Soichiro Adachi, Yohei Kirino, Kana Higashitani, Lisa Hirahara, Ayaka Maeda, Nobuyuki Horita, Kaoru Takase-Minegishi, Ryusuke Yoshimi, Hideaki Nakajima,
To unravel the mechanisms underlying cell death in the vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome using peripheral blood samples and to assess the clinical value of this knowledge.
Tópico(s): Vascular Anomalies and Treatments
2024 - Oxford University Press | Rheumatology Advances in Practice
Tomomi Okada, M. K. Savage, Shin’ichi Sakai, Keisuke Yoshida, Naoki Uchida, Ryota Takagi, Shuutoku Kimura, Satoshi Hirahara, Ayaka Tagami, Ryotaro Fujimura, Toru Matsuzawa, Eiji Kurashimo, Yoshihiro Hiramatsu,
Abstract Seismic activity in the Noto region of Ishikawa Prefecture, central Japan, has increased since August 2020 and has continued as of August 2023. Stress changes due to subsurface sources and increases in fluid pressure have been discussed as the causes of the seismic activity increase. In this study, S-wave polarization anisotropy was investigated by S-wave splitting analysis using temporary and permanent stations located in the epicenter area. We also investigated the seismic wave velocity ...
Tópico(s): Seismic Waves and Analysis
2024 - Springer Nature | Earth Planets and Space
Kazuaki Imai, Hisamori Kato, Kayoko Katayama, Kazuho Nakanishi, Aiko Kawano, Ayaka Iura, Katsuyuki Konnai, Ryo Onose, Fumiki Hirahara, Etsuko Miyagi,
Abstract Objective This study aimed to validate the preoperative scoring system adopted in the Kanagawa Cancer Center (KCC) to stratify endometrial cancer patients for lymphadenectomy according to the risk of developing lymph node metastasis (LNM). Methods The records of 432 and 221 uterine cancer patients treated in the KCC and Yokohama City University (YCU), respectively, were retrospectively analyzed. The KCC classified patients for LNM risk based on tumor volume, myometrial invasion, histological grade, ...
Tópico(s): Cervical Cancer and HPV Research
2016 - Elsevier BV | Gynecologic Oncology
Yuhya Hirahara, Midori Yamaguchi, Kaoru Takase‐Minegishi, Yohei Kirino, Shigeru Aoki, Lisa Hirahara, Soichiro Obata, Michi Kasai, Ayaka Maeda, Naomi Tsuchida, Ryusuke Yoshimi, Nobuyuki Horita, Hideaki Nakajima, Etsuko Miyagi,
Abstract Objective The relationship between FMF and pregnancy outcomes remains unclear. This systematic review and meta-analysis aimed to clarify this association. Methods Electronic databases—PubMed, Web of Science, Cochrane, and EMBASE—were searched on 20 December 2022, using specific search terms. Case–control, cohort, and randomized clinical trial studies comparing patients with FMF and healthy controls were considered eligible. We excluded systematic reviews, meta-analyses, case series with ...
Tópico(s): Pregnancy and preeclampsia studies
2023 - Oxford University Press | Lara D. Veeken
Takahiro Aoki, Mariko Takami, Tomozumi Takatani, Kiwamu Motoyoshi, Ayana Ishii, Ayaka Hara, Takahide Toyoda, Reona Okada, Moeko Hino, Ryo Koyama‐Nasu, Masahiro Kiuchi, Kiyoshi Hirahara, Motoko Y. Kimura, Toshinori Nakayama, Naoki Shimojo, Shinichiro Motohashi,
Invariant natural killer T (iNKT) cells are innate-like CD1d-restricted T cells that express the invariant T cell receptor (TCR) composed of Vα24 and Vβ11 in humans. iNKT cells specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d-positive tumor cells, especially when CD1d presents glycolipid antigens. However, iNKT cell recognition of CD1d-negative tumor cells is unknown, and direct cytotoxicity of iNKT ...
Tópico(s): T-cell and B-cell Immunology
2020 - Wiley | Cancer Science
Chiharu Hidekawa, Ryusuke Yoshimi, Yusuke Saigusa, Jun Tamura, Noriko Kojitani, Naoki Suzuki, Natsuki Sakurai, Yuji Yoshioka, Yumiko Sugiyama-Kawahara, Yosuke Kunishita, Daiga Kishimoto, Kana Higashitani, Yuichiro Sato, Takaaki Komiya, Hideto Nagai, Naoki Hamada, Ayaka Maeda, Naomi Tsuchida, Lisa Hirahara, Yutaro Soejima, Kaoru Takase‐Minegishi, Yohei Kirino, Nobuyuki Yajima, Ken‐ei Sada, Yoshia Miyawaki, Kunihiro Ichinose, Shigeru Ohno, Hiroshi Kajiyama, Shuzo Sato, Yasuhiro Shimojima, Michio Fujiwara, Hideaki Nakajima,
Infection is a leading cause of death in patients with systemic lupus erythematosus (SLE). Alt hough hydroxychloroquine (HCQ) has been reported to inhibit infection, evidence from Asian populations remains insufficient. We investigated this effect in Japanese SLE patients.Data from the Lupus Registry of Nationwide Institutions were used in this study. The patients were ≥20 years old and met the American College of Rheumatology (ACR) classification criteria revised in 1997. We defined "severe infections" ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2023 - Frontiers Media | Frontiers in Immunology
Tomomi Okada, Miu Matsuno, Satoshi Matsumoto, Yuta Kawamura, Yoshihisa Iio, Tadashi Sato, Ayaka Tagami, Satoshi Hirahara, Shuutoku Kimura, Stephen Bannister, John Ristau, M. K. Savage, C. H. Thurber, Richard H. Sibson,
The M 7.8 Kaikoura earthquake occurred in the northern South Island of New Zealand on 3 Nov., 2016, involving the rupture of >20 faults. To understand the complexity of the Kaikoura earthquake, details of the fault geometry, seismic velocity distribution, and stress field are necessary. We have undertaken seismic tomography along the c. 200 km length of the rupture zone. Data from both 51 temporary stations and 22 permanent (GeoNet) stations were collected from March 2011 to December 2018. The hypocenter ...
Tópico(s): High-pressure geophysics and materials
2024 - Elsevier BV | Physics of The Earth and Planetary Interiors
Kento Ichikawa, Soichiro Adachi, Kaoru Takase‐Minegishi, Yuta Nakayama, Yutaka Nagasawa, Yuki Iizuka, Ayaka Maeda, Lisa Hirahara, Yutaro Soejima, Takuma Ohashi, Hiroyoshi Kunimoto, Nobuyuki Horita, Ryusuke Yoshimi, Yohei Kirino, Hideaki Nakajima,
Tópico(s): Otitis Media and Relapsing Polychondritis
2024 - Springer Vienna | Clinical and Experimental Rheumatology
Miu Matsuno, Ayaka Tagami, Tomomi Okada, Satoshi Matsumoto, Yuta Kawamura, Yoshihisa Iio, Tadashi Sato, Takashi Nakayama, Satoshi Hirahara, Stephen Bannister, John Ristau, M. K. Savage, C. H. Thurber, Richard H. Sibson,
To understand the stress controls on the occurrence of a multi-fault rupture, we estimated the crustal stress between April 2013 to December 2018, i.e., before and after the Mw7.8 Kaikōura earthquake that occurred in New Zealand on 13 November 2016. We used both the focal mechanism solutions from the temporary seismic networks and the GeoNet moment tensor solutions and selected the solutions that differed significantly from the mainshock fault planes and rakes. Then, we performed stress tensor inversions ...
Tópico(s): Earthquake Detection and Analysis
2022 - Elsevier BV | Tectonophysics
Takahiro Aoki, Mariko Takami, Tomozumi Takatani, Kiwamu Motoyoshi, Ayana Ishii, Ayaka Hara, Takahide Toyoda, Reona Okada, Moeko Hino, Ryo Koyama‐Nasu, Masahiro Kiuchi, Kiyoshi Hirahara, Toshinori Nakayama, Naoki Shimojo, Shinichiro Motohashi,
Background: Invariant natural killer T (iNKT) cells are known as CD1d-restricted T cells that express the invariant T-cell receptors (TCR) Vα24 and Vβ11 in humans and specifically recognize glycolipid antigens such as α-galactosylceramide (αGalCer) presented by CD1d. iNKT cells show direct cytotoxicity toward CD1d-positive tumor cells presenting glycolipid antigens and indirect cytotoxicity by activating other cytotoxic immune cells or regulating CD1d-positive immunosuppressive cells in the tumor microenvironment. ...
Tópico(s): Synthesis and Biological Evaluation
2019 - Elsevier BV | Blood
Fukuko Horio, Tokunori Ikeda, Yanosuke Kouzaki, Tomoo Hirahara, Kengo Masa, Sawana Narita, Yusuke Tomita, Shu Tsuruzoe, Akihiko Fujisawa, Yuki Akinaga, Yoko Ashizuka, Yuki Inoue, Ayaka Unten, Katsutoshi Okamura, Yuiko Takechi, Yasuhiro Takenouchi, Fuka Tanaka, Chiharu Masuda, Yusuke Sugimura, Yuji Uchida,
Abstract Although the scope of pharmacists’ work has expanded in Japan, people’s perception of this is unclear. To contribute to medical care together with non- and health care professionals, clarifying the perceptions of these groups is important to best utilize pharmacist professionals. We conducted a cross-sectional questionnaire survey among non-health care professionals (n = 487) and nurses (n = 151), medical doctors (n = 133), and pharmacists (n = 204) regarding the work of pharmacists. The questionnaire ...
Tópico(s): Patient Satisfaction in Healthcare
2023 - Nature Portfolio | Scientific Reports
Ayaka Tagami, Miu Matsuno, Tomomi Okada, Shin’ichi Sakai, Mako Ohzono, Kei Katsumata, Masahiro Kosuga, Yoshiko Yamanaka, Hiroshi Katao, Takeshi Matsushima, Hiroshi Yakiwara, Satoshi Hirahara, Toshio Kono, Shuichiro HORI, Toru Matsuzawa, Shuutoku Kimura, Takashi Nakayama,
Abstract Inversion tectonics, in which old normal faults act as reverse faults in current stress fields, are frequently observed in northeastern Japan (Tohoku District); however, the conditions that control these fault activities remain unclear. To improve the identification of faults that are more favorable to slip under current stress conditions, the regional fault mechanisms in the Tohoku District must be better understood. The stress field in the Tohoku District and the likelihood of fault activities ...
Tópico(s): High-pressure geophysics and materials
2024 - Springer Nature | Earth Planets and Space