Arne Schneidewind, Yanhua Tang, Mark A. Brockman, Elizabeth G. Ryland, J Dunkley-Thompson, J Steel-Duncan, M. Anne St. John, Joseph A. Conrad, Spyros A. Kalams, Francine Noël, Todd M. Allen, C D C Christie, Margaret E. Feeney,
ABSTRACT Expression of HLA-B57 is associated with restricted replication of human immunodeficiency virus (HIV), but the mechanism for its protective effect remains unknown. If ... advantage depends upon CD8 T-cell recognition of B57-restricted epitopes, mother-to-child transmission of escape ... could nullify its protective effect. However, if the B57 advantage is largely mediated by selection for fitness-attenuating viral mutations within B57-restricted epitopes, such as T242N in TW10-Gag, ... the haploidentical infant. We assessed the consequences of B57-associated mutations on replication capacity, viral control, and ...
Tópico(s): HIV/AIDS drug development and treatment
2009 - American Society for Microbiology | Journal of Virology
Jing Xie, Wei Lu, Assia Samri, Dominique Costagliola, Aurélie Schnuriger, Bosco Christiano Maciel da Silva, Catherine Blanc, Martin Larsen, Ioannis Theodorou, Christine Rouzioux, Brigitte Autran,
... specific for HIV-Gag and Nef in HLA-B57/5801-positive and negative nonprogressors.A head-to- ... production and differentiation was conducted, in 11 HLA-B57/5801 and 11 HLA-B57/5801 HIV-infected individuals selected from a cohort ... differ for IL-2 production in either HLA-B57/5801 or HLA-B57/5801 individuals. The IFN-gamma-producing Gag-specific CD8(+) T cells in HLA-B57/5801 individuals significantly differed from their Nef-specific ... This differentiation pattern was not observed in HLA-B57/5801 individuals. Only these HLA-B57/5801-positive ...
Tópico(s): T-cell and B-cell Immunology
2010 - Lippincott Williams & Wilkins | AIDS
Michael A. Norcross, Shen Luo, Li Lu, Michael T. Boyne, Mary Gomarteli, Aaron D. Rennels, Janet Woodcock, David H. Margulies, Curtis McMurtrey, Stephen Vernon, William H. Hildebrand, Rico Buchli,
... in HIV-treated patients is associated with HLA-B57:01 expression. To understand the immunochemistry of abacavir ... we investigated the effects of abacavir on HLA-B57:01 epitope-binding in vitro and the quality and quantity of self-peptides presented by HLA-B57:01 from abacavir-treated cells.An HLA-B57:01-specific epitope-binding assay was developed to ... whether abacavir alters the peptide repertoire in HLA-B57:01, a B-cell line secreting soluble human ... the FITC-labeled self-peptide LF9 to HLA-B57:01 in a dose-dependent manner. Endogenous peptides ...
Tópico(s): Urticaria and Related Conditions
2012 - Lippincott Williams & Wilkins | AIDS
Mary Carrington, Ronald E. Bontrop,
... term nonprogressors (LTNP) have indicated the plasticity of B57 responses against HIV-1. CTL responses restricted by B57 molecules target multiple HIV-1 peptides, with predominant ... and reverse transcriptase motifs [34,35] and strong B57-restricted CTL responses can occur against overlapping peptides ... so it is unlikely that this property of B57 responses completely accounts for long term nonprogression to disease in B57+ patients. Studies have shown that differential epitope recognition ... that carry B*57 tend to involve HLA-B57-restricted CTL epitopes as compared to epitopes restricted ...
Tópico(s): T-cell and B-cell Immunology
2002 - Lippincott Williams & Wilkins | AIDS
Yanhua Tang, Sihong Huang, J Dunkley-Thompson, J Steel-Duncan, Elizabeth G. Ryland, M. Anne St. John, Rohan Hazra, C D C Christie, Margaret E. Feeney,
... infection expressing the protective human leukocyte antigen (HLA)-B57 allele. Design: The frequency, epitope specificity, and functional ... HIV-specific T cells and sequence variation within B57-restricted epitopes were compared between ‘spontaneous controllers’ who ... immunosorbent spot. Functional characterization of CD8 cells targeting B57 epitopes was performed by staining for cytokine production ( ... determine the prevalence of viral escape mutations within B57-restricted epitopes and associated compensatory mutations. Results: HLA- ...
Tópico(s): Cytomegalovirus and herpesvirus research
2010 - Lippincott Williams & Wilkins | AIDS
Christine A. Jansen, Stefan Kostense, Kristin Vandenberghe, Nening M. Nanlohy, Iris M. De Cuyper, Erwan Piriou, Erik H. Manting, Frank Miedema, Debbie van Baarle,
HLA-B57 has been shown to be associated with long-term asymptomatic HIV-1 infection. To investigate the biological mechanism by which the HLA-B57 allele could protect from HIV-1 disease, we ... Gag peptides presented by HLA-A2, -B8 or -B57. T cells specific for the HLA-B57 peptide KAFSPEVIPMF responded more readily and to a ... reproducible with T cells from individuals expressing HLA-B57 in combination with one or both of the ... the same protein presented by different HLA molecules. B57-restricted KAFSPEVIPMF-specific CD8(+) T cells have relatively ...
Tópico(s): T-cell and B-cell Immunology
2004 - Wiley | European Journal of Immunology
... nutrient solutions, the corn ( Zea mays L.) inbred B57 grew considerably better at low Mg levels and was more Mg‐efficient than the inbred Oh40B. B57 produced maximum dry‐matter yields near 0.12m ... to 4.1m M of Mg. Roots of B57 contained lower Mg concentrations than roots of Oh40B ... higher Mg concentrations at higher Mg levels. However, B57 leaves contained nearly twice as much Mg as ... increased. In nearly all plants, the decrease in B57 was greater at the lower levels of Mg ... Mn, Zn, B, and Cu were lower for B57 than for Oh40B. When B57 and Oh40B were ...
Tópico(s): Magnesium in Health and Disease
1975 - Wiley | Soil Science Society of America Journal
Marcus Altfeld, Marylyn M. Addo, Eric Rosenberg, Frederick Hecht, Paul K. Lee, Martin Vogel, Xu G. Yu, Rika Draenert, Mary N. Johnston, Daryld Strick, Todd M. Allen, Margaret E. Feeney, James O. Kahn, Rafick‐Pierre Sékaly, Jay A. Levy, Jürgen K. Rockstroh, Philip JR Goulder, Bruce D. Walker,
HLA-B57, as well as cytotoxic T-lymphocyte (CTL) responses restricted by this allele, have been strongly associated with ... early HIV-1 infection in individuals expressing HLA-B57 were assessed. HIV-1-specific T-cell responses ... flow-based intracellular cytokine quantification.Individuals expressing HLA-B57 presented significantly less frequently with symptomatic acute HIV- ... CD8 T-cell responses were dominated by HLA-B57-restricted responses, with significantly broader (P < 0.02) ... stronger (P < 0.03) responses restricted by HLA-B57 than restricted by all other co-expressed HLA ...
Tópico(s): Cytomegalovirus and herpesvirus research
2003 - Lippincott Williams & Wilkins | AIDS
Marjon Navis, Ingrid M. M. Schellens, Debbie van Baarle, José A. M. Borghans, Peter van Swieten, Frank Miedema, Neeltje A. Kootstra, Hanneke Schuitemaker,
Abstract HLA B57 and the closely related HLA B5801 are over-represented among HIV-1 infected long-term nonprogressors (LTNPs). It has been suggested that this association between HLA B57/5801 and asymptomatic survival is a consequence of ... immune control. In this study we compared HLA B57/5801 HIV-1 infected progressors and LTNPs for ... and potential compensatory mutations were similar in HLA B57/5801 LTNPs and progressors. Both groups were also ... ELISPOT analysis. Interestingly, HIV-1 variants from HLA B57/5801 LTNPs had much lower replication capacity than ...
Tópico(s): T-cell and B-cell Immunology
2007 - American Association of Immunologists | The Journal of Immunology
Cesar Oniangue-Ndza, Thomas Kuntzen, Michael Kemper, Andrew Berical, Yaoyu E. Wang, Christoph Neumann‐Haefelin, Peter K. Foote, Kelsey Hills-Evans, Laura L. Reyor, Katherine Kane, Adrianne D. Gladden, Allyson K. Bloom, Karen A. Power, Robert Thimme, Georg M. Lauer, Matthew R. Henn, Arthur Y. Kim, Todd M. Allen,
ABSTRACT While human leukocyte antigen B57 (HLA-B57) is associated with the spontaneous clearance of hepatitis C virus (HCV), the mechanisms behind this control remain unclear. Immunodominant CD8 + T cell responses against the B57-restricted epitopes comprised of residues 2629 to 2637 ... might impair viral replication and contribute to the B57-mediated control of HCV. Common CTL escape mutations ... part to the control of HCV replication in B57-positive individuals and that persistence of HCV in B57-positive individuals may involve the development of specific ...
Tópico(s): HIV/AIDS drug development and treatment
2011 - American Society for Microbiology | Journal of Virology
Michèl R. Klein, C J Melief, A M Holwerda, Frank Miedema, Sjoerd H. van der Burg, Jan W. Drijfhout, Egbert Hovenkamp,
HLA-B57 has been shown to be strongly associated with slow disease progression in human immunodeficiency virus type 1 ( ... cells, we sought to characterize the dominant HLA-B57-restricted CTL responses at the epitope level. It was found that HLA-B57-restricted CTL responses were targeted at multiple proteins ... 249), which had previously been reported as HLA-B57-restricted. The RT-specific CTL response in one ... for > 10 years and was dominated by HLA-B57-restricted CTL that recognized the newly defined epitope ...
Tópico(s): T-cell and B-cell Immunology
1998 - Microbiology Society | Journal of General Virology
Eleanor Mallon, Clareann H. Bunker, Roger Newson,
... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population ...
Tópico(s): T-cell and B-cell Immunology
1999 - Elsevier BV | Journal of Investigative Dermatology
Andrej Košmrlj, Elizabeth L. Read, Qi Ying, Todd M. Allen, Marcus Altfeld, Steven G. Deeks, Florencia Pereyra, Mary Carrington, Bruce D. Walker, Arup K. Chakraborty,
... are enriched in these individuals, most prominently HLA-B57. The paper provides a model of how elite ... response against HIV. According to the model, HLA-B57 binds fewer self-peptides, resulting in a T- ... AIDS. Certain HLA class I alleles, notably HLA-B57, are enriched in elite controllers. Here a model ... immune response against HIV. In this model, HLA-B57 binds to fewer self-peptides, resulting in a ... controllers, with the highest association observed for HLA-B57 (ref. 1). Because HLA molecules present viral peptides ...
Tópico(s): T-cell and B-cell Immunology
2010 - Nature Portfolio | Nature
Margaret E. Feeney, Yanhua Tang, Katja Pfafferott, Kathleen Roosevelt, Rika Draenert, Alicja Trocha, Xu G. Yu, Cori L. Verrill, Todd M. Allen, Corey Moore, S. Mallal, Sandra Burchett, Kenneth McIntosh, Stephen I. Pelton, M. Anne St. John, Rohan Hazra, Paul Klenerman, Marcus Altfeld, Bruce D. Walker, Philip Goulder,
... response of perinatally infected children to an epitope (B57-TW10) that is targeted early during acute HIV-1 infection in adults expressing HLA-B57 and rapidly mutates under this selection pressure. Viral ... universal presence of escape mutations within TW10 among B57- and B5801-positive children. Mutations in TW10 and other B57-restricted epitopes arose early following perinatal infection of B57-positive children born to B57-negative mothers. Surprisingly, the majority of B57/5801-positive children exhibited a robust response to ...
Tópico(s): Herpesvirus Infections and Treatments
2005 - American Association of Immunologists | The Journal of Immunology
Tai‐Gyu Kim, Ho Jae Han, Hyejung Lee, Jai Il Youn, Tae‐Yoon Kim,
... with the HLA-A1, A2, A30, B13, B17 (B57, B58), B37, B39, B46, Cw6, Cw7, Cw9, Cw11, ... with psoriasis. The frequencies of HLA-A2, -B39, -B57, -B27, and -Cw*0101, however, were slightly increased, ... find a significant elevation of HLA-A2, B17 (B57 and B58), -B39, -B46, Cw7, and Cw11, although the frequencies of HLA-A2, -B39, and -B57 were slightly increased in Korean psoriasis patients. In ... DR7-DQ2 (13.1) and HLA-A1-Cw6–B57-DRB1*07-DQA1*0201-DQB1*0303 (57.1) ... class I side of the extended haplotype Cw6–B57-DRB1*0701-DQA1*0201-DQB1*0303: a population- ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2000 - Elsevier BV | Journal of Investigative Dermatology
Catherine A. Brennan, F. Javier Ibarrondo, Catherine A. Sugar, Mary Ann Hausner, Roger Shih, Hwee L. Ng, Roger Detels, Joseph B. Margolick, Charles R. Rinaldo, John Phair, Lisa P. Jacobson, Otto O. Yang, Beth D. Jamieson,
Although HLA-B*57 (B57) is associated with slow progression to disease following HIV-1 infection, B57 heterozygotes display a wide spectrum of outcomes, including ... and elite control. Efforts to identify differences between B57-positive (B57(+)) slow progressors and B57(+) rapid progressors have largely focused on cytotoxic T ... early HIV-1-specific CTL responses of 14 B57(+) individuals whose time to development of disease ranged ...
Tópico(s): T-cell and B-cell Immunology
2012 - American Society for Microbiology | Journal of Virology
Shokrollah Elahi, Shima Shahbaz, Stan Houston,
... and HLA-B*35:02), HLA-B*27/B57 and non-HLA-B*27/B57 (e.g. HLA-A*01, A*02, A* ... compared with those restricted by HLA-B*27/B57 and even non-HLA-B*27/B57. CD8+ T cells restricted by non-HLA-B*27/B57 when encountered their cognate epitopes upregulated TIM-3 ... CD8+ T cells restricted by HLA-B*27/B57. Instead, CD8+ T cells restricted by HLA-B* ...
Tópico(s): HIV Research and Treatment
2020 - Public Library of Science | PLoS Pathogens
Natacha Mérindol, Mohamed El‐Far, Mohamed Sylla, Nasser Masroori, Caroline Dufour, Jiaxin Li, Pearl Cherry, Mélodie B. Plourde, Cécile Tremblay, Lionel Berthoux,
... by prolonged viremia suppression. HLA alleles B27 and B57 promote the cytotoxic T lymphocyte (CTL)-mediated depletion ... we investigated the targeting of CA from B27/B57+ individuals by cytosolic antiviral factors Mx2 and TRIM5α. ... HIV-1 vectors using CA isolated from B27/B57+ or control subjects. HIV-1 vectors containing B27/B57+-specific CA had increased sensitivity to TRIM5α but ...
Tópico(s): interferon and immune responses
2018 - Public Library of Science | PLoS Pathogens
Christian Brander, Yves Rivière,
... include, among others, the HLA-B27 and HLA-B57 alleles. Interestingly, in HLA-B27 positive individuals, the ... population [51,52]. In the case of HLA-B57, a recent report characterized the evolution of CTL ... be heavily dominated by CTL restricted by HLA-B57. This again is evidence that at least some ... is further supported by the observation that HLA-B57 expressing individuals are under-represented in our acute ... manner than individuals that do not express HLA-B57 and therefore rarely present at the HIV clinic. ...
Tópico(s): T-cell and B-cell Immunology
2002 - Lippincott Williams & Wilkins | AIDS
Warren L. Dinges, Julia Richardt, David Friedrich, Emilie Jalbert, Yi Liu, Claire E. Stevens, Janine Maenza, Ann C. Collier, Daniel E. Geraghty, Jeremy Smith, Zoe Moodie, James I. Mullins, M. Juliana McElrath, Helen Horton,
HLA alleles B57/58, B27, and B35 have the strongest genetic associations with HIV-1 disease progression. The mechanisms of these ... T-cell responses to conserved HIV epitopes within B57/58 alleles (TW10 and KF11) and B27 alleles ( ... progression. The plasma viral load was higher in B57/58(+) and B27(+) subjects lacking the conserved B57/58- and B27-restricted responses. The presence of certain B57/58-, B27-, and B35-restricted HIV-specific CD8(+) ...
Tópico(s): T-cell and B-cell Immunology
2010 - American Society for Microbiology | Journal of Virology
Benjamin Descours, Véronique Avettand-Fènoël, Catherine Blanc, Assia Samri, Adeline Mélard, Virginie Supervie, Ioannis Theodorou, Guislaine Carcelain, Christine Rouzioux, Brigitte Autran,
... 27 or HLA-B*57 alleles (HLA-B27/B57). Results. A remarkably lower infection level of central ... an exclusive feature that distinguished the HLA-B27/B57 HIV reservoirs from the other ones. In LTNPs, ... Gag-specific CD8 T cells. In HLA-B27/B57 LTNPs, a lower activation level of their memory ... target [E/T]). As a result, HLA-B27/B57 E/T ratios were negatively correlated with the ... antiviral immunity governed by the protective HLA-B27/B57 alleles, by limiting TCM infection and pool exhaustion, ...
Tópico(s): T-cell and B-cell Immunology
2012 - Oxford University Press | Clinical Infectious Diseases
Nicole Frahm, Sharon Adams, Photini Kiepiela, Caitlyn Linde, Hannah S. Hewitt, Mathias Lichterfeld, Kaori Sango, Nancy V. Brown, Eunice Pae, Alysse G. Wurcel, Marcus Altfeld, Margaret E. Feeney, Todd M. Allen, Timothy Roach, M. Anne St. John, Eric S. Daar, Eric Rosenberg, Bette Korber, Francesco M. Marincola, Bruce D. Walker, Philip Goulder, Christian Brander,
... alleles, shares the epitope binding motif of HLA-B57 and HLA-B58, two alleles that have been ... in breadth and specificity to those of HLA-B57/58-positive subjects and whether HLA-B63-positive ... individuals indeed mounted responses to previously identified HLA-B57-restricted epitopes as well as towards novel, HLA- ... that, in turn, can be presented by HLA-B57 and HLA-B58. HLA-B63-positive subjects generated ...
Tópico(s): T-cell and B-cell Immunology
2005 - American Society for Microbiology | Journal of Virology
Jesús Martínez‐Borra, Chaim Brautbar, Segundo González, Claes D. Enk, Antonio López‐Vázquez, Carlos López‐Larrea,
... In particular, no significant association of B13 and B57 alleles with disease susceptibility was found. A considerable ... 251T-CDSN*TTC123.3 (0.2–30.9)B57-Cw6- C1_4_4(384)-OTF3B-251T-CDSN*TTC123.3 (0.2–30.9)B57-Cw7- C1_4_4(384)-OTF3B-251T-CDSN* ... explain why different psoriatic HLA-Cw6-bearing haplotypes (B57-Cw6, B13-Cw6 and B37-Cw6) appear to ... classically associated with psoriasis as B13-Cw6 and B57-Cw6. Although the B65-Cw8-C1_4_4( ...
Tópico(s): T-cell and B-cell Immunology
2005 - Elsevier BV | Journal of Investigative Dermatology
Segundo González, Jesús Martínez‐Borra, Antonio López‐Vázquez, Miguel Ángel Blanco-Gelaz, Carlos López‐Larrea, J. Sánchez del Río, Jorge Santos‐Juanes,
... have also been associated with PV (B13, B47, B57). Nevertheless, it has been established that the primary ... class I side of the extended haplotype Cw6–B57-DRB*0701-DQA1*0201-DQB*0303: a population ... used to genotype B13, B38, B39, B47 and B57 alleles (Bunce et al., 1995Bunce M. Fanning G. ... to take part in the B13.1 and B57.1 ancestral haplotypes and the associations of B* ... linkage disequilibrium with MICA A5.1 and HLA-B57 in linkage disequilibrium with MICA A9. We have ...
Tópico(s): Dermatology and Skin Diseases
2000 - Elsevier BV | Journal of Investigative Dermatology
Toshiyuki Miura, Mark A. Brockman, Arne Schneidewind, Michael A. Lobritz, Florencia Pereyra, Almas Rathod, Brian L. Block, Zabrina L. Brumme, Chanson J. Brumme, B.M. Baker, Alissa C. Rothchild, Bin Li, Alicja Trocha, Emily Cutrell, Nicole Frahm, Christian Brander, Ildikó Tóth, Eric J. Arts, Todd M. Allen, Bruce D. Walker,
... but the mechanisms of control remain unclear. HLA-B57 and the closely related allele B*5801 are ... TW10 epitope sequences in residual replicating viruses in B57/B*5801 EC and the extent to which ... we analyzed TW10 in a total of 50 B57/B*5801-positive subjects (23 EC and 27 ...
Tópico(s): HIV/AIDS drug development and treatment
2008 - American Society for Microbiology | Journal of Virology
Brenna C. Simons, Scott E. VanCompernolle, Rita M. Smith, Jie Wei, Louise Barnett, Shelly L. Lorey, Dirk Meyer‐Olson, Spyros A. Kalams,
... cell clonotypes directed against a dominantly recognized HLA B57-restricted epitope (KAFSPEVIPMF; KF11) and identified common usage ... β-chain TRBV7 in eight of nine HLA B57 subjects examined, regardless of HLA B57 subtype. Despite this convergent TCR gene usage, structural ...
Tópico(s): T-cell and B-cell Immunology
2008 - American Association of Immunologists | The Journal of Immunology
Toshiyuki Miura, Zabrina L. Brumme, Mark A. Brockman, Pamela C. Rosato, Jennifer Sela, Chanson J. Brumme, Florencia Pereyra, Daniel E. Kaufmann, Alicja Trocha, Brian L. Block, Eric S. Daar, Elizabeth Connick, Heiko Jessen, Anthony D. Kelleher, Eric Rosenberg, Martin Markowitz, Kim Schafer, Florin Vaida, Aikichi Iwamoto, Susan J. Little, Bruce D. Walker,
... 5%], P = 0.018). Moreover, of two HLA-B57-positive (B57(+)) controllers identified, both harbored, at the earliest time ... resistance mutations; intriguingly, two of them displayed typical B57 signature mutations (T242N), suggesting the acquisition of attenuated viruses from B57(+) donors. These data indicate that acute/early stage ...
Tópico(s): HIV/AIDS drug development and treatment
2010 - American Society for Microbiology | Journal of Virology
Mark A. Brockman, Arne Schneidewind, Matthew Lahaie, Aaron G. Schmidt, Toshiyuki Miura, Ivna DeSouza, Faina Ryvkin, Cynthia A. Derdeyn, Susan Allen, Eric Hunter, Joseph Mulenga, Paul Goepfert, Bruce D. Walker, Todd M. Allen,
... T-cell escape mutation in the dominant HLA-B57-restricted Gag epitope TW10 (TSTLQEQIGW) has been shown ... in the cyclophilin A (CypA)-binding loop in B57(+) individuals with progressive disease. In an independent cohort ... to the slower disease progression associated with HLA-B57.
Tópico(s): HIV/AIDS drug development and treatment
2007 - American Society for Microbiology | Journal of Virology
Lyudmila Kostenko, Lars Kjer‐Nielsen, I. Nicholson, F. Hudson, Andrew Lucas, Bree Foley, K. Chen, Kole Lynch, Jenny Nguyen, A. H. B. Wu, Brian D. Tait, Rhonda Holdsworth, S. Mallal, Jamie Rossjohn, Mandvi Bharadwaj, James McCluskey,
HLA‐B57 and HLA‐B58 are major histocompatibility class (MHC)‐I allotypes that are potentially predictive of important clinical ... describe a monoclonal antibody (mAb) specific for HLA‐B57 and HLA‐B58 that provides an inexpensive and ... these MHC‐I allotypes. The usefulness of HLA‐B57 screening for prediction of abacavir hypersensitivity was shown ...
Tópico(s): Contact Dermatitis and Allergies
2011 - Wiley | Tissue Antigens
A. Martin, R. Krueger, Coral Ann Almeida, David Nolan, Elizabeth J. Phillips, S. Mallal,
... developed a rapid flow cytometry method for HLA-B57 phenotyping using commercially available B17 monoclonal antibodies. Methods ... the CD45+ lymphocyte population. Results All eight HLA-B57 individuals examined tested positive, while HLA-B57/58 negative individuals (n=74) tested negative for this flow cytometry test. Two non-HLA-B57 individuals showed weak cross-reactivity. Conclusion In our ...
Tópico(s): Pharmacovigilance and Adverse Drug Reactions
2006 - Lippincott Williams & Wilkins | Pharmacogenetics and Genomics