Arie Steinvil, Nelson L. Bernardo, Toby Rogers, Edward Koifman, Kyle Buchanan, M. Chadi Alraies, Christian Shults, Rebecca Torguson, Petros G. Okubagzi, Augusto D. Pichard, Lowell F. Satler, Itsik Ben‐Dor, Ron Waksman,
Our aim was to describe our experience with the use of an ePTFE-covered nitinol self-expanding stent graft (GORE® VIABAHN® Endoprosthesis, Gore Medical, USA) placed in the common femoral artery for the treatment of suture-mediated pre-closure device failure following transcatheter aortic valve replacement (TAVR). Access site–related vascular complications (VC) following sheath removal related to pre-closure device failure during TAVR are common and treatment options may vary. We performed an observational ...
Tópico(s): Vascular Procedures and Complications
2016 - Elsevier BV | Cardiovascular revascularization medicine
Arie Steinvil, Kyle Buchanan, Sarkis Kiramijyan, Elizabeth Bond, Toby Rogers, Edward Koifman, Christian Shults, Linzhi Xu, Rebecca Torguson, Petros G. Okubagzi, Augusto D. Pichard, Lowell F. Satler, Itsik Ben‐Dor, Ron Waksman,
The impact of frailty assessment on outcomes in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. Our aim was to evaluate the individual effect of each frailty test and the utility of an additive frailty index score on short- and long-term survival following TAVR. Retrospective analysis of consecutive TAVR patients for whom a complete set of frailty tests was obtained: algorithm defined grip strength and 5-m walking tests, body mass index <20 kg/m2, Katz activities ...
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2018 - Elsevier BV | American Heart Journal
Johanna Lepeule, Marie-Abele Catherine Bind, Andrea Baccarelli, Petros Koutrakis, Letizia Tarantini, Augusto A. Litonjua, David Sparrow, Pantel Vokonas, Joel Schwartz,
Few studies have been performed on pulmonary effects of air pollution in the elderly--a vulnerable population with low reserve capacity--and mechanisms and susceptibility factors for potential effects are unclear.We evaluated the lag structure of air pollutant associations with lung function and potential effect modification by DNA methylation (< or ≥ median) at 26 individual CpG sites in nine candidate genes in a well-characterized cohort of elderly men.We measured forced vital capacity (FVC), forced ...
Tópico(s): Climate Change and Health Impacts
2014 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Toby Rogers, Arie Steinvil, Kyle Buchanan, M. Chadi Alraies, Edward Koifman, Jiaxiang Gai, Rebecca Torguson, Petros Okubagzi, Itsik Ben‐Dor, Augusto D. Pichard, Lowell F. Satler, Ron Waksman,
Objectives To evaluate balloon‐expandable and self‐expanding third‐generation transcatheter aortic valve replacement (TAVR) devices according to patient selection criteria and outcomes. Background Two competing third‐generation TAVR technologies are currently commercially available in the US. There are no published head‐to‐head comparisons of the relative performance of these two devices. Methods 257 consecutive patients undergoing TAVR with a third‐generation balloon‐expandable (Edwards Sapien 3) ...
Tópico(s): Aortic Disease and Treatment Approaches
2017 - Wiley | Journal of Interventional Cardiology
Toby Rogers, Mithun Devraj, Athanasios Thomaides, Arie Steinvil, Michael J. Lipinski, Kyle Buchanan, M. Chadi Alraies, Edward Koifman, Jiaxiang Gai, Rebecca Torguson, Petros Okubagzi, Itsik Ben‐Dor, Augusto D. Pichard, Lowell F. Satler, Ron Waksman,
Permanent pacemaker (PPM) implantation remains common after transcatheter aortic valve implantation (TAVI). Invasive electrophysiology studies (EPSs) may reduce PPM implantation rates by identifying patients who do not require long-term pacing. At our institution, a new strategy in which patients with equivocal indications for pacing underwent EPSs to determine the need for PPM implantation was adopted. We compared baseline demographics, TAVI procedural details, and outcomes in patients without any ...
Tópico(s): Cardiac Imaging and Diagnostics
2018 - Elsevier BV | The American Journal of Cardiology
Israel M. Barbash, Sa’ar Minha, Itsik Ben‐Dor, Danny Dvir, Marco A. Magalhães, Rebecca Torguson, Petros Okubagzi, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Transcatheter aortic valve implantation (TAVI) is associated with improved left ventricular (LV) function in patients with aortic stenosis (AS) and LV dysfunction; however, the outcome after TAVI of patients with low left ventricular ejection fraction (LVEF) is unclear. This study aimed to characterize the baseline, procedural, and long-term outcomes of patients with low LVEF undergoing TAVI and to assess the prognostic utility of pre-TAVI balloon aortic valvuloplasty (BAV) and dobutamine stress echocardiography ( ...
Tópico(s): Coronary Interventions and Diagnostics
2014 - Elsevier BV | The American Journal of Cardiology
Israel M. Barbash, Ricardo O. Escárcega, Sa’ar Minha, Itsik Ben‐Dor, Rebecca Torguson, Steven A. Goldstein, Dee Dee Wang, Petros Okubagzi, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Limited amount of data suggest that patients with aortic stenosis and pulmonary hypertension (PH) who undergo transcatheter aortic valve replacement (TAVR) experience decrease in PH postprocedure. Inconsistent use of systolic pulmonary artery pressure cut-off values in previous studies limits our ability to draw meaningful conclusions regarding the prognostic role of PH in assessment of TAVR candidates. A total of 415 consecutive patients who underwent TAVR were included in the present study. Two ...
Tópico(s): Cardiovascular Function and Risk Factors
2015 - Elsevier BV | The American Journal of Cardiology
Kyle Buchanan, Toby Rogers, Arie Steinvil, Edward Koifman, Linzhi Xu, Rebecca Torguson, Petros G. Okubagzi, Christian Shults, Augusto D. Pichard, Itsik Ben‐Dor, Lowell F. Satler, Ron Waksman, Federico M. Asch,
The aim of this study was to determine the prognostic value of contractile reserve (CR) at baseline in patients with low-flow, low-gradient severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).Patients with severe AS, left ventricular dysfunction, and low transaortic gradient are at high risk for mortality during surgical aortic valve replacement (SAVR). Furthermore, patients without CR have been shown to have perioperative mortality comparable to that of patients treated ...
Tópico(s): Cardiac Structural Anomalies and Repair
2018 - Wiley | Catheterization and Cardiovascular Interventions
Itsik Ben‐Dor, Paige Craig, Rebecca Torguson, Toby Rogers, Kyle Buchanan, Shreejana Pokharel, Jiaxiang Gai, Petros G. Okubagzi, Lowell F. Satler, Augusto D. Pichard, Nevin C. Baker, Ron Waksman,
Evaluate the safety of MynxGrip® for common femoral vein closure. This is a multicenter, randomized, prospective study of 208 patients who were slated to undergo diagnostic/interventional procedures via femoral venous access. Patients were randomized 1:1 to receive venous hemostasis via MynxGrip® (n = 104) or manual compression (n = 104) utilizing 5, 6, and 7 Fr sheaths. Bilateral calf and thigh circumferences were measured serially. Patients were followed up through hospital discharge. There were no ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2018 - Elsevier BV | Cardiovascular revascularization medicine
Israel M. Barbash, Danny Dvir, Itsik Ben‐Dor, Paul J. Corso, Steven A. Goldstein, Dee Dee Wang, Elizabeth Bond, Petros G. Okubagzi, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Recent reports indicate that the transapical approach for transcatheter aortic valve replacement may be associated with elevated cardiac enzymes, poor recovery of left ventricular function, and poor outcomes. The aim of this study was to evaluate whether transapical access is associated with apical dysfunction and to assess consequences on patient outcomes.In patients undergoing transapical aortic valve replacement, apical regional function was retrospectively assessed using the three standard echocardiographic ...
Tópico(s): Cardiovascular Function and Risk Factors
2013 - Elsevier BV | Journal of the American Society of Echocardiography
Diane R. Gold, Gary Adamkiewicz, Syed Hasan Arshad, Juan C. Celedón, Martin D. Chapman, Ginger L. Chew, Donald N. Cook, Adnan Ćustović, Ulrike Gehring, James E. Gern, Christine Cole Johnson, Suzanne Kennedy, Petros Koutrakis, Brian P. Leaderer, Herman Mitchell, Augusto A. Litonjua, Geoffrey A. Mueller, George O'connor, Dennis R. Ownby, Wanda Phipatanakul, Victoria Persky, Matthew S. Perzanowski, Clare D. Ramsey, Päivi M. Salo, Julie M. Schwaninger, Joanne E. Sordillo, Avrum Spira, Shakira F. Suglia, Alkis Togias, Darryl C. Zeldin, Elizabeth C. Matsui,
Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of ...
Tópico(s): Climate Change and Health Impacts
2017 - Elsevier BV | Journal of Allergy and Clinical Immunology
Danny Dvir, Israel M. Barbash, Itsik Ben‐Dor, Petros Okubagzi, Lowell F. Satler, Ron Waksman, Augusto D. Pichard,
The penetration rate of devices in general, and in transcatheter aortic valve replacement (TAVR) specifically, is significantly delayed in the United States of America (USA) compared with in Europe. This is mostly due to the mission statement of the regulatory agencies in the USA, which requires very rigorous clinical testing of a device prior to its approval. The USA had a major role in the development and evaluation of this technology and USA research has enabled clinicians inside and outside of ...
Tópico(s): Cardiovascular Function and Risk Factors
2012 - Elsevier BV | Archives of cardiovascular diseases
Itsik Ben‐Dor, Steven A. Goldstein, Ron Waksman, Lowell F. Satler, Yanlin Li, Asmir I. Syed, Gabriel Maluenda, Sara D. Collins, William O. Suddath, Rebecca Torguson, Zhenyi Xue, Kimberly Kaneshige, Petros Okubagzi, Dee Dee Wang, Kenneth M. Kent, Augusto D. Pichard,
The aim of this study was to assess the change in coronary flow in patients who underwent percutaneous aortic valve replacement (PAVR) for severe aortic stenosis. The left main coronary artery was visualized using transesophageal echocardiography in 17 patients who underwent PAVR. The peak systolic and diastolic velocities of coronary flow and the time-velocity integral were obtained before and after PAVR using pulsed-wave Doppler. The median age was 80.0 years (interquartile range [IQR] 80.0 to 88. ...
Tópico(s): Coronary Interventions and Diagnostics
2009 - Elsevier BV | The American Journal of Cardiology
Itsik Ben‐Dor, Patrick Looser, Gabriel Maluenda, Travis C. Weddington, Nicholas G. Kambouris, Israel M. Barbash, Camille Hauville, Petros Okubagzi, Paul J. Corso, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Most transcatheter aortic valve replacement (T-AVR) using the Edwards SAPIEN transcatheter heart valve (Edwards Lifesciences, Irvine, CA) is done under general anesthesia. The present study aimed to examine the feasibility and safety of T-AVR under monitored anesthesia care and aimed to compare the clinical outcome to the outcome of patients who underwent general anesthesia. The analysis included 92 consecutive patients undergoing T-AVR via the transfemoral approach guided by transesophageal echocardiography ...
Tópico(s): Aortic Disease and Treatment Approaches
2012 - Elsevier BV | Cardiovascular revascularization medicine
Sa’ar Minha, Israel M. Barbash, Marco A. Magalhães, Itsik Ben‐Dor, Petros G. Okubagzi, Lakshmana Pendyala, Lowell F. Satler, Augusto D. Pichard, Rebecca Torguson, Ron Waksman,
This study aimed to report the outcomes of African Americans (AAs) in the US undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis (AS).Compared to Caucasians, AAs are reported to have poorer outcomes from most cardiovascular diseases, including high complication rates after surgical aortic valve replacement. The outcomes of AAs undergoing TAVR are not well established.Consecutive patients who underwent TAVR were included in this analysis. Patients' baseline characteristics, ...
Tópico(s): Cardiovascular Function and Risk Factors
2014 - Wiley | Catheterization and Cardiovascular Interventions
Edward Koifman, Sarkis Kiramijyan, Smita Negi, Romain Didier, Ricardo O. Escárcega, Sa’ar Minha, Jiaxing Gai, Rebecca Torguson, Petros Okubagzi, Itsik Ben‐Dor, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Background Conflicting results have been reported regarding impact of body mass index (BMI) on outcome of transcatheter aortic valve replacement (TAVR) patients. This study evaluates the impact of BMI on 1 year mortality in patients undergoing TAVR via the transfemoral (TF) access. Methods Aortic stenosis (AS) patients undergoing TAVR via a TF access between May 2007 and December 2014 were categorized to 4 groups by BMI: low (<20), normal (20–24.9), overweight (25–30), and obese (>30). Baseline parameters ...
Tópico(s): Cardiac Imaging and Diagnostics
2015 - Wiley | Catheterization and Cardiovascular Interventions
Toby Rogers, Arie Steinvil, Jiaxiang Gai, Rebecca Torguson, Edward Koifman, Sarkis Kiramijyan, Smita Negi, Sang Yeub Lee, Petros Okubagzi, Lowell F. Satler, Itsik Ben‐Dor, Augusto D. Pichard, Ron Waksman,
We sought to determine whether balloon-expandable valve (BEV) and self-expanding valve (SEV) affect valve hemodynamics differently according to native aortic annulus size. Transcatheter aortic valve replacement can achieve superior prosthetic valve hemodynamics compared with surgical aortic valve replacement, particularly in patients with small aortic annulus. One hundred ninety-three consecutive transcatheter aortic valve replacement patients were grouped into tertiles defined by computed tomography ...
Tópico(s): Cardiovascular Function and Risk Factors
2016 - Elsevier BV | The American Journal of Cardiology
Sarkis Kiramijyan, Marco A. Magalhães, Itsik Ben‐Dor, Edward Koifman, Ricardo O. Escárcega, Nevin C. Baker, Rebecca Torguson, Petros Okubagzi, Nelson L. Bernardo, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
The objective of this study was to describe and evaluate the adjunctive technique of Angio-Seal (AS) use to augment the dual Perclose ProGlide (PP) in achieving haemostasis in patients undergoing transfemoral percutaneous transcatheter aortic valve replacement (TAVR).All patients who underwent TAVR from May 2007 to January 2015 via a planned transfemoral percutaneous approach with a dual PP pre-close strategy were retrospectively analysed. This cohort was divided into two groups: dual PP versus dual ...
Tópico(s): Infective Endocarditis Diagnosis and Management
2016 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Romain Didier, Edward Koifman, Sarkis Kiramijyan, Smita Negi, Rebecca Torguson, Petros Okubagzi, Augusto D. Pichard, Ron Waksman,
The present study aimed to evaluate the impact of prior cardiovascular events (CVE) on outcome in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR).Patients with severe AS undergoing TAVR between May 2007 and March 2015 were included and categorized to patients with and without prior stroke, defined as embolic, hemorrhagic stroke and transit ischemic attack. Baseline, procedural characteristics, in-hospital outcomes, and 1-month and 1-year mortality ...
Tópico(s): Aortic Disease and Treatment Approaches
2016 - Elsevier BV | Cardiovascular revascularization medicine
Kyle Buchanan, Toby Rogers, M. Chadi Alraies, Arie Steinvil, Edward Koifman, Ricardo O. Escárcega, Arpi Tavil‐Shatelyan, Joelle Salmon, Jiaxiang Gai, Linzhi Xu, Rebecca Torguson, Petros Okubagzi, Augusto D. Pichard, Itsik Ben‐Dor, Lowell F. Satler, Ron Waksman,
Clinical indications for transcatheter aortic valve replacement (TAVR) and elements of the implantation procedure, including delivery system miniaturization and novel access options, have evolved over time. The reasons patients are excluded from TAVR also have changed. The impact of these changes on patient referral for and exclusion from TAVR is unknown. We retrospectively analyzed patients referred to our center for TAVR from January 2010 to August 2016 to evaluate reasons for patient exclusion. ...
Tópico(s): Cardiac Imaging and Diagnostics
2017 - Elsevier BV | American Heart Journal
Itsik Ben‐Dor, Gabriel Maluenda, Danny Dvir, Israel M. Barbash, Petros Okubagzi, Rebecca Torguson, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Objectives : This study aimed to determine success‐ and complication rates after balloon aortic valvuloplasty (BAV) and the outcome of BAV as a standalone therapy versus BAV as a bridge to transcatheter/surgical aortic valve replacement (T/SAVR). Background : The introduction of transcatheter aortic valve replacement (TAVR) has led to a revival in BAV as treatment for patients with severe aortic stenosis. Methods : A cohort of 472 patients underwent 538 BAV procedures. The cohort was divided into two groups: ...
Tópico(s): Aortic Disease and Treatment Approaches
2012 - Wiley | Catheterization and Cardiovascular Interventions
Itsik Ben‐Dor, Sa’ar Minha, Israel M. Barbash, Omar Aly, Danny Dvir, Teshome Deksissa, Petros Okubagzi, Rebecca Torguson, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Brain natriuretic peptide (BNP) is a marker of systolic and diastolic dysfunction and a strong predictor of mortality in heart failure patients. The present study aimed to assess the relationship of BNP with aortic stenosis (AS) severity and prognosis. The cohort comprised 289 high-risk patients with severe AS who were referred for transcatheter aortic valve implantation. Patients were divided into tertiles based on BNP level: I (n = 96); II (n = 95), and III (n = 98). Group III patients were more symptomatic, ...
Tópico(s): Heart Failure Treatment and Management
2013 - Elsevier BV | The American Journal of Cardiology
Itsik Ben‐Dor, Rahul Malik, Sa’ar Minha, Steven A. Goldstein, Dee Dee Wang, Marco A. Magalhães, Gaby Weissman, Petros G. Okubagzi, Rebecca Torguson, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Patients with severe aortic stenosis and no obstructed coronary arteries are reported to have reduced coronary flow. Doppler evaluation of proximal coronary flow is feasible using transesophageal echocardiography. The present study aimed to assess the change in coronary flow in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI). The left main coronary artery was visualized using transesophageal echocardiography in 90 patients undergoing TAVI using the Edwards ...
Tópico(s): Cardiac Imaging and Diagnostics
2014 - Elsevier BV | The American Journal of Cardiology
Johanna Lepeule, Augusto A. Litonjua, Antonio Gasparrini, Petros Koutrakis, David Sparrow, Pantel Vokonas, Joel Schwartz,
While the effects of weather variability on cardio-respiratory mortality are well described, research examining the effects on morbidity, especially for vulnerable populations, is warranted. We investigated the associations between lung function and outdoor temperature (T in Celsius degrees (°C)) and relative humidity (RH), in a cohort of elderly men, the Normative Aging Study. Our study included 1103 participants whose forced vital capacity (FVC), forced expiratory volume in one second (FEV1), and weather ...
Tópico(s): Thermoregulation and physiological responses
2018 - Elsevier BV | Environmental Research
Itsik Ben‐Dor, Gabriel Maluenda, Patrick Looser, Petros Okubagzi, Rebecca Torguson, Zhenyi Xue, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Background: Coronary artery disease often coexists with severe aortic stenosis. The feasibility and safety of combined balloon aortic valvuloplasty (BAV) and percutaneous coronary intervention (PCI) are unknown. Aim: To compare outcomes and complications of combined BAV and PCI with BAV alone. Methods: The study cohort consisted of 409 patients with severe aortic stenosis undergoing BAV from 1/2007 to 12/2010. Overall, 329 patients underwent BAV alone and 80 underwent concomitant PCI. Clinical and ...
Tópico(s): Coronary Interventions and Diagnostics
2011 - Wiley | Catheterization and Cardiovascular Interventions
Itsik Ben‐Dor, Danny Dvir, Israel M. Barbash, Petros Okubagzi, Rebecca Torguson, Zhenyi Xue, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Recent randomized clinical trials have demonstrated that transcatheter aortic valve implantation (TAVI) reduces mortality in high-risk patients with aortic stenosis who are not candidates for aortic valve replacement (AVR). In similar patients who are acceptable candidates for AVR, TAVI provides equivalent outcomes to AVR. In this study, 900 patients with severe aortic stenosis at high surgical risk were evaluated as possible candidates for TAVI. Of these, 595 (66.1%) had neither TAVI nor AVR and constituted ...
Tópico(s): Aortic Disease and Treatment Approaches
2012 - Elsevier BV | The American Journal of Cardiology
Itsik Ben‐Dor, Gabriel Maluenda, Getachew D. Iyasu, Ana Laynez‐Carnicero, Camille Hauville, Rebecca Torguson, Petros Okubagzi, Zhenyi Xue, Steven A. Goldstein, Joseph Lindsay, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
Left ventricular systolic dysfunction in patients with severe aortic stenosis (AS) is associated with poor outcome. This analysis was designed primarily to describe the clinical course of a large series of consecutive patients with severe AS and low ejection fraction (EF) (<40%) who, because of high surgical risk, were referred for transcatheter aortic valve implantation consideration. A cohort of 270 patients with severe AS and low EF ( 40 mm Hg, n = 100 [37%]). Patients with low gradients were younger ( ...
Tópico(s): Cardiovascular Function and Risk Factors
2012 - Elsevier BV | The American Journal of Cardiology
Israel M. Barbash, Danny Dvir, Itsik Ben‐Dor, Salem Badr, Petros Okubagzi, Rebecca Torguson, Paul J. Corso, Zhenyi Xue, Lowell F. Satler, Augusto D. Pichard, Ron Waksman,
The incidence and prognostic implication of myocardial injury after transcatheter aortic valve replacement (TAVR) have not been consistently studied. We aimed to assess the incidence and extent of myocardial injury after TAVR performed using transfemoral and transapical approaches. The clinical data from patients with aortic stenosis who underwent TAVR were retrospectively analyzed. The myocardial necrosis markers cardiac troponin I and creatine kinase (CK)-MB were assessed during hospitalization. ...
Tópico(s): Cardiac Imaging and Diagnostics
2013 - Elsevier BV | The American Journal of Cardiology
Joanne E. Sordillo, Karen M Switkowski, Brent A. Coull, Joel Schwartz, Itai Kloog, Heike Gibson, Augusto A. Litonjua, Jennifer F. Bobb, Petros Koutrakis, Sheryl L. Rifas‐Shiman, Emily Oken, Diane R. Gold,
Abstract Prenatal exposures may be critical for immune system development, with consequences for allergic disease susceptibility. We examined associations of prenatal exposures (nutrient intakes and air pollutants) with allergic disease biomarkers in adolescence. We used data from 857 mother-child pairs in Project Viva, a Massachusetts-based pre-birth cohort. Outcomes of interest at follow-up (median age 12.9 years) were fractional exhaled nitric oxide (FeNO) and total serum IgE. We applied Bayesian ...
Tópico(s): Health, Environment, Cognitive Aging
2018 - Nature Portfolio | Scientific Reports
Johanna Lepeule, Augusto A. Litonjua, Brent A. Coull, Petros Koutrakis, David Sparrow, Pantel Vokonas, Joel Schwartz,
Few studies have been performed on air pollution effects on lung function in the elderly, a vulnerable population with low reserve capacity, and even fewer have looked at changes in the rate of lung function decline.We evaluated the effect of long-term exposure to black carbon on levels and rates of decline in lung function in the elderly.FVC and FEV1 were measured one to six times during the period 1995-2011 in 858 men participating in the Normative Aging Study. Exposure to black carbon, a tracer ...
Tópico(s): Vehicle emissions and performance
2014 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine