Christiane Caneva, Emilie-Charlotte Monnier, Caroline Pulfrey, Laila El‐Hamamsy, Sunny Avry, Jessica Delher Zufferey,
Purpose In digital education curricular initiatives, some teachers are taking on key roles when appointed as instructional coaches (ICs) and become crucial in the sustainability of the initiative by coaching teachers. This study aimed to find out the difficulties ICs are facing when mentoring teachers in the development of the digital skills and to identify the coaching activities the coaches offer. Design/methodology/approach Employing a mixed-methods research design focusing on a qualitative approach, ...
Tópico(s): Child Development and Digital Technology
2023 - Emerald Publishing Limited | International Journal of Mentoring and Coaching in Education
Sunny Avry, Gaëlle Molinari, Mireille Bétrancourt, Guillaume Chanel,
Collaborative problem-solving has been gaining attention as more and more students and employees work together all around the world to find solutions to complex problems. This trend goes hand in hand with a growing interest in the role of affective processes in learning and problem-solving fields. However, the comprehension of real-time dynamics between emotional sharing and collaborative exchanges (what we propose to call "collaborative act") still needs to be deepened. The challenge is especially ...
Tópico(s): Educational Strategies and Epistemologies
2020 - Frontiers Media | Frontiers in Psychology
Sunny Avry, Guillaume Chanel, Mireille Bétrancourt, Gaëlle Molinari,
The role of emotions in (computer-supported) collaborative learning has become an important research topic. However, research has mainly focused on the relationships between emotions and socio-emotional processes. Despite an extensive literature on the role of emotions in cognitive processes, socio-cognitive processes have been scarcely explored at this point. This article aims to investigate, using control-value theory (Pekrun, 2006) as a frame of reference, how task-achievement appraisals impact ...
Tópico(s): Creativity in Education and Neuroscience
2020 - Elsevier BV | Computers in Human Behavior
Ruth Rahamimov, Hagit Tifti-Orbach, Boris Zingerman, Hefziba Green, Shira Schneider, Avry Chagnac, Eytan Mor, Benjamin D. Fox, Benaya Rozen‐Zvi,
Tópico(s): Transplantation: Methods and Outcomes
2019 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Amir Schechter, Anat Gafter‐Gvili, Daniel Shepshelovich, Ruth Rahamimov, Uzi Gafter, Eytan Mor, Avry Chagnac, Benaya Rozen‐Zvi,
Post transplantation anemia (PTA) is common among kidney transplant patients. PTA is associated with increased graft loss and in most studies with increased mortality. However, the effect of the severity of anemia on this associations was not thoroughly evaluated.Patients who underwent kidney transplantation in Rabin Medical Center (RMC) were included in the study. Data were collected during the years 2002-2016. Anemia was defined as hemoglobin (Hb) level less than 12 g/dL in women and less than 13 ...
Tópico(s): Renal Transplantation Outcomes and Treatments
2019 - BioMed Central | BMC Nephrology
Shelly Lichtenberg, Ruth Rahamimov, Hefziba Green, Benjamin D. Fox, Eytan Mor, Uzi Gafter, Avry Chagnac, Benaya Rozen‐Zvi,
Tópico(s): Transplantation: Methods and Outcomes
2017 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Benaya Rozen‐Zvi, Shira Schneider, Shelly Lichtenberg, Hefziba Green, Ori Cohen, Uzi Gafter, Avry Chagnac, Eytan Mor, Ruth Rahamimov,
Background. The variability of tacrolimus blood levels has been shown to be associated with inferior graft survival. However, the effect of variability during the early post-transplantation period has not been evaluated. We sought to evaluate the association between time-weighted variability in the early post-transplantation period and graft survival. We also explored the interaction between drug level variability and exposure to inadequate drug levels. Methods. This retrospective cohort study included ...
Tópico(s): Organ Transplantation Techniques and Outcomes
2016 - Oxford University Press | Nephrology Dialysis Transplantation
Vivette D. D’Agati, Avry Chagnac, Aiko P. J. de Vries, Moshe Levi, Esteban Porrini, Michal Herman‐Edelstein, Manuel Praga,
Tópico(s): Birth, Development, and Health
2016 - Nature Portfolio | Nature Reviews Nephrology
Boris Zingerman, Michal Herman‐Edelstein, A. Erman, Sarit Bar Sheshet Itach, Yaacov Ori, Benaya Rozen‐Zvi, Uzi Gafter, Avry Chagnac,
Aims Obesity is an important risk factor for the development of chronic kidney disease. One of the major factors involved in the pathogenesis of obesity-associated kidney disease is glomerular hyperfiltration. Increasing salt-delivery to the macula densa is expected to decrease glomerular filtration rate (GFR) by activating tubuloglomerular feedback. Acetazolamide, a carbonic anhydrase inhibitor which inhibits salt reabsorption in the proximal tubule, increases distal salt delivery. Its effects on ...
Tópico(s): Renal Diseases and Glomerulopathies
2015 - Public Library of Science | PLoS ONE
Ana Tobar, Yaacov Ori, Sydney Benchetrit, Gai Milo, Michal Herman‐Edelstein, Boris Zingerman, Netta Lev, Uzi Gafter, Avry Chagnac,
Obesity is associated with glomerular hyperfiltration, increased proximal tubular sodium reabsorption, glomerular enlargement and renal hypertrophy. A single experimental study reported an increased glomerular urinary space in obese dogs. Whether proximal tubular volume is increased in obese subjects and whether their glomerular and tubular urinary spaces are enlarged is unknown.To determine whether proximal tubules and glomerular and tubular urinary space are enlarged in obese subjects with proteinuria ...
Tópico(s): Pediatric Urology and Nephrology Studies
2013 - Public Library of Science | PLoS ONE
Darrel H. Higa, Marilyn J. Hoppe, Taryn Lindhorst, Shawn L. Mincer, Blair Beadnell, Diane M. Morrison, Elizabeth A. Wells, Avry Todd, Sarah Mountz,
Factors associated with the well-being of lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ) youth were qualitatively examined to better understand how these factors are experienced from the youths' perspectives. Largely recruited from LGBTQ youth groups, 68 youth participated in focus groups (n = 63) or individual interviews (n = 5). The sample included 50% male, 47% female, and 3% transgender participants. Researchers used a consensual methods approach to identify negative and positive ...
Tópico(s): HIV/AIDS Research and Interventions
2012 - SAGE Publishing | Youth & Society
A. Erman, Ruth Rahamimov, Tiki Mashraki, Rachel S. Levy‐Drummer, János Winkler, Iskra David, Yehudit Hirsh, Uzi Gafter, Avry Chagnac,
Microalbuminuria predicts graft loss and death in the renal transplant population. Measurement of the urinary albumin-to-creatinine ratio (UACR) is recommended for its detection. There is uncertainty regarding the optimal UACR cutoff values. Few studies have examined the accuracy of UACR in the general population and none have been conducted in renal transplant recipients. The aim of this study is to determine the performance of UACR in the renal transplant population.
Tópico(s): Neurological Complications and Syndromes
2011 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Ilya Freidkin, Michal Herman, Ana Tobar, Avry Chagnac, Yaacov Ori, Asher Korzets, Uzi Gafter,
Glomerular mesangial cells (MCs) proliferate and produce extracellular matrix proteins in many progressive renal diseases. Recently, histone deacetylase inhibitors (HDIs) were shown to have antiproliferative and antifibrogenic effects in some in vitro and in vivo models. Using the [(3)H]-thymidine incorporation test, we have found that the HDI trichostatin A (TSA) effectively inhibits MC growth at nontoxic nanomolar concentrations. Similarly, the HDI valproic acid also inhibited MCs proliferation. Cell- ...
Tópico(s): Nuclear Receptors and Signaling
2009 - American Physical Society | AJP Renal Physiology
Avry Chagnac, Michal Herman, Boris Zingerman, A. Erman, Benaya Rozen‐Zvi, Judith Hirsh, Uzi Gafter,
Obesity is associated with hypertension and glomerular hyperfiltration. A major mechanism responsible for the obesity-associated hypertension is renal salt retention. An increased glomerular filtration fraction (FF) is expected to raise postglomerular oncotic pressure and to increase proximal tubular sodium reabsorption. The aim of the present study was to verify whether obesity-associated hyperfiltration leads to increased postglomerular oncotic pressure and increased proximal sodium reabsorption. ...
Tópico(s): Dialysis and Renal Disease Management
2008 - Oxford University Press | Nephrology Dialysis Transplantation
Yaacov Ori, Michal Herman, Uzi Gafter, Avry Chagnac, Asher Korzets, Ana Tobar, Gil Chernin, Ofer Ben Izhak,
Background Acute phosphate nephropathy (APN) is a clinicopathological entity causing renal failure, after ingestion of oral sodium phosphate solution (OSPS). Approximately 25 cases have been described, but OSPS is still widely used. This study reports a further 5 cases and discusses the ever-growing significance of APN. Methods Five cases of APN were included, 3 retrospectively whereas 2 were diagnosed prospectively. In all, use of OSPS was established, and other causes of nephrocalcinosis were excluded. ...
Tópico(s): Chronic Kidney Disease and Diabetes
2008 - Elsevier BV | The American Journal of the Medical Sciences
Sarayut Janmahasatian, Stephen B. Duffull, Avry Chagnac, Carl M. J. Kirkpatrick, Bruce Green,
Descriptors of body size and renal function are the most important covariates in pharmacokinetic studies. Several methods can be used to estimate glomerular filtration rate (GFR) [1], the most common being Cockcroft and Gault [2]. Studies of GFR in the obese population have shown both increases in GFR [3] and no change [4]. Methods based on creatinine (see for an overview [5]) may overestimate GFR due to its active secretion. In contrast, inulin is considered an accurate measure of GFR [6]. We hypothesize ...
Tópico(s): Renal function and acid-base balance
2008 - Wiley | British Journal of Clinical Pharmacology
Yaacov Ori, Reni Sabo, Yuval Binder, Talia Weinstein, Asher Korzets, Gilad Ori, Uzi Gafter, Avry Chagnac,
Determining the dry weight of chronically hemodialysed patients is a common problem. Patients on intermittent hemodialysis often experience transient hoarseness at the end of dialysis. The vocal folds may be affected by the hydration state.To test the hypothesis that postdialysis hoarseness may be related to changes in the thickness of the vocal folds.Twenty-five stable chronic hemodialysis patients underwent endoscopic nasopharyngeal laryngoscopy before and after dialysis. Pictures of the vocal ...
Tópico(s): Respiratory and Cough-Related Research
2006 - Karger Publishers | Nephron Clinical Practice
Yaacov Ori, Avry Chagnac, Ariel Schwartz, Michal Herman, Talia Weinstein, Dina Zevin, Uzi Gafter, Asher Korzets,
Non-occlusive mesenteric ischemia (NOMI) can be a fatal complication in dialysis patients. Intradialytic hypotension is usually the precipitating factor. The occurrence of 16 cases in 5 years (1998-2002), compared with only 4 in previous years, led us to investigate other risk factors contributing to NOMI. A control group of stable hemodialysis patients was used for comparison.20 patients were studied: 17 diagnosed surgically, and 3 clinically. The mean age was 70.8 +/- 1.8 years, and the male:female ...
Tópico(s): Blood Pressure and Hypertension Studies
2005 - Karger Publishers | Nephron Clinical Practice
Talia Weinstein, Avry Chagnac, Mona Boaz, Yaacov Ori, Michal Herman, Dina Zevin, Hemda Schmilovitz‐Weiss, Uzi Gafter,
Hepatitis B (HBV) infection remains a significant epidemiological problem in the end-stage renal disease (ESRD) population. Vaccination programs using second-generation vaccines lead to effective seroprotection in only 50-60% of these patients. The purpose of this case series was to describe our experience with a novel third-generation vaccine, Bio-Hep-B, in ESRD patients who had not developed protective anti-HBs titers following a second-generation HBV vaccination protocol. Twenty-nine ESRD patients ...
Tópico(s): Hepatitis Viruses Studies and Epidemiology
2004 - Karger Publishers | Nephron Clinical Practice
Yona Kalechman, Uzi Gafter, Talia Weinstein, Avry Chagnac, Ilya Freidkin, Ana Tobar, Michael Albeck, Benjamin Sredni,
Mesangial cell (MC) proliferation is essential for the pathogenesis and progression of glomerular disease. Using an acute model of mesangial proliferative glomerulonephritis (Thy1 GN), we show that neutralization of interleukin (IL)-10 greatly ameliorated the disease as expressed by both decreased MC expansion and proteinuria. Treatment with the tellurium compound AS101 (ammonium trichloro(dioxoethylene-o,o')tellurate) resulted in favorable effects provided that the compound was administered 24 h before ...
Tópico(s): Renal Diseases and Glomerulopathies
2004 - Elsevier BV | Journal of Biological Chemistry
A. Weiss, Avry Chagnac, Yichayaou Beloosesky, Talia Weinstein, J Grinblat, Ehud Grossman,
Orthostatic hypotension (OH) is a common finding in the elderly. OH is defined as a fall of at least 20 mmHg in systolic blood pressure (BP) and/or 10 mmHg in diastolic BP upon assuming an upright posture. Some patients exhibit a fall in BP of less than the defined OH upon standing. The aim of this study was to estimate the prevalence of BP changes not defined as OH among elderly in-patients and to assess the relationship between these changes in the morning and the occurrence of OH during the day. ...
Tópico(s): Obstructive Sleep Apnea Research
2004 - Springer Nature | Journal of Human Hypertension
Yichayaou Beloosesky, J Grinblat, Avraham Weiss, Boris Grosman, Uzi Gafter, Avry Chagnac,
Background Oral sodium phosphate is currently used for colon preparation prior to colonoscopy or barium enema. Sodium phosphate induces hyperphosphatemia, hypocalcemia, and hypokalemia. Elderly patients are at an increased risk for phosphate intoxication due to decreased glomerular filtration rate, medication use, and systemic and gastrointestinal diseases. We investigated these electrolyte disorders and their correlation with creatinine clearance, coexistent diseases, medications, and functional status. ...
Tópico(s): Magnesium in Health and Disease
2003 - American Medical Association | Archives of Internal Medicine
Avry Chagnac, T Weinstein, Michal Herman, Judith Hirsh, Uzi Gafter, Yaacov Ori,
ABSTRACT. Severe obesity is associated with increased renal plasma flow (RPF) and glomerular filtration rate (GFR). The aim of the present study was to examine whether weight loss may reverse glomerular dysfunction in obese subjects without overt renal disease. Renal glomerular function was studied in eight subjects with severe obesity (body mass index [BMI] 48.0 ± 2.4) before and after weight loss. Nine healthy subjects served as controls. GFR and RPF were determined by measuring inulin and PAH clearance. ...
Tópico(s): Bariatric Surgery and Outcomes
2003 - American Society of Nephrology | Journal of the American Society of Nephrology
Michal Herman, Yaacov Ori, Avry Chagnac, Talia Weinstein, Asher Korzets, Dina Zevin, T. Malachi, Uzi Gafter,
Abstract Treatment with cyclosporin A (CsA) in kidney-transplant recipients is associated with reduced DNA repair and enhanced cancer incidence. CsA is an inhibitor of the serine/threonine phosphatase calcineurin, also termed PP2B, which is a Ca 2+ /calmodulin-dependent phosphatase. In this study we sought to elucidate the role of calcineurin in DNA repair using CsA and tacrolimus; examine whether UV-induced DNA repair is associated with dephosphorylation; and investigate whether phosphatases other than calcineurin ...
Tópico(s): Cancer-related Molecular Pathways
2002 - Elsevier BV | Journal of Laboratory and Clinical Medicine
Avry Chagnac, Pearl Herskovitz, Yaacov Ori, T Weinstein, Judith Hirsh, Miriam Katz, Uzi Gafter,
Large dialysate volumes are often required to increase solute clearance for peritoneal dialysis patients. The resulting increase in solute clearance might be attributable to an increased plasma-to-dialysate concentration gradient and/or to an increased effective peritoneal surface area. One of the factors affecting the latter is the peritoneal surface area in contact with dialysate (PSA-CD). The aim of this study was to estimate the change in PSA-CD after a 50% increase in the instilled dialysate ...
Tópico(s): Appendicitis Diagnosis and Management
2002 - American Society of Nephrology | Journal of the American Society of Nephrology
Michal Herman, Talia Weinstein, Asher Korzets, Avry Chagnac, Yaacov Ori, Dina Zevin, T. Malachi, Uzi Gafter,
Cancer incidence is enhanced in transplant recipients. Decreased DNA repair ability is associated with increased cancer incidence. Transplanted patients with cancer were found to have reduced DNA repair. We hypothesized that immunosuppressive therapy may impair DNA repair and thus contribute to the increased cancer incidence in transplanted patients. The objectives of this study were (1) to investigate the effect of two immunosuppressive treatment protocols on DNA repair in kidney transplant recipients; ( ...
Tópico(s): Transplantation: Methods and Outcomes
2001 - Elsevier BV | Journal of Laboratory and Clinical Medicine
Talia Weinstein, Avry Chagnac, Asher Korzets, Mona Boaz, Yaacov Ori, Michal Herman, T. Malachi, Uzi Gafter,
Background. Uraemic patients have a decreased ability to withstand oxidative stress. It is postulated that their antioxidant capacity is reduced, yet the mechanism remains unclear. Recently 33 haemodialysis (HD) patients were exposed to chloramine contamination in the water supply. This led to haemolysis in 24 patients, while nine were unaffected. In the former group haemoglobin decreased from 11.7±1.1 to 8.5± 1.4 g/dl (P<0.0001) and returned to 11.4±0.9 g/dl (P<0.0001) following recovery. During haemolysis, ...
Tópico(s): Iron Metabolism and Disorders
2000 - Oxford University Press | Nephrology Dialysis Transplantation
Avry Chagnac, Talia Weinstein, Asher Korzets, Edward Ramadan, Judith Hirsch, Uzi Gafter,
Differential solute clearances were used to characterize glomerular function in 12 nondiabetic subjects with severe obesity (body mass index >38). Nine healthy subjects served as the control group. In the obese group, glomerular filtration rate (GFR) and renal plasma flow (RPF) exceeded the control value by 51 and 31%, respectively. Consequently, filtration fraction increased. The augmented RPF suggested a state of renal vasodilatation involving, mainly or solely, the afferent arteriole. Albumin excretion ...
Tópico(s): Cardiovascular Health and Disease Prevention
2000 - American Physical Society | AJP Renal Physiology
Ziv Ben‐Ari, E. Broida, Y Kittai, Avry Chagnac, R Tur-Kaspa,
OBJECTIVE: The course of hepatitis B virus (HBV) infection after kidney transplantation is aggressive, with a high mortality rate from liver disease mainly in patients who were serum hepatitis B e antigen (HBeAg) or HBV DNA-positive before transplantation. Lamivudine has been shown to be a potent inhibitor of HBV replication. The aim of the study was to examine the efficacy and safety of lamivudine therapy in patients with chronic renal failure and chronic HBV infection. METHODS: The study population ...
Tópico(s): Liver Disease and Transplantation
2000 - Lippincott Williams & Wilkins | The American Journal of Gastroenterology
Asher Korzets, Avry Chagnac, Talia Weinstein, Yaacov Ori, T. Malachi, Uzi Gafter,
Cellular DNA repair systems are induced whenever DNA is damaged. Reactive oxygen species (ROS) are generated, in vivo, in the tissues as a result of regular cellular metabolism or after exposure to oxidizing agents, such as ultraviolet (UV) irradiation. It has been suggested that ROS mediate DNA damage. The objectives of the study were as follows: (1) to investigate whether hydrogen peroxide (H2O2), the commonly occurring cellular ROS, induces DNA repair as a response to the damage it probably causes; ( ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1999 - Elsevier BV | Journal of Laboratory and Clinical Medicine