Giles Smith, Andrew Robson, Amanda Andrews, Janice Turner, Christina Hardyment, Maggie O'Farrell, Le Mas Candille, Jeff Wall, Andrew Eames, Dr. B. Duncan, Bennett & Teed, Robert Dawson Scott, Richard Whitehead, Rupert Mellor, Kirsty Fergusson, Hilly Janes, Editor, Adam Sherwin Media Reporter, Sumeet Chatter Jee, Jane MacQuitty, Simon Barnes, Peter Lansley, Paul Hoggart, Mark Frary, Geoffrey C. Ward, Gary Stanton, John Lewis Gaddis, Robin Allison Smith, Michael Evans Defence Editor, D. R. Myddelton, Alex Wade, Philip Howard, Hannah Betts, Sonia Brough, Carol Midgley, James Bone, Rachel Campbell-Johnston, David Lynch, Melissa Katsoulis, Clive Davis, Kate Reardon, Elizabeth Judge, Thomas Eidson, Lesley McKenna, Patrick Kidd, Graham Stewart, Will Pavia, Rupert Croft, Sam Marlowe, Amanda Andrews Media Business Correspondent, Larry McMurtry, Robert Sandall, John Bungey, Geoff Brown, Lord Jacobs, Greg Hurst and Andrew Pierce, Joe Joseph, Giles Coren, Davina McCall, Vivienne Parry, Charles Frazier, Dr Copperfield, Noel Falconer, Ben Webster Transport Correspondent, John Clarke, Nicci French, Stewart Tendler Crime Correspondent, Peter Ferstendik, Anabelle Thorpe, Steve Bird, Ruth Gledhill, Debra Craine, Gary Jacob, Jamie Baker, Mark Mazower, Mike Pattenden, Allan Simmons, Joe Morgan, Dr Jane Collins, Tim Reid, Daniel Finkelstein, Jeanette Winterson, Jane Clarke, Paul McKenzie, Nancy Durrent, Clifford Coonan and Jane MacArtney, Candida Crewe, Alan Hamilton, Peter Millar, AT, Andy Stephens, Nick Wyke, Ian Belcher, Rhys Blakely, Tina Gaudoin, Charles Bremner, Richard Johnson, Ian MacKinnon, Tom Andrews, Ben MacHell, John Banville, Keith how, Liz Chong, Jonathan Sacks, Lucy Sweeney, Malika Rodrigues, Tim Teeman, Jonna Pitman, Karen McVeigh, Malcolm Clark, Jeremy Plester, Derwent May, David Charter Andrew Plerce and Greg Hurst, Angela Jameson, Kate Muir, M. Hancox, Paula Hawkins, Cordelia Fine, Andrew Purcell, Isobel Shepherd Smith, David Rowan, Nigel Williamson, Andrew Marr, TV political pundit, Jerome Burne, Oliver Kay, Daniel McGrory, Ed Potton, Amber Cowan, James Hopkins, Stephen Anderton, Sarah Vine, Mark Atherton, Caroline Hendrie and Annabelle Thorpe, Pete Paphides, Sally Baker, Simon de Bruxelles, Colin Strickland, Rob Wright, John Hopkins Golf Correspondent, Geoffrey Dean, Jane Fearnley-Whittingstall, Christina Koning, Magnus Grimond, David Watts, Raymond Keene, Kate Saunders, Matthew Pryor, Rob Yule, Richard Brass, Matt Hughes, Rebecca O'Connor, Gordon Ramsay, Sumeet Chatterjee, Christine Buckley Industrial Editor, Carol Salter, Petra Roach, Simon Handley, Michael Morpurgo, Caroline Merrell, Rick Jones, Chris Campling, Fran Yeoman, Jain Finlayson, Patrick Hosking, Richard Owen, Ross Leckie, Mark Irving, Patrick Hosking Personal Investor, Roger Boyes, Erica Wagner, Alan Walker, Benedict Allen Writer, Nick Hasell, Chloë Bryan-Brown, Lucy Powell, Margaret Reynolds, David Hands Rugby Correspondent, Tony Cascarino, James Collard, Julian Muscat, Kevin Maher, Paul Chesters, Mike Mulvihill, Nicholas Clee, Steve Jelbert, Nigel Kendall, Nick Szczepanik, Xanthippe, Tom Cox, Robert Crampton, Robin Kempster, Renata Rubnikowicz, William Donaldson and Hermione Eyre, Gitta Sereny, Christopher Booker, Julie Burchill, Hayley Westenra, Dominic Maxwell, Gardner Botsford, Matthew Parris, John Stiles, Anjana Ahuja, Anthony Summers, George Caulkin, Amanda Craig, Rebecca Ley, Caitlin Moran, David Davies, Neil Fisher, Peter Riddell, Ben MacIntyre, Tony Dawe, Alison Gibson, Rebecca O'Connor and Magnus Grimond, John Naish, Anne Ashworth Personal Finance Editor, Paul Golby, Nick Frost, Martin Waller, Peter Laneley, Chris Ayres, Michael Horsnell, Mark Henderson, Andrew Sentance Chief Economist, Carl Mortished International Business Editor, David Cameron, Nigel Hawkes Health Editor, James Jackson, Anna Shepard, Darian Leader, Benedict Nightingale, Etta James, Thomas Mann, Dr Thomas Stuttaford, Stephen Dalton, Dr Lewis H. Thomas, Ben Hoyle, Alyson Rudd, Richard Morrison, Tom Chesshyre, James Christopher, Valerie Grove, Adam Sherwin, Alex O'connell, Lucy Broadbent, Alexandra Blair Education Correspondent, T. C. Boyle, Cath Urquhart Travel Editor, Mark McIntyre, Tobias Hill, Will Hide, Jenny Davey, Douglas Kennedy, Peter Klinger, Anniex Proulx, Mono Negra, Patience Wheatcroft, Joe Bolger, Adrian Cartwright, Ian McEwan,
... Stop Press Drug challenge Stewart ruling Demand on Axel Fortis acquisition British Funds Briefing Look ahead Monday ... Buddies Adventure Travel & Sports Show Making waves Malika Rodrigues on Caribbean cruise gripes Times Online Reader Offers ...
2006 - Gale Group | TDA
Produção Nacional
Revisado por pares
Isabel Dinis Ferreira, Axel Martinelli, Louise Rodrigues, Ediclei Lima do Carmo, Virgı́lio E. do Rosário, Marinete Marins Póvoa, Pedro Cravo,
Summary Objective To evaluate the in vitro efficacy of artesunate (ATN) and artemether (ATH) against Plasmodium falciparum isolates from the Brazilian Amazon state of Pará and to search for mutations and/or altered copy numbers in the putative resistance‐associated pfcrt , pfmdr1 and pfATPase6 genes. Methods In vitro efficacy of ATN and ATH was successfully measured in 56 freshly collected P. falciparum isolates, using a conventional WHO microtest with minor modifications. Single nucleotide polymorphisms ( ...
Tópico(s): HIV/AIDS drug development and treatment
2008 - Wiley | Tropical Medicine & International Health
Axel Martinelli, Louise Rodrigues, Pedro Cravo,
Recent studies have proposed curcumin as a potential partner for artemisinin in artemisinin combination therapies to treat malaria infections. The efficacy of curcumin alone and in combination with artemisinin was evaluated on a clone of Plasmodium chabaudi selected for artemisinin resistance in vivo. The addition of piperine as an enhancer of curcumin activity was also tested. Results indicated that curcumin, both alone and in combination with piperine had only a modest antimalarial effect and ...
Tópico(s): Malaria Research and Control
2008 - Elsevier BV | Experimental Parasitology
Katarzyna Modrzynska, Alison M. Creasey, Laurence Loewe, Timothée Cezard, Sofia Trindade Borges, Axel Martinelli, Louise Rodrigues, Pedro Cravo, Mark Blaxter, Richard Carter, Peter Hunt,
Abstract Background Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances. They are required to design better therapies and limit drug resistance. A mutation in the gene ( pfcrt ) encoding a membrane transporter has been identified as a principal determinant of chloroquine resistance ...
Tópico(s): Parasites and Host Interactions
2012 - BioMed Central | BMC Genomics
Produção Nacional
Revisado por pares
Marília Almeida-Trapp, Marco Kai, Axel Mithöfer, Edson Rodrigues‐Filho,
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2014 - Elsevier BV | Phytochemistry
Produção Nacional
Revisado por pares
Gisela Henriques, Axel Martinelli, Louise Rodrigues, Katarzyna Modrzynska, Richard Fawcett, Douglas R. Houston, Sofia Trindade Borges, Umberto D’Alessandro, Halidou Tinto, Corine Karema, Paul Hunt, Pedro Cravo,
The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that artemisinin resistance has already appeared in natural infections. Understanding the mechanisms of resistance would help to prolong the effective lifetime of these drugs. Genetic markers of resistance are therefore ...
Tópico(s): HIV Research and Treatment
2013 - BioMed Central | Malaria Journal
Produção Nacional
Revisado por pares
Hartmut Beurlen, Rainer Thomas, Marcelo R. Rodrigues da Silva, Axel Müller, Dieter Rhede, Dwight Rodrigues Soares,
The increasing strategic importance of Li- and Ta-ores during the last decades due to the strong consumption growth for rechargeable batteries and high temperature and corrosion resistant capacitors reactivated the interest of studies in pegmatite fields around the world, because these rocks supply respectively 25% and 100% of the world consumption in these elements. Research on petrogenetic issues and major and accessory mineral chemistry variations in rare element (REL)-pegmatites of the Borborema ...
Tópico(s): Geochemistry and Geologic Mapping
2014 - Elsevier BV | Journal of South American Earth Sciences
Ailie Cleghorn, Marilyn Merritt, Jared O. Abagi,
... this article:Kaja Jasińska, Yapo Hermann Akpe, Blahoua Axel Debaye Seri, Benjamin Zinszer, Rodrigue Yoffo Agui-Kouadio, Kelsey Mulford, Erin Curran, Mary- ...
Tópico(s): Second Language Learning and Teaching
1989 - University of Chicago Press | Comparative Education Review
Produção Nacional
Revisado por pares
Sofia Trindade Borges, Pedro Cravo, Alison M. Creasey, Richard Fawcett, Katarzyna Modrzynska, Louise Rodrigues, Axel Martinelli, Paul Hunt,
ABSTRACT Multidrug-resistant Plasmodium falciparum malaria parasites pose a threat to effective drug control, even to artemisinin-based combination therapies (ACTs). Here we used linkage group selection and Solexa whole-genome resequencing to investigate the genetic basis of resistance to component drugs of ACTs. Using the rodent malaria parasite P. chabaudi , we analyzed the uncloned progeny of a genetic backcross between the mefloquine-, lumefantrine-, and artemisinin-resistant mutant AS-15MF and ...
Tópico(s): Parasites and Host Interactions
2011 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
David Jochheim, Magda Zadrozny, Hans Theiß, Moritz Baquet, Fatima Maimer-Rodrigues, Axel Bauer, Philipp Lange, Martin Greif, Christian Kupatt, Jörg Hausleiter, Christian Hagl, Steffen Maßberg, Julinda Mehilli,
Aims: Our aim was to assess the incidence of aortic regurgitation (AR) after transcatheter aortic valve implantation (TAVI) with the second (SXT) versus third-generation (S3) balloon-expandable SAPIEN prosthesis in patients with symptomatic aortic stenosis (AS).Methods and results: Of 634 patients undergoing TAVI in our centre from May 2010 to July 2014, 354 were treated with the SXT and 100 with the S3 prosthesis.The primary outcome was the incidence of morethan-mild post-TAVI AR at discharge.Secondary ...
Tópico(s): Cardiac Arrhythmias and Treatments
2015 - European Association of Percutaneous Cardiovascular Interventions | EuroIntervention
Produção Nacional
Revisado por pares
H. Rodenkirchen, Axel Göttlein, Alessandra Rodrigues Kozovits, Rainer Matyssek, Thorsten E. E. Grams,
Tópico(s): Ecology and Vegetation Dynamics Studies
2008 - Springer Science+Business Media | European Journal of Forest Research
Produção Nacional
Revisado por pares
Camille Pinto Figueiredo, David Simón, Matthias Englbrecht, Judith Haschka, Arnd Kleyer, Sara Bayat, Axel J. Hueber, Rosa Maria Rodrigues Pereira, Jürgen Rech, Georg Schett,
To search for evidence of secondary osteoarthritis (OA) in patients with rheumatoid arthritis (RA) in a cross-sectional and longitudinal setting, and to relate osteophyte formation to functional outcome.Anti-citrullinated protein antibody (ACPA)-positive RA patients underwent high-resolution peripheral quantitative computed tomography of the hand. Cross-sectional and longitudinal measurements were performed. The number and size (volume) of osteophytes as well as bone erosions were documented. The relationship ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2016 - Wiley | Arthritis & Rheumatology
Axel Kröner, Sérgio S. Rodrigues,
The feedback stabilization of the Burgers system to a nonstationary solution using finite-dimensional internal controls is considered. Estimates for the dimension of the controller are derived. In the particular case of no constraint on the support of the control, a better estimate is derived and the possibility of getting an analogous estimate for the general case is discussed; some numerical examples are presented illustrating the stabilizing effect of the feedback control and suggesting that ...
Tópico(s): Computational Fluid Dynamics and Aerodynamics
2015 - Society for Industrial and Applied Mathematics | SIAM Journal on Control and Optimization
Produção Nacional
Revisado por pares
Ferry Slik, Janet Franklin, Víctor Arroyo‐Rodríguez, Richard Field, Salomón Aguilar, Nikolay Aguirre, Jorge Ahumada, Shin‐ichiro Aiba, Luciana F. Alves, K. Anitha, Andrés Avella, Francisco Mora, Gerardo A. Aymard C., Selene Báez, Patricia Balvanera, Meredith L. Bastian, Jean‐François Bastin, Peter J. Bellingham, Eduardo van den Berg, Polyanna da Conceição Bispo, Pascal Boeckx, Katrin Boehning‐Gaese, Frans Bongers, Brad Boyle, Fabian Brambach, Francis Q. Brearley, Sandra Brown, Shauna-Lee Chai, Robin L. Chazdon, Shengbin Chen, Phourin Chhang, George B. Chuyong, Corneille Ewango, Indiana Coronado, Jurgi Cristóbal‐Azkarate, Heike Culmsee, Kipiro Damas, H. S. Dattaraja, Priya Davidar, Saara J. DeWalt, Hazimah Din, Donald R. Drake, Álvaro Duque, Giselda Durigan, Karl A. O. Eichhorn, Eduardo Schmidt Eler, Tsutomu Enoki, Andreas Enßlin, Adandé Belarmain Fandohan, Nina Farwig, Kenneth J. Feeley, Markus Fischer, Olle Forshed, Queila Souza Garcia, Satish Chandra Garkoti, Thomas W. Gillespie, Jean‐François Gillet, Christelle Gonmadje, Íñigo Granzow-de la Cerda, Daniel M. Griffith, James Grogan, Khalid Rehman Hakeem, David J. Harris, Rhett D. Harrison, Andy Hector, Andreas Hemp, Jürgen Homeier, Mohammad Shah Hussain, Guillermo Ibarra‐Manríquez, I. Faridah Hanum, Nobuo Imai, Patrick A. Jansen, Carlos Alfredo Joly, Shijo Joseph, Kuswata Kartawinata, Elizabeth Kearsley, Daniel L. Kelly, Michael Kessler, Timothy J. Killeen, Robert M. Kooyman, Yves Laumonier, Susan G. W. Laurance, William F. Laurance, Michael J. Lawes, Susan G. Letcher, Jeremy Lindsell, Jon C. Lovett, José Rafael Lozada, Xinghui Lu, Anne Mette Lykke, Khairil Mahmud, Ni Putu Diana Mahayani, Mashhor Mansor, Andrew R. Marshall, Emanuel H. Martin, Darley C. Leal Matos, Jorge A. Meave, Felipe P. L. Melo, Zhofre Huberto Aguirre Mendoza, Faizah Metali, Vincent P. Medjibe, Jean Paul Metzger, Thiago Metzker, Dharmalingam Mohandass, Miguel A. Munguía‐Rosas, Rodrigo Muñoz, Eddy Nurtjahy, Eddie Lenza de Oliveira, Onrizal Onrizal, Pia Parolin, Marc Parren, N. Parthasarathy, Ekananda Paudel, Rolando Pérez, Eduardo A. Pérez‐García, Ulf Pommer, Lourens Poorter, Lan Qie, María Teresa Fernández Piedade, José Roberto Rodrigues Pinto, Axel Dalberg Poulsen, John R. Poulsen, Jennifer S. Powers, P. Rama Chandra Prasad, Jean‐Philippe Puyravaud, Orlando Rangel, Jan Reitsma, Diogo Souza Bezerra Rocha, Samir Gonçalves Rolim, Francesco Rovero, Andes Hamuraby Rozak, Kalle Ruokolainen, Ervan Rutishauser, Gemma Rutten, Mohd Nizam Mohd Said, Felipe Zamborlini Saiter, Philippe Saner, Bráulio Almeida Santos, João Roberto dos Santos, Swapan Kumar Sarker, Christine B. Schmitt, Jochen Schoengart, Mark Schulze, Douglas Sheil, Plínio Sist, Alexandre F. Souza, Wilson Roberto Spironello, Tereza Cristina Souza Spósito, Robert Steinmetz, Tariq Stévart, Márcio Seiji Suganuma, Rahayu Sukmaria Sukri, Aisha Sultana, Raman Sukumar, Trey Sunderland, Supriyadi Supriyadi, H. S. Suresh, Eizi Suzuki, Marcelo Tabarelli, Jianwei Tang, Ed V. J. Tanner, Natália Targhetta, Ida Theilade, Duncan W. Thomas, Jonathan Timberlake, Márcio de Morisson Valeriano, J.L.C.H. van Valkenburg, Tran Van Do, Hoàng Văn Sâm, John Vandermeer, Hans Verbeeck, Ole R. Vetaas, V. A. J. Adekunle, Simone Aparecida Vieira, Campbell O. Webb, Edward L. Webb, Timothy J. S. Whitfeld, Serge A. Wich, John Williams, Susan K. Wiser, Florian Wittmann, Xiaobo Yang, Constant Yves Adou Yao, Sandra Yap, Rakan A. Zahawi, Rahmad Zakaria, Runguo Zang,
Significance Identifying and explaining regional differences in tropical forest dynamics, structure, diversity, and composition are critical for anticipating region-specific responses to global environmental change. Floristic classifications are of fundamental importance for these efforts. Here we provide a global tropical forest classification that is explicitly based on community evolutionary similarity, resulting in identification of five major tropical forest regions and their relationships: ( ...
Tópico(s): Plant Diversity and Evolution
2018 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Produção Nacional
Revisado por pares
Tobias Pilz, José Miguel Delgado, Sebastian Voß, Klaus Vormoor, Till Francke, Alexandre Cunha Costa, Eduardo Sávio Passos Rodrigues Martins, Axel Bronstert,
Abstract. The semiarid northeast of Brazil is one of the most densely populated dryland regions in the world and recurrently affected by severe droughts. Thus, reliable seasonal forecasts of streamflow and reservoir storage are of high value for water managers. Such forecasts can be generated by applying either hydrological models representing underlying processes or statistical relationships exploiting correlations among meteorological and hydrological variables. This work evaluates and compares ...
Tópico(s): Flood Risk Assessment and Management
2019 - Copernicus Publications | Hydrology and earth system sciences
Difabachew K. Belay, Randy M. Huckaba, Axel O. Ramírez-Madera, J. C. V. Rodrigues, John E. Foster,
A Carlavirus transmitted by Bemisia tabaci (Gennadius), (Hemiptera: Aleyrodidae), is an important disease of soybean nurseries in Puerto Rico causing substantial germplasm loses. Insecticide bioassay experiments were conducted at Dow AgroSciences (DAS) Research Station, Santa Isabel, Puerto Rico, either by spraying insecticides on B. tabaci infested soybean leaves or introducing B. tabaci adults onto insecticide sprayed soybean leaves. Moreover, host plants were surveyed to detect the virus in overwintering ...
Tópico(s): Plant Virus Research Studies
2012 - Elsevier BV | Crop Protection
Kaja Kinga Jasińska, Hermann AKPE, Blahoua Axel Debaye Seri, Benjamin D. Zinszer, Rodrigue Yoffo Agui-Kouadio, Kelsey Mulford, Erin Curran, Mary‐Claire Ball, Fabrice Tanoh,
Abstract Few standardized language assessments are adapted to different cultural and linguistic contexts to assess children’s first language (L1) abilities. We introduce the Ivorian Children’s Language Assessment Toolkit for measuring phonological awareness, vocabulary, oral comprehension, and tone awareness in the Abidji, Attié, and Baoulé languages of Côte d’Ivoire. Six hundred and three primary-school children (age 4–14) completed language assessments in their L1 and French. The toolkit provided ...
Tópico(s): Multilingual Education and Policy
2022 - Oxford University Press | Applied Linguistics
Produção Nacional
Revisado por pares
Gezimar D. de Souza, Axel Mithöfer, Cristina Daolio, Bernd Schneider, Edson Rodrigues‐Filho,
This present work describes the application of liquid chromatography-solid phase extraction-nuclear magnetic resonance spectroscopy to analyse Alternaria alternata crude extracts. Altenusin (1), alternariol (2), 3'-hydroxyalternariol monomethyl ether (3), and alternariol monomethyl ether (4), were separated and identified. High-resolution mass spectrometry confirmed the proposed structures. The cytotoxic effects of these compounds towards plants were determined using soybean (Glycine max) cell cultures ...
Tópico(s): Plant Pathogens and Fungal Diseases
2013 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Vivian B. Neis, Morgana Moretti, Priscila B. Rosa, Yasmim de Oliveira Dalsenter, Isabel Werle, Nicolle Platt, Fernanda Neutzling Kaufmann, Axel Fogaça Rosado, Matheus Henrique Besen, Ana Lúcia S. Rodrigues,
AZD6765 (lanicemine) is a non-competitive NMDA receptor antagonist that induces a fast-acting antidepressant effect without presenting psychotomimetic effects. However, the mechanisms underlying its effects remain to be established. In this context, we demonstrated that a single administration of AZD6765 (1 mg/kg, i.p.) was able to induce an antidepressant-like effect in mice submitted to tail suspension test (TST), an effect reversed by LY294002 (a reversible PI3K inhibitor, 10 nmol/site, i.c.v.), ...
Tópico(s): Tryptophan and brain disorders
2020 - Elsevier BV | Pharmacology Biochemistry and Behavior
Tatiana Brémovà-Ertl, Clara Sztatecsny, Matthias Brendel, M. Moser, Bettina Möller, Dirk‐André Clevert, Stefanie Beck‐Wödl, Célia Kun‐Rodrigues, José Brás, Axel Rominger, Dimitar Ninov, Michael Strupp, Susanne A. Schneider,
To characterize subclinical abnormalities in asymptomatic heterozygote NPC1 mutation carriers as markers of neurodegeneration.Motor function, cognition, mood, sleep, and smell function were assessed in 20 first-degree heterozygous relatives of patients with Niemann-Pick disease type C (NPC) (13 male, age 52.7 ± 9.9 years). Video-oculography and abdominal ultrasound with volumetry were performed to assess oculomotor function and size of liver and spleen. NPC biomarkers in blood were analyzed. 18F-fluorodesoxyglucose ...
Tópico(s): Cerebral Palsy and Movement Disorders
2020 - Lippincott Williams & Wilkins | Neurology
Produção Nacional
Revisado por pares
Camille Pinto Figueiredo, Arnd Kleyer, David Simón, Fabian Stemmler, Isabelle d’Oliveira, Anja Weißenfels, Oleg Museyko, Andreas Friedberger, Axel J. Hueber, Judith Haschka, Matthias Englbrecht, Rosa Maria Rodrigues Pereira, Jürgen Rech, Georg Schett, Klaus Engelke,
The comparison between different techniques to quantify the 3-dimensional size of inflammatory bone erosions in rheumatoid arthritis(RA) patients. Anti-cyclic citrullinated peptide antibody(ACPA) positive RA patients received high-resolution peripheral quantitative computed tomography (HR-pQCT) scans of the metacarpophalangeal joints (MCP). Erosions were measured by three different segmentation techniques: (1) manual method with calculation by half-ellipsoid formula, (2) semi-automated modified Evaluation ...
Tópico(s): Orthopedic Infections and Treatments
2017 - Elsevier BV | Seminars in Arthritis and Rheumatism
Produção Nacional
Revisado por pares
MarÃlia Almeida Trapp, Gezimar D. de Souza, Edson Rodrigues‐Filho, William Boland, Axel Mithöfer,
Phytohormones are long time known as important components of signaling cascades in plant development and plant responses to various abiotic and biotic challenges. Quantifications of phytohormone levels in plants are typically carried out using GC or LC-MS/MS systems, due to their high sensitivity, specificity, and the fact that not much sample preparation is needed. However, mass spectrometer-based analyses are often affected by the particular sample type (different matrices), extraction procedure, ...
Tópico(s): Allelopathy and phytotoxic interactions
2014 - Frontiers Media | Frontiers in Plant Science
Isabelle C. Van Gelder, Michiel Rienstra, Karina V Bunting, Rubén Casado-Arroyo, Valeria Caso, Harry J.G.M. Crijns, Tom De Potter, Jeremy Dwight, Luigina Guasti, Thorsten Hanke, Tiny Jaarsma, Maddalena Lettino, Maja‐Lisa Løchen, R. Thomas Lumbers, Bart Maesen, Inge Mølgaard, Giuseppe Rosano, Prashanthan Sanders, Renate B. Schnabel, Piotr Suwalski, Emma Svennberg, Juan Tamargo, Otilia Țica, Vassil Traykov, Stylianos Tzeis, Dipak Kotecha, Nikolaos Dagres, Bianca Rocca, Syed Ahsan, Pietro Ameri, Elena Arbelo, Axel Bauer, Michael A. Borger, Sergio Buccheri, Barbara Casadei, Ovidiu Chioncel, Dobromir Dobrev, Laurent Fauchier, Bruna Gigante, Michael Glikson, Ziad Hijazi, Gerhard Hindricks, Daniela Husser, Borja Ibáñez, Stefan James, Stefan Kääb, Paulus Kirchhof, Lars Køber, Konstantinos C. Koskinas, Thomas Kümler, Gregory Y H Lip, John Mandrola, Nikolaus Marx, John William Mcevoy, Borislava Mihaylova, Richard Mindham, Denisa Muraru, Lis Neubeck, Jens Cosedis Nielsen, Jonas Oldgren, Maurizio Paciaroni, Agnès Pasquet, Eva Prescott, Filip Rega, Francisco Javier Rossello, Marcin Ruciński, Sacha P. Salzberg, Sam Schulman, Philipp Sommer, Jesper Hastrup Svendsen, Jurriën M. ten Berg, Hugo Ten Cate, Ilonca Vaartjes, Christiaan Vrints, Adam Witkowski, Katja Zeppenfeld, Leonard Simoni, B. Kichou, Hamayak Sisakian, Douglas S. Scherr, Frank Cools, Elnur Smajić, Tchavdar Shalganov, Šime Manola, Panayiotis Avraamides, Miloš Táborský, Axel Brandes, Ahmed M El-Damaty, Priit Kampus, Pekka Raatikainen, Rodrigue Garcia, Kakhaber Etsadashvili, Lars Eckardt, Eleftherios M. Kallergis, László Gellér, Kristján Guðmundsson, Jonathan Lyne, Ibrahim Marai, Furio Colivicchi, Ayan Abdrakhmanov, Ibadete Bytyçi, Alina Kerimkulova, Kaspars Kupics, Marwan M. Refaat, Osama Bheleel, Jūratė Barysienė, Patrick Leitz, Mark Sammut, Aurel Grosu, Nikola Pavlović, Abdelhamid Moustaghfir, Sing‐Chien Yap, Jane Taleski, Trine Fink, Jarosław Kaźmierczak, Víctor Sanfins, Dragoș Cozma, Marco Zavatta, Dragan Kovačević, Peter Hlivák, Igor Zupan, David de Gonzalo‐Calvo, Anna Björkenheim, Michael Kühne, Sana Ouali, Sabri Demircan, Oleg S Sychov, G. André Ng, Husniddin Kuchkarov,
ESC.
Tópico(s): Cardiac, Anesthesia and Surgical Outcomes
2024 - Oxford University Press | European Heart Journal
Siddhant Patki, Julian Aquilina, Rebecca Jayne Thorne, Isaac Aristidou, Filipe B. Rodrigues, Hannah Warren, Axel Bex, Veeru Kasivisvanathan, Caroline M. Moore, Kurinchi Selvan Gurusamy, Mark Emberton, Lawrence MJ Best, Maxine Tran,
Prostate cancer (PC) disproportionately affects men of Black race, and lower educational and socioeconomic status. Guidelines are based on randomised controlled trials (RCTs); however, the representation of different races, educations, and socioeconomic backgrounds in these trials is unclear.To assess reporting of equality, diversity, and inclusion characteristics (Equality, Diversity and Inclusion [EDI]) and differences in treatment effects between different races, and educational or socioeconomic ...
Tópico(s): Global Cancer Incidence and Screening
2023 - Elsevier BV | European Urology Open Science
Peter Hunt, Axel Martinelli, Katarzyna Modrzynska, Sofia Trindade Borges, Alison M. Creasey, Louise Rodrigues, Dario Beraldi, Laurence Loewe, Richard Fawcett, Sujai Kumar, Marian Thomson, Urmi Trivedi, Thomas D. Otto, Arnab Pain, Mark Blaxter, Pedro Cravo,
Classical and quantitative linkage analyses of genetic crosses have traditionally been used to map genes of interest, such as those conferring chloroquine or quinine resistance in malaria parasites. Next-generation sequencing technologies now present the possibility of determining genome-wide genetic variation at single base-pair resolution. Here, we combine in vivo experimental evolution, a rapid genetic strategy and whole genome re-sequencing to identify the precise genetic basis of artemisinin ...
Tópico(s): Parasites and Host Interactions
2010 - BioMed Central | BMC Genomics
Leonor R. Rodrigues, Martyna K. Zwoinska, R. Axel W. Wiberg, Rhonda R. Snook,
Abstract Increasing temperature and thermal variability generate profound selection on populations. Given the fast rate of environmental change, understanding the role of plasticity and genetic adaptation in response to increasing temperatures is critical. This may be especially true for thermal effects on reproductive traits in which thermal fertility limits at high temperatures may be lower than for survival traits. Consequences of changing environments during development on adult phenotypes may ...
Tópico(s): Insect and Arachnid Ecology and Behavior
2022 - Wiley | Journal of Animal Ecology
Produção Nacional
Revisado por pares
Arnt Erik Tjønna, Joyce S. Ramos, Axel Preßler, Martin Halle, Klaus Jungbluth, Erika Ermacora, Øyvind Salvesen, Jhennyfer Aline Lima Rodrigues, Carlos Roberto Bueno Júnior, Peter Scott Munk, Jeff S. Coombes, Ulrik Wisløff,
Metabolic syndrome substantially increases risk of cardiovascular events. It is therefore imperative to develop or optimize ways to prevent or attenuate this condition. Exercise training has been long recognized as a corner-stone therapy for reducing individual cardiovascular risk factors constituting the metabolic syndrome. However, the optimal exercise dose and its feasibility in a real world setting has yet to be established. The primary objective of this randomized trial is to investigate the ...
Tópico(s): Cardiovascular Function and Risk Factors
2018 - BioMed Central | BMC Public Health
Toulsie Ramtohul, Axel Cohen, Manuel Rodrigues, Sophie Piperno‐Neumann, Luc Cabel, Nathalie Cassoux, Livia Lumbroso‐Le Rouic, Denis Malaise, Sophie Gardrat, Gaëlle Pierron, Pascale Mariani, Vincent Servois,
The RECIST-based response variably matches the clinical benefit of systemic therapies for liver metastatic uveal melanoma (LMUM). The aims were to determine whether the tumour growth rate (TGR) can help predict the survival in patients with LMUM and to provide information for the management of first-line systemic treatment.This retrospective study included 147 (training: n = 110, validation: n = 37) patients with LMUM treated with first-line systemic treatment between 2010 and 2021. Two TGR-derived parameters ...
Tópico(s): Cutaneous Melanoma Detection and Management
2022 - Springer Nature | British Journal of Cancer
Produção Nacional
Revisado por pares
Alessandra Rodrigues Kozovits, Rainer Matyssek, H. Blaschke, Axel Göttlein, Thorsten E. E. Grams,
Abstract Saplings of Fagus sylvatica and Picea abies were grown in mono‐ and mixed cultures in a 2‐year phytotron study under all four combinations of ambient and elevated ozone (O 3 ) and carbon dioxide (CO 2 ) concentrations. The hypotheses tested were (1) that the competitiveness of beech rather than spruce is negatively affected by the exposure to enhanced O 3 concentrations, (2) spruce benefits from the increase of resource availability (elevated CO 2 ) in the mixed culture and (3) that the responsiveness ...
Tópico(s): Atmospheric chemistry and aerosols
2005 - Wiley | Global Change Biology
Produção Nacional
Revisado por pares
Anderson Camargo, Ana Paula Dalmagro, Nicolle Platt, Axel Fogaça Rosado, Vivian B. Neis, Ana Lúcia Bertarello Zeni, Manuella P. Kaster, Ana Lúcia S. Rodrigues,
Several attempts have been made to understand the role of cholecalciferol (vitamin D3) in the modulation of neuropsychiatric disorders. Notably, the deficiency of vitamin D3 is considered a pandemic and has been postulated to enhance the risk of major depressive disorder (MDD). Therefore, this study aims to investigate the antidepressant-like effect of cholecalciferol in a mouse model of depression induced by corticosterone, and the possible role of glucocorticoid receptors (GR), NLRP3 and autophagic ...
Tópico(s): Vitamin D Research Studies
2020 - Elsevier BV | Pharmacology Biochemistry and Behavior