Paul W. Douglas, Max Beloff, John Slessor, Douglas Sisson, Rodney F. Hall,
... Money, Please British Standards Institution Forecasting Workers Labour BHT Spells Out Food Regulations Shorter Note Luncheon Vouchers ...
1963 - Gale Group | The Economist
I.F. Gaunt, G. Feuer, F.A. Fairweather, D.A. Gilbert,
... daily doses (500 mg/kg) of butylated hydroxytoluene (BHT; 3,5-di-tert-butyl-4-hydroxytoluene) or ... 3-tert-butyl-4-hydroxyanisole). Both BHA and BHT induced liver enlargement and increased daily output of ... and slower in onset yet more prolonged with BHT. Administration of BHA or BHT at a level of 0·1% in the ... wk elicited similar changes, particularly in females. With BHT the effects were more pronounced and more prolonged, ... phosphatase and glucose 6-phosphate dehydrogenase activities. Both BHT and BHA brought about increases in adrenal weight. ...
Tópico(s): Vitamin K Research Studies
1965 - Elsevier BV | Food and Cosmetics Toxicology
John P. Frawley, JK Kay, J.C. Calandra,
Radioactive butylated hydroxytoluene (BHT; 3,5-di-tert-butyl-4-hydroxytoluene), ring-labelled with 14C, has been fed to one-day-old chickens ... wk and all tissues and organs analyzed for BHT and metabolites. Maximum residue levels were found after ... edible portions contained between 1 and 3 ppm BHT and metabolites. Slightly higher concentrations were found in ... the light of all the toxicological data on BHT, these results confirm the safety of the use of BHT up to 200 ppm in chicken feed. Du butylate d'hydroxytoluène radio-actif (BHT; 3,5-di-tert-butyl-4-hydroxytoluène), marqué ...
Tópico(s): Agricultural safety and regulations
1965 - Elsevier BV | Food and Cosmetics Toxicology
In female rats given butylated hydroxytoluene (BHT; 3,5-di-tert-butyl-4-hydroxytoluene) by stomach tube (500 mg/kg daily for 84 days) liver enlargement was associated with ... time course and dose-response relationship of the BHT effect revealed a close correlation between increased relative ... enhanced processing enzyme activity and mobilization of stored BHT from abdominal fat. In rats of both sexes given BHT as above for up to 21 days, RLW ... raised by the second day, by which time BHT content of fat had attained values of 230 ...
Tópico(s): Diet and metabolism studies
1965 - Elsevier BV | Food and Cosmetics Toxicology
John P. Frawley, Friederike Köhn, JK Kay, J.C. Calandra,
... 0, 300, 1000 or 3000 ppm butylated hydroxytoluene (BHT; 3,5-di-tert-butyl-4-hydroxytoluene). At ... study. At the 3000 ppm dietary level of BHT, a 10–20% reduction in growth rate of ... a "no-effect" level of 1000 ppm of BHT in a high fat diet is established. Des ... 1000 et 3000 ppm de butylate d'hydroxytoluène (BHT; 3,5-di-tert-butyl-4-hydroxytoluène). A ... en cours d'étude. Pour un taux de BHT de 3000 ppm dans le régime alimentaire, on ... prouver qu'un taux de 1000 ppm de BHT dans un régime alimentaire riche en lipides n' ...
Tópico(s): Metabolism and Genetic Disorders
1965 - Elsevier BV | Food and Cosmetics Toxicology
J.W. Daniel, J. C. Gage, Daniel Jones, Marianne Stevens,
... a single oral dose of [14C]butylated hydroxytoluene (BHT) to man, about 75% of the administered radioactivity ... of excretion is similar for both BHA and BHT. There is an early rapid excretion in which ... the relative rates of excretion of BHA and BHT by man and by the rat can probably ... attributed to a difference between the metabolism of BHT in the two species. Après l'administration à ... homme d'une dose unique d'hydroxytoluène butylé (BHT) marqué au carbone-14, 75% environ de la ... excrétion est similaire pour le BHA et le BHT. Au début il y a excrétion rapide, au ...
Tópico(s): Effects and risks of endocrine disrupting chemicals
1967 - Elsevier BV | Food and Cosmetics Toxicology
Paul E. Wanda, James Cupp, Wallace Snipes, Alec D. Keith, Tom Rucinsky, Louis B. Polish, Jeffrey A. Sands,
Butylated hydroxytoluene (BHT) is a potent inactivator of the enveloped bacterial virus ø6 at concentrations as low as 3 × 10 −5 M. The viral envelope is not removed by BHT treatment, in contrast to the effects of exposure to the detergent Triton X-100. BHT-treated viruses are morphologically indistinguishable from controls but ... be a crucial factor in the effectiveness of BHT against ø6. A precipitous drop in the degree of inactivation by 3 × 10 −5 M BHT occurred when the temperature was lowered from 20 ...
Tópico(s): Respiratory viral infections research
1976 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
James P. Kehrer, Hanspeter Witschi,
The administration of butylated hydroxytoluene (BHT) to mice results in lung cell damage followed by cellular proliferation which was quantitated by measuring the increase in thymidine incorporation ... A or piperonyl butoxide to mice treated with BHT prevented the increase in thymidine incorporation into pulmonary ... dependent, with complete protection from 400 mg/kg BHT achieved with 10 mg/kg SKF 525-A ... 525-A and piperonyl butoxide completely prevented the BHT-induced increase in pulmonary DNA synthesis even when ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
1980 - Elsevier BV | Toxicology and Applied Pharmacology
Borge M. Ulland, J. H. Weisburger, R. Yamamoto, Elizabeth K. Weisburger,
The effect of butylated hydroxytoluene (BHT) and diphenyl-p-phenylenediamine (DPPD) on cancer induction by N-2-fluorenylacetamide (FAA) and its N-hydroxy derivative (N-OH-FAA) ... mM) and 7850 ppm DPPD or 6600 ppm BHT) in Wayne Chow for 24 wk (males) or ... these agents in male or female rats. However, BHT reduced the incidence of hepatoma in males to ... the carcinogen was FAA. With N-OH-FAA, BHT lowered the incidence of liver tumours to 15% ... females to 35%. Similar data on inhibition by BHT were obtained using different levels of carcinogens in ...
Tópico(s): Glutathione Transferases and Polymorphisms
1973 - Elsevier BV | Food and Cosmetics Toxicology
A.L. Branen, T. Richardson, M. C. Goel, J. R. Allen,
When butylated hydroxytoluene (BHT) or butylated hydroxyanisole (BHA) was given to young monkeys in daily doses of 50 or 500 mg/kg/body ... significantly lowered by treatment with either BHA or BHT in doses of 500 mg/kg/ day, although ... was more effective. Treatment with either BHA or BHT at 50 mg/kg/day significantly lowered liver cholesterol, but only BHT significantly lowered plasma cholesterol at this dosage level. ... were significantly increased by 500 mg BHA or BHT/kg/day and all animals receiving this dose ...
Tópico(s): Metabolism and Genetic Disorders
1973 - Elsevier BV | Food and Cosmetics Toxicology
Preston H. Grantham, J. H. Weisburger, Elizabeth K. Weisburger,
The effect of the antioxidant butylated hydroxytoluene (BHT) on the metabolism of N-2-fluorenylacetamide (FAA) and N-hydroxy-N-2-fluorenylacetamide (N-OH-FAA) was studied in male and female rats. The administration of 6600 ppm BHT in the diet for 4 wk increased the ... of the labelled carcinogen. It is concluded that BHT increases the detoxification metabolites of FAA and N- ... l'effet d'un oxydant, l'hydroxytoluène butylé (BHT), sur le métabolisme du N-2-fluorénylacétamide (FAA) ... hydroxy-N-2-fluorénylacétamide (N-OH-FAA). Le BHT administré pendant 4 semaines à raison de 6600 ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1973 - Elsevier BV | Food and Cosmetics Toxicology
Hiroshi INUI, Satoshi Akutsu, Kazuko Itoh, Masatoshi Matsuo, Junshi MIYAMOTO,
... 3,5-di-tert-butyl-4-hydroxy-toluene (BHT) and its degradation product 3,5-di-tert-butyl-4-hydroxy-benzaldehyde (BHT-CHO) are presented. BHT and BHT-CHO were detected in all samples of the ... of 178 and 102 ng l−1, respectively. BHT and BHT-CHO were also detected in effluent waste water ... rain water sample, 308 ng l−1 of BHT and 155 ng l−1 of BHT-CHO were measured. Both compounds were detected in ...
Tópico(s): Environmental Chemistry and Analysis
1979 - Elsevier BV | Chemosphere
... ip injection of 400 mg/kg butylated hydroxytoluene (BHT) with a loss of body weight and a ... however, if (a) other antioxidants, substituted phenols or BHT metabolites were used rather than BHT itself; (b) mice were under 3 weeks of ... sesquiterpenoid compounds derived from cedarwood. This prevention of BHT-induced lung damage by the cedar terpenes could not be overcome either by increasing the BHT dose up to 2500 mg/kg, or by ... hr after the mice had been injected with BHT. The resistance conferred by the terpenes was fully ...
Tópico(s): Ginger and Zingiberaceae research
1979 - Elsevier BV | Toxicology and Applied Pharmacology
Neal K. Clapp, N. D. Bowles, L. C. Satterfield, W C Klima,
The effect of the antioxidant butylated hydroxytoluene (BHT) was determined in 1,2-dimethylhydrazine (DMH) colon carcinogenesis. The following groups were comprised of female and male BALB/c mice that were either 1) given BHT (0.75% in the feed) for life beginning ... at 11 weeks of age, 3) treated with BHT plus DMH, or 4) maintained as untreated controls. Mice of both sexes treated with BHT plus DMH had increased survival over those given ... tumor incidences were reduced in male mice given BHT plus DMH compared with the incidence in males ...
Tópico(s): Bioactive Compounds and Antitumor Agents
1979 - Oxford University Press | JNCI Journal of the National Cancer Institute
Treatment of mice intraperitoneally with butylated hydroxytoluene (BHT) results in the formation of a diffuse, dose-dependent lung lesion. At high doses of BHT, pulmonary flbrosis becomes evident. The rate of collagen production was measured in vitro in normal and BHT-damaged lung tissue by quantitating the formation of ... incubation. Collagen production was elevated 2 days after BHT (400 mg/kg) and reached a maximum rate ... synthesis was committed to collagen 7 days after BHT. Control mice committed 0.6% to collagen synthesis. ...
Tópico(s): Delphi Technique in Research
1982 - Elsevier BV | Biochemical Pharmacology
Peter C. Rubin, Colin W. Howden, Kathleen McLean, John L. Reid,
... in man with a specific α2-adrenoceptor agonist BHT-933. The study involved nine male normotensive volunteers each of whom received BHT-933 5 mg or placebo in random order. BHT-933 significantly lowered systolic and diastolic blood pressure ( ... following drug administration. Supine values: placebo 116/73; BHT-933 99/64. Standing values: placebo 114/79: BHT-933 92/67. Heart rate was uninfluenced by BHT-933 even at the time of maximum fall ... reduced: placebo 2.5 ± 0.8 nmol/L: BHT-933 1.7 ± 0.6. The haemodynamic changes ...
Tópico(s): Blood Pressure and Hypertension Studies
1982 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology
Kazuo Tajima, Kenji Yamamoto, Tamio Mizutani,
... butyl-4-methylene-2, 5-cyclohexadien-1-one (BHT-quinone methide, BHT-QM) was detected in the bile of rats given butylated hydroxytoluene (BHT). The biliary excretion of BHT-QM during 24 h after administration of BHT, 3, 5-di-tert-butyl-4-hydroxybenzyl alcohol (BHT-alcohol), or 2, 6-di-tert-butyl-4- ... methyl-2, 5-cyclohexadien-1-one (4-hydroxy-BHT) was determined by high-performance liquid chromatography. BHT-alcohol gave about 7 times as much BHT- ...
Tópico(s): Synthesis of Indole Derivatives
1981 - Pharmaceutical Society of Japan | Chemical and Pharmaceutical Bulletin
... formation in lung; phorbol, saccharin and butylated hydroxytoluene (BHT). The antioxidant BHT acts in many respects like a typical promoting ... not if they are treated beforehand. Administration of BHT can be delayed up to 5 months after urethan treatment and still enhance tumor formation. BHT enhances lung tumor formation regardless of its route ... ingestion in the diet). The lowest dose of BHT required to produce an effect has not yet been determined. In at least one mouse strain, BHT also enhances tumor formation in animals initiated with ...
Tópico(s): Biopolymer Synthesis and Applications
1983 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
... Although the average American's daily consumption of BHT can be measured in milligrams, there are numerous reports that BHT causes organ damage in laboratory animals. Only a few genotoxic effects of BHT have been reported, however, including mutagenicity in the ... teratogenicity. More dramatic are the modulatory effects of BHT on the actions of established mutagens and carcinogens. BHT can either enhance or inhibit mutagenic potency, depending ... substance tested. For example, in the Ames test, BHT is antimutagenic towards benzo(a)pyrene, but increases ...
Tópico(s): Radiation Effects and Dosimetry
1983 - Wiley | Environmental Mutagenesis
Tamio Mizutani, Kenji Yamamoto, Kazuo Tajima,
... hydroxytoluene (2,6-di-tert.-butyl-4-methylphenol, BHT) and 2,6-di-tert.-butyl-4-[alpha, alpha, alpha-2H3]methylphenol (BHT-d3) showed a significantly lower toxic potency of the latter. The rate of in vitro BHT metabolism to 2,6-di-tert.-butyl-4-methylene-2,5-cyclohexadienone (BHT-QM) was slowed by deuterating BHT in the 4-methyl group. On the other ... butyl-4-hydroxy-4-methyl-2,5-cyclohexadienone (BHT-OH) was increased with the deuteration. A similar ... substitution on the in vivo metabolic rates of BHT was observed. These observations support the concept that ...
Tópico(s): Chemical Reactions and Isotopes
1983 - Elsevier BV | Toxicology and Applied Pharmacology
The metabolism of butylated hydroxytoluene (BHT) and the effect of BHT on the metabolism of diethylnitrosamine (DEN) was studied in male and female BALB/c mice to further understanding of the selective protection of BHT on the incidence of DEN-induced squamous-stomach ... in male) mice. Following intragastric administration of [14C]BHT, the antioxidant was covalently bound to tissue macromolecules. The relative distribution of this bound BHT varied with time; 8 hr after [14C]BHT administration, most of the covalently bound BHT was ...
Tópico(s): Sulfur Compounds in Biology
1984 - Elsevier BV | Food and Chemical Toxicology
L. A. Cohen, M. Polansky, K. Furuya, M. Reddy, B. Berke, J. H. Weisburger,
Dietary butylated hydroxytoluene (BHT) fed 14 days before and 14 days after carcinogen administration resulted in a dose-dependent inhibition of 7,12- ... Dawley rats. In addition, the inhibitory effects of BHT were strongly influenced by the dose of initiating carcinogen and the type of diet in which BHT was administered. In animals fed the NIH-07 ... DMBA (5 mg/rat), the inhibitory effect of BHT was manifested at all four BHT concentrations (6,000→300 ppm). Maximal inhibition was ... 5 mg DMBA and receiving 6,000 ppm BHT. However, in the group administered a high dose ...
Tópico(s): Metastasis and carcinoma case studies
1984 - Oxford University Press | JNCI Journal of the National Cancer Institute
A M Malkinson, Deborah S. Beer,
Food additive butylated hydroxytoluene (BHT) (CAS: 128-37-0; 2,6-di-tert-butyl-p-cresol) can modulate the formation of lung adenomas in mice ... ethyl ester carbamic acid). An ip injection of BHT administered 6 hours before a single urethan injection ... the number of tumors formed, whereas six weekly BHT injections following a single urethan dose increased tumor multiplicity. Biotransformation of BHT was apparently required for both prophylaxis and enhancement. ... which perturbs drug metabolism, prevented both of these BHT activities. Analogues of BHT with different substitutions at ...
Tópico(s): Carcinogens and Genotoxicity Assessment
1984 - Oxford University Press | JNCI Journal of the National Cancer Institute
James P. Kehrer, Andres J. Klein–Szanto, Elsie M. B. Sorensen, Rodney Pearlman, Mitchell H. Rosner,
The administration of butylated hydroxytoluene (BHT) to mice has been shown to produce diffuse alveolar epithelial cell damage, which is largely resolved within 2 wk. Treatment with ... twice daily during the first 5 days after BHT, greatly exacerbated the initial damage. A severe interstitial pneumonitis was evident histologically 15 days after BHT-treatment. The infiltrate became even more extensive 22 days after BHT with a massive consolidation of the lungs. The ... pneumonitis was virtually gone at 60 days after BHT-treatment. The extent of the fibrotic changes, as ...
Tópico(s): Inhalation and Respiratory Drug Delivery
1984 - American Thoracic Society | American Review of Respiratory Disease
Christine Förster, Paul W. Armstrong,
... as compared with control. The maximum responses to BHT 920 and BHT 933 remained unaltered after CHF, but both vessels showed decreased sensitivity to BHT 920. Before CHF, the rank order of potency ... greater than epinephrine greater than methoxamine greater than BHT 933 greater than BHT 920, and for the saphenous vein was epinephrine greater than NE greater than BHT 933 greater than methoxamine greater than BHT 920. At peak CHF, the rank order of ... greater than NE greater than methoxamine greater than BHT 933 greater than BHT 920, whereas in the ...
Tópico(s): Cardiovascular Conditions and Treatments
1990 - Lippincott Williams & Wilkins | Journal of Cardiovascular Pharmacology