Tatsuya Uezu, Aya Hirano, Masato Okada,
We examine a previouly introduced attractor neural network model that explains the persistent activities of neurons in the anterior ventral temporal cortex of the brain. In this model, the coexistence of several attractors including correlated attractors was reported in the cases of finite and infinite loading. In this paper, by means of a statistical mechanical method, we study the statics and dynamics of the model in both finite and extensive loading, mainly focusing on the retrieval properties ...
Tópico(s): Neural Networks Stability and Synchronization
2004 - Physical Society of Japan | Journal of the Physical Society of Japan
Kenji Yano, Koichiro Aya, Ko Hirano, Reynante Lacsamana Ordonio, Miyako Ueguchi‐Tanaka, Makoto Matsuoka,
Abstract Current gibberellin (GA) research indicates that GA must be perceived in plant nuclei by its cognate receptor, GIBBERELLIN INSENSITIVE DWARF1 (GID1). Recognition of GA by GID1 relieves the repression mediated by the DELLA protein, a model known as the GID1-DELLA GA perception system. There have been reports of potential GA-binding proteins in the plasma membrane that perceive GA and induce α-amylase expression in cereal aleurone cells, which is mechanistically different from the GID1-DELLA ...
Tópico(s): Plant Virus Research Studies
2014 - Oxford University Press | PLANT PHYSIOLOGY
Junmu Tanaka, Kenji Yano, Koichiro Aya, Ko Hirano, Sayaka Takehara, Eriko Koketsu, Reynante Lacsamana Ordonio, Seunghyun Park, Masatoshi Nakajima, Miyako Ueguchi‐Tanaka, Makoto Matsuoka,
Sex determination driven by community cooperation An optimized ratio of male and females in a sexually reproducing population helps to generate the genetic diversity useful to a species in a changing world. Tanaka et al. studied a fern in which the sex ratio is adjusted not by individual identity, but by signaling between individual plants (see the Perspective by Sun). Early-maturing individual ferns express some of the biosynthetic genes needed to make a precursor of the plant hormone gibberellin, ...
Tópico(s): Plant Parasitism and Resistance
2014 - American Association for the Advancement of Science | Science
Narae Choi, Toshio Yamanaka, Akihisa Takemura, Tomohiro Kobayashi, Aya Eto, Masato Hirano,
Indoor environment has an appreciable impact on occupants' mood, health and performance. Among numerous indoor environmental components, indoor air quality is often considered to be one of the most crucial ones. While odor is a decisive factor for evaluating perceived indoor air quality, its effects - particularly the positive effects of pleasant aromas - on human responses and performance have yet to be revealed. In this study, experiments were conducted to investigate the effect of indoor aroma on ...
Tópico(s): Advanced Chemical Sensor Technologies
2022 - Elsevier BV | Building and Environment
Tomohiro Yokozeki, Aya Sugiura, Yoshiyasu Hirano,
This paper describes the development and the wind tunnel test of a variable geometry morphing airfoil using corrugated structures. Proof-of-concept study of a morphing wing with corrugated flexible seamless flap-like structure is verified by finite element analysis, and a prototype is manufactured using carbon fiber reinforced plastics. For the actuation system, two servomotors are installed inside the prototype wing to control the airfoil shape by the chordwise tension of the connected wires. Successful ...
Tópico(s): Aerodynamics and Fluid Dynamics Research
2014 - American Institute of Aeronautics and Astronautics | Journal of Aircraft
Naoko Mato, Masashi Bando, Aya Kusano, Toshikatsu Hirano, Masayuki Nakayama, Tomohiro Uto, Takakiyo Nakaya, Hideaki Yamasawa, Yukihiko Sugiyama,
Interleukin 33 (IL-33) works as a functional mediator in allergic disease by enhancing the activity of eosinophils and inducing expression of T helper 2 (Th2)-associated cytokines. However, the role of IL-33 in pulmonary eosinophilia has not been elucidated. We investigated the levels of IL-33 in eosinophilic pneumonia (EP) together with associated cytokines, and discussed the clinical significance of IL-33 in EP.Sera and bronchoalveolar lavage fluid (BALF) were obtained from 16 patients with EP, including ...
Tópico(s): Eosinophilic Esophagitis
2013 - Elsevier BV | Allergology International
Kozo Motonaga, Masayuki Itoh, Aya Hirayama, Satoru Hirano, Laurence E. Becker, Yu‐ichi Goto, Sachio Takashima,
We studied the expression of the apoptosis-related protein, E2F-1, in Down's syndrome (DS) brains. The immunoreactivity for E2F-1 was detected in the pyramidal neurons of the cerebral cortex from DS brains exhibiting the neuropathological features of dementia of Alzheimer type (DAT), in accordance with the amyloid beta protein (A beta) deposition in the neuron. Therefore, the implication is that A beta deposition may trigger E2F-1-mediated neuronal apoptosis in DS brains with DAT.
Tópico(s): Cancer-related Molecular Pathways
2001 - Elsevier BV | Brain Research
Akon Higuchi, Aya Komuro, Kyosuke Hirano, Boo Ok Yoon, Mariko Hara, Tomoko Hirasaki, Yuri Nishimoto, Masanobu Yokogi, Sei‐ichi Manabe,
Permeation of γ-globulin solution through three microfiltration membranes (Planova 35N (mean pore size (r)=0.035 μm), Nucleopore (r=0.1 μm) and Fluoropore (r=0.1 μm)) was investigated. A drastic increase in flux was found with a decrease in DNA in the feed solution, which was normally contained in the protein solution as a contamination in the order of ppb. A DNA–γ-globulin complex having a particle size of 135–225 nm was detected by dynamic light scattering measurements in the γ-globulin solution. The ...
Tópico(s): Membrane-based Ion Separation Techniques
2001 - Elsevier BV | Journal of Membrane Science
Tsuyoshi Inukai, Aya Sako, Hiroyuki Hirano, Yoshio Sano,
In plant genomes as well as other eukaryotic genomes, meiotic recombination does not occur uniformly. At the level of the gene, high recombination frequencies are often observed within genetic loci in maize, but this feature of intragenic recombination is not seen at the csr1 locus in Arabidopsis. These observations suggest that meiotic recombination in plant genomes varies considerably among species. In the present study we investigated meiotic recombination at the wx locus in rice. The mutation ...
Tópico(s): Chromosomal and Genetic Variations
2000 - NRC Research Press | Genome
Yasunori Utsunomiya, K Omura, Takashi Yokoo, Toshiyuki Imasawa, Tetsuya Kawamura, Aya Abe, Keita Hirano, Tetsuya Mitarai, Naoki Maruyama, Osamu Sakai,
In this study, we examined the effects of macrophage-colony stimulating factor (M-CSF) on glomerular macrophages in lipopolysaccharide (LPS)-induced murine nephritis. Mice injected intraperitoneally with either M-CSF plus LPS, LPS alone, M-CSF alone or saline every day for 8 days were examined for the degree of urine albumin excretion and lymphocyte-function associated antigen-1-positive (LFA-1+) cells in peripheral blood as well as renal pathology. From our results, LPS or M-CSF combined with LPS ...
Tópico(s): Reproductive System and Pregnancy
1996 - Oxford University Press | Clinical & Experimental Immunology
... org/10.1007/s00438-005-0013-8Tsuyoshi Inukai, Aya Sako, Hiro-Yuki Hirano, Yoshio Sano Analysis of intragenic recombination at wx ...
Tópico(s): Silicon Effects in Agriculture
1957 - University of Chicago Press | The American Naturalist
Tsuyoshi Inukai, Aya Sako, Hiroyuki Hirano, Yoshio Sano,
Tópico(s): Genetic Mapping and Diversity in Plants and Animals
2000 - NRC Research Press | Genome
Daisaku Hirano, Aya Mashiko, Yasutaka Murata, Katsuhiko Satoh, Taketo Ichinose, Satoru Takahashi, Toyoharu Jike, Masahiko Sugitani,
Tópico(s): Urologic and reproductive health conditions
2009 - Springer Science+Business Media | Medical Molecular Morphology
Shinya Fujii, Ryota Sekine, Atsushi Kano, Hiroyuki Masuno, Chalermkiat Songkram, Emiko Kawachi, Tomoya Hirano, Aya Tanatani, Hiroyuki Kagechika,
Non-secosteroidal vitamin D receptor (VDR) ligands are promising candidates for many clinical applications. We recently developed novel non-secosteroidal VDR agonists based on p-carborane (an icosahedral carbon-containing boron cluster) as a hydrophobic core structure. Here, we report the design, synthesis and biological evaluation of carborane-based vitamin D analogs bearing various substituents at the diol moiety. Among the synthesized compounds, methylene derivative 31 exhibited the most potent ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2014 - Elsevier BV | Bioorganic & Medicinal Chemistry
Shinya Fujii, Atsushi Kano, Hiroyuki Masuno, Chalermkiat Songkram, Emiko Kawachi, Tomoya Hirano, Aya Tanatani, Hiroyuki Kagechika,
Vitamin D receptor (VDR), a nuclear receptor for 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3, 1), is a promising target for multiple clinical applications. We recently developed non-secosteroidal VDR ligands based on a carbon-containing boron cluster, 1,12-dicarba-closo-dodecaborane (p-carborane), and examined the binding of one of them to VDR by means of crystallographic analysis. Here, we utilized that X-ray structure to design novel p-carborane-based tetraol-type vitamin D analogs, and we examined the ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2014 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Shinya Fujii, Atsushi Kano, Chalermkiat Songkram, Hiroyuki Masuno, Yoshiyuki Taoda, Emiko Kawachi, Tomoya Hirano, Aya Tanatani, Hiroyuki Kagechika,
1α,25-Dihydroxyvitamin D3 [1α,25(OH)₂D₃: 1] is a specific modulator of nuclear vitamin D receptor (VDR), and novel vitamin D analogs are therapeutic candidates for multiple clinical applications. We recently developed non-secosteroidal VDR agonists bearing a p-carborane cage (a carbon-containing boron cluster) as a hydrophobic core structure. These carborane derivatives are structurally quite different from classical secosteroidal vitamin D analogs. Here, we report systematic synthesis and activity ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2014 - Elsevier BV | Bioorganic & Medicinal Chemistry
Makito Hirano, Aya Yamamoto, Toshio Mori, Li Lan, Takaaki Iwamoto, Masashi Aoki, Keiji Shimada, Yoshiko Furiya, Shingo Kariya, Hirohide Asai, Akira Yasui, Tomohisa Nishiwaki, Kyoko Imoto, Nobuhiko Kobayashi, Takao Kiriyama, Tetsuya Nagata, Noboru Konishi, Yasuto Itoyama, Satoshi Ueno,
Abstract Objective Early‐onset ataxia with ocular motor apraxia and hypoalbuminemia (EAOH)/ataxia with oculomotor apraxia type 1 (AOA1) is an autosomal recessive form of cerebellar ataxia. The causative protein for EAOH/AOA1, aprataxin (APTX), interacts with X‐ray repair cross‐complementing 1 (XRCC1), a scaffold DNA repair protein for single‐strand breaks (SSBs). The goal of this study was to prove the functional involvement of APTX in SSB repair (SSBR). Methods We visualized the SSBR process with a recently ...
Tópico(s): Mitochondrial Function and Pathology
2007 - Wiley | Annals of Neurology
Chikako Yamada, Hidehiko Izumi, Junko Hirano, Aya Mizukuchi, Mitsuo Kise, Tsukasa Matsuda, Yasuko Kato,
The effect of germination and subsequent heat-processing on the degradation of soluble proteins, including some allergenic proteins, in brown rice grains was investigated. The content of soluble proteins, including 14–16-kDa and 26-kDa allergens, in the germinated and processed brown rice grains (GPR) was much lower than that of non-germinated brown rice. These proteins in brown rice grains were also much lower after subsequent heat-processing during the manufacturing process. The protease activity ...
Tópico(s): Food Allergy and Anaphylaxis Research
2005 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Yusaku Mori, Hiroyuki Shimizu, Hideki Kushima, Munenori Hiromura, Michishige Terasaki, Michitaka Tanaka, Aya Osaki, Tsutomu Hirano,
Tópico(s): Neuropeptides and Animal Physiology
2017 - Springer Nature | Hypertension Research
Natsumi Tomita, Yuji Hotta, Aya Naiki‐Ito, K. Hirano, Tomoya Kataoka, Yasuhiro Maeda, Satoru Takahashi, Kazunori Kimura,
Phosphodiesterase 5 inhibitors are widely used to treat erectile dysfunction and lower urinary tract symptoms with benign prostatic hyperplasia. Recent studies have indicated the renoprotective effects of this class of compounds. Whether renoprotection depends on blood pressure reduction remains controversial. In this study, we investigated the renoprotective effects of the phosphodiesterase 5 inhibitor, tadalafil, in a rat model of high-salt induced kidney injury with hypertension. Dahl salt-sensitive ...
Tópico(s): Hormonal and reproductive studies
2020 - Wiley | Physiological Reports
Katsura Kojima, Aya Hirano, Shin-ichiro Asano, Ken Sahara, Hisanori Bando,
Tópico(s): Cytomegalovirus and herpesvirus research
2001 - Japanese Society of Sericultural Science | Nihon sanshigaku zasshi
Toru Takahashi, Yukio Furuichi, Takafumi Mizuno, Masako Kato, Aya Tabara, Yuka Kawada, Yoshiyuki Hirano, Kin‐ya Kubo, Minoru Onozuka, Osamu Kurita,
Abstract BACKGROUND: The relationships between possible physiological properties of insoluble fibre and the viscosity of digesta are poorly understood. The aim of this study was to investigate the effect of insoluble fibres with different water‐holding capacity, swelling, oil‐holding capacity and cation exchange capacity on gastric, small intestinal and caecal contents in rats fed a semi‐purified diet containing either no fibre (control), 50 g kg −1 tossa jute fibre or 50 g kg −1 shiitake fibre. RESULTS: ...
Tópico(s): Agriculture Sustainability and Environmental Impact
2008 - Wiley | Journal of the Science of Food and Agriculture
Ko Hirano, Koichiro Aya, Tokunori Hobo, Hitoshi Sakakibara, Mikiko Kojima, Rosalyn B. Angeles‐Shim, Yasuko Hasegawa, Miyako Ueguchi‐Tanaka, Makoto Matsuoka,
To investigate the involvement of phytohormones during rice microspore/pollen (MS/POL) development, endogenous levels of IAA, gibberellins (GAs), cytokinins (CKs) and abscisic acid (ABA) in the mature anther were analyzed. We also analyzed the global expression profiles of genes related to seven phytohormones, namely auxin, GAs, CKs, brassinosteroids, ethylene, ABA and jasmonic acids, in MS/POL and tapetum (TAP) using a 44K microarray combined with a laser microdissection technique (LM-array analysis). ...
Tópico(s): Photosynthetic Processes and Mechanisms
2008 - Oxford University Press | Plant and Cell Physiology
Aya Kawasaki, Keita Yamashita, Fumio Hirano, Ken‐ei Sada, Daisuke Tsukui, Yuya Kondo, Yoshitaka Kimura, Kurumi Asako, S Kobayashi, Hidehiro Yamada, Hiroshi Furukawa, Kenji Nagasaka, Takahiko Sugihara, Kunihiro Yamagata, Takayuki Sumida, Shigeto Tohma, Hajime Kono, Shoichi Ozaki, Seiichi Matsuo, Hiroshi Hashimoto, Hirofumi Makino, Yoshihiro Arimura, Masayoshi Harigai, Naoyuki Tsuchiya,
Tópico(s): Inflammasome and immune disorders
2017 - Springer Nature | Journal of Human Genetics
Ko Hirano, Koichiro Aya, Yoichi Morinaka, Shiro Nagamatsu, Yutaka Sato, Baltazar A. Antonio, Nobukazu Namiki, Yoshiaki Nagamura, Makoto Matsuoka,
The plant secondary cell wall is the major source of lignocellulosic biomass, a renewable energy resource that can be used for bioethanol production. To comprehensively identify transcription factors (TFs), glycosyltransferase (GT) and glycosyl hydrolase (GH) involved in secondary cell wall formation in rice (Oryza sativa), co-expression network analysis was performed using 68 microarray data points for different rice tissues and stages. In addition to rice genes encoding orthologs of Arabidopsis thaliana ...
Tópico(s): Biofuel production and bioconversion
2013 - Oxford University Press | Plant and Cell Physiology
Ko Hirano, Koichiro Aya, Mari Kondo, Ayako Okuno, Yoichi Morinaka, Makoto Matsuoka,
Tópico(s): Biofuel production and bioconversion
2011 - Springer Science+Business Media | Plant Cell Reports
Masaki Murase, Aya Tobo, Hideya Onodera, Y. Hirano, Tadaaki Hosaka, Susumu Shimomura, Nobuyoshi Wakabayashi,
Anomalous temperature dependence of electrical resistivity was found to be ubiquitous among the compounds RNiC 2 with R = La, Ce, Nd, Sm, Gd, Tb and Er. Lattice parameters were also observed to exhibit anomalous temperature dependence for some of the compounds studied by X-ray diffraction. It is argued that the existence of charge modulated structures is the cause of the former anomalies. The latter anomalies, on the other hand, are likely to be related to the coupling between the lattice and the ...
Tópico(s): Iron-based superconductors research
2004 - Physical Society of Japan | Journal of the Physical Society of Japan
Mitsue Kurita-Taniguchi, Aya Fukui, Kaoru Hazeki, Akiko Hirano, Shoutaro Tsuji, Misako Matsumoto, Michiko Watanabe, Shigeharu Ueda, Tsukasa Seya,
Abstract Human CD46, formerly membrane cofactor protein, binds and inactivates complement C3b and serves as a receptor for measles virus (MV), thereby protecting cells from homologous complement and sustaining systemic measles infection. Suppression of cell-mediated immunity, including down-regulation of IL-12 production, has been reported on macrophages (Mφ) by cross-linking their CD46. The intracellular events responsible for these immune responses, however, remain unknown. In this study, we found ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2000 - American Association of Immunologists | The Journal of Immunology
Yasunori Utsunomiya, Tetsuya Kawamura, Aya Abe, Hiroko Imai, Keita Hirano, Naoki Maruyama, Tatsuo Hosoya, Osamu Sakai,
To determine whether phenotypic modulation of mesangial and interstitial cells correlated with the long-term prognosis of IgA nephropathy (IgAN), we analyzed retrospectively 27 patients with IgAN whose creatinine clearance at the time of renal biopsy was normal. The patients were subdivided into two groups according to the course of renal function during follow-up. Thirteen patients maintained normal renal function for more than 15 years (stable group), and 14 progressed to end-stage renal disease ( ...
Tópico(s): Platelet Disorders and Treatments
1999 - Elsevier BV | American Journal of Kidney Diseases
Takashi Fujiwara, Kasumi Ohira, Ko Urushibara, Akihiro Ito, Minoru Yoshida, Misae Kanai, Aya Tanatani, Hiroyuki Kagechika, Tomoya Hirano,
Tópico(s): Genomics and Chromatin Dynamics
2016 - Elsevier BV | Bioorganic & Medicinal Chemistry