huang, Shang Li, Xiao-Hui Huang, Jingyi Tang, Yiu Wa Kwan, Maggie Pui Man Hoi, Simon Ming‐Yuen Lee,
... clinical studies of ischemic stroke, by using atorvastatin (Ator) induced ICH zebrafish embryos and human umbilical vein ... the occurrence and area of hemorrhage induced by Ator in zebrafish and restored impairment in motor function. We further demonstrated that Ator-induced disruption in VE-cadherin (VEC)-containing cell- ... and RhoA/ROCK-mediated cellular contraction. STS inhibited Ator-induced Src activation and subsequent VEC internalization and ... and increasing barrier functions. STS also inhibited the Ator-induced RhoA/ROCK-mediated cellular contraction by regulating ...
Tópico(s): Kruppel-like factors research
2018 - Elsevier BV | Toxicology and Applied Pharmacology
María de La Paz Scribano, María del Carmen Báez, Becerra Florencia, Mariana Tarán, Signorini Franco, Ariel Balceda, Mónica Moya,
... stress, and atherogenesis was established. Effect of atorvastatin (Ator) was assessed. Wistar male (6 months) rats were studied: Ctr, control, without HF induction; Ctr-Ator, without HF treated with atorvastatin; AI, atherogenesis induced, and AI-Ator, atherogenesis induced and treated with atorvastatin. Atherogenesis was ... it decreased after administration of atorvastatin in AI-Ator ( P < 0 . 001 ). NO diminished in AI relative to Ctr and increased in AI-Ator ( P < 0 . 001 ). SOD showed an increase in AI and AI-Ator compared to Ctr ( P < 0 . 001 ). EM revealed ...
Tópico(s): Lipoproteins and Cardiovascular Health
2014 - Hindawi Publishing Corporation | Advances in Medicine
Anping Cai, Ruofeng Qiu, Liwen Li, Dongdan Zheng, Yugang Dong, Danqing Yu, Yuli Huang, Shaoqi Rao, Yingling Zhou, Weiyi Mai,
... factor responsible for ASCs migration and survival. Atorvastatin (Ator) is capable of up-regulating SDF-1α. Therefore, ... subsequently divided into different groups: group blank control, Ator, Ator plus L-NAME (A+L-NAME) and Ator plus AMD3100 (A+AMD3100).When migration analysis completed, ... migration in vitro was significantly improved in group Ator, which was dependent on SDF-1α/CXCR-4 ... CXCR-4 axis. Higher vessel density in group Ator might be another mechanism responsible for migration improvement. Concomitantly, apoptosis was significantly reduced in group Ator, whereas no significant difference of differentiation was found. ...
Tópico(s): Cardiac Fibrosis and Remodeling
2013 - Public Library of Science | PLoS ONE
Amene Naseri, M. Reza Hormozi‐Nezhad, Saeed Shahrokhian, Elham Asadian,
... we report on the electrochemical determination of atorvastatin (ATOR) by using silver nanowires/gold-modified glassy carbon ... of Ag nanowires. The electrochemical response characteristics of ATOR are investigated by means of cyclic and differential ... volume on the differential pulse voltammetric responses of ATOR is evaluated. The results revealed that under the ... a remarkable enhancement in the peak current of ATOR associated with a noticeable decrease in its peak ... ability of the modified electrode to successfully determine ATOR in pharmaceutical and human plasma samples turned it ...
Tópico(s): Conducting polymers and applications
2020 - Elsevier BV | Journal of Electroanalytical Chemistry
Jeffrey Yachnin, Gustav Ullenhag, Ana Paula Carneiro, Dorte Nielsen, Kristoffer Rohrberg, Anne Månsson Kvarnhammar, Lena Schultz, Erika Bågeman, Camilla Wennersten, Charlotte Russell,
3061 Background: ATOR-1015 is a human CTLA-4 x OX40 targeting IgG1 bispecific antibody developed to be a next generation ... with advanced solid malignancies. Safety and tolerability of ATOR-1015 are assessed by adverse events (AEs), vital ... design (NCT03782467). Intra-patient dose escalation is allowed. ATOR-1015 is administered intravenously every other week as ... February 2020, 15 patients have been exposed to ATOR-1015. The median age of the patients is ... up to 200 mg. Conclusions: The dosing of ATOR-1015 has been safe and well-tolerated up ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2020 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Linyan Shen, Yanyun Gu, Yixuan Qiu, Tingting Cheng, Aifang Nie, Canqi Cui, Chenyang Fu, Tingting Li, Xuelin Li, Lihong Fu, Yanqiu Wang, Qicheng Ni, Qidi Wang, Weiqing Wang, Bo Feng,
... underlying mechanism has not been determined. In atorvastatin (ator)-treated high-fat diet–fed mice, we found ... Transcriptome profiling of primary pancreatic islets showed that ator inhibited the expression of pancreatic transcription factor, mechanistic ... A (MafA) expression, and β-cell function after ator, lovastatin, rosuvastatin, and fluvastatin treatment; this effect was ... the sGP in pancreatic islets most affected by ator treatment, was found to positively regulate mTOR signaling ... cell function. Rab5a knockdown mimicked the effect of ator treatment on β-cells. Thus, ator impairs β- ...
Tópico(s): Protein Kinase Regulation and GTPase Signaling
2019 - American Diabetes Association | Diabetes
Xiao‐Min Ren, Guang‐Feng Zuo, Wen Wu, Jie Luo, Peng Ye, Shao‐Liang Chen, Hu Zy,
Recent studies reported that atorvastatin (ATOR) alleviated progression of experimental diabetic cardiomyopathy (DCM), possibly by protecting against apoptosis. However, the underlying mechanisms of this protective effect remain ... in the anti-apoptotic and cardioprotective effects of ATOR on cardiomyocytes cultured in high glucose (HG) and ... inhibited and apoptosis attenuated in cells treated with ATOR. These effects occurred through inactivation of GSK-3β ... mice with type 1 diabetes mellitus, treatment with ATOR, at 10 mg-kg−1-d−1, significantly ...
Tópico(s): Signaling Pathways in Disease
2016 - Public Library of Science | PLoS ONE
Chi‐Hung Liu, Tien‐Hsing Chen, Ming‐Shyan Lin, Ming‐Jui Hung, Chang-Ming Chung, Wen‐Jin Cherng, Tsong‐Hai Lee, Yu‐Sheng Lin,
... 20-mg simvastatin (EZ-SIM), 40-mg atorvastatin (ATOR), and 20-mg simvastatin (SIM) groups for further ... SIM group was higher than that of the ATOR (hazard ratio [HR], 2.03; 95% confidence interval [ ... lower in the EZ-SIM compared with the ATOR group (HR, 1.20; 95% CI, 0.85- ... the SIM group (28.2%), followed by the ATOR (16.1%) and EZ-SIM (15.4%) groups. ... of recurrent IS in the EZ-SIM and ATOR groups compared with the SIM group.High-potency ... of recurrent IS in diabetic patients regardless of ATOR or EZ-SIM combination therapy.
Tópico(s): Cardiac Imaging and Diagnostics
2016 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Zhifang Zhao, Wei Cui, Hailin Zhang, Haixia Gao, Xuze Li, Yuanyuan Wang, Haijuan Hu, Bo Li,
... shown that a high loading dose of atorvastatin (Ator) within 24 h before percutaneous coronary intervention (PCI) ... the potential mechanisms regarding this rapid benefit of Ator remain elusive. Our study introduced three different ischaemia/ ... protective effect of a single loading dose of Ator pre-treatment and further to explore the potential ... found that the pre-treatment of high-dose Ator decreased the cardiac injury and maintained the integrity ... The results showed that the pre-treatment of Ator significantly decreased I/R-induced injury, and maintained ...
Tópico(s): Anesthesia and Neurotoxicity Research
2015 - Elsevier BV | European Journal of Pharmacology
Jyothi C. Abbar, Sharanappa T. Nandibewoor,
... oxidation and determination of an antihyperlipoproteinemic drug, atorvastatin (ATOR), at a carbon paste electrode (CPE) in the ... The results indicated that the voltammetric response of ATOR was improved distinctly in the low concentration of ... exhibits noticeable enhancement effect to the determination of ATOR. The dependence of current on pH, concentration and ... optimize the experimental conditions for the determination of ATOR. The anodic peak was characterized and the process ... property as a function of the concentration of ATOR with a detection limit of 4.08 nM ...
Tópico(s): Analytical Chemistry and Sensors
2013 - Elsevier BV | Colloids and Surfaces B Biointerfaces
Ki Hoon Han, Seung‐Woon Rha, Hyun–Jae Kang, Jang‐Whan Bae, Byoung‐Joo Choi, So‐Yeon Choi, Hyeon‐Cheol Gwon, Jang–Ho Bae, Bum‐Kee Hong, Donghoon Choi, Kyoo-Rok Han,
... n = 97) or atorvastatin 10-20 mg/day (ATOR, n = 92). Pitavastatin and atorvastatin equally reduced low- ... of variance). Seven (n = 4 PITA, n = 3 ATOR) and 10 (n = 5 PITA, n = 5 ATOR) patients experienced episodes of ALT >100 IU/L ... treatment with PITA (n = 68, -8.4%) or ATOR (n = 67, -8.9%; P < .05, analysis of ... in 38 subjects (n = 18 PITA, n = 20 ATOR) showed that both statins reduced the severity of ... steatosis at baseline (n = 9 PITA, n = 10 ATOR). Statin treatment of another 38 subjects with spontaneous ...
Tópico(s): Lipoproteins and Cardiovascular Health
2012 - Elsevier BV | Journal of clinical lipidology