Kaveri R. Washimkar, Manendra Singh Tomar, Sharmeen Ishteyaque, Akhilesh Kumar, Ashutosh Shrivastava, Madhav Nilakanth Mugale,
... cause of cancer-related deaths. Benzo[a]pyrene (B[a]P), a polycyclic hydrocarbon, plays a pivotal role in ... Uncovering the molecular mechanism underlying the pathophysiology of B[a]P induced malignancy is crucial. Male Sprague Dawley rats were induced with B[a]P to generate a lung cancer model. The B[a]P administered rats show increased body and lung weight, ... architecture, and decreased survival. This study demonstrated that B[a]P upregulates activating transcription factor-6 (ATF6) and C/ ... Protein (CHOP) and induces endoplasmic reticulum (ER) stress. B[a]P also dysregulated mitochondrial homeostasis by upregulating, PTEN-induced ...
Tópico(s): Lipid metabolism and biosynthesis
2023 - Elsevier BV | Chemico-Biological Interactions
Wellcome Library, London. Image 10.9 cm x 13.8 cm. Series: Iconographic Collections.
0000 - Gale Group | NCCO Photography
Fengjun Lei, Yimeng Tian, Jingjing Miao, Luqing Pan, Ruixue Tong, Yueyao Zhou,
Benzo[a]pyrene (B[a]P), a typical PAHs widely existing in the marine environment, has been extensively studied for its immunotoxicity due to its ... Chlamys farreri were exposed at three concentrations of B[a]P (5, 10 and 15 μg/mL), and the effects of B[a]P on detoxification metabolism, signal transduction, humoral immune factors, ... AhR, ARNT and CYP1A1 were significantly induced by B[a]P at 12 h. Additionally, the content of B[a]P metabolite BPDE increased in a dose-dependent manner with pollutants. Under B[a]P stimulation, the expressions of PTK (Src, Fyn) and ...
Tópico(s): Immunotoxicology and immune responses
2022 - Elsevier BV | Fish & Shellfish Immunology
From Our Own Correspondent, From Our Military Correspondent, From Our Special Correspondent, From Our Parliamentary Correspondent, P. S. A. Rossdale., F. B. Dingle., Alfred T. Davies., Beryl Russell., J. Chinna Durai., G. H. Forster., E. March., From A Correspondent, Charles W. Goff., George Arthur., From Our Aeronautical Correspondent, !-Charles Villiers,
... of commodity prices in, Bank Of England Return, B.A. & P. Railway Interest Payment, Company Results, Spanish War Risk ...
1942 - Gale Group | TDA
Ignacio Martínez-Álvarez, Karyn Le Ménach, Marie-Hélène Devier, Miren P. Cajaraville, Hélène Budzinski, Amaia Orbea,
... µm), alone and with sorbed benzo(a)pyrene (B(a)P), in the embryo/larval stages of brine shrimps ... brine shrimp survival, while some treatments of plastics-B(a)P and all concentrations of B(a)P (0.1-10 mg/L) resulted acutely toxic. In zebrafish, only the highest concentrations of MPs-B(a)P and B(a)P caused a significant increase of malformation prevalence. Ingestion ... brine shrimps. In zebrafish embryos exposed to plastics-B(a)P, B(a)P appeared in the yolk sac of the embryos. The presence of B(a)P was also noticeable in brine shrimps exposed to ...
Tópico(s): Microplastics and Plastic Pollution
2022 - Multidisciplinary Digital Publishing Institute | Nanomaterials
Ernest Newman, E. N., Henry Jenner, John Murray, C. K. C. Andrew, W. C., Mrs. Florence M. Stock, Harrovial, Wm Weeks, J. M. Bulloch, Walter B. Paton, M. P., Tical, E. V. Lucas, W. G. Scott Moncrieff, James Agate, Frank Rutter, Mary Finch Cotton, Selwyn M. Day C. B., D. S. O., Edmund Gosse, George C. Stead, Victoria Herbert, Frederic William Wile, H. C. Minchin, Roland Atkinson, Leslie M. Oyler, Percival Hinton, L. Van Vliet, Wm. Harris, Dilys Powell, W. Bailey Kempling, Mr. Philip Snowden, Lord Birkenhead, Viscountess Rhondda, L. T., H. F., J. M. S., Sydney Brooks, J. L. Naimaster, R. J. Barrett Financial Editor, A. L. Felkin, Harold Cox,
... Criticism "The Text of Shakespeare's Hamlet." By B. A. P. Van Dam, M. D. (the Bodley Head. 21s.) ...
1924 - Gale Group | Sunday Times HA GDA
Mengyuan Li, Hong Liu, Hua Shao, Peng Zhang, Min Gao, Li Huang, Pingping Shang, Qiao Zhang, Wei Wang, Feifei Feng,
... explore the possible mechanisms, a benzo(a)pyrene [B(a)p] plus lipopolysaccharide (LPS)‐induced non‐diabetes mice model was established with B(a)p for 4 weeks and once a week (1 ... 10 μl/g body weight) 1 week before B(a)p were given to the mice until the animal ... incidence and mean tumor count of mice in B(a)P/LPS+Gly group were decreased compared with B(a)p/LPS group. Moreover, Gly could alleviate inflammatory changes ... tumor nest numbers compared with mice administrated with B(a)p/LPS in histopathological examination. The B(a)p/ ...
Tópico(s): Immune cells in cancer
2021 - Wiley | Environmental Toxicology
Douglas S. Smith, Ernest Newman, S. H. Byron, Sir John Simon M. P., Mr. Baldwin's Cigar, Rt. Hon. T. P. O'Connor M. P., Aaron Watson, Lady Kitty Vincent, Sir John Marriott M. P., Yarborough, H. D. Carver, J. H. Seabrooke, John S. C. Bridge, W. T. T. Elliott, Raleigh Egerton, Roland Atkinson ("Sunday Times" Paris Correspondent), E. V. Lucas, E. Lonsdale Deighton, James Agate, Frank Rutter, W. H. Hastings, Henry Knollys, Louis E. Stevenson, R. J. Bateman B. A., Edmund Gosse, T. H. Tennent (Major), George C. Stead, R. H. St. Clare Cater, H. C. Minchin, E. B. K., Maurice Baring, Viator, Roland Atkinson, C. P. Crane, Birdseye, L. Van Vliet, S. King Alcock, H. Askew, John E. Coleman, Eustacia, Brodie Fraser, G. P. Jacombrige, William Farren, Sir Herbert Morgan K. B. E., H. F., Pandora, H. A. B. Shrubb, Herbert Morrah President, Henry Murray, E. Newton Bungey, Carolus, John B. Kelly, R. J. Barrett Financial Editor, Harold Cox,
... Waziris "Waziristan, 1919-1920." By H. de Watteville, B. A., p. s. c., late Lieut.-Col. Royal Artillery and ...
1925 - Gale Group | Sunday Times HA GDA
Yun Luo, Baoqin Zhang, Ningbo Geng, Shuai Sun, Xiaoyao Song, Jiping Chen, Haijun Zhang,
... L02 hepatocytes after chlorination of benzo[a]pyrene (B[a]P) at 6 position. In general, 6-Cl-B[a]P produced a stronger toxicity to human hepatic cells than did parent B[a]P. When exposure concentrations were 5 and 50 nM, 6-Cl-B[a]P caused a weaker transcriptomic perturbation relative to B[a]P, whereas a stronger metabolomic perturbation, a stronger oxidative ... on cell viability were caused by 6-Cl-B[a]P than did parent B[a]P. Pathway enrichment analysis indicated that 6-Cl-B[a]P produced a more widely perturbation to metabolic pathways ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2021 - Elsevier BV | The Science of The Total Environment
FRANCIS A. STRINGER., T. A. BRAMSDON, M.P, R11.021., W. C. D. WHETHAM., JOHN C. MEDD., X., RONALD ROSS., BEN TILLETT., E. H. B., J. J., A UNIONIST CANDIDATE. December 27., STEPHEN GWYNN., J. M. F. FULLER., J. DICKERSON DAVIES., W. H. SOUTHON., G. F. FORBES., THORNTON A. WILLIAMS., FREDERICK POLLOCK., THE MAN IN THE STREET., S. HUTCHINSON HARRIS., WM. THOMPSON., B. A. C., L. GARDINER., E. RAY LANKESTER., ADAM SEDGWICK., WILLIAM CARRUTHERS., AUGUST BUSCK., W. AND A. GILBEY., JOHN WRIGHTSON., E. S. ZEBALLOS., BY A. CARNEGIE ROSS, C.B., H.B.M. CONSUL BUENOS AYRES., BY R. A. SANDALL, ACTING BRITISH CONSUL AT THE PORT OF SANTOS., BY A. C. KELLY, ASSOC.M.INST.C.E., BY CAPTAIN G. NUNEZ, OF THE MINISTRY OF MARINE., BY THE HON. JOHN BARRETT, DIRECTOR OF THE INTERNATIONAL BUREAU OF THE AMERICAN REPUBLICS., BY W. H. KOEBEL., BY LIX KLETT, CONSUL-GENERAL OF ARGENTINA IN RIO DE JANEIRO., BY DR. SANTIAGO G. O'FARRELL., BY PROFESSOR AGUSTIN ALVAREZ., BY THE FINANCIAL EDITOR OF THE "BUENOS AYRES STANDARD.", BY LADY SUSAN TOWNLEY., J. C. RODRIGUES., BY DR. ORVILLE A. DERBY, DIRECTOR OF THE BRAZILIAN GEOLOGICAL SURVEY., BY DR. OSWALDO GONCALVES CRUZ., BY SENOR TOBIAS MONTEIRO., BY PROFESSOR ERNESTO NELSON, DIRECTOR OF THE PEDAGOGICAL MUSEUM OF BUENOS AYRES., BY SEÑOR TOBIAS MONTEIRO.,
... Cabral & Co., The Glasgow Iron & Steel Co., Ltd., B.A.P., The Buenos Aires Great Southern Railway Company, Limited.. ...
1909 - Gale Group | TDA
Lynda Saber Cherif, Lei Cao-Lei, Sophie Farinelle, Claude P. Muller, Jonathan D. Turner, Henri Schroeder, Nathalie Grova,
The potent neurotoxicity of benzo[a]pyrene (B[a]P) has been suggested to be a susceptibility factor accelerating the onset of brain tumours and the emergence of neurobehavioural disturbances. B[a]P has been shown to be neurotoxic, acting directly ... like liver and gut. By using a realistic B[a]P exposure scenario (0.02–200 mg/kg/day, 10 days) in mice, we elucidated brain-specific B[a]P metabolism and at identified hydroxylated B[a]P metabolites in serum which could be used as markers of cognitive impairment. Repeated oral administration of B[a]P led to, at the doses of 20 and ...
Tópico(s): Molecular Sensors and Ion Detection
2021 - Multidisciplinary Digital Publishing Institute | Toxics
Ernest Newman, A. T. Johnson, Christopher Hollis, Adrian Hill, Walter Lippmann, Yarborough, Capt. Russell Grenfell R. N., W. Kay Robinson, Ralph Straus, Sydney Carroll, Sir Ross Barker, O. H. Brandon Special Correspondent of "The Sunday Times", Eric Newton, Norman Crump City Editor, J. Kilgour Grant, James Agate, R. H., Brig. E. C. Anstey D. S. O., Military Correspondent of "The Sunday Times", Desmond Shawe-Taylor, Harold Guard British United Press War Correspondent, D. R. Gent, Desmond MacCarthy, Frank MacDermot Special Correspondent of "The Sunday Times", The Rev. R. F. V. Scott, B. A. P. Winton Lewis A. R. I. B. A., E. Colston Shepherd Air Correspondent of "The Sunday Times", W. W. Hadley, Dilys Powell, Alexander Werth Special Correspondent of "The Sunday Times", J. Juchli, Wm. Tattersall, Aubrey Hammond "Sunday Times" Special Correspondent, Sir Noel Curtis-Bennett Political Correspondent, G. M. Trevelyan,
Gordon's Stands Supreme Big Day Raid on Germany Nearly 2,000 Planes: Hamm Railway Yards Hit Day-Long Attack on Europe Allies' Record Bombing Week: 19, ...
1944 - Gale Group | Sunday Times HA GDA
Yingying Yang, Luqing Pan, Yueyao Zhou, Ruiyi Xu, Jingjing Miao, Zhongyuan Gao, Dongyu Li,
Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH) compound in marine ecosystem, has great potential for chronic toxicity to marine animals. ... that reproductive system is the major target of B[a]P, but the adverse effects of B[a]P on subcellular fractions in bivalve gonads have not ... pollutants. This study was conducted to investigate how B[a]P affected the gonadal subcellular fractions, including plasma membrane, ... that mature gametes’ counts were significantly decreased in B[a]P-treated scallops. Three biological macromolecules (viz., DNA, lipids ...
Tópico(s): Toxic Organic Pollutants Impact
2021 - Elsevier BV | Environmental Pollution
Ernest Newman, A. T. Johnson, H. G., Mrs. Smith, Iain Lang "Sunday Times" War Correspondent, Gerard Hopkins, J. H. F. McEwen, W. Kay Robinson, Ralph Straus, Capt. Russell Grenfell R. N. Sunday Times Naval Correspondent, Harold Hobson, Chas Hymans, Sir William Crawford, Sir Warren Fisher, Aubrey Hammond Special Correspondent of "The Sunday Times", Eric Newton, Norman Crump City Editor, Mr. Nelson, Maurice Watts "Sunday Times" Special Correspondent, James Agate, Julia Herrick, D. J. Bradbury, R. H., Brig. E. C. Anstey D. S. O., "Sunday Times" Military Correspondent, A. G. Walkden M. P., Desmond Shawe-Taylor, D. R. Gent, Desmond MacCarthy, G. L. Schwartz, Sir Harold Spencer Jones, F. R. S. Astronomer Royal, Frank MacDermot Special Correspondent of "The Sunday Times", Stefan Osusky, E. Colston Shepherd Air Correspondent of "The Sunday Times", Ethel M. Wood, Mr. B. A. P. Winton-Lewis A. R. I. B. A., Westminster. S. W. 1, A. Frost, Christopher Hughes Mayor of Murlborough. Wilts, Edward Shanks, Dilys Powell, M. Kennedy, Alexander Werth Special Correspondent of "The Sunday Times", Rev. R. F. V. Scott D. D., G. L. S., James Orqubart M. A, Rex A. Dowson, Robert Auld, Lawrence Fairhall "Sunday Times" Special Correspondent, J. P. Jordan, Harold M. Abrahams, S. Turner, O. H. Brandon "Sunday Times" Special Correspondent, Mr. J. A. L. Duncan, D'arcy Dawson "Sunday Times" Special Correspondent,
Gordon's British Driving into Germany Armies & Commanders in Western Front Set-Up Gen. Dempsey Cuts Enemy Canal Line Germans Expect Air Landings Nazi Air ...
1944 - Gale Group | Sunday Times HA GDA
Jisheng Nie, Yu Zhang, Lijun Ning, Zhiwei Yan, Lei Duan, Hua-Xing Xi, Q. L. Niu, Qunwei Zhang,
Benzo[a]pyrene (B[a]P) is a ubiquitous carcinogenic pollutant in the environment, however, the potential neurotoxic effects of B[a]P has not been elucidated clearly. In the present ... potential involvement of p53 phosphorylation by Cdk5 in B[a]P-induced neuronal apoptosis at both in vitro and ... to 0, 10, 20, and 40 μM of B[a]P for 12, 24, or 48 h. For in ... 2.5, and 6.25 mg/kg of B[a]P every other day for 1, 2, or 3 months. Our results demonstrated that exposure to B[a]P caused a dose- and a time-dependent increase ...
Tópico(s): Cancer-related Molecular Pathways
2021 - Wiley | Environmental Toxicology
From Our Parliamentary Correspondent, From Our Own Correspondent, From Our Special Correspondent, Arthur Griffith-Boscawen., Frank J. Powell., D. S. Maccoll., A. T. Gardiner., From Our Special Correspondent In Rome, B. A. P. Winton-Lewis., Katherine Smith Pearse., F. S. Kennedy-Shaw., From A Correspondent, -J. L. Motley., Lionel Gough, Robert Graves.,
Births. Marriages. Deaths. Classified Advertising: Stamp Collecting, Opera And Ballet, Public Appointments. Display Advertising: Bury Felt Manufacturing ...
1944 - Gale Group | TDA
Yichen Lin, Chang‐Yi Wu, Chin‐Hwa Hu, Tun‐Wen Pai, Yet‐Ran Chen, Wen-Der Wang,
Benzo[a]pyrene (B[a]P) is a polycyclic aromatic hydrocarbon formed by the incomplete combustion of organic matter. Environmental B[a]P contamination poses a serious health risk to many ... many physiological systems. As such, chronic exposure to B[a]P is known to lead to locomotor dysfunction and ... model to delineate the acute toxic effects of B[a]P on the developing nervous system. We found that embryonic exposure of B[a]P downregulates shh and isl1, causing morphological hypoplasia in ... and hif2a) are repressed upon embryonic exposure of B[a]P, leading to reduced expression of the Hif-target ...
Tópico(s): Epigenetics and DNA Methylation
2020 - Multidisciplinary Digital Publishing Institute | Antioxidants
From Our Parliamentary Correspondent, From Our Aeronautical Correspondent, Our Parliamentary Correspondent, From Our Naval Correspondent, From Our Own Correspondent, From Our Correspondent, From Our Diplomatic Correspondent, From Our Special Correspondent, From Our Military Correspondent, Juliet Rhys-Williams., Thelma Cazalet Keir., Megan Lloyd George., Phillimore, P. Fleetwood-Hesketh., D. H. Leadbetter, George Arthur., From Our Special Correspondent In Central Burma, Eric Gillett., B. A. P. Winton-Lewis., From A Correspondent, Sydney Smith,
Births. Marriages. Deaths. Classified Advertising: Public Appointments, Opera And Ballet, Company Meeting Notices, Personal. News: Ten Killed By V Bombs, " ...
1945 - Gale Group | TDA
Linxuan Huang, Xiaofen Xiao, Yupeng Yao, Jianping Yu, Qingjian Chen, Puping Liang, Yan Zhang,
Abstract Objectives Benzo[a]pyrene (B[ a ]P) is a member of the polycyclic aromatic hydrocarbon (PAH) family. Although the potent carcinogenicity of high‐dose B[ a ]P has been extensively reported, the effects of long‐term exposure to B[ a ]P on the progression of tongue squamous cell carcinoma ( ... were treated with 5 or 50 nM of B[ a ]P for three months. The proliferation and chemoresistance of B[ a ]P‐treated cells to 5‐fluorouracil or cisplatin were detected by CCK8. The motility of the B[ a ]P‐treated cells was evaluated with wound healing analysis, ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2020 - Wiley | Oral Diseases
FROM OUR CORRESPONDENT, FROM OUR OWN CORRESPONDENT, FROM OUR SPECIAL CORRESPONDENT, FROM OUR RACING CORRESPONDENT, FROM OUR CRICKET CORRESPONDENT, From Our Own Correspondent, Our Diplomatic Correspondent, From Our Special Correspondent, FROM OUR AERONAUTICAL CORRESPONDENT, FROM OUR DIPLOMATIC CORRESPONDENT, From Our Parliamentary Correspondent, RONALD DAVISON., CHARLES GRANT ROBERTSON., H. W. EGLI, BENJAMIN DRAGE., DEREK HUDSON., GEORGE HILL., From a Correspondent lately in Cyrenaica, V. MILNER., W. N. LEAK., B. A. P. WINTON-LEWIS,
Births. Marriages. Deaths. Classified Advertising: Legal Notices, Exhibitions. News: Press Delegates At Coventry Visit To Bombed Area, Supplies For The ...
1946 - Gale Group | TDA
Han Gao, Guozhu Ye, Yi Lin, Yulang Chi, Sijun Dong,
Abstract Benzo[ a ]pyrene (B[ a ]P), a typical carcinogenic polycyclic aromatic hydrocarbon, exists worldwide in vehicle exhaust, cigarette smoke and other polluted environments. Recent studies have demonstrated a strong association between B[ a ]P and lung cancer. However, whether B[ a ]P at human blood equivalent level can promote epithelial‐ ... during cell malignant transformation, remains unclear. Besides, whether B[ a ]P facilitates this progress via aryl hydrocarbon receptor (AhR) ... transwell assay showed that 5 μg/L of B[ a ]P promoted BEAS‐2B cell invasion and migration. In ...
Tópico(s): Cancer Cells and Metastasis
2020 - Wiley | Journal of Applied Toxicology
THOMAS HOLTBY. Great Driffield, Nov. 17., J. M. KEYNES. King's College, Cambridge, Nov. 21., P. D. LEAKE. 25, Abchruch-lane, E.C.4., P. E. ROBERTS. Worcester College, Oxford, Nov. 21., MUIRHEAD BONE. Burlington Fine Arts Club, W., Nov. 23. The additional signatures to Mr. Muirhead Bone's letter are:LORD HENRY BENTINCK, M.P., R. B. CUNNINGHAME GRAHAM, FRANOIS DODD, A.R.W.S., HENRY, M. FLETCHER, F.R.I.B.A., EDWARD GARNETT, H. S. GOODHART-RENDEL, F.R.I.B.A., SIR E. MARSHALL-HALL, K.C., C. LEWIS HIND, FRANCIS HOWARD, PROFESSOR SELWYN IMAGE, HOLBROOK JACKSON, AUGUSTS E. JOHN, A.R.A., EDMOND X. KAPP, RALPH KNOTT, F.R.I.B.A., P. G. KONODY, GEORGE MOORE, SIR ALFRED MOND, M.P., HENRY W. NEVINSON, C.R. W. NEVINSON, SIR WILLIAM ORPEN, R.A., FRANK PICK, NIGEL PLAYFAIR, BERTRAM PRIESTMAN, R.A., HALSEY RICHARDO, PROFESSOR A. E. RICHARDSON, V. RIENAECKER, HOWARD ROBERTSON, HENRY RUSHBURY, A.R.W.S., ALGERNON TALMAGE, A.R.A., BEN TILLETT, LEON UNDERWOOD, C. F. A. VOYSEY, E. WADSWORTH, PROFESSOR HUBERT WORTHINGTON, and DR. HAGBERG WRIGHT., SESOSTRIS SIDAROUSS, Chargé d'Affaires. Légation Royale d'Egypte à Londres, Nov 23., M.M., CALLISTHENES, Our Parliamentary Correspondent, ARTHUR LAWLEY. 9, Seymour-street, Portman-square, W.1., J. A. R. MARRIOTT. House of Commons, Nov. 20., THOMAS SCOTT, Secretary. Mercantile Marine Service Association, Towerbuilding, Water-street, Liverpool., W. R. MAINPRICE, Director. Brown, Bayley's Steel Works, Limited, Leedsroad, Sheffield, Nov. 17., M.C.R., J. ROGER PRESTON, 104, High Hoilborn, W.C.I, Nov. 23.,
Births. Marriages. Deaths. Classified Advertising: Transfer Books., Nursing Homes., J. H. KENYON, Ltd., Funeral Furnishers, Cremators., Bonds Cancelled., ...
1925 - Gale Group | TDA
Contaminations of benzo[a]pyrene (B[a]p) in food is the main source of B[a]p exposure to humans. B[a]p as one of the most studied polycyclic aromatic ... current theoretical study revealed that biological detoxification of B[a]p is an environmentally friendly and cost-effective method. ... and LAB cells in in-vitro binding with B[a]p and in in-vivo anti-carcinogenicity and anti-mutagenicity against B[a]p and the whole overview of detoxification mechanism in ... of probiotics and LABs in the removal of B[a]p. This research will be utilized in the food ...
Tópico(s): Tea Polyphenols and Effects
2020 - Elsevier BV | Trends in Food Science & Technology
Xinxin Ye, Jingjing Ma, Junling Wei, Kai Sun, Qizhong Xiong,
... of the hydrophobic organic contaminant benzo[a]pyrene (B[a]P) is extremely important for assessing its environmental risk. The effect of addition manner of B[a]P on the bioavailability and toxicity of B[a]P in soil remains unclear. In this study, soil samples, spiked with B[a]P by one-time or multiple-time additions, were tested to investigate the available fraction of B[a]P in soils, the uptake of B[a]P by red wiggler worms ( Eisenia fetida ), as well ... periods. Results showed that the available fraction of B[a]P in soils and the amount of B[a] ...
Tópico(s): Microbial bioremediation and biosurfactants
2019 - Nature Portfolio | Scientific Reports
Tao Qi, Jinxing Li, Yuankun Liu, Jipeng Luo, Qiang Xu, Bing Li, Qiquan Li, Tingqiang Li, Changquan Wang,
... phytoremediation of cadmium (Cd) and benzo(a)pyrene (B[a]P) co-contaminated soil using Cd-hyperaccumulator Sedum alfredii. Results showed that B[a]P-degrading bacterium (Ochrobactrum intermedium B[a]P-16) inoculation significantly increased root (by 22.1– ... 2 g L−1 extracted more Cd and B[a]P than water, saponin enhanced Cd and B[a]P bioavailability in soil and thus promoted their uptake and accumulation in S. alfredii. The activity of B[a]P-16, dehydrogenase and polyphenol oxidase in co-contaminated ... by growing S. alfredii, and the application of B[a]P-16 and saponins caused a significant (P < 0. ...
Tópico(s): Microbial bioremediation and biosurfactants
2019 - Elsevier BV | Chemosphere
Anthony C. Umeh, Logeshwaran Panneerselvan, Luchun Duan, Ravi Naidu, Kirk T. Semple,
... a soil containing readily available benzo[a]pyrene (B[a]P) and highly sequestered B[a]P NERs aged in soil for 350 days. B[a]P bioaccumulation was assessed and DNA damage (as DNA ... were evaluated by comet assay. The concentrations of B[a]P in earthworm tissues were generally low, particularly when the soil contained highly sequestered B[a]P NERs, with biota-soil accumulation factors ranging from ... 05) in the spiked soil containing readily available B[a]P than in soil that did not have added B[a]P. For example, for the soil initially spiked at ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2019 - Elsevier BV | The Science of The Total Environment
Li Huang, Shuyin Duan, Hua Shao, Aihua Zhang, Shuang Chen, Peng Zhang, Na Wang, Wei Wang, Yongjun Wu, Jing Wang, Hong Liu, Wu Yao, Qiao Zhang, Feifei Feng,
... to lung tumorigenesis induced by benzo(a)pyrene [B(a)p] in C57BL/6J mice and the role of ... mice (wide-type, WT) were instilled intratracheally with B(a)p (1 mg/mouse) once a week for 4 times [the week of the last time of B(a)p treatment named Week 0], and mice were then ... of lung tumor were analyzed.Mice exposed to B(a)p or B(a)p plus LPS could induce lung tumors, whereas LPS ... could not induce lung tumorigenesis. In WT mice, B(a)p plus LPS exposure significantly increased tumor incidence, mean ... size of visible tumors of lungs compared with B(a)p treatment alone, and NLRP3 deletion inhibited lung tumorigenesis ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2019 - BioMed Central | Respiratory Research
Saroj Kumar Das, Sai Aparna, Manorama Patri,
Benzo[a]pyrene (B[a]P), a prototype of polycyclic aromatic hydrocarbons (PAHs), is an ubiquitous and notable anthropogenic toxicant. The escalating load of anthropogenic ... zebrafish model to address the potential role of B[a]P in inducing neurodegenerative disease like phenotypes. Waterborne B[a]P exposure was performed for a stipulated period of ... to study the effect on their behaviour before B[a]P exposure. The findings of the present study advocate that chronic exposure to B[a]P significantly impairs the locomotor activity in zebrafish, which ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2019 - Elsevier BV | Neuroscience Letters
Durgesh Nandini Das, Sujit K. Bhutia,
Food-borne Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon, exposure is one of the major concerns associated with a risk of cancer development. The aggregative environmental pollution has increased B[a]P contamination in grilled and barbecued meat, vegetables, oils, ... high dietary intake in the worldwide human population. B[a]P activation through cytochrome P450 leads to generate active ... form adducts causing mutations to initiate carcinogenesis. Moreover, B[a]P-dependent reactive oxygen species production and mitochondrial damage ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
2018 - Elsevier BV | Current Opinion in Food Science
Jia‐Ching Wu, Mei‐Ling Tsai, Ching‐Shu Lai, Chih‐Yu Lo, Chi‐Tang Ho, Ying‐Jan Wang, Min‐Hsiung Pan,
... PMFs on benzo[ a ]pyrene/dextran sulfate sodium (B a P/DSS)‐induced colorectal tumorigenesis in ICR mice. We found that PMFs significantly prevented B a P/DSS‐induced colorectal tumor formation. B a P mutagenic metabolite and DNA adducts were found to ... the PMFs‐treated groups through the modulation of B a P metabolism. At the molecular level, the results of RNA‐sequencing indicated that PMFs ameliorated B a P/DSS‐induced abnormal molecular mechanism change including activated ... induced metastasis genes. The autophagic defect caused by B a P/DSS‐induced tumorigenesis was improved by pretreatment with ...
Tópico(s): Sesame and Sesamin Research
2017 - Wiley | International Journal of Cancer