Naoyuki Masuda, Shunsuke Tanba, Atsushi Sugie, Daiki Monguchi, Nagatoshi Koumura, Kohjiro Hara, Atsunori Mori,
... CH Arylation and Halogen ExchangeNaoyuki Masuda†, Shunsuke Tanba†, Atsushi Sugie†, Daiki Monguchi†, Nagatoshi Koumura‡, Kohjiro Hara‡, and Atsunori ...
Tópico(s): Polyoxometalates: Synthesis and Applications
2009 - American Chemical Society | Organic Letters
Atsushi Sugie, Takashi Somete, Kiyoshi Kanie, Atsushi Muramatsu, Atsunori Mori,
The reaction of HAuCl(4).4H(2)O and n-C(12)H(25)SH with 1 equiv. of Et(3)SiH in an organic solvent affords spherical gold nanoparticles (AuNPs) with narrow dispersity.
Tópico(s): Gold and Silver Nanoparticles Synthesis and Applications
2008 - Royal Society of Chemistry | Chemical Communications
Y. Matsuo, Kenshiro Iwasa, Yosohiro Sugie, Atsushi Mineshige, Hisanao Usami,
Thin films of silylated graphite oxide were obtained from a chloroform/cyclohexane dispersion of n-hexadecylamine-intercalated silylated graphite oxide by a casting method at a low temperature. Carbon-based thin films were obtained from the pyrolysis of the resulting films under a reduced pressure at 500 °C or higher temperatures. The resulting samples were well adhered to the substrate because of the presence of silicon containing species as a “glue”. The resistivity decreased with an increase in ...
Tópico(s): Advancements in Battery Materials
2010 - Elsevier BV | Carbon
Akira Suda, Shigeto Namiuchi, Tomohiro Kawaguchi, Taro Nihei, Toru Takii, K Saji, T. Sugie, Atsushi Kato, Hiroaki Shimokawa,
Tópico(s): Acute Myocardial Infarction Research
2016 - Springer Science+Business Media | Heart and Vessels
Masamune Sakamoto, Kazunori Sasaki, Atsushi Sugie, Yohei Nitta, Tetsuaki Kimura, Semra Gürsoy, Tayfun Çinleti, Mizue Iai, Toru Sengoku, Kazuhiro Ogata, Atsushi Suzuki, Nobuhiko Okamoto, Kazuhiro Iwama, Naomi Tsuchida, Yuri Uchiyama, Eriko Koshimizu, Atsushi Fujita, Kohei Hamanaka, Satoko Miyatake, Takeshi Mizuguchi, Masataka Taguri, Shuuichi Ito, Hidehisa Takahashi, Noriko Miyake, Naomichi Matsumoto,
Abstract An optimal Golgi transport system is important for mammalian cells. The adenosine diphosphate (ADP) ribosylation factors (ARF) are key proteins for regulating cargo sorting at the Golgi network. In this family, ARF3 mainly works at the trans-Golgi network (TGN), and no ARF3-related phenotypes have yet been described in humans. We here report the clinical and genetic evaluations of two unrelated children with de novo pathogenic variants in the ARF3 gene: c.200A > T (p.Asp67Val) and c.296G & ...
Tópico(s): RNA regulation and disease
2021 - Oxford University Press | Human Molecular Genetics
Atsushi Sugie, Tomomi Hatta, Kiyoshi Kanie, Atsushi Muramatsu, Atsunori Mori,
Abstract The reaction of chloroauric(III) acid and dodecanethiol with THF solution of 2-propylmagnesium bromide furnishes thiol-capped gold nanoparticles. The obtained nanoparticles are spherical and exhibit average diameter of 5.5±0.61 nm. Synthesis of the nanoparticles are also carried out by using other Grignard reagents and organometallic reagents.
Tópico(s): Innovative Microfluidic and Catalytic Techniques Innovation
2009 - Oxford University Press | Chemistry Letters
Samuel D. Chauvin, Shoichiro Ando, Joe A. Holley, Atsushi Sugie, Fang Zhao, Subhajit Poddar, Rei Kato, Cathrine A. Miner, Yohei Nitta, Siddharth R. Krishnamurthy, Rie Saito, Yue Ning, Yuya Hatano, Sho Kitahara, Shin Koide, William A. Stinson, Jiayuan Fu, Nehalee Surve, Lindsay Kumble, Wei Qian, О. М. Поліщук, Prabhakar S. Andhey, Cindy Chiang, Guanqun Liu, Ludovic Colombeau, Raphaël Rodriguez, Nicolas Manel, Akiyoshi Kakita, Maxim N. Artyomov, D. Schultz, P Coates, Elisha Roberson, Yasmine Belkaid, Roger A. Greenberg, Sara Cherry, Michaela U. Gack, Tristan Hardy, Osamu Onodera, Taisuke Kato, Jonathan J. Miner,
Abstract Age-related microangiopathy, also known as small vessel disease (SVD), causes damage to the brain, retina, liver, and kidney. Based on the DNA damage theory of aging, we reasoned that genomic instability may underlie an SVD caused by dominant C-terminal variants in TREX1, the most abundant 3′−5′ DNA exonuclease in mammals. C-terminal TREX1 variants cause an adult-onset SVD known as retinal vasculopathy with cerebral leukoencephalopathy (RVCL or RVCL-S). In RVCL, an aberrant, C-terminally ...
Tópico(s): Retinal Development and Disorders
2024 - Nature Portfolio | Nature Communications
Kenji Funaki, Ma Su, Shotaro Kawamura, Atsushi Miyazaki, Atsushi Sugie, Atsunori Mori, Atsushi Muramatsu, Kiyoshi Kanie,
Ionic liquids (ILs) bearing tetrahydropyran-2H-yl (THP)-protected thiol moieties were designed and synthesized as extractants for Pd(II)-selective extraction into an IL phase from a mixed aqueous HCl solution of Pd(II) and Pt(IV) salts. 1H NMR measurements revealed that metal-selective THP-deprotection by the Pd(II) salt played a critical role to introduce the Pd(II)-selective extraction ability.
Tópico(s): Analytical chemistry methods development
2017 - Oxford University Press | Chemistry Letters
Mamiko Yamada, Yohei Nitta, Tomoko Uehara, Hisato Suzuki, Fuyuki Miya, Toshiki Takenouchi, Masaru Tamura, Shinya Ayabe, Atsushi Yoshiki, Akiteru Maeno, Yumiko Saga, Tamio Furuse, Ikuko Yamada, Nobuhiko Okamoto, Kenjiro Kosaki, Atsushi Sugie,
DExH-box helicases are involved in unwinding of RNA and DNA. Among the 16 DExH-box genes, monoallelic variants of DHX16, DHX30, DHX34, and DHX37 are known to be associated with neurodevelopmental disorders. In particular, DHX30 is well established as a causative gene for neurodevelopmental disorders. Germline variants of DHX9, the closest homolog of DHX30, have not been reported until now as being associated with congenital disorders in humans, except that one de novo heterozygous variant, p.(Arg1052Gln) ...
Tópico(s): RNA Research and Splicing
2023 - Elsevier BV | European Journal of Medical Genetics
Annalisa Vetro, Cristiana Pelorosso, Simona Balestrini, Alessio Masi, Sophie Hambleton, Emanuela Argilli, Valerio Conti, Simone Giubbolini, Rebekah Barrick, Gaber Bergant, Karin Writzl, Emilia K. Bijlsma, Theresa Brunet, Pilar Cacheiro, Davide Mei, Anita Devlin, Mariëtte J.V. Hoffer, Keren Machol, Guido Mannaioni, Masamune Sakamoto, Manoj P. Menezes, Thomas Courtin, Elliott H. Sherr, Riccardo Parra, Ruth Richardson, Tony Roscioli, Marcello Scala, Celina von Stülpnagel, Damian Smedley, Francesca Pochiero, Francesco Mari, Venkateswaran Ramesh, Valeria Capra, Maria Margherita Mancardi, Boris Keren, C. Mignot, Matteo Lulli, Kendall C. Parks, Helen Griffin, Melanie Brugger, Vincenzo Nigro, Mitsuhiro Kato, Reiko Koichihara, Borut Peterlin, Mitsuhiro Kato, Ryuto Maki, Yohei Nitta, John C. Ambrose, Prabhu Arumugam, R. Bevers, Marta Bleda, F. Boardman-Pretty, C. R. Boustred, Helen Brittain, Matthew A. Brown, Mark J. Caulfield, G. C. Chan, Adam Giess, John N. Griffin, Angela Hamblin, Bingyang Shi, Tim Hubbard, Robert B. Jackson, Louise J. Jones, Dalia Kasperavičiūtė, Melis Kayikci, Athanasios Kousathanas, L. Lahnstein, Anna Lakey, S. E. A. Leigh, I. U. S. Leong, Javier Ferreiros, F. Maleady-Crowe, Meriel McEntagart, Federico Minneci, Jonathan Mitchell, Loukas Moutsianas, Michael P. Mueller, Nirupa Murugaesu, Anna C. Need, Peter O’Donovan, Chris A. Odhams, Christine Patch, D. Perez-Gil, Monica Pereira, J. Pullinger, T. Rahim, Augusto Rendon, Tim Rogers, K. Savage, Kushmita Sawant, Richard H. Scott, Afshan Siddiq, A. Sieghart, Samuel C. Smith, Alona Sosinsky, Alexander Stuckey, M. Tanguy, Ana Lisa Taylor Tavares, Ellen Thomas, Simon R. Thompson, Arianna Tucci, M. J. Welland, Eleanor Williams, Katarzyna Witkowska, S. M. Wood, Magdalena Zarowiecki, Annalaura Torella, Jun Tohyama, Reiko Koichihara, Keisuke Hamada, Kazuhiro Ogata, Takashi Suzuki, Atsushi Sugie, Jasper J. van der Smagt, Koen L.I. van Gassen, Stéphanie Valence, Emma Vittery, Stephen Malone, Mitsuhiro Kato, Naomichi Matsumoto, Gian Michele Ratto, Renzo Guerrini,
Summary By converting physical forces into electrical signals or triggering intracellular cascades, stretch-activated ion channels allow the cell to respond to osmotic and mechanical stress. Knowledge of the pathophysiological mechanisms underlying associations of stretch-activated ion channels with human disease is limited. Here, we describe 17 unrelated individuals with severe early-onset developmental and epileptic encephalopathy (DEE), intellectual disability, and severe motor and cortical visual impairment ...
Tópico(s): Ion Transport and Channel Regulation
2023 - Elsevier BV | The American Journal of Human Genetics
The use of Drosophila in neurodegenerative disease research has contributed to the identification of modifier genes for the pathology. The basis for neurodegenerative disease occurrence in Drosophila is the conservation of genes across species and the ability to perform rapid genetic analysis using a compact brain. Genetic findings previously discovered in Drosophila can reveal molecular pathologies involved in human neurological diseases in later years. Disease models using Drosophila began to ...
Tópico(s): Neurobiology and Insect Physiology Research
2022 - Landes Bioscience | Fly
Yohei Nitta, Daisuke Yamazaki, Atsushi Sugie, Makoto Hiroi, Tetsuya Tabata,
Tópico(s): Endoplasmic Reticulum Stress and Disease
2016 - Elsevier BV | Developmental Biology
Atsushi Sugie, Satoko Hakeda‐Suzuki, Emiko Suzuki, Marion Silies, Mai Shimozono, Christoph Möhl, Takashi Suzuki, Gaia Tavosanis,
Neural activity contributes to the regulation of the properties of synapses in sensory systems, allowing for adjustment to a changing environment. Little is known about how synaptic molecular components are regulated to achieve activity-dependent plasticity at central synapses. Here, we found that after prolonged exposure to natural ambient light the presynaptic active zone in Drosophila photoreceptors undergoes reversible remodeling, including loss of Bruchpilot, DLiprin-α, and DRBP, but not of ...
Tópico(s): Hippo pathway signaling and YAP/TAZ
2015 - Cell Press | Neuron
Kanta Fuji, Shunsuke Tamba, Keisuke Shono, Atsushi Sugie, Atsunori Mori,
Revisiting Murahashi coupling, we found that it effectively allows polymerization of lithiated (hetero)arenes by nickel(II)-catalyzed polycondensation. Deprotonative polymerization of 2-chloro-3-substituted thiophene with n-butyllithium gave head-to-tail-type poly(3-substituted thiophene). Poly(1,4-arylene)s were obtained by the reaction of the corresponding dibromides through lithium–bromine exchange. A lithiated thiophene derivative obtained via deprotonative halogen dance also underwent polymerization ...
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
2013 - American Chemical Society | Journal of the American Chemical Society
Sandra Berger-Müller, Atsushi Sugie, Fumio Takahashi, Gaia Tavosanis, Satoko Hakeda‐Suzuki, Takashi Suzuki,
A hallmark of the central nervous system is its spatial and functional organization in synaptic layers. During neuronal development, axons form transient contacts with potential post-synaptic elements and establish synapses with appropriate partners at specific layers. These processes are regulated by synaptic cell-adhesion molecules. In the Drosophila visual system, R7 and R8 photoreceptor subtypes target distinct layers and form en passant pre-synaptic terminals at stereotypic loci of the axonal ...
Tópico(s): Retinal Development and Disorders
2013 - Public Library of Science | PLoS ONE
Shunsuke Tamba, Kanta Fuji, Hikaru Meguro, Shuji Okamoto, Tadashi Tendo, Ryo Komobuchi, Atsushi Sugie, Takashi Nishino, Atsunori Mori,
Abstract High-molecular-weight head-to-tail-type regioregular polythiophenes are synthesized by [CpNiCl(SIPr)]-catalyzed dehydrobrominative polycondensation. Polycondensation of 2-bromo-3-hexylthiophene at the C–H bond proceeds with an equimolar amount of TMPMgCl·LiCl and a catalytic amount of [CpNiCl(SIPr)] to afford the regioregular poly(3-hexylthiophene) (HT-P3HT) with up to Mw = 815000. A self-standing HT-P3HT film is obtained with the regioregular HT-P3HT of Mw = 414000, while the attempted formation ...
Tópico(s): Organoboron and organosilicon chemistry
2013 - Oxford University Press | Chemistry Letters
Atsunori Mori, Shunsuke Tamba, Kenji Ide, Keisuke Shono, Atsushi Sugie,
Deprotonative metalation of chlorothiophene takes place with a catalytic amount of cis -2,6-dimethylpiperidine (DMP) and an alkyl Grignard reagent at room temperature for three hours to give the corresponding thienyl Grignard reagent. Polymerization leading to head-to-tail-type poly(3-substituted thiophene) with the thus metalated chlorothiophene proceeds in the presence of a nickel catalyst bearing an N -heterocyclic carbene (NHC) ligand. Palladium-catalyzed cross-coupling reaction with aryl bromides ...
Tópico(s): Inorganic Chemistry and Materials
2013 - Thieme Medical Publishers (Germany) | Synlett
Shunsuke Tamba, Shinobu Mitsuda, Fujimaru Tanaka, Atsushi Sugie, Atsunori Mori,
Dehydrobrominative polycondensation of 2-bromo-3-hexylthiophene proceeded with TMPMgBr·LiBr and (TMP)2Mg·2LiBr, formed by LiTMP and MgBr2, which was found to serve as a surrogate of the Knochel–Hauser base TMPMgCl·LiCl, and head-to-tail-type regioregular poly(3-hexylthiophene) was obtained with high efficiency. The regioregular poly(3-hexylthiophene) was also found to be obtained by one-shot addition of 2-bromo-3-hexylthiophene as a monomer, magnesium amide, and a nickel catalyst, suggesting that ...
Tópico(s): Synthetic Organic Chemistry Methods
2012 - American Chemical Society | Organometallics
Shotaro Nishio, Takashi Somete, Atsushi Sugie, T. Kobayashi, Tsuyoshi Yaita, Atsunori Mori,
Clipping by ring-closing metathesis freezes rotation of a C-C bond to result in forming axial chirality. Treatment of bisbenzimidazole bearing an N-(3-butenyl) substituent with a Grubbs' catalyst undergoes ring-closing metathesis, in which the stereochemistry of the thus formed olefin was exclusively E-form. Analysis by HPLC with a chiral stationary column confirmed clear baseline separation of each enantiomer.
Tópico(s): Synthesis and Catalytic Reactions
2012 - American Chemical Society | Organic Letters
Shota Tanaka, Daiki Tanaka, Go Tatsuta, Kohei Murakami, Shunsuke Tamba, Atsushi Sugie, Atsunori Mori,
Abstract The synthesis of linear and branched oligothiophenes of well‐defined structures is performed with regioselective deprotonation of 3‐substituted thiophenes and nickel‐catalyzed cross‐coupling of the thus formed metalated species with a bromothiophene. The reaction of 3‐hexylthiophene with EtMgCl and 2,2,6,6‐tetramethylpiperidine (TMP‐H, 10 mol %) induces the metalation selectively at the 5‐position by use of the catalytically generated hindered magnesium amide (TMPMgCl) and the subsequent reaction ...
Tópico(s): Synthetic Organic Chemistry Methods
2012 - Wiley | Chemistry - A European Journal
Timothy J. Brown, Atsushi Sugie, Marina G. D. Leed, Ross A. Widenhoefer,
Abstract A family of seven cationic gold complexes that contain both an alkyl substituted π‐allene ligand and an electron‐rich, sterically hindered supporting ligand was isolated in >90 % yield and characterized by spectroscopy and, in three cases, by X‐ray crystallography. Solution‐phase and solid‐state analysis of these complexes established preferential binding of gold to the less substituted CC bond of the allene and to the allene π face trans to the substituent on the uncomplexed allenyl CC ...
Tópico(s): Cyclopropane Reaction Mechanisms
2012 - Wiley | Chemistry - A European Journal
Shota Tanaka, Shunsuke Tamba, Daiki Tanaka, Atsushi Sugie, Atsunori Mori,
Iterative growth of thiophene oligomers by single-step extensions has been realized by regioselective metalation of 3-substituted thiophenes with the Knochel–Hauser base (TMPMgCl·LiCl) and coupling with bromothiophene using a nickel catalyst. Treatment of 3-hexylthiophene with TMPMgCl·LiCl induces metalation at the 5-position selectively. Subsequent addition of 2-bromo-3-hexylthiophene and a nickel catalyst leads to the corresponding bithiophene. The obtained bithiophene is converted to the terthiophene ...
Tópico(s): Catalytic Cross-Coupling Reactions
2011 - American Chemical Society | Journal of the American Chemical Society
Shunsuke Tamba, Keisuke Shono, Atsushi Sugie, Atsunori Mori,
Polymerization of 2-chloro-3-substituted thiophenes proceeded with a stoichiometric amount of magnesium amide, TMPMgCl·LiCl, or a combination of a Grignard reagent and a catalytic amount of secondary amine in the presence of a nickel catalyst. Although the nickel-catalyzed polymerization with NiCl(2)dppe, which exhibited high catalytic activity in the reaction of bromothiophenes, was less effective, use of a nickel catalyst bearing N-heterocyclic carbene as a ligand was found to induce polymerization ...
Tópico(s): N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
2011 - American Chemical Society | Journal of the American Chemical Society
Atsushi Sugie, Daiki Umetsu, Tetsuo Yasugi, Karl‐Friedrich Fischbach, Tetsuya Tabata,
Topographic maps, which maintain the spatial order of neurons in the order of their axonal connections, are found in many parts of the nervous system. Here, we focus on the communication between retinal axons and their postsynaptic partners, lamina neurons, in the first ganglion of the Drosophila visual system, as a model for the formation of topographic maps. Post-mitotic lamina precursor cells differentiate upon receiving Hedgehog signals delivered through newly arriving retinal axons and, before ...
Tópico(s): Neurobiology and Insect Physiology Research
2010 - The Company of Biologists | Development
Tetsuo Yasugi, Atsushi Sugie, Daiki Umetsu, Tetsuya Tabata,
During neurogenesis in the medulla of the Drosophila optic lobe, neuroepithelial cells are programmed to differentiate into neuroblasts at the medial edge of the developing optic lobe. The wave of differentiation progresses synchronously in a row of cells from medial to the lateral regions of the optic lobe, sweeping across the entire neuroepithelial sheet; it is preceded by the transient expression of the proneural gene lethal of scute [l(1)sc] and is thus called the proneural wave. We found that ...
Tópico(s): Axon Guidance and Neuronal Signaling
2010 - The Company of Biologists | Development
Atsunori Mori, Shunsuke Tanba, Atsushi Sugie, Naoyuki Masuda, Daiki Monguchi, Nagatoshi Koumura, Kohjiro Hara,
Iterative extension of the thiophene ring unit leads to oligothiophenes.The coupling reaction at the CH bond of thiophene with halo-thiophene occurs at the 5-position of 2-bromothiophene with 2-iodothiophene in the presence of a palladium catalyst and AgNO 3 /KF as an activator to give the corresponding bithiophene, whose carbon-bromine bond remains.Halogen exchange converts the bromine atom to iodide, which also allows further reaction to form thiophene-thiophene bond.Oligothiophenes are obtained ...
Tópico(s): Organic Chemistry Cycloaddition Reactions
2010 - Elsevier BV | Heterocycles
Timothy J. Brown, Atsushi Sugie, M.G. Dickens, Ross A. Widenhoefer,
The cationic gold π-allene complex {[P(t-Bu)2o-biphenyl]Au[η2-H2C═C═C(CH3)2]}+SbF6− was isolated in 98% yield from reaction of 3-methyl-1,2-butadiene with a mixture of [P(t-Bu)2o-biphenyl]AuCl and AgSbF6 and was characterized by X-ray crystallography and variable-temperature NMR spectroscopy. These studies revealed preferential binding of gold to the less substituted C═C bond of the allene in both the solid state and solution and also revealed fluxional behavior consistent with π-face exchange of the ...
Tópico(s): Cyclopropane Reaction Mechanisms
2010 - American Chemical Society | Organometallics
Atsushi Sugie, Hirotoshi Furukawa, Yuji Suzaki, Kohtaro Osakada, Munetaka Akita, Daiki Monguchi, Atsunori Mori,
Mechanistic studies on palladium-catalyzed CH arylation of thiophenes which has been shown by our group are carried out by a stoichiometric reaction of organometallic complexes. The reaction of ary...
Tópico(s): Catalytic Cross-Coupling Reactions
2009 - Oxford University Press | Bulletin of the Chemical Society of Japan
Abstract CH arylation of five-membered heteroaromatic compounds such as thiazoles and thiophenes recently developed by the authors is reviewed. The reaction of thiazole with aryl iodides in the presence of a palladium/copper catalyst system and tetrabutylammonium fluoride causes CH arylation at the 2-position of thiazole. The reaction of 2-arylthiazole with aryl iodide by the catalysis of a palladium complex with silver(I) fluoride induces CH arylation at the 5-position. The reactions allow preparation ...
Tópico(s): Catalytic Alkyne Reactions
2008 - Oxford University Press | Bulletin of the Chemical Society of Japan
Nobuyuki Mizuno, Atsushi Sugie, Fuminori Kobayashi, Shigeo Takumi,
Cold acclimation is an adaptive process for acquiring cold/freezing tolerance in wheat. To clarify the cultivar difference of freezing tolerance, we compared mitochondrial respiration activity and the expression profile of alternative oxidase (AOX) genes under low-temperature conditions using two common wheat cultivars differing in freezing tolerance. During cold acclimation, the respiration capacity of the alternative pathway significantly increased in a freezing-tolerant cultivar compared with ...
Tópico(s): Wheat and Barley Genetics and Pathology
2007 - Elsevier BV | Journal of Plant Physiology