Álvaro Romero-Calvo, Antonio J. García-Salcedo, F. Garrone, I. Rivoalen, Filippo Maggi,
... Thorben Könemann, and UNOOSA’s point of contact Ayami Kojima for their endless support. We would like to ...
Tópico(s): Astro and Planetary Science
2022 - American Institute of Aeronautics and Astronautics | AIAA Journal
Hiro Takahashi, Ayami Nakagawa, Shoko Kojima, Anna Takahashi, Byung‐Yoon Cha, Je‐Tae Woo, Kazuo Nagai, Yasunori Machida, Chiyoko Machida,
The G-quadruplex is one of the most frequently studied secondary DNA structures and consists of 4 guanine residues that interact through Watson–Crick and Hoogsteen pairing. The G-quadruplex formation is thought to be a molecular switch for gene expression. Genome-wide analyses of G-quadruplexes have been published for many species; however, only one genome-wide analysis of G-quadruplexes in plants has been reported. Here, we propose a new approach involving a two-step procedure for identifying G- ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - Elsevier BV | Journal of Bioscience and Bioengineering
Nobuhiko Nishio, Hiroshi Yagasaki, Yoshiyuki Takahashi, Hideki Muramatsu, Asahito Hama, Makito Tanaka, Nao Yoshida, Nobuyuki Watanabe, Kazuko Kudo, Ayami Yoshimi, Seiji Kojima,
Late-onset non-infectious pulmonary complications (LONIPCs) that arise beyond 3 months after allogeneic hematopoietic SCT include bronchiolitis obliterans (BO), bronchiolitis obliterans with organizing pneumonia (BOOP) and idiopathic pneumonia syndrome (IPS). We retrospectively analyzed the incidence and outcome of LONIPCs among pediatric hematopoietic SCT recipients. We included 97 patients who survived for more than 3 months among the 114 who underwent allogeneic hematopoietic SCT between April 1997 ...
Tópico(s): Transplantation: Methods and Outcomes
2009 - Springer Nature | Bone Marrow Transplantation
Ayami Yoshimi, Seiji Kojima, Naoto Hirano,
Tópico(s): Protein Tyrosine Phosphatases
2009 - Adis, Springer Healthcare | Pediatric Drugs
Ayami Yoshimi, Seiji Kojima, Shuichi Taniguchi, Junichi Hara, Toshimitsu Matsui, Yoshiyuki Takahashi, Hiroshi Azuma, Koji Kato, Tokiko Nagamura‐Inoue, Shunro Kai, Shunichi Kato,
In the present study we evaluated the feasibility of unrelated cord blood transplantation (UCBT) in patients with severe aplastic anemia (SAA). The outcome of 31 SAA patients (median age 28; range: 0.9-72.3 years old) who received UCBT was analyzed. The cumulative incidences of the neutrophil and platelet recovery after UCBT were 54.8 and 72.2%, respectively (95% confidence interval [CI] = 36.0%-70.3% and 51.3%-85.3%, respectively). The cumulative incidences of grade ≥II acute and chronic graft-versus-host ...
Tópico(s): Polyomavirus and related diseases
2008 - Elsevier BV | Biology of Blood and Marrow Transplantation
Chiyoko Machida, Ayami Nakagawa, Shoko Kojima, Hiro Takahashi, Yasunori Machida,
Leaf primordia are born around meristem‐containing stem cells at shoot apices, grow along three axes (proximal–distal, adaxial–abaxial, medial–lateral), and develop into flat symmetric leaves with adaxial–abaxial polarity. Axis development and polarity specification of Arabidopsis leaves require a network of genes for transcription factor‐like proteins and small RNAs. Here, we summarize present understandings of adaxial‐specific genes, ASYMMETRIC LEAVES1 ( AS1 ) and AS2 . Their complex (AS1–AS2) functions ...
Tópico(s): Plant Gene Expression Analysis
2015 - Wiley | Wiley Interdisciplinary Reviews Developmental Biology
Takami Akagi, Nagura Mayuka, Ayami Hiura, Hajime Kojima, Mitsuru Akashi,
In vitro generated human skin equivalents are generating interest as promising tools in basic study, as alternatives to animal testing, and for clinical applications in regenerative medicine. For prediction of skin irritation and corrosion, three-dimensional human skin equivalents consisting of differentiated human keratinocytes (KCs) have been developed and some models have been internationally accepted. However, more delicate assessments using full-thickness skin models, such as skin sensitization ...
Tópico(s): Advancements in Transdermal Drug Delivery
2017 - Mary Ann Liebert, Inc. | Tissue Engineering Part A
Yuko Honda, Masahiro Tsuchida, Yuji Zaike, Atsuko Masunaga, Ayami Yoshimi, Seiji Kojima, Masafumi Ito, Akira Kikuchi, Tatsutoshi Nakahata, Atsushi Manabe,
Summary Juvenile myelomonocytic leukaemia ( JMML ) is a rare haematopoietic stem cell disease of early childhood, which can progress to blast crisis in some children. A total of 153 children diagnosed with JMML were reported to the Myelodysplastic Syndrome Committee in Japan between 1989 and 2007; 15 of them (9·8%) had 20% or more blasts in the bone marrow (blast crisis) during the disease course. Blast crisis occurred during observation without therapy ( n = 3) or with oral 6‐mercaptopurine treatment ( n = 9) ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2014 - Wiley | British Journal of Haematology
Ayami Kojima, Daniel García Yárnoz, Simonetta Di Pippo,
In the context of UNISPACE+50, which will mark the 50th anniversary of the first UNISPACE conference held in Vienna in 1968, the United Nations Office for Outer Space Affairs (UNOOSA) has defined four pillars to address the future of space activities and their role in development: space economy, space society, space accessibility and space diplomacy. Under the space accessibility pillar, UNOOSA intends to enable all communities, particularly in developing countries, to use and benefit from space ...
Tópico(s): Space Satellite Systems and Control
2018 - Elsevier BV | Acta Astronautica
Hideki Muramatsu, Seiji Kojima, Ayami Yoshimi, Yoshiko Atsuta, Koji Kato, Yoshihisa Nagatoshi, Masami Inoue, Kazutoshi Koike, Takakazu Kawase, Masaki Ito, Hidemitsu Kurosawa, Akihiko Tanizawa, Chikako Tono, Kazuko Hamamoto, Noriko Hotta, Akihiro Watanabe, Yasuo Morishima, Keisei Kawa, Hiroyuki Shimada,
Because of a small number of patients, only a few studies have addressed the outcome of bone marrow transplantation (BMT) in children with Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML), who receive graft from a volunteer-unrelated donor (VUD), especially after practical application of imatinib mesylate. The outcomes of BMT from a VUD in 125 children with Ph+ CML were retrospectively reviewed. Patients were identified through the Japan Marrow Donor Program as having undergone ...
Tópico(s): Eosinophilic Disorders and Syndromes
2009 - Elsevier BV | Biology of Blood and Marrow Transplantation
It is obvious that Space Education is very important for sustainable space development as children are going to lead the new era of space development. The Japan Aerospace Exploration Agency (thereafter called "JAXA") believes that all children hold 3 spirits which are "Curiosity", "Adventure" and "Craftsmanship". We have been trying to ignite children's spirits toward nature, life and the universe with the effective use of space subjects and materials since the establishment of the JAXA Space Education ...
Tópico(s): Space exploration and regulation
2016 - Elsevier BV | Acta Astronautica
Daisuke Hasegawa, Xiaojuan Chen, Shinsuke Hirabayashi, Yasushi Ishida, Shizuka Watanabe, Yuji Zaike, Masahiro Tsuchida, Atsuko Masunaga, Ayami Yoshimi, Asahito Hama, Seiji Kojima, Masafumi Ito, Tatsutoshi Nakahata, Atsushi Manabe,
This study analysed 65 children who were prospectively registered between 1999 and 2008 and fulfilled the World Health Organization 2008 criteria of refractory cytopenia of childhood (RCC). First-line therapy was determined by the treating physicians: 25 patients received immunosuppressive therapy (IST), 12 patients received haematopoietic stem cell transplantation (HSCT) and one patient received intensive chemotherapy. The remaining 27 patients were followed without treatment for more than 2 years ( ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2014 - Wiley | British Journal of Haematology
Ayami Nakagawa, Hiro Takahashi, Shoko Kojima, Nobuo Sato, Kazuomi Ohga, Byung Yoon, Je‐Tae Woo, Kazuo Nagai, Gorou Horiguchi, Hirokazu Tsukaya, Yasunori Machida, Chiyoko Machida,
Leaves develop as flat lateral organs from the indeterminate shoot apical meristem. The establishment of polarity along three-dimensional axes, proximal–distal, medial–lateral, and adaxial–abaxial axes, is crucial for the growth of normal leaves. The mutations of ASYMMETRIC LEAVES1 (AS1) and AS2 of Arabidopsis thaliana cause defects in repression of the indeterminate state and the establishment of axis formation in leaves. Although many mutations have been identified that enhance the adaxial–abaxial ...
Tópico(s): Plant Reproductive Biology
2012 - Springer Science+Business Media | Plant Molecular Biology
Daniel García Yárnoz, Ayami Kojima, Simonetta Di Pippo,
The United Nations Office for Outer Space Affairs has developed a comprehensive set of capacity-building activities and associated partnerships providing access to experimental facilities on ground and to a wide range of Low Earth Orbit platforms. These opportunities are available to applicants from high-school to university level, as well as other research, governmental and inter-governmental institutions. This is a unique approach to space capacity-building, away from the traditional classroom ...
Tópico(s): Space Exploration and Technology
2018 - Elsevier BV | Acta Astronautica
Takahito Moriyama, N Amamiya, Ayami Ochi, Yuki Tsuruta, Ari Shimizu, Chiari Kojima, Mitsuyo Itabashi, Takashi Takei, Keiko Uchida, Kosaku Nitta,
Tópico(s): Ion Transport and Channel Regulation
2011 - Springer Science+Business Media | Clinical and Experimental Nephrology
Nobuhiro Nishio, Hiroshi Yagasaki, Yoshiyuki Takahashi, Asahito Hama, Hideki Muramatsu, Makito Tanaka, Nao Yoshida, Ayami Yoshimi, Kazuko Kudo, Masafumi Ito, Seiji Kojima,
ES is a complication that occurs immediately before or at the timing of neutrophil engraftment following autologous or allogeneic SCT. It is characterized by fever, skin rash, and non-cardiac pulmonary infiltrates. We evaluated the incidence, risk factors, and outcomes of ES following allogeneic SCT in children. Of 100 pediatric patients, 20 (20%) developed ES occurring at a median of 14 days (range 8-27 days) post-transplant. Patients presented with fever (100%), skin rash (100%), diffuse pulmonary ...
Tópico(s): Neutropenia and Cancer Infections
2008 - Wiley | Pediatric Transplantation
Shunsuke Imanishi, Makiko Nakakita, Kouji Yamashita, Ayami Furuta, Kaname UTSUNO, Nobuhiko Muramoto, Hisae Kojima, Kenzo Nakamura,
Similar to the prostanoid-mediated inflammatory response in mammals, jasmonate-mediated wound response in plant leaves is inhibited by salicylic acid (SA) or acetylsalicylate (aspirin). In tobacco BY-2 cells, expression of the gene for ornithine decarboxylase (ODC) involved in putrescine synthesis is rapidly inducible by methyl jasmonate (MeJA). A nuclear gene for ODC isolated from tobacco, gNtODC-1, was an intron-less gene and MeJA induced the expression of a GUS fusion gene with the gNtODC-1 promoter ...
Tópico(s): Insect and Pesticide Research
2000 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Ayami Yoshimi, Masahumi Ito, Seiji Kojima,
We studied the cytotoxic effects of antithymocyte globulin (ATG) in leukemic cells obtained from five patients with acute T lymphoblastic leukemia or precursor T lymphoblastic leukemia. ATG by itself killed leukemic cells in a dose-dependent manner. Simultaneous incubation with human AB or baby rabbit serum resulted in increased cytolysis of leukemic cells. These results suggested the presence of both direct and complement-mediated cytolysis. We also examined apoptotic cell death using Annexin-V. ...
Tópico(s): RNA Interference and Gene Delivery
2005 - Elsevier BV | Leukemia Research
Toan Quy Luong, Sumie Keta, Toshiharu Asai, Shoko Kojima, Ayami Nakagawa, José Luis Micol, Shitou Xia, Yasunori Machida, Chiyoko Machida,
Balanced development of adaxial and abaxial domains in leaf primordia is critical for the formation of flat symmetric leaf lamina. Arabidopsis ASYMMETRIC LEAVES1 (AS1) and AS2 proteins form a complex (AS1-AS2), which acts as key regulators for the adaxial development by the direct repression of expression of the abaxial gene ETTIN/AUXIN RESPONSE FACTOR3 (ETT/ARF3). Many modifier mutations have been identified, which enhance the defect of as1 and as2 mutations to generate abaxialized filamentous leaves ...
Tópico(s): Plant nutrient uptake and metabolism
2018 - Japanese Society for Plant Biotechnology | Plant Biotechnology
Seiji Kojima, Jun Inaba, Ayami Yoshimi, Yoshiyuki Takahashi, Nobuhiro Watanabe, Kazuko Kudo, Keizo Horibe, Naoko Maeda, Koji Kato, Takaharu Matsuyama,
We report a favourable outcome in 15 patients with severe aplastic anaemia (SAA) who were < 20 years of age and who underwent bone marrow transplantation (BMT) from a human leucocyte antigen (HLA)‐matched unrelated donor. All patients were non‐responders to intensive immunosuppressive therapy (IST) and were multiply transfused. The conditioning regimen consisted of cyclophosphamide (60 mg/kg/d, on d −4 and −3), anti‐thymocyte globulin (2·5 mg/kg/d, on d −5 to −2) and total body irradiation (2·5 Gy × 2/d, on d − ...
Tópico(s): T-cell and B-cell Immunology
2001 - Wiley | British Journal of Haematology
Tomonori Akasaka, Seiji Hokimoto, Daisuke Sueta, Noriaki Tabata, Kenji Sakamoto, Eiichiro Yamamoto, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Yasuhiro Ogata, Hisao Ogawa,
Categorization as a cytochrome P-450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. It is correlated with an increase in the circulating levels of high-sense C-reactive protein (hs-CRP) in women only, although its role in coronary microcirculation is unclear. We examined sex differences in the impact of the CYP2C19 genotype and low-grade inflammation on coronary microvascular disorder (CMVD). We examined CYP2C19 genotypes in patients with CMVD ( ...
Tópico(s): Blood Pressure and Hypertension Studies
2016 - American Physical Society | AJP Heart and Circulatory Physiology
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Seiji Hokimoto,
Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the impact of CYP2C19 polymorphisms and EETs on the patients with microvascular angina (MVA) caused by coronary microvascular dysfunction. We examined CYP2C19 genotypes in patients with ...
Tópico(s): Alcohol Consumption and Health Effects
2017 - Elsevier BV | IJC Heart & Vasculature
Tomonori Akasaka, Daisuke Sueta, Yuichiro Arima, Noriaki Tabata, Seiji Takashio, Yasuhiro Izumiya, Eiichiro Yamamoto, Megumi Yamamuro, Kenichi Tsujita, Sunao Kojima, Koichi Kaikita, Ayami Kajiwara, Kazunori Morita, Kentaro Oniki, Junji Saruwatari, Kazuko Nakagawa, Yasuhiro Ogata, Kunihiko Matsui, Seiji Hokimoto,
Categorization as a cytochrome P450 (CYP) 2C19 poor metabolizer (PM) is reported to be an independent risk factor for cardiovascular disease. Epoxyeicosatrienoic acids (EETs) are metabolites of arachidonic acid by CYP2C19 epoxygenases and anti-inflammatory properties, especially in microvascular tissues. We examined the association of CYP2C19 polymorphisms and EETs on microvascular angina (MVA) caused by coronary microvascular dysfunction. We examined CYP2C19 genotypes in patients with MVA ( n = 71) and ...
Tópico(s): Alcohol Consumption and Health Effects
2016 - American Physical Society | AJP Heart and Circulatory Physiology
Asahito Hama, Hiroshi Yagasaki, Yoshiyuki Takahashi, Nobuhiro Nishio, Hideki Muramatsu, Nao Yoshida, Makito Tanaka, Hirokazu Hidaka, Nobuhiro Watanabe, Ayami Yoshimi, Kimikazu Matsumoto, Kazuko Kudo, Koji Kato, Keizo Horibe, Seiji Kojima,
To characterize childhood acute megakaryoblastic leukaemia (AMKL), we reviewed 45 children with AMKL diagnosed between 1986 and 2005 at Nagoya University Hospital and Japanese Red Cross Nagoya First Hospital. Twenty-four patients (53%) had AMKL associated with Down syndrome (DS-AMKL) and 21 (47%) had non-DS-AMKL. The median age of the DS-AMKL patients was 21 months (range, 8-38 months) and that of non-DS-AMKL patients was 15 months (range, 2-185 months). The morphology of blast cells was categorized into ...
Tópico(s): Lymphoma Diagnosis and Treatment
2008 - Wiley | British Journal of Haematology
Kiyotaka Kuzushima, Hiroshi Kimura, Yo Hoshino, Ayami Yoshimi, Ikuya Tsuge, Keizo Horibe, Tsuneo Morishima, Tatsuya Tsurumi, Seiji Kojima,
Epstein-Barr virus (EBV)—associated lymphoproliferative disorder (LPD) is a serious complication after allogeneic bone marrow transplantation (BMT). Dynamics of EBV-specific cytotoxic T lymphocytes (CTL), which are important in controlling EBV during the LPD, have not been fully elucidated. A patient with Wiskot-Aldrich's syndrome was diagnosed as suffering from LPD on day 47 after BMT. Fluorescence-activated cell sorter (FACS) analysis for interferon-γ production revealed that >70% of the patient's CD8+ ...
Tópico(s): Cytomegalovirus and herpesvirus research
2000 - Oxford University Press | The Journal of Infectious Diseases
Ayami Ochi, Takashi Takei, Akiko Ichikawa, Chiari Kojima, Takahito Moriyama, Mitsuyo Itabashi, Toshio Mochizuki, Atsuo Taniguchi, Kosaku Nitta,
Tópico(s): Metabolism and Genetic Disorders
2011 - Springer Science+Business Media | Clinical and Experimental Nephrology
Seiji Kojima, Keizo Horibe, Jun Inaba, Ayami Yoshimi, Yoshiyuki Takahashi, Kazuko Kudo, Koji Kato, Takaharu Matsuyama,
A total of 100 children under the age of 17 years with acquired aplastic anaemia (AA) were initially treated with immunosuppressive therapy (IST) ( n = 63) or bone marrow transplantation (BMT) ( n = 37) from an HLA‐matched family donor. The projected 10‐year survival rates were 55 ± 8% and 97 ± 3% respectively ( P = 0·004). Because the IST group included 11 non‐responders who were salvaged by BMT from an HLA‐matched unrelated donor, we compared failure‐free survival (FFS) between the groups. The probability of FFS ...
Tópico(s): Acute Lymphoblastic Leukemia research
2000 - Wiley | British Journal of Haematology
Seiji Kojima, Keizo Horibe, Jun Inaba, Ayami Yoshimi, Yoshiyuki Takahashi, Kazuko Kudo, Koji Kato, Takaharu Matsuyama,
A total of 100 children under the age of 17 years with acquired aplastic anaemia (AA) were initially treated with immunosuppressive therapy (IST) (n = 63) or bone marrow transplantation (BMT) (n = 37) from an HLA-matched family donor. The projected 10-year survival rates were 55 +/- 8% and 97 +/- 3% respectively (P = 0.004). Because the IST group included 11 non-responders who were salvaged by BMT from an HLA-matched unrelated donor, we compared failure-free survival (FFS) between the groups. The probability of FFS ...
Tópico(s): Transplantation: Methods and Outcomes
2000 - Wiley | British Journal of Haematology
Yoko Matsumura, Iwai Ohbayashi, Hiro Takahashi, Shoko Kojima, Nanako Ishibashi, Sumie Keta, Ayami Nakagawa, Rika Hayashi, Julio Sáez‐Vásquez, Manuel Echeverrı́a, Munetaka Sugiyama, Kenzo Nakamura, Chiyoko Machida, Yasunori Machida,
ABSTRACT Although the DEAD-box RNA helicase family is ubiquitous in eukaryotes, its developmental role remains unelucidated. Here, we report that cooperative action between the Arabidopsis nucleolar protein RH10, an ortholog of human DEAD-box RNA helicase DDX47, and the epigenetic repressor complex of ASYMMETRIC-LEAVES1 (AS1) and AS2 (AS1-AS2) is critical to repress abaxial (ventral) genes ETT/ARF3 and ARF4, which leads to adaxial (dorsal) development in leaf primordia at shoot apices. Double mutations ...
Tópico(s): Plant Gene Expression Analysis
2016 - The Company of Biologists | Biology Open
Wei‐Guang Ding, Ayami Tano, Xinya Mi, Akiko Kojima, Tomoyoshi Seto, Hiroshi Matsuura,
The phenylalkylamine class of L-type Ca2+ channel antagonist verapamil prolongs the effective refractory period (ERP) of human atrium, which appears to contribute to the efficacy of verapamil in preventing reentrant-based atrial arrhythmias including atrial fibrillation. This study was designed to investigate the molecular and electrophysiological mechanism underlying the action of verapamil on human Kv1.5 (hKv1.5) channel that determines action potential duration and ERP in human atrium.Site-directed ...
Tópico(s): Cardiac pacing and defibrillation studies
2019 - Karger Publishers | Cellular Physiology and Biochemistry