Sayuri Ueda, Ryota Ozaki, Atsuki Kaneko, Ryoma Akizuki, Haruko Katsuta, Atsuhiro Miura, Akira Matsuura, Takashi Ushimaru,
Target of rapamycin complex 1 (TORC1) protein kinase responds to various stresses including genotoxic stress. However, its molecular mechanism is poorly understood. Here, we show that DNA damage induces nonselective and selective autophagy in budding yeast. DNA damage caused the attenuation of TORC1 activity, dephosphorylation of Atg13, and autophagy induction. The TORC1-upstream Rag GTPase Gtr1 was not required for TORC1 inactivation and autophagy induction after DNA damage. Furthermore, DNA damage ...
Tópico(s): CRISPR and Genetic Engineering
2019 - Elsevier BV | Cellular Signalling
Dahiana A. Avila Salazar, Peter Bellstedt, Atsuhiro Miura, Yuki Oi, Toshihiro Kasuga, Delia S. Brauer,
Metal ion complexes influence hydrolysis during phosphate glass dissolution.
Tópico(s): Bone Tissue Engineering Materials
2021 - Royal Society of Chemistry | Dalton Transactions
Atsuhiro Fujimori, Shuntaro Miura, Takahiro Kikkawa, Yuji Shibasaki,
ABSTRACT Precise analyses of the molecular arrangement of three‐dimensional crystals, two‐dimensional molecular films, and interfacial particle layers of polyguanamine derivatives with a high refractive index have been performed. The high refractive index of the polyguanamine derivatives is not due to the chemical structure of the molecule, but is based on the packing of molecular chains or the refraction of transmitted light due to the difference in electron density between the crystalline and ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2015 - Wiley | Journal of Polymer Science Part B Polymer Physics
Tetsuo Ando, Megumi Yamamoto, Takashi Tomiyasu, Jun Hashimoto, Tomoyuki Miura, Atsuhiro Nakano, Suminori Akiba,
The present study reports on the mercury concentrations of the vestimentiferan worm, Lamellibrachia satsuma, (Annelida: Pogonophora) found near hydrothermal vents at a depth of 80-100 m in the northern parts of Kagoshima Bay. The vestimentiferan worms had total mercury concentrations of 238 ng/g in the anterior muscle of the body and 164 ng/g in the posterior trophosome. Methylmercury constituted only 7.6% of total mercury detected anteriorly and 16.3% posteriorly. The mean total mercury concentration ...
Tópico(s): Heavy metals in environment
2002 - Elsevier BV | Chemosphere
Hiroshi Kimura, Kazuhito Takeda, Kazuhiko Tsuruya, Hideyuki Mukai, Yoshiharu Muto, Hiroshi Okuda, Masahide Furusho, Toshiharu Ueno, Satsuki Nakashita, Shuhei Miura, Atsuhiro Maeda, Hideki Kondō,
Diastolic heart failure is the most common clinical form of heart failure. Tissue Doppler imaging (TDI) is often used to quantitate left ventricular (LV) diastolic function. The purpose of this study was to identify the determinant(s) of diastolic dysfunction in patients with end-stage renal disease on hemodialysis (HD), using the TDI method.The study subjects were 53 patients with end-stage renal disease and preserved LV systolic function on maintenance HD. LV function was assessed by conventional ...
Tópico(s): Cardiac Imaging and Diagnostics
2010 - Karger Publishers | Nephron Clinical Practice
Takuya Tsuchihashi, Toshihiko Ishimitsu, Katsuyuki Ando, Miho Kusaka, Atsuhiro Ichihara, Katsuyuki Miura, Yuhei Kawano, Takafumi Ishida, Hiroo Kumagai, Atsushi Sakima, Hiroyuki Takase, Hitomi Hayabuchi, Hiroshi Itoh,
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2020 - Springer Nature | Hypertension Research
Gaku Taira, Kenji Endo, Koichi Ito, Katsuji Ichimaru, Atsuhiro Imakiire, Yukio Miura,
The lumbo-sacral region has anatomical lordosis and two-dimensional magnetic resonance imaging (2D-MRI) cannot therefore show spinal roots including the dorsal root ganglions in one picture. This makes it difficult to present the lateral part of spinal root lesions. We have recently described a new three-dimensional magnetic resonance imaging (3D-MRI) method which allows a stereoscopic view of the spinal cord and spinal nerve roots. In the present study, we evaluated three 3D-MRI techniques, rapid ...
Tópico(s): Medical Imaging and Analysis
1998 - Elsevier BV | Journal of Orthopaedic Science
Yuji Shibasaki, Tomohiro Kotaki, Takahiro Bito, Rina Sasahara, Natsuko Idutsu, Atsuhiro Fujimori, Shuntaro Miura, Yusaku Shidara, Naoya Nishimura, Yoshiyuki Oishi,
Polycondensation of various 2-substituted-4,6-dichloro-1,3,5-triazine such as N,N-diphenylamino (DCPT), benzylamino (BnDCT) substituents with α, ω - alkylene diamines including hexamethylene (HMDA), octamethylene (OcDA), decamethylene (DcDA), and dodecamethylene diamine (DdDA) was performed, and the resultant polymers were analyzed. Two-phase polymerization in nitrobenzene/aqueous NaHCO3 at 100 °C resulted in a high molecular weight (MW) polymer (Mn = 12,400) with a small fraction (26.7 wt%) of low MW oligomer, ...
Tópico(s): Dendrimers and Hyperbranched Polymers
2018 - Elsevier BV | Polymer
Akiko Suga, Kazutoshi Yoshitake, Naoko Minematsu, Kazushige Tsunoda, Kaoru Fujinami, Yozo Miyake, Kazuki Kuniyoshi, Takaaki Hayashi, Kei Mizobuchi, Shinji Ueno, Hiroko Terasaki, Taro Kominami, Nobuhisa Nao‐i, Go Mawatari, Atsushi Mizota, Kei Shinoda, Mineo Kondo, Kumiko Kato, Tetsuju Sekiryu, Makoto Nakamura, Sentaro Kusuhara, Hiroyuki Yamamoto, Shuji Yamamoto, Kiyofumi Mochizuki, Hiroyuki Kondo, Itsuka Matsushita, Shuhei Kameya, Takeo Fukuchi, Tetsuhisa Hatase, Masayuki Horiguchi, Yoshiaki Shimada, Atsuhiro Tanikawa, Shuichi Yamamoto, Gen Miura, Nana Ito, Akira Murakami, Takuro Fujimaki, Yoshihiro Hotta, Koji Tanaka, Takeshi Iwata,
Inherited retinal diseases (IRDs) comprise a phenotypically and genetically heterogeneous group of ocular disorders that cause visual loss via progressive retinal degeneration. Here, we report the genetic characterization of 1210 IRD pedigrees enrolled through the Japan Eye Genetic Consortium and analyzed by whole exome sequencing. The most common phenotype was retinitis pigmentosa (RP, 43%), followed by macular dystrophy/cone- or cone-rod dystrophy (MD/CORD, 13%). In total, 67 causal genes were identified ...
Tópico(s): RNA regulation and disease
2022 - Wiley | Human Mutation
Kentaro Nakai, Kazuhito Takeda, Hiroshi Kimura, Shuhei Miura, Atsuhiro Maeda,
We report the case of a 69-year-old woman with seizures and acute renal failure with hyperkalemia. She presented with bladder turgescence and hydronephrosis on admission and was diagnosed as obstructive acute renal failure. Urethral catheterization was performed after a single-session hemodialysis. It resulted in immediate improvement of renal function and consciousness, and subsequent disappearance of seizures. Improvement of serum creatinine level to 0.7 from 10.6 mg/dL was associated with a fall ...
Tópico(s): Acute Kidney Injury Research
2009 - Elsevier BV | The American Journal of Emergency Medicine
Midori Yatabe, Toshiyuki Iwahori, Ami Watanabe, Kozue Takano, Hironobu Sanada, Tsuyoshi Watanabe, Atsuhiro Ichihara, Robin A. Felder, Katsuyuki Miura, Hirotsugu Ueshima, Junko Kimura, Junichi Yatabe,
The Na/K ratio is considered to be a useful index, the monitoring of which allows an effective Na reduction and K increase, because practical methods (self-monitoring devices and reliable individual estimates from spot urine) are available for assessing these levels in individuals. An intervention trial for lowering the Na/K ratio has demonstrated that a reduction of the Na/K ratio mainly involved Na reduction, with only a small change in K. The present study aimed to clarify the relationship between ...
Tópico(s): Thermoregulation and physiological responses
2017 - Multidisciplinary Digital Publishing Institute | Nutrients
Masayo Sunaga, Keiko Kondo, Toshiko Adachi, Yoshiko Miura, Atsuhiro Kinoshita,
Dental and dental hygiene students must acquire the skill of measuring periodontal pockets and learn to identify the bottom of a pocket, especially of deep periodontal pockets. A new dental model that would enable students to practice measuring deep periodontal pockets was developed at the Tokyo Medical and Dental University. The purpose of this study was to evaluate the feasibility and effectiveness of this model. Twenty dental hygiene students in their third year at the school and twenty–four ...
Tópico(s): Dental Research and COVID-19
2013 - Wiley | Journal of Dental Education
Atsuhiro Miura, Akiko Obata, Toshihiro Kasuga,
To facilitate the efficient use of phosphate-based glasses in various biomedical applications, it is essential to understand the effects of ion-releasing in the living body. In this work, the ion-releasing behavior of silicophosphate glass, designed as a supply source of silicate and phosphate ions that are effective for bone formation, was investigated. Two types of P2O5-SiO2-CaO-Na2O glasses containing 45–50 mol% of P2O5 with both four- and six-fold coordinated silicon structures were prepared. ...
Tópico(s): Luminescence Properties of Advanced Materials
2022 - | Phosphorus Research Bulletin
Hiroshi Kimurâ, Kazuhito Takeda, Yoshiharu Muto, Hideyuki Mukai, Masahide Furusho, Satsuki Nakashita, Shuhei Miura, Atsuhiro Maeda, Kazuhiko Tsuruya,
A 79-year-old man with chronic renal failure developed general fatigue and loss of appetite. He was diagnosed with endstage renal disease and was started on hemodialysis (HD). The symptoms improved immediately, but the mental status deteriorated gradually, reaching Glasgow Coma Scale (GCS) 5. Computed tomography showed no significant intracranial lesion, but magnetic resonance images showed symmetric high-intensity changes in the periaqueductal area, suggestive of Wernicke's encephalopathy (WE). He ...
Tópico(s): Homelessness and Social Issues
2011 - Dustri-Verlag | Clinical Nephrology
Kazumasa Funabiki, Hiroyoshi Mase, Yasuteru Saito, Atsuhiro Otsuka, Atsuhiko Hibino, Nagisa Tanaka, Hidetoshi Miura, Yosuke Himori, Tsukasa Yoshida, Yasuhiro Kubota, Masaki Matsui,
Novel near-infrared (NIR)-sensitizing (up to 800 nm) simple asymmetric squaraine dyes (Sq 31 and Sq 33) carrying indoline moieties that did not require the introduction of any linker groups were developed. DSSCs fabricated with Sq 33 exhibited remarkable characteristics in the long-wavelength visible and NIR region (up to 800 nm), such as a conversion efficiency of 3.75% (AM 1.5G) with an incident photon-to-current conversion efficiency of 63% (650 nm), a short-circuit photocurrent density of 13.64 mA, ...
Tópico(s): Advanced Nanomaterials in Catalysis
2012 - American Chemical Society | Organic Letters
Yasuko Yoshida, Atsushi Kawaguchi, Norikazu Mataki, Koji Matsuzaki, Ryota Hokari, Atsuhiro Iwai, Shigeaki Nagao, Kazuro Itoh, Soichiro Miura,
Ulcerative colitis (UC) is occasionally complicated by massive hemorrhage. 1 Edwards FC Truelove SC The course and prognosis of ulcerative colitis. Gut. 1964; 5: 1-22 Crossref PubMed Scopus (296) Google Scholar Emergent surgery has been the treatment of first choice for such bleeding, as it has been for toxic megacolon and perforation. 1 Edwards FC Truelove SC The course and prognosis of ulcerative colitis. Gut. 1964; 5: 1-22 Crossref PubMed Scopus (296) Google Scholar Two cases of massive lower GI ...
Tópico(s): Gastrointestinal disorders and treatments
2001 - Elsevier BV | Gastrointestinal Endoscopy
Atsuhiro Kumabe, Takatsugu Kawase, Kouki Miura, Yuichiro Tada, Tatsuo Masubuchi, Shin-etsu Kamata, Shuji Tanada, Atsushi Kubo, Yasuo Tajima, Naoyuki Shigematsu,
Sebaceous carcinoma is a rare malignant tumor typically originating in the skin of the eyelid. We report an unusual case of sebaceous carcinoma originating in the parotid gland of a 23-year-old woman. The patient underwent F-18 2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (FDG PET/CT) to determine the initial clinical stage. FDG PET/CT revealed strong uptake in the primary lesion but neither regional lymphatic nor distant metastasis were seen. These findings allowed for ...
Tópico(s): Salivary Gland Tumors Diagnosis and Treatment
2010 - Lippincott Williams & Wilkins | Clinical Nuclear Medicine
Atsuhiro Miura, Eisuke Itakura, Akira Matsuura,
The telomere protects the ends of eukaryotic linear chromosomes, and its shortening or erosion is recognized as DNA damage, leading to loss of proliferation activity and, thus, cellular senescence at the population level. Here, using a GFP-based DNA damage checkpoint marker suited for single-cell observation of Saccharomyces cerevisiae cells, we correlated the checkpoint status of telomere-shortened cells with their behavior. We show that some cells possessing short telomeres retain proliferation ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2019 - Wiley | Genes to Cells
Akira Aoki, T. Yoshino, Fumihiko Akiyama, Mako Miura, Atsuhiro Kinoshita, Shigeru Oda, Hisashi Watanabe, Isao Ishikawa,
Tópico(s): Laser Applications in Dentistry and Medicine
2003 - Elsevier BV | International Congress Series
Koji Matsuzaki, Ryota Hokari, Shingo Kato, Yoshikazu Tsuzuki, Hirofumi Tanaka, Chie Kurihara, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Kinya Nagata, Soichiro Miura,
The pathogenesis of ulcerative colitis (UC) is unclear, but abnormal infiltration of T lymphocytes in the colonic mucosa has been implicated in the mucosal tissue damage. The abnormal cytokine production because of a T helper (h)1/Th2 imbalance may play an important role in continuing inflammation in the colonic mucosa. In the present study, the expression of chemokine receptor 5 (CCR5) as a Th1 marker and a chemoattractant receptor-homologs molecule expressed on Th2 cells (CRTH2) were investigated ...
Tópico(s): T-cell and B-cell Immunology
2003 - Wiley | Journal of Gastroenterology and Hepatology
Yoh Zen, Takahiko Fujii, Keita Itatsu, Kōichi Nakamura, Hiroshi Minato, Satomi Kasashima, Hiroshi Kurumaya, Kazuyoshi Katayanagi, Atsuhiro Kawashima, Shinji Masuda, Hideki Niwa, Takeshi Mitsui, Yasuyuki Asada, Shouji Miura, Tetsuo Ohta, Yasuni Nakanuma,
Recently, attention has been drawn to papillary neoplasm of the pancreatobiliary systems. In the pancreas, the disease entity of intraductal papillary mucinous neoplasm (IPMN-P) is widely recognized. In contrast, the pathological characteristics of biliary papillary tumors, such as biliary papilloma(tosis) and papillary cholangiocarcinoma, have not yet been well documented. In this study, we compared the pathological features and post-operative prognosis among biliary papillary tumors (10 cases of ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2006 - Lippincott Williams & Wilkins | Hepatology
Koichi Node, Takuya Kishi, Atsushi Tanaka, Hiroshi Itoh, Hiromi Rakugi, Yusuke Ohya, Katsuyuki Miura, Tomonori Okamura, Toshihiko Ishimitsu, Atsuhiro Ichihara, Masaaki Ito, Mitsuru Ohishi, Takayoshi Ohkubo, Hisashi Kai, Naoki Kashihara, Kazuomi Kario, Shigeyuki Saitoh, Takuya Tsuchihashi, Satoko Nakamura, Akira Nishiyama, Naoyuki Hasebe, Jitsuo Higaki, Kouichi Tamura, Yuhei Kawano, Takashi Yatabe, Sadayoshi Ito,
Tópico(s): Clinical practice guidelines implementation
2018 - Springer Nature | Hypertension Research
Takahiro Miura, Tomohiro Higashino, Shohei Saito, Atsuhiro Osuka,
Bisphosphorus complexes: Phosphorus complexes of octaphyrin were prepared upon the treatment of [36]octaphyrin(1.1.1.1.1.1.1.1) with PCl3 in the presence of amine and a small amount of water (see figure). Reversible redox interconversions between 38π- and 40π-electronic states were demonstrated. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. ...
Tópico(s): Porphyrin Metabolism and Disorders
2009 - Wiley | Chemistry - A European Journal
Yusuke Ohya, Kazuomi Kario, Hiroshi Itoh, Akira Nishiyama, Toshihiko Ishimitsu, Atsuhiro Ichihara, Hisashi Kai, Naoki Kashihara, Tomohiro Katsuya, Katsuyuki Miura, Masashi Mukoyama, Satoko Nakamura, Koichi Node, Mitsuru Ohishi, Shigeyuki Saito, Hirotaka Shibata, Tatsuo Shimosawa, Kouichi Tamura, Ḱazunori Toyoda, Mohd Arifin Mohd Ali, Yook Chin Chia, Godwin Constantine, Erwinanto Erwinanto, Sang‐Hyun Ihm, Hsien‐Li Kao, Huynh Van Minh, S N Narasingan, Deborah Ignacia D. Ona, Saulat Siddique, Apichard Sukonthasarn, Boon Wee Teo, Tsolmon Unurjargal, Ji‐Guang Wang, Tzung‐Dau Wang, Hiromi Raukgi,
Tópico(s): Nutritional Studies and Diet
2021 - Springer Nature | Hypertension Research
Yong Ding, Atsuhiro Kondoh, Yoshinari Miura, Tokuro Nanba,
The reason for the optical frequency doubling in the 70Ga2S3–30La2S3 glass is investigated. The tetragonal Ga6La10/3S14 phase due to crystallization of the glass is responsible for the frequency doubling. Dense and transparent Ga6La10/3S14 crystalline thin films have been prepared by means of the controlled surface treatment of the glass due to an ultrasonic surface treatment. The effective second-order nonlinear optical susceptibilities of the crystalline thin films are analyzed.
Tópico(s): Optical and Acousto-Optic Technologies
1998 - American Institute of Physics | Applied Physics Letters
Shingo Kato, Kazuro Itoh, Mitsuko Ochiai, Atsuhiro Iwai, Yeongji Park, Satoshi Hata, Kyoko Takeuchi, Masataka Ito, Junko Imaki, Soichiro Miura, Koji Yakabi, Makio Kobayashi,
Abstract Background: Under inflammatory conditions with strong oxidative stresses, advanced glycation end‐products (AGE), carbonyl compounds, are produced. The concentration of pentosidine, an AGE, reportedly correlates with complications of diabetes mellitus and worsening of rheumatoid arthritis, but its role in the pathogenesis of inflammatory bowel diseases (IBD) is unclear. Methods: Immunohistochemistry was performed with antibodies against pentosidine, and 8‐OH‐2‐deoxyguanosine. The urinary concentration ...
Tópico(s): Chronic Kidney Disease and Diabetes
2008 - Wiley | Journal of Gastroenterology and Hepatology
Shingo Kato, Yoshikazu Tsuzuki, Ryota Hokari, Yoshikiyo Okada, Jun‐ichi Miyazaki, Koji Matsuzaki, Atsuhiro Iwai, Atsushi Kawaguchi, Shigeaki Nagao, Kazuro Itoh, Hidekazu Suzuki, Toshitaka Nabeshima, Soichiro Miura,
Nociceptin/orphanin (Noc/oFQ), endogenous agonist for nociceptin receptor (NOR), is thought to be a stimulator of neurogenic inflammation. We investigated the possible role of Noc/oFQ in the development of colitis using NOR-deficient mice treated with dextran sulfate sodium (DSS). Colitis was significantly improved in NOR-deficient mice against wild-type mice. Expression level of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and infiltrating cells also significantly decreased in NOR-deficient ...
Tópico(s): Cardiovascular, Neuropeptides, and Oxidative Stress Research
2005 - Elsevier BV | Journal of Neuroimmunology
Takashi Kato, Hiroshi Tsuji, T. Ando, Yoshikazu Takahashi, Hideo Nakajima, M. Sugimoto, T. Isono, N. Koizumi, K. Kawano, M. Oshikiri, K. Hamada, Y. Nunoya, K. Matsui, T. Shinba, Y. Tsuchiya, G. Nishijima, H. Kubo, Eiji Hara, H. Hanawa, K. Imahashi, Kiichi Ootsu, Y. Uno, T. Oouchi, Junichi OKAYAMA, Tsutomu Kawasaki, M Kawabe, S. Seki, Katsutoshi Takano, Y. Takaya, F. Tajiri, Atsuhiro Tsutsumi, T. Nakanura, H. Hanawa, Hiroshi Wakabayashi, Kenji Nishii, N. Hosogane, M. Matsukawa, Yushi Miura, T. Terakado, Jun Okano, Kazuhiko Shimada, Masaru Yamashita, K. Arai, T. Ishigouoka, A. Ninomiya, K. Okuno, D. Bessete, H. Takigami, N. Martovetsky, Philip C. Michael, M. Takayasu, M. Ricci, R. Zanino, Laura Savoldi, G. Zahn, A. Martínez, R. Maix,
The largest pulsed superconducting coils ever built, the Central Solenoid (CS) Model Coil and Central Solenoid Insert Coil were successfully developed and tested by international collaboration under the R&D activity of the International Thermonuclear Experimental Reactor (ITER), demonstrating and validating the engineering design criteria of the ITER Central Solenoid coil. The typical achievement is to charge the coil up to the operation current of 46 kA, and the maximum magnetic field to 13 T with ...
Tópico(s): Magnetic confinement fusion research
2001 - Elsevier BV | Fusion Engineering and Design
Changhee Lee, Hiroyuki Yoshida, Yuki Miura, Atsuhiro Fujii, Masanori Ozaki,
The authors have demonstrated the local alignment of nematic liquid crystal with local micro-grating structure fabricated by the curing of an ultraviolet curable material via a three dimensional micro-fabrication technique known as two photon excitation direct laser writing [1]. The molecular alignment of the nematic liquid crystals on the fabricated micro-grating structures was firstly investigated by the observations of a local twisted nematic region in a liquid crystal cell made of a substrate ...
Tópico(s): Photonic Crystals and Applications
2008 - Institute of Electronics, Information and Communication Engineers | IEICE Transactions on Electronics
Tomohiro Higashino, Jong Min Lim, Takahiro Miura, Shohei Saito, Jae‐Yoon Shin, Dongho Kim, Atsuhiro Osuka,
Aromaticity with a twist: The reversal of Möbius aromaticity occurs by changing the number of π electrons between [4n+2] and [4n] in monophosphorus complexes of [28]hexaphyrins and bisphosphorus complexes of [30]hexaphyrins. The 30π Möbius antiaromatic bisphosporus[30]hexaphyrins (see picture) were determined to be the first structurally characterized Möbius antiaromatic systems, which are rigid, neutral, and stable. Detailed facts of importance to specialist readers are published as "Supporting Information". ...
Tópico(s): Photochromic and Fluorescence Chemistry
2010 - Wiley | Angewandte Chemie International Edition