... Attraction in Western Meadowlarks Get access Maria Klemperer Aweida Maria Klemperer Aweida 7184 Spring Court, Boulder, CO 80303 Search for ...
Tópico(s): Plant and animal studies
1995 - Oxford University Press | Ornithological Applications
Tópico(s): Neonatal Respiratory Health Research
1990 - Springer Science+Business Media | Experimental Brain Research
Ruth Shiloh, Yuval Gilad, Yaara Ber, Miriam Eisenstein, Dina Aweida, Shani Bialik, Shenhav Cohen, Adi Kimchi,
Abstract Autophagy is an intracellular degradation process essential for adaptation to metabolic stress. DAPK2 is a calmodulin-regulated protein kinase, which has been implicated in autophagy regulation, though the mechanism is unclear. Here, we show that the central metabolic sensor, AMPK, phosphorylates DAPK2 at a critical site in the protein structure, between the catalytic and the calmodulin-binding domains. This phosphorylation activates DAPK2 by functionally mimicking calmodulin binding and ...
Tópico(s): Metabolism, Diabetes, and Cancer
2018 - Nature Portfolio | Nature Communications
Dina Aweida, Inga Rudesky, Alexandra Volodin, Eitan Shimko, Shenhav Cohen,
Myofibril breakdown is a fundamental cause of muscle wasting and inevitable sequel of aging and disease. We demonstrated that myofibril loss requires depolymerization of the desmin cytoskeleton, which is activated by phosphorylation. Here, we developed a mass spectrometry–based kinase-trap assay and identified glycogen synthase kinase 3-β (GSK3-β) as responsible for desmin phosphorylation. GSK3-β inhibition in mice prevented desmin phosphorylation and depolymerization and blocked atrophy upon fasting ...
Tópico(s): Cardiomyopathy and Myosin Studies
2018 - Rockefeller University Press | The Journal of Cell Biology
Andriy S. Yatsenko, Mariya M. Kucherenko, Yuanbin Xie, Dina Aweida, Henning Urlaub, Renate Scheibe, Shenhav Cohen, Halyna R. Shcherbata,
Abstract Background Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity and caused by abnormal functioning of the ECM receptor dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be linked directly to mutations in Dg or its regulatory enzymes, implying the involvement of other, not-yet-characterized, Dg-regulating factors. To advance disease diagnostics and develop new treatment strategies, ...
Tópico(s): Cellular Mechanics and Interactions
2020 - BioMed Central | BMC Medicine
Yara Eid Mutlak, Dina Aweida, Alexandra Volodin, Bar Ayalon, Nitsan Dahan, Anna Parnis, Shenhav Cohen,
Abstract Signaling through the insulin receptor governs central physiological functions related to cell growth and metabolism. Here we show by tandem native protein complex purification approach and super-resolution STED microscopy that insulin receptor activity requires association with the fundamental structural module in muscle, the dystrophin glycoprotein complex (DGC), and the desmosomal component plakoglobin (γ-catenin). The integrity of this high-molecular-mass assembly renders skeletal muscle ...
Tópico(s): Exercise and Physiological Responses
2020 - Nature Portfolio | Nature Communications
Protein degradation maintains cellular integrity by regulating virtually all biological processes, whereas impaired proteolysis perturbs protein quality control, and often leads to human disease. Two major proteolytic systems are responsible for protein breakdown in all cells: autophagy, which facilitates the loss of organelles, protein aggregates, and cell surface proteins; and the ubiquitin-proteasome system (UPS), which promotes degradation of mainly soluble proteins. Recent findings indicate ...
Tópico(s): Autophagy in Disease and Therapy
2021 - Multidisciplinary Digital Publishing Institute | Biomolecules
Maintenance of desmin intermediate filaments (IF) is vital for muscle plasticity and function, and their perturbed integrity due to accelerated loss or aggregation causes atrophy and myopathies. Calpain-1-mediated disassembly of ubiquitinated desmin IF is a prerequisite for desmin loss, myofibril breakdown, and atrophy. Because calpain-1 does not harbor a bona fide ubiquitin-binding domain, the precise mechanism for desmin IF disassembly remains unknown. Here, we demonstrate that the AAA-ATPase, ...
Tópico(s): Skin and Cellular Biology Research
2022 - Springer Nature | EMBO Reports
Ola A. El Sayed, Safaa E. Gawish, Gihan. H. Aweida, Enas A. Auda,
Amiodarone AMD (Cordarone) was a benzofuran derivative, used in management of angina and refractory ventricular arrhythmia. Its effect on the thyroid gland structure and function was investigated in this study.
Tópico(s): Cancer Research and Treatment
2007 - Egypts Presidential Specialized Council for Education and Scientific Research | The Egyptian Journal of Hospital Medicine
... Deliveries of Western Meadowlarks Get access Maria Klemperer Aweida Maria Klemperer Aweida 7184 Spring Court, Boulder, CO 80303 Search for ...
Tópico(s): Avian ecology and behavior
1989 - Oxford University Press | Ornithological Applications
Nadav Tropp, Jennifer E. Gilda, Shenhav Cohen,
... 018-0186-6. Crossref | PubMed | ISI | Google Scholar18. Aweida D, Rudesky I, Volodin A, Shimko E, Cohen ...
Tópico(s): Cerebral Palsy and Movement Disorders
2021 - American Physical Society | AJP Cell Physiology
Ola A. El Sayed, Safaa E. Gawish, Gihan. H. Aweida, Enas A. Auda,
Backgrounds: Amiodarone AMD (Cordarone) was a benzofuran derivative, used in management of angina and refractory ventricular arrhythmia. Its effect on the thyroid gland structure and function was investigated in this study. Material and Methods: Fifty adult male albino rats were used and divided into three groups. The first group was consisted of 10 rats which served as control, received distilled water orally (1ml). The second group was consisted of 20 rats used as therapeutic dose treated group, ...
Tópico(s): Vitamin K Research Studies
2007 - Egypts Presidential Specialized Council for Education and Scientific Research | The Egyptian Journal of Hospital Medicine
Mariya M. Kucherenko, Yuanbin Xie, Andriy S. Yatsenko, Dina Aweida, Henning Urlaub, Shenhav Cohen, Halyna R. Shcherbata,
Dystroglycanopathies are a group of inherited disorders characterized by vast clinical and genetic heterogeneity caused by abnormal functioning of the ECM receptor Dystroglycan (Dg). Remarkably, among many cases of diagnosed dystroglycanopathies, only a small fraction can be directly linked to mutations in Dg or its regulatory enzymes, implying the involvement of other, not yet characterized Dg-regulating factors. To identify new players contributing to dystroglycanopathies, we used Drosophila as ...
Tópico(s): Calpain Protease Function and Regulation
2019 - RELX Group (Netherlands) | SSRN Electronic Journal
Mahira Saiyed, Hana Abdallah Hussein Aweida, Banshi Saboo,
Type 1 diabetes (T1D) is an auto-immune condition that requires insulin and diabetes education (DE), along with some permanent changes to daily routine. DE is the heart of diabetes management. As the saying goes, "Give a man a fish and he will not go hungry that day. Teach him how to fish and he will not be hungry for the rest of his life." In the same way, DE will enhance diabetes self-management skills, build confidence, and improve the quality of life. It is important to give the children the opportunity ...
Tópico(s): Diabetes and associated disorders
2024 - Medknow | Journal of Diabetology
Liaquat Ali, Muhammad Imran Sharif, Syed Ghafran Ali Naqvi, Imran Mohammed, Mirza Baig, Kazi Sidratul Muntaha, Ameena Reema Chalil, Hanna Ali, Hana a Aweida, Ambreen Iqrar,
Pulmonary embolism (PE) is a fatal form of venous thromboembolism (VTE), with an overall untreated mortality of up to 30%. Greater than 50% of patients with lower extremity proximal DVT have concurrent PE at presentation. VTE has been seen in up to one-third of patients with COVID-19 infections requiring intensive care unit (ICU) admission. The objective of this study is to determine the correlation between CT pulmonary angiography, pulmonary embolism clot burden, and the Qanadli scoring system with ...
Tópico(s): COVID-19 and healthcare impacts
2023 - Cureus, Inc. | Cureus